KR20110048509A - 실질적으로 입체이성질체적으로 순수한 융합 이환식 프롤린 화합물의 제조를 위한 생체촉매 공정 - Google Patents
실질적으로 입체이성질체적으로 순수한 융합 이환식 프롤린 화합물의 제조를 위한 생체촉매 공정 Download PDFInfo
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- KR20110048509A KR20110048509A KR1020117001584A KR20117001584A KR20110048509A KR 20110048509 A KR20110048509 A KR 20110048509A KR 1020117001584 A KR1020117001584 A KR 1020117001584A KR 20117001584 A KR20117001584 A KR 20117001584A KR 20110048509 A KR20110048509 A KR 20110048509A
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- FGMPLJWBKKVCDB-UHFFFAOYSA-N trans-L-hydroxy-proline Natural products ON1CCCC1C(O)=O FGMPLJWBKKVCDB-UHFFFAOYSA-N 0.000 description 1
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- RZLVQBNCHSJZPX-UHFFFAOYSA-L zinc sulfate heptahydrate Chemical compound O.O.O.O.O.O.O.[Zn+2].[O-]S([O-])(=O)=O RZLVQBNCHSJZPX-UHFFFAOYSA-L 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/04—Alpha- or beta- amino acids
- C12P13/24—Proline; Hydroxyproline; Histidine
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/10—Nitrogen as only ring hetero atom
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
- C12P17/188—Heterocyclic compound containing in the condensed system at least one hetero ring having nitrogen atoms and oxygen atoms as the only ring heteroatoms
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y104/00—Oxidoreductases acting on the CH-NH2 group of donors (1.4)
- C12Y104/03—Oxidoreductases acting on the CH-NH2 group of donors (1.4) with oxygen as acceptor (1.4.3)
- C12Y104/03004—Monoamine oxidase (1.4.3.4)
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Microbiology (AREA)
- General Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Analytical Chemistry (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Peptides Or Proteins (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Indole Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US7524308P | 2008-06-24 | 2008-06-24 | |
| US61/075,243 | 2008-06-24 | ||
| PCT/US2009/048255 WO2010008828A2 (en) | 2008-06-24 | 2009-06-23 | Biocatalytic processes for the preparation of substantially stereomerically pure fused bicyclic proline compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR20110048509A true KR20110048509A (ko) | 2011-05-11 |
Family
ID=41550950
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020117001584A Withdrawn KR20110048509A (ko) | 2008-06-24 | 2009-06-23 | 실질적으로 입체이성질체적으로 순수한 융합 이환식 프롤린 화합물의 제조를 위한 생체촉매 공정 |
Country Status (10)
| Country | Link |
|---|---|
| US (4) | US8178333B2 (https=) |
| EP (2) | EP2481737A1 (https=) |
| JP (1) | JP2011525533A (https=) |
| KR (1) | KR20110048509A (https=) |
| CN (2) | CN102816106A (https=) |
| AU (1) | AU2009271325A1 (https=) |
| CA (1) | CA2728226A1 (https=) |
| ES (1) | ES2438576T3 (https=) |
| MX (1) | MX2010014500A (https=) |
| WO (1) | WO2010008828A2 (https=) |
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| KR20190129038A (ko) * | 2017-02-03 | 2019-11-19 | 앤티도트 테라퓨틱스 인코퍼레이티드 | 신규 니코틴 분해 효소 변형체 |
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| JP2013010732A (ja) | 2011-06-03 | 2013-01-17 | Sumitomo Chemical Co Ltd | プロリン化合物の製造方法 |
| CN103450066B (zh) * | 2012-05-30 | 2017-03-15 | 博瑞生物医药（苏州）股份有限公司 | 特拉匹韦中间体的制备方法 |
| AR091192A1 (es) | 2012-05-30 | 2015-01-21 | Chemo Iberica Sa | Procedimiento multicomponente para la preparacion de compuestos biciclicos |
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| ITMI20130706A1 (it) * | 2013-04-30 | 2014-10-31 | Dipharma Francis Srl | Procedimento per la preparazione di un inibitore delle proteasi virali e suoi intermedi |
| CN104292146B (zh) * | 2013-06-24 | 2017-04-26 | 上海医药工业研究院 | 特拉匹韦中间体及其制备方法 |
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| CN114317631B (zh) * | 2021-12-17 | 2023-11-07 | 武汉大学 | 单胺氧化酶在制备托品酮中的应用 |
| CN114292825B (zh) * | 2021-12-17 | 2023-08-18 | 武汉大学 | 一种托品酮的合成方法 |
| WO2023169071A1 (zh) * | 2022-03-10 | 2023-09-14 | 青岛清原化合物有限公司 | 单胺氧化酶及其应用 |
| US20230287361A1 (en) * | 2022-03-11 | 2023-09-14 | Codexis, Inc. | Engineered monoamine oxidases for the preparation of stereomerically pure fused bicyclic proline compounds |
| CN116891839A (zh) * | 2022-03-31 | 2023-10-17 | 青岛清原化合物有限公司 | 一种单胺氧化酶及其应用 |
| CN114774382A (zh) * | 2022-04-07 | 2022-07-22 | 扬州联澳生物医药有限公司 | 立体选择性制备6,6-二甲基-3-氮杂双环[3.1.0]己烯化合物的方法 |
| CN114751853B (zh) * | 2022-04-11 | 2023-10-13 | 扬州联澳生物医药有限公司 | 6,6-二甲基-3-氮杂双环[3.1.0]己烷化合物的制备方法 |
| CN114958938B (zh) * | 2022-05-13 | 2023-12-08 | 金达威生物技术(江苏)有限公司 | 一种稠合二环脯氨酸甲酯盐酸盐的制备方法 |
| CN114736882B (zh) * | 2022-05-20 | 2023-09-22 | 苏州百福安酶技术有限公司 | 一种单胺氧化酶及其应用 |
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- 2009-06-23 CA CA2728226A patent/CA2728226A1/en not_active Abandoned
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20190129038A (ko) * | 2017-02-03 | 2019-11-19 | 앤티도트 테라퓨틱스 인코퍼레이티드 | 신규 니코틴 분해 효소 변형체 |
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| US8859784B2 (en) | 2014-10-14 |
| US8574876B2 (en) | 2013-11-05 |
| ES2438576T3 (es) | 2014-01-17 |
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| EP2307419A4 (en) | 2012-07-04 |
| JP2011525533A (ja) | 2011-09-22 |
| CA2728226A1 (en) | 2010-01-21 |
| US8178333B2 (en) | 2012-05-15 |
| US20120130087A1 (en) | 2012-05-24 |
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| EP2307419B1 (en) | 2013-11-06 |
| US20120244581A1 (en) | 2012-09-27 |
| CN102131813B (zh) | 2014-07-30 |
| US20120289709A1 (en) | 2012-11-15 |
| CN102816106A (zh) | 2012-12-12 |
| AU2009271325A1 (en) | 2010-01-21 |
| WO2010008828A2 (en) | 2010-01-21 |
| EP2307419A2 (en) | 2011-04-13 |
| US20100063300A1 (en) | 2010-03-11 |
| MX2010014500A (es) | 2011-05-30 |
| WO2010008828A3 (en) | 2010-04-29 |
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