JP2011523351A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2011523351A5 JP2011523351A5 JP2011506301A JP2011506301A JP2011523351A5 JP 2011523351 A5 JP2011523351 A5 JP 2011523351A5 JP 2011506301 A JP2011506301 A JP 2011506301A JP 2011506301 A JP2011506301 A JP 2011506301A JP 2011523351 A5 JP2011523351 A5 JP 2011523351A5
- Authority
- JP
- Japan
- Prior art keywords
- variable domain
- antibody
- domain sequence
- fcrn
- fragment
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 102100026120 IgG receptor FcRn large subunit p51 Human genes 0.000 claims 8
- 101710177940 IgG receptor FcRn large subunit p51 Proteins 0.000 claims 8
- 239000012634 fragment Substances 0.000 claims 8
- 108060003951 Immunoglobulin Proteins 0.000 claims 7
- 102000018358 immunoglobulin Human genes 0.000 claims 7
- 108010068617 neonatal Fc receptor Proteins 0.000 claims 7
- 101710117290 Aldo-keto reductase family 1 member C4 Proteins 0.000 claims 5
- 208000023275 Autoimmune disease Diseases 0.000 claims 3
- 230000000694 effects Effects 0.000 claims 3
- 206010021245 Idiopathic thrombocytopenic purpura Diseases 0.000 claims 2
- 208000031981 Thrombocytopenic Idiopathic Purpura Diseases 0.000 claims 2
- 206010067584 Type 1 diabetes mellitus Diseases 0.000 claims 2
- 201000003710 autoimmune thrombocytopenic purpura Diseases 0.000 claims 2
- 102000015736 beta 2-Microglobulin Human genes 0.000 claims 2
- 108010081355 beta 2-Microglobulin Proteins 0.000 claims 2
- 239000003112 inhibitor Substances 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 206010028417 myasthenia gravis Diseases 0.000 claims 2
- 230000036963 noncompetitive effect Effects 0.000 claims 2
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 2
- 201000000596 systemic lupus erythematosus Diseases 0.000 claims 2
- 208000003343 Antiphospholipid Syndrome Diseases 0.000 claims 1
- 208000032116 Autoimmune Experimental Encephalomyelitis Diseases 0.000 claims 1
- 206010064539 Autoimmune myocarditis Diseases 0.000 claims 1
- 208000023328 Basedow disease Diseases 0.000 claims 1
- 208000008439 Biliary Liver Cirrhosis Diseases 0.000 claims 1
- 208000033222 Biliary cirrhosis primary Diseases 0.000 claims 1
- 208000015943 Coeliac disease Diseases 0.000 claims 1
- 206010011686 Cutaneous vasculitis Diseases 0.000 claims 1
- 102000004127 Cytokines Human genes 0.000 claims 1
- 108090000695 Cytokines Proteins 0.000 claims 1
- 208000007882 Gastritis Diseases 0.000 claims 1
- 208000024869 Goodpasture syndrome Diseases 0.000 claims 1
- 208000015023 Graves' disease Diseases 0.000 claims 1
- 208000035895 Guillain-Barré syndrome Diseases 0.000 claims 1
- 208000030836 Hashimoto thyroiditis Diseases 0.000 claims 1
- 101000690301 Homo sapiens Aldo-keto reductase family 1 member C4 Proteins 0.000 claims 1
- 101001116548 Homo sapiens Protein CBFA2T1 Proteins 0.000 claims 1
- 208000022559 Inflammatory bowel disease Diseases 0.000 claims 1
- 208000011200 Kawasaki disease Diseases 0.000 claims 1
- 206010049567 Miller Fisher syndrome Diseases 0.000 claims 1
- 206010034277 Pemphigoid Diseases 0.000 claims 1
- 241000721454 Pemphigus Species 0.000 claims 1
- 208000012654 Primary biliary cholangitis Diseases 0.000 claims 1
- 208000003782 Raynaud disease Diseases 0.000 claims 1
- 208000012322 Raynaud phenomenon Diseases 0.000 claims 1
- 208000021386 Sjogren Syndrome Diseases 0.000 claims 1
- 208000006045 Spondylarthropathies Diseases 0.000 claims 1
- 201000009594 Systemic Scleroderma Diseases 0.000 claims 1
- 206010042953 Systemic sclerosis Diseases 0.000 claims 1
- 210000001744 T-lymphocyte Anatomy 0.000 claims 1
- 206010053613 Type IV hypersensitivity reaction Diseases 0.000 claims 1
- 206010047642 Vitiligo Diseases 0.000 claims 1
- 239000000427 antigen Substances 0.000 claims 1
- 102000036639 antigens Human genes 0.000 claims 1
- 108091007433 antigens Proteins 0.000 claims 1
- 206010012601 diabetes mellitus Diseases 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 208000012997 experimental autoimmune encephalomyelitis Diseases 0.000 claims 1
- 208000006454 hepatitis Diseases 0.000 claims 1
- 231100000283 hepatitis Toxicity 0.000 claims 1
- 102000054751 human RUNX1T1 Human genes 0.000 claims 1
- 230000028993 immune response Effects 0.000 claims 1
- 230000001404 mediated effect Effects 0.000 claims 1
- 201000008350 membranous glomerulonephritis Diseases 0.000 claims 1
- 208000001725 mucocutaneous lymph node syndrome Diseases 0.000 claims 1
- 201000006417 multiple sclerosis Diseases 0.000 claims 1
- 229960005027 natalizumab Drugs 0.000 claims 1
- 208000004235 neutropenia Diseases 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 208000005987 polymyositis Diseases 0.000 claims 1
- 201000000306 sarcoidosis Diseases 0.000 claims 1
- 201000005671 spondyloarthropathy Diseases 0.000 claims 1
- 208000024891 symptom Diseases 0.000 claims 1
- 201000008827 tuberculosis Diseases 0.000 claims 1
- 208000001072 type 2 diabetes mellitus Diseases 0.000 claims 1
- 230000005951 type IV hypersensitivity Effects 0.000 claims 1
- 208000027930 type IV hypersensitivity disease Diseases 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US4815208P | 2008-04-25 | 2008-04-25 | |
| US61/048,152 | 2008-04-25 | ||
| US4850008P | 2008-04-28 | 2008-04-28 | |
| US61/048,500 | 2008-04-28 | ||
| PCT/US2009/002536 WO2009131702A2 (en) | 2008-04-25 | 2009-04-24 | Antibodies against fcrn and use thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015027638A Division JP5989159B2 (ja) | 2008-04-25 | 2015-02-16 | ＦｃＲｎに対する抗体及びその使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011523351A JP2011523351A (ja) | 2011-08-11 |
| JP2011523351A5 true JP2011523351A5 (cg-RX-API-DMAC7.html) | 2012-06-07 |
| JP6106854B2 JP6106854B2 (ja) | 2017-04-05 |
Family
ID=41203902
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011506301A Active JP6106854B2 (ja) | 2008-04-25 | 2009-04-24 | ＦｃＲｎに対する抗体及びその使用 |
| JP2015027638A Active JP5989159B2 (ja) | 2008-04-25 | 2015-02-16 | ＦｃＲｎに対する抗体及びその使用 |
| JP2016155218A Active JP6499132B2 (ja) | 2008-04-25 | 2016-08-08 | ＦｃＲｎに対する抗体及びその使用 |
| JP2019046955A Pending JP2019162105A (ja) | 2008-04-25 | 2019-03-14 | ＦｃＲｎに対する抗体及びその使用 |
| JP2022075914A Pending JP2022115960A (ja) | 2008-04-25 | 2022-05-02 | ＦｃＲｎに対する抗体及びその使用 |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015027638A Active JP5989159B2 (ja) | 2008-04-25 | 2015-02-16 | ＦｃＲｎに対する抗体及びその使用 |
| JP2016155218A Active JP6499132B2 (ja) | 2008-04-25 | 2016-08-08 | ＦｃＲｎに対する抗体及びその使用 |
| JP2019046955A Pending JP2019162105A (ja) | 2008-04-25 | 2019-03-14 | ＦｃＲｎに対する抗体及びその使用 |
| JP2022075914A Pending JP2022115960A (ja) | 2008-04-25 | 2022-05-02 | ＦｃＲｎに対する抗体及びその使用 |
Country Status (17)
| Country | Link |
|---|---|
| US (10) | US8273351B2 (cg-RX-API-DMAC7.html) |
| EP (3) | EP3348573B1 (cg-RX-API-DMAC7.html) |
| JP (5) | JP6106854B2 (cg-RX-API-DMAC7.html) |
| KR (4) | KR101837329B1 (cg-RX-API-DMAC7.html) |
| CN (3) | CN104479017A (cg-RX-API-DMAC7.html) |
| AU (1) | AU2009238605B2 (cg-RX-API-DMAC7.html) |
| BR (2) | BR122021026834B1 (cg-RX-API-DMAC7.html) |
| CA (2) | CA2722082C (cg-RX-API-DMAC7.html) |
| ES (1) | ES2650804T3 (cg-RX-API-DMAC7.html) |
| HK (1) | HK1207089A1 (cg-RX-API-DMAC7.html) |
| IL (2) | IL208846A (cg-RX-API-DMAC7.html) |
| MX (1) | MX2010011679A (cg-RX-API-DMAC7.html) |
| NZ (1) | NZ589451A (cg-RX-API-DMAC7.html) |
| SG (3) | SG10202105499WA (cg-RX-API-DMAC7.html) |
| TW (3) | TWI593423B (cg-RX-API-DMAC7.html) |
| WO (1) | WO2009131702A2 (cg-RX-API-DMAC7.html) |
| ZA (1) | ZA201007873B (cg-RX-API-DMAC7.html) |
Families Citing this family (58)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2722082C (en) * | 2008-04-25 | 2021-11-09 | Christopher Tenhoor | Fc receptor binding proteins |
| EP2679681B2 (en) | 2011-02-25 | 2023-11-15 | Chugai Seiyaku Kabushiki Kaisha | FcgammaRIIB-specific FC antibody |
| PH12013502378A1 (en) | 2011-06-02 | 2014-01-06 | Dyax Corp | Fc RECEPTOR BINDING PROTEINS |
| EP2728002B1 (en) | 2011-06-30 | 2022-01-19 | Chugai Seiyaku Kabushiki Kaisha | Heterodimerized polypeptide |
| JP6322411B2 (ja) | 2011-09-30 | 2018-05-09 | 中外製薬株式会社 | 複数の生理活性を有する抗原の消失を促進する抗原結合分子 |
| KR102528622B1 (ko) * | 2011-09-30 | 2023-05-04 | 추가이 세이야쿠 가부시키가이샤 | 이온 농도 의존성 결합 분자 라이브러리 |
| KR20230143201A (ko) | 2011-11-30 | 2023-10-11 | 추가이 세이야쿠 가부시키가이샤 | 면역 복합체를 형성하는 세포내로의 운반체（캐리어）를 포함하는 의약 |
| TWI682939B (zh) * | 2012-02-24 | 2020-01-21 | 日商中外製藥股份有限公司 | 經ＦｃγＲＩＩＢ促進抗原消失之抗原結合分子 |
| US9809641B2 (en) | 2012-04-23 | 2017-11-07 | Nrl Pharma, Inc. | Lactoferrin fusion protein and method for preparation thereof |
| GB201208370D0 (en) | 2012-05-14 | 2012-06-27 | Ucb Pharma Sa | Antibodies |
| SG11201504822VA (en) * | 2012-12-21 | 2015-07-30 | Biogen Idec Internat Neuroscience Gmbh | Human anti-tau antibodies |
| KR102191654B1 (ko) * | 2013-03-15 | 2020-12-16 | 애피바디 에이비 | 신규 폴리펩티드 |
| ZA201506407B (en) * | 2013-03-15 | 2018-11-28 | Affibody Ab | New polypeptides |
| US11267868B2 (en) | 2013-04-02 | 2022-03-08 | Chugai Seiyaku Kabushiki Kaisha | Fc region variant |
| US20160075766A1 (en) * | 2013-05-21 | 2016-03-17 | Roche Diagnostics Operations, Inc. | Method for producing antibodies using ovine b-cells and uses thereof |
| BR112016004242A8 (pt) * | 2013-08-28 | 2018-06-12 | Stemcentrx Inc | Métodos para conjugação sítio-específica de anticorpos e composições |
| GB201320066D0 (en) * | 2013-11-13 | 2013-12-25 | Ucb Pharma Sa | Biological products |
| DK3087095T3 (da) * | 2013-12-24 | 2019-10-28 | Argenx Bvba | FcRn-antagonist og fremgangsmåder til anvendelse |
| CA2983796A1 (en) * | 2014-04-25 | 2015-10-29 | The Brigham And Women's Hospital, Inc. | Compositions and methods for treating subjects with immune-mediated diseases |
| US10336825B2 (en) | 2014-04-30 | 2019-07-02 | Hanall Biopharma Co., Ltd. | Antibody binding to FcRn for treating autoimmune diseases |
| PT3137504T (pt) * | 2014-04-30 | 2023-08-18 | Hanall Biopharma Co Ltd | Anticorpo que se liga a fcrn para tratar doenças autoimunes |
| CA2914595C (en) * | 2014-05-19 | 2022-12-13 | F. Hoffmann-La Roche Ag | Method for producing antibodies using ovine b-cells and uses thereof |
| ES2744588T3 (es) | 2014-09-17 | 2020-02-25 | Affibody Ab | Nuevos polipéptidos |
| AR103161A1 (es) | 2014-12-19 | 2017-04-19 | Chugai Pharmaceutical Co Ltd | Anticuerpos antimiostatina y regiones fc variantes así como métodos de uso |
| SG11201705475QA (en) * | 2015-01-30 | 2017-08-30 | Momenta Pharmaceuticals Inc | Fcrn antibodies and methods of use thereof |
| TW202248212A (zh) | 2015-02-05 | 2022-12-16 | 日商中外製藥股份有限公司 | 包含離子濃度依賴之抗原結合域的抗體、Fc區變體、IL-8結合抗體與其用途 |
| EP3294335B1 (en) * | 2015-05-12 | 2023-07-05 | Syntimmune Inc. | Humanized affinity matured anti-fcrn antibodies |
| GB201508180D0 (en) * | 2015-05-13 | 2015-06-24 | Ucb Biopharma Sprl | Antibodies |
| EP3341738A4 (en) | 2015-08-24 | 2019-02-27 | University of Cincinnati | METHOD AND COMPOSITIONS FOR DETECTING FC RECEPTOR BINDING ACTIVITY OF ANTIBODIES |
| EP3394098A4 (en) | 2015-12-25 | 2019-11-13 | Chugai Seiyaku Kabushiki Kaisha | ANTI-MYOSTATIN ANTIBODIES AND METHODS OF USE |
| CN106957365B (zh) * | 2016-01-11 | 2021-03-16 | 上海交通大学 | 一种单克隆抗体FnAb8及其应用 |
| US11542332B2 (en) | 2016-03-26 | 2023-01-03 | Bioatla, Inc. | Anti-CTLA4 antibodies, antibody fragments, their immunoconjugates and uses thereof |
| IL302288B2 (en) * | 2016-07-29 | 2025-09-01 | Momenta Pharmaceuticals Inc | FCRN antibodies and methods of using them |
| EP3494991A4 (en) | 2016-08-05 | 2020-07-29 | Chugai Seiyaku Kabushiki Kaisha | COMPOSITION FOR THE PROPHYLAXIS OR TREATMENT OF IL-8 RELATED DISEASES |
| EP3533870A4 (en) | 2016-10-28 | 2020-04-08 | NRL Pharma, Inc. | LACTOFERRIN / ALBUMIN FUSION PROTEIN AND PROCESS FOR PRODUCING THE SAME |
| GB201618424D0 (en) * | 2016-11-01 | 2016-12-14 | Argenix Bvba | Treatment of antibody mediated disease |
| BR112019026694A2 (pt) * | 2017-06-15 | 2020-06-23 | UCB Biopharma SRL | Método para o tratamento da trombocitopenia imune |
| JP7731196B2 (ja) | 2017-11-14 | 2025-08-29 | 中外製薬株式会社 | 抗Ｃ１ｓ抗体および使用方法 |
| AU2018380979B2 (en) | 2017-12-08 | 2023-07-20 | argenx BV | Use of FcRn antagonists for treatment of generalized myasthenia gravis |
| BR112020011310A2 (pt) * | 2017-12-13 | 2020-11-17 | Momenta Pharmaceuticals, Inc. | anticorpos contra fcrn e seus métodos de uso |
| MX2020013195A (es) | 2018-06-08 | 2021-02-26 | Argenx Bvba | Composiciones y metodos para el tratamiento de la trombocitopenia inmunitaria. |
| BR112021000755A2 (pt) * | 2018-07-20 | 2021-04-13 | Momenta Pharmaceuticals, Inc. | Composições de anticorpo de fcrn |
| CN118754986A (zh) | 2018-08-10 | 2024-10-11 | 中外制药株式会社 | 抗cd137抗原结合分子及其应用 |
| KR20210078517A (ko) | 2018-10-16 | 2021-06-28 | 유씨비 바이오파마 에스알엘 | 중증근무력증의 치료 방법 |
| CN112996813A (zh) * | 2018-10-31 | 2021-06-18 | 生物蛋白有限公司 | 抗ctla4抗体、抗体片段、其免疫结合物和其用途 |
| WO2020230834A1 (en) | 2019-05-15 | 2020-11-19 | Chugai Seiyaku Kabushiki Kaisha | An antigen-binding molecule, a pharmaceutical composition, and a method |
| MX2021014756A (es) | 2019-06-07 | 2022-01-18 | Argenx Bvba | Formulaciones farmaceuticas de inhibidores de fcrn adecuadas para administracion subcutanea. |
| JP2022542430A (ja) * | 2019-08-01 | 2022-10-03 | ヤンセン バイオテツク，インコーポレーテツド | Ｆｃｒｎ抗体およびその使用の方法 |
| CN115836086A (zh) | 2020-01-08 | 2023-03-21 | 阿尔金克斯有限公司 | 治疗天疱疮病症的方法 |
| CN114341184B (zh) * | 2020-02-10 | 2023-04-04 | 北京拓界生物医药科技有限公司 | 抗FcRn抗体、其抗原结合片段及其医药用途 |
| KR102507515B1 (ko) * | 2020-08-26 | 2023-03-08 | 이화여자대학교 산학협력단 | 신규 항체 라이브러리 제조방법 및 이로부터 제조된 라이브러리 |
| CN116234827A (zh) * | 2021-09-03 | 2023-06-06 | 舒泰神（北京）生物制药股份有限公司 | 特异性识别FcRn的抗体及其应用 |
| CA3254741A1 (en) | 2022-05-30 | 2023-12-07 | Hanall Biopharma Co., Ltd. | ANTI-FCRN ANTIBODY OR ANTIGEN-BINDING FRAGMENT OF FCRN EXHIBITING IMPROVED STABILITY |
| AU2023290529A1 (en) | 2022-06-15 | 2024-12-12 | argenx BV | Fcrn/antigen-binding molecules and methods of use |
| CN115645537A (zh) * | 2022-10-25 | 2023-01-31 | 成都臻拓医药科技有限公司 | FcRn抑制剂在制备抑制自身免疫性疾病复发的药物中的用途 |
| CN116047054A (zh) * | 2023-03-08 | 2023-05-02 | 江西赛基生物技术有限公司 | 用于检测血小板抗体的试剂盒及其制备方法和使用方法 |
| WO2025099576A1 (en) * | 2023-11-06 | 2025-05-15 | Momenta Pharmaceuticals, Inc. | Compositions and methods for treating rheumatoid arthritis |
| GB202318512D0 (en) * | 2023-12-04 | 2024-01-17 | argenx BV | Methods of determining potency |
Family Cites Families (63)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3940475A (en) | 1970-06-11 | 1976-02-24 | Biological Developments, Inc. | Radioimmune method of assaying quantitatively for a hapten |
| US3867517A (en) | 1971-12-21 | 1975-02-18 | Abbott Lab | Direct radioimmunoassay for antigens and their antibodies |
| US4289747A (en) | 1978-12-26 | 1981-09-15 | E-Y Laboratories, Inc. | Immunological determination using lectin |
| DE2901218A1 (de) | 1979-01-13 | 1980-07-17 | Byk Gulden Lomberg Chem Fab | Ung von theophyllin |
| US4399216A (en) | 1980-02-25 | 1983-08-16 | The Trustees Of Columbia University | Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials |
| US5179017A (en) | 1980-02-25 | 1993-01-12 | The Trustees Of Columbia University In The City Of New York | Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials |
| US4634665A (en) | 1980-02-25 | 1987-01-06 | The Trustees Of Columbia University In The City Of New York | Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials |
| US4376110A (en) | 1980-08-04 | 1983-03-08 | Hybritech, Incorporated | Immunometric assays using monoclonal antibodies |
| US4522811A (en) | 1982-07-08 | 1985-06-11 | Syntex (U.S.A.) Inc. | Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides |
| US5374548A (en) | 1986-05-02 | 1994-12-20 | Genentech, Inc. | Methods and compositions for the attachment of proteins to liposomes using a glycophospholipid anchor |
| MX9203291A (es) | 1985-06-26 | 1992-08-01 | Liposome Co Inc | Metodo para acoplamiento de liposomas. |
| US4868103A (en) | 1986-02-19 | 1989-09-19 | Enzo Biochem, Inc. | Analyte detection by means of energy transfer |
| US5225539A (en) | 1986-03-27 | 1993-07-06 | Medical Research Council | Recombinant altered antibodies and methods of making altered antibodies |
| GB8607679D0 (en) | 1986-03-27 | 1986-04-30 | Winter G P | Recombinant dna product |
| DE3875456T3 (de) | 1987-11-09 | 1998-06-10 | Becton Dickinson Co | Verfahren zur Analyse hämatopoietischer Zellen in einer Probe. |
| US5223409A (en) | 1988-09-02 | 1993-06-29 | Protein Engineering Corp. | Directed evolution of novel binding proteins |
| DE68927933T2 (de) | 1988-09-02 | 1997-08-14 | Dyax Corp | Herstellung und auswahl von rekombinantproteinen mit verschiedenen bindestellen |
| US5750373A (en) | 1990-12-03 | 1998-05-12 | Genentech, Inc. | Enrichment method for variant proteins having altered binding properties, M13 phagemids, and growth hormone variants |
| US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| US5030002A (en) | 1989-08-11 | 1991-07-09 | Becton, Dickinson And Company | Method and apparatus for sorting particles with a moving catcher tube |
| US5427908A (en) | 1990-05-01 | 1995-06-27 | Affymax Technologies N.V. | Recombinant library screening methods |
| EP0585287B1 (en) | 1990-07-10 | 1999-10-13 | Cambridge Antibody Technology Limited | Methods for producing members of specific binding pairs |
| GB9015198D0 (en) | 1990-07-10 | 1990-08-29 | Brien Caroline J O | Binding substance |
| IE76732B1 (en) | 1990-08-07 | 1997-11-05 | Becton Dickinson Co | One step test for absolute counts |
| US5179107A (en) | 1990-09-07 | 1993-01-12 | Schering Corporation | Antiviral quinolinone compounds |
| US5370901A (en) | 1991-02-15 | 1994-12-06 | Bracco International B.V. | Compositions for increasing the image contrast in diagnostic investigations of the digestive tract of patients |
| AU1545692A (en) | 1991-03-01 | 1992-10-06 | Protein Engineering Corporation | Process for the development of binding mini-proteins |
| US5658727A (en) | 1991-04-10 | 1997-08-19 | The Scripps Research Institute | Heterodimeric receptor libraries using phagemids |
| DK0590058T3 (da) | 1991-06-14 | 2004-03-29 | Genentech Inc | Humaniseret heregulin-antistof |
| DE4122599C2 (de) | 1991-07-08 | 1993-11-11 | Deutsches Krebsforsch | Phagemid zum Screenen von Antikörpern |
| EP0552108B1 (en) | 1992-01-17 | 1999-11-10 | Lakowicz, Joseph R. | Energy transfer phase-modulation fluoro-immunoassay |
| SE9201984D0 (sv) | 1992-06-29 | 1992-06-29 | Pharmacia Biosensor Ab | Improvement in optical assays |
| US5827690A (en) | 1993-12-20 | 1998-10-27 | Genzyme Transgenics Corporatiion | Transgenic production of antibodies in milk |
| US6030613A (en) | 1995-01-17 | 2000-02-29 | The Brigham And Women's Hospital, Inc. | Receptor specific transepithelial transport of therapeutics |
| US6086875A (en) | 1995-01-17 | 2000-07-11 | The Brigham And Women's Hospital, Inc. | Receptor specific transepithelial transport of immunogens |
| AU5632296A (en) | 1995-04-27 | 1996-11-18 | Abgenix, Inc. | Human antibodies derived from immunized xenomice |
| WO1996034096A1 (en) | 1995-04-28 | 1996-10-31 | Abgenix, Inc. | Human antibodies derived from immunized xenomice |
| JP4046354B2 (ja) * | 1996-03-18 | 2008-02-13 | ボード オブ リージェンツ，ザ ユニバーシティ オブ テキサス システム | 増大した半減期を有する免疫グロブリン様ドメイン |
| EP2305027B1 (en) | 1996-12-03 | 2014-07-02 | Amgen Fremont Inc. | Transgenic mammals having human Ig loci including plural VH and Vkappa regions and antibodies produced therefrom |
| WO1998031700A1 (en) | 1997-01-21 | 1998-07-23 | The General Hospital Corporation | Selection of proteins using rna-protein fusions |
| CA2290485C (en) | 1997-05-21 | 2008-08-05 | Biovation Limited | Method for the production of non-immunogenic proteins |
| JP2002510505A (ja) | 1998-04-03 | 2002-04-09 | フィロス インク． | 位置特定可能な蛋白質アレイ |
| GB9809951D0 (en) * | 1998-05-08 | 1998-07-08 | Univ Cambridge Tech | Binding molecules |
| ATE352559T1 (de) | 1998-12-08 | 2007-02-15 | Biovation Ltd | Verfahren zur verminderung der immunogenität von proteinen |
| US6472147B1 (en) | 1999-05-25 | 2002-10-29 | The Scripps Research Institute | Methods for display of heterodimeric proteins on filamentous phage using pVII and pIX, compositions, vectors and combinatorial libraries |
| GB9928787D0 (en) | 1999-12-03 | 2000-02-02 | Medical Res Council | Direct screening method |
| US6960178B2 (en) | 2000-02-02 | 2005-11-01 | Xepmed, Inc. | Apparatus for enhanced plasmapheresis and methods thereof |
| US6992234B2 (en) | 2000-11-06 | 2006-01-31 | The Jackson Laboratory | FcRn-based therapeutics for the treatment of auto-immune disorders |
| US20030186374A1 (en) | 2001-10-01 | 2003-10-02 | Hufton Simon E. | Multi-chain eukaryotic display vectors and uses thereof |
| WO2003035842A2 (en) | 2001-10-24 | 2003-05-01 | Dyax Corporation | Hybridization control of sequence variation |
| US20050079169A1 (en) | 2003-08-08 | 2005-04-14 | Balthasar Joseph P. | Anti-FcRn antibodies for treatment of auto/allo immune conditions |
| US7662928B2 (en) * | 2003-08-08 | 2010-02-16 | The Research Foundation Of State University Of New York | Anti-FcRn antibodies for treatment of auto/allo immune conditions |
| US20100266530A1 (en) * | 2005-04-29 | 2010-10-21 | The Jackson Laboratory | FcRN ANTIBODIES AND USES THEREOF |
| US20090092507A1 (en) * | 2005-08-05 | 2009-04-09 | Ramirez Jr Emilio A | Fluid pump systems |
| CA2637929A1 (en) * | 2006-01-25 | 2007-08-02 | The Research Foundation Of State University Of New York | Anti-fcrn antibodies for treatement of auto/allo immune conditions |
| US8359965B2 (en) | 2007-09-17 | 2013-01-29 | Oxford J Craig | Apparatus and method for broad spectrum radiation attenuation |
| PH12021552811A1 (en) | 2007-09-26 | 2022-11-21 | Chugai Pharmaceutical Co Ltd | Modified antibody constant region |
| AR068723A1 (es) | 2007-10-05 | 2009-12-02 | Glaxo Group Ltd | Proteina que se une a antigenos que se une a il-23 humana y sus usos |
| CA2722082C (en) * | 2008-04-25 | 2021-11-09 | Christopher Tenhoor | Fc receptor binding proteins |
| PH12013502378A1 (en) * | 2011-06-02 | 2014-01-06 | Dyax Corp | Fc RECEPTOR BINDING PROTEINS |
| AU2018380979B2 (en) * | 2017-12-08 | 2023-07-20 | argenx BV | Use of FcRn antagonists for treatment of generalized myasthenia gravis |
| MX2020013195A (es) * | 2018-06-08 | 2021-02-26 | Argenx Bvba | Composiciones y metodos para el tratamiento de la trombocitopenia inmunitaria. |
| US20220298241A1 (en) * | 2019-05-17 | 2022-09-22 | Alexion Pharmaceuticals, Inc. | Use of anti-fcrn antibodies in the treatment of pemphighus and pemphigoid diseases |
-
2009
- 2009-04-24 CA CA2722082A patent/CA2722082C/en active Active
- 2009-04-24 CA CA3131470A patent/CA3131470A1/en active Pending
- 2009-04-24 MX MX2010011679A patent/MX2010011679A/es active IP Right Grant
- 2009-04-24 KR KR1020167016843A patent/KR101837329B1/ko active Active
- 2009-04-24 US US12/429,529 patent/US8273351B2/en active Active
- 2009-04-24 TW TW105116324A patent/TWI593423B/zh active
- 2009-04-24 EP EP17195757.4A patent/EP3348573B1/en active Active
- 2009-04-24 SG SG10202105499WA patent/SG10202105499WA/en unknown
- 2009-04-24 CN CN201410357602.2A patent/CN104479017A/zh active Pending
- 2009-04-24 EP EP09734929.4A patent/EP2310415B8/en active Active
- 2009-04-24 CN CN201710530059.5A patent/CN108467431A/zh active Pending
- 2009-04-24 JP JP2011506301A patent/JP6106854B2/ja active Active
- 2009-04-24 KR KR1020107026415A patent/KR101634719B1/ko active Active
- 2009-04-24 AU AU2009238605A patent/AU2009238605B2/en not_active Expired - Fee Related
- 2009-04-24 TW TW098113830A patent/TWI453031B/zh active
- 2009-04-24 KR KR1020197025353A patent/KR20190104432A/ko not_active Ceased
- 2009-04-24 ES ES09734929.4T patent/ES2650804T3/es active Active
- 2009-04-24 SG SG10201804513WA patent/SG10201804513WA/en unknown
- 2009-04-24 EP EP19210915.5A patent/EP3670538A1/en active Pending
- 2009-04-24 TW TW103126334A patent/TWI547287B/zh active
- 2009-04-24 NZ NZ589451A patent/NZ589451A/en unknown
- 2009-04-24 BR BR122021026834-7A patent/BR122021026834B1/pt active IP Right Grant
- 2009-04-24 BR BRPI0910622-7A patent/BRPI0910622A2/pt not_active Application Discontinuation
- 2009-04-24 SG SG2014004063A patent/SG196839A1/en unknown
- 2009-04-24 CN CN200980124409.1A patent/CN102149729B/zh active Active
- 2009-04-24 WO PCT/US2009/002536 patent/WO2009131702A2/en not_active Ceased
- 2009-04-24 KR KR1020177030420A patent/KR102072896B1/ko active Active
-
2010
- 2010-10-20 IL IL208846A patent/IL208846A/en active IP Right Grant
- 2010-11-03 ZA ZA2010/07873A patent/ZA201007873B/en unknown
-
2012
- 2012-08-13 US US13/584,221 patent/US20130045218A1/en not_active Abandoned
- 2012-09-14 US US13/617,498 patent/US8815246B2/en active Active
-
2014
- 2014-01-30 US US14/168,839 patent/US9260520B2/en active Active
-
2015
- 2015-02-16 JP JP2015027638A patent/JP5989159B2/ja active Active
- 2015-08-06 HK HK15107570.6A patent/HK1207089A1/xx unknown
- 2015-09-03 IL IL241091A patent/IL241091B/en active IP Right Grant
- 2015-12-22 US US14/979,165 patent/US20160222108A1/en not_active Abandoned
- 2015-12-29 US US14/982,649 patent/US20160222110A1/en not_active Abandoned
- 2015-12-29 US US14/982,521 patent/US20160222109A1/en not_active Abandoned
- 2015-12-30 US US14/984,075 patent/US20160222111A1/en not_active Abandoned
- 2015-12-30 US US14/984,162 patent/US20160222112A1/en not_active Abandoned
- 2015-12-31 US US14/985,614 patent/US20160194397A1/en not_active Abandoned
-
2016
- 2016-08-08 JP JP2016155218A patent/JP6499132B2/ja active Active
-
2019
- 2019-03-14 JP JP2019046955A patent/JP2019162105A/ja active Pending
-
2022
- 2022-05-02 JP JP2022075914A patent/JP2022115960A/ja active Pending