CN102036689B - 神经肌肉突触维持和再生中涉及的微小rna的鉴定 - Google Patents
神经肌肉突触维持和再生中涉及的微小rna的鉴定 Download PDFInfo
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- CN102036689B CN102036689B CN200980117899.2A CN200980117899A CN102036689B CN 102036689 B CN102036689 B CN 102036689B CN 200980117899 A CN200980117899 A CN 200980117899A CN 102036689 B CN102036689 B CN 102036689B
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- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
- A01K67/0276—Knock-out vertebrates
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- A61K31/00—Medicinal preparations containing organic active ingredients
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- A61K31/7088—Compounds having three or more nucleosides or nucleotides
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- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
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- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/07—Animals genetically altered by homologous recombination
- A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/105—Murine
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
- A01K2267/035—Animal model for multifactorial diseases
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
- A01K2267/035—Animal model for multifactorial diseases
- A01K2267/0356—Animal model for processes and diseases of the central nervous system, e.g. stress, learning, schizophrenia, pain, epilepsy
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
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- C—CHEMISTRY; METALLURGY
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- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]
- C12N2310/141—MicroRNAs, miRNAs
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2330/00—Production
- C12N2330/10—Production naturally occurring
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
- G01N2500/04—Screening involving studying the effect of compounds C directly on molecule A (e.g. C are potential ligands for a receptor A, or potential substrates for an enzyme A)
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/28—Neurological disorders
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- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
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- Biotechnology (AREA)
- Animal Behavior & Ethology (AREA)
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- Chemical Kinetics & Catalysis (AREA)
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- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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- Animal Husbandry (AREA)
- Physical Education & Sports Medicine (AREA)
- Biodiversity & Conservation Biology (AREA)
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- Diabetes (AREA)
- Pain & Pain Management (AREA)
- Hematology (AREA)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US3726008P | 2008-03-17 | 2008-03-17 | |
| US61/037,260 | 2008-03-17 | ||
| PCT/US2009/037405 WO2009117418A2 (en) | 2008-03-17 | 2009-03-17 | Identification of micro-rnas involved in neuromuscular synapse maintenance and regeneration |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN102036689A CN102036689A (zh) | 2011-04-27 |
| CN102036689B true CN102036689B (zh) | 2014-08-06 |
Family
ID=41091497
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN200980117899.2A Expired - Fee Related CN102036689B (zh) | 2008-03-17 | 2009-03-17 | 神经肌肉突触维持和再生中涉及的微小rna的鉴定 |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US8202848B2 (https=) |
| EP (1) | EP2265291B1 (https=) |
| JP (2) | JP5653899B2 (https=) |
| CN (1) | CN102036689B (https=) |
| CA (1) | CA2718520C (https=) |
| WO (1) | WO2009117418A2 (https=) |
Families Citing this family (40)
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| EP2265291B1 (en) * | 2008-03-17 | 2016-10-19 | The Board of Regents of The University of Texas System | Identification of micro-rnas involved in neuromuscular synapse maintenance and regeneration |
| ES2554765T3 (es) | 2008-12-05 | 2015-12-23 | Yeda Research And Development Co. Ltd. | miRNA-9 o miRNA-9* para uso en el tratamiento de ELA |
| US8955215B2 (en) | 2009-05-28 | 2015-02-17 | Hsio Technologies, Llc | High performance surface mount electrical interconnect |
| US9276336B2 (en) | 2009-05-28 | 2016-03-01 | Hsio Technologies, Llc | Metalized pad to electrical contact interface |
| WO2011153298A1 (en) | 2010-06-03 | 2011-12-08 | Hsio Technologies, Llc | Electrical connector insulator housing |
| WO2010141295A1 (en) | 2009-06-02 | 2010-12-09 | Hsio Technologies, Llc | Compliant printed flexible circuit |
| US9196980B2 (en) | 2009-06-02 | 2015-11-24 | Hsio Technologies, Llc | High performance surface mount electrical interconnect with external biased normal force loading |
| US8987886B2 (en) | 2009-06-02 | 2015-03-24 | Hsio Technologies, Llc | Copper pillar full metal via electrical circuit structure |
| WO2010141313A1 (en) | 2009-06-02 | 2010-12-09 | Hsio Technologies, Llc | Compliant printed circuit socket diagnostic tool |
| WO2012074963A1 (en) | 2010-12-01 | 2012-06-07 | Hsio Technologies, Llc | High performance surface mount electrical interconnect |
| WO2010141266A1 (en) | 2009-06-02 | 2010-12-09 | Hsio Technologies, Llc | Compliant printed circuit peripheral lead semiconductor package |
| WO2010141311A1 (en) | 2009-06-02 | 2010-12-09 | Hsio Technologies, Llc | Compliant printed circuit area array semiconductor device package |
| WO2010141264A1 (en) | 2009-06-03 | 2010-12-09 | Hsio Technologies, Llc | Compliant wafer level probe assembly |
| US9277654B2 (en) | 2009-06-02 | 2016-03-01 | Hsio Technologies, Llc | Composite polymer-metal electrical contacts |
| US9613841B2 (en) | 2009-06-02 | 2017-04-04 | Hsio Technologies, Llc | Area array semiconductor device package interconnect structure with optional package-to-package or flexible circuit to package connection |
| WO2010141297A1 (en) | 2009-06-02 | 2010-12-09 | Hsio Technologies, Llc | Compliant printed circuit wafer level semiconductor package |
| US8970031B2 (en) | 2009-06-16 | 2015-03-03 | Hsio Technologies, Llc | Semiconductor die terminal |
| US8789272B2 (en) | 2009-06-02 | 2014-07-29 | Hsio Technologies, Llc | Method of making a compliant printed circuit peripheral lead semiconductor test socket |
| US8988093B2 (en) | 2009-06-02 | 2015-03-24 | Hsio Technologies, Llc | Bumped semiconductor wafer or die level electrical interconnect |
| WO2010141316A1 (en) | 2009-06-02 | 2010-12-09 | Hsio Technologies, Llc | Compliant printed circuit wafer probe diagnostic tool |
| US9320144B2 (en) | 2009-06-17 | 2016-04-19 | Hsio Technologies, Llc | Method of forming a semiconductor socket |
| US8984748B2 (en) | 2009-06-29 | 2015-03-24 | Hsio Technologies, Llc | Singulated semiconductor device separable electrical interconnect |
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| US8758067B2 (en) | 2010-06-03 | 2014-06-24 | Hsio Technologies, Llc | Selective metalization of electrical connector or socket housing |
| KR101235256B1 (ko) * | 2010-09-13 | 2013-02-21 | 서울대학교산학협력단 | miRNA를 타겟으로 한 신경퇴행성 질환 치료 |
| US10184151B2 (en) * | 2011-10-11 | 2019-01-22 | The Brigham And Women's Hospital, Inc. | Micrornas in neurodegenerative disorders |
| JP6340366B2 (ja) | 2012-07-31 | 2018-06-06 | イェダ リサーチ アンド デベロップメント カンパニー リミテッド | 運動ニューロン疾患を診断および処置する方法 |
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| KR101566586B1 (ko) * | 2013-08-21 | 2015-11-16 | 서울대학교산학협력단 | miRNA를 표적으로 하는 뇌전증 또는 발작 관련 질환의 예방 또는 치료용 약학 조성물 및 방법 |
| US20180064748A1 (en) | 2015-03-27 | 2018-03-08 | Yeda Research And Development Co. Ltd. | Methods of treating motor neuron diseases |
| JP6666002B2 (ja) * | 2015-10-07 | 2020-03-13 | 国立大学法人京都大学 | Tdp−43プロテノパシーの予防又は治療用組成物 |
| KR102177130B1 (ko) | 2017-08-18 | 2020-11-10 | (주)큐라미스 | 근육 질환 및 신경근육 질환 예방, 치료 또는 진단을 위한 miR-18b의 용도 |
| EP3773606A4 (en) | 2018-04-03 | 2021-12-08 | Academia Sinica | MIR-17 ~ 92 USEFUL AS A THERAPEUTIC OR DIAGNOSTIC TARGET FOR DEGENERATING DISEASES OF MOTOR MOTORCYCLES (MN) |
| CN108690846A (zh) * | 2018-04-17 | 2018-10-23 | 上海大学 | 抑制MiR-29b基因表达的应用 |
| CN110538192A (zh) * | 2018-05-29 | 2019-12-06 | 中国科学院深圳先进技术研究院 | 一种HDAC4信号通路miRNA抑制剂及其过表达方法和应用 |
| CN110468202A (zh) * | 2019-01-18 | 2019-11-19 | 宁夏医科大学 | 一种靶向TIGIT的miR-206作为肝癌诊断和治疗新型分子的用途 |
| US10844380B1 (en) | 2019-06-17 | 2020-11-24 | Biorchestra Co., Ltd. | Uses for prevention or treatment of brain diseases using microrna |
| US11198908B2 (en) | 2019-06-17 | 2021-12-14 | Biorchestra Co., Ltd. | Method for diagnosis of Alzheimer's disease using microRNA |
| JP2024506869A (ja) * | 2021-02-05 | 2024-02-15 | バイオーケストラ カンパニー, リミテッド | Nlrp3発現の異常に関連する疾患または障害を治療するためのmirna-485阻害剤の使用 |
| CN116981484A (zh) * | 2021-02-05 | 2023-10-31 | 生物欧赛加有限责任公司 | miRNA-485抑制剂调控PSD95、突触素和半胱天冬酶3表达的用途 |
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| US20090246136A1 (en) | 2009-10-01 |
| US8202848B2 (en) | 2012-06-19 |
| US20130030035A1 (en) | 2013-01-31 |
| WO2009117418A2 (en) | 2009-09-24 |
| JP5922721B2 (ja) | 2016-05-24 |
| EP2265291A2 (en) | 2010-12-29 |
| CA2718520A1 (en) | 2009-09-24 |
| CN102036689A (zh) | 2011-04-27 |
| CA2718520C (en) | 2020-01-07 |
| EP2265291B1 (en) | 2016-10-19 |
| JP2014237689A (ja) | 2014-12-18 |
| JP2011515407A (ja) | 2011-05-19 |
| WO2009117418A3 (en) | 2009-12-10 |
| US8728724B2 (en) | 2014-05-20 |
| JP5653899B2 (ja) | 2015-01-14 |
| EP2265291A4 (en) | 2012-09-12 |
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