JP2017519796A5 - - Google Patents
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- Publication number
- JP2017519796A5 JP2017519796A5 JP2017500083A JP2017500083A JP2017519796A5 JP 2017519796 A5 JP2017519796 A5 JP 2017519796A5 JP 2017500083 A JP2017500083 A JP 2017500083A JP 2017500083 A JP2017500083 A JP 2017500083A JP 2017519796 A5 JP2017519796 A5 JP 2017519796A5
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- JP
- Japan
- Prior art keywords
- formula
- compound
- alkyl
- aryl
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 150000001875 compounds Chemical class 0.000 claims 54
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 36
- 238000006467 substitution reaction Methods 0.000 claims 27
- 125000003118 aryl group Chemical group 0.000 claims 22
- 239000002585 base Substances 0.000 claims 10
- 125000002485 formyl group Chemical group [H]C(*)=O 0.000 claims 10
- 238000000034 method Methods 0.000 claims 9
- QGJOPFRUJISHPQ-UHFFFAOYSA-N Carbon disulfide Chemical compound S=C=S QGJOPFRUJISHPQ-UHFFFAOYSA-N 0.000 claims 6
- 238000004519 manufacturing process Methods 0.000 claims 6
- 125000000217 alkyl group Chemical group 0.000 claims 5
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 claims 4
- OAKJQQAXSVQMHS-UHFFFAOYSA-N Hydrazine Chemical compound NN OAKJQQAXSVQMHS-UHFFFAOYSA-N 0.000 claims 4
- 229910052799 carbon Inorganic materials 0.000 claims 4
- 125000000623 heterocyclic group Chemical group 0.000 claims 4
- 229910052757 nitrogen Inorganic materials 0.000 claims 4
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 4
- 125000006297 carbonyl amino group Chemical group [H]N([*:2])C([*:1])=O 0.000 claims 3
- 238000006243 chemical reaction Methods 0.000 claims 3
- 125000005843 halogen group Chemical group 0.000 claims 3
- 125000001072 heteroaryl group Chemical group 0.000 claims 3
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 3
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 claims 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 2
- 150000001412 amines Chemical class 0.000 claims 2
- 150000001540 azides Chemical class 0.000 claims 2
- 150000001721 carbon Chemical group 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims 2
- JMANVNJQNLATNU-UHFFFAOYSA-N oxalonitrile Chemical compound N#CC#N JMANVNJQNLATNU-UHFFFAOYSA-N 0.000 claims 2
- 238000006722 reduction reaction Methods 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 239000012453 solvate Substances 0.000 claims 2
- 241001385733 Aesculus indica Species 0.000 claims 1
- 238000006969 Curtius rearrangement reaction Methods 0.000 claims 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 1
- AVXURJPOCDRRFD-UHFFFAOYSA-N Hydroxylamine Chemical compound ON AVXURJPOCDRRFD-UHFFFAOYSA-N 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 229910052783 alkali metal Inorganic materials 0.000 claims 1
- 150000001340 alkali metals Chemical class 0.000 claims 1
- IVRMZWNICZWHMI-UHFFFAOYSA-N azide group Chemical group [N-]=[N+]=[N-] IVRMZWNICZWHMI-UHFFFAOYSA-N 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 125000004432 carbon atom Chemical group C* 0.000 claims 1
- PFKFTWBEEFSNDU-UHFFFAOYSA-N carbonyldiimidazole Chemical compound C1=CN=CN1C(=O)N1C=CN=C1 PFKFTWBEEFSNDU-UHFFFAOYSA-N 0.000 claims 1
- 150000001732 carboxylic acid derivatives Chemical group 0.000 claims 1
- 125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 150000002357 guanidines Chemical class 0.000 claims 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 1
- 150000002540 isothiocyanates Chemical class 0.000 claims 1
- 125000000896 monocarboxylic acid group Chemical group 0.000 claims 1
- 230000003647 oxidation Effects 0.000 claims 1
- 238000007254 oxidation reaction Methods 0.000 claims 1
- 238000007248 oxidative elimination reaction Methods 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- RLOWWWKZYUNIDI-UHFFFAOYSA-N phosphinic chloride Chemical compound ClP=O RLOWWWKZYUNIDI-UHFFFAOYSA-N 0.000 claims 1
- 229920000768 polyamine Polymers 0.000 claims 1
- 238000006268 reductive amination reaction Methods 0.000 claims 1
- 125000001424 substituent group Chemical group 0.000 claims 1
- UMGDCJDMYOKAJW-UHFFFAOYSA-N thiourea Chemical compound NC(N)=S UMGDCJDMYOKAJW-UHFFFAOYSA-N 0.000 claims 1
- GKASDNZWUGIAMG-UHFFFAOYSA-N triethyl orthoformate Chemical compound CCOC(OCC)OCC GKASDNZWUGIAMG-UHFFFAOYSA-N 0.000 claims 1
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 claims 1
- YIOSBVGXNFWVER-UHFFFAOYSA-N O=C1N(CCC2)C2=NC=C1 Chemical compound O=C1N(CCC2)C2=NC=C1 YIOSBVGXNFWVER-UHFFFAOYSA-N 0.000 description 1
- SMAJDYLFGHWYFO-UHFFFAOYSA-N O=C1N(CCC2)C2NC=C1 Chemical compound O=C1N(CCC2)C2NC=C1 SMAJDYLFGHWYFO-UHFFFAOYSA-N 0.000 description 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2019230768A JP6951406B2 (ja) | 2014-07-04 | 2019-12-20 | フラバグリン誘導体 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR1456474 | 2014-07-04 | ||
| FR1456474A FR3023290B1 (fr) | 2014-07-04 | 2014-07-04 | Derives de flavaglines |
| PCT/EP2015/065294 WO2016001441A1 (fr) | 2014-07-04 | 2015-07-06 | Dérivés de flavaglines |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019230768A Division JP6951406B2 (ja) | 2014-07-04 | 2019-12-20 | フラバグリン誘導体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017519796A JP2017519796A (ja) | 2017-07-20 |
| JP2017519796A5 true JP2017519796A5 (cg-RX-API-DMAC10.html) | 2018-08-16 |
| JP6637954B2 JP6637954B2 (ja) | 2020-01-29 |
Family
ID=52016681
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017500083A Active JP6637954B2 (ja) | 2014-07-04 | 2015-07-06 | フラバグリン誘導体 |
| JP2019230768A Active JP6951406B2 (ja) | 2014-07-04 | 2019-12-20 | フラバグリン誘導体 |
| JP2021154798A Active JP7340574B2 (ja) | 2014-07-04 | 2021-09-22 | フラバグリン誘導体 |
| JP2023137552A Pending JP2023159393A (ja) | 2014-07-04 | 2023-08-25 | フラバグリン誘導体 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019230768A Active JP6951406B2 (ja) | 2014-07-04 | 2019-12-20 | フラバグリン誘導体 |
| JP2021154798A Active JP7340574B2 (ja) | 2014-07-04 | 2021-09-22 | フラバグリン誘導体 |
| JP2023137552A Pending JP2023159393A (ja) | 2014-07-04 | 2023-08-25 | フラバグリン誘導体 |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US10047064B2 (cg-RX-API-DMAC10.html) |
| EP (3) | EP3418273B1 (cg-RX-API-DMAC10.html) |
| JP (4) | JP6637954B2 (cg-RX-API-DMAC10.html) |
| DK (2) | DK3164393T3 (cg-RX-API-DMAC10.html) |
| ES (2) | ES2908225T3 (cg-RX-API-DMAC10.html) |
| FR (1) | FR3023290B1 (cg-RX-API-DMAC10.html) |
| PL (2) | PL3164393T3 (cg-RX-API-DMAC10.html) |
| TR (1) | TR201819805T4 (cg-RX-API-DMAC10.html) |
| WO (1) | WO2016001441A1 (cg-RX-API-DMAC10.html) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR3023290B1 (fr) * | 2014-07-04 | 2016-08-19 | Pf Medicament | Derives de flavaglines |
| WO2017091585A1 (en) | 2015-11-25 | 2017-06-01 | Effector Therapeutics, Inc. | Eif4-a-inhibiting compounds and methods related thereto |
| PT3643707T (pt) * | 2017-06-19 | 2022-05-04 | Futurechem Co Ltd | Composto marcado com 18f para o diagnóstico do cancro da próstata e a respetiva utilização |
| CN112351977A (zh) * | 2018-02-19 | 2021-02-09 | 纪念斯隆凯特林癌症中心 | 治疗异常增殖性疾病的药剂和方法 |
| JP7402172B2 (ja) | 2018-04-10 | 2023-12-20 | セレクター・バイオサイエンシズ・インコーポレイテッド | リン脂質－フラバグリン複合体およびそれを標的癌治療に使用する方法 |
| US12403121B2 (en) * | 2018-10-09 | 2025-09-02 | The Research Institute At Nationwide Children's Hospital | Anticancer rocaglamide derivatives |
| WO2020086562A1 (en) * | 2018-10-22 | 2020-04-30 | Trustees Of Boston University | Compositions and methods for inhibiting viral infection |
| AU2020361679A1 (en) * | 2019-10-10 | 2022-04-28 | Cellectar Biosciences, Inc. | Phospholipid-flavagline conjugates and methods of using the same for targeted cancer therapy |
| WO2025104293A1 (en) * | 2023-11-17 | 2025-05-22 | Gustave Roussy Transfert | Inhibitors of eif4a and uses thereof |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AUPQ866500A0 (en) * | 2000-07-05 | 2000-08-03 | Exgenix Operations Pty Ltd | Therapeutic compounds and methods |
| DE102004024504A1 (de) | 2004-05-18 | 2006-02-16 | Bayer Healthcare Ag | Neue Cylopenta[b]benzofuran-Derivate und ihre Verwendung |
| CA2652873A1 (en) * | 2006-05-22 | 2007-12-06 | Trustees Of Boston University | Asymmetric synthesis of rocaglamides via enantioselective photocycloaddition mediated by chiral bronsted acids |
| EP2189453A1 (en) * | 2008-11-25 | 2010-05-26 | Université Louis Pasteur | Rocaglaol derivatives as cardioprotectant agents |
| KR20110096566A (ko) * | 2008-12-05 | 2011-08-30 | 인터메드 디스커버리 게엠베하 | Ｈｉｆ-1 단백질 축적의 억제제 |
| FR3023290B1 (fr) * | 2014-07-04 | 2016-08-19 | Pf Medicament | Derives de flavaglines |
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2014
- 2014-07-04 FR FR1456474A patent/FR3023290B1/fr active Active
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2015
- 2015-07-06 ES ES18187037T patent/ES2908225T3/es active Active
- 2015-07-06 PL PL15733767T patent/PL3164393T3/pl unknown
- 2015-07-06 JP JP2017500083A patent/JP6637954B2/ja active Active
- 2015-07-06 ES ES15733767T patent/ES2700156T3/es active Active
- 2015-07-06 US US15/323,650 patent/US10047064B2/en active Active
- 2015-07-06 EP EP18187037.9A patent/EP3418273B1/fr active Active
- 2015-07-06 EP EP21213303.7A patent/EP3998257A1/fr active Pending
- 2015-07-06 DK DK15733767.6T patent/DK3164393T3/en active
- 2015-07-06 EP EP15733767.6A patent/EP3164393B1/fr active Active
- 2015-07-06 TR TR2018/19805T patent/TR201819805T4/tr unknown
- 2015-07-06 WO PCT/EP2015/065294 patent/WO2016001441A1/fr not_active Ceased
- 2015-07-06 DK DK18187037.9T patent/DK3418273T3/da active
- 2015-07-06 PL PL18187037.9T patent/PL3418273T3/pl unknown
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2017
- 2017-12-01 US US15/829,630 patent/US10519125B2/en active Active
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2019
- 2019-12-20 JP JP2019230768A patent/JP6951406B2/ja active Active
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2021
- 2021-09-22 JP JP2021154798A patent/JP7340574B2/ja active Active
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2023
- 2023-08-25 JP JP2023137552A patent/JP2023159393A/ja active Pending