CN116041515A - 一种靶向baff-r抗原的全人源抗体、单链抗体、抗原结合片段 - Google Patents
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- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
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- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
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- C—CHEMISTRY; METALLURGY
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- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
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- C07K2317/565—Complementarity determining region [CDR]
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- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
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- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
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Abstract
Description
分析物 | KD(M) | kon(1/Ms) | kdis(1/s) |
Clone 1 IgG | 3.35E-09 | 3.54E+05 | 1.19E-03 |
Clone 4 IgG | 2.27E-09 | 4.25E+05 | 9.66E-04 |
Clone 10 IgG | 7.62E-10 | 1.14E+05 | 8.72E-05 |
Clone 14 IgG | 3.30E-09 | 1.86E+05 | 6.14E-04 |
Clone 22 IgG | 6.42E-09 | 4.81E+05 | 3.09E-03 |
Claims (15)
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CN202211146308.8A CN116041515A (zh) | 2022-09-20 | 2022-09-20 | 一种靶向baff-r抗原的全人源抗体、单链抗体、抗原结合片段 |
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CN202211146308.8A CN116041515A (zh) | 2022-09-20 | 2022-09-20 | 一种靶向baff-r抗原的全人源抗体、单链抗体、抗原结合片段 |
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CN116041515A true CN116041515A (zh) | 2023-05-02 |
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CN202211146308.8A Pending CN116041515A (zh) | 2022-09-20 | 2022-09-20 | 一种靶向baff-r抗原的全人源抗体、单链抗体、抗原结合片段 |
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CN (1) | CN116041515A (zh) |
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