PE20121314A1 - Derivados de 4-aminociclohexano sustituido - Google Patents
Derivados de 4-aminociclohexano sustituidoInfo
- Publication number
- PE20121314A1 PE20121314A1 PE2012000622A PE2012000622A PE20121314A1 PE 20121314 A1 PE20121314 A1 PE 20121314A1 PE 2012000622 A PE2012000622 A PE 2012000622A PE 2012000622 A PE2012000622 A PE 2012000622A PE 20121314 A1 PE20121314 A1 PE 20121314A1
- Authority
- PE
- Peru
- Prior art keywords
- methyl
- indol
- phenyl
- cyclohexil
- methanone
- Prior art date
Links
Classifications
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D209/20—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals substituted additionally by nitrogen atoms, e.g. tryptophane
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- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
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- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/136—Amines having aromatic rings, e.g. ketamine, nortriptyline having the amino group directly attached to the aromatic ring, e.g. benzeneamine
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- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
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- A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
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- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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Abstract
REFERIDA A UN DERIVADO 4-AMINOCICLOHEXANO DE FORMULA (1), DONDE Y1, Y1', Y2, Y2', Y3, Y3', Y4 E Y4' SON H, F, Cl, Br, NO2, CN, ENTRE OTROS; R1 Y R2 SON H, R0 O JUNTOS FORMAN -CH2CH2OCH2CH2-, -CH2CH2NR4CH2CH2- O -(CH2)3-6; R0 ES UN GRUPO ALIFATICO C1-C8, ARILO, HETEROARILO, ENTRE OTROS; R3 ES R0; R4 ES H, R0, C(=O)R0; n ES UN ENTERO DE 0 A 12; X ES O, S, NRA; RA ES H, R0, C(=O)R0, C(=O)NH2, ENTRE OTROS; RB ES H, R0, C(=O)H, C(=O)OH, ENTRE OTROS; Q ES R0, C(=O)R0, C(=O)OR0, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: 1-(IMINO(1-METIL-1H-INDOL-2-IL)METIL)-N1,N1,N4,N4-TETRAMETIL-4-FENILCICLOHEXANO-1,4-DIAMINA,BIS(2-HIDROXIPROPANO-1,2,3-TRICARBOXILATO), 4-(DIMETILAMINO)-4-FENIL-1-(PIRROLIDIN-1-IL)CICLOHEXIL)-(1-METIL-1H-INDOL-2-IL)METANONA, 1,4-BIS(DIMETILAMINO)-4-FENILCICLOHEXIL)(1-METIL-1H-INDOL-2-IL)METANONA, ENTRE OTROS. TAMBIEN ESTA REFERIDA A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS TIENEN AFINIDAD POR EL RECEPTOR OPIOIDE MU Y EL RECEPTOR ORL-1 Y SON UTILES EN EL TRATAMIENTO DEL DOLOR
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MX2010010339A (es) | 2008-03-27 | 2010-10-07 | Gruenenthal Gmbh | Ciclohexildiaminas sustituidas. |
CL2009000732A1 (es) | 2008-03-27 | 2009-05-15 | Gruenethal Gmbh | Compuestos derivados de hidroximetil ciclohexilaminas sustituidos; composicion farmaceutica que contiene a dicho compuesto y sus uso como moduladores del receptor de opiodes u y el receptor orl-1 para tratar el dolor, ansiedad, depresion, epilepsia, alzheimer, abuso del alcohol, hipertension, anorexia, obesidad y diarrea. |
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CL2009000733A1 (es) * | 2008-03-27 | 2009-05-15 | Gruenenthal Chemie | Compuestos derivados de (hetero) aril-ciclohexano sustituidos, composicion farmaceutica que contiene a dicho compuesto y su uso como moduladores del receptor de opioides µ y el receptor orl-1 para tratar el dolor, ansiedad, depresion, epilepsia, alzheimer, demencia senil, sintomas de abstinencia, abuso de alcohol. |
BRPI0909527A2 (pt) | 2008-03-27 | 2019-09-24 | Gruenenthal Gmbh | derivados substituídos de 4-aminociclohexano |
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