JP2011521896A - 免疫関連障害に対する局部治療に使用するための局所lfa−1アンタゴニスト - Google Patents

免疫関連障害に対する局部治療に使用するための局所lfa−1アンタゴニスト Download PDF

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JP2011521896A
JP2011521896A JP2011505028A JP2011505028A JP2011521896A JP 2011521896 A JP2011521896 A JP 2011521896A JP 2011505028 A JP2011505028 A JP 2011505028A JP 2011505028 A JP2011505028 A JP 2011505028A JP 2011521896 A JP2011521896 A JP 2011521896A
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lfa
antagonist
formulation
aryl
heteroaryl
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JP2011521896A5 (cg-RX-API-DMAC7.html
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ジョン バーニアー,
トーマス ガデック,
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サーコード コーポレイション
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    • C07D405/06Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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JP2011505028A 2008-04-15 2009-04-15 免疫関連障害に対する局部治療に使用するための局所lfa−1アンタゴニスト Withdrawn JP2011521896A (ja)

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US4524008P 2008-04-15 2008-04-15
US61/045,240 2008-04-15
PCT/US2009/002389 WO2009128934A1 (en) 2008-04-15 2009-04-15 Topical lfa-1 antagonists for use in localized treatment of immune related disorders

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JP2014080832A Division JP2014132032A (ja) 2008-04-15 2014-04-10 免疫関連障害に対する局部治療に使用するための局所lfa−1アンタゴニスト

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JP2011521896A true JP2011521896A (ja) 2011-07-28
JP2011521896A5 JP2011521896A5 (cg-RX-API-DMAC7.html) 2012-06-07

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JP2011505028A Withdrawn JP2011521896A (ja) 2008-04-15 2009-04-15 免疫関連障害に対する局部治療に使用するための局所lfa−1アンタゴニスト
JP2014080832A Pending JP2014132032A (ja) 2008-04-15 2014-04-10 免疫関連障害に対する局部治療に使用するための局所lfa−1アンタゴニスト

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US (2) US20090258070A1 (cg-RX-API-DMAC7.html)
EP (2) EP2265125B1 (cg-RX-API-DMAC7.html)
JP (2) JP2011521896A (cg-RX-API-DMAC7.html)
CN (1) CN102056485A (cg-RX-API-DMAC7.html)
ES (1) ES2763703T3 (cg-RX-API-DMAC7.html)
WO (1) WO2009128934A1 (cg-RX-API-DMAC7.html)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2011516607A (ja) * 2008-04-15 2011-05-26 サーコード コーポレイション 胃腸系へのlfa−1アンタゴニストの送達
JP2011518155A (ja) * 2008-04-15 2011-06-23 サーコード コーポレイション 免疫関連障害の局所治療に使用するためのエアゾール化lfa−1アンタゴニスト
JP2022546120A (ja) * 2019-09-03 2022-11-02 スクエア パワー リミテッド セリアック病の予防および治療に使用するためのレバミピド
WO2024058212A1 (ja) * 2022-09-15 2024-03-21 日油株式会社 コンタクトレンズ用溶液

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2383525T3 (es) 2003-11-05 2012-06-21 Sarcode Bioscience Inc. Moduladores de la adhesión celular
JP5794721B2 (ja) * 2005-05-17 2015-10-14 サーコード バイオサイエンス インコーポレイテッド 眼障害の治療のための組成物および方法
EP1915620B1 (en) 2005-08-02 2010-06-02 Xbiotech Inc DIAGNOSIS, TREATMENT, AND PREVENTION OF VASCULAR DISORDERS USING IL-1alpha AUTOANTIBODIES
ES2630406T3 (es) 2007-10-19 2017-08-21 Sarcode Bioscience Inc. Composición y procedimientos para el tratamiento de la retinopatía diabética
PL2285409T3 (pl) 2008-05-30 2016-10-31 Przeciwciała il-1 alfa
JP5976319B2 (ja) 2008-09-12 2016-08-23 エックスバイオテク, インコーポレイテッドXbiotech, Inc. 病原性単球の標的化
US8962026B2 (en) * 2008-09-26 2015-02-24 The Regents Of The University Of Michigan Nanoemulsion therapeutic compositions and methods of using the same
EP2395839B1 (en) * 2009-02-13 2014-05-07 Topica Pharmaceuticals, Inc Anti-fungal formulation
JP2013516459A (ja) * 2010-01-20 2013-05-13 カディラ・ヘルスケア・リミテッド ピタバスタチン及び医薬として許容可能なそれらの塩の製造方法
KR20180086297A (ko) 2010-06-18 2018-07-30 엑스바이오테크, 인크. 관절염 치료
KR101910760B1 (ko) 2010-08-23 2018-10-22 엑스바이오테크, 인크. 종양성 질병들에 대한 치료
US9724409B2 (en) 2011-04-01 2017-08-08 Xbiotech, Inc. Treatment of inflammatory skin disease
CA2849710C (en) 2011-09-23 2020-04-28 Xbiotech Inc. Cachexia treatment
WO2013108644A1 (ja) * 2012-01-20 2013-07-25 京都府公立大学法人 レバミピドのアレルギー性結膜炎治療剤
US9545441B2 (en) 2012-09-18 2017-01-17 Xbiotech, Inc. Treatment of diabetes
EP2934510B1 (en) 2012-12-19 2020-10-28 Novartis AG Lfa-1 inhibitor formulations
US9688943B2 (en) 2015-05-29 2017-06-27 beauty Avenues LLC Candle containing non-ionic emulsifer
US20200009130A1 (en) * 2016-12-16 2020-01-09 Sarcode Bioscience Inc. Ocular distribution and pharmacokinetics of lifitegrast formulations
EP3582813A4 (en) 2017-02-16 2020-12-30 XBiotech, Inc TREATMENT OF SUPPURATIVE HIDRADENITIS
CN106920239B (zh) * 2017-03-08 2019-10-18 福建师范大学 一种基于改进sift算法的图像关键点检测方法
TW201920956A (zh) * 2017-09-29 2019-06-01 日商參天製藥股份有限公司 淚液中之muc5ac量之測定方法
CN111787918A (zh) * 2017-11-29 2020-10-16 洛克菲勒大学 用于皮肤病学病况增强治疗的局部和全身性治疗的组合
KR20220003555A (ko) * 2019-04-18 2022-01-10 아주라 오프탈믹스 엘티디 안구 장애의 치료를 위한 화합물 및 방법
WO2021010843A1 (en) 2019-07-16 2021-01-21 Donaghys Limited Transdermal solvent system and methods of use
CN112494488B (zh) * 2020-06-17 2022-01-18 中国药科大学 瑞巴派特的防脱发和生发用途
US12393057B2 (en) * 2020-12-15 2025-08-19 Coopervision International Limited Oleic acid-releasing contact lens
CA3204617A1 (en) * 2020-12-29 2022-07-07 Next Science IP Holdings Pty Ltd Cancer treatment composition and method
CA3216947A1 (en) * 2021-06-14 2022-12-22 Protransit Nanotherapy Llc Cyclosporine compositions and methods of use thereof
CN115707698A (zh) * 2021-08-18 2023-02-21 辽宁何氏医学院 5,7-二氯-1,2,3,4-四氢异喹啉-6-甲酰胺类化合物及其制备方法和应用
US12161612B2 (en) 2023-04-14 2024-12-10 Neuroderm, Ltd. Methods and compositions for reducing symptoms of Parkinson's disease
WO2025223511A1 (zh) * 2024-04-25 2025-10-30 上海翊石医药科技有限公司 一类苯甲酰基甘氨酸衍生物及其制备方法和应用

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005044817A1 (en) * 2003-11-05 2005-05-19 Sunesis Pharmaceuticals, Inc. Modulators of cellular adhesion
WO2006125119A1 (en) * 2005-05-17 2006-11-23 Sarcode Corporation Compositions and methods for treatment of eye disorders
JP2011516607A (ja) * 2008-04-15 2011-05-26 サーコード コーポレイション 胃腸系へのlfa−1アンタゴニストの送達
JP2011518155A (ja) * 2008-04-15 2011-06-23 サーコード コーポレイション 免疫関連障害の局所治療に使用するためのエアゾール化lfa−1アンタゴニスト

Family Cites Families (66)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3989816A (en) 1975-06-19 1976-11-02 Nelson Research & Development Company Vehicle composition containing 1-substituted azacycloheptan-2-ones
US4316893A (en) 1975-06-19 1982-02-23 Nelson Research & Development Co. Vehicle composition containing 1-substituted azacycloalkan-2-ones
US4405616A (en) 1975-06-19 1983-09-20 Nelson Research & Development Company Penetration enhancers for transdermal drug delivery of systemic agents
US4557934A (en) 1983-06-21 1985-12-10 The Procter & Gamble Company Penetrating topical pharmaceutical compositions containing 1-dodecyl-azacycloheptan-2-one
US4524008A (en) 1983-12-16 1985-06-18 E. I. Du Pont De Nemours And Company Controlled initiation chromium dioxide synthesis
US4568343A (en) 1984-10-09 1986-02-04 Alza Corporation Skin permeation enhancer compositions
US5023252A (en) * 1985-12-04 1991-06-11 Conrex Pharmaceutical Corporation Transdermal and trans-membrane delivery of drugs
US4783450A (en) 1987-04-13 1988-11-08 Warner-Lambert Company Use of commercial lecithin as skin penetration enhancer
US5001139A (en) * 1987-06-12 1991-03-19 American Cyanamid Company Enchancers for the transdermal flux of nivadipine
US4992445A (en) * 1987-06-12 1991-02-12 American Cyanamid Co. Transdermal delivery of pharmaceuticals
DE3802996A1 (de) 1988-02-02 1989-08-10 Cassella Ag Verwendung von 2-oxo-pyrrolidin-1-acetamid zur bestimmung der glomerulaeren filtrationsrate beim menschen
US5424399A (en) * 1988-06-28 1995-06-13 The Children's Medical Center Corporation Human CR3α/β heterodimers
US5149780A (en) * 1988-10-03 1992-09-22 The Scripps Research Institute Peptides and antibodies that inhibit integrin-ligand binding
AU8631991A (en) * 1990-08-27 1992-03-17 Cetus Corporation Cd18 peptide medicaments for the treatment of disease
US5288854A (en) * 1990-11-28 1994-02-22 Center For Blood Research, Inc. Functional derivatives of ICAM-1 which are substantially capable of binding to LFA-1 but are substantially incapable of binding to MAC-1
WO1993006865A1 (en) * 1991-10-04 1993-04-15 The United States of America, represented by The Secretary, Department of Health & Human Services Treatment of ocular inflammation by blockage of cell adhesion molecules
US6764681B2 (en) * 1991-10-07 2004-07-20 Biogen, Inc. Method of prophylaxis or treatment of antigen presenting cell driven skin conditions using inhibitors of the CD2/LFA-3 interaction
US6162432A (en) * 1991-10-07 2000-12-19 Biogen, Inc. Method of prophylaxis or treatment of antigen presenting cell driven skin conditions using inhibitors of the CD2/LFA-3 interaction
WO1993017047A1 (en) * 1992-02-28 1993-09-02 Board Of Regents, The University Of Texas System Compositions and methods for the treatment of thermal injury
US5298492A (en) * 1992-08-04 1994-03-29 Schering Corporation Diamino acid derivatives as antihypertensives
AU687755B2 (en) * 1992-08-21 1998-03-05 Genentech Inc. Method for treating an LFA-1-mediated disorder
US5397791A (en) * 1993-08-09 1995-03-14 Merck & Co., Inc. Fibrinogen receptor antagonists
DE59409322D1 (de) * 1993-12-03 2000-06-08 Hoffmann La Roche Essigsäurederivate als Arzneimittel
US5470953A (en) * 1993-12-23 1995-11-28 Icos Corporation Human β2 integrin α subunit
US6228383B1 (en) 1994-03-03 2001-05-08 Gs Development Ab Use of fatty acid esters as bioadhesive substances
CA2188287A1 (en) 1994-04-19 1995-10-26 Stephen Benedict Icam-1/lfa-1 short-chain peptides and method of using same
US5585359A (en) * 1994-09-29 1996-12-17 Merck & Co., Inc. Inhibitors of farnesyl-protein transferase
ES2123889T3 (es) * 1994-11-02 1999-01-16 Merck Patent Gmbh Antagonistas de receptores de adhesion.
US5747035A (en) 1995-04-14 1998-05-05 Genentech, Inc. Polypeptides with increased half-life for use in treating disorders involving the LFA-1 receptor
ATE342295T1 (de) 1995-07-28 2006-11-15 Genzyme Corp Biologische abbaubare multiblokhydrogene und ihre verwendung wie trägerstoffe fur kontrollierte freisetzung pharmakologisch activen werstoffe und gewebekontaktmaterialen
CA2272565A1 (en) * 1996-11-27 1998-06-04 Du Pont Pharmaceuticals Company Integrin receptor antagonists
AR013445A1 (es) 1997-08-28 2000-12-27 Novartis Ag Antagonistas de lfa-1
US6541606B2 (en) * 1997-12-31 2003-04-01 Altus Biologics Inc. Stabilized protein crystals formulations containing them and methods of making them
EA007852B1 (ru) 1998-03-27 2007-02-27 Джинентех, Инк. Соединения для лечения расстройств, опосредованных рецепторами адгезии cd11/cd18
US6331640B1 (en) * 1998-10-13 2001-12-18 Hoffmann-La Roche Inc. Diaminopropionic acid derivatives
US6670321B1 (en) * 1998-12-30 2003-12-30 The Children's Medical Center Corporation Prevention and treatment for retinal ischemia and edema
ATE330631T1 (de) * 1999-01-05 2006-07-15 Univ Southern Australia Antikörperfragmente zur lokalen behandlung von augenerkrankungen
EP1028114A1 (en) * 1999-02-13 2000-08-16 Aventis Pharma Deutschland GmbH Novel guanidine derivatives as inhibitors of cell adhesion
US6605597B1 (en) * 1999-12-03 2003-08-12 Cv Therapeutics, Inc. Partial or full A1agonists-N-6 heterocyclic 5′-thio substituted adenosine derivatives
US6294522B1 (en) * 1999-12-03 2001-09-25 Cv Therapeutics, Inc. N6 heterocyclic 8-modified adenosine derivatives
EP1237575B1 (en) * 1999-12-14 2008-08-06 Genentech, Inc. Tnf-alpha antagonist and lfa-1 antagonist for treating rheumatoid arthritis
US6630447B2 (en) 2000-01-14 2003-10-07 University Of New Mexico Peptide inhibitors of LFA-1/ICAM-1 interaction
US6515124B2 (en) 2000-02-09 2003-02-04 Hoffman-La Roche Inc. Dehydroamino acids
WO2001085677A1 (fr) * 2000-05-05 2001-11-15 Societe De Conseils De Recherches Et D'applications Scientifiques (S.C.R.A.S.) Derives d'aminoacides et leur application a titre de medicaments
CA2414461A1 (en) * 2000-06-29 2002-01-10 Abbott Laboratories Aryl phenylheterocyclyl sulfide derivatives and their use as cell adhesion-inhibiting anti-inflammatory and immune-suppressive agents
PE20020420A1 (es) * 2000-10-02 2002-06-27 Novartis Ag Derivados de diazacicloalcanodiona como antagonistas del antigeno asociado a la funcion del linfocito-1 (lfa-1)
US6653478B2 (en) * 2000-10-27 2003-11-25 Ortho-Mcneil Pharmaceutical, Inc. Substituted benzimidazol-2-ones as vasopressin receptor antagonists and neuropeptide Y modulators
GB0028367D0 (en) * 2000-11-21 2001-01-03 Celltech Chiroscience Ltd Chemical compounds
CN1592746A (zh) 2000-11-28 2005-03-09 杰南技术公司 Lfa-1拮抗剂化合物
ATE348829T1 (de) * 2001-02-06 2007-01-15 Pfizer Prod Inc Pharmazeutische zusammensetzungen zur behandlung von störungen des zns oder anderen erkrankungen
AU2002250236A1 (en) * 2001-03-02 2002-09-19 Medimmune, Inc. Cd2 antagonists for treatment of autoimmune or inflammatory disease
US6391290B1 (en) * 2001-03-21 2002-05-21 Schering-Plough Healthcare Products, Inc. Skin care compositions
US6872382B1 (en) * 2001-05-21 2005-03-29 Alcon, Inc. Use of selective PDE IV inhibitors to treat dry eye disorders
IL159203A0 (en) * 2001-06-06 2004-06-01 Aventis Pharma Ltd Substituted tetrahydroisoquinolines for use in the treatment of inflammatory diseases
CA2454618C (en) * 2001-07-24 2012-04-03 Biogen Idec Ma, Inc. Methods for treating or preventing sclerotic disorders using cd2-binding agents
RU26988U1 (ru) 2002-05-06 2003-01-10 Закрытое акционерное общество "ДУКС-ЛИЗИНГ" Кондуктор для сверления отверстий
WO2003103587A2 (en) * 2002-06-06 2003-12-18 Dana-Farber Cancer Institute Compounds or agents that inhibit and induce the formation of focal microvessel dilatations
US7785578B2 (en) * 2002-10-11 2010-08-31 Aciont, Inc. Non-invasive ocular drug delivery
CN1902195B (zh) * 2003-11-05 2016-03-23 萨可德生物科学公司 细胞粘着调节剂
WO2005065668A2 (en) * 2003-12-29 2005-07-21 Qlt Usa, Inc. Topical compositions comprising halo-deoxyadenosines for treatment of skin disorders
EP1756163A2 (en) * 2004-06-09 2007-02-28 Genentech, Inc. Method of treating granuloma annulare or sarcoid
JP2008507552A (ja) * 2004-07-22 2008-03-13 ワイス 神経系障害および状態の治療方法
ES2630406T3 (es) * 2007-10-19 2017-08-21 Sarcode Bioscience Inc. Composición y procedimientos para el tratamiento de la retinopatía diabética
US8080562B2 (en) * 2008-04-15 2011-12-20 Sarcode Bioscience Inc. Crystalline pharmaceutical and methods of preparation and use thereof
WO2011050175A1 (en) * 2009-10-21 2011-04-28 Sarcode Corporation Crystalline pharmaceutical and methods of preparation and use thereof
SI3715345T1 (sl) * 2012-07-25 2024-07-31 Bausch + Lomb Ireland Limited Priprava zaviralca lfa-1

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005044817A1 (en) * 2003-11-05 2005-05-19 Sunesis Pharmaceuticals, Inc. Modulators of cellular adhesion
WO2006125119A1 (en) * 2005-05-17 2006-11-23 Sarcode Corporation Compositions and methods for treatment of eye disorders
JP2011516607A (ja) * 2008-04-15 2011-05-26 サーコード コーポレイション 胃腸系へのlfa−1アンタゴニストの送達
JP2011518155A (ja) * 2008-04-15 2011-06-23 サーコード コーポレイション 免疫関連障害の局所治療に使用するためのエアゾール化lfa−1アンタゴニスト

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2011516607A (ja) * 2008-04-15 2011-05-26 サーコード コーポレイション 胃腸系へのlfa−1アンタゴニストの送達
JP2011518155A (ja) * 2008-04-15 2011-06-23 サーコード コーポレイション 免疫関連障害の局所治療に使用するためのエアゾール化lfa−1アンタゴニスト
JP2020023546A (ja) * 2008-04-15 2020-02-13 サーコード バイオサイエンス インコーポレイテッド 胃腸系へのlfa−1アンタゴニストの送達
JP2022546120A (ja) * 2019-09-03 2022-11-02 スクエア パワー リミテッド セリアック病の予防および治療に使用するためのレバミピド
JP7649296B2 (ja) 2019-09-03 2025-03-19 スクエア パワー リミテッド セリアック病の予防および治療に使用するためのレバミピド含有医薬組成物
WO2024058212A1 (ja) * 2022-09-15 2024-03-21 日油株式会社 コンタクトレンズ用溶液

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