JP2020063289A5 - - Google Patents
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- Publication number
- JP2020063289A5 JP2020063289A5 JP2019230768A JP2019230768A JP2020063289A5 JP 2020063289 A5 JP2020063289 A5 JP 2020063289A5 JP 2019230768 A JP2019230768 A JP 2019230768A JP 2019230768 A JP2019230768 A JP 2019230768A JP 2020063289 A5 JP2020063289 A5 JP 2020063289A5
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- JP
- Japan
- Prior art keywords
- compound
- formula
- alkyl
- group
- aryl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 150000001875 compounds Chemical class 0.000 claims 43
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 14
- 125000002485 formyl group Chemical group [H]C(*)=O 0.000 claims 9
- 125000003118 aryl group Chemical group 0.000 claims 7
- 238000000034 method Methods 0.000 claims 6
- 125000000623 heterocyclic group Chemical group 0.000 claims 5
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 claims 4
- 125000002877 alkyl aryl group Chemical group 0.000 claims 4
- 229910052757 nitrogen Inorganic materials 0.000 claims 4
- 125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims 3
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 3
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 3
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 claims 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical group N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 2
- 150000001412 amines Chemical class 0.000 claims 2
- 125000004432 carbon atom Chemical group C* 0.000 claims 2
- 125000000524 functional group Chemical group 0.000 claims 2
- 125000005843 halogen group Chemical group 0.000 claims 2
- 125000005842 heteroatom Chemical group 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims 2
- 238000006722 reduction reaction Methods 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 229920006395 saturated elastomer Polymers 0.000 claims 2
- 239000012453 solvate Substances 0.000 claims 2
- 238000006467 substitution reaction Methods 0.000 claims 2
- 206010028980 Neoplasm Diseases 0.000 claims 1
- YZCKVEUIGOORGS-IGMARMGPSA-N Protium Chemical compound [1H] YZCKVEUIGOORGS-IGMARMGPSA-N 0.000 claims 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims 1
- 229910052783 alkali metal Inorganic materials 0.000 claims 1
- 150000001340 alkali metals Chemical class 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 claims 1
- 150000004945 aromatic hydrocarbons Chemical class 0.000 claims 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 1
- IVRMZWNICZWHMI-UHFFFAOYSA-N azide group Chemical group [N-]=[N+]=[N-] IVRMZWNICZWHMI-UHFFFAOYSA-N 0.000 claims 1
- 150000001540 azides Chemical class 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 125000006297 carbonyl amino group Chemical group [H]N([*:2])C([*:1])=O 0.000 claims 1
- 150000001732 carboxylic acid derivatives Chemical group 0.000 claims 1
- 238000006243 chemical reaction Methods 0.000 claims 1
- 238000005906 dihydroxylation reaction Methods 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 230000003647 oxidation Effects 0.000 claims 1
- 238000007254 oxidation reaction Methods 0.000 claims 1
- 238000007248 oxidative elimination reaction Methods 0.000 claims 1
- 229910052760 oxygen Inorganic materials 0.000 claims 1
- 239000001301 oxygen Substances 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
- 238000006268 reductive amination reaction Methods 0.000 claims 1
- 125000001424 substituent group Chemical group 0.000 claims 1
- 229910052717 sulfur Chemical group 0.000 claims 1
- 239000011593 sulfur Chemical group 0.000 claims 1
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 claims 1
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021154798A JP7340574B2 (ja) | 2014-07-04 | 2021-09-22 | フラバグリン誘導体 |
| JP2023137552A JP2023159393A (ja) | 2014-07-04 | 2023-08-25 | フラバグリン誘導体 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR1456474A FR3023290B1 (fr) | 2014-07-04 | 2014-07-04 | Derives de flavaglines |
| FR1456474 | 2014-07-04 | ||
| JP2017500083A JP6637954B2 (ja) | 2014-07-04 | 2015-07-06 | フラバグリン誘導体 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017500083A Division JP6637954B2 (ja) | 2014-07-04 | 2015-07-06 | フラバグリン誘導体 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021154798A Division JP7340574B2 (ja) | 2014-07-04 | 2021-09-22 | フラバグリン誘導体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020063289A JP2020063289A (ja) | 2020-04-23 |
| JP2020063289A5 true JP2020063289A5 (cg-RX-API-DMAC10.html) | 2020-07-27 |
| JP6951406B2 JP6951406B2 (ja) | 2021-10-20 |
Family
ID=52016681
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017500083A Active JP6637954B2 (ja) | 2014-07-04 | 2015-07-06 | フラバグリン誘導体 |
| JP2019230768A Active JP6951406B2 (ja) | 2014-07-04 | 2019-12-20 | フラバグリン誘導体 |
| JP2021154798A Active JP7340574B2 (ja) | 2014-07-04 | 2021-09-22 | フラバグリン誘導体 |
| JP2023137552A Pending JP2023159393A (ja) | 2014-07-04 | 2023-08-25 | フラバグリン誘導体 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017500083A Active JP6637954B2 (ja) | 2014-07-04 | 2015-07-06 | フラバグリン誘導体 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021154798A Active JP7340574B2 (ja) | 2014-07-04 | 2021-09-22 | フラバグリン誘導体 |
| JP2023137552A Pending JP2023159393A (ja) | 2014-07-04 | 2023-08-25 | フラバグリン誘導体 |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US10047064B2 (cg-RX-API-DMAC10.html) |
| EP (3) | EP3164393B1 (cg-RX-API-DMAC10.html) |
| JP (4) | JP6637954B2 (cg-RX-API-DMAC10.html) |
| DK (2) | DK3418273T3 (cg-RX-API-DMAC10.html) |
| ES (2) | ES2700156T3 (cg-RX-API-DMAC10.html) |
| FR (1) | FR3023290B1 (cg-RX-API-DMAC10.html) |
| PL (2) | PL3164393T3 (cg-RX-API-DMAC10.html) |
| TR (1) | TR201819805T4 (cg-RX-API-DMAC10.html) |
| WO (1) | WO2016001441A1 (cg-RX-API-DMAC10.html) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR3023290B1 (fr) * | 2014-07-04 | 2016-08-19 | Pf Medicament | Derives de flavaglines |
| ES2974439T3 (es) | 2015-11-25 | 2024-06-27 | Effector Therapeutics Inc | Compuestos inhibidores de EIF4-A y métodos relacionados con los mismos |
| CA3067696C (en) * | 2017-06-19 | 2022-05-03 | Futurechem Co., Ltd. | 18f-labelled compound for prostate cancer diagnosis, and use thereof |
| JP2021513963A (ja) * | 2018-02-19 | 2021-06-03 | メモリアル スローン ケタリング キャンサー センター | 異常増殖性疾患を治療するための薬剤および方法 |
| DK3773544T3 (da) | 2018-04-10 | 2025-09-15 | Cellectar Biosciences Inc | Phospholipid-flavaglinkonjugater og fremgangsmåder til anvendelse deraf til målrettet cancerterapi |
| WO2020076889A1 (en) * | 2018-10-09 | 2020-04-16 | The Research Institute At Nationwide Children's Hospital | Anticancer rocaglamide derivatives |
| US11427595B2 (en) * | 2018-10-22 | 2022-08-30 | Trustees Of Boston University | Compositions and methods for inhibiting viral infection |
| WO2021072300A1 (en) | 2019-10-10 | 2021-04-15 | Cellectar Biosciences, Inc. | Phospholipid-flavagline conjugates and methods of using the same for targeted cancer therapy |
| WO2025104293A1 (en) * | 2023-11-17 | 2025-05-22 | Gustave Roussy Transfert | Inhibitors of eif4a and uses thereof |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AUPQ866500A0 (en) * | 2000-07-05 | 2000-08-03 | Exgenix Operations Pty Ltd | Therapeutic compounds and methods |
| DE102004024504A1 (de) | 2004-05-18 | 2006-02-16 | Bayer Healthcare Ag | Neue Cylopenta[b]benzofuran-Derivate und ihre Verwendung |
| CA2652873A1 (en) * | 2006-05-22 | 2007-12-06 | Trustees Of Boston University | Asymmetric synthesis of rocaglamides via enantioselective photocycloaddition mediated by chiral bronsted acids |
| EP2189453A1 (en) * | 2008-11-25 | 2010-05-26 | Université Louis Pasteur | Rocaglaol derivatives as cardioprotectant agents |
| WO2010063471A1 (en) | 2008-12-05 | 2010-06-10 | Intermed Discovery Gmbh | Inhibitors of hif-1 protein accumulation |
| FR3023290B1 (fr) * | 2014-07-04 | 2016-08-19 | Pf Medicament | Derives de flavaglines |
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2014
- 2014-07-04 FR FR1456474A patent/FR3023290B1/fr active Active
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2015
- 2015-07-06 TR TR2018/19805T patent/TR201819805T4/tr unknown
- 2015-07-06 DK DK18187037.9T patent/DK3418273T3/da active
- 2015-07-06 DK DK15733767.6T patent/DK3164393T3/en active
- 2015-07-06 JP JP2017500083A patent/JP6637954B2/ja active Active
- 2015-07-06 PL PL15733767T patent/PL3164393T3/pl unknown
- 2015-07-06 EP EP15733767.6A patent/EP3164393B1/fr active Active
- 2015-07-06 EP EP21213303.7A patent/EP3998257A1/fr active Pending
- 2015-07-06 ES ES15733767T patent/ES2700156T3/es active Active
- 2015-07-06 EP EP18187037.9A patent/EP3418273B1/fr active Active
- 2015-07-06 ES ES18187037T patent/ES2908225T3/es active Active
- 2015-07-06 WO PCT/EP2015/065294 patent/WO2016001441A1/fr not_active Ceased
- 2015-07-06 PL PL18187037.9T patent/PL3418273T3/pl unknown
- 2015-07-06 US US15/323,650 patent/US10047064B2/en active Active
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2017
- 2017-12-01 US US15/829,630 patent/US10519125B2/en active Active
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2019
- 2019-12-20 JP JP2019230768A patent/JP6951406B2/ja active Active
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2021
- 2021-09-22 JP JP2021154798A patent/JP7340574B2/ja active Active
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2023
- 2023-08-25 JP JP2023137552A patent/JP2023159393A/ja active Pending