JP2017505622A5 - - Google Patents
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- Publication number
- JP2017505622A5 JP2017505622A5 JP2016549322A JP2016549322A JP2017505622A5 JP 2017505622 A5 JP2017505622 A5 JP 2017505622A5 JP 2016549322 A JP2016549322 A JP 2016549322A JP 2016549322 A JP2016549322 A JP 2016549322A JP 2017505622 A5 JP2017505622 A5 JP 2017505622A5
- Authority
- JP
- Japan
- Prior art keywords
- baff
- seq
- antibody molecule
- chain variable
- variable domain
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 101710181056 Tumor necrosis factor ligand superfamily member 13B Proteins 0.000 claims 8
- 102100036922 Tumor necrosis factor ligand superfamily member 13B Human genes 0.000 claims 8
- 125000003275 alpha amino acid group Chemical group 0.000 claims 6
- 238000000034 method Methods 0.000 claims 5
- 102000007536 B-Cell Activation Factor Receptor Human genes 0.000 claims 3
- 108010046304 B-Cell Activation Factor Receptor Proteins 0.000 claims 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- 102000006942 B-Cell Maturation Antigen Human genes 0.000 claims 2
- 108010008014 B-Cell Maturation Antigen Proteins 0.000 claims 2
- 101000851434 Homo sapiens Tumor necrosis factor ligand superfamily member 13B Proteins 0.000 claims 2
- 102100029690 Tumor necrosis factor receptor superfamily member 13C Human genes 0.000 claims 2
- 101710178300 Tumor necrosis factor receptor superfamily member 13C Proteins 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 102000050326 human TNFSF13B Human genes 0.000 claims 2
- 230000002401 inhibitory effect Effects 0.000 claims 2
- 239000012528 membrane Substances 0.000 claims 2
- 102000040430 polynucleotide Human genes 0.000 claims 2
- 108091033319 polynucleotide Proteins 0.000 claims 2
- 239000002157 polynucleotide Substances 0.000 claims 2
- 208000023275 Autoimmune disease Diseases 0.000 claims 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims 1
- 108010072220 Cyclophilin A Proteins 0.000 claims 1
- 208000005777 Lupus Nephritis Diseases 0.000 claims 1
- 241001465754 Metazoa Species 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 102100034539 Peptidyl-prolyl cis-trans isomerase A Human genes 0.000 claims 1
- 239000012190 activator Substances 0.000 claims 1
- 229910052791 calcium Inorganic materials 0.000 claims 1
- 239000011575 calcium Substances 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 210000004027 cell Anatomy 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 208000027866 inflammatory disease Diseases 0.000 claims 1
- 239000003446 ligand Substances 0.000 claims 1
- 210000004962 mammalian cell Anatomy 0.000 claims 1
- 230000001404 mediated effect Effects 0.000 claims 1
- 208000030159 metabolic disease Diseases 0.000 claims 1
- 208000023504 respiratory system disease Diseases 0.000 claims 1
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 1
- 230000011664 signaling Effects 0.000 claims 1
- 201000000596 systemic lupus erythematosus Diseases 0.000 claims 1
- 239000013638 trimer Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461934124P | 2014-01-31 | 2014-01-31 | |
| US61/934,124 | 2014-01-31 | ||
| PCT/US2015/013711 WO2016039801A1 (en) | 2014-01-31 | 2015-01-30 | Novel anti-baff antibodies |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017505622A JP2017505622A (ja) | 2017-02-23 |
| JP2017505622A5 true JP2017505622A5 (OSRAM) | 2018-03-08 |
| JP6511459B2 JP6511459B2 (ja) | 2019-05-15 |
Family
ID=53754266
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016549322A Active JP6511459B2 (ja) | 2014-01-31 | 2015-01-30 | 新規な抗ｂａｆｆ抗体 |
Country Status (14)
| Country | Link |
|---|---|
| US (3) | US9840543B2 (OSRAM) |
| EP (1) | EP3099715B1 (OSRAM) |
| JP (1) | JP6511459B2 (OSRAM) |
| KR (1) | KR20160113715A (OSRAM) |
| CN (1) | CN105873949B (OSRAM) |
| AU (1) | AU2015315834B2 (OSRAM) |
| BR (1) | BR112016014731A2 (OSRAM) |
| CA (1) | CA2934965A1 (OSRAM) |
| CL (1) | CL2016001742A1 (OSRAM) |
| EA (1) | EA033604B1 (OSRAM) |
| IL (2) | IL246113B (OSRAM) |
| MX (1) | MX367661B (OSRAM) |
| PH (1) | PH12016501366A1 (OSRAM) |
| WO (1) | WO2016039801A1 (OSRAM) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9458246B2 (en) | 2013-03-13 | 2016-10-04 | Amgen Inc. | Proteins specific for BAFF and B7RP1 |
| PH12022550138A1 (en) | 2013-03-13 | 2023-03-06 | Amgen Inc | Proteins specific for baff and b7rp1 and uses thereof |
| EA033604B1 (ru) | 2014-01-31 | 2019-11-08 | Boehringer Ingelheim Int | Молекула анти-baff антитела, фармацевтическая композиция, содержащая эту молекулу, способы ее применения и кодирующий ее изолированный полинуклеотид |
| KR102644875B1 (ko) * | 2015-07-23 | 2024-03-06 | 베링거잉겔하임인터내쇼날유한회사 | Il-23a 및 b-세포 활성화 인자(baff)를 표적화하는 화합물 및 이의 용도 |
| WO2017223534A2 (en) * | 2016-06-24 | 2017-12-28 | Anthera Pharmaceuticals, Inc. | Methods of treating iga nephropathy and henoch-schönlein purpura nephritis using a b-cell activating factor (baff) inhibitor |
| JP2019533423A (ja) * | 2016-07-06 | 2019-11-21 | シャンハイ ファーマエクスプローラー カンパニー，リミティド | ＢＬｙＳ抗体及びその製造方法と応用 |
| US10869522B2 (en) | 2016-11-04 | 2020-12-22 | Totes Isotoner Corporation | Footwear, and methods of preparing same |
| EP3824906A1 (en) | 2016-12-21 | 2021-05-26 | Amgen Inc. | Anti-tnf alpha antibody formulations |
| EP3735272A4 (en) * | 2018-01-05 | 2021-09-22 | Biograph 55, Inc. | COMPOSITIONS AND METHODS FOR IMMUNO CANCEROTHERAPY |
| CA3096222A1 (en) | 2018-04-06 | 2019-10-10 | Atyr Pharma, Inc. | Compositions and methods comprising anti-nrp2 antibodies |
| US20210238295A1 (en) * | 2018-04-26 | 2021-08-05 | University Of Virginia Patent Foundation | Compositions and methods for treating abdominal aortic aneurysm |
| CN114746120B (zh) | 2019-10-03 | 2024-07-30 | Atyr医药公司 | 包含抗nrp2抗体的组合物和方法 |
| WO2021188631A1 (en) * | 2020-03-18 | 2021-09-23 | Kindred Biosciences, Inc. | Anti-il4 receptor antibodies for veterinary use |
| CN113637073B (zh) * | 2020-05-11 | 2024-04-12 | 上海赛比曼生物科技有限公司 | Bcma抗体及其制备和应用 |
| CN116390933A (zh) | 2020-11-06 | 2023-07-04 | 诺华股份有限公司 | 治疗b细胞恶性肿瘤的抗cd19剂和b细胞靶向剂组合疗法 |
| CN112516303A (zh) * | 2020-11-18 | 2021-03-19 | 华中科技大学同济医学院附属协和医院 | Baff抗体在制备脓毒血症药物中的应用 |
| CN116178530A (zh) * | 2021-09-26 | 2023-05-30 | 上海君实生物医药科技股份有限公司 | 抗体在治疗SARS-CoV-2感染的用途 |
| CN118440195B (zh) * | 2022-06-17 | 2025-04-08 | 东莞市朋志生物科技有限公司 | 抗脂联素抗体、检测脂联素的试剂和试剂盒 |
| WO2024197157A1 (en) | 2023-03-21 | 2024-09-26 | Biograph 55, Inc. | Cd19/cd38 multispecific antibodies |
| WO2025125137A1 (en) * | 2023-12-11 | 2025-06-19 | Glaxosmithkline Intellectual Property Development Limited | Baff specific antibodies |
| WO2025149667A1 (en) | 2024-01-12 | 2025-07-17 | Pheon Therapeutics Ltd | Antibody drug conjugates and uses thereof |
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| US4179337A (en) | 1973-07-20 | 1979-12-18 | Davis Frank F | Non-immunogenic polypeptides |
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| US4419446A (en) | 1980-12-31 | 1983-12-06 | The United States Of America As Represented By The Department Of Health And Human Services | Recombinant DNA process utilizing a papilloma virus DNA as a vector |
| US4485045A (en) | 1981-07-06 | 1984-11-27 | Research Corporation | Synthetic phosphatidyl cholines useful in forming liposomes |
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| US4560655A (en) | 1982-12-16 | 1985-12-24 | Immunex Corporation | Serum-free cell culture medium and process for making same |
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| RU2751240C2 (ru) | 2011-10-28 | 2021-07-12 | Регенерон Фармасьютикалс, Инк. | Гуманизированные il-6 и рецептор il-6 |
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| US9458246B2 (en) | 2013-03-13 | 2016-10-04 | Amgen Inc. | Proteins specific for BAFF and B7RP1 |
| EA033604B1 (ru) * | 2014-01-31 | 2019-11-08 | Boehringer Ingelheim Int | Молекула анти-baff антитела, фармацевтическая композиция, содержащая эту молекулу, способы ее применения и кодирующий ее изолированный полинуклеотид |
-
2015
- 2015-01-30 EA EA201691541A patent/EA033604B1/ru not_active IP Right Cessation
- 2015-01-30 WO PCT/US2015/013711 patent/WO2016039801A1/en not_active Ceased
- 2015-01-30 MX MX2016009877A patent/MX367661B/es active IP Right Grant
- 2015-01-30 EP EP15703426.5A patent/EP3099715B1/en active Active
- 2015-01-30 JP JP2016549322A patent/JP6511459B2/ja active Active
- 2015-01-30 CA CA2934965A patent/CA2934965A1/en not_active Abandoned
- 2015-01-30 AU AU2015315834A patent/AU2015315834B2/en not_active Ceased
- 2015-01-30 CN CN201580003487.1A patent/CN105873949B/zh active Active
- 2015-01-30 KR KR1020167023947A patent/KR20160113715A/ko not_active Withdrawn
- 2015-01-30 US US14/609,756 patent/US9840543B2/en active Active
- 2015-01-30 BR BR112016014731A patent/BR112016014731A2/pt not_active Application Discontinuation
-
2016
- 2016-06-08 IL IL246113A patent/IL246113B/en not_active IP Right Cessation
- 2016-07-07 CL CL2016001742A patent/CL2016001742A1/es unknown
- 2016-07-11 PH PH12016501366A patent/PH12016501366A1/en unknown
-
2017
- 2017-11-06 US US15/803,993 patent/US10377804B2/en active Active
-
2019
- 2019-05-26 IL IL266864A patent/IL266864A/en unknown
- 2019-06-25 US US16/451,333 patent/US11370818B2/en active Active
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