JP2011525140A - 複合細胞外マトリックス材料およびそれらから形成される医療製品 - Google Patents
複合細胞外マトリックス材料およびそれらから形成される医療製品 Download PDFInfo
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/56—Porous materials, e.g. foams or sponges
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/3604—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
- A61L27/3633—Extracellular matrix [ECM]
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Animal Behavior & Ethology (AREA)
- Biomedical Technology (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Biophysics (AREA)
- Dispersion Chemistry (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- Zoology (AREA)
- Botany (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Materials For Medical Uses (AREA)
- Manufacture Of Porous Articles, And Recovery And Treatment Of Waste Products (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US7444108P | 2008-06-20 | 2008-06-20 | |
| US61/074,441 | 2008-06-20 | ||
| PCT/US2009/048168 WO2009155607A2 (en) | 2008-06-20 | 2009-06-22 | Composite extracellular matrix materials and medical products formed therefrom |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JP2011525140A true JP2011525140A (ja) | 2011-09-15 |
Family
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Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011514890A Pending JP2011525140A (ja) | 2008-06-20 | 2009-06-22 | 複合細胞外マトリックス材料およびそれらから形成される医療製品 |
| JP2011514887A Pending JP2011525139A (ja) | 2008-06-20 | 2009-06-22 | 圧縮可能／拡張可能な医療用移植製品および止血方法 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011514887A Pending JP2011525139A (ja) | 2008-06-20 | 2009-06-22 | 圧縮可能／拡張可能な医療用移植製品および止血方法 |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US8741354B2 (enExample) |
| EP (2) | EP2307071B1 (enExample) |
| JP (2) | JP2011525140A (enExample) |
| CN (3) | CN104491928A (enExample) |
| AU (2) | AU2009259835B2 (enExample) |
| BR (2) | BRPI0914304A2 (enExample) |
| CA (2) | CA2728513C (enExample) |
| WO (2) | WO2009155607A2 (enExample) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2015505693A (ja) * | 2011-12-09 | 2015-02-26 | アセル，インコーポレイテッド | 止血装置 |
| JP2016515407A (ja) * | 2013-03-15 | 2016-05-30 | クック・バイオテック・インコーポレイテッドＣｏｏｋ Ｂｉｏｔｅｃｈ Ｉｎｃｏｒｐｏｒａｔｅｄ | Ｅｃｍ移植組成物および方法 |
| JP2016521592A (ja) * | 2013-05-28 | 2016-07-25 | 北京博▲輝▼瑞▲進▼生物科技有限公司Ｂｅｉｊｉｎｇ Ｂｉｏｓｉｓ Ｈｅａｌｉｎｇ Ｂｉｏｌｏｇｉｃａｌ Ｔｅｃｈｎｏｌｏｇｙ Ｃｏ．， Ｌｔｄ． | 動物由来の植込み型医療用生体材料の調製方法 |
Families Citing this family (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9788821B2 (en) * | 2005-04-29 | 2017-10-17 | Cook Biotech Incorporated | Physically modified extracellular matrix materials and uses thereof |
| US8741354B2 (en) * | 2008-06-20 | 2014-06-03 | Cook Biotech Incorporated | Composite extracellular matrix materials and medical products formed therefrom |
| US10413636B2 (en) | 2008-08-14 | 2019-09-17 | Kci Licensing, Inc. | Tissue scaffolds |
| US8652500B2 (en) | 2009-07-22 | 2014-02-18 | Acell, Inc. | Particulate tissue graft with components of differing density and methods of making and using the same |
| US8518064B2 (en) * | 2009-12-17 | 2013-08-27 | Cook Medical Technologies Llc | Method for anchoring occlusion plug |
| US8329219B2 (en) | 2009-12-22 | 2012-12-11 | Cook Biotech Incorporated | Methods for producing ECM-based biomaterials |
| US9050067B2 (en) | 2011-09-26 | 2015-06-09 | Cook Medical Technologies, LLC | Percutaneous nephrostomy plug delivery device |
| US10363343B2 (en) | 2012-07-05 | 2019-07-30 | Lifecell Corporation | Tissue-based drain manifolds |
| WO2014160060A1 (en) * | 2013-03-14 | 2014-10-02 | Cell and Molecular Tissue Engineering, LLC | Sensors, cannulas, collars and coated surgical mesh, and corresponding systems and methods |
| US10130288B2 (en) | 2013-03-14 | 2018-11-20 | Cell and Molecular Tissue Engineering, LLC | Coated sensors, and corresponding systems and methods |
| US9717583B2 (en) | 2014-03-13 | 2017-08-01 | Cell and Molecular Tissue Engineering, LLC | Sensors, cannulas, collars and coated surgical mesh, and corresponding systems and methods |
| US10405961B2 (en) | 2013-03-14 | 2019-09-10 | Cell and Molecular Tissue Engineering, LLC | Coated surgical mesh, and corresponding systems and methods |
| WO2014149953A1 (en) * | 2013-03-15 | 2014-09-25 | Cryolife, Inc. | Methods for preparing tissue implants |
| AU2014227914B2 (en) * | 2013-03-15 | 2018-05-10 | Taris Biomedical Llc | Drug delivery devices and methods for drug delivery |
| WO2014144294A1 (en) * | 2013-03-15 | 2014-09-18 | Cook Biotech Incorporated | Methods and devices for lung volume reduction with extracellular matrix material |
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| CN103272277B (zh) * | 2013-05-28 | 2015-04-08 | 北京博辉瑞进生物科技有限公司 | 用于制备脱细胞小肠粘膜下层基质材料的模具 |
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2002531181A (ja) * | 1998-12-01 | 2002-09-24 | クック・バイオテック・インコーポレーテッド | 多型コラーゲン性バイオマテリアル医療装置 |
| WO2006119256A2 (en) * | 2005-04-29 | 2006-11-09 | Cook Biotech Incorporated | Volumetric grafts for treatment of fistulae and related methods and systems |
| JP2007532153A (ja) * | 2004-03-31 | 2007-11-15 | クック インコーポレイテッド | Ｅｃｍを基材としたグラフト材料 |
| WO2008067085A2 (en) * | 2006-10-23 | 2008-06-05 | Cook Biotech Incorporated | Processed ecm materials with enhanced component profiles |
Family Cites Families (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB731501A (en) | 1952-08-08 | 1955-06-08 | Ethicon Suture Lab Inc | Preparation of collagenous material |
| FR1358465A (fr) * | 1963-02-21 | 1964-04-17 | Procédé de traitement de tissus animaux, en particulier en vue de la séparation de polysaccharides | |
| US3551560A (en) | 1967-10-02 | 1970-12-29 | Heinrich F Thiele | Process of reconstructing tendons,cartilage,nerve sheaths,and products |
| FR2516927B1 (fr) * | 1981-11-26 | 1986-05-23 | Merieux Fond | Procede de preparation industrielle de materiaux collageniques a partir de tissus placentaires humains, materiaux collageniques humains obtenus, leur application comme biomateriaux |
| ATE109491T1 (de) * | 1988-03-11 | 1994-08-15 | Chemokol G B R Ing Buero Fuer | Verfahren zur herstellung von kollagenmembranen für hämostase, wundbehandlung und implantate. |
| US6350274B1 (en) * | 1992-05-11 | 2002-02-26 | Regen Biologics, Inc. | Soft tissue closure systems |
| US5523291A (en) * | 1993-09-07 | 1996-06-04 | Datascope Investment Corp. | Injectable compositions for soft tissue augmentation |
| AU700584C (en) * | 1994-08-12 | 2002-03-28 | Meadox Medicals, Inc. | Vascular graft impregnated with a heparin-containing collagen sealant |
| US5752974A (en) | 1995-12-18 | 1998-05-19 | Collagen Corporation | Injectable or implantable biomaterials for filling or blocking lumens and voids of the body |
| US6666892B2 (en) | 1996-08-23 | 2003-12-23 | Cook Biotech Incorporated | Multi-formed collagenous biomaterial medical device |
| US5993844A (en) * | 1997-05-08 | 1999-11-30 | Organogenesis, Inc. | Chemical treatment, without detergents or enzymes, of tissue to form an acellular, collagenous matrix |
| US6090996A (en) | 1997-08-04 | 2000-07-18 | Collagen Matrix, Inc. | Implant matrix |
| CA2334435C (en) | 1998-06-05 | 2010-10-05 | Organogenesis Inc. | Bioengineered vascular graft prostheses |
| US8882850B2 (en) * | 1998-12-01 | 2014-11-11 | Cook Biotech Incorporated | Multi-formed collagenous biomaterial medical device |
| AU1801899A (en) | 1998-12-03 | 2000-06-19 | Histatek, Llc | Small peptides and methods for treatment of asthma and inflammation |
| US6376244B1 (en) | 1999-12-29 | 2002-04-23 | Children's Medical Center Corporation | Methods and compositions for organ decellularization |
| US6471723B1 (en) | 2000-01-10 | 2002-10-29 | St. Jude Medical, Inc. | Biocompatible prosthetic tissue |
| US6893462B2 (en) * | 2000-01-11 | 2005-05-17 | Regeneration Technologies, Inc. | Soft and calcified tissue implants |
| DE10025367A1 (de) * | 2000-05-23 | 2001-12-13 | Basf Ag | Frisch gefälltes CuO als Katalysator für die Trialkoxysilan-Synthese |
| CA2777791A1 (en) * | 2000-09-18 | 2002-03-21 | Organogenesis Inc. | Methods for treating a patient using a bioengineered flat sheet graft prostheses |
| US6685626B2 (en) * | 2001-02-02 | 2004-02-03 | Regeneration Technologies, Inc. | Compositions, devices, methods, and kits for induction of adhesions |
| AU2002320182B2 (en) * | 2001-06-29 | 2008-02-21 | Cook Biotech Incorporated | Porous sponge matrix medical devices and methods |
| ATE294535T1 (de) | 2001-07-26 | 2005-05-15 | Univ Oregon Health Sciences | Verschlusseinrichtung für ein gefäss und anbringungsvorrichtung |
| US20050281999A1 (en) * | 2003-03-12 | 2005-12-22 | Petritech, Inc. | Structural and other composite materials and methods for making same |
| US8021692B2 (en) * | 2003-08-25 | 2011-09-20 | Cook Biotech Incorporated | Graft materials containing bioactive substances, and methods for their manufacture |
| US20050117339A1 (en) | 2003-12-01 | 2005-06-02 | Frank Pan | Illuminating light string arrangement |
| GB2449784B8 (en) * | 2004-02-09 | 2009-04-29 | Cook Biotech Inc | Stent graft devices having collagen coating. |
| EP1787664A4 (en) * | 2004-08-24 | 2011-08-24 | Gunze Kk | METHOD FOR PRODUCING COLLAGEN SPONGE, METHOD FOR PRODUCING ARTIFICIAL SKIN, ARTIFICIAL SKIN, AND CELL TISSUE CULTURE SUBSTRATE |
| US9138445B2 (en) * | 2005-03-09 | 2015-09-22 | Cook Biotech Incorporated | Medical graft materials with adherent extracellular matrix fibrous mass |
| US9788821B2 (en) * | 2005-04-29 | 2017-10-17 | Cook Biotech Incorporated | Physically modified extracellular matrix materials and uses thereof |
| US9271817B2 (en) * | 2005-07-05 | 2016-03-01 | Cook Biotech Incorporated | Tissue augmentation devices and methods |
| US20070029247A1 (en) * | 2005-08-04 | 2007-02-08 | Compost And Technology Solutions, Inc. | Apparatus to separate waste from wastewater |
| JP5208752B2 (ja) | 2005-10-18 | 2013-06-12 | オーガノジェネシス・インコーポレイテッド | 抗菌性コラーゲン構築物 |
| EP1987134A4 (en) * | 2006-02-10 | 2012-08-01 | Tengion Inc | EQUIPMENT FOR ORGANIC DESIGN AND AUGMENTATION |
| US8741354B2 (en) * | 2008-06-20 | 2014-06-03 | Cook Biotech Incorporated | Composite extracellular matrix materials and medical products formed therefrom |
-
2009
- 2009-06-22 US US12/488,996 patent/US8741354B2/en active Active
- 2009-06-22 JP JP2011514890A patent/JP2011525140A/ja active Pending
- 2009-06-22 CA CA2728513A patent/CA2728513C/en not_active Expired - Fee Related
- 2009-06-22 CN CN201410708559.XA patent/CN104491928A/zh active Pending
- 2009-06-22 BR BRPI0914304A patent/BRPI0914304A2/pt active Search and Examination
- 2009-06-22 JP JP2011514887A patent/JP2011525139A/ja active Pending
- 2009-06-22 AU AU2009259835A patent/AU2009259835B2/en not_active Ceased
- 2009-06-22 BR BRPI0914303A patent/BRPI0914303A2/pt active Search and Examination
- 2009-06-22 EP EP09767914.6A patent/EP2307071B1/en not_active Not-in-force
- 2009-06-22 CN CN2009801299075A patent/CN102215883A/zh active Pending
- 2009-06-22 WO PCT/US2009/048168 patent/WO2009155607A2/en not_active Ceased
- 2009-06-22 AU AU2009259828A patent/AU2009259828B2/en not_active Ceased
- 2009-06-22 CN CN200980129908.XA patent/CN102112162B/zh not_active Expired - Fee Related
- 2009-06-22 WO PCT/US2009/048152 patent/WO2009155600A2/en not_active Ceased
- 2009-06-22 US US12/488,974 patent/US20090318934A1/en not_active Abandoned
- 2009-06-22 EP EP09767907.0A patent/EP2358409B1/en not_active Not-in-force
- 2009-06-22 CA CA2734560A patent/CA2734560C/en not_active Expired - Fee Related
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2002531181A (ja) * | 1998-12-01 | 2002-09-24 | クック・バイオテック・インコーポレーテッド | 多型コラーゲン性バイオマテリアル医療装置 |
| JP2007532153A (ja) * | 2004-03-31 | 2007-11-15 | クック インコーポレイテッド | Ｅｃｍを基材としたグラフト材料 |
| WO2006119256A2 (en) * | 2005-04-29 | 2006-11-09 | Cook Biotech Incorporated | Volumetric grafts for treatment of fistulae and related methods and systems |
| WO2008067085A2 (en) * | 2006-10-23 | 2008-06-05 | Cook Biotech Incorporated | Processed ecm materials with enhanced component profiles |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2015505693A (ja) * | 2011-12-09 | 2015-02-26 | アセル，インコーポレイテッド | 止血装置 |
| JP2016515407A (ja) * | 2013-03-15 | 2016-05-30 | クック・バイオテック・インコーポレイテッドＣｏｏｋ Ｂｉｏｔｅｃｈ Ｉｎｃｏｒｐｏｒａｔｅｄ | Ｅｃｍ移植組成物および方法 |
| US10973856B2 (en) | 2013-03-15 | 2021-04-13 | Cook Biotech Incorporated | ECM implant compositions and methods |
| JP2016521592A (ja) * | 2013-05-28 | 2016-07-25 | 北京博▲輝▼瑞▲進▼生物科技有限公司Ｂｅｉｊｉｎｇ Ｂｉｏｓｉｓ Ｈｅａｌｉｎｇ Ｂｉｏｌｏｇｉｃａｌ Ｔｅｃｈｎｏｌｏｇｙ Ｃｏ．， Ｌｔｄ． | 動物由来の植込み型医療用生体材料の調製方法 |
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| CA2728513C (en) | 2016-03-15 |
| AU2009259828A1 (en) | 2009-12-23 |
| CA2734560A1 (en) | 2009-12-23 |
| US20090317469A1 (en) | 2009-12-24 |
| WO2009155607A2 (en) | 2009-12-23 |
| WO2009155600A3 (en) | 2010-09-30 |
| WO2009155607A3 (en) | 2010-09-10 |
| CN102112162B (zh) | 2014-12-24 |
| CA2734560C (en) | 2018-10-23 |
| CN104491928A (zh) | 2015-04-08 |
| WO2009155600A2 (en) | 2009-12-23 |
| CA2728513A1 (en) | 2009-12-23 |
| AU2009259835B2 (en) | 2014-02-20 |
| CN102215883A (zh) | 2011-10-12 |
| BRPI0914304A2 (pt) | 2015-10-13 |
| US20090318934A1 (en) | 2009-12-24 |
| EP2307071B1 (en) | 2015-08-12 |
| JP2011525139A (ja) | 2011-09-15 |
| EP2358409B1 (en) | 2017-01-18 |
| US8741354B2 (en) | 2014-06-03 |
| AU2009259828B2 (en) | 2014-05-08 |
| CN102112162A (zh) | 2011-06-29 |
| AU2009259835A1 (en) | 2009-12-23 |
| EP2358409A2 (en) | 2011-08-24 |
| EP2307071A2 (en) | 2011-04-13 |
| BRPI0914303A2 (pt) | 2015-10-13 |
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