|
US4873191A
(en)
|
1981-06-12 |
1989-10-10 |
Ohio University |
Genetic transformation of zygotes
|
|
NZ207394A
(en)
|
1983-03-08 |
1987-03-06 |
Commw Serum Lab Commission |
Detecting or determining sequence of amino acids
|
|
EP0273085A1
(en)
|
1986-12-29 |
1988-07-06 |
IntraCel Corporation |
A method for internalizing nucleic acids into eukaryotic cells
|
|
US6867195B1
(en)
|
1989-03-21 |
2005-03-15 |
Vical Incorporated |
Lipid-mediated polynucleotide administration to reduce likelihood of subject's becoming infected
|
|
TW215434B
(https=)
|
1992-03-07 |
1993-11-01 |
Hoechst Ag |
|
|
JP4285766B2
(ja)
|
1994-03-23 |
2009-06-24 |
オハイオ ユニバーシティ |
緻密にした核酸および細胞へのデリバリ
|
|
US5972901A
(en)
|
1994-03-23 |
1999-10-26 |
Case Western Reserve University |
Serpin enzyme complex receptor--mediated gene transfer
|
|
US6077835A
(en)
|
1994-03-23 |
2000-06-20 |
Case Western Reserve University |
Delivery of compacted nucleic acid to cells
|
|
US5844107A
(en)
|
1994-03-23 |
1998-12-01 |
Case Western Reserve University |
Compacted nucleic acids and their delivery to cells
|
|
US6040296A
(en)
|
1995-06-07 |
2000-03-21 |
East Carolina University |
Specific antisense oligonucleotide composition & method for treatment of disorders associated with bronchoconstriction and lung inflammation
|
|
US7034007B1
(en)
|
1995-06-07 |
2006-04-25 |
East Carolina University |
Low adenosine anti-sense oligonucleotide, compositions, kit & method for treatment of airway disorders associated with bronchoconstriction, lung inflammation, allergy(ies) & surfactant depletion
|
|
US6825174B2
(en)
|
1995-06-07 |
2004-11-30 |
East Carolina University |
Composition, formulations & method for prevention & treatment of diseases and conditions associated with bronchoconstriction, allergy(ies) & inflammation
|
|
US6025339A
(en)
|
1995-06-07 |
2000-02-15 |
East Carolina University |
Composition, kit and method for treatment of disorders associated with bronchoconstriction and lung inflammation
|
|
US5994315A
(en)
|
1995-06-07 |
1999-11-30 |
East Carolina University |
Low adenosine agent, composition, kit and method for treatment of airway disease
|
|
WO1999013886A1
(en)
|
1997-09-17 |
1999-03-25 |
East Carolina University |
Multiple target hybridizing nucleic acids, their preparation, compositions, formulation, kits and applications
|
|
EP1011608A4
(en)
|
1998-06-08 |
2002-05-15 |
Epigenesis Pharmaceuticals Inc |
COMPOSITION AND METHOD FOR THE PREVENTION AND TREATMENT OF HEART AND NEUTRAL FAILURE OR DAMAGE RELATED TO ISCHEMIA, ENDOTOXIN RELEASE, ARDS OR CALLED BY THE ADDITION OF SPECIFIC MEDICINES
|
|
US20050014711A1
(en)
|
1998-06-09 |
2005-01-20 |
Nyce Jonathan W. |
Composition, formulations & methods for prevention and treatment of diseases and conditions associated with bronchoconstriction, allergy(ies) and inflammation
|
|
US20020042388A1
(en)
|
2001-05-01 |
2002-04-11 |
Cooper Mark J. |
Lyophilizable and enhanced compacted nucleic acids
|
|
WO2002032396A2
(en)
|
2000-10-16 |
2002-04-25 |
Massachusetts Institute Of Technology |
Lipid-protein-sugar particles for delivery of nucleic acids
|
|
US20040259247A1
(en)
*
|
2000-12-01 |
2004-12-23 |
Thomas Tuschl |
Rna interference mediating small rna molecules
|
|
JP2004535388A
(ja)
|
2001-04-30 |
2004-11-25 |
ターゲティッド ジェネティクス コーポレイション |
脂質含有薬物送達複合体およびそれらの生成方法
|
|
US7229774B2
(en)
|
2001-08-02 |
2007-06-12 |
Regents Of The University Of Michigan |
Expression profile of prostate cancer
|
|
EP2390331B1
(en)
|
2001-09-28 |
2018-04-25 |
Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. |
MicroRNA molecules
|
|
US7851150B2
(en)
|
2002-12-18 |
2010-12-14 |
Third Wave Technologies, Inc. |
Detection of small nucleic acids
|
|
CA2941594C
(en)
|
2002-12-20 |
2021-07-06 |
Celera Corporation |
Genetic polymorphisms of the protein receptor c (procr) associated with myocardial infarction, methods of detection and uses thereof
|
|
JP2006519008A
(ja)
|
2003-02-10 |
2006-08-24 |
独立行政法人産業技術総合研究所 |
哺乳動物細胞の調節
|
|
US7750144B2
(en)
|
2003-06-02 |
2010-07-06 |
University Of Massachusetts |
Methods and compositions for enhancing the efficacy and specificity of RNA silencing
|
|
US7683036B2
(en)
|
2003-07-31 |
2010-03-23 |
Regulus Therapeutics Inc. |
Oligomeric compounds and compositions for use in modulation of small non-coding RNAs
|
|
US7776569B2
(en)
|
2003-08-22 |
2010-08-17 |
University Of Massachusetts |
Virally-encoded RNAs as substrates, inhibitors and delivery vehicles for RNAi
|
|
US20080045417A1
(en)
|
2003-10-14 |
2008-02-21 |
Jan Weiler |
Oligonucleotide Microarray
|
|
EP2295604B1
(en)
*
|
2004-02-09 |
2015-04-08 |
Thomas Jefferson University |
Diagnosis and treatment of cancers with microRNA located in or near cancer-associated chromosomal features
|
|
US20050182005A1
(en)
*
|
2004-02-13 |
2005-08-18 |
Tuschl Thomas H. |
Anti-microRNA oligonucleotide molecules
|
|
EP1723162A4
(en)
|
2004-02-13 |
2010-05-05 |
Univ Rockefeller |
ANTI-microRNA oligonucleotide molecules
|
|
US20070258949A1
(en)
|
2004-03-01 |
2007-11-08 |
Five Prime Therapeutics, Inc. |
Human Cdna Clones Comprising Polynucleotides Encoding Polypeptides and Methods of Their Use
|
|
US20050260648A1
(en)
|
2004-04-06 |
2005-11-24 |
Huffel Christophe V |
Method for the determination of cellular transcriptional
|
|
US20060134639A1
(en)
|
2004-04-06 |
2006-06-22 |
Huffel Christophe V |
Method for the determination of cellular transcriptional regulation
|
|
CN101056991A
(zh)
|
2004-04-20 |
2007-10-17 |
基因耐克生物医学制品有限公司 |
检测ncRNA的方法
|
|
AU2005243187A1
(en)
|
2004-05-11 |
2005-11-24 |
Wyeth |
Oligonucleotide arrays to monitor gene expression and methods for making and using same
|
|
CA2566519C
(en)
|
2004-05-14 |
2020-04-21 |
Rosetta Genomics Ltd. |
Micrornas and uses thereof
|
|
EP2290071B1
(en)
*
|
2004-05-28 |
2014-12-31 |
Asuragen, Inc. |
Methods and compositions involving microRNA
|
|
US7575863B2
(en)
|
2004-05-28 |
2009-08-18 |
Applied Biosystems, Llc |
Methods, compositions, and kits comprising linker probes for quantifying polynucleotides
|
|
US7635563B2
(en)
|
2004-06-30 |
2009-12-22 |
Massachusetts Institute Of Technology |
High throughput methods relating to microRNA expression analysis
|
|
WO2006047454A2
(en)
|
2004-10-21 |
2006-05-04 |
Rutgers, The State University Of New Jersey |
Rational probe optimization for detection of micrornas
|
|
CA2857881A1
(en)
|
2004-11-12 |
2006-12-28 |
Asuragen, Inc. |
Methods and compositions involving mirna and mirna inhibitor molecules
|
|
US20060185027A1
(en)
|
2004-12-23 |
2006-08-17 |
David Bartel |
Systems and methods for identifying miRNA targets and for altering miRNA and target expression
|
|
WO2006069584A2
(en)
|
2004-12-29 |
2006-07-06 |
Exiqon A/S |
NOVEL OLIGONUCLEOTIDE COMPOSITIONS AND PROBE SEQUENCES USEFUL FOR DETECTION AND ANALYSIS OF microRNAs AND THEIR TARGET mRNAs
|
|
US20090123912A1
(en)
|
2005-01-25 |
2009-05-14 |
Rosetta Inpharmatics Llc |
Methods for quantitating small RNA molecules
|
|
GB0502042D0
(en)
*
|
2005-02-01 |
2005-03-09 |
Univ Glasgow |
Materials and methods for diagnosis and treatment of chronic fatigue syndrome
|
|
US20070065840A1
(en)
|
2005-03-23 |
2007-03-22 |
Irena Naguibneva |
Novel oligonucleotide compositions and probe sequences useful for detection and analysis of microRNAS and their target mRNAS
|
|
WO2006107826A2
(en)
|
2005-04-04 |
2006-10-12 |
The Board Of Regents Of The University Of Texas System |
Micro-rna's that regulate muscle cells
|
|
JP2006292367A
(ja)
|
2005-04-05 |
2006-10-26 |
Mitsubishi Rayon Co Ltd |
miRNA検出用マイクロアレイ
|
|
EP1874936B1
(en)
|
2005-04-19 |
2013-10-30 |
BASF Plant Science GmbH |
Improved methods controlling gene expression
|
|
EP2631292A3
(en)
|
2005-04-29 |
2013-11-20 |
The Rockefeller University |
Human microRNAs and methods for inhibiting same
|
|
US20060265771A1
(en)
|
2005-05-17 |
2006-11-23 |
Lewis David L |
Monitoring microrna expression and function
|
|
PL2002003T3
(pl)
|
2005-05-27 |
2016-06-30 |
Ospedale San Raffaele Srl |
Wektor genetyczny zawierający mi-RNA
|
|
WO2006133022A2
(en)
|
2005-06-03 |
2006-12-14 |
The Johns Hopkins University |
Compositions and methods for decreasing microrna expression for the treatment of neoplasia
|
|
US20070065844A1
(en)
|
2005-06-08 |
2007-03-22 |
Massachusetts Institute Of Technology |
Solution-based methods for RNA expression profiling
|
|
WO2007002375A2
(en)
|
2005-06-23 |
2007-01-04 |
U.S. Genomics, Inc. |
Methods and compositions for analysis of microrna
|
|
US20070003939A1
(en)
|
2005-07-01 |
2007-01-04 |
Hui Wang |
Melting temperature matching
|
|
JP5489459B2
(ja)
|
2005-08-01 |
2014-05-14 |
ジ・オハイオ・ステイト・ユニバーシティ・リサーチ・ファウンデイション |
乳癌の診断、予後及び治療のためのマイクロrnaに基づいた方法及び組成物
|
|
US20070054872A1
(en)
|
2005-08-24 |
2007-03-08 |
Mirus Bio Corporation |
Regulatable or conditional expression systems
|
|
WO2007028030A2
(en)
|
2005-09-02 |
2007-03-08 |
Picobella, Llc |
Oncogenic regulatory rnas for diagnostics and therapeutics
|
|
CA2845251A1
(en)
|
2005-09-12 |
2007-03-22 |
The Ohio State University Research Foundation |
Compositions for the therapy of bcl2-associated cancers and methods of preparation thereof
|
|
WO2007042899A2
(en)
|
2005-10-10 |
2007-04-19 |
Council Of Scientific And Industrial Research |
Human microrna targets in hiv genome and a method of identification thereof
|
|
US20070092882A1
(en)
|
2005-10-21 |
2007-04-26 |
Hui Wang |
Analysis of microRNA
|
|
PL1969125T3
(pl)
*
|
2005-12-12 |
2012-11-30 |
Univ North Carolina Chapel Hill |
Mikrorna, które regulują proliferację i różnicowanie komórek mięśniowych
|
|
US7390792B2
(en)
|
2005-12-15 |
2008-06-24 |
Board Of Regents, The University Of Texas System |
MicroRNA1 therapies
|
|
EP1966390A1
(en)
|
2005-12-29 |
2008-09-10 |
Exiqon A/S |
Detection of tissue origin of cancer
|
|
JP5490413B2
(ja)
|
2006-01-05 |
2014-05-14 |
ジ・オハイオ・ステイト・ユニバーシティ・リサーチ・ファウンデイション |
膵内分泌腫瘍及び膵腺房腫瘍におけるマイクロrna発現異常
|
|
WO2007081196A1
(en)
|
2006-01-10 |
2007-07-19 |
Koninklijke Nederlandse Akademie Van Wetenschappen |
New nucleic acid molecules and collections thereof, their application and identification
|
|
ES2448491T3
(es)
|
2006-03-02 |
2014-03-14 |
The Ohio State University Research Foundation |
Perfil de expresión de microARN asociado con cáncer de páncreas
|
|
CA2648132C
(en)
|
2006-04-03 |
2019-05-28 |
Santaris Pharma A/S |
Pharmaceutical composition comprising anti-mirna antisense oligonucleotides
|
|
GB2440782A
(en)
|
2006-08-04 |
2008-02-13 |
Cesare Peschle |
Uses and compositions comprising miRNAs
|
|
US20090306181A1
(en)
|
2006-09-29 |
2009-12-10 |
Children's Medical Center Corporation |
Compositions and methods for evaluating and treating heart failure
|
|
EP2489742A1
(de)
|
2006-10-09 |
2012-08-22 |
Julius-Maximilians-Universität Würzburg |
MicroRNA (MIRNA) zur Diagnose und Therapie von Herzerkrankungen
|
|
WO2008147430A2
(en)
|
2006-10-11 |
2008-12-04 |
Nucleonics, Inc. |
Microrna-formatted multitarget interfering rna vector constructs and methods of using the same
|
|
US20100021914A1
(en)
|
2006-11-23 |
2010-01-28 |
Querdenker Aps |
Oligonucleotides for modulating target rna activity
|
|
US8258286B2
(en)
|
2007-04-26 |
2012-09-04 |
University Of Iowa Research Foundation |
Reduction of off-target RNA interference toxicity
|
|
US20090005336A1
(en)
|
2007-05-08 |
2009-01-01 |
Zhiguo Wang |
Use of the microRNA miR-1 for the treatment, prevention, and diagnosis of cardiac conditions
|
|
WO2008147839A1
(en)
|
2007-05-23 |
2008-12-04 |
Dharmacon, Inc. |
Micro-rna scaffolds and non-naturally occurring micro-rnas
|
|
US20090004668A1
(en)
*
|
2007-06-22 |
2009-01-01 |
The Board Of Trustees Of The Leland Stanford Junior University |
Pre-miRNA loop-modulated target regulation
|
|
US20090092980A1
(en)
|
2007-07-20 |
2009-04-09 |
Christoph Arenz |
miRNA PROCESSING INHIBITOR EFFICACY ASSAYS AND SUBSTANCES
|
|
US20100292099A1
(en)
|
2007-08-23 |
2010-11-18 |
Keren Pharmaceutical, Inc. |
Targeting of rna with external guide sequences
|
|
EP2623599B1
(en)
|
2007-10-04 |
2019-01-02 |
Roche Innovation Center Copenhagen A/S |
Micromirs
|
|
CN101424640B
(zh)
|
2007-11-02 |
2012-07-25 |
江苏命码生物科技有限公司 |
血清中微小核糖核酸的检测方法和用于检测的试剂盒、生物芯片及其制作和应用方法
|
|
US20090186414A1
(en)
|
2008-01-18 |
2009-07-23 |
Deepak Srivastava |
Methods of Generating Cardiomyocytes and Cardiac Progenitors and Compositions
|
|
US8188060B2
(en)
|
2008-02-11 |
2012-05-29 |
Dharmacon, Inc. |
Duplex oligonucleotides with enhanced functionality in gene regulation
|
|
WO2009111375A2
(en)
|
2008-03-01 |
2009-09-11 |
Abraxis Bioscience, Llc |
Treatment, diagnostic, and method for discovering antagonist using sparc specific mirnas
|
|
EP2268811A1
(en)
|
2008-03-07 |
2011-01-05 |
Santaris Pharma A/S |
Pharmaceutical compositions for treatment of microrna related diseases
|
|
CA2718520C
(en)
*
|
2008-03-17 |
2020-01-07 |
The Board Of Regents Of The University Of Texas System |
Identification of micro-rnas involved in neuromuscular synapse maintenance and regeneration
|
|
EP2105145A1
(en)
|
2008-03-27 |
2009-09-30 |
ETH Zürich |
Method for muscle-specific delivery lipid-conjugated oligonucleotides
|
|
US8916532B2
(en)
|
2008-04-28 |
2014-12-23 |
The Trustees Of The University Of Pennsylvania |
Methods for enhancing utrophin production via inhibition of microRNA
|
|
CA2726052A1
(en)
|
2008-06-04 |
2009-12-10 |
The Board Of Regents Of The University Of Texas System |
Modulation of gene expression through endogenous small rna targeting of gene promoters
|
|
AU2009257663B2
(en)
|
2008-06-09 |
2014-06-26 |
New York Medical College |
Compositions comprising cardiac stem cells overexpressing specific microRNA and methods of their use in repairing damaged myocardium
|
|
EP2169059A1
(en)
|
2008-09-25 |
2010-03-31 |
Academisch Medisch Centrum bij de Universiteit van Amsterdam |
Means and methods for counteracting, preventing and/or determining fibrosis or a risk of fibrosis
|
|
EP2358398A2
(en)
|
2008-10-24 |
2011-08-24 |
Isis Pharmaceuticals, Inc. |
Oligomeric compounds and methods
|
|
AU2009336191B2
(en)
|
2008-12-18 |
2017-08-24 |
Novo Nordisk A/S |
Extended dicer substrate agents and methods for the specific inhibition of gene expression
|
|
US20100173973A1
(en)
|
2008-12-18 |
2010-07-08 |
Dicerna Pharmaceuticals, Inc. |
Extended dicer substrate agents and methods for the specific inhibition of gene expression
|