JP2011520898A5 - - Google Patents
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- JP2011520898A5 JP2011520898A5 JP2011509636A JP2011509636A JP2011520898A5 JP 2011520898 A5 JP2011520898 A5 JP 2011520898A5 JP 2011509636 A JP2011509636 A JP 2011509636A JP 2011509636 A JP2011509636 A JP 2011509636A JP 2011520898 A5 JP2011520898 A5 JP 2011520898A5
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- Prior art keywords
- amino acid
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- acid sequence
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- Prior art date
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12740308P | 2008-05-13 | 2008-05-13 | |
| US61/127,403 | 2008-05-13 | ||
| US19415608P | 2008-09-25 | 2008-09-25 | |
| US61/194,156 | 2008-09-25 | ||
| PCT/US2009/043734 WO2009140348A2 (en) | 2008-05-13 | 2009-05-13 | Anti-il-6/il-6r antibodies and methods of use thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015062036A Division JP6195586B2 (ja) | 2008-05-13 | 2015-03-25 | 抗ｉｌ−６／ｉｌ−６ｒ抗体およびそれらの使用方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2011520898A JP2011520898A (ja) | 2011-07-21 |
| JP2011520898A5 true JP2011520898A5 (OSRAM) | 2013-03-14 |
Family
ID=41319307
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011509636A Pending JP2011520898A (ja) | 2008-05-13 | 2009-05-13 | 抗ｉｌ−６／ｉｌ−６ｒ抗体およびそれらの使用方法 |
| JP2015062036A Active JP6195586B2 (ja) | 2008-05-13 | 2015-03-25 | 抗ｉｌ−６／ｉｌ−６ｒ抗体およびそれらの使用方法 |
| JP2017091252A Withdrawn JP2017128613A (ja) | 2008-05-13 | 2017-05-01 | 抗ｉｌ−６／ｉｌ−６ｒ抗体およびそれらの使用方法 |
| JP2020099264A Active JP6923709B2 (ja) | 2008-05-13 | 2020-06-08 | 抗ｉｌ−６／ｉｌ−６ｒ抗体およびそれらの使用方法 |
| JP2021124411A Active JP7297823B2 (ja) | 2008-05-13 | 2021-07-29 | 抗ｉｌ－６／ｉｌ－６ｒ抗体およびそれらの使用方法 |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015062036A Active JP6195586B2 (ja) | 2008-05-13 | 2015-03-25 | 抗ｉｌ−６／ｉｌ−６ｒ抗体およびそれらの使用方法 |
| JP2017091252A Withdrawn JP2017128613A (ja) | 2008-05-13 | 2017-05-01 | 抗ｉｌ−６／ｉｌ−６ｒ抗体およびそれらの使用方法 |
| JP2020099264A Active JP6923709B2 (ja) | 2008-05-13 | 2020-06-08 | 抗ｉｌ−６／ｉｌ−６ｒ抗体およびそれらの使用方法 |
| JP2021124411A Active JP7297823B2 (ja) | 2008-05-13 | 2021-07-29 | 抗ｉｌ－６／ｉｌ－６ｒ抗体およびそれらの使用方法 |
Country Status (11)
| Country | Link |
|---|---|
| US (6) | US8034344B2 (OSRAM) |
| EP (1) | EP2297202B1 (OSRAM) |
| JP (5) | JP2011520898A (OSRAM) |
| CN (1) | CN102089326B (OSRAM) |
| AU (1) | AU2009246430B2 (OSRAM) |
| CA (1) | CA2724279C (OSRAM) |
| DK (1) | DK2297202T3 (OSRAM) |
| ES (1) | ES2564635T3 (OSRAM) |
| IL (1) | IL209277A (OSRAM) |
| MX (1) | MX2010012031A (OSRAM) |
| WO (1) | WO2009140348A2 (OSRAM) |
Families Citing this family (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102006035617A1 (de) * | 2006-07-31 | 2008-02-21 | Siemens Ag | Automatische Bestimmung von Tumorlast |
| TW200831528A (en) | 2006-11-30 | 2008-08-01 | Astrazeneca Ab | Compounds |
| EP3246045B1 (en) * | 2007-07-26 | 2025-09-03 | Osaka University | Therapeutic agents for ocular inflammatory disease comprising interleukin 6 receptor inhibitor as active ingredient |
| CN102089326B (zh) | 2008-05-13 | 2014-12-31 | 诺维莫尼公司 | 抗白细胞介素-6/白细胞介素-6受体的抗体及其使用方法 |
| JP5913103B2 (ja) | 2009-09-14 | 2016-04-27 | ザ リージェンツ オブ ザ ユニバーシティ オブ コロラド，ア ボディー コーポレイトＴＨＥ ＲＥＧＥＮＴＳ ＯＦ ＴＨＥ ＵＮＩＶＥＲＳＩＴＹ ＯＦ ＣＯＬＯＲＡＤＯ，ａ ｂｏｄｙ ｃｏｒｐｏｒａｔｅ | 酵母ベースの免疫療法組成物を含む組合せ物及び被験者のスクリーニング方法 |
| US20120189621A1 (en) | 2011-01-21 | 2012-07-26 | Yann Dean | Combination Therapies and Methods Using Anti-CD3 Modulating Agents and Anti-IL-6 Antagonists |
| MX342810B (es) | 2011-03-03 | 2016-10-13 | Apexigen Inc | Anticuerpos del receptor anti-interleucina-6 (anti-il-6) y sus metodos de uso. |
| WO2013075027A2 (en) * | 2011-11-17 | 2013-05-23 | Emergent Product Development Seattle, Llc | Anti-sil6xr complex binding domains and methods of use |
| KR101510302B1 (ko) | 2012-05-11 | 2015-04-10 | 가톨릭대학교 산학협력단 | Ｉｌ-６ 수용체를 표적으로 하는 항체가 생성되도록 미니서클 벡터를 통해 형질전환된 줄기세포 치료제 |
| US10504132B2 (en) | 2012-11-27 | 2019-12-10 | American Express Travel Related Services Company, Inc. | Dynamic rewards program |
| KR102473544B1 (ko) | 2014-03-17 | 2022-12-01 | 미쓰비시 타나베 파마 코퍼레이션 | 항체-fynomer 접합체 |
| US20170029499A1 (en) | 2015-07-31 | 2017-02-02 | Astrazeneca Pharmaceuticals Lp | Methods for treating hepcidin-mediated disorders |
| MX2018005589A (es) * | 2015-11-03 | 2018-11-09 | Regeneron Pharma | Composiciones que comprenden anticuerpos contra il6r para el tratamiento de la uveitis y el edema macular, y metodos de uso de las mismas. |
| MX2018013523A (es) * | 2016-05-05 | 2019-06-10 | Univ Pennsylvania | Anticuerpos monoclonales de adn dirigidos a il-6 y cd126. |
| AU2017376807B2 (en) | 2016-12-14 | 2024-07-18 | Bt Bidco, Inc. | Treatment of a disease of the gastrointestinal tract with an IL-12/IL-23 inhibitor released using an ingestible device |
| WO2018112237A1 (en) | 2016-12-14 | 2018-06-21 | Progenity Inc. | Treatment of a disease of the gastrointestinal tract with an il-6r inhibitor |
| WO2018112264A1 (en) | 2016-12-14 | 2018-06-21 | Progenity Inc. | Treatment of a disease of the gastrointestinal tract with a chemokine/chemokine receptor inhibitor |
| GB2558223B (en) | 2016-12-22 | 2021-03-31 | Heraeus Electro Nite Int | Method for measuring a temperature of a molten metal bath |
| JP7630906B2 (ja) | 2017-02-01 | 2025-02-18 | イェール・ユニヴァーシティー | 利尿薬耐性の治療 |
| EP3600416B1 (en) | 2017-03-30 | 2023-06-07 | Biora Therapeutics, Inc. | Treatment of a disease of the gastrointestinal tract with an immune modulatory agent released using an ingestible device |
| BR112020004336A2 (pt) | 2017-09-13 | 2020-09-08 | Jiangsu Hengrui Medicine Co., Ltd. | anticorpo il-6r e fragmento de ligação de antígeno do mesmo e uso médico |
| MA51584A (fr) | 2018-01-05 | 2020-11-11 | Corvidia Therapeutics Inc | Méthodes de traitement d'une inflammation médiée par il-6 sans immunosuppression |
| EP3793582A1 (en) * | 2018-05-15 | 2021-03-24 | Erasmus University Medical Center Rotterdam | Treatments and biomarkers for the prognosis of zika virus infection |
| US20230041197A1 (en) | 2018-06-20 | 2023-02-09 | Progenity, Inc. | Treatment of a disease of the gastrointestinal tract with an immunomodulator |
| EP3810268A1 (en) | 2018-06-20 | 2021-04-28 | Progenity, Inc. | Treatment of a disease of the gastrointestinal tract with an il-12/il-23 inhibitor |
| US12227565B2 (en) | 2018-06-20 | 2025-02-18 | Biora Therapeutics, Inc. | Method of formulating a pharmaceutical composition comprising administering an immune modulator to the small intestine |
| CN110055224B (zh) * | 2019-04-03 | 2023-06-30 | 深圳市体内生物医药科技有限公司 | 一种基因修饰的免疫细胞及其制备方法和应用 |
| AU2020261431A1 (en) | 2019-04-24 | 2021-12-09 | Regeneron Pharmaceuticals, Inc. | Methods of diagnosis and treatment of rheumatoid arthritis |
| JP2022534794A (ja) | 2019-06-04 | 2022-08-03 | サノフィ・バイオテクノロジー | 関節リウマチを有する対象における疼痛を治療するための組成物および方法 |
| US20200405883A1 (en) | 2019-06-20 | 2020-12-31 | Baxalta Incorporated | Method of treatment with viral-based gene therapy |
| EP4093767A1 (en) | 2020-01-22 | 2022-11-30 | H. Lee Moffitt Cancer Center & Research Institute, Inc. | Bi-specific chimeric antigen receptor t cells targeting cd83 and interleukin 6 receptor |
| US20210284743A1 (en) | 2020-03-10 | 2021-09-16 | Tiziana Life Sciences Plc | Compositions of il-6/il-6r antibodies and methods of use thereof |
| WO2021207697A1 (en) | 2020-04-10 | 2021-10-14 | Cantex Pharmaceuticals, Inc. | Treatment of acute lung injury |
| CA3175784A1 (en) | 2020-06-17 | 2021-12-23 | Kunwar Shailubhai | Compositions and methods for augmenting chimeric antigen receptor (car) t cell therapies |
| EP4171551A1 (en) | 2020-06-22 | 2023-05-03 | Tranquis Therapeutics, Inc. | Treatment of systemic immune activation syndromes |
| AR122933A1 (es) | 2020-07-10 | 2022-10-19 | Novo Nordisk As | Métodos para tratar la enfermedad cardiovascular |
| WO2022040604A1 (en) | 2020-08-21 | 2022-02-24 | BioAge Labs, Inc. | Use of dp1 receptor antagonists for the treatment of viral respiratory tract infections and dysregulated immune response in aged and aging patients |
| AU2021338354A1 (en) | 2020-09-02 | 2023-04-20 | Serhat GUMRUKCU | Expanded memory subsets of gamma delta T cells for immunotherapy |
| EP4323404A1 (en) | 2021-04-16 | 2024-02-21 | Tiziana Life Sciences PLC | Subcutaneous administration of antibodies for the treatment of disease |
| US20240336679A1 (en) | 2021-08-06 | 2024-10-10 | Institut Regional Du Cancer De Montpellier | Methods for the treatment of cancer |
| WO2024126805A1 (en) | 2022-12-15 | 2024-06-20 | Aarhus Universitet | Synthetic activation of multimeric transmembrane receptors |
Family Cites Families (50)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US6428979B1 (en) | 1988-01-22 | 2002-08-06 | Tadamitsu Kishimoto | Receptor protein for human B cell stimulatory factor-2 |
| CA1341152C (en) | 1988-01-22 | 2000-12-12 | Tadamitsu Kishimoto | Receptor protein for human b cell stimulatory factor-2 |
| US5670373A (en) | 1988-01-22 | 1997-09-23 | Kishimoto; Tadamitsu | Antibody to human interleukin-6 receptor |
| IL88375A (en) | 1988-11-14 | 1995-07-31 | Yeda Res & Dev | Monoclonal antibodies that specifically bind interferon-bia 2 natural and recombinant and a natural and recombinant interferon-beta 2 purification method and method |
| JP2998976B2 (ja) | 1989-07-20 | 2000-01-17 | 忠三 岸本 | ヒトインタ―ロイキン―６レセプターに対する抗体 |
| AU648777B2 (en) | 1989-12-04 | 1994-05-05 | Schering Corporation | Method of treating septic shock |
| US5795965A (en) | 1991-04-25 | 1998-08-18 | Chugai Seiyaku Kabushiki Kaisha | Reshaped human to human interleukin-6 receptor |
| JPH04325095A (ja) | 1991-04-26 | 1992-11-13 | Tosoh Corp | 抗ヒトｉｌ−６モノクロ−ナル抗体及び該抗体を使用するｉｌ−６の測定方法 |
| US5888510A (en) | 1993-07-21 | 1999-03-30 | Chugai Seiyaku Kabushiki Kaisha | Chronic rheumatoid arthritis therapy containing IL-6 antagonist as effective component |
| WO1995009873A1 (en) | 1993-10-06 | 1995-04-13 | Board Of Regents, The University Of Texas System | A monoclonal anti-human il-6 receptor antibody |
| EP0721783B1 (en) | 1994-06-07 | 2005-03-16 | Toray Industries, Inc. | Preventive and remedy for diseases caused by fibrinoid or thrombus formation in the lung |
| EP0783893B1 (en) | 1994-10-07 | 2012-04-04 | Chugai Seiyaku Kabushiki Kaisha | Inhibition of abnormal growth of synovial cells using il-6 antagonist as active ingredient |
| CA2203182C (en) | 1994-10-21 | 2009-11-24 | Asao Katsume | Remedy for diseases caused by il-6 production |
| AU709585B2 (en) * | 1995-09-28 | 1999-09-02 | Yeda Research And Development Co. Ltd. | Synthetic peptides that inhibit IL-6 activity |
| JPH1066582A (ja) | 1996-08-27 | 1998-03-10 | Tosoh Corp | Ｉｌ−６のヘリックスｄ領域を認識する抗体の遺伝子断片等 |
| DK2011514T3 (da) | 1997-03-21 | 2012-03-26 | Chugai Pharmaceutical Co Ltd | Forebyggende eller terapeutisk middel til sensibiliserede-T-celle-medierede sygdomme omfattende IL-6-antagonist som en aktiv bestanddel |
| US20020187150A1 (en) | 1997-08-15 | 2002-12-12 | Chugai Seiyaku Kabushiki Kaisha | Preventive and/or therapeutic agent for systemic lupus erythematosus comprising anti-IL-6 receptor antibody as an active ingredient |
| ES2299241T3 (es) | 1998-03-17 | 2008-05-16 | Chugai Seiyaku Kabushiki Kaisha | Preventivos o remedios para enfermedades intestinales inflamatorias que contienen anticuerpos antagonistas del receptor il-6. |
| US6261250B1 (en) | 1998-08-20 | 2001-07-17 | Rle Corporation | Method and apparatus for enhancing cardiovascular activity and health through rhythmic limb elevation |
| EP1108435B1 (en) | 1998-08-24 | 2007-01-03 | Chugai Seiyaku Kabushiki Kaisha | Preventives or remedies for pancreatitis containing anti-il-6 receptor antibodies as the active ingredient |
| US6419944B2 (en) | 1999-02-24 | 2002-07-16 | Edward L. Tobinick | Cytokine antagonists for the treatment of localized disorders |
| JP4325095B2 (ja) | 2000-09-08 | 2009-09-02 | 株式会社デンソー | ＳｉＣ素子の製造方法 |
| US7320792B2 (en) | 2000-10-25 | 2008-01-22 | Chugai Seiyaku Kabushiki Kaisha | Preventives or remedies for psoriasis containing as the active ingredient IL-6 antagonist |
| AU2000279624A1 (en) | 2000-10-27 | 2002-05-15 | Chugai Seiyaku Kabushiki Kaisha | Blooe vegf level-lowering agent containing il-6 antagonist as the active ingredient |
| AU2000279625A1 (en) | 2000-10-27 | 2002-05-15 | Chugai Seiyaku Kabushiki Kaisha | Blood mmp-3 level-lowering agent containing il-6 antgonist as the active ingredient |
| UA80091C2 (en) | 2001-04-02 | 2007-08-27 | Chugai Pharmaceutical Co Ltd | Remedies for infant chronic arthritis-relating diseases and still's disease which contain an interleukin-6 (il-6) antagonist |
| KR100899357B1 (ko) | 2001-04-27 | 2009-05-26 | 다이셀 가가꾸 고교 가부시끼가이샤 | 다환식구조를 갖는 다당유도체로 이루어지는 분리제 |
| CN100374457C (zh) | 2001-11-14 | 2008-03-12 | 森托科尔公司 | 抗il-6抗体、组合物、方法和用途 |
| CN1678744B (zh) | 2002-08-30 | 2010-05-26 | 财团法人化学及血清疗法研究所 | 人的抗人白细胞介素-6抗体以及所述抗体的片段 |
| HRP20050837A2 (en) | 2003-02-24 | 2005-12-31 | Keio University Chugai Seiyaku Kabushiki Kaisha | Remedy for spinal injury containing interleukin-6 antagonists |
| GB2401040A (en) * | 2003-04-28 | 2004-11-03 | Chugai Pharmaceutical Co Ltd | Method for treating interleukin-6 related diseases |
| TWI503328B (zh) * | 2003-07-15 | 2015-10-11 | Amgen Inc | 作為選擇性神經生長因子（ｎｇｆ）通道抑制劑之人類抗-ｎｇｆ中和抗體 |
| US20050100550A1 (en) | 2003-11-10 | 2005-05-12 | Mohit Trikha | Anti-angiogenic uses of IL-6 antagonists |
| US8617550B2 (en) | 2003-12-19 | 2013-12-31 | Chugai Seiyaku Kabushiki Kaisha | Treatment of vasculitis with IL-6 antagonist |
| ES2341461T5 (es) | 2004-02-11 | 2014-10-29 | Warner-Lambert Company Llc | Procedimientos de tratamiento de la artrosis con anticuerpos ANTI-IL-6 |
| AR048335A1 (es) | 2004-03-24 | 2006-04-19 | Chugai Pharmaceutical Co Ltd | Agentes terapeuticos para trastornos del oido interno que contienen un antagonista de il- 6 como un ingrediente activo |
| US20070036788A1 (en) | 2004-09-22 | 2007-02-15 | Ahmed Sheriff | Use of a compound for reducing the biological effectiveness of il-6 |
| KR100595113B1 (ko) | 2005-03-07 | 2006-06-30 | 삼성에스디아이 주식회사 | 펌프 진동 및 소음 방지 구조가 구비된 연료 전지 시스템 |
| PE20061324A1 (es) | 2005-04-29 | 2007-01-15 | Centocor Inc | Anticuerpos anti-il-6, composiciones, metodos y usos |
| ZA200804594B (en) | 2005-12-09 | 2010-08-25 | Ucb Pharma Sa | Antibody molecules having specificity for human IL-6 |
| BRPI0620797A2 (pt) * | 2005-12-30 | 2011-11-22 | Merck Patent Ges Mit Beschonkter Haftung | anticorpos anti-il-6 que previnem a ligação de il-6 complexado com il-6ralfa a gp130 |
| PL2374818T3 (pl) | 2006-06-02 | 2013-05-31 | Regeneron Pharma | Przeciwciała o wysokim powinowactwie przeciw ludzkiemu receptorowi IL 6 |
| JP4743037B2 (ja) | 2006-07-28 | 2011-08-10 | 株式会社デンソー | 車両検出装置 |
| EP2064241B1 (en) | 2006-08-03 | 2015-10-07 | Vaccinex, Inc. | Anti-il-6 monoclonal antibodies and uses thereof |
| EP2068889B1 (en) | 2006-08-10 | 2019-10-23 | Roy C. Levitt | Anakinra for use in the treatment of bronchiolitis obliterans syndrome |
| CA2670583A1 (en) * | 2006-11-30 | 2008-06-05 | Medimmune, Llc | Antibodies specific for the complex of interleukin-6 and the interleukin-6 receptor |
| TW200831528A (en) | 2006-11-30 | 2008-08-01 | Astrazeneca Ab | Compounds |
| CA2672386A1 (en) | 2006-12-13 | 2008-06-19 | Ablynx N.V. | Polypeptides specific for complexes involved in receptor-mediated signaling, such as the il-6/il-6 receptor complex |
| TWI363414B (en) | 2007-01-29 | 2012-05-01 | Touch Micro System Tech | Interposer for connecting a plurality of chips and method for manufacturing the same |
| CN102089326B (zh) | 2008-05-13 | 2014-12-31 | 诺维莫尼公司 | 抗白细胞介素-6/白细胞介素-6受体的抗体及其使用方法 |
-
2009
- 2009-05-13 CN CN200980127494.7A patent/CN102089326B/zh active Active
- 2009-05-13 EP EP09747432.4A patent/EP2297202B1/en active Active
- 2009-05-13 WO PCT/US2009/043734 patent/WO2009140348A2/en not_active Ceased
- 2009-05-13 CA CA2724279A patent/CA2724279C/en active Active
- 2009-05-13 US US12/465,295 patent/US8034344B2/en active Active
- 2009-05-13 JP JP2011509636A patent/JP2011520898A/ja active Pending
- 2009-05-13 ES ES09747432.4T patent/ES2564635T3/es active Active
- 2009-05-13 DK DK09747432.4T patent/DK2297202T3/en active
- 2009-05-13 AU AU2009246430A patent/AU2009246430B2/en active Active
- 2009-05-13 MX MX2010012031A patent/MX2010012031A/es active IP Right Grant
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2010
- 2010-11-11 IL IL209277A patent/IL209277A/en active IP Right Grant
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2011
- 2011-09-07 US US13/227,157 patent/US8337849B2/en active Active
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2012
- 2012-12-21 US US13/723,694 patent/US9234034B2/en active Active
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2015
- 2015-03-25 JP JP2015062036A patent/JP6195586B2/ja active Active
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2016
- 2016-01-12 US US14/993,153 patent/US9828430B2/en active Active
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2017
- 2017-05-01 JP JP2017091252A patent/JP2017128613A/ja not_active Withdrawn
- 2017-11-27 US US15/823,086 patent/US10759862B2/en active Active
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2020
- 2020-06-08 JP JP2020099264A patent/JP6923709B2/ja active Active
- 2020-07-31 US US16/944,828 patent/US11613582B2/en active Active
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2021
- 2021-07-29 JP JP2021124411A patent/JP7297823B2/ja active Active
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