JP2011525533A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2011525533A5 JP2011525533A5 JP2011516521A JP2011516521A JP2011525533A5 JP 2011525533 A5 JP2011525533 A5 JP 2011525533A5 JP 2011516521 A JP2011516521 A JP 2011516521A JP 2011516521 A JP2011516521 A JP 2011516521A JP 2011525533 A5 JP2011525533 A5 JP 2011525533A5
- Authority
- JP
- Japan
- Prior art keywords
- compound
- structural formula
- stereoisomerically pure
- mixture
- substantially stereoisomerically
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- -1 amino acid compounds Chemical class 0.000 claims 33
- 150000001875 compounds Chemical class 0.000 claims 33
- 239000000203 mixture Substances 0.000 claims 13
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 8
- 150000003839 salts Chemical class 0.000 claims 6
- 239000002253 acid Substances 0.000 claims 4
- 238000004519 manufacturing process Methods 0.000 claims 4
- XFXPMWWXUTWYJX-UHFFFAOYSA-N Cyanide Chemical compound N#[C-] XFXPMWWXUTWYJX-UHFFFAOYSA-N 0.000 claims 3
- 238000002360 preparation method Methods 0.000 claims 3
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 1
- 150000004677 hydrates Chemical class 0.000 claims 1
- 0 C1N=CC2N*NC12 Chemical compound C1N=CC2N*NC12 0.000 description 21
- PRSVJIWYTOZNIT-UHNVWZDZSA-N C1[C@@H]2C=NC[C@H]12 Chemical compound C1[C@@H]2C=NC[C@H]12 PRSVJIWYTOZNIT-UHNVWZDZSA-N 0.000 description 1
- LIIIOENFQCDKSQ-CRCLSJGQSA-N ClC1([C@@H]2C=NC[C@@H]2C1)Cl Chemical compound ClC1([C@@H]2C=NC[C@@H]2C1)Cl LIIIOENFQCDKSQ-CRCLSJGQSA-N 0.000 description 1
- UDEZWFKMDWBDLV-ZLUOBGJFSA-N NC(NC[C@H]1[C@H]2C=NC[C@H]12)=N Chemical compound NC(NC[C@H]1[C@H]2C=NC[C@H]12)=N UDEZWFKMDWBDLV-ZLUOBGJFSA-N 0.000 description 1
- BWZVLKVCHYWXFP-WHFBIAKZSA-N OC(C(C1)([C@@H]2[C@@H]1C=NC2)C(O)=O)=O Chemical compound OC(C(C1)([C@@H]2[C@@H]1C=NC2)C(O)=O)=O BWZVLKVCHYWXFP-WHFBIAKZSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US7524308P | 2008-06-24 | 2008-06-24 | |
| US61/075,243 | 2008-06-24 | ||
| PCT/US2009/048255 WO2010008828A2 (en) | 2008-06-24 | 2009-06-23 | Biocatalytic processes for the preparation of substantially stereomerically pure fused bicyclic proline compounds |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2011525533A JP2011525533A (ja) | 2011-09-22 |
| JP2011525533A5 true JP2011525533A5 (https=) | 2012-07-26 |
Family
ID=41550950
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011516521A Pending JP2011525533A (ja) | 2008-06-24 | 2009-06-23 | 実質的に立体異性的に純粋な縮合二環式プロリン化合物の調製のための生体触媒法 |
Country Status (10)
| Country | Link |
|---|---|
| US (4) | US8178333B2 (https=) |
| EP (2) | EP2481737A1 (https=) |
| JP (1) | JP2011525533A (https=) |
| KR (1) | KR20110048509A (https=) |
| CN (2) | CN102816106A (https=) |
| AU (1) | AU2009271325A1 (https=) |
| CA (1) | CA2728226A1 (https=) |
| ES (1) | ES2438576T3 (https=) |
| MX (1) | MX2010014500A (https=) |
| WO (1) | WO2010008828A2 (https=) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7811283B2 (en) * | 2003-11-19 | 2010-10-12 | Covidien Ag | Open vessel sealing instrument with hourglass cutting mechanism and over-ratchet safety |
| CN102816106A (zh) * | 2008-06-24 | 2012-12-12 | 默沙东公司 | 用于制备基本上立体异构纯的稠合二环脯氨酸化合物的生物催化方法 |
| US8828930B2 (en) | 2009-07-30 | 2014-09-09 | Merck Sharp & Dohme Corp. | Hepatitis C virus NS3 protease inhibitors |
| WO2011103933A1 (en) | 2010-02-25 | 2011-09-01 | Vereniging Voor Christelijk Hoger Onderwijs, Wetenschappelijk Onderzoek En Patiëntenzorg | PROCESS FOR THE PREPARATION OF α-ACYLOXY β-FORMAMIDO AMIDES |
| JP2013010732A (ja) | 2011-06-03 | 2013-01-17 | Sumitomo Chemical Co Ltd | プロリン化合物の製造方法 |
| CN103450066B (zh) * | 2012-05-30 | 2017-03-15 | 博瑞生物医药（苏州）股份有限公司 | 特拉匹韦中间体的制备方法 |
| AR091192A1 (es) | 2012-05-30 | 2015-01-21 | Chemo Iberica Sa | Procedimiento multicomponente para la preparacion de compuestos biciclicos |
| ITMI20122205A1 (it) * | 2012-12-20 | 2014-06-21 | Dipharma Francis Srl | Sintesi di un intermedio di un inibitore delle proteasi virali |
| WO2014096374A1 (en) | 2012-12-21 | 2014-06-26 | Sandoz Ag | Process for the synthesis of pyrrolidines and pyrroles |
| ITMI20130706A1 (it) * | 2013-04-30 | 2014-10-31 | Dipharma Francis Srl | Procedimento per la preparazione di un inibitore delle proteasi virali e suoi intermedi |
| CN104292146B (zh) * | 2013-06-24 | 2017-04-26 | 上海医药工业研究院 | 特拉匹韦中间体及其制备方法 |
| US10696964B2 (en) | 2013-09-27 | 2020-06-30 | Codexis, Inc. | Automated screening of enzyme variants |
| CN105441401B (zh) * | 2014-09-01 | 2019-11-08 | 上海弈柯莱生物医药科技有限公司 | 一种单胺氧化酶及其在合成手性氮杂双环化合物中的应用 |
| CN105624128B (zh) * | 2014-11-26 | 2020-03-17 | 上海弈柯莱生物医药科技有限公司 | 一种固定化单胺氧化酶及其在合成手性氮杂双环化合物中的应用 |
| US11597916B2 (en) * | 2017-02-03 | 2023-03-07 | Antidote Therapeutics, Inc. | Nicotine degrading enzyme variants |
| CN115927216B (zh) * | 2021-08-10 | 2025-03-25 | 深圳瑞德林生物技术有限公司 | 一种s-尼古丁的制备方法 |
| CN114317631B (zh) * | 2021-12-17 | 2023-11-07 | 武汉大学 | 单胺氧化酶在制备托品酮中的应用 |
| CN114292825B (zh) * | 2021-12-17 | 2023-08-18 | 武汉大学 | 一种托品酮的合成方法 |
| WO2023169071A1 (zh) * | 2022-03-10 | 2023-09-14 | 青岛清原化合物有限公司 | 单胺氧化酶及其应用 |
| US20230287361A1 (en) * | 2022-03-11 | 2023-09-14 | Codexis, Inc. | Engineered monoamine oxidases for the preparation of stereomerically pure fused bicyclic proline compounds |
| CN116891839A (zh) * | 2022-03-31 | 2023-10-17 | 青岛清原化合物有限公司 | 一种单胺氧化酶及其应用 |
| CN114774382A (zh) * | 2022-04-07 | 2022-07-22 | 扬州联澳生物医药有限公司 | 立体选择性制备6,6-二甲基-3-氮杂双环[3.1.0]己烯化合物的方法 |
| CN114751853B (zh) * | 2022-04-11 | 2023-10-13 | 扬州联澳生物医药有限公司 | 6,6-二甲基-3-氮杂双环[3.1.0]己烷化合物的制备方法 |
| CN114958938B (zh) * | 2022-05-13 | 2023-12-08 | 金达威生物技术(江苏)有限公司 | 一种稠合二环脯氨酸甲酯盐酸盐的制备方法 |
| CN114736882B (zh) * | 2022-05-20 | 2023-09-22 | 苏州百福安酶技术有限公司 | 一种单胺氧化酶及其应用 |
| CN116064444B (zh) * | 2022-08-24 | 2025-05-06 | 长兴制药股份有限公司 | 一种单胺氧化酶及波普瑞韦双环脯氨酸片段的制备方法 |
Family Cites Families (50)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4183857A (en) | 1978-07-06 | 1980-01-15 | Shell Oil Company | 3-Benzyl-3-azabicyclo(3.1.0)hexane-2,4-dione |
| CA1117125A (en) | 1978-03-01 | 1982-01-26 | Ronald F. Mason | 2-cyano-3-azabicyclo¬3.1.0|hexane compounds |
| US4225499A (en) | 1978-07-06 | 1980-09-30 | Shell Oil Company | Process for preparing 3-azabicyclo(3.1.0)hexane-2-carbonitrile |
| CA1116615A (en) * | 1978-09-27 | 1982-01-19 | Ronald F. Mason | Sulfonic acid salt of 2-cyano-3-azabicyclo[3.1.0]hexane |
| CA1117128A (en) * | 1978-10-27 | 1982-01-26 | Derek A. Wood | 2-cyano-3-azabicyclo(3.1.0)hexane |
| EP0010799B1 (en) * | 1978-10-27 | 1982-05-19 | Shell Internationale Researchmaatschappij B.V. | A process for the preparation of 3-azabicyclo(3.1.0)hexane derivatives and modifications thereof |
| ATE20469T1 (de) * | 1980-10-23 | 1986-07-15 | Schering Corp | Carboxyalkyl-dipeptide, verfahren zu ihrer herstellung und diese enthaltende arzneimittel. |
| DE3211676A1 (de) | 1982-03-30 | 1983-10-06 | Hoechst Ag | Neue derivate von cycloalka (c) pyrrol-carbonsaeuren, verfahren zu ihrer herstellung, diese enthaltende mittel und deren verwendung sowie neue cycloalka (c) pyrrol-carbonsaeuren als zwischenstufen und verfahren zu deren herstellung |
| DE3322530A1 (de) * | 1983-06-23 | 1985-01-10 | Hoechst Ag, 6230 Frankfurt | Verfahren zur herstellung von mono-, bi- und tricyclischen aminosaeuren |
| ATE270326T1 (de) | 1990-04-04 | 2004-07-15 | Chiron Corp | Protease von hepatitis-c-virus |
| US6117679A (en) | 1994-02-17 | 2000-09-12 | Maxygen, Inc. | Methods for generating polynucleotides having desired characteristics by iterative selection and recombination |
| US5605793A (en) | 1994-02-17 | 1997-02-25 | Affymax Technologies N.V. | Methods for in vitro recombination |
| US6335160B1 (en) | 1995-02-17 | 2002-01-01 | Maxygen, Inc. | Methods and compositions for polypeptide engineering |
| US5837458A (en) | 1994-02-17 | 1998-11-17 | Maxygen, Inc. | Methods and compositions for cellular and metabolic engineering |
| WO1995033836A1 (en) | 1994-06-03 | 1995-12-14 | Novo Nordisk Biotech, Inc. | Phosphonyldipeptides useful in the treatment of cardiovascular diseases |
| ATE294871T1 (de) | 1994-06-30 | 2005-05-15 | Novozymes Biotech Inc | Nicht-toxisches, nicht-toxigenes, nicht- pathogenes fusarium expressionssystem und darin zu verwendende promotoren und terminatoren |
| FI104465B (fi) | 1995-06-14 | 2000-02-15 | Valio Oy | Proteiinihydrolysaatteja allergioiden hoitamiseksi tai estämiseksi, niiden valmistus ja käyttö |
| DK1036198T3 (da) | 1997-12-08 | 2013-01-02 | California Inst Of Techn | Fremgangsmåde til fremstilling af polynukleotid- og polypeptidsekvenser |
| JPH11253162A (ja) | 1998-03-10 | 1999-09-21 | Mitsubishi Chemical Corp | モノアミンオキシダーゼをコードするｄｎａ |
| US6562958B1 (en) | 1998-06-09 | 2003-05-13 | Genome Therapeutics Corporation | Nucleic acid and amino acid sequences relating to Acinetobacter baumannii for diagnostics and therapeutics |
| US6858018B1 (en) | 1998-09-28 | 2005-02-22 | Vyteris, Inc. | Iontophoretic devices |
| SE521927C2 (sv) | 1998-10-01 | 2003-12-16 | Delsing Jerker | Metod och anordning för interferometrimätning |
| US7504490B1 (en) | 1998-10-16 | 2009-03-17 | Oscient Pharmaceuticals Corporation | Nucleic acid and amino acid sequences relating to Apergillus fumigatus for diagnostics and therapeutics |
| JP4221100B2 (ja) | 1999-01-13 | 2009-02-12 | エルピーダメモリ株式会社 | 半導体装置 |
| EP1272967A2 (en) | 2000-03-30 | 2003-01-08 | Maxygen, Inc. | In silico cross-over site selection |
| US7244721B2 (en) | 2000-07-21 | 2007-07-17 | Schering Corporation | Peptides as NS3-serine protease inhibitors of hepatitis C virus |
| CN1498224A (zh) | 2000-07-21 | 2004-05-19 | ���鹫˾ | 用作丙型肝炎病毒ns3-丝氨酸蛋白酶抑制剂的新型肽 |
| SV2003000617A (es) | 2000-08-31 | 2003-01-13 | Lilly Co Eli | Inhibidores de la proteasa peptidomimetica ref. x-14912m |
| US7214786B2 (en) | 2000-12-14 | 2007-05-08 | Kovalic David K | Nucleic acid molecules and other molecules associated with plants and uses thereof for plant improvement |
| WO2003008379A1 (en) * | 2001-06-08 | 2003-01-30 | Mitsubishi Chemical Corporation | Azasugar compounds |
| AU2002348414B2 (en) | 2001-10-24 | 2009-10-01 | Vertex Pharmaceuticals Incorporated | Inhibitors of serine protease, particularly hepatitis C virus NS3-NS4A protease, incorporating a fused ring system |
| US20040029129A1 (en) | 2001-10-25 | 2004-02-12 | Liangsu Wang | Identification of essential genes in microorganisms |
| US7314974B2 (en) | 2002-02-21 | 2008-01-01 | Monsanto Technology, Llc | Expression of microbial proteins in plants for production of plants with improved properties |
| GB0206415D0 (en) | 2002-03-19 | 2002-05-01 | Glaxo Group Ltd | Deracemisation of amines |
| GB0211418D0 (en) | 2002-05-17 | 2002-06-26 | Glaxo Group Ltd | Compounds |
| EP1633711B1 (en) | 2003-06-17 | 2010-11-24 | Schering Corporation | Process and intermediates for the preparation of (1r,2s,5s)-6,6-dimethyl-3-azabicyclo[3,1,0]hexane-2-carboxylates or salts thereof |
| EP1654354A1 (en) | 2003-08-11 | 2006-05-10 | Codexis, Inc. | Improved ketoreductase polypeptides and related polynucleotides |
| PE20051173A1 (es) | 2004-02-23 | 2006-02-14 | Glaxo Group Ltd | Compuestos azabiciclico (3.1.0) hexanos como moduladores de receptores de dopamina d3 |
| DE602005015834D1 (de) * | 2004-02-27 | 2009-09-17 | Schering Corp | 3,4-(cyclopentyl)kondensierte prolinverbindungen als inhibitoren der ns3-serinprotease des hepatitis-c-virus |
| GB0426661D0 (en) * | 2004-12-06 | 2005-01-05 | Isis Innovation | Pyrrolidine compounds |
| US8399615B2 (en) | 2005-08-19 | 2013-03-19 | Vertex Pharmaceuticals Incorporated | Processes and intermediates |
| WO2007022459A2 (en) | 2005-08-19 | 2007-02-22 | Vertex Pharmaceuticals Incorporated | Processes and intermediates |
| WO2007023382A2 (en) * | 2005-08-25 | 2007-03-01 | Pfizer Inc. | Pyrimidine amino pyrazole compounds, potent kinase inhibitors |
| US20080300251A1 (en) * | 2005-09-05 | 2008-12-04 | Sattigeri Jitendra A | Derivatives of 3-Azabicyclo[3.1.0] Hexane as Dipeptidyl Peptidase-IV Inhibitors |
| JP5247466B2 (ja) | 2005-12-22 | 2013-07-24 | メルク・シャープ・アンド・ドーム・コーポレーション | ６，６−ジメチル−３−アザビシクロ−［３．１．０］−ヘキサン化合物およびその鏡像異性体塩を調製するプロセス |
| MX2009006865A (es) * | 2006-12-20 | 2009-08-20 | Schering Corp | Proceso para la preparacion de compuestos 6,6-dimetil-3-aza-bicicl o-[3.1.0]-hexano utilizando intermediario bisulfitico. |
| JP2011504929A (ja) * | 2007-11-28 | 2011-02-17 | シェーリング コーポレイション | ６，６−ジメチル−３−アザビシクロ［３．１．０］ヘキサンを提供するのに有用な中間体調製のための脱塩化水素化プロセス |
| CN102816106A (zh) * | 2008-06-24 | 2012-12-12 | 默沙东公司 | 用于制备基本上立体异构纯的稠合二环脯氨酸化合物的生物催化方法 |
| WO2010117939A1 (en) | 2009-04-06 | 2010-10-14 | Schering Corporation | Hcv inhibitor and therapeutic agent combinations |
| WO2010117936A1 (en) | 2009-04-06 | 2010-10-14 | Schering Corporation | Combinations of a hcv inhibitor such as bicyclic pyrrole derivatives and a therapeutic agent |
-
2009
- 2009-06-23 CN CN2012101130855A patent/CN102816106A/zh active Pending
- 2009-06-23 CN CN200980133157.9A patent/CN102131813B/zh active Active
- 2009-06-23 US US12/490,190 patent/US8178333B2/en active Active
- 2009-06-23 EP EP20120157520 patent/EP2481737A1/en not_active Withdrawn
- 2009-06-23 ES ES09798485.0T patent/ES2438576T3/es active Active
- 2009-06-23 CA CA2728226A patent/CA2728226A1/en not_active Abandoned
- 2009-06-23 EP EP09798485.0A patent/EP2307419B1/en active Active
- 2009-06-23 WO PCT/US2009/048255 patent/WO2010008828A2/en not_active Ceased
- 2009-06-23 MX MX2010014500A patent/MX2010014500A/es not_active Application Discontinuation
- 2009-06-23 AU AU2009271325A patent/AU2009271325A1/en not_active Abandoned
- 2009-06-23 JP JP2011516521A patent/JP2011525533A/ja active Pending
- 2009-06-23 KR KR1020117001584A patent/KR20110048509A/ko not_active Withdrawn
-
2011
- 2011-11-11 US US13/294,930 patent/US8859784B2/en active Active
-
2012
- 2012-03-30 US US13/436,506 patent/US8574876B2/en active Active
- 2012-05-07 US US13/465,735 patent/US20120289709A1/en not_active Abandoned
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2011525533A5 (https=) | ||
| JP2001515084A5 (https=) | ||
| JP2013518962A5 (https=) | ||
| JP2012515142A5 (https=) | ||
| RU2011133749A (ru) | Способ получения и выделения 2-ациламино-3-дифенилпропионовой кислоты | |
| NZ589497A (en) | Process for the synthesis of arformoterol | |
| CN111004277B (zh) | 一种新的草铵膦的制备方法 | |
| CA2549431A1 (en) | Optically active quaternary ammonium salt having axial asymmetry and process for producing .alpha.-amino acid and derivative thereof with the same | |
| JP2013020211A5 (https=) | ||
| EP2665705A4 (en) | PROCESS FOR THE IMPROVED PREPARATION OF SUCCINIMIDE COMPLEXES OF MOLYBDENUM OF LOW MOLECULAR WEIGHT | |
| JP2012532870A5 (https=) | ||
| CN1304097C (zh) | 一种双子型氟碳表面活性剂及其制备方法 | |
| RU2010147938A (ru) | Способ получения промежуточных соединений нафталин-2-ид-пиразол-3-она, используемых в синтезе ингибиторов сигма рецептора | |
| JP2007536395A5 (https=) | ||
| ATE441627T1 (de) | Verfahren zur herstellung von valsartan | |
| RU2008102884A (ru) | Диазепинохинолины, их синтез и промежуточные соединения | |
| JP2010512392A5 (https=) | ||
| RU2011126200A (ru) | Композиции и способы для смягчения тканей | |
| JP2012530834A5 (https=) | ||
| CN107011192B (zh) | 一种超长碳链双亲水头基疏水单体及其制备方法 | |
| CN101254431B (zh) | 十六酸酰胺表面活性剂及其合成方法 | |
| CN104610351A (zh) | 磷氮型天然气减阻剂及其合成方法 | |
| TW202210451A (zh) | 含氮螯合劑的製備 | |
| CN106380417B (zh) | 氨基酸酯溴化盐型手性离子液体及其制备方法 | |
| JP5929533B2 (ja) | ニトリル化合物の製造方法 |