JP2011520854A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2011520854A5 JP2011520854A5 JP2011509001A JP2011509001A JP2011520854A5 JP 2011520854 A5 JP2011520854 A5 JP 2011520854A5 JP 2011509001 A JP2011509001 A JP 2011509001A JP 2011509001 A JP2011509001 A JP 2011509001A JP 2011520854 A5 JP2011520854 A5 JP 2011520854A5
- Authority
- JP
- Japan
- Prior art keywords
- independently
- group
- substituted
- optionally
- substituents selected
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 125000001424 substituent group Chemical group 0.000 claims 40
- 125000000217 alkyl group Chemical group 0.000 claims 14
- 125000005843 halogen group Chemical group 0.000 claims 13
- 229910052739 hydrogen Inorganic materials 0.000 claims 13
- 239000001257 hydrogen Substances 0.000 claims 11
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 10
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 9
- 125000003118 aryl group Chemical group 0.000 claims 8
- 125000004429 atom Chemical group 0.000 claims 8
- 125000001072 heteroaryl group Chemical group 0.000 claims 8
- 125000004093 cyano group Chemical group *C#N 0.000 claims 7
- 125000005842 heteroatom Chemical group 0.000 claims 6
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims 6
- 125000001153 fluoro group Chemical group F* 0.000 claims 5
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 4
- 125000001309 chloro group Chemical group Cl* 0.000 claims 4
- 125000006850 spacer group Chemical group 0.000 claims 4
- 125000004209 (C1-C8) alkyl group Chemical group 0.000 claims 3
- -1 dodecyloxy, decyloxy Chemical group 0.000 claims 3
- 229910052757 nitrogen Inorganic materials 0.000 claims 3
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 3
- 125000004203 4-hydroxyphenyl group Chemical group [H]OC1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 2
- 238000006467 substitution reaction Methods 0.000 claims 2
- 125000003161 (C1-C6) alkylene group Chemical group 0.000 claims 1
- 125000004432 carbon atom Chemical group C* 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 125000003707 hexyloxy group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])O* 0.000 claims 1
- 150000002431 hydrogen Chemical class 0.000 claims 1
- 125000005447 octyloxy group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])O* 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US7171508P | 2008-05-14 | 2008-05-14 | |
| US61/071,715 | 2008-05-14 | ||
| PCT/GB2009/001227 WO2009138758A2 (en) | 2008-05-14 | 2009-05-14 | Bis-aryl compounds for use as medicaments |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2011520854A JP2011520854A (ja) | 2011-07-21 |
| JP2011520854A5 true JP2011520854A5 (enExample) | 2012-06-28 |
Family
ID=41202349
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011509001A Withdrawn JP2011520854A (ja) | 2008-05-14 | 2009-05-14 | 薬剤としての使用のためのビスアリール化合物 |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US20110112193A1 (enExample) |
| EP (1) | EP2294050A2 (enExample) |
| JP (1) | JP2011520854A (enExample) |
| WO (1) | WO2009138758A2 (enExample) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8563573B2 (en) | 2007-11-02 | 2013-10-22 | Vertex Pharmaceuticals Incorporated | Azaindole derivatives as CFTR modulators |
| US20120035217A1 (en) * | 2009-03-12 | 2012-02-09 | Biolipox Ab | Bis Aromatic Compounds for Use as LTC4 Synthase Inhibitors |
| US8802868B2 (en) | 2010-03-25 | 2014-08-12 | Vertex Pharmaceuticals Incorporated | Solid forms of (R)-1(2,2-difluorobenzo[D][1,3]dioxo1-5-yl)-N-(1-(2,3-dihydroxypropyl-6-fluoro-2-(1-hydroxy-2-methylpropan2-yl)-1H-Indol-5-yl)-Cyclopropanecarboxamide |
| RU2569678C2 (ru) | 2010-04-22 | 2015-11-27 | Вертекс Фармасьютикалз Инкорпорейтед | Способ получения циклоалкилкарбоксамидо-индольных соединений |
| US9085562B2 (en) * | 2011-03-03 | 2015-07-21 | Vanderbilt University | 6-alkyl-N-(pyridin-2-yl)-4-aryloxypicolinamide analogs as mGluR5 negative allosteric modulators and methods of making and using the same |
| CA2916653C (en) | 2013-06-27 | 2017-07-18 | Pfizer Inc. | Heteroaromatic compounds and their use as dopamine d1 ligands |
| PT3131582T (pt) | 2014-04-15 | 2018-10-08 | Vertex Pharma | Composições farmacêuticas para o tratamento de doenças mediadas pelo regulador de condutância transmembranar da fibrose quística |
| PT3203840T (pt) | 2014-10-06 | 2020-10-27 | Vertex Pharma | Moduladores do regulador da condutância transmembranar da fibrose quística |
| WO2016198374A1 (en) | 2015-06-10 | 2016-12-15 | Bayer Pharma Aktiengesellschaft | Aromatic sulfonamide derivatives |
| US10738030B2 (en) | 2016-03-31 | 2020-08-11 | Vertex Pharmaceuticals Incorporated | Modulators of cystic fibrosis transmembrane conductance regulator |
| EP3456712B1 (en) * | 2016-05-12 | 2022-04-20 | Nanjing Shiqi Pharmaceutical Co. Ltd. | Novel 2,4,6-trisubstituted s-triazine compound, preparation method therefor, and use thereof |
| LT3519401T (lt) | 2016-09-30 | 2021-11-25 | Vertex Pharmaceuticals Incorporated | Cistinės fibrozės transmembraninio laidumo reguliavimo moduliatorius, farmacinės kompozicijos, gydymo būdai ir moduliatoriaus gamybos būdas |
| MX2021013639A (es) | 2016-12-09 | 2022-09-30 | Vertex Pharma | Forma cristalina del compuesto 1, un modulador del regulador de conductancia transmembrana de fibrosis quística, procesos para su preparación, composiciones farmacéuticas del compuesto 1, y su uso en el tratamiento de fibrosis quística. |
| CA3066084A1 (en) | 2017-06-08 | 2018-12-13 | Vertex Pharmaceuticals Incorporated | Methods of treatment for cystic fibrosis |
| AU2018304168B2 (en) | 2017-07-17 | 2023-05-04 | Vertex Pharmaceuticals Incorporated | Methods of treatment for cystic fibrosis |
| CN111051280B (zh) | 2017-08-02 | 2023-12-22 | 弗特克斯药品有限公司 | 制备吡咯烷化合物的方法 |
| TWI719349B (zh) | 2017-10-19 | 2021-02-21 | 美商維泰克斯製藥公司 | Ｃｆｔｒ調節劑之結晶形式及組合物 |
| MA51039A (fr) | 2017-12-08 | 2020-10-14 | Vertex Pharma | Procédés pour préparer des modulateurs du régulateur de la conductance transmembranaire de la mucoviscidose |
| JP2021512105A (ja) | 2018-01-31 | 2021-05-13 | デシフェラ・ファーマシューティカルズ，エルエルシー | 消化管間質腫瘍の治療のための併用療法 |
| JP7523351B2 (ja) | 2018-01-31 | 2024-07-26 | デシフェラ・ファーマシューティカルズ，エルエルシー | 肥満細胞症の治療のための併用療法 |
| TWI810243B (zh) | 2018-02-05 | 2023-08-01 | 美商維泰克斯製藥公司 | 用於治療囊腫纖化症之醫藥組合物 |
| EP3774825A1 (en) | 2018-04-13 | 2021-02-17 | Vertex Pharmaceuticals Incorporated | Modulators of cystic fibrosis transmembrane conductance regulator, pharmaceutical compositions, methods of treatment, and process for making the modulator |
| TWI878335B (zh) | 2019-08-12 | 2025-04-01 | 美商迪賽孚爾製藥有限公司 | 治療胃腸道基質瘤方法 |
| NZ784949A (en) | 2019-08-12 | 2025-09-26 | Deciphera Pharmaceuticals Llc | Ripretinib for treating gastrointestinal stromal tumors |
| AU2020419197B2 (en) | 2019-12-30 | 2023-08-31 | Deciphera Pharmaceuticals, Llc | Amorphous kinase inhibitor formulations and methods of use thereof |
| NZ789199A (en) | 2019-12-30 | 2025-07-25 | Deciphera Pharmaceuticals Llc | Compositions of 1-(4-bromo-5-(1-ethyl-7-(methylamino)-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl)-2-fluorophenyl)-3-phenylurea |
| US11779572B1 (en) | 2022-09-02 | 2023-10-10 | Deciphera Pharmaceuticals, Llc | Methods of treating gastrointestinal stromal tumors |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4992576A (en) * | 1987-01-12 | 1991-02-12 | Eli Lilly And Company | Intermediates for leukotriene antagonists |
| CA1320490C (en) * | 1987-01-12 | 1993-07-20 | Darrel M. Gapinski | Anti-inflammatory agents |
| US4892578A (en) * | 1987-11-06 | 1990-01-09 | Fmc Corporation | Phenylmethyl-4,4-dimethyl-3-isoxazolidinone plant regulators |
| ZA929051B (en) * | 1991-11-25 | 1994-05-23 | Lilly Co Eli | Substituted phenyl phenol leukotriene antagonists |
| US5565485A (en) * | 1993-03-19 | 1996-10-15 | Merck & Co., Inc. | Biphenyl compounds useful or endothelin antagonists |
| US5334598A (en) * | 1993-03-19 | 1994-08-02 | Merck & Co., Inc. | Six-membered ring fused imidazoles substituted with phenoxyphenylacetic acid derivatives |
| DE19648793A1 (de) * | 1996-11-26 | 1998-05-28 | Basf Ag | Neue Benzamide und deren Anwendung |
| US7264932B2 (en) * | 1999-09-24 | 2007-09-04 | Applera Corporation | Nuclease inhibitor cocktail |
| GB0008264D0 (en) * | 2000-04-04 | 2000-05-24 | Smithkline Beecham Plc | Novel method and compounds |
| DE60210754T2 (de) * | 2001-02-06 | 2007-03-29 | Mitsubishi Chemical Corp. | Verzweigtes aromatisches polycarbonat und verfahren zu seiner herstellung |
| US7169785B2 (en) * | 2001-09-21 | 2007-01-30 | Reddy Us Therapeutics, Inc. | Methods and compositions of novel triazine compounds |
| US20030097010A1 (en) * | 2001-09-27 | 2003-05-22 | Vogel Dennis E. | Process for preparing pentacene derivatives |
| US20040082641A1 (en) * | 2002-10-28 | 2004-04-29 | Rytved Klaus Asger | Use of glycogen phosphorylase inhibitors for treatment of cardiovascular diseases |
| US7112585B2 (en) * | 2003-04-18 | 2006-09-26 | Bristol-Myers Squibb Company | Pyrimidine derivatives as corticotropin releasing factor inhibitors |
| WO2005035507A2 (en) * | 2003-10-10 | 2005-04-21 | Bayer Pharmaceuticals Corporation | 4-aminopyrimidine derivatives for treatment of hyperproliferative disorders |
| DE10349587A1 (de) * | 2003-10-24 | 2005-05-25 | Merck Patent Gmbh | Benzimidazolylderivate |
| ES2299080T3 (es) * | 2004-05-14 | 2008-05-16 | Millennium Pharmaceuticals, Inc. | Compuestos y metodos para inhibir la progresion mitotica mediante la inhibicion de quinasas aurora. |
| US20090069373A1 (en) * | 2007-02-28 | 2009-03-12 | Wyeth | Quinoline Acids |
| WO2009030887A2 (en) * | 2007-09-04 | 2009-03-12 | Biolipox Ab | Bis-aromatic compounds useful in the treatment of inflammation |
-
2009
- 2009-05-05 US US12/992,074 patent/US20110112193A1/en not_active Abandoned
- 2009-05-14 EP EP09746075A patent/EP2294050A2/en not_active Withdrawn
- 2009-05-14 JP JP2011509001A patent/JP2011520854A/ja not_active Withdrawn
- 2009-05-14 WO PCT/GB2009/001227 patent/WO2009138758A2/en not_active Ceased
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2011520854A5 (enExample) | ||
| JP2011520785A5 (enExample) | ||
| JP2013040159A5 (ja) | 有機金属錯体 | |
| JP2019211764A5 (enExample) | ||
| JP2014518311A5 (enExample) | ||
| JP2012180333A5 (enExample) | ||
| JP2012149030A5 (ja) | 化合物 | |
| JP2013129675A5 (enExample) | ||
| JP2016500082A5 (enExample) | ||
| JP2012531433A5 (enExample) | ||
| JP2012140458A5 (enExample) | ||
| JP2014515349A5 (enExample) | ||
| JP2013147490A5 (ja) | イリジウム錯体 | |
| JP2006527170A5 (enExample) | ||
| JP2011121940A5 (ja) | 発光素子 | |
| JP2010538052A5 (enExample) | ||
| JP2012526842A5 (enExample) | ||
| JP2014058672A5 (enExample) | ||
| JP2013010752A5 (ja) | 有機金属錯体 | |
| JP2012007168A5 (enExample) | ||
| WO2010073261A3 (en) | Asphalt-mineral compositions containing a cationic organosilicon compound | |
| JP2011503096A5 (enExample) | ||
| JP2006508979A5 (enExample) | ||
| JP2010280888A5 (enExample) | ||
| WO2010076969A3 (ko) | 구리 프탈로시아닌 화합물 및 이를 이용한 근적외선 흡수 필터 |