JP2011525533A - 実質的に立体異性的に純粋な縮合二環式プロリン化合物の調製のための生体触媒法 - Google Patents

実質的に立体異性的に純粋な縮合二環式プロリン化合物の調製のための生体触媒法 Download PDF

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JP2011525533A
JP2011525533A JP2011516521A JP2011516521A JP2011525533A JP 2011525533 A JP2011525533 A JP 2011525533A JP 2011516521 A JP2011516521 A JP 2011516521A JP 2011516521 A JP2011516521 A JP 2011516521A JP 2011525533 A JP2011525533 A JP 2011525533A
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compound
structural formula
monoamine oxidase
amino acid
seq
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JP2011525533A5 (https=
Inventor
ミツツ，ベンジヤミン
ミユーリー，シーラ
リアン，ジヤツク
ニユーマン，リサ・エム
ジヤン，シユイン
ラロンド，ジエームズ
クレイ，マイケル・デイー
ジユウ，ジユイン
グルーバー，ジヨン・エム
コールベツク，ジエフリー
マンガー，ジヨン・デイー，ジユニア
マビナハリ，ジヤグデイシユ
シエルドン，ロジヤー
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コデクシス， インコーポレイテッド
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/24—Proline; Hydroxyproline; Histidine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/10—Nitrogen as only ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/188—Heterocyclic compound containing in the condensed system at least one hetero ring having nitrogen atoms and oxygen atoms as the only ring heteroatoms
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y104/00—Oxidoreductases acting on the CH-NH2 group of donors (1.4)
    • C12Y104/03—Oxidoreductases acting on the CH-NH2 group of donors (1.4) with oxygen as acceptor (1.4.3)
    • C12Y104/03004—Monoamine oxidase (1.4.3.4)

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Indole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2011516521A 2008-06-24 2009-06-23 実質的に立体異性的に純粋な縮合二環式プロリン化合物の調製のための生体触媒法 Pending JP2011525533A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US7524308P 2008-06-24 2008-06-24
US61/075,243 2008-06-24
PCT/US2009/048255 WO2010008828A2 (en) 2008-06-24 2009-06-23 Biocatalytic processes for the preparation of substantially stereomerically pure fused bicyclic proline compounds

Publications (2)

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JP2011525533A true JP2011525533A (ja) 2011-09-22
JP2011525533A5 JP2011525533A5 (https=) 2012-07-26

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US (4) US8178333B2 (https=)
EP (2) EP2481737A1 (https=)
JP (1) JP2011525533A (https=)
KR (1) KR20110048509A (https=)
CN (2) CN102816106A (https=)
AU (1) AU2009271325A1 (https=)
CA (1) CA2728226A1 (https=)
ES (1) ES2438576T3 (https=)
MX (1) MX2010014500A (https=)
WO (1) WO2010008828A2 (https=)

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WO2011103933A1 (en) 2010-02-25 2011-09-01 Vereniging Voor Christelijk Hoger Onderwijs, Wetenschappelijk Onderzoek En Patiëntenzorg PROCESS FOR THE PREPARATION OF α-ACYLOXY β-FORMAMIDO AMIDES
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CN105624128B (zh) * 2014-11-26 2020-03-17 上海弈柯莱生物医药科技有限公司 一种固定化单胺氧化酶及其在合成手性氮杂双环化合物中的应用
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CN114317631B (zh) * 2021-12-17 2023-11-07 武汉大学 单胺氧化酶在制备托品酮中的应用
CN114292825B (zh) * 2021-12-17 2023-08-18 武汉大学 一种托品酮的合成方法
WO2023169071A1 (zh) * 2022-03-10 2023-09-14 青岛清原化合物有限公司 单胺氧化酶及其应用
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CN114774382A (zh) * 2022-04-07 2022-07-22 扬州联澳生物医药有限公司 立体选择性制备6,6-二甲基-3-氮杂双环[3.1.0]己烯化合物的方法
CN114751853B (zh) * 2022-04-11 2023-10-13 扬州联澳生物医药有限公司 6,6-二甲基-3-氮杂双环[3.1.0]己烷化合物的制备方法
CN114958938B (zh) * 2022-05-13 2023-12-08 金达威生物技术(江苏)有限公司 一种稠合二环脯氨酸甲酯盐酸盐的制备方法
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US8574876B2 (en) 2013-11-05
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CN102131813A (zh) 2011-07-20
EP2307419A4 (en) 2012-07-04
CA2728226A1 (en) 2010-01-21
US8178333B2 (en) 2012-05-15
US20120130087A1 (en) 2012-05-24
EP2481737A1 (en) 2012-08-01
EP2307419B1 (en) 2013-11-06
US20120244581A1 (en) 2012-09-27
CN102131813B (zh) 2014-07-30
KR20110048509A (ko) 2011-05-11
US20120289709A1 (en) 2012-11-15
CN102816106A (zh) 2012-12-12
AU2009271325A1 (en) 2010-01-21
WO2010008828A2 (en) 2010-01-21
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