JP2011525538A5 - - Google Patents
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- Publication number
- JP2011525538A5 JP2011525538A5 JP2011516617A JP2011516617A JP2011525538A5 JP 2011525538 A5 JP2011525538 A5 JP 2011525538A5 JP 2011516617 A JP2011516617 A JP 2011516617A JP 2011516617 A JP2011516617 A JP 2011516617A JP 2011525538 A5 JP2011525538 A5 JP 2011525538A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- alkyl
- cycloalkyl
- och
- chr
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 17
- 150000001875 compounds Chemical class 0.000 claims 17
- 229910052739 hydrogen Inorganic materials 0.000 claims 17
- 229910052736 halogen Inorganic materials 0.000 claims 13
- 150000002367 halogens Chemical class 0.000 claims 13
- 229910052731 fluorine Inorganic materials 0.000 claims 12
- 125000000753 cycloalkyl group Chemical group 0.000 claims 9
- 229910052801 chlorine Inorganic materials 0.000 claims 8
- 125000000217 alkyl group Chemical group 0.000 claims 7
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 7
- 125000004076 pyridyl group Chemical group 0.000 claims 7
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims 6
- 125000003118 aryl group Chemical group 0.000 claims 6
- 229910052760 oxygen Inorganic materials 0.000 claims 6
- 239000008194 pharmaceutical composition Substances 0.000 claims 6
- 229910052717 sulfur Inorganic materials 0.000 claims 6
- 125000000335 thiazolyl group Chemical group 0.000 claims 6
- 125000001072 heteroaryl group Chemical group 0.000 claims 5
- 239000000203 mixture Substances 0.000 claims 5
- 125000002971 oxazolyl group Chemical group 0.000 claims 5
- 125000000168 pyrrolyl group Chemical group 0.000 claims 5
- 125000001424 substituent group Chemical group 0.000 claims 5
- 125000001544 thienyl group Chemical group 0.000 claims 5
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 claims 4
- 229910052794 bromium Inorganic materials 0.000 claims 4
- 125000002541 furyl group Chemical group 0.000 claims 4
- 125000005842 heteroatom Chemical group 0.000 claims 4
- 150000002148 esters Chemical class 0.000 claims 3
- 125000000842 isoxazolyl group Chemical group 0.000 claims 3
- 150000003839 salts Chemical class 0.000 claims 3
- 229910052799 carbon Inorganic materials 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims 2
- 125000001786 isothiazolyl group Chemical group 0.000 claims 2
- 125000002950 monocyclic group Chemical group 0.000 claims 2
- 239000012453 solvate Substances 0.000 claims 2
- 102000003734 Voltage-Gated Potassium Channels Human genes 0.000 claims 1
- 108090000013 Voltage-Gated Potassium Channels Proteins 0.000 claims 1
- 230000004913 activation Effects 0.000 claims 1
- 125000003342 alkenyl group Chemical group 0.000 claims 1
- 125000000304 alkynyl group Chemical group 0.000 claims 1
- 125000004432 carbon atom Chemical group C* 0.000 claims 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims 1
- 125000000392 cycloalkenyl group Chemical group 0.000 claims 1
- -1 cycloalkyl compound Chemical class 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000035475 disorder Diseases 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 125000004366 heterocycloalkenyl group Chemical group 0.000 claims 1
- 125000002883 imidazolyl group Chemical group 0.000 claims 1
- 229910052757 nitrogen Inorganic materials 0.000 claims 1
- 125000005412 pyrazyl group Chemical group 0.000 claims 1
- 125000000714 pyrimidinyl group Chemical group 0.000 claims 1
- 229920006395 saturated elastomer Polymers 0.000 claims 1
- 239000002904 solvent Substances 0.000 claims 1
- KAWULRQIBQZKKV-UHFFFAOYSA-N CC(C)(C)CC(Nc(c(C)c1)c(C)cc1OCc(cc1F)ccc1F)=O Chemical compound CC(C)(C)CC(Nc(c(C)c1)c(C)cc1OCc(cc1F)ccc1F)=O KAWULRQIBQZKKV-UHFFFAOYSA-N 0.000 description 1
- YKGRRFCEBXXBBC-UHFFFAOYSA-N CCCc1ccc(COc(cc2C)cc(C)c2NC(CC(C)(C)C)=O)c(F)c1 Chemical compound CCCc1ccc(COc(cc2C)cc(C)c2NC(CC(C)(C)C)=O)c(F)c1 YKGRRFCEBXXBBC-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US7530708P | 2008-06-24 | 2008-06-24 | |
| US61/075,307 | 2008-06-24 | ||
| PCT/US2009/048504 WO2010008894A1 (en) | 2008-06-24 | 2009-06-24 | Benzyloxy anilide derivatives useful as potassium channel modulators |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2011525538A JP2011525538A (ja) | 2011-09-22 |
| JP2011525538A5 true JP2011525538A5 (enExample) | 2013-03-21 |
Family
ID=41448228
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011516617A Pending JP2011525538A (ja) | 2008-06-24 | 2009-06-24 | カリウムチャネルモジュレーターとして有用なベンジルオキシアニリド誘導体 |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US8188314B2 (enExample) |
| EP (1) | EP2310369A4 (enExample) |
| JP (1) | JP2011525538A (enExample) |
| AU (1) | AU2009271302A1 (enExample) |
| CA (1) | CA2728915A1 (enExample) |
| MX (1) | MX2010014461A (enExample) |
| WO (1) | WO2010008894A1 (enExample) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2844639A4 (en) | 2012-04-30 | 2015-12-23 | Scifluor Life Sciences Llc | FLUORINATED DERIVATIVES OF 2-AMINO-4- (BENZYLAMINO) PHENYLCARBAMATE |
| CN103508943B (zh) * | 2012-06-29 | 2017-06-09 | 江苏先声药业有限公司 | 作为钾通道调节剂的化合物 |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5533409B2 (enExample) * | 1972-04-15 | 1980-08-30 | ||
| US3995041A (en) * | 1975-10-30 | 1976-11-30 | Miles Laboratories, Inc. | Derivatives of 2-substituted-hydroxyanilino-hexahydro-2H-benzo[α]quinolizines |
| JPS5953917B2 (ja) * | 1976-07-23 | 1984-12-27 | 武田薬品工業株式会社 | テトラヒドロイソフタルイミド誘導体およびその製造方法 |
| US4180509A (en) * | 1977-07-01 | 1979-12-25 | Merrell Toraude Et Compagnie | α-Ethynyl tryptophanes |
| JPS6072787A (ja) * | 1983-09-30 | 1985-04-24 | Hodogaya Chem Co Ltd | 感熱記録材料 |
| FR2675504B1 (fr) * | 1991-04-16 | 1995-01-27 | Delalande Sa | Derives d'aryl-3 oxazolidinone, leur procede de preparation et leur application en therapeutique. |
| IL111002A (en) * | 1993-09-22 | 1998-09-24 | Glaxo Group Ltd | Piperidine derivatives their preparation and pharmaceutical compositions containing them |
| CA2262786A1 (en) * | 1996-09-10 | 1998-03-19 | Pharmacia & Upjohn Company | 8-hydroxy-7-substituted quinolines as anti-viral agents |
| PE68599A1 (es) * | 1997-04-25 | 1999-09-26 | Smithkline Beecham Corp | Inhibidores de proteasas |
| JP4721386B2 (ja) * | 2001-07-10 | 2011-07-13 | 第一三共株式会社 | 新規ガランタミン類縁体 |
| PT1511718E (pt) * | 2002-05-29 | 2009-06-12 | Hoffmann La Roche | Derivados de n-acilaminobenzeno como inibidores selectivos de monoamina-oxidase b |
| GB0221246D0 (en) * | 2002-09-13 | 2002-10-23 | Astrazeneca Ab | Compounds |
| US7718692B2 (en) * | 2004-02-13 | 2010-05-18 | Carson John R | Hetero-substituted acetanilide derivatives as analgesic agents |
| JP2006523196A (ja) * | 2003-03-11 | 2006-10-12 | ニューロサーチ、アクティーゼルスカブ | 新規ｋｃｎｑチャネルを調節する化合物及びその医薬用途 |
| AR043507A1 (es) * | 2003-03-14 | 2005-08-03 | Lundbeck & Co As H | Derivados de anilina sustituidos y composiciones farmaceuticas |
| US7338950B2 (en) * | 2003-10-07 | 2008-03-04 | Renovis, Inc. | Amide compounds as ion channel ligands and uses thereof |
| EP1684762A4 (en) * | 2003-11-13 | 2009-06-17 | Ambit Biosciences Corp | UREA DERIVATIVES AS MODULATORS OF KINASE |
| WO2006022442A1 (ja) * | 2004-08-24 | 2006-03-02 | Santen Pharmaceutical Co., Ltd. | ジヒドロオロテートデヒドロゲナーゼ阻害活性を有する新規複素環アミド誘導体 |
| UA89503C2 (uk) * | 2004-09-13 | 2010-02-10 | Х. Луннбек А/С | Заміщені похідні аніліну |
| JP2009256208A (ja) * | 2006-08-17 | 2009-11-05 | Dainippon Sumitomo Pharma Co Ltd | フタリド誘導体またはその薬学的に許容される塩 |
| AU2007288253B2 (en) * | 2006-08-23 | 2013-05-02 | Xenon Pharmaceuticals Inc. | Derivatives of 4-(N-azacycloalkyl) anilides as potassium channel modulators |
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2009
- 2009-06-24 AU AU2009271302A patent/AU2009271302A1/en not_active Abandoned
- 2009-06-24 MX MX2010014461A patent/MX2010014461A/es not_active Application Discontinuation
- 2009-06-24 JP JP2011516617A patent/JP2011525538A/ja active Pending
- 2009-06-24 WO PCT/US2009/048504 patent/WO2010008894A1/en not_active Ceased
- 2009-06-24 US US12/491,055 patent/US8188314B2/en not_active Expired - Fee Related
- 2009-06-24 EP EP09798525.3A patent/EP2310369A4/en not_active Withdrawn
- 2009-06-24 CA CA2728915A patent/CA2728915A1/en not_active Abandoned
-
2012
- 2012-05-29 US US13/483,018 patent/US8492588B2/en not_active Expired - Fee Related