KR101654859B1 - Ａｌｋ5 및/또는 ａｌｋ4 저해제로서의 2-피리딜이 치환된 이미다졸 화합물 - Google Patents

Ａｌｋ5 및/또는 ａｌｋ4 저해제로서의 2-피리딜이 치환된 이미다졸 화합물 Download PDF

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KR101654859B1
KR101654859B1 KR1020117000260A KR20117000260A KR101654859B1 KR 101654859 B1 KR101654859 B1 KR 101654859B1 KR 1020117000260 A KR1020117000260 A KR 1020117000260A KR 20117000260 A KR20117000260 A KR 20117000260A KR 101654859 B1 KR101654859 B1 KR 101654859B1
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imidazol
methylpyridin
quinoline
methyl
fluoro
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KR20110022662A (ko
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이주영
김재선
오정훈
정회철
이현정
강상환
김용혁
박성훈
류근호
이정범
김훈택
엄기안
이봉용
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에스케이케미칼주식회사
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KR1020117000260A 2008-06-12 2009-06-11 Ａｌｋ5 및/또는 ａｌｋ4 저해제로서의 2-피리딜이 치환된 이미다졸 화합물 Expired - Fee Related KR101654859B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US12/155,984 US20080319012A1 (en) 2004-04-21 2008-06-12 2-Pyridyl substituted imidazoles as ALK5 and/or ALK4 inhibitors
US12/155,984 2008-06-12

Publications (2)

Publication Number Publication Date
KR20110022662A KR20110022662A (ko) 2011-03-07
KR101654859B1 true KR101654859B1 (ko) 2016-09-07

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KR1020117000260A Expired - Fee Related KR101654859B1 (ko) 2008-06-12 2009-06-11 Ａｌｋ5 및/또는 ａｌｋ4 저해제로서의 2-피리딜이 치환된 이미다졸 화합물

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US (2) US20080319012A1 (enExample)
EP (1) EP2303860A4 (enExample)
JP (1) JP2011522877A (enExample)
KR (1) KR101654859B1 (enExample)
CN (1) CN102083811B (enExample)
AU (1) AU2009259021A1 (enExample)
BR (1) BRPI0909899A2 (enExample)
CA (1) CA2727607A1 (enExample)
IL (1) IL209915A (enExample)
MX (1) MX2010013549A (enExample)
RU (1) RU2011100781A (enExample)
WO (1) WO2009150547A2 (enExample)
ZA (1) ZA201100277B (enExample)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080319012A1 (en) * 2004-04-21 2008-12-25 In2Gen Co., Ltd. 2-Pyridyl substituted imidazoles as ALK5 and/or ALK4 inhibitors
CA2720343A1 (en) * 2008-04-04 2009-10-08 Takeda Pharmaceutical Company Limited Heterocyclic derivative and use thereof
US8080568B1 (en) 2010-06-29 2011-12-20 Ewha University - Industry Collaboration Foundation 2-pyridyl substituted imidazoles as therapeutic ALK5 and/or ALK4 inhibitors
US8513222B2 (en) 2010-06-29 2013-08-20 EWHA University—Industry Collaboration Foundation Methods of treating fibrosis, cancer and vascular injuries
USRE47141E1 (en) 2010-06-29 2018-11-27 EWHA University—Industry Collaboration Foundation Methods of treating fibrosis, cancer and vascular injuries
CA2825599C (en) 2011-02-01 2021-07-13 The Board Of Trustees Of The University Of Illinois 4-methyl-n-hydroxybenzamide compounds as histone deacetylase (hdac) inhibitors
PT2731949T (pt) * 2011-07-13 2018-06-15 Tiumbio Co Ltd Imidazóis substituídos com 2-piridilo como inibidores de alk5 e/ou alk4
US10952996B2 (en) 2018-12-11 2021-03-23 Theravance Biopharma R&D Ip, Llc ALK5 inhibitors
KR20220104208A (ko) * 2019-11-22 2022-07-26 세라밴스 바이오파마 알앤디 아이피, 엘엘씨 Alk5 억제제로서 치환된 1,5-나프티리딘 또는 퀴놀린
CA3164037A1 (en) 2020-01-08 2021-07-15 Synthis Therapeutics, Inc. Alk5 inhibitor conjugates and uses thereof
AR122711A1 (es) * 2020-06-25 2022-09-28 Alchemedicine Inc COMPUESTO HETEROCÍCLICO COMO INHIBIDOR DE CASEÍNA QUINASA 1d Y/O QUINASA 5 TIPO RECEPTOR DE ACTIVINA
JP2023542789A (ja) 2020-09-28 2023-10-12 シチュアン ケルン－バイオテック バイオファーマシューティカル カンパニー リミテッド ピラゾール化合物並びにその調製方法及び使用
WO2024258967A1 (en) 2023-06-13 2024-12-19 Synthis Therapeutics, Inc. Anti-cd5 antibodies and their uses

Citations (1)

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WO2005103028A1 (en) * 2004-04-21 2005-11-03 In2Gen Co., Ltd 2-pyridyl substituted imidazoles as alk5 and/or alk4 inhibitors

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JP2002541253A (ja) 1999-04-09 2002-12-03 スミスクライン・ビーチャム・コーポレイション トリアリールイミダゾール
AR029803A1 (es) * 2000-02-21 2003-07-16 Smithkline Beecham Plc Imidazoles sustituidos con piridilo y composiciones farmaceuticas que las comprenden
GB0007405D0 (en) 2000-03-27 2000-05-17 Smithkline Beecham Corp Compounds
GB0100762D0 (en) 2001-01-11 2001-02-21 Smithkline Beecham Plc Novel use
WO2002096875A1 (fr) 2001-05-25 2002-12-05 Mochida Pharmaceutical Co., Ltd. Derive de 4-hydroxypiperidine a activite analgesique
AR039241A1 (es) 2002-04-04 2005-02-16 Biogen Inc Heteroarilos trisustituidos y metodos para su produccion y uso de los mismos
OA12928A (en) * 2002-09-18 2006-10-13 Pfizer Prod Inc Novel imidazole compounds as transforming growth factor (TGF) inhibitors.
WO2005063716A1 (en) * 2003-12-22 2005-07-14 Janssen Pharmaceutica, N.V. Imidazoles and their use cck-1 receptor modulators
US8420685B2 (en) * 2004-04-21 2013-04-16 Sk Chemicals Co., Ltd. 2-pyridyl substituted imidazoles as ALK5 and/or ALK4 inhibitors
US20080319012A1 (en) * 2004-04-21 2008-12-25 In2Gen Co., Ltd. 2-Pyridyl substituted imidazoles as ALK5 and/or ALK4 inhibitors

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005103028A1 (en) * 2004-04-21 2005-11-03 In2Gen Co., Ltd 2-pyridyl substituted imidazoles as alk5 and/or alk4 inhibitors
KR100749566B1 (ko) 2004-04-21 2007-08-16 이화여자대학교 산학협력단 Ａｌｋ5 및/또는 ａｌｋ4 억제제로 유효한 2-피리딜이치환된 이미다졸 유도체

Non-Patent Citations (1)

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European Journal of Medicinal Chemistry, 44, 568-576(Available online 2008.04.04.)*

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CA2727607A1 (en) 2009-12-17
EP2303860A4 (en) 2011-07-06
MX2010013549A (es) 2011-06-22
EP2303860A2 (en) 2011-04-06
US20080319012A1 (en) 2008-12-25
CN102083811B (zh) 2014-01-22
BRPI0909899A2 (pt) 2016-02-16
US20130245066A1 (en) 2013-09-19
IL209915A (en) 2015-10-29
WO2009150547A3 (en) 2010-08-26
JP2011522877A (ja) 2011-08-04
AU2009259021A1 (en) 2009-12-17
WO2009150547A2 (en) 2009-12-17
KR20110022662A (ko) 2011-03-07
IL209915A0 (en) 2011-02-28
RU2011100781A (ru) 2012-07-20
CN102083811A (zh) 2011-06-01
ZA201100277B (en) 2012-03-28

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