JP2011522877A5 - - Google Patents
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- Publication number
- JP2011522877A5 JP2011522877A5 JP2011513075A JP2011513075A JP2011522877A5 JP 2011522877 A5 JP2011522877 A5 JP 2011522877A5 JP 2011513075 A JP2011513075 A JP 2011513075A JP 2011513075 A JP2011513075 A JP 2011513075A JP 2011522877 A5 JP2011522877 A5 JP 2011522877A5
- Authority
- JP
- Japan
- Prior art keywords
- imidazol
- methylpyridin
- quinoline
- fluoro
- methyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12/155,984 | 2008-06-12 | ||
| US12/155,984 US20080319012A1 (en) | 2004-04-21 | 2008-06-12 | 2-Pyridyl substituted imidazoles as ALK5 and/or ALK4 inhibitors |
| PCT/IB2009/006398 WO2009150547A2 (en) | 2008-06-12 | 2009-06-11 | 2-pyridyl substituted imidazoles as alk4 and/or alk4 inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2011522877A JP2011522877A (ja) | 2011-08-04 |
| JP2011522877A5 true JP2011522877A5 (enExample) | 2012-06-28 |
Family
ID=41417193
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011513075A Pending JP2011522877A (ja) | 2008-06-12 | 2009-06-11 | Ａｌｋ５及び／又はａｌｋ４抑制体としての２‐ピリジルが置換されたイミダゾール類 |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US20080319012A1 (enExample) |
| EP (1) | EP2303860A4 (enExample) |
| JP (1) | JP2011522877A (enExample) |
| KR (1) | KR101654859B1 (enExample) |
| CN (1) | CN102083811B (enExample) |
| AU (1) | AU2009259021A1 (enExample) |
| BR (1) | BRPI0909899A2 (enExample) |
| CA (1) | CA2727607A1 (enExample) |
| IL (1) | IL209915A (enExample) |
| MX (1) | MX2010013549A (enExample) |
| RU (1) | RU2011100781A (enExample) |
| WO (1) | WO2009150547A2 (enExample) |
| ZA (1) | ZA201100277B (enExample) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20080319012A1 (en) * | 2004-04-21 | 2008-12-25 | In2Gen Co., Ltd. | 2-Pyridyl substituted imidazoles as ALK5 and/or ALK4 inhibitors |
| EP2264017A4 (en) * | 2008-04-04 | 2011-07-27 | Takeda Pharmaceutical | Heterocyclic derivative and its use |
| US8513222B2 (en) | 2010-06-29 | 2013-08-20 | EWHA University—Industry Collaboration Foundation | Methods of treating fibrosis, cancer and vascular injuries |
| US8080568B1 (en) * | 2010-06-29 | 2011-12-20 | Ewha University - Industry Collaboration Foundation | 2-pyridyl substituted imidazoles as therapeutic ALK5 and/or ALK4 inhibitors |
| USRE47141E1 (en) | 2010-06-29 | 2018-11-27 | EWHA University—Industry Collaboration Foundation | Methods of treating fibrosis, cancer and vascular injuries |
| USRE47009E1 (en) | 2011-02-01 | 2018-08-28 | The Children's Hospital Of Philadelphia | HDAC inhibitors and therapeutic methods using the same |
| CA2841252C (en) * | 2011-07-13 | 2019-02-26 | Sk Chemicals Co., Ltd. | 2-pyridyl substituted imidazoles as alk5 and/or alk4 inhibitors |
| EP3894401A2 (en) | 2018-12-11 | 2021-10-20 | Theravance Biopharma R&D IP, LLC | Naphthyridine and quinoline derivatives useful as alk5 inhibitors |
| CN114728941A (zh) * | 2019-11-22 | 2022-07-08 | 施万生物制药研发Ip有限责任公司 | 作为alk5抑制剂的经取代的1,5-萘啶或喹啉 |
| AU2021205893A1 (en) | 2020-01-08 | 2022-06-23 | Synthis Therapeutics, Inc. | ALK5 inhibitor conjugates and uses thereof |
| AR122711A1 (es) * | 2020-06-25 | 2022-09-28 | Alchemedicine Inc | COMPUESTO HETEROCÍCLICO COMO INHIBIDOR DE CASEÍNA QUINASA 1d Y/O QUINASA 5 TIPO RECEPTOR DE ACTIVINA |
| WO2022063050A1 (zh) | 2020-09-28 | 2022-03-31 | 四川科伦博泰生物医药股份有限公司 | 吡唑类化合物及其制备方法和用途 |
| WO2024258967A1 (en) | 2023-06-13 | 2024-12-19 | Synthis Therapeutics, Inc. | Anti-cd5 antibodies and their uses |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE60001229T2 (de) | 1999-04-09 | 2003-10-30 | Smithkline Beecham Corp., Philadelphia | Triarylimidazole |
| AR029803A1 (es) * | 2000-02-21 | 2003-07-16 | Smithkline Beecham Plc | Imidazoles sustituidos con piridilo y composiciones farmaceuticas que las comprenden |
| GB0007405D0 (en) | 2000-03-27 | 2000-05-17 | Smithkline Beecham Corp | Compounds |
| GB0100762D0 (en) | 2001-01-11 | 2001-02-21 | Smithkline Beecham Plc | Novel use |
| CA2448509A1 (en) | 2001-05-25 | 2002-12-05 | Mochida Pharmaceutical Co., Ltd. | 4-hydroxypiperidine derivatives having analgesic activity |
| AR039241A1 (es) | 2002-04-04 | 2005-02-16 | Biogen Inc | Heteroarilos trisustituidos y metodos para su produccion y uso de los mismos |
| HRP20050252A2 (en) * | 2002-09-18 | 2005-10-31 | Pfizer Products Inc. | Novel imidazole compounds as transforming growth factor (tfg) inhibitors |
| WO2005063716A1 (en) * | 2003-12-22 | 2005-07-14 | Janssen Pharmaceutica, N.V. | Imidazoles and their use cck-1 receptor modulators |
| US8420685B2 (en) * | 2004-04-21 | 2013-04-16 | Sk Chemicals Co., Ltd. | 2-pyridyl substituted imidazoles as ALK5 and/or ALK4 inhibitors |
| KR100749566B1 (ko) | 2004-04-21 | 2007-08-16 | 이화여자대학교 산학협력단 | Ａｌｋ5 및/또는 ａｌｋ4 억제제로 유효한 2-피리딜이치환된 이미다졸 유도체 |
| US20080319012A1 (en) * | 2004-04-21 | 2008-12-25 | In2Gen Co., Ltd. | 2-Pyridyl substituted imidazoles as ALK5 and/or ALK4 inhibitors |
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2008
- 2008-06-12 US US12/155,984 patent/US20080319012A1/en not_active Abandoned
-
2009
- 2009-06-11 CA CA2727607A patent/CA2727607A1/en not_active Abandoned
- 2009-06-11 EP EP09762075A patent/EP2303860A4/en not_active Withdrawn
- 2009-06-11 KR KR1020117000260A patent/KR101654859B1/ko not_active Expired - Fee Related
- 2009-06-11 WO PCT/IB2009/006398 patent/WO2009150547A2/en not_active Ceased
- 2009-06-11 RU RU2011100781/04A patent/RU2011100781A/ru not_active Application Discontinuation
- 2009-06-11 BR BRPI0909899A patent/BRPI0909899A2/pt not_active IP Right Cessation
- 2009-06-11 AU AU2009259021A patent/AU2009259021A1/en not_active Abandoned
- 2009-06-11 JP JP2011513075A patent/JP2011522877A/ja active Pending
- 2009-06-11 MX MX2010013549A patent/MX2010013549A/es active IP Right Grant
- 2009-06-11 CN CN200980121870.1A patent/CN102083811B/zh not_active Expired - Fee Related
-
2010
- 2010-12-09 IL IL209915A patent/IL209915A/en not_active IP Right Cessation
-
2011
- 2011-01-10 ZA ZA2011/00277A patent/ZA201100277B/en unknown
- 2011-06-22 US US13/067,737 patent/US20130245066A1/en not_active Abandoned