|
US4275149A
(en)
|
1978-11-24 |
1981-06-23 |
Syva Company |
Macromolecular environment control in specific receptor assays
|
|
US4318980A
(en)
|
1978-04-10 |
1982-03-09 |
Miles Laboratories, Inc. |
Heterogenous specific binding assay employing a cycling reactant as label
|
|
US4376110A
(en)
|
1980-08-04 |
1983-03-08 |
Hybritech, Incorporated |
Immunometric assays using monoclonal antibodies
|
|
US4489710A
(en)
|
1981-06-23 |
1984-12-25 |
Xoma Corporation |
Composition and method for transplantation therapy
|
|
US4429008B1
(en)
|
1981-12-10 |
1995-05-16 |
Univ California |
Thiol reactive liposomes
|
|
US4671958A
(en)
|
1982-03-09 |
1987-06-09 |
Cytogen Corporation |
Antibody conjugates for the delivery of compounds to target sites
|
|
JPS59116229A
(ja)
|
1982-12-24 |
1984-07-05 |
Teijin Ltd |
細胞毒性複合体を活性成分とする癌治療用剤およびその製造法
|
|
US4486414A
(en)
|
1983-03-21 |
1984-12-04 |
Arizona Board Of Reagents |
Dolastatins A and B cell growth inhibitory substances
|
|
GB8308235D0
(en)
|
1983-03-25 |
1983-05-05 |
Celltech Ltd |
Polypeptides
|
|
US4816567A
(en)
|
1983-04-08 |
1989-03-28 |
Genentech, Inc. |
Recombinant immunoglobin preparations
|
|
US4673562A
(en)
|
1983-08-19 |
1987-06-16 |
The Children's Medical Center Corporation |
Bisamide bisthiol compounds useful for making technetium radiodiagnostic renal agents
|
|
US4873088A
(en)
|
1983-09-06 |
1989-10-10 |
Liposome Technology, Inc. |
Liposome drug delivery method and composition
|
|
US4625014A
(en)
|
1984-07-10 |
1986-11-25 |
Dana-Farber Cancer Institute, Inc. |
Cell-delivery agent
|
|
US4542225A
(en)
|
1984-08-29 |
1985-09-17 |
Dana-Farber Cancer Institute, Inc. |
Acid-cleavable compound
|
|
US4638045A
(en)
|
1985-02-19 |
1987-01-20 |
Massachusetts Institute Of Technology |
Non-peptide polyamino acid bioerodible polymers
|
|
US4683202A
(en)
|
1985-03-28 |
1987-07-28 |
Cetus Corporation |
Process for amplifying nucleic acid sequences
|
|
US4683195A
(en)
|
1986-01-30 |
1987-07-28 |
Cetus Corporation |
Process for amplifying, detecting, and/or-cloning nucleic acid sequences
|
|
US4737456A
(en)
|
1985-05-09 |
1988-04-12 |
Syntex (U.S.A.) Inc. |
Reducing interference in ligand-receptor binding assays
|
|
US4699784A
(en)
|
1986-02-25 |
1987-10-13 |
Center For Molecular Medicine & Immunology |
Tumoricidal methotrexate-antibody conjugate
|
|
US5225539A
(en)
|
1986-03-27 |
1993-07-06 |
Medical Research Council |
Recombinant altered antibodies and methods of making altered antibodies
|
|
US5260203A
(en)
|
1986-09-02 |
1993-11-09 |
Enzon, Inc. |
Single polypeptide chain binding molecules
|
|
US4735792A
(en)
|
1987-04-28 |
1988-04-05 |
The United States Of America As Represented By The United States Department Of Energy |
Radioiodinated maleimides and use as agents for radiolabeling antibodies
|
|
US4816444A
(en)
|
1987-07-10 |
1989-03-28 |
Arizona Board Of Regents, Arizona State University |
Cell growth inhibitory substance
|
|
IL87172A
(en)
|
1987-07-23 |
1994-12-29 |
Univ Washington |
Method of isolating highly purified tissue factor inhibitor
|
|
US5080891A
(en)
|
1987-08-03 |
1992-01-14 |
Ddi Pharmaceuticals, Inc. |
Conjugates of superoxide dismutase coupled to high molecular weight polyalkylene glycols
|
|
US4981785A
(en)
|
1988-06-06 |
1991-01-01 |
Ventrex Laboratories, Inc. |
Apparatus and method for performing immunoassays
|
|
EP0440663A1
(de)
|
1988-08-08 |
1991-08-14 |
IFFIU, Michael A. |
Klappbares sesselrad mit stromlinienförmiger, in drei geteilter und faltbarer verkleidung
|
|
US5223409A
(en)
|
1988-09-02 |
1993-06-29 |
Protein Engineering Corp. |
Directed evolution of novel binding proteins
|
|
EP0436597B1
(en)
|
1988-09-02 |
1997-04-02 |
Protein Engineering Corporation |
Generation and selection of recombinant varied binding proteins
|
|
US5076973A
(en)
|
1988-10-24 |
1991-12-31 |
Arizona Board Of Regents |
Synthesis of dolastatin 3
|
|
EP0368684B2
(en)
|
1988-11-11 |
2004-09-29 |
Medical Research Council |
Cloning immunoglobulin variable domain sequences.
|
|
US5530101A
(en)
|
1988-12-28 |
1996-06-25 |
Protein Design Labs, Inc. |
Humanized immunoglobulins
|
|
US4978744A
(en)
|
1989-01-27 |
1990-12-18 |
Arizona Board Of Regents |
Synthesis of dolastatin 10
|
|
US4879278A
(en)
|
1989-05-16 |
1989-11-07 |
Arizona Board Of Regents |
Isolation and structural elucidation of the cytostatic linear depsipeptide dolastatin 15
|
|
US6291158B1
(en)
|
1989-05-16 |
2001-09-18 |
Scripps Research Institute |
Method for tapping the immunological repertoire
|
|
CA2016841C
(en)
|
1989-05-16 |
1999-09-21 |
William D. Huse |
A method for producing polymers having a preselected activity
|
|
US4986988A
(en)
|
1989-05-18 |
1991-01-22 |
Arizona Board Of Regents |
Isolation and structural elucidation of the cytostatic linear depsipeptides dolastatin 13 and dehydrodolastatin 13
|
|
DE3920358A1
(de)
|
1989-06-22 |
1991-01-17 |
Behringwerke Ag |
Bispezifische und oligospezifische, mono- und oligovalente antikoerperkonstrukte, ihre herstellung und verwendung
|
|
US5202422A
(en)
|
1989-10-27 |
1993-04-13 |
The Scripps Research Institute |
Compositions containing plant-produced glycopolypeptide multimers, multimeric proteins and method of their use
|
|
US5138036A
(en)
|
1989-11-13 |
1992-08-11 |
Arizona Board Of Regents Acting On Behalf Of Arizona State University |
Isolation and structural elucidation of the cytostatic cyclodepsipeptide dolastatin 14
|
|
US5780225A
(en)
|
1990-01-12 |
1998-07-14 |
Stratagene |
Method for generating libaries of antibody genes comprising amplification of diverse antibody DNAs and methods for using these libraries for the production of diverse antigen combining molecules
|
|
WO1991010737A1
(en)
|
1990-01-11 |
1991-07-25 |
Molecular Affinities Corporation |
Production of antibodies using gene libraries
|
|
EP1690934A3
(en)
|
1990-01-12 |
2008-07-30 |
Abgenix, Inc. |
Generation of xenogeneic antibodies
|
|
EP0513209A4
(en)
|
1990-01-26 |
1993-08-25 |
Us Commerce |
A method for quantitatively measuring collagenase
|
|
US5427908A
(en)
|
1990-05-01 |
1995-06-27 |
Affymax Technologies N.V. |
Recombinant library screening methods
|
|
GB9015198D0
(en)
|
1990-07-10 |
1990-08-29 |
Brien Caroline J O |
Binding substance
|
|
US5770429A
(en)
|
1990-08-29 |
1998-06-23 |
Genpharm International, Inc. |
Transgenic non-human animals capable of producing heterologous antibodies
|
|
US5698426A
(en)
|
1990-09-28 |
1997-12-16 |
Ixsys, Incorporated |
Surface expression libraries of heteromeric receptors
|
|
CA2405246A1
(en)
|
1990-12-03 |
1992-06-11 |
Genentech, Inc. |
Enrichment method for variant proteins with alterred binding properties
|
|
DK0580737T3
(da)
|
1991-04-10 |
2004-11-01 |
Scripps Research Inst |
Heterodimere receptorbiblioteker ved anvendelse af phagemider
|
|
ATE185424T1
(de)
|
1991-07-29 |
1999-10-15 |
Serex Inc |
Differentielle bindungsaffinitäten und darauf beruhende dissoziationstestverfahren
|
|
GB9121835D0
(en)
|
1991-10-15 |
1991-11-27 |
Smithkline Beecham Plc |
Pharmaceuticals
|
|
DE69232137T2
(de)
|
1991-11-25 |
2002-05-29 |
Enzon Inc |
Multivalente antigen-bindende proteine
|
|
ES2341666T3
(es)
|
1991-12-02 |
2010-06-24 |
Medimmune Limited |
Produccion de autoanticuerpos de repertorios de segmentos de anticue rpos expresados en la superficie de fagos.
|
|
US5733743A
(en)
|
1992-03-24 |
1998-03-31 |
Cambridge Antibody Technology Limited |
Methods for producing members of specific binding pairs
|
|
US5376313A
(en)
|
1992-03-27 |
1994-12-27 |
Abbott Laboratories |
Injection molding a plastic assay cuvette having low birefringence
|
|
EP0563485A1
(en)
|
1992-03-30 |
1993-10-06 |
Schering-Plough |
In vitro generation of human dendritic cells and uses thereof
|
|
US5324634A
(en)
|
1992-03-31 |
1994-06-28 |
The Research Foundation Of State University Of New York |
Diagnostic tests measuring gelatinase/inhibitor complexes for detection of aggressive and metastatic cancer
|
|
EP1362913B1
(en)
|
1992-10-30 |
2006-01-25 |
The General Hospital Corporation |
Interaction trap system for isolating proteins
|
|
US5837821A
(en)
|
1992-11-04 |
1998-11-17 |
City Of Hope |
Antibody construct
|
|
US5635483A
(en)
|
1992-12-03 |
1997-06-03 |
Arizona Board Of Regents Acting On Behalf Of Arizona State University |
Tumor inhibiting tetrapeptide bearing modified phenethyl amides
|
|
US6034065A
(en)
|
1992-12-03 |
2000-03-07 |
Arizona Board Of Regents |
Elucidation and synthesis of antineoplastic tetrapeptide phenethylamides of dolastatin 10
|
|
CA2153387A1
(en)
|
1993-01-07 |
1994-07-21 |
Hubert Koester |
Dna sequencing by mass spectrometry
|
|
US5410024A
(en)
|
1993-01-21 |
1995-04-25 |
Arizona Board Of Regents Acting On Behalf Of Arizona State University |
Human cancer inhibitory pentapeptide amides
|
|
US5780588A
(en)
|
1993-01-26 |
1998-07-14 |
Arizona Board Of Regents |
Elucidation and synthesis of selected pentapeptides
|
|
US6214345B1
(en)
|
1993-05-14 |
2001-04-10 |
Bristol-Myers Squibb Co. |
Lysosomal enzyme-cleavable antitumor drug conjugates
|
|
US5837832A
(en)
|
1993-06-25 |
1998-11-17 |
Affymetrix, Inc. |
Arrays of nucleic acid probes on biological chips
|
|
US5498531A
(en)
|
1993-09-10 |
1996-03-12 |
President And Fellows Of Harvard College |
Intron-mediated recombinant techniques and reagents
|
|
JPH09507121A
(ja)
|
1993-10-26 |
1997-07-22 |
アフィマックス テクノロジーズ ナームロゼ ベノートスハップ |
生物学的チップ上の核酸プローブアレー
|
|
EP0733070A1
(en)
|
1993-12-08 |
1996-09-25 |
Genzyme Corporation |
Process for generating specific antibodies
|
|
PT1231268E
(pt)
|
1994-01-31 |
2005-11-30 |
Univ Boston |
Bancos de anticorpos policlonais
|
|
US6015880A
(en)
|
1994-03-16 |
2000-01-18 |
California Institute Of Technology |
Method and substrate for performing multiple sequential reactions on a matrix
|
|
US5508463A
(en)
|
1994-03-17 |
1996-04-16 |
Trustees Of The University Of Pennsylvania |
α-aminophosphonates
|
|
US5516637A
(en)
|
1994-06-10 |
1996-05-14 |
Dade International Inc. |
Method involving display of protein binding pairs on the surface of bacterial pili and bacteriophage
|
|
US5807522A
(en)
|
1994-06-17 |
1998-09-15 |
The Board Of Trustees Of The Leland Stanford Junior University |
Methods for fabricating microarrays of biological samples
|
|
US5504191A
(en)
|
1994-08-01 |
1996-04-02 |
Arizona Board Of Regents Acting On Behalf Of Arizona State University |
Human cancer inhibitory pentapeptide methyl esters
|
|
US5521284A
(en)
|
1994-08-01 |
1996-05-28 |
Arizona Board Of Regents Acting On Behalf Of Arizona State University |
Human cancer inhibitory pentapeptide amides and esters
|
|
US5530097A
(en)
|
1994-08-01 |
1996-06-25 |
Arizona Board Of Regents Acting On Behalf Of Arizona State University |
Human cancer inhibitory peptide amides
|
|
US5554725A
(en)
|
1994-09-14 |
1996-09-10 |
Arizona Board Of Regents Acting On Behalf Of Arizona State University |
Synthesis of dolastatin 15
|
|
US5599902A
(en)
|
1994-11-10 |
1997-02-04 |
Arizona Board Of Regents Acting On Behalf Of Arizona State University |
Cancer inhibitory peptides
|
|
US5663149A
(en)
|
1994-12-13 |
1997-09-02 |
Arizona Board Of Regents Acting On Behalf Of Arizona State University |
Human cancer inhibitory pentapeptide heterocyclic and halophenyl amides
|
|
JPH0987299A
(ja)
*
|
1995-07-14 |
1997-03-31 |
Fuji Yakuhin Kogyo Kk |
Mmp−2活性化因子に特異的なモノクローナル抗体
|
|
US5902582A
(en)
|
1995-09-05 |
1999-05-11 |
Chiron Corporation |
Use of TFPI inhibitor for treatment of cancer
|
|
WO1997023782A1
(en)
|
1995-12-22 |
1997-07-03 |
Abbott Laboratories |
Fluorescence polarization immunoassay diagnostic method
|
|
JP2978435B2
(ja)
|
1996-01-24 |
1999-11-15 |
チッソ株式会社 |
アクリロキシプロピルシランの製造方法
|
|
US6811995B1
(en)
|
1996-04-26 |
2004-11-02 |
Children's Medical Center Corporation |
Non-invasive enzyme screen for cancer
|
|
US5885529A
(en)
|
1996-06-28 |
1999-03-23 |
Dpc Cirrus, Inc. |
Automated immunoassay analyzer
|
|
US6130237A
(en)
|
1996-09-12 |
2000-10-10 |
Cancer Research Campaign Technology Limited |
Condensed N-aclyindoles as antitumor agents
|
|
US6946439B2
(en)
|
1997-02-06 |
2005-09-20 |
Entre Med, Inc. |
Compositions and methods for inhibiting cellular proliferation comprising TFPI fragments
|
|
DE69832158T2
(de)
|
1997-02-25 |
2006-08-10 |
Arizona Board Of Regents, Tempe |
Isolierung und strukturelle aufklärung der kryostatischen linearen und cyclo-depsipeptide dolastatin 16, dolastatin 17, und dolastatin 18
|
|
US5888809A
(en)
|
1997-05-01 |
1999-03-30 |
Icos Corporation |
Hamster EF-1α transcriptional regulatory DNA
|
|
DE19736691A1
(de)
|
1997-08-22 |
1999-02-25 |
Michael Prof Dr Med Giesing |
Verfahren zur Charakterisierung und Identifizierung disseminierter und metastasierter Krebszellen
|
|
US6323315B1
(en)
|
1999-09-10 |
2001-11-27 |
Basf Aktiengesellschaft |
Dolastatin peptides
|
|
ATE400813T1
(de)
|
1999-09-10 |
2008-07-15 |
Takashi Muramatsu |
Tumormarker für frühes krebsstadium
|
|
US7632983B2
(en)
|
2000-07-31 |
2009-12-15 |
Biolex Therapeutics, Inc. |
Expression of monoclonal antibodies in duckweed
|
|
CA2416732C
(en)
|
2000-08-02 |
2016-02-09 |
Brad St. Croix |
Endothelial cell expression patterns
|
|
US20030133939A1
(en)
|
2001-01-17 |
2003-07-17 |
Genecraft, Inc. |
Binding domain-immunoglobulin fusion proteins
|
|
US7713705B2
(en)
|
2002-12-24 |
2010-05-11 |
Biosite, Inc. |
Markers for differential diagnosis and methods of use thereof
|
|
JP4406206B2
(ja)
*
|
2001-04-24 |
2010-01-27 |
バイエル コーポレーション |
ヒトtimp−1抗体
|
|
US20030083263A1
(en)
|
2001-04-30 |
2003-05-01 |
Svetlana Doronina |
Pentapeptide compounds and uses related thereto
|
|
US6884869B2
(en)
|
2001-04-30 |
2005-04-26 |
Seattle Genetics, Inc. |
Pentapeptide compounds and uses related thereto
|
|
WO2003001983A2
(en)
|
2001-06-28 |
2003-01-09 |
Mount Sinai School Of Medicine Of New York University |
Methods for diagnosing and treating a disease mediated by decreased mmp-2 function
|
|
WO2003048734A2
(en)
|
2001-12-03 |
2003-06-12 |
Oncomedx, Inc. |
Detection of matrix metalloproteinase rna in plasma and serum
|
|
US20040005294A1
(en)
*
|
2002-02-25 |
2004-01-08 |
Ho-Young Lee |
IGFBP-3 in the diagnosis and treatment of cancer
|
|
US20040132101A1
(en)
|
2002-09-27 |
2004-07-08 |
Xencor |
Optimized Fc variants and methods for their generation
|
|
SI1545613T1
(sl)
|
2002-07-31 |
2011-11-30 |
Seattle Genetics Inc |
Avristatinski konjugati in njihova uporaba za zdravljenje raka avtoimunske bolezni ali infekcijskebolezni
|
|
AU2003289716A1
(en)
|
2002-09-12 |
2004-04-30 |
Incyte Corporation |
Molecules for diagnostics and therapeutics
|
|
US20060024692A1
(en)
|
2002-09-30 |
2006-02-02 |
Oncotherapy Science, Inc. |
Method for diagnosing non-small cell lung cancers
|
|
US7361740B2
(en)
|
2002-10-15 |
2008-04-22 |
Pdl Biopharma, Inc. |
Alteration of FcRn binding affinities or serum half-lives of antibodies by mutagenesis
|
|
US7960512B2
(en)
|
2003-01-09 |
2011-06-14 |
Macrogenics, Inc. |
Identification and engineering of antibodies with variant Fc regions and methods of using same
|
|
DE10316701A1
(de)
|
2003-04-09 |
2004-11-04 |
Hinzmann, Bernd, Dr. |
Humane Nukleinsäuresequenzen aus Bronchialkarzinomen
|
|
EP1639090A4
(en)
|
2003-06-09 |
2008-04-16 |
Univ Michigan |
COMPOSITIONS AND METHODS OF TREATMENT AND DIAGNOSIS OF CANCER
|
|
US7498298B2
(en)
|
2003-11-06 |
2009-03-03 |
Seattle Genetics, Inc. |
Monomethylvaline compounds capable of conjugation to ligands
|
|
US20050272061A1
(en)
*
|
2004-02-19 |
2005-12-08 |
Seattle Genetics, Inc. |
Expression profiling in non-small cell lung cancer
|
|
CA2588057A1
(en)
|
2004-10-12 |
2006-04-20 |
John Wayne Cancer Institute |
Treatment of cancer and compositions
|
|
US20060235034A1
(en)
|
2004-11-01 |
2006-10-19 |
Nouri Neamati |
Novel compounds for treatment of cancer and disorders associated with angiogenesis function
|
|
US20060160762A1
(en)
|
2004-12-13 |
2006-07-20 |
Children's Medical Center Corporation |
Methods for the treatment, diagnosis, and prognosis of cancer
|
|
WO2006074367A2
(en)
|
2005-01-05 |
2006-07-13 |
Sloan-Kettering Institute For Cancer Research |
Method of predicting and reducing risk of metastasis of breast cancer to lung
|
|
WO2006080597A1
(en)
*
|
2005-01-31 |
2006-08-03 |
Digital Genomics Inc. |
Markers for the diagnosis of lung cancer
|
|
EP1871911A2
(en)
*
|
2005-04-07 |
2008-01-02 |
Chiron Corporation |
Cancer-related genes (prlr)
|
|
ATE502048T1
(de)
|
2005-04-22 |
2011-04-15 |
Univ Washington |
Fluoreszentes chlorotoxinkonjugat und verfahren zur intraoperativen sichtbarmachung von krebs
|
|
EP1957985A4
(en)
*
|
2005-07-21 |
2010-01-27 |
Univ Wayne State |
INCOMACY WITH ASBEST, PLEURAMESOTHELIOM AND OSTEOPONTIN SERUM CONCENTRATIONS
|
|
US9347945B2
(en)
|
2005-12-22 |
2016-05-24 |
Abbott Molecular Inc. |
Methods and marker combinations for screening for predisposition to lung cancer
|
|
EP1969363B1
(en)
|
2005-12-22 |
2016-11-30 |
Abbott Molecular Inc. |
Methods and marker combinations for screening for predisposition to lung cancer
|
|
US20080133141A1
(en)
|
2005-12-22 |
2008-06-05 |
Frost Stephen J |
Weighted Scoring Methods and Use Thereof in Screening
|
|
BRPI0709425A2
(pt)
*
|
2006-03-29 |
2011-07-12 |
Genentech, Inc. |
uso de um antagonista do vegf e método in vitro para diagnosticar um tumor resistente
|
|
WO2007140352A2
(en)
|
2006-05-26 |
2007-12-06 |
Invitrogen Corporation |
Plasma membrane and secreted cancer biomarkers
|
|
EP1892303A1
(en)
|
2006-08-22 |
2008-02-27 |
Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. |
Methods for identifying therapeutical targets in tumors and for determining and targeting angiogenesis and hemostasis related to adenocarcinomas of the lung
|
|
WO2009013075A2
(en)
|
2007-06-19 |
2009-01-29 |
Dublin City University |
Markers for invasion in breast and lung carcinoma
|
|
US20090004105A1
(en)
|
2007-06-27 |
2009-01-01 |
Zhen Cheng |
Molecular imaging of matrix metalloproteinase expression using labeled chlorotoxin
|
|
US20090123439A1
(en)
|
2007-11-09 |
2009-05-14 |
The Jackson Laboratory |
Diagnostic and prognosis methods for cancer stem cells
|
|
US7892760B2
(en)
*
|
2007-11-19 |
2011-02-22 |
Celera Corporation |
Lung cancer markers, and uses thereof
|
|
WO2009079581A1
(en)
|
2007-12-17 |
2009-06-25 |
Dyax Corp. |
Evaluating mmp expression in patient stratification and other therapeutic, diagnostic and prognostic methods for cancer
|