JP2011529070A5 - - Google Patents
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- JP2011529070A5 JP2011529070A5 JP2011520187A JP2011520187A JP2011529070A5 JP 2011529070 A5 JP2011529070 A5 JP 2011529070A5 JP 2011520187 A JP2011520187 A JP 2011520187A JP 2011520187 A JP2011520187 A JP 2011520187A JP 2011529070 A5 JP2011529070 A5 JP 2011529070A5
- Authority
- JP
- Japan
- Prior art keywords
- methyl
- oxy
- carbonyl
- amino
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US8362108P | 2008-07-25 | 2008-07-25 | |
| US61/083,621 | 2008-07-25 | ||
| PCT/US2009/051499 WO2010011814A1 (en) | 2008-07-25 | 2009-07-23 | Chemical compounds |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014106310A Division JP5738457B2 (ja) | 2008-07-25 | 2014-05-22 | 化合物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011529070A JP2011529070A (ja) | 2011-12-01 |
| JP2011529070A5 true JP2011529070A5 (OSRAM) | 2012-09-06 |
| JP5586602B2 JP5586602B2 (ja) | 2014-09-10 |
Family
ID=41570595
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011520187A Active JP5586602B2 (ja) | 2008-07-25 | 2009-07-23 | 化合物 |
| JP2014106310A Active JP5738457B2 (ja) | 2008-07-25 | 2014-05-22 | 化合物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014106310A Active JP5738457B2 (ja) | 2008-07-25 | 2014-05-22 | 化合物 |
Country Status (9)
| Country | Link |
|---|---|
| US (7) | US8580967B2 (OSRAM) |
| EP (2) | EP2320909B8 (OSRAM) |
| JP (2) | JP5586602B2 (OSRAM) |
| KR (3) | KR101700267B1 (OSRAM) |
| CN (3) | CN103951643B (OSRAM) |
| ES (2) | ES2607403T3 (OSRAM) |
| PT (1) | PT2660239T (OSRAM) |
| SG (1) | SG192550A1 (OSRAM) |
| WO (1) | WO2010011814A1 (OSRAM) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103951643B (zh) | 2008-07-25 | 2015-12-09 | 盐野义制药株式会社 | 用作hiv整合酶抑制剂的化合物 |
| KR101733625B1 (ko) | 2008-12-11 | 2017-05-10 | 시오노기세야쿠 가부시키가이샤 | 카르바모일피리돈 hiv 인테그라제 억제제 및 중간체의 합성 |
| KR101663222B1 (ko) * | 2008-12-11 | 2016-10-06 | 시오노기세야쿠 가부시키가이샤 | 말톨 에테르 방법 및 중간체 |
| KR101678563B1 (ko) | 2008-12-11 | 2016-11-22 | 비이브 헬쓰케어 컴퍼니 | 카르바모일피리돈 hiv 인테그라제 억제제를 위한 제조방법 및 중간체 |
| TWI518084B (zh) | 2009-03-26 | 2016-01-21 | 鹽野義製藥股份有限公司 | 哌喃酮與吡啶酮衍生物之製造方法 |
| TWI582097B (zh) | 2010-03-23 | 2017-05-11 | Viiv醫療保健公司 | 製備胺甲醯吡啶酮衍生物及中間體之方法 |
| TWI577377B (zh) * | 2010-09-16 | 2017-04-11 | Viiv醫療保健公司 | 醫藥組合物 |
| CA2812363C (en) | 2010-09-24 | 2019-04-02 | Shionogi & Co., Ltd. | Substituted polycyclic carbamoyl pyridone derivative prodrug |
| CA2893843C (en) | 2012-12-21 | 2018-09-04 | Gilead Sciences, Inc. | Polycyclic-carbamoylpyridone compounds and their pharmaceutical use |
| NO2865735T3 (OSRAM) | 2013-07-12 | 2018-07-21 | ||
| DK3019503T3 (da) | 2013-07-12 | 2017-11-20 | Gilead Sciences Inc | Polycykliske-carbamoylpyridon-forbindelser og anvendelse deraf til behandling af hiv-infektioner |
| WO2015108945A2 (en) | 2014-01-14 | 2015-07-23 | Board Of Regents Of The University Of Nebraska | Compositions and methods for the delivery of therapeutics |
| TWI677489B (zh) | 2014-06-20 | 2019-11-21 | 美商基利科學股份有限公司 | 多環型胺甲醯基吡啶酮化合物之合成 |
| TW201613936A (en) | 2014-06-20 | 2016-04-16 | Gilead Sciences Inc | Crystalline forms of(2R,5S,13aR)-8-hydroxy-7,9-dioxo-n-(2,4,6-trifluorobenzyl)-2,3,4,5,7,9,13,13a-octahydro-2,5-methanopyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazepine-10-carboxamide |
| NO2717902T3 (OSRAM) | 2014-06-20 | 2018-06-23 | ||
| US11311545B2 (en) | 2014-10-09 | 2022-04-26 | Board Of Regents Of The University Of Nebraska | Compositions and methods for the delivery of therapeutics |
| TWI738321B (zh) | 2014-12-23 | 2021-09-01 | 美商基利科學股份有限公司 | 多環胺甲醯基吡啶酮化合物及其醫藥用途 |
| TR201905009T4 (tr) | 2015-04-02 | 2019-05-21 | Gilead Sciences Inc | Polisiklik-karbamoilpiridon bileşikleri ve bunların farmasötik kullanımları. |
| ES3035041T3 (en) * | 2016-06-23 | 2025-08-27 | Viiv Healthcare Co | Compositions and methods for the delivery of therapeutics |
| WO2019016679A1 (en) * | 2017-07-18 | 2019-01-24 | Viiv Healthcare Company | Combination drug therapy |
| AU2018344739B2 (en) | 2017-10-06 | 2023-04-13 | Shionogi & Co., Ltd. | Stereoselective process for preparing substituted polycyclic pyridone derivatives |
| TWI795462B (zh) * | 2017-11-17 | 2023-03-11 | 日商鹽野義製藥股份有限公司 | 光安定性及溶出性優異的醫藥製劑 |
| US11839623B2 (en) | 2018-01-12 | 2023-12-12 | Board Of Regents Of The University Of Nebraska | Antiviral prodrugs and formulations thereof |
| US11458136B2 (en) | 2018-04-09 | 2022-10-04 | Board Of Regents Of The University Of Nebraska | Antiviral prodrugs and formulations thereof |
| EP4234560A3 (en) | 2018-10-22 | 2023-09-13 | Board of Regents of the University of Nebraska | Antiviral prodrugs and nanoformulations thereof |
| CN113382737B (zh) | 2018-11-29 | 2025-06-03 | 内布拉斯加大学董事会 | 抗病毒前药及其纳米制剂 |
| IL286328B1 (en) | 2019-03-22 | 2026-04-01 | Gilead Sciences Inc | Tricyclic bridging compounds of carbamoylpyridone and their pharmaceutical use |
| WO2020221294A1 (zh) * | 2019-04-30 | 2020-11-05 | 上海拓界生物医药科技有限公司 | 桥环-3,4-二氢-吡啶并[1,2-a]吡嗪-1,8-二酮化合物及其药物用途 |
| WO2021129602A1 (zh) * | 2019-12-23 | 2021-07-01 | 石家庄迪斯凯威医药科技有限公司 | 取代的多环化合物及其药物组合物和用途 |
| CR20220418A (es) | 2020-02-24 | 2022-10-10 | Gilead Sciences Inc | Compuestos tetracíclicos para el tratamiento de infecciones por vih |
| CA3192145A1 (en) | 2020-09-30 | 2022-04-07 | Gilead Sciences, Inc. | Bridged tricyclic carbamoylpyridone compounds and uses thereof |
| CN114426540B (zh) * | 2020-10-29 | 2024-04-26 | 上海拓界生物医药科技有限公司 | 吡啶并[1,2-a]吡嗪-1,8-二酮类前药衍生物、其制备方法及其应用 |
| JP7591155B2 (ja) | 2021-01-19 | 2024-11-27 | ギリアード サイエンシーズ, インコーポレイテッド | 置換ピリドトリアジン化合物及びその使用 |
| WO2022177840A1 (en) * | 2021-02-16 | 2022-08-25 | Merck Sharp & Dohme Llc | Tetracyclic heterocycle compounds useful as hiv integrase inhibitors |
| TWI856796B (zh) | 2022-04-06 | 2024-09-21 | 美商基利科學股份有限公司 | 橋聯三環胺甲醯基吡啶酮化合物及其用途 |
| CN120424092B (zh) * | 2025-07-02 | 2025-09-12 | 中国人民解放军军事科学院军事医学研究院 | 布尼亚病毒抑制剂及其制备方法和用途 |
Family Cites Families (57)
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| US1544199A (en) * | 1922-08-21 | 1925-06-30 | Herman Christensen | Condenser |
| GB427857A (en) | 1934-08-02 | 1935-05-01 | Newsum Sons & Company Ltd H | A new or improved system of construction for skeleton structures, particularly vehicle body frames and door frames |
| US4524149A (en) * | 1982-03-15 | 1985-06-18 | Sterling Drug Inc. | 5-Alkanoyl-6-alkyl-2(1H)-pyridinones, their preparation and their cardiotonic use |
| US4769380A (en) * | 1983-04-29 | 1988-09-06 | Merrell Dow Pharmaceuticals Inc. | Cardiotonic 5-benzoyl-1,2-dihydro-2-oxo-3-pyridinecarboxylates |
| US4735964A (en) * | 1984-08-16 | 1988-04-05 | G. D. Searle & Co. | Kojic acid ether-ester derivatives |
| US4603144A (en) | 1984-08-16 | 1986-07-29 | G. D. Searle & Co. | Kojic acid ether-ester derivatives |
| US4812474A (en) * | 1984-08-16 | 1989-03-14 | G. D. Searle & Co. | Kojic acid ether-ester derivatives |
| CA1317298C (en) * | 1987-03-03 | 1993-05-04 | Upjohn Company (The) | Antibiotic sulfonylaminocarbonyl activated .beta.-lactams |
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| ES2244967T3 (es) | 1995-09-29 | 2005-12-16 | Novartis Ag | Nuevas hidroxipiridinonas. |
| GB9711093D0 (en) | 1997-05-29 | 1997-07-23 | British Tech Group | Novel orally active iron (III) chelators |
| US6452008B2 (en) * | 1998-02-25 | 2002-09-17 | Sumitomo Pharmaceuticals Company, Limited | Pyridone derivatives and process for preparing the same |
| US7256286B2 (en) * | 1999-11-30 | 2007-08-14 | The Board Of Trustees Of The Leland Stanford Junior University | Bryostatin analogues, synthetic methods and uses |
| KR20040030893A (ko) * | 2001-08-02 | 2004-04-09 | 뉴로크린 바이오사이언시즈 인코퍼레이티드 | 치환된 피리딘-4-온 및 고나도트로핀 분비 호르몬 수용체길항제로서의 이의 용도 |
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| US20060066414A1 (en) * | 2004-09-28 | 2006-03-30 | Rockwell Scientific Licensing, Llc | Method and apparatus for changing the polarization of a signal |
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| US20060246196A1 (en) | 2005-04-27 | 2006-11-02 | Lawson John A | Low-alcohol, low-calorie wine |
| PT1874117E (pt) | 2005-04-28 | 2013-10-17 | Shionogi & Co | Derivado policíclico de carbamoílpiridona possuindo actividade inibidora de hiv-integrasse |
| CN101212903B (zh) * | 2005-04-28 | 2013-07-24 | 史密丝克莱恩比彻姆公司 | 具有hiv整合酶抑制活性的多环氨基甲酰基吡啶酮衍生物 |
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| AU2006307101A1 (en) * | 2005-10-27 | 2007-05-03 | Shionogi & Co., Ltd. | Polycyclic carbamoylpyridone derivative having inhibitory activity on HIV integrase |
| GB0623768D0 (en) * | 2006-11-28 | 2007-01-10 | Chopra Sunil | A bleomycin preparation for use against skin tumours |
| JP2010512355A (ja) * | 2006-12-11 | 2010-04-22 | トポターゲット・アクティーゼルスカブ | 癌の処置のためのジフェニルオキシ−インドール−2−オン化合物のプロドラッグ |
| JP5074042B2 (ja) * | 2007-01-10 | 2012-11-14 | Hoya株式会社 | 情報記録媒体基板用素材、情報記録媒体基板、情報記録媒体それぞれの製造方法 |
| US8314087B2 (en) | 2007-02-16 | 2012-11-20 | Amgen Inc. | Nitrogen-containing heterocyclyl ketones and methods of use |
| JP5551697B2 (ja) * | 2008-07-25 | 2014-07-16 | ビーブ・ヘルスケア・カンパニー | 化合物 |
| SI2320908T1 (sl) * | 2008-07-25 | 2014-05-30 | Viiv Healthcare Company | Predzdravila dolutegravirja |
| CN103951643B (zh) | 2008-07-25 | 2015-12-09 | 盐野义制药株式会社 | 用作hiv整合酶抑制剂的化合物 |
| US8309008B2 (en) * | 2008-10-30 | 2012-11-13 | Molecular Imprints, Inc. | Separation in an imprint lithography process |
| KR101733625B1 (ko) * | 2008-12-11 | 2017-05-10 | 시오노기세야쿠 가부시키가이샤 | 카르바모일피리돈 hiv 인테그라제 억제제 및 중간체의 합성 |
| KR101678563B1 (ko) | 2008-12-11 | 2016-11-22 | 비이브 헬쓰케어 컴퍼니 | 카르바모일피리돈 hiv 인테그라제 억제제를 위한 제조방법 및 중간체 |
| TWI518084B (zh) | 2009-03-26 | 2016-01-21 | 鹽野義製藥股份有限公司 | 哌喃酮與吡啶酮衍生物之製造方法 |
| TWI582097B (zh) | 2010-03-23 | 2017-05-11 | Viiv醫療保健公司 | 製備胺甲醯吡啶酮衍生物及中間體之方法 |
| PT2602260T (pt) | 2010-08-05 | 2016-12-27 | Shionogi & Co | Processo para preparar composto possuindo atividade inibidora de integrase do vih |
-
2009
- 2009-07-23 CN CN201310734307.XA patent/CN103951643B/zh active Active
- 2009-07-23 ES ES13178055.3T patent/ES2607403T3/es active Active
- 2009-07-23 JP JP2011520187A patent/JP5586602B2/ja active Active
- 2009-07-23 ES ES09800991.3T patent/ES2562452T3/es active Active
- 2009-07-23 EP EP09800991.3A patent/EP2320909B8/en active Active
- 2009-07-23 KR KR1020167033294A patent/KR101700267B1/ko active Active
- 2009-07-23 KR KR1020117004493A patent/KR101695807B1/ko active Active
- 2009-07-23 CN CN200980135216.6A patent/CN102149385B/zh active Active
- 2009-07-23 CN CN201510553892.2A patent/CN105198804B/zh active Active
- 2009-07-23 PT PT131780553T patent/PT2660239T/pt unknown
- 2009-07-23 US US13/054,847 patent/US8580967B2/en active Active
- 2009-07-23 WO PCT/US2009/051499 patent/WO2010011814A1/en not_active Ceased
- 2009-07-23 KR KR1020167033296A patent/KR101772610B1/ko active Active
- 2009-07-23 EP EP13178055.3A patent/EP2660239B1/en active Active
- 2009-07-23 SG SG2013056528A patent/SG192550A1/en unknown
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2013
- 2013-10-02 US US14/044,285 patent/US8765965B2/en active Active
- 2013-10-02 US US14/044,258 patent/US8940912B2/en active Active
-
2014
- 2014-05-20 US US14/282,049 patent/US8981129B2/en active Active
- 2014-05-21 US US14/283,465 patent/US9012650B2/en active Active
- 2014-05-22 JP JP2014106310A patent/JP5738457B2/ja active Active
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2015
- 2015-03-17 US US14/660,063 patent/US9133216B2/en active Active
- 2015-08-05 US US14/818,539 patent/US9707246B2/en active Active
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