JP2011520785A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2011520785A5 JP2011520785A5 JP2011504523A JP2011504523A JP2011520785A5 JP 2011520785 A5 JP2011520785 A5 JP 2011520785A5 JP 2011504523 A JP2011504523 A JP 2011504523A JP 2011504523 A JP2011504523 A JP 2011504523A JP 2011520785 A5 JP2011520785 A5 JP 2011520785A5
- Authority
- JP
- Japan
- Prior art keywords
- independently
- optionally
- substituted
- substituents
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 125000001424 substituent group Chemical group 0.000 claims 39
- 125000000217 alkyl group Chemical group 0.000 claims 13
- 125000005843 halogen group Chemical group 0.000 claims 13
- 229910052739 hydrogen Inorganic materials 0.000 claims 12
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 10
- 239000001257 hydrogen Substances 0.000 claims 10
- 125000003118 aryl group Chemical group 0.000 claims 8
- 125000001072 heteroaryl group Chemical group 0.000 claims 8
- 125000004429 atom Chemical group 0.000 claims 7
- 125000004093 cyano group Chemical group *C#N 0.000 claims 7
- 125000005842 heteroatom Chemical group 0.000 claims 7
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims 6
- 125000001153 fluoro group Chemical group F* 0.000 claims 5
- 229910052757 nitrogen Inorganic materials 0.000 claims 5
- 125000004209 (C1-C8) alkyl group Chemical group 0.000 claims 4
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 4
- 125000001309 chloro group Chemical group Cl* 0.000 claims 4
- 125000006850 spacer group Chemical group 0.000 claims 4
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 3
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 2
- 229910052760 oxygen Inorganic materials 0.000 claims 2
- 239000001301 oxygen Substances 0.000 claims 2
- 125000003161 (C1-C6) alkylene group Chemical group 0.000 claims 1
- 230000015572 biosynthetic process Effects 0.000 claims 1
- 229910052799 carbon Inorganic materials 0.000 claims 1
- 125000004432 carbon atom Chemical group C* 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 230000005764 inhibitory process Effects 0.000 claims 1
- GWNVDXQDILPJIG-NXOLIXFESA-N leukotriene C4 Chemical compound CCCCC\C=C/C\C=C/C=C/C=C/[C@H]([C@@H](O)CCCC(O)=O)SC[C@@H](C(=O)NCC(O)=O)NC(=O)CC[C@H](N)C(O)=O GWNVDXQDILPJIG-NXOLIXFESA-N 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 238000003786 synthesis reaction Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US7117608P | 2008-04-16 | 2008-04-16 | |
| US61/071,176 | 2008-04-16 | ||
| PCT/GB2009/000966 WO2009127822A2 (en) | 2008-04-16 | 2009-04-16 | Bis-aryl compounds for use as medicaments |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2011520785A JP2011520785A (ja) | 2011-07-21 |
| JP2011520785A5 true JP2011520785A5 (enExample) | 2012-06-07 |
Family
ID=40897329
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011504523A Withdrawn JP2011520785A (ja) | 2008-04-16 | 2009-04-16 | 薬剤としての使用のためのビスアリール化合物 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20110071197A1 (enExample) |
| EP (1) | EP2274280A2 (enExample) |
| JP (1) | JP2011520785A (enExample) |
| CN (1) | CN102036952A (enExample) |
| CA (1) | CA2721452A1 (enExample) |
| WO (1) | WO2009127822A2 (enExample) |
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8563573B2 (en) | 2007-11-02 | 2013-10-22 | Vertex Pharmaceuticals Incorporated | Azaindole derivatives as CFTR modulators |
| US8377992B2 (en) * | 2007-10-22 | 2013-02-19 | The Wistar Institute | TRBD-binding effectors and methods for using the same to modulate telomerase activity |
| US9273077B2 (en) | 2008-05-21 | 2016-03-01 | Ariad Pharmaceuticals, Inc. | Phosphorus derivatives as kinase inhibitors |
| PT2300013T (pt) | 2008-05-21 | 2017-10-31 | Ariad Pharma Inc | Derivados de fósforo como inibidores de cinases |
| HRP20150355T1 (hr) | 2009-01-12 | 2015-06-19 | Pfizer Limited | Sulfonamidni derivati |
| AR080375A1 (es) | 2010-03-05 | 2012-04-04 | Sanofi Aventis | Procedimiento para la preparacion de 2-(cicloheximetil)-n-{2-[(2s)-1-metilpirrolidin-2-il] etil}-1,2,3,4-tetrahidroisoquinolina- 7-sulfonamida |
| US8802868B2 (en) | 2010-03-25 | 2014-08-12 | Vertex Pharmaceuticals Incorporated | Solid forms of (R)-1(2,2-difluorobenzo[D][1,3]dioxo1-5-yl)-N-(1-(2,3-dihydroxypropyl-6-fluoro-2-(1-hydroxy-2-methylpropan2-yl)-1H-Indol-5-yl)-Cyclopropanecarboxamide |
| RU2569678C2 (ru) | 2010-04-22 | 2015-11-27 | Вертекс Фармасьютикалз Инкорпорейтед | Способ получения циклоалкилкарбоксамидо-индольных соединений |
| US9145407B2 (en) | 2010-07-09 | 2015-09-29 | Pfizer Limited | Sulfonamide compounds |
| EP2704572B1 (en) | 2011-05-04 | 2015-12-30 | Ariad Pharmaceuticals, Inc. | Compounds for inhibiting cell proliferation in egfr-driven cancers |
| AU2013204563B2 (en) | 2012-05-05 | 2016-05-19 | Takeda Pharmaceutical Company Limited | Compounds for inhibiting cell proliferation in EGFR-driven cancers |
| CN103539695B (zh) * | 2012-07-12 | 2015-09-09 | 南京圣和药业股份有限公司 | 一种新的取代二苯醚类组蛋白去乙酰化酶抑制剂 |
| DK2915804T3 (da) * | 2012-10-31 | 2019-06-03 | Fujifilm Toyama Chemical Co Ltd | Nyt aminderivat eller salt deraf som TNF-alpha-inhibitorer |
| US9611283B1 (en) | 2013-04-10 | 2017-04-04 | Ariad Pharmaceuticals, Inc. | Methods for inhibiting cell proliferation in ALK-driven cancers |
| CA2916653C (en) | 2013-06-27 | 2017-07-18 | Pfizer Inc. | Heteroaromatic compounds and their use as dopamine d1 ligands |
| PT3131582T (pt) | 2014-04-15 | 2018-10-08 | Vertex Pharma | Composições farmacêuticas para o tratamento de doenças mediadas pelo regulador de condutância transmembranar da fibrose quística |
| PT3203840T (pt) * | 2014-10-06 | 2020-10-27 | Vertex Pharma | Moduladores do regulador da condutância transmembranar da fibrose quística |
| US10738030B2 (en) | 2016-03-31 | 2020-08-11 | Vertex Pharmaceuticals Incorporated | Modulators of cystic fibrosis transmembrane conductance regulator |
| LT3519401T (lt) | 2016-09-30 | 2021-11-25 | Vertex Pharmaceuticals Incorporated | Cistinės fibrozės transmembraninio laidumo reguliavimo moduliatorius, farmacinės kompozicijos, gydymo būdai ir moduliatoriaus gamybos būdas |
| MX2021013639A (es) | 2016-12-09 | 2022-09-30 | Vertex Pharma | Forma cristalina del compuesto 1, un modulador del regulador de conductancia transmembrana de fibrosis quística, procesos para su preparación, composiciones farmacéuticas del compuesto 1, y su uso en el tratamiento de fibrosis quística. |
| CA3066084A1 (en) | 2017-06-08 | 2018-12-13 | Vertex Pharmaceuticals Incorporated | Methods of treatment for cystic fibrosis |
| AU2018304168B2 (en) | 2017-07-17 | 2023-05-04 | Vertex Pharmaceuticals Incorporated | Methods of treatment for cystic fibrosis |
| CN111051280B (zh) | 2017-08-02 | 2023-12-22 | 弗特克斯药品有限公司 | 制备吡咯烷化合物的方法 |
| TWI719349B (zh) | 2017-10-19 | 2021-02-21 | 美商維泰克斯製藥公司 | Ｃｆｔｒ調節劑之結晶形式及組合物 |
| MA51039A (fr) | 2017-12-08 | 2020-10-14 | Vertex Pharma | Procédés pour préparer des modulateurs du régulateur de la conductance transmembranaire de la mucoviscidose |
| JP2021512105A (ja) | 2018-01-31 | 2021-05-13 | デシフェラ・ファーマシューティカルズ，エルエルシー | 消化管間質腫瘍の治療のための併用療法 |
| JP7523351B2 (ja) | 2018-01-31 | 2024-07-26 | デシフェラ・ファーマシューティカルズ，エルエルシー | 肥満細胞症の治療のための併用療法 |
| TWI810243B (zh) | 2018-02-05 | 2023-08-01 | 美商維泰克斯製藥公司 | 用於治療囊腫纖化症之醫藥組合物 |
| EP3774825A1 (en) | 2018-04-13 | 2021-02-17 | Vertex Pharmaceuticals Incorporated | Modulators of cystic fibrosis transmembrane conductance regulator, pharmaceutical compositions, methods of treatment, and process for making the modulator |
| US11905268B2 (en) * | 2018-08-10 | 2024-02-20 | University Of Central Florida Research Foundation, Inc. | Anthranilic acid derivatives and their use in the treatment of human cancers |
| NZ784949A (en) | 2019-08-12 | 2025-09-26 | Deciphera Pharmaceuticals Llc | Ripretinib for treating gastrointestinal stromal tumors |
| TWI878335B (zh) | 2019-08-12 | 2025-04-01 | 美商迪賽孚爾製藥有限公司 | 治療胃腸道基質瘤方法 |
| AU2020419197B2 (en) | 2019-12-30 | 2023-08-31 | Deciphera Pharmaceuticals, Llc | Amorphous kinase inhibitor formulations and methods of use thereof |
| NZ789199A (en) | 2019-12-30 | 2025-07-25 | Deciphera Pharmaceuticals Llc | Compositions of 1-(4-bromo-5-(1-ethyl-7-(methylamino)-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl)-2-fluorophenyl)-3-phenylurea |
| US20230255906A1 (en) * | 2020-07-02 | 2023-08-17 | The Brigham And Women`S Hospital, Inc. | Targeting Serpin B9 in Cancer |
| WO2023107705A1 (en) | 2021-12-10 | 2023-06-15 | Incyte Corporation | Bicyclic amines as cdk12 inhibitors |
| KR102769394B1 (ko) * | 2022-01-20 | 2025-02-17 | 동아대학교 산학협력단 | 아베난쓰라마이드 c의 합성 방법 |
| US11779572B1 (en) | 2022-09-02 | 2023-10-10 | Deciphera Pharmaceuticals, Llc | Methods of treating gastrointestinal stromal tumors |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5334598A (en) * | 1993-03-19 | 1994-08-02 | Merck & Co., Inc. | Six-membered ring fused imidazoles substituted with phenoxyphenylacetic acid derivatives |
| US5565485A (en) * | 1993-03-19 | 1996-10-15 | Merck & Co., Inc. | Biphenyl compounds useful or endothelin antagonists |
| US5391566A (en) * | 1993-07-20 | 1995-02-21 | Merck & Co., Inc. | Benzimidazolinones substituted with phenoxyphenylacetic acid derivatives |
| BRPI0512273A (pt) * | 2004-06-18 | 2008-02-19 | Millennium Pharm Inc | inibidores do fator xa |
| EP1786421A2 (en) * | 2004-07-09 | 2007-05-23 | Cengent Therapeutics, Inc. | Oxygen/nitrogen heterocycle inhibitors of tyrosine phosphatases |
| KR20080077620A (ko) * | 2005-12-05 | 2008-08-25 | 뉴로서치 에이/에스 | 벤즈이미다졸 및 ｇａｂａａ 수용체 복합체를 조절하기위한 이의 용도 |
| TW200825054A (en) * | 2006-10-18 | 2008-06-16 | Wyeth Corp | Quinoline compounds |
| US20090069373A1 (en) * | 2007-02-28 | 2009-03-12 | Wyeth | Quinoline Acids |
| TW200900072A (en) * | 2007-03-22 | 2009-01-01 | Arete Therapeutics Inc | Soluble epoxide hydrolase inhibitors |
| MX2010001784A (es) * | 2007-08-13 | 2010-03-15 | Metabasis Therapeutics Inc | Activadores novedosos de la glucocinasa. |
| CA2710452A1 (en) * | 2007-12-21 | 2009-07-09 | Wyeth Llc | Imidazo [1,2-a] pyridine compounds |
-
2009
- 2009-04-16 JP JP2011504523A patent/JP2011520785A/ja not_active Withdrawn
- 2009-04-16 US US12/937,799 patent/US20110071197A1/en not_active Abandoned
- 2009-04-16 CA CA2721452A patent/CA2721452A1/en not_active Abandoned
- 2009-04-16 EP EP09732385A patent/EP2274280A2/en not_active Withdrawn
- 2009-04-16 WO PCT/GB2009/000966 patent/WO2009127822A2/en not_active Ceased
- 2009-04-16 CN CN2009801131483A patent/CN102036952A/zh active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2011520785A5 (enExample) | ||
| JP2011520854A5 (enExample) | ||
| JP2010538052A5 (enExample) | ||
| JP2013040159A5 (ja) | 有機金属錯体 | |
| JP2012087114A5 (ja) | カルバゾール誘導体 | |
| RU2011116129A (ru) | 1н-бензимидазол-5-карбоксамиды в качестве противовоспалительных средств | |
| JP2011513410A5 (enExample) | ||
| JP2009535462A5 (enExample) | ||
| JP2012531433A5 (enExample) | ||
| JP2014526533A5 (enExample) | ||
| JP2006503068A5 (enExample) | ||
| JP2011121940A5 (ja) | 発光素子 | |
| JP2010511721A5 (enExample) | ||
| JP2008510770A5 (enExample) | ||
| JP2009535358A5 (enExample) | ||
| JP2010504908A5 (enExample) | ||
| JP2012054542A5 (ja) | トリアゾール誘導体および複素環化合物 | |
| JP2011520775A5 (enExample) | ||
| WO2010089510A3 (fr) | Dérivés d'azaspiranyl-alkylcarbamates d'hétérocycles à 5 chaînons, leur préparation et leur application en thérapeutique | |
| JP2013541600A5 (enExample) | ||
| JP2014509612A5 (enExample) | ||
| JP2006508979A5 (enExample) | ||
| JP2010254679A5 (ja) | トリアゾール誘導体、発光素子、及び発光装置 | |
| JP2011506566A5 (enExample) | ||
| JP2013502441A5 (enExample) |