JP2011522874A - 季節性および汎流行性の防御のための混合インフルエンザワクチン - Google Patents
季節性および汎流行性の防御のための混合インフルエンザワクチン Download PDFInfo
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- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
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- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
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- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/70—Multivalent vaccine
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16111—Influenzavirus A, i.e. influenza A virus
- C12N2760/16134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16211—Influenzavirus B, i.e. influenza B virus
- C12N2760/16234—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Virology (AREA)
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Applications Claiming Priority (5)
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| GB0905570.8 | 2009-03-31 | ||
| PCT/IB2009/006038 WO2009150532A1 (en) | 2008-06-12 | 2009-06-12 | Combined influenza vaccines for seasonal and pandemic protection |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2013048597A (ja) * | 2011-08-31 | 2013-03-14 | Tokyo Metropolitan Institute Of Medical Science | 新型インフルエンザウイルス由来ヘマグルチニンタンパク質遺伝子を有するＤＩｓ株由来組換えワクシニアウイルス |
| WO2016104584A1 (ja) * | 2014-12-25 | 2016-06-30 | 第一三共株式会社 | 皮内投与インフルエンザワクチン組成物 |
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| WO2010060430A2 (en) * | 2008-11-28 | 2010-06-03 | Statens Serum Institut | Optimized influenza vaccines |
| AU2015203072B2 (en) * | 2009-02-10 | 2017-05-25 | Seqirus UK Limited | Influenza vaccine regimens for pandemic-associated strains |
| ES2552383T3 (es) | 2009-02-10 | 2015-11-27 | Novartis Ag | Regímenes de vacuna de la gripe para cepas asociadas a pandemias |
| JP2012521786A (ja) | 2009-03-30 | 2012-09-20 | モウント シナイ スクール オフ メディシネ | インフルエンザウイルスワクチン及びその使用 |
| CN102548577A (zh) * | 2009-04-27 | 2012-07-04 | 诺华有限公司 | 用于抵抗流感的佐剂疫苗 |
| CA2800182A1 (en) | 2009-05-26 | 2010-12-02 | Mount Sinai School Of Medicine | Monoclonal antibodies against influenza virus generated by cyclical administration and uses thereof |
| US20120219584A1 (en) * | 2009-10-05 | 2012-08-30 | The United States Of America As Represented By The Secretary, Department Of Health | Protection against pandemic and seasonal strains of influenza |
| WO2011103453A2 (en) | 2010-02-18 | 2011-08-25 | Mount Sinai School Of Medicine | Vaccines for use in the prophylaxis and treatment of influenza virus disease |
| CN102939103A (zh) | 2010-03-30 | 2013-02-20 | 西奈山医学院 | 流感病毒疫苗及其应用 |
| EP2758075B1 (en) | 2011-09-20 | 2023-05-03 | Icahn School of Medicine at Mount Sinai | Influenza virus vaccines and uses thereof |
| WO2013131898A1 (en) * | 2012-03-06 | 2013-09-12 | Crucell Holland B.V. | Improved vaccination against influenza |
| HK1215546A1 (zh) | 2012-12-17 | 2016-09-02 | Eurocine Vaccines Ab | 鼻内接种疫苗给药方案 |
| SG11201504728RA (en) | 2012-12-18 | 2015-07-30 | Icahn School Med Mount Sinai | Influenza virus vaccines and uses thereof |
| US9908930B2 (en) | 2013-03-14 | 2018-03-06 | Icahn School Of Medicine At Mount Sinai | Antibodies against influenza virus hemagglutinin and uses thereof |
| EP3060247A1 (en) * | 2013-10-25 | 2016-08-31 | Leukocare Ag | A novel method for the production of stabile vaccines |
| CN107847579A (zh) * | 2014-12-19 | 2018-03-27 | 俄勒冈健康与科学大学 | 人和禽h5n1流感的计算优化的广泛反应性抗原的协同共同给药 |
| JP2018504412A (ja) | 2015-01-23 | 2018-02-15 | アイカーン スクール オブ メディシン アット マウント サイナイ | インフルエンザウイルスワクチン接種レジメン |
| EP3313439A2 (en) | 2015-06-26 | 2018-05-02 | Seqirus UK Limited | Antigenically matched influenza vaccines |
| CN109641041A (zh) | 2016-06-15 | 2019-04-16 | 西奈山伊坎医学院 | 流感病毒血细胞凝集素蛋白及其用途 |
| CN107151659B (zh) * | 2017-03-01 | 2021-04-02 | 苏州系统医学研究所 | 一种流感病毒株及其应用 |
| EP3606555A4 (en) | 2017-04-07 | 2021-08-04 | Icahn School of Medicine at Mount Sinai | INFLUENZA VIRUS TYPE B ANTI-NEURAMINIDASE ANTIBODIES AND THEIR USES |
| AU2018357917B2 (en) | 2017-10-30 | 2024-08-01 | Takeda Pharmaceutical Company Limited | Environmentally compatible detergents for inactivation of lipid-enveloped viruses |
| WO2019143955A1 (en) * | 2018-01-22 | 2019-07-25 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Broadly protective inactivated influenza virus vaccine |
| US12364746B2 (en) | 2018-06-21 | 2025-07-22 | Icahn School Of Medicine At Mount Sinai | Mosaic influenza virus hemagglutinin polypeptides and uses thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2009023985A (ja) * | 2007-01-11 | 2009-02-05 | Osaka Prefecture Univ | インフルエンザウイルスに対する抗体の産生方法 |
| JP2011506264A (ja) * | 2006-12-06 | 2011-03-03 | ノバルティス アーゲー | インフルエンザウイルスの４つの株に由来する抗原を含むワクチン |
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| EP1645283A1 (en) * | 2004-10-08 | 2006-04-12 | Chiron Behring GmbH & Co. KG | Combination vaccine |
| CA2602456A1 (en) * | 2005-03-23 | 2006-09-28 | Glaxosmithkline Biologicals S.A. | Composition |
| EP1951302A2 (en) * | 2005-11-04 | 2008-08-06 | Novartis Vaccines and Diagnostics S.r.l. | Influenza vaccine with reduced amount of oil-in-water emulsion as adjuvant |
| AU2006310341B2 (en) * | 2005-11-04 | 2011-01-06 | Novartis Vaccines And Diagnostics Limited | Influenza vaccines extemporaneously adsorbed to aluminium adjuvants |
| WO2007144772A2 (en) * | 2006-06-15 | 2007-12-21 | Novartis Ag | Adjuvant-sparing multi-dose influenza vaccination regimen |
| EP2497495B3 (en) * | 2006-09-11 | 2021-02-17 | Seqirus UK Limited | Making influenza virus vaccines without using eggs |
| TWI403518B (zh) * | 2007-01-23 | 2013-08-01 | Academia Sinica | 一種流感疫苗及其使用方法 |
| GB0810305D0 (en) * | 2008-06-05 | 2008-07-09 | Novartis Ag | Influenza vaccination |
| EP2227251A1 (en) * | 2007-12-06 | 2010-09-15 | GlaxoSmithKline Biologicals SA | Influenza composition |
| AU2009227674C1 (en) * | 2008-03-18 | 2015-01-29 | Seqirus UK Limited | Improvements in preparation of influenza virus vaccine antigens |
-
2009
- 2009-03-31 GB GBGB0905570.8A patent/GB0905570D0/en not_active Ceased
- 2009-06-12 WO PCT/IB2009/006038 patent/WO2009150532A1/en not_active Ceased
- 2009-06-12 US US12/997,577 patent/US20110200635A1/en not_active Abandoned
- 2009-06-12 JP JP2011513069A patent/JP2011522874A/ja active Pending
- 2009-06-12 CN CN2009801230987A patent/CN102245203A/zh active Pending
- 2009-06-12 AU AU2009259006A patent/AU2009259006A1/en not_active Abandoned
- 2009-06-12 EP EP09762060A patent/EP2303321A1/en not_active Withdrawn
- 2009-06-12 KR KR1020117000394A patent/KR20110019417A/ko not_active Ceased
- 2009-06-12 CA CA2727322A patent/CA2727322A1/en not_active Abandoned
-
2014
- 2014-08-18 US US14/461,852 patent/US20140363468A1/en not_active Abandoned
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2011506264A (ja) * | 2006-12-06 | 2011-03-03 | ノバルティス アーゲー | インフルエンザウイルスの４つの株に由来する抗原を含むワクチン |
| JP2009023985A (ja) * | 2007-01-11 | 2009-02-05 | Osaka Prefecture Univ | インフルエンザウイルスに対する抗体の産生方法 |
Non-Patent Citations (2)
| Title |
|---|
| JPN6013048992; 三和護: ''【学会トピックス】ダチョウの卵から生まれた鳥インフルエンザ抗体マスク'' ［ｏｎｌｉｎｅ］日経メディカルオンライン , 20080118 * |
| JPN6013048993; Ｏｎｉｓｈｃｈｅｎｋｏ ｅｔ ａｌ．: ''Ｔｅｔｒａｖａｃｃｉｎｅ - ｎｅｗ ｆｕｎｄａｍｅｎｔａｌ ａｐｐｒｏａｃｈ ｔｏ ｐｒｅｖｅｎｔｉｏｎ ｏｆ ｉｎｆｌｕｅｎｚａ ｐａｎｄｅｍｉｃ'' Ｚｈｕｒｎａｌ ｍｉｋｒｏｂｉｏｌｏｇｉｉ， ｅｐｉｄｅｍｉｏｌｏｇｉｉ， ｉ ｉｍｍｕｎｏｂｉｏｌｏｇｉｉ， Ｎｏ．４, 2007, ｐｐ．１５-１９ * |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2013048597A (ja) * | 2011-08-31 | 2013-03-14 | Tokyo Metropolitan Institute Of Medical Science | 新型インフルエンザウイルス由来ヘマグルチニンタンパク質遺伝子を有するＤＩｓ株由来組換えワクシニアウイルス |
| WO2016104584A1 (ja) * | 2014-12-25 | 2016-06-30 | 第一三共株式会社 | 皮内投与インフルエンザワクチン組成物 |
| JPWO2016104584A1 (ja) * | 2014-12-25 | 2017-10-05 | 第一三共株式会社 | 皮内投与インフルエンザワクチン組成物 |
| JP2020122003A (ja) * | 2014-12-25 | 2020-08-13 | テルモ株式会社 | 皮内投与インフルエンザワクチン組成物 |
Also Published As
| Publication number | Publication date |
|---|---|
| CN102245203A (zh) | 2011-11-16 |
| GB0905570D0 (en) | 2009-05-13 |
| US20110200635A1 (en) | 2011-08-18 |
| WO2009150532A1 (en) | 2009-12-17 |
| US20140363468A1 (en) | 2014-12-11 |
| CA2727322A1 (en) | 2009-12-17 |
| KR20110019417A (ko) | 2011-02-25 |
| EP2303321A1 (en) | 2011-04-06 |
| AU2009259006A1 (en) | 2009-12-17 |
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