JP2011525533A5 - - Google Patents
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- Publication number
- JP2011525533A5 JP2011525533A5 JP2011516521A JP2011516521A JP2011525533A5 JP 2011525533 A5 JP2011525533 A5 JP 2011525533A5 JP 2011516521 A JP2011516521 A JP 2011516521A JP 2011516521 A JP2011516521 A JP 2011516521A JP 2011525533 A5 JP2011525533 A5 JP 2011525533A5
- Authority
- JP
- Japan
- Prior art keywords
- compound
- structural formula
- stereoisomerically pure
- mixture
- substantially stereoisomerically
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- -1 amino acid compounds Chemical class 0.000 claims 33
- 150000001875 compounds Chemical class 0.000 claims 33
- 239000000203 mixture Substances 0.000 claims 13
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 8
- 150000003839 salts Chemical class 0.000 claims 6
- 239000002253 acid Substances 0.000 claims 4
- 238000004519 manufacturing process Methods 0.000 claims 4
- XFXPMWWXUTWYJX-UHFFFAOYSA-N Cyanide Chemical compound N#[C-] XFXPMWWXUTWYJX-UHFFFAOYSA-N 0.000 claims 3
- 238000002360 preparation method Methods 0.000 claims 3
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 1
- 150000004677 hydrates Chemical class 0.000 claims 1
- 0 C1N=CC2N*NC12 Chemical compound C1N=CC2N*NC12 0.000 description 21
- PRSVJIWYTOZNIT-UHNVWZDZSA-N C1[C@@H]2C=NC[C@H]12 Chemical compound C1[C@@H]2C=NC[C@H]12 PRSVJIWYTOZNIT-UHNVWZDZSA-N 0.000 description 1
- LIIIOENFQCDKSQ-CRCLSJGQSA-N ClC1([C@@H]2C=NC[C@@H]2C1)Cl Chemical compound ClC1([C@@H]2C=NC[C@@H]2C1)Cl LIIIOENFQCDKSQ-CRCLSJGQSA-N 0.000 description 1
- UDEZWFKMDWBDLV-ZLUOBGJFSA-N NC(NC[C@H]1[C@H]2C=NC[C@H]12)=N Chemical compound NC(NC[C@H]1[C@H]2C=NC[C@H]12)=N UDEZWFKMDWBDLV-ZLUOBGJFSA-N 0.000 description 1
- BWZVLKVCHYWXFP-WHFBIAKZSA-N OC(C(C1)([C@@H]2[C@@H]1C=NC2)C(O)=O)=O Chemical compound OC(C(C1)([C@@H]2[C@@H]1C=NC2)C(O)=O)=O BWZVLKVCHYWXFP-WHFBIAKZSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US7524308P | 2008-06-24 | 2008-06-24 | |
| US61/075,243 | 2008-06-24 | ||
| PCT/US2009/048255 WO2010008828A2 (en) | 2008-06-24 | 2009-06-23 | Biocatalytic processes for the preparation of substantially stereomerically pure fused bicyclic proline compounds |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2011525533A JP2011525533A (ja) | 2011-09-22 |
| JP2011525533A5 true JP2011525533A5 (https=) | 2012-07-26 |
Family
ID=41550950
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011516521A Pending JP2011525533A (ja) | 2008-06-24 | 2009-06-23 | 実質的に立体異性的に純粋な縮合二環式プロリン化合物の調製のための生体触媒法 |
Country Status (10)
| Country | Link |
|---|---|
| US (4) | US8178333B2 (https=) |
| EP (2) | EP2307419B1 (https=) |
| JP (1) | JP2011525533A (https=) |
| KR (1) | KR20110048509A (https=) |
| CN (2) | CN102131813B (https=) |
| AU (1) | AU2009271325A1 (https=) |
| CA (1) | CA2728226A1 (https=) |
| ES (1) | ES2438576T3 (https=) |
| MX (1) | MX2010014500A (https=) |
| WO (1) | WO2010008828A2 (https=) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7811283B2 (en) * | 2003-11-19 | 2010-10-12 | Covidien Ag | Open vessel sealing instrument with hourglass cutting mechanism and over-ratchet safety |
| MX2010014500A (es) * | 2008-06-24 | 2011-05-30 | Codexis Inc | Procedimientos biocataliticos para la preparacion de compuestos de prolina biciclica fusionada sustancialmente estereomericamente puros. |
| US8828930B2 (en) | 2009-07-30 | 2014-09-09 | Merck Sharp & Dohme Corp. | Hepatitis C virus NS3 protease inhibitors |
| US8686145B2 (en) | 2010-02-25 | 2014-04-01 | Vereniging Voor Christelijk Hoger Onderwijs, Wetenschappelijk Onderzoek en Patientenzorg C/O Technology Transfer Officer VU & Vumc | Process for the preparation of α-acyloxy β-formamido amides |
| JP2013010732A (ja) | 2011-06-03 | 2013-01-17 | Sumitomo Chemical Co Ltd | プロリン化合物の製造方法 |
| CN103450066B (zh) * | 2012-05-30 | 2017-03-15 | 博瑞生物医药（苏州）股份有限公司 | 特拉匹韦中间体的制备方法 |
| AR091192A1 (es) | 2012-05-30 | 2015-01-21 | Chemo Iberica Sa | Procedimiento multicomponente para la preparacion de compuestos biciclicos |
| ITMI20122205A1 (it) * | 2012-12-20 | 2014-06-21 | Dipharma Francis Srl | Sintesi di un intermedio di un inibitore delle proteasi virali |
| WO2014096374A1 (en) | 2012-12-21 | 2014-06-26 | Sandoz Ag | Process for the synthesis of pyrrolidines and pyrroles |
| ITMI20130706A1 (it) * | 2013-04-30 | 2014-10-31 | Dipharma Francis Srl | Procedimento per la preparazione di un inibitore delle proteasi virali e suoi intermedi |
| CN104292146B (zh) * | 2013-06-24 | 2017-04-26 | 上海医药工业研究院 | 特拉匹韦中间体及其制备方法 |
| RU2016116253A (ru) | 2013-09-27 | 2017-11-01 | Кодексис, Инк. | Автоматизированный скрининг вариантов фермента |
| CN105441401B (zh) * | 2014-09-01 | 2019-11-08 | 上海弈柯莱生物医药科技有限公司 | 一种单胺氧化酶及其在合成手性氮杂双环化合物中的应用 |
| CN105624128B (zh) * | 2014-11-26 | 2020-03-17 | 上海弈柯莱生物医药科技有限公司 | 一种固定化单胺氧化酶及其在合成手性氮杂双环化合物中的应用 |
| JP7674810B2 (ja) * | 2017-02-03 | 2025-05-12 | アンティドートゥ・セラピューティクス・インコーポレイテッド | 新規ニコチン分解酵素変異体 |
| CN115927216B (zh) * | 2021-08-10 | 2025-03-25 | 深圳瑞德林生物技术有限公司 | 一种s-尼古丁的制备方法 |
| CN114292825B (zh) * | 2021-12-17 | 2023-08-18 | 武汉大学 | 一种托品酮的合成方法 |
| CN114317631B (zh) * | 2021-12-17 | 2023-11-07 | 武汉大学 | 单胺氧化酶在制备托品酮中的应用 |
| CN116731991A (zh) * | 2022-03-10 | 2023-09-12 | 青岛清原化合物有限公司 | 单胺氧化酶及其应用 |
| WO2023173058A2 (en) * | 2022-03-11 | 2023-09-14 | Codexis, Inc. | Engineered monoamine oxidases for the preparation of stereomerically pure fused bicyclic proline compounds |
| JP2025510621A (ja) * | 2022-03-31 | 2025-04-15 | 青島清原化合物有限公司 | モノアミン酸化酵素及びその応用 |
| CN114774382A (zh) * | 2022-04-07 | 2022-07-22 | 扬州联澳生物医药有限公司 | 立体选择性制备6,6-二甲基-3-氮杂双环[3.1.0]己烯化合物的方法 |
| CN114751853B (zh) * | 2022-04-11 | 2023-10-13 | 扬州联澳生物医药有限公司 | 6,6-二甲基-3-氮杂双环[3.1.0]己烷化合物的制备方法 |
| CN114958938B (zh) * | 2022-05-13 | 2023-12-08 | 金达威生物技术(江苏)有限公司 | 一种稠合二环脯氨酸甲酯盐酸盐的制备方法 |
| CN114736882B (zh) * | 2022-05-20 | 2023-09-22 | 苏州百福安酶技术有限公司 | 一种单胺氧化酶及其应用 |
| CN116064444B (zh) * | 2022-08-24 | 2025-05-06 | 长兴制药股份有限公司 | 一种单胺氧化酶及波普瑞韦双环脯氨酸片段的制备方法 |
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| DE2962910D1 (en) * | 1978-10-27 | 1982-07-08 | Shell Int Research | A process for the preparation of 3-azabicyclo(3.1.0)hexane derivatives and modifications thereof |
| CA1117128A (en) * | 1978-10-27 | 1982-01-26 | Derek A. Wood | 2-cyano-3-azabicyclo(3.1.0)hexane |
| LU88621I2 (fr) * | 1980-10-23 | 1995-09-01 | Schering Corp | Sandopril |
| DE3211676A1 (de) | 1982-03-30 | 1983-10-06 | Hoechst Ag | Neue derivate von cycloalka (c) pyrrol-carbonsaeuren, verfahren zu ihrer herstellung, diese enthaltende mittel und deren verwendung sowie neue cycloalka (c) pyrrol-carbonsaeuren als zwischenstufen und verfahren zu deren herstellung |
| DE3322530A1 (de) * | 1983-06-23 | 1985-01-10 | Hoechst Ag, 6230 Frankfurt | Verfahren zur herstellung von mono-, bi- und tricyclischen aminosaeuren |
| DE69133402T2 (de) | 1990-04-04 | 2004-11-11 | Chiron Corp. (N.D.Ges.D. Staates Delaware), Emeryville | Protease von hepatitis-c-virus |
| US6117679A (en) | 1994-02-17 | 2000-09-12 | Maxygen, Inc. | Methods for generating polynucleotides having desired characteristics by iterative selection and recombination |
| US5605793A (en) | 1994-02-17 | 1997-02-25 | Affymax Technologies N.V. | Methods for in vitro recombination |
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| US6335160B1 (en) | 1995-02-17 | 2002-01-01 | Maxygen, Inc. | Methods and compositions for polypeptide engineering |
| FI964808A0 (fi) | 1994-06-03 | 1996-12-02 | Novo Nordisk Biotech Inc | Puhdistetut Myceliophthora lakkaasit ja niitä koodaavat nukleiinihapot |
| CN101659926A (zh) | 1994-06-30 | 2010-03-03 | 诺沃奇梅兹有限公司 | 非毒性、非产毒性、非致病性镰孢属表达系统及所用启动子和终止子 |
| FI104465B (fi) | 1995-06-14 | 2000-02-15 | Valio Oy | Proteiinihydrolysaatteja allergioiden hoitamiseksi tai estämiseksi, niiden valmistus ja käyttö |
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| PT1745040E (pt) | 2004-02-23 | 2010-03-08 | Glaxo Group Ltd | Derivados do azabiciclo3.1.0-hexano úteis como moduladores dos receptores d3 da dopamina |
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| WO2007023382A2 (en) * | 2005-08-25 | 2007-03-01 | Pfizer Inc. | Pyrimidine amino pyrazole compounds, potent kinase inhibitors |
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| EP2416765B1 (en) | 2009-04-06 | 2016-03-30 | PTC Therapeutics, Inc. | Hcv inhibitor and therapeutic agent combinations |
| WO2010117936A1 (en) | 2009-04-06 | 2010-10-14 | Schering Corporation | Combinations of a hcv inhibitor such as bicyclic pyrrole derivatives and a therapeutic agent |
-
2009
- 2009-06-23 MX MX2010014500A patent/MX2010014500A/es not_active Application Discontinuation
- 2009-06-23 CN CN200980133157.9A patent/CN102131813B/zh active Active
- 2009-06-23 ES ES09798485.0T patent/ES2438576T3/es active Active
- 2009-06-23 US US12/490,190 patent/US8178333B2/en active Active
- 2009-06-23 KR KR1020117001584A patent/KR20110048509A/ko not_active Withdrawn
- 2009-06-23 EP EP09798485.0A patent/EP2307419B1/en active Active
- 2009-06-23 CA CA2728226A patent/CA2728226A1/en not_active Abandoned
- 2009-06-23 WO PCT/US2009/048255 patent/WO2010008828A2/en not_active Ceased
- 2009-06-23 CN CN2012101130855A patent/CN102816106A/zh active Pending
- 2009-06-23 EP EP20120157520 patent/EP2481737A1/en not_active Withdrawn
- 2009-06-23 AU AU2009271325A patent/AU2009271325A1/en not_active Abandoned
- 2009-06-23 JP JP2011516521A patent/JP2011525533A/ja active Pending
-
2011
- 2011-11-11 US US13/294,930 patent/US8859784B2/en active Active
-
2012
- 2012-03-30 US US13/436,506 patent/US8574876B2/en active Active
- 2012-05-07 US US13/465,735 patent/US20120289709A1/en not_active Abandoned
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