JP2011525140A - 複合細胞外マトリックス材料およびそれらから形成される医療製品 - Google Patents
複合細胞外マトリックス材料およびそれらから形成される医療製品 Download PDFInfo
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/56—Porous materials, e.g. foams or sponges
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/3604—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
- A61L27/3633—Extracellular matrix [ECM]
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Animal Behavior & Ethology (AREA)
- Biomedical Technology (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Biophysics (AREA)
- Dispersion Chemistry (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- Zoology (AREA)
- Botany (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Materials For Medical Uses (AREA)
- Manufacture Of Porous Articles, And Recovery And Treatment Of Waste Products (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US7444108P | 2008-06-20 | 2008-06-20 | |
| US61/074,441 | 2008-06-20 | ||
| PCT/US2009/048168 WO2009155607A2 (en) | 2008-06-20 | 2009-06-22 | Composite extracellular matrix materials and medical products formed therefrom |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JP2011525140A true JP2011525140A (ja) | 2011-09-15 |
Family
ID=41117620
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011514890A Pending JP2011525140A (ja) | 2008-06-20 | 2009-06-22 | 複合細胞外マトリックス材料およびそれらから形成される医療製品 |
| JP2011514887A Pending JP2011525139A (ja) | 2008-06-20 | 2009-06-22 | 圧縮可能／拡張可能な医療用移植製品および止血方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011514887A Pending JP2011525139A (ja) | 2008-06-20 | 2009-06-22 | 圧縮可能／拡張可能な医療用移植製品および止血方法 |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US20090318934A1 (https=) |
| EP (2) | EP2358409B1 (https=) |
| JP (2) | JP2011525140A (https=) |
| CN (3) | CN104491928A (https=) |
| AU (2) | AU2009259835B2 (https=) |
| BR (2) | BRPI0914303A2 (https=) |
| CA (2) | CA2734560C (https=) |
| WO (2) | WO2009155600A2 (https=) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2015505693A (ja) * | 2011-12-09 | 2015-02-26 | アセル，インコーポレイテッド | 止血装置 |
| JP2016515407A (ja) * | 2013-03-15 | 2016-05-30 | クック・バイオテック・インコーポレイテッドＣｏｏｋ Ｂｉｏｔｅｃｈ Ｉｎｃｏｒｐｏｒａｔｅｄ | Ｅｃｍ移植組成物および方法 |
| JP2016521592A (ja) * | 2013-05-28 | 2016-07-25 | 北京博▲輝▼瑞▲進▼生物科技有限公司Ｂｅｉｊｉｎｇ Ｂｉｏｓｉｓ Ｈｅａｌｉｎｇ Ｂｉｏｌｏｇｉｃａｌ Ｔｅｃｈｎｏｌｏｇｙ Ｃｏ．， Ｌｔｄ． | 動物由来の植込み型医療用生体材料の調製方法 |
Families Citing this family (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9788821B2 (en) * | 2005-04-29 | 2017-10-17 | Cook Biotech Incorporated | Physically modified extracellular matrix materials and uses thereof |
| US20090318934A1 (en) * | 2008-06-20 | 2009-12-24 | Johnson Chad E | Compressible/expandable medical graft products, and methods for applying hemostasis |
| EP3744357A1 (en) | 2008-08-14 | 2020-12-02 | 3M Innovative Properties Company | Tissue scaffolds |
| US8652500B2 (en) * | 2009-07-22 | 2014-02-18 | Acell, Inc. | Particulate tissue graft with components of differing density and methods of making and using the same |
| US8518064B2 (en) * | 2009-12-17 | 2013-08-27 | Cook Medical Technologies Llc | Method for anchoring occlusion plug |
| US8329219B2 (en) | 2009-12-22 | 2012-12-11 | Cook Biotech Incorporated | Methods for producing ECM-based biomaterials |
| US9050067B2 (en) | 2011-09-26 | 2015-06-09 | Cook Medical Technologies, LLC | Percutaneous nephrostomy plug delivery device |
| EP2869861B1 (en) | 2012-07-05 | 2018-04-11 | Lifecell Corporation | Tissue-based drain manifolds |
| US9717583B2 (en) | 2014-03-13 | 2017-08-01 | Cell and Molecular Tissue Engineering, LLC | Sensors, cannulas, collars and coated surgical mesh, and corresponding systems and methods |
| US10405961B2 (en) | 2013-03-14 | 2019-09-10 | Cell and Molecular Tissue Engineering, LLC | Coated surgical mesh, and corresponding systems and methods |
| US10130288B2 (en) | 2013-03-14 | 2018-11-20 | Cell and Molecular Tissue Engineering, LLC | Coated sensors, and corresponding systems and methods |
| WO2014160060A1 (en) * | 2013-03-14 | 2014-10-02 | Cell and Molecular Tissue Engineering, LLC | Sensors, cannulas, collars and coated surgical mesh, and corresponding systems and methods |
| US9827271B2 (en) | 2013-03-15 | 2017-11-28 | Cook Biotech Incorporated | Methods and devices for lung volume reduction with extracellular matrix material |
| US20140271904A1 (en) * | 2013-03-15 | 2014-09-18 | Cryolife, Inc. | Methods for preparing tissue implants |
| EP2968120B1 (en) * | 2013-03-15 | 2026-01-14 | TARIS Biomedical LLC | Drug delivery devices and methods for drug delivery |
| ES2703785T3 (es) * | 2013-04-08 | 2019-03-12 | Regentys Corp | Método y composición para tratar una enfermedad inflamatoria intestinal sin colectomía |
| CN103272277B (zh) * | 2013-05-28 | 2015-04-08 | 北京博辉瑞进生物科技有限公司 | 用于制备脱细胞小肠粘膜下层基质材料的模具 |
| JP6475497B2 (ja) * | 2014-01-08 | 2019-02-27 | クック・バイオテック・インコーポレイテッドＣｏｏｋ Ｂｉｏｔｅｃｈ Ｉｎｃｏｒｐｏｒａｔｅｄ | 経皮的に設置された心臓弁に関連する弁周囲流を減少させるための装置 |
| US9610143B2 (en) | 2014-06-19 | 2017-04-04 | Osteolife Biomedical, Llc | Compressed decalcified trabecular bone grafts and tooth socket repair |
| US9775598B2 (en) | 2014-07-20 | 2017-10-03 | New York University | Anchored suture line, device and method for surgical suturing |
| US20160089477A1 (en) * | 2014-09-25 | 2016-03-31 | Acell, Inc. | Porous foams derived from extracellular matrix, porous foam ecm medical devices, and methods of use and making thereof |
| US9801983B2 (en) | 2014-12-18 | 2017-10-31 | Cook Medical Technologies Llc | Medical devices for delivering a bioactive to a point of treatment and methods of making medical devices |
| US9238090B1 (en) | 2014-12-24 | 2016-01-19 | Fettech, Llc | Tissue-based compositions |
| CN110975011B (zh) * | 2015-07-29 | 2022-06-14 | 广东博与再生医学有限公司 | 一种皮肤溃疡修复基质的制备方法 |
| US20170056164A1 (en) * | 2015-09-02 | 2017-03-02 | Medtronic Vascular, Inc. | Transcatheter valve prostheses having a sealing component formed from tissue having an altered extracellular matrix |
| US10549011B2 (en) | 2015-10-26 | 2020-02-04 | Osteolife Biomedical, Llc | Bone putty and gel systems and methods |
| US20170128633A1 (en) | 2015-11-10 | 2017-05-11 | Theodore Malinin | Bioactive Implants and Methods of Making and Using |
| CA3013296A1 (en) | 2016-02-11 | 2017-08-17 | Lifecell Corporation | Methods for stabilizing collagen-containing tissue products against enzymatic degradation |
| AU2017286715B2 (en) | 2016-06-15 | 2022-03-03 | The General Hospital Corporation | Metabolic labeling and molecular enhancement of biological materials using bioorthogonal reactions |
| US10639398B2 (en) * | 2016-07-05 | 2020-05-05 | Lifecell Corporation | Tissue matrices incorporating multiple tissue types |
| CN107007870B (zh) * | 2017-03-03 | 2019-11-19 | 北京博辉瑞进生物科技有限公司 | 一种生物止血材料、制备方法及其应用 |
| JP2020517399A (ja) * | 2017-04-28 | 2020-06-18 | クック・メディカル・テクノロジーズ・リミテッド・ライアビリティ・カンパニーＣｏｏｋ Ｍｅｄｉｃａｌ Ｔｅｃｈｎｏｌｏｇｉｅｓ Ｌｌｃ | 活動性出血を伴う消化管病変のバイモーダル治療方法及び組成物 |
| US11679177B2 (en) | 2017-08-08 | 2023-06-20 | Baxter International Inc. | Polymeric compositions, delivery devices, and methods |
| US11998654B2 (en) | 2018-07-12 | 2024-06-04 | Bard Shannon Limited | Securing implants and medical devices |
| CN109224132A (zh) * | 2018-09-17 | 2019-01-18 | 上海大学 | 多层复合腹壁修复补片支架及其制备方法 |
| CN111195173A (zh) * | 2018-11-19 | 2020-05-26 | 江苏昌吉永生物科技股份有限公司 | 一种注射型止血涂覆器及其制备方法 |
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| JP2022516562A (ja) * | 2019-01-07 | 2022-02-28 | ミロマトリックス メディカル インコーポレイテッド | 細胞外マトリクスの脱水方法およびそれにより形成される粒子 |
| CN110038163B (zh) * | 2019-04-16 | 2021-11-05 | 上海大学 | 一种用于修复腹壁缺损的水凝胶复合生物补片制备方法 |
| EP3976126A1 (en) | 2019-05-24 | 2022-04-06 | Cook Biotech Incorporated | Nasal septum cartilage compositions and methods |
| US11826490B1 (en) | 2020-12-29 | 2023-11-28 | Acell, Inc. | Extracellular matrix sheet devices with improved mechanical properties and method of making |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2002531181A (ja) * | 1998-12-01 | 2002-09-24 | クック・バイオテック・インコーポレーテッド | 多型コラーゲン性バイオマテリアル医療装置 |
| WO2006119256A2 (en) * | 2005-04-29 | 2006-11-09 | Cook Biotech Incorporated | Volumetric grafts for treatment of fistulae and related methods and systems |
| JP2007532153A (ja) * | 2004-03-31 | 2007-11-15 | クック インコーポレイテッド | Ｅｃｍを基材としたグラフト材料 |
| WO2008067085A2 (en) * | 2006-10-23 | 2008-06-05 | Cook Biotech Incorporated | Processed ecm materials with enhanced component profiles |
Family Cites Families (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB731501A (en) | 1952-08-08 | 1955-06-08 | Ethicon Suture Lab Inc | Preparation of collagenous material |
| FR1358465A (fr) * | 1963-02-21 | 1964-04-17 | Procédé de traitement de tissus animaux, en particulier en vue de la séparation de polysaccharides | |
| US3551560A (en) * | 1967-10-02 | 1970-12-29 | Heinrich F Thiele | Process of reconstructing tendons,cartilage,nerve sheaths,and products |
| FR2516927B1 (fr) * | 1981-11-26 | 1986-05-23 | Merieux Fond | Procede de preparation industrielle de materiaux collageniques a partir de tissus placentaires humains, materiaux collageniques humains obtenus, leur application comme biomateriaux |
| ATE109491T1 (de) * | 1988-03-11 | 1994-08-15 | Chemokol G B R Ing Buero Fuer | Verfahren zur herstellung von kollagenmembranen für hämostase, wundbehandlung und implantate. |
| US6350274B1 (en) * | 1992-05-11 | 2002-02-26 | Regen Biologics, Inc. | Soft tissue closure systems |
| US5523291A (en) * | 1993-09-07 | 1996-06-04 | Datascope Investment Corp. | Injectable compositions for soft tissue augmentation |
| AU700584C (en) * | 1994-08-12 | 2002-03-28 | Meadox Medicals, Inc. | Vascular graft impregnated with a heparin-containing collagen sealant |
| US5752974A (en) * | 1995-12-18 | 1998-05-19 | Collagen Corporation | Injectable or implantable biomaterials for filling or blocking lumens and voids of the body |
| US6666892B2 (en) * | 1996-08-23 | 2003-12-23 | Cook Biotech Incorporated | Multi-formed collagenous biomaterial medical device |
| US5993844A (en) * | 1997-05-08 | 1999-11-30 | Organogenesis, Inc. | Chemical treatment, without detergents or enzymes, of tissue to form an acellular, collagenous matrix |
| US6090996A (en) * | 1997-08-04 | 2000-07-18 | Collagen Matrix, Inc. | Implant matrix |
| DE69940507D1 (de) * | 1998-06-05 | 2009-04-16 | Organogenesis Inc | Biotechnisch erzeugte gefässprothese für die implantation |
| US8882850B2 (en) * | 1998-12-01 | 2014-11-11 | Cook Biotech Incorporated | Multi-formed collagenous biomaterial medical device |
| AU1801899A (en) | 1998-12-03 | 2000-06-19 | Histatek, Llc | Small peptides and methods for treatment of asthma and inflammation |
| US6376244B1 (en) * | 1999-12-29 | 2002-04-23 | Children's Medical Center Corporation | Methods and compositions for organ decellularization |
| US6471723B1 (en) * | 2000-01-10 | 2002-10-29 | St. Jude Medical, Inc. | Biocompatible prosthetic tissue |
| US6893462B2 (en) * | 2000-01-11 | 2005-05-17 | Regeneration Technologies, Inc. | Soft and calcified tissue implants |
| DE10025367A1 (de) * | 2000-05-23 | 2001-12-13 | Basf Ag | Frisch gefälltes CuO als Katalysator für die Trialkoxysilan-Synthese |
| MXPA03002414A (es) * | 2000-09-18 | 2004-07-08 | Organogenesis Inc | Protesis con injerto de hoja plana tratada por bioingenieria y su uso. |
| US6685626B2 (en) | 2001-02-02 | 2004-02-03 | Regeneration Technologies, Inc. | Compositions, devices, methods, and kits for induction of adhesions |
| EP1404390B1 (en) * | 2001-06-29 | 2012-08-01 | Cook Biotech, Inc. | Porous sponge matrix medical devices and methods |
| KR100947468B1 (ko) * | 2001-07-26 | 2010-03-17 | 쿠크 바이오텍, 인코포레이티드 | 혈관 폐쇄 부재 및 전달 장치 |
| US20050281999A1 (en) * | 2003-03-12 | 2005-12-22 | Petritech, Inc. | Structural and other composite materials and methods for making same |
| DE112004001553T5 (de) * | 2003-08-25 | 2006-08-10 | Cook Biotech, Inc., West Lafayette | Verpflanzungsmaterialien, die bioaktive Substanzen enthalten, und Methoden zu deren Herstellung |
| US20050117339A1 (en) * | 2003-12-01 | 2005-06-02 | Frank Pan | Illuminating light string arrangement |
| GB2449784B8 (en) * | 2004-02-09 | 2009-04-29 | Cook Biotech Inc | Stent graft devices having collagen coating. |
| US20080033550A1 (en) * | 2004-08-24 | 2008-02-07 | Gunze Limited | Process For Producing Collagen Sponge, Process For Producing Artificial Skin, Artificial Skin And Cell Tissue Culture Substrate |
| US9138445B2 (en) * | 2005-03-09 | 2015-09-22 | Cook Biotech Incorporated | Medical graft materials with adherent extracellular matrix fibrous mass |
| US9788821B2 (en) * | 2005-04-29 | 2017-10-17 | Cook Biotech Incorporated | Physically modified extracellular matrix materials and uses thereof |
| US9271817B2 (en) * | 2005-07-05 | 2016-03-01 | Cook Biotech Incorporated | Tissue augmentation devices and methods |
| US20070029247A1 (en) * | 2005-08-04 | 2007-02-08 | Compost And Technology Solutions, Inc. | Apparatus to separate waste from wastewater |
| US20090311298A1 (en) | 2005-10-18 | 2009-12-17 | Oranogenesis, In.C | Antimicrobial Collagenous Constructs |
| CA2871840A1 (en) * | 2006-02-10 | 2007-08-23 | Tengion, Inc. | Scaffolds for organ reconstruction and augmentation |
| US20090318934A1 (en) * | 2008-06-20 | 2009-12-24 | Johnson Chad E | Compressible/expandable medical graft products, and methods for applying hemostasis |
-
2009
- 2009-06-22 US US12/488,974 patent/US20090318934A1/en not_active Abandoned
- 2009-06-22 CN CN201410708559.XA patent/CN104491928A/zh active Pending
- 2009-06-22 EP EP09767907.0A patent/EP2358409B1/en not_active Not-in-force
- 2009-06-22 BR BRPI0914303A patent/BRPI0914303A2/pt active Search and Examination
- 2009-06-22 CN CN2009801299075A patent/CN102215883A/zh active Pending
- 2009-06-22 JP JP2011514890A patent/JP2011525140A/ja active Pending
- 2009-06-22 CN CN200980129908.XA patent/CN102112162B/zh not_active Expired - Fee Related
- 2009-06-22 AU AU2009259835A patent/AU2009259835B2/en not_active Ceased
- 2009-06-22 CA CA2734560A patent/CA2734560C/en not_active Expired - Fee Related
- 2009-06-22 JP JP2011514887A patent/JP2011525139A/ja active Pending
- 2009-06-22 BR BRPI0914304A patent/BRPI0914304A2/pt active Search and Examination
- 2009-06-22 US US12/488,996 patent/US8741354B2/en active Active
- 2009-06-22 EP EP09767914.6A patent/EP2307071B1/en not_active Not-in-force
- 2009-06-22 AU AU2009259828A patent/AU2009259828B2/en not_active Ceased
- 2009-06-22 CA CA2728513A patent/CA2728513C/en not_active Expired - Fee Related
- 2009-06-22 WO PCT/US2009/048152 patent/WO2009155600A2/en not_active Ceased
- 2009-06-22 WO PCT/US2009/048168 patent/WO2009155607A2/en not_active Ceased
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2002531181A (ja) * | 1998-12-01 | 2002-09-24 | クック・バイオテック・インコーポレーテッド | 多型コラーゲン性バイオマテリアル医療装置 |
| JP2007532153A (ja) * | 2004-03-31 | 2007-11-15 | クック インコーポレイテッド | Ｅｃｍを基材としたグラフト材料 |
| WO2006119256A2 (en) * | 2005-04-29 | 2006-11-09 | Cook Biotech Incorporated | Volumetric grafts for treatment of fistulae and related methods and systems |
| WO2008067085A2 (en) * | 2006-10-23 | 2008-06-05 | Cook Biotech Incorporated | Processed ecm materials with enhanced component profiles |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2015505693A (ja) * | 2011-12-09 | 2015-02-26 | アセル，インコーポレイテッド | 止血装置 |
| JP2016515407A (ja) * | 2013-03-15 | 2016-05-30 | クック・バイオテック・インコーポレイテッドＣｏｏｋ Ｂｉｏｔｅｃｈ Ｉｎｃｏｒｐｏｒａｔｅｄ | Ｅｃｍ移植組成物および方法 |
| US10973856B2 (en) | 2013-03-15 | 2021-04-13 | Cook Biotech Incorporated | ECM implant compositions and methods |
| JP2016521592A (ja) * | 2013-05-28 | 2016-07-25 | 北京博▲輝▼瑞▲進▼生物科技有限公司Ｂｅｉｊｉｎｇ Ｂｉｏｓｉｓ Ｈｅａｌｉｎｇ Ｂｉｏｌｏｇｉｃａｌ Ｔｅｃｈｎｏｌｏｇｙ Ｃｏ．， Ｌｔｄ． | 動物由来の植込み型医療用生体材料の調製方法 |
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| US20090318934A1 (en) | 2009-12-24 |
| WO2009155607A3 (en) | 2010-09-10 |
| CA2734560C (en) | 2018-10-23 |
| AU2009259828A1 (en) | 2009-12-23 |
| CA2728513A1 (en) | 2009-12-23 |
| JP2011525139A (ja) | 2011-09-15 |
| CN102112162A (zh) | 2011-06-29 |
| EP2358409A2 (en) | 2011-08-24 |
| US8741354B2 (en) | 2014-06-03 |
| BRPI0914303A2 (pt) | 2015-10-13 |
| BRPI0914304A2 (pt) | 2015-10-13 |
| CN102112162B (zh) | 2014-12-24 |
| CA2728513C (en) | 2016-03-15 |
| CN102215883A (zh) | 2011-10-12 |
| EP2307071B1 (en) | 2015-08-12 |
| AU2009259835A1 (en) | 2009-12-23 |
| EP2358409B1 (en) | 2017-01-18 |
| WO2009155600A2 (en) | 2009-12-23 |
| AU2009259835B2 (en) | 2014-02-20 |
| CA2734560A1 (en) | 2009-12-23 |
| EP2307071A2 (en) | 2011-04-13 |
| CN104491928A (zh) | 2015-04-08 |
| WO2009155607A2 (en) | 2009-12-23 |
| WO2009155600A3 (en) | 2010-09-30 |
| AU2009259828B2 (en) | 2014-05-08 |
| US20090317469A1 (en) | 2009-12-24 |
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