JP2011517668A5 - - Google Patents
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- Publication number
- JP2011517668A5 JP2011517668A5 JP2011501140A JP2011501140A JP2011517668A5 JP 2011517668 A5 JP2011517668 A5 JP 2011517668A5 JP 2011501140 A JP2011501140 A JP 2011501140A JP 2011501140 A JP2011501140 A JP 2011501140A JP 2011517668 A5 JP2011517668 A5 JP 2011517668A5
- Authority
- JP
- Japan
- Prior art keywords
- cyclohexyl
- phenyl
- dimethyl
- aryl
- methyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 150000001875 compounds Chemical class 0.000 claims description 15
- 239000003814 drug Substances 0.000 claims description 5
- 208000024827 Alzheimer disease Diseases 0.000 claims description 4
- 208000007271 Substance Withdrawal Syndrome Diseases 0.000 claims description 4
- 208000019901 Anxiety disease Diseases 0.000 claims description 3
- 230000036506 anxiety Effects 0.000 claims description 3
- 206010006895 Cachexia Diseases 0.000 claims description 2
- 208000024172 Cardiovascular disease Diseases 0.000 claims description 2
- 206010011878 Deafness Diseases 0.000 claims description 2
- 206010012735 Diarrhoea Diseases 0.000 claims description 2
- 206010020772 Hypertension Diseases 0.000 claims description 2
- 208000001953 Hypotension Diseases 0.000 claims description 2
- 208000019695 Migraine disease Diseases 0.000 claims description 2
- 208000008589 Obesity Diseases 0.000 claims description 2
- 208000026251 Opioid-Related disease Diseases 0.000 claims description 2
- 208000003251 Pruritus Diseases 0.000 claims description 2
- 206010039966 Senile dementia Diseases 0.000 claims description 2
- 201000001880 Sexual dysfunction Diseases 0.000 claims description 2
- 208000009205 Tinnitus Diseases 0.000 claims description 2
- 206010046543 Urinary incontinence Diseases 0.000 claims description 2
- 230000003444 anaesthetic effect Effects 0.000 claims description 2
- 208000022531 anorexia Diseases 0.000 claims description 2
- 230000001773 anti-convulsant effect Effects 0.000 claims description 2
- 239000001961 anticonvulsive agent Substances 0.000 claims description 2
- 229960003965 antiepileptics Drugs 0.000 claims description 2
- 239000003795 chemical substances by application Substances 0.000 claims description 2
- 208000010877 cognitive disease Diseases 0.000 claims description 2
- 206010061428 decreased appetite Diseases 0.000 claims description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 2
- 208000035475 disorder Diseases 0.000 claims description 2
- 206010015037 epilepsy Diseases 0.000 claims description 2
- 230000037406 food intake Effects 0.000 claims description 2
- 235000012631 food intake Nutrition 0.000 claims description 2
- 239000003193 general anesthetic agent Substances 0.000 claims description 2
- 230000010370 hearing loss Effects 0.000 claims description 2
- 231100000888 hearing loss Toxicity 0.000 claims description 2
- 208000016354 hearing loss disease Diseases 0.000 claims description 2
- 230000036543 hypotension Effects 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 claims description 2
- 206010027599 migraine Diseases 0.000 claims description 2
- 230000037023 motor activity Effects 0.000 claims description 2
- 230000004770 neurodegeneration Effects 0.000 claims description 2
- 208000015122 neurodegenerative disease Diseases 0.000 claims description 2
- 230000001777 nootropic effect Effects 0.000 claims description 2
- 235000020824 obesity Nutrition 0.000 claims description 2
- 201000005040 opiate dependence Diseases 0.000 claims description 2
- 239000000014 opioid analgesic Substances 0.000 claims description 2
- 229940005483 opioid analgesics Drugs 0.000 claims description 2
- 229940052318 opioid anesthetics Drugs 0.000 claims description 2
- 231100000872 sexual dysfunction Toxicity 0.000 claims description 2
- 208000011580 syndromic disease Diseases 0.000 claims description 2
- 231100000886 tinnitus Toxicity 0.000 claims description 2
- 125000003118 aryl group Chemical group 0.000 claims 14
- 125000001072 heteroaryl group Chemical group 0.000 claims 7
- 150000003839 salts Chemical class 0.000 claims 6
- 238000006467 substitution reaction Methods 0.000 claims 5
- 239000000203 mixture Substances 0.000 claims 4
- 125000005842 heteroatom Chemical group 0.000 claims 3
- 125000000623 heterocyclic group Chemical group 0.000 claims 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 3
- 229920006395 saturated elastomer Polymers 0.000 claims 3
- 125000001424 substituent group Chemical group 0.000 claims 3
- LMGRWQJTGSSYSK-UHFFFAOYSA-N 1-(3-fluorophenyl)-1-n,1-n,4-n,4-n-tetramethyl-4-(3-methyl-1h-indol-2-yl)cyclohexane-1,4-diamine Chemical compound C1CC(N(C)C)(C2=C(C3=CC=CC=C3N2)C)CCC1(N(C)C)C1=CC=CC(F)=C1 LMGRWQJTGSSYSK-UHFFFAOYSA-N 0.000 claims 2
- ZVBXEEQAMRJRMZ-UHFFFAOYSA-N 1-(4-methoxyphenyl)-1-n,1-n,4-n,4-n-tetramethyl-4-phenylcyclohexane-1,4-diamine Chemical compound C1=CC(OC)=CC=C1C1(N(C)C)CCC(C=2C=CC=CC=2)(N(C)C)CC1 ZVBXEEQAMRJRMZ-UHFFFAOYSA-N 0.000 claims 2
- MSXDOMMCSPGVPW-UHFFFAOYSA-N 1-(5-fluoro-3-methyl-1h-indol-2-yl)-1-n,1-n,4-n,4-n-tetramethyl-4-phenylcyclohexane-1,4-diamine Chemical compound C1CC(N(C)C)(C2=C(C3=CC(F)=CC=C3N2)C)CCC1(N(C)C)C1=CC=CC=C1 MSXDOMMCSPGVPW-UHFFFAOYSA-N 0.000 claims 2
- WYUNMCFJWKBZGT-UHFFFAOYSA-N 1-(cyclopentylmethyl)-1-n,1-n,4-n,4-n-tetramethyl-4-phenylcyclohexane-1,4-diamine Chemical compound C1CC(C=2C=CC=CC=2)(N(C)C)CCC1(N(C)C)CC1CCCC1 WYUNMCFJWKBZGT-UHFFFAOYSA-N 0.000 claims 2
- ULAJDCSBVPZPLE-UHFFFAOYSA-N 1-butyl-1-n,1-n,4-n,4-n-tetramethyl-4-phenylcyclohexane-1,4-diamine Chemical compound C1CC(CCCC)(N(C)C)CCC1(N(C)C)C1=CC=CC=C1 ULAJDCSBVPZPLE-UHFFFAOYSA-N 0.000 claims 2
- VNYIXWZEXZEHQB-UHFFFAOYSA-N 1-n,1-n,4-n,4-n-tetramethyl-1-(3-methyl-1h-indol-2-yl)-4-phenylcyclohexane-1,4-diamine Chemical compound C1CC(N(C)C)(C2=C(C3=CC=CC=C3N2)C)CCC1(N(C)C)C1=CC=CC=C1 VNYIXWZEXZEHQB-UHFFFAOYSA-N 0.000 claims 2
- KXSLNFUDGWMNKK-UHFFFAOYSA-N 1-n,1-n,4-n,4-n-tetramethyl-1-phenyl-4-[4-(trifluoromethyl)phenyl]cyclohexane-1,4-diamine Chemical compound C1CC(N(C)C)(C=2C=CC=CC=2)CCC1(N(C)C)C1=CC=C(C(F)(F)F)C=C1 KXSLNFUDGWMNKK-UHFFFAOYSA-N 0.000 claims 2
- KAHACFHOOARSEP-UHFFFAOYSA-N 1-n,1-n,4-n,4-n-tetramethyl-1-phenyl-4-thiophen-2-ylcyclohexane-1,4-diamine Chemical compound C1CC(N(C)C)(C=2SC=CC=2)CCC1(N(C)C)C1=CC=CC=C1 KAHACFHOOARSEP-UHFFFAOYSA-N 0.000 claims 2
- ULPRFMGFIKYAMU-UHFFFAOYSA-N 4-n-butyl-1-n,1-n,4-n-trimethyl-1,4-diphenylcyclohexane-1,4-diamine Chemical compound C1CC(N(C)CCCC)(C=2C=CC=CC=2)CCC1(N(C)C)C1=CC=CC=C1 ULPRFMGFIKYAMU-UHFFFAOYSA-N 0.000 claims 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 2
- 125000004432 carbon atom Chemical group C* 0.000 claims 2
- 125000004122 cyclic group Chemical group 0.000 claims 2
- 125000001183 hydrocarbyl group Chemical group 0.000 claims 2
- 125000003367 polycyclic group Chemical group 0.000 claims 2
- SGNVONLZSXAOEF-UHFFFAOYSA-N 1-benzyl-1-n,1-n,4-n,4-n-tetramethyl-4-phenylcyclohexane-1,4-diamine Chemical compound C1CC(C=2C=CC=CC=2)(N(C)C)CCC1(N(C)C)CC1=CC=CC=C1 SGNVONLZSXAOEF-UHFFFAOYSA-N 0.000 claims 1
- MYSRDSFKRAXUPG-UHFFFAOYSA-N 1-n,1-n,4-n,4-n-tetramethyl-1,4-diphenylcyclohexane-1,4-diamine Chemical compound C1CC(N(C)C)(C=2C=CC=CC=2)CCC1(N(C)C)C1=CC=CC=C1 MYSRDSFKRAXUPG-UHFFFAOYSA-N 0.000 claims 1
- VXIYQFNYPPDKST-UHFFFAOYSA-N 1-n,1-n,4-n,4-n-tetramethyl-1-(1-methylindole-2-carboximidoyl)-4-phenylcyclohexane-1,4-diamine Chemical compound C1CC(N(C)C)(C(=N)C=2N(C3=CC=CC=C3C=2)C)CCC1(N(C)C)C1=CC=CC=C1 VXIYQFNYPPDKST-UHFFFAOYSA-N 0.000 claims 1
- 208000028698 Cognitive impairment Diseases 0.000 claims 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 1
- 208000002193 Pain Diseases 0.000 claims 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims 1
- LVHNIEBAXNIGRG-UHFFFAOYSA-N [1,4-bis(dimethylamino)-4-phenylcyclohexyl]-(1-methylindol-2-yl)methanone Chemical compound C1CC(N(C)C)(C(=O)C=2N(C3=CC=CC=C3C=2)C)CCC1(N(C)C)C1=CC=CC=C1 LVHNIEBAXNIGRG-UHFFFAOYSA-N 0.000 claims 1
- 239000000654 additive Substances 0.000 claims 1
- 125000001931 aliphatic group Chemical group 0.000 claims 1
- 230000036528 appetite Effects 0.000 claims 1
- 235000019789 appetite Nutrition 0.000 claims 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 1
- 125000002619 bicyclic group Chemical group 0.000 claims 1
- 229910052799 carbon Inorganic materials 0.000 claims 1
- 239000002934 diuretic Substances 0.000 claims 1
- 230000001882 diuretic effect Effects 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 230000029142 excretion Effects 0.000 claims 1
- 230000001771 impaired effect Effects 0.000 claims 1
- 206010027175 memory impairment Diseases 0.000 claims 1
- 239000003158 myorelaxant agent Substances 0.000 claims 1
- 230000003957 neurotransmitter release Effects 0.000 claims 1
- 229910052757 nitrogen Inorganic materials 0.000 claims 1
- 210000000056 organ Anatomy 0.000 claims 1
- 229910052760 oxygen Inorganic materials 0.000 claims 1
- 239000001301 oxygen Substances 0.000 claims 1
- 125000006413 ring segment Chemical group 0.000 claims 1
- 239000011734 sodium Substances 0.000 claims 1
- 229910052708 sodium Inorganic materials 0.000 claims 1
- 239000012453 solvate Substances 0.000 claims 1
- 239000011593 sulfur Substances 0.000 claims 1
- 229910052717 sulfur Inorganic materials 0.000 claims 1
- 206010013654 Drug abuse Diseases 0.000 description 2
- 208000011117 substance-related disease Diseases 0.000 description 2
- 206010012335 Dependence Diseases 0.000 description 1
- 206010021118 Hypotonia Diseases 0.000 description 1
- 208000020358 Learning disease Diseases 0.000 description 1
- 208000026139 Memory disease Diseases 0.000 description 1
- 208000004880 Polyuria Diseases 0.000 description 1
- 239000002249 anxiolytic agent Substances 0.000 description 1
- 230000000949 anxiolytic effect Effects 0.000 description 1
- 230000035619 diuresis Effects 0.000 description 1
- 230000008991 intestinal motility Effects 0.000 description 1
- 201000003723 learning disability Diseases 0.000 description 1
- 230000036640 muscle relaxation Effects 0.000 description 1
- 239000002858 neurotransmitter agent Substances 0.000 description 1
- 239000002664 nootropic agent Substances 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP08005748.2 | 2008-03-27 | ||
| EP08005748 | 2008-03-27 | ||
| PCT/EP2009/002179 WO2009118168A1 (de) | 2008-03-27 | 2009-03-25 | Substituierte 4-aminocyclohexan-derivate |
Related Child Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012146520A Division JP5674722B2 (ja) | 2008-03-27 | 2012-06-29 | 置換された４−アミノシクロヘキサン誘導体 |
| JP2012146521A Division JP5674723B2 (ja) | 2008-03-27 | 2012-06-29 | 置換された４−アミノシクロヘキサン誘導体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011517668A JP2011517668A (ja) | 2011-06-16 |
| JP2011517668A5 true JP2011517668A5 (cg-RX-API-DMAC10.html) | 2013-02-28 |
| JP5674635B2 JP5674635B2 (ja) | 2015-02-25 |
Family
ID=39628983
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011501140A Expired - Fee Related JP5674635B2 (ja) | 2008-03-27 | 2009-03-25 | 置換された４−アミノシクロヘキサン誘導体 |
| JP2012146520A Expired - Fee Related JP5674722B2 (ja) | 2008-03-27 | 2012-06-29 | 置換された４−アミノシクロヘキサン誘導体 |
| JP2012146521A Expired - Fee Related JP5674723B2 (ja) | 2008-03-27 | 2012-06-29 | 置換された４−アミノシクロヘキサン誘導体 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012146520A Expired - Fee Related JP5674722B2 (ja) | 2008-03-27 | 2012-06-29 | 置換された４−アミノシクロヘキサン誘導体 |
| JP2012146521A Expired - Fee Related JP5674723B2 (ja) | 2008-03-27 | 2012-06-29 | 置換された４−アミノシクロヘキサン誘導体 |
Country Status (21)
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20120075500A (ko) * | 2008-03-27 | 2012-07-06 | 그뤼넨탈 게엠베하 | 치환된 4-아미노사이클로헥산 유도체 |
| JP5542119B2 (ja) | 2008-03-27 | 2014-07-09 | グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング | スピロ（５．５）ウンデカン誘導体 |
| EP2260022B1 (de) | 2008-03-27 | 2017-01-04 | Grünenthal GmbH | Substituierte cyclohexyldiamine |
| HRP20140650T1 (hr) * | 2008-03-27 | 2014-09-26 | Grünenthal GmbH | Hidroksimetilcikloheksilamini |
| CL2009000731A1 (es) | 2008-03-27 | 2009-05-15 | Gruenenthal Gmbh | Compuestos derivados de ciclohexano espirociclicos sustituidos, composicion farmaceutica que contiene a dicho compuesto y su uso como moduladores del receptor de opioides µ y el receptor orl-1 para tratar el dolor, ansiedad, depresion, epilepsia, alzheimer, abuso de alcohol, hipertension, anorexia, obesidad y diarrea. |
| AU2009228637B2 (en) | 2008-03-27 | 2013-12-19 | Grunenthal Gmbh | (Hetero-)aryl cyclohexane derivatives |
| US8993808B2 (en) | 2009-01-21 | 2015-03-31 | Oryzon Genomics, S.A. | Phenylcyclopropylamine derivatives and their medical use |
| WO2011035941A1 (en) | 2009-09-25 | 2011-03-31 | Oryzon Genomics S.A. | Lysine specific demethylase-1 inhibitors and their use |
| US8946296B2 (en) | 2009-10-09 | 2015-02-03 | Oryzon Genomics S.A. | Substituted heteroaryl- and aryl-cyclopropylamine acetamides and their use |
| WO2011106574A2 (en) | 2010-02-24 | 2011-09-01 | Oryzon Genomics, S.A. | Inhibitors for antiviral use |
| WO2011106106A2 (en) | 2010-02-24 | 2011-09-01 | Oryzon Genomics, S.A. | Lysine demethylase inhibitors for diseases and disorders associated with hepadnaviridae |
| RS55348B1 (sr) | 2010-04-19 | 2017-03-31 | Oryzon Gnomics S A | Inhibitori lizin specifične demetilaze-1 i njihova upotreba |
| EP2598480B1 (en) | 2010-07-29 | 2019-04-24 | Oryzon Genomics, S.A. | Cyclopropylamine derivatives useful as lsd1 inhibitors |
| DK2598482T3 (en) | 2010-07-29 | 2018-06-14 | Oryzon Genomics Sa | ARYLCYCLOPROPYLAMINE-BASED DEMETHYLASE INHIBITORS OF LSD1 AND THEIR MEDICAL USE |
| WO2012045883A1 (en) | 2010-10-08 | 2012-04-12 | Oryzon Genomics S.A. | Cyclopropylamine inhibitors of oxidases |
| WO2012072713A2 (en) | 2010-11-30 | 2012-06-07 | Oryzon Genomics, S.A. | Lysine demethylase inhibitors for diseases and disorders associated with flaviviridae |
| EP2712315B1 (en) | 2011-02-08 | 2021-11-24 | Oryzon Genomics, S.A. | Lysine demethylase inhibitors for myeloproliferative disorders |
| AU2012324803B9 (en) | 2011-10-20 | 2017-08-24 | Oryzon Genomics, S.A. | (hetero)aryl cyclopropylamine compounds as LSD1 inhibitors |
| US9469597B2 (en) | 2011-10-20 | 2016-10-18 | Oryzon Genomics S.A. | (Hetero)aryl cyclopropylamine compounds as LSD1 inhibitors |
| AR096845A1 (es) | 2013-07-17 | 2016-02-03 | Gruenenthal Gmbh | Sales de (e)-n-((1s,4s)-4-(dimetilamino)-1,4-difenilciclohexil)-n-metilcinamamida |
| JP2017525753A (ja) | 2014-06-06 | 2017-09-07 | フレクサス・バイオサイエンシーズ・インコーポレイテッドＦｌｅｘｕｓ Ｂｉｏｓｃｉｅｎｃｅｓ， Ｉｎｃ． | 免疫調節剤 |
| TW201607923A (zh) * | 2014-07-15 | 2016-03-01 | 歌林達有限公司 | 被取代之氮螺環（４．５）癸烷衍生物 |
| AR102537A1 (es) | 2014-11-05 | 2017-03-08 | Flexus Biosciences Inc | Agentes inmunomoduladores |
| EA201790806A1 (ru) | 2014-11-05 | 2017-11-30 | Флексус Байосайенсиз, Инк. | Иммунорегулирующие средства |
| UY36390A (es) | 2014-11-05 | 2016-06-01 | Flexus Biosciences Inc | Compuestos moduladores de la enzima indolamina 2,3-dioxigenasa (ido), sus métodos de síntesis y composiciones farmacéuticas que los contienen |
| WO2017114596A1 (en) | 2015-12-28 | 2017-07-06 | Grünenthal GmbH | Crystalline forms of (cis)-n-(4-(dimethylamino)-1,4-diphenylcyclohexyl)-n-methyl-cinnamamide |
| JP6893517B2 (ja) * | 2016-01-13 | 2021-06-23 | グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング | ３−（（ヘテロ−）アリール）−アルキル−８−アミノ−２−オキソ−１，３−ジアザ−スピロ−［４．５］−デカン誘導体 |
| TWI635082B (zh) | 2016-01-13 | 2018-09-11 | 歌林達有限公司 | ３－（（雜－）芳基）－８－胺基－２－側氧－１,３－二氮雜－螺－［４.５］－癸烷衍生物 |
| MX378995B (es) * | 2016-01-13 | 2025-03-11 | Gruenenthal Gmbh | Derivados de 3-(carboximetil)-8-amino-2-oxo-1,3-diaza-espiro-[4.5]-decano. |
| DK3402783T3 (da) * | 2016-01-13 | 2020-05-04 | Gruenenthal Gmbh | 3-(carboxyethyl)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decan-derivater |
| RS60855B1 (sr) * | 2016-01-13 | 2020-10-30 | Gruenenthal Gmbh | Derivati 8-amino-2-okso-1,3-diaza-spiro-[4.5]-dekana |
| TW201908295A (zh) | 2017-07-12 | 2019-03-01 | 德商歌林達有限公司 | １，３－二氮雜－螺－［３．４］－辛烷衍生物 |
| CN110343050B (zh) | 2018-04-04 | 2021-09-24 | 上海键合医药科技有限公司 | 芳香类化合物及其制备方法和用途 |
| JP2021521200A (ja) * | 2018-04-10 | 2021-08-26 | スカイホーク・セラピューティクス・インコーポレーテッド | 癌の処置のための化合物 |
| WO2020156312A1 (zh) * | 2019-01-30 | 2020-08-06 | 江苏豪森药业集团有限公司 | 一种多环类衍生物调节剂、其制备方法和应用 |
| WO2021071981A1 (en) * | 2019-10-08 | 2021-04-15 | Skyhawk Therapeutics, Inc. | Compounds for modulating splicing |
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-
2009
- 2009-03-25 KR KR1020127016152A patent/KR20120075500A/ko not_active Withdrawn
- 2009-03-25 EP EP12003856.7A patent/EP2502907B1/de not_active Not-in-force
- 2009-03-25 NZ NZ600207A patent/NZ600207A/xx not_active IP Right Cessation
- 2009-03-25 RU RU2012120387/04A patent/RU2532545C2/ru not_active IP Right Cessation
- 2009-03-25 JP JP2011501140A patent/JP5674635B2/ja not_active Expired - Fee Related
- 2009-03-25 RU RU2012120389/04A patent/RU2525236C2/ru not_active IP Right Cessation
- 2009-03-25 BR BR122013017387-0A patent/BR122013017387A2/pt not_active IP Right Cessation
- 2009-03-25 PL PL09725217T patent/PL2260021T3/pl unknown
- 2009-03-25 WO PCT/EP2009/002179 patent/WO2009118168A1/de not_active Ceased
- 2009-03-25 BR BR122013017393-5A patent/BR122013017393A2/pt not_active IP Right Cessation
- 2009-03-25 PE PE2009000445A patent/PE20091689A1/es not_active Application Discontinuation
- 2009-03-25 NZ NZ588779A patent/NZ588779A/en not_active IP Right Cessation
- 2009-03-25 PE PE2012000621A patent/PE20121313A1/es not_active Application Discontinuation
- 2009-03-25 EP EP12003857.5A patent/EP2518052B1/de not_active Not-in-force
- 2009-03-25 KR KR1020107023865A patent/KR20100136521A/ko not_active Withdrawn
- 2009-03-25 CN CN2013100686774A patent/CN103214376A/zh active Pending
- 2009-03-25 ES ES12003857.5T patent/ES2663398T3/es active Active
- 2009-03-25 KR KR1020127016148A patent/KR20120075499A/ko not_active Withdrawn
- 2009-03-25 CN CN2013100685875A patent/CN103183630A/zh active Pending
- 2009-03-25 EP EP09725217.5A patent/EP2260021B1/de not_active Not-in-force
- 2009-03-25 AR ARP090101054A patent/AR074615A1/es unknown
- 2009-03-25 CL CL2009000734A patent/CL2009000734A1/es unknown
- 2009-03-25 PE PE2012000622A patent/PE20121314A1/es not_active Application Discontinuation
- 2009-03-25 ES ES12003856.7T patent/ES2694103T3/es active Active
- 2009-03-25 CA CA2719735A patent/CA2719735A1/en not_active Abandoned
- 2009-03-25 US US12/410,801 patent/US20090247530A1/en not_active Abandoned
- 2009-03-25 RU RU2010143438/04A patent/RU2503660C2/ru not_active IP Right Cessation
- 2009-03-25 AU AU2009228642A patent/AU2009228642B2/en not_active Ceased
- 2009-03-25 ES ES09725217.5T patent/ES2464102T3/es active Active
- 2009-03-25 BR BRPI0909527A patent/BRPI0909527A2/pt not_active IP Right Cessation
- 2009-03-25 NZ NZ600210A patent/NZ600210A/xx not_active IP Right Cessation
- 2009-03-25 CN CN200980119483.4A patent/CN102046595B/zh not_active Expired - Fee Related
- 2009-03-25 MX MX2010010407A patent/MX2010010407A/es active IP Right Grant
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- 2010-09-21 IL IL208282A patent/IL208282A0/en unknown
- 2010-09-24 CO CO10118549A patent/CO6251240A2/es active IP Right Grant
- 2010-10-08 EC EC2010010533A patent/ECSP10010533A/es unknown
- 2010-10-26 ZA ZA2010/07647A patent/ZA201007647B/en unknown
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- 2012-05-02 IL IL219530A patent/IL219530A/en not_active IP Right Cessation
- 2012-05-02 IL IL219529A patent/IL219529A/en not_active IP Right Cessation
- 2012-06-29 JP JP2012146520A patent/JP5674722B2/ja not_active Expired - Fee Related
- 2012-06-29 JP JP2012146521A patent/JP5674723B2/ja not_active Expired - Fee Related
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2013
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