JP2011520883A5 - - Google Patents
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- Publication number
- JP2011520883A5 JP2011520883A5 JP2011509539A JP2011509539A JP2011520883A5 JP 2011520883 A5 JP2011520883 A5 JP 2011520883A5 JP 2011509539 A JP2011509539 A JP 2011509539A JP 2011509539 A JP2011509539 A JP 2011509539A JP 2011520883 A5 JP2011520883 A5 JP 2011520883A5
- Authority
- JP
- Japan
- Prior art keywords
- emulsion
- pharmaceutical composition
- fentanyl
- composition according
- kit
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000839 emulsion Substances 0.000 claims 25
- PJMPHNIQZUBGLI-UHFFFAOYSA-N fentanyl Chemical compound C=1C=CC=CC=1N(C(=O)CC)C(CC1)CCN1CCC1=CC=CC=C1 PJMPHNIQZUBGLI-UHFFFAOYSA-N 0.000 claims 13
- 239000008194 pharmaceutical composition Substances 0.000 claims 12
- 229960002428 fentanyl Drugs 0.000 claims 7
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims 6
- 238000004945 emulsification Methods 0.000 claims 6
- 239000003925 fat Substances 0.000 claims 6
- 229960004207 fentanyl citrate Drugs 0.000 claims 6
- IVLVTNPOHDFFCJ-UHFFFAOYSA-N fentanyl citrate Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O.C=1C=CC=CC=1N(C(=O)CC)C(CC1)CCN1CCC1=CC=CC=C1 IVLVTNPOHDFFCJ-UHFFFAOYSA-N 0.000 claims 6
- 238000009472 formulation Methods 0.000 claims 6
- 238000002347 injection Methods 0.000 claims 6
- 239000007924 injection Substances 0.000 claims 6
- 239000000203 mixture Substances 0.000 claims 6
- 239000004094 surface-active agent Substances 0.000 claims 6
- WRIDQFICGBMAFQ-UHFFFAOYSA-N (E)-8-Octadecenoic acid Natural products CCCCCCCCCC=CCCCCCCC(O)=O WRIDQFICGBMAFQ-UHFFFAOYSA-N 0.000 claims 3
- JLPULHDHAOZNQI-ZTIMHPMXSA-N 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCC\C=C/C\C=C/CCCCC JLPULHDHAOZNQI-ZTIMHPMXSA-N 0.000 claims 3
- LQJBNNIYVWPHFW-UHFFFAOYSA-N 20:1omega9c fatty acid Natural products CCCCCCCCCCC=CCCCCCCCC(O)=O LQJBNNIYVWPHFW-UHFFFAOYSA-N 0.000 claims 3
- QSBYPNXLFMSGKH-UHFFFAOYSA-N 9-Heptadecensaeure Natural products CCCCCCCC=CCCCCCCCC(O)=O QSBYPNXLFMSGKH-UHFFFAOYSA-N 0.000 claims 3
- ZQPPMHVWECSIRJ-UHFFFAOYSA-N Oleic acid Natural products CCCCCCCCC=CCCCCCCCC(O)=O ZQPPMHVWECSIRJ-UHFFFAOYSA-N 0.000 claims 3
- 239000005642 Oleic acid Substances 0.000 claims 3
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims 3
- 210000003169 central nervous system Anatomy 0.000 claims 3
- 230000001609 comparable effect Effects 0.000 claims 3
- 230000000694 effects Effects 0.000 claims 3
- 239000008344 egg yolk phospholipid Substances 0.000 claims 3
- 229940068998 egg yolk phospholipid Drugs 0.000 claims 3
- 235000011187 glycerol Nutrition 0.000 claims 3
- QXJSBBXBKPUZAA-UHFFFAOYSA-N isooleic acid Natural products CCCCCCCC=CCCCCCCCCC(O)=O QXJSBBXBKPUZAA-UHFFFAOYSA-N 0.000 claims 3
- 230000001404 mediated effect Effects 0.000 claims 3
- 239000003921 oil Substances 0.000 claims 3
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid group Chemical group C(CCCCCCC\C=C/CCCCCCCC)(=O)O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 claims 3
- 239000008347 soybean phospholipid Substances 0.000 claims 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 3
- 230000003533 narcotic effect Effects 0.000 claims 2
- 208000004550 Postoperative Pain Diseases 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US5357108P | 2008-05-15 | 2008-05-15 | |
| US61/053,571 | 2008-05-15 | ||
| US12/424,382 | 2009-04-15 | ||
| US12/424,382 US20090286832A1 (en) | 2008-05-15 | 2009-04-15 | Narcotic emulsion formulations for treatment of surgical pain |
| PCT/US2009/041991 WO2009140059A2 (en) | 2008-05-15 | 2009-04-28 | Narcotic emulsion formulations for treatment of surgical pain |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014107385A Division JP5889364B2 (ja) | 2008-05-15 | 2014-05-23 | 手術痛の治療のための麻薬性乳剤 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011520883A JP2011520883A (ja) | 2011-07-21 |
| JP2011520883A5 true JP2011520883A5 (https=) | 2011-11-10 |
| JP5689053B2 JP5689053B2 (ja) | 2015-03-25 |
Family
ID=41316744
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011509539A Expired - Fee Related JP5689053B2 (ja) | 2008-05-15 | 2009-04-28 | 手術痛の治療のための麻薬性乳剤 |
| JP2014107385A Expired - Fee Related JP5889364B2 (ja) | 2008-05-15 | 2014-05-23 | 手術痛の治療のための麻薬性乳剤 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014107385A Expired - Fee Related JP5889364B2 (ja) | 2008-05-15 | 2014-05-23 | 手術痛の治療のための麻薬性乳剤 |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US20090286832A1 (https=) |
| EP (1) | EP2276440A4 (https=) |
| JP (2) | JP5689053B2 (https=) |
| KR (1) | KR101361479B1 (https=) |
| CN (1) | CN101938963A (https=) |
| AR (1) | AR071779A1 (https=) |
| AU (1) | AU2009246713B2 (https=) |
| BR (1) | BRPI0907224A2 (https=) |
| CA (1) | CA2710546A1 (https=) |
| EA (1) | EA201000991A1 (https=) |
| IL (1) | IL209145A0 (https=) |
| MX (1) | MX2010007698A (https=) |
| NZ (1) | NZ586461A (https=) |
| TW (2) | TW201406403A (https=) |
| WO (1) | WO2009140059A2 (https=) |
| ZA (1) | ZA201004392B (https=) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20090286832A1 (en) * | 2008-05-15 | 2009-11-19 | Kiichiro Nabeta | Narcotic emulsion formulations for treatment of surgical pain |
| EA201190135A1 (ru) * | 2009-02-26 | 2012-07-30 | ТЕЙКОКУ ФАРМА ЮЭсЭй, ИНК. | Композиции на основе эмульгированных наркотических веществ для лечения боли при раке |
| JP6081240B2 (ja) * | 2013-03-13 | 2017-02-15 | テルモ株式会社 | レミフェンタニル注射液剤 |
| WO2016038734A1 (ja) | 2014-09-12 | 2016-03-17 | テルモ株式会社 | レミフェンタニル注射液剤 |
| WO2021252449A1 (en) * | 2020-06-08 | 2021-12-16 | Harm Reduction Therapeutics, Inc. | Sterilized formulations |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0647533B2 (ja) * | 1984-08-10 | 1994-06-22 | 裕 水島 | ４−ビフエニリル酢酸系化合物含有脂肪乳剤 |
| US4816247A (en) * | 1985-09-11 | 1989-03-28 | American Cyanamid Company | Emulsion compositions for administration of sparingly water soluble ionizable hydrophobic drugs |
| DE69511418T2 (de) * | 1995-10-28 | 2000-03-30 | B. Braun Melsungen Ag | Lokalanästhetika und/oder Zentralanalgetika enthaltende pharmazeutische Zusammensetzungen |
| GB9721746D0 (en) * | 1997-10-15 | 1997-12-10 | Panos Therapeutics Limited | Compositions |
| US6835194B2 (en) * | 1999-03-18 | 2004-12-28 | Durect Corporation | Implantable devices and methods for treatment of pain by delivery of fentanyl and fentanyl congeners |
| US6541021B1 (en) * | 1999-03-18 | 2003-04-01 | Durect Corporation | Devices and methods for pain management |
| US6455525B1 (en) * | 1999-11-04 | 2002-09-24 | Cephalon, Inc. | Heterocyclic substituted pyrazolones |
| KR100921199B1 (ko) * | 2001-05-11 | 2009-10-13 | 미쓰비시 타나베 파마 코퍼레이션 | 안정하고 고농도인 피라졸론 유도체를 포함하는 주사제 |
| NZ534012A (en) * | 2002-01-25 | 2006-12-22 | Theravance Inc | Substituted phenylacetic acid ester compounds as short-acting sedative hypnotic agents for anesthesia and sedation |
| JP2004043479A (ja) * | 2002-07-11 | 2004-02-12 | Taiho Yakuhin Kogyo Kk | 経鼻吸収用組成物 |
| ZA200502612B (en) * | 2002-10-08 | 2007-07-25 | Rinat Neuroscience Corp | Methods for treating post-surgical pain by administering a nerve crowth factor antagonist and compositions containing the same |
| UA80447C2 (en) * | 2002-10-08 | 2007-09-25 | Methods for treating pain by administering nerve growth factor antagonist and opioid analgesic | |
| US7648982B2 (en) * | 2003-02-28 | 2010-01-19 | Ym Biosciences Inc. | Opioid delivery system |
| JP2004275852A (ja) * | 2003-03-14 | 2004-10-07 | Mitsubishi Heavy Ind Ltd | 排煙脱硝触媒及びその製造方法 |
| US20060111382A1 (en) * | 2004-05-17 | 2006-05-25 | Pharmacofore, Inc. | Compositions and methods for treating or preventing pain |
| DE102004025357B4 (de) * | 2004-05-19 | 2007-03-29 | Beiersdorf Ag | Emulsionskonzentrat mit wasserlöslichen und öllöslichen Polymeren und kosmetische Zubereitung enthaltend Emulsionskonzentrat sowie ein Verfahren zu dessen Herstellung und dessen Verwendung |
| US7871632B2 (en) * | 2004-07-12 | 2011-01-18 | Adventrx Pharmaceuticals, Inc. | Compositions for delivering highly water soluble drugs |
| US20060189682A1 (en) * | 2005-02-02 | 2006-08-24 | Payne Joseph E | Water soluble prodrugs of COX-2 inhibitors |
| WO2006098241A1 (ja) * | 2005-03-14 | 2006-09-21 | Otsuka Pharmaceutical Factory, Inc. | 難水溶性薬物を含有する医薬組成物 |
| CA2608111A1 (en) * | 2005-04-22 | 2006-11-02 | Novacardia, Inc. | Production of emulsions for intravenous injection of water-insoluble pharmaceutical compositions |
| US8158152B2 (en) * | 2005-11-18 | 2012-04-17 | Scidose Llc | Lyophilization process and products obtained thereby |
| US8252328B2 (en) * | 2006-01-06 | 2012-08-28 | Acelrx Pharmaceuticals, Inc. | Bioadhesive drug formulations for oral transmucosal delivery |
| ES2535233T3 (es) * | 2006-01-25 | 2015-05-06 | Insys Therapeutics, Inc. | Pulverización de fentanilo sublingual |
| US20090286832A1 (en) * | 2008-05-15 | 2009-11-19 | Kiichiro Nabeta | Narcotic emulsion formulations for treatment of surgical pain |
| EA201190135A1 (ru) * | 2009-02-26 | 2012-07-30 | ТЕЙКОКУ ФАРМА ЮЭсЭй, ИНК. | Композиции на основе эмульгированных наркотических веществ для лечения боли при раке |
-
2009
- 2009-04-15 US US12/424,382 patent/US20090286832A1/en not_active Abandoned
- 2009-04-28 KR KR1020107015502A patent/KR101361479B1/ko not_active Expired - Fee Related
- 2009-04-28 CA CA2710546A patent/CA2710546A1/en not_active Abandoned
- 2009-04-28 WO PCT/US2009/041991 patent/WO2009140059A2/en not_active Ceased
- 2009-04-28 BR BRPI0907224-1A patent/BRPI0907224A2/pt not_active IP Right Cessation
- 2009-04-28 JP JP2011509539A patent/JP5689053B2/ja not_active Expired - Fee Related
- 2009-04-28 AU AU2009246713A patent/AU2009246713B2/en not_active Ceased
- 2009-04-28 NZ NZ586461A patent/NZ586461A/en not_active IP Right Cessation
- 2009-04-28 EP EP09747145A patent/EP2276440A4/en not_active Withdrawn
- 2009-04-28 MX MX2010007698A patent/MX2010007698A/es not_active Application Discontinuation
- 2009-04-28 EA EA201000991A patent/EA201000991A1/ru unknown
- 2009-04-28 CN CN2009801021888A patent/CN101938963A/zh active Pending
- 2009-05-13 AR ARP090101725A patent/AR071779A1/es not_active Application Discontinuation
- 2009-05-14 TW TW102123473A patent/TW201406403A/zh unknown
- 2009-05-14 TW TW098115948A patent/TWI413531B/zh not_active IP Right Cessation
-
2010
- 2010-06-22 ZA ZA2010/04392A patent/ZA201004392B/en unknown
- 2010-11-04 IL IL209145A patent/IL209145A0/en unknown
-
2014
- 2014-05-23 JP JP2014107385A patent/JP5889364B2/ja not_active Expired - Fee Related
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