JP2011515357A - 合成ホスホジエステルオリゴヌクレオチド及びその治療的使用 - Google Patents

合成ホスホジエステルオリゴヌクレオチド及びその治療的使用 Download PDF

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JP2011515357A
JP2011515357A JP2011500164A JP2011500164A JP2011515357A JP 2011515357 A JP2011515357 A JP 2011515357A JP 2011500164 A JP2011500164 A JP 2011500164A JP 2011500164 A JP2011500164 A JP 2011500164A JP 2011515357 A JP2011515357 A JP 2011515357A
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oligonucleotide
bases
mixture
length
sequence
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JP2011515357A5 (enExample
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サイ ステイン,アーロン
イアコベッリ,マッシモ
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ゲンチウム エスピーエー
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088Compounds having three or more nucleosides or nucleotides
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/117Nucleic acids having immunomodulatory properties, e.g. containing CpG-motifs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/10Type of nucleic acid
    • C12N2310/17Immunomodulatory nucleic acids
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2320/00Applications; Uses
    • C12N2320/30Special therapeutic applications
    • C12N2320/31Combination therapy

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Cardiology (AREA)
  • Plant Pathology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Diabetes (AREA)
  • Biochemistry (AREA)
  • Hematology (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2011500164A 2008-03-19 2009-03-13 合成ホスホジエステルオリゴヌクレオチド及びその治療的使用 Pending JP2011515357A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP08425175A EP2103689A1 (en) 2008-03-19 2008-03-19 Synthetic phosphodiester oligonucleotides and therapeutical uses thereof
EP08425175.0 2008-03-19
US5108808P 2008-05-07 2008-05-07
US61/051,088 2008-05-07
PCT/EP2009/053002 WO2009115465A1 (en) 2008-03-19 2009-03-13 Synthetic phosphodiester oligonucleotides and therapeutical uses thereof

Publications (2)

Publication Number Publication Date
JP2011515357A true JP2011515357A (ja) 2011-05-19
JP2011515357A5 JP2011515357A5 (enExample) 2012-04-12

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JP2011500164A Pending JP2011515357A (ja) 2008-03-19 2009-03-13 合成ホスホジエステルオリゴヌクレオチド及びその治療的使用

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US (1) US20110092576A1 (enExample)
EP (2) EP2103689A1 (enExample)
JP (1) JP2011515357A (enExample)
KR (1) KR20100124820A (enExample)
CN (2) CN106361763A (enExample)
AU (1) AU2009226906B2 (enExample)
CA (1) CA2712705C (enExample)
DK (1) DK2252688T3 (enExample)
ES (1) ES2647772T3 (enExample)
IL (1) IL207032A (enExample)
WO (1) WO2009115465A1 (enExample)

Families Citing this family (9)

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Publication number Priority date Publication date Assignee Title
AU2010363814B2 (en) * 2010-11-12 2016-05-19 Gentium S.R.L. Defibrotide for use in prophylaxis and/or treatment of Graft versus Host Disease (GVHD).
RU2627177C2 (ru) 2012-06-22 2017-08-03 Джентиум С.Р.Л. Способ определения биологической активности дефибротида, основанный на применении эуглобулина
EP3026122A1 (en) 2014-11-27 2016-06-01 Gentium S.p.A. Cellular-based method for determining the potency of defibrotide
CN111132663A (zh) 2017-08-03 2020-05-08 爵士制药爱尔兰有限公司 包含高浓度核酸的制剂
CN112236149A (zh) 2018-04-12 2021-01-15 贾兹制药公司 用于预防和治疗细胞因子释放综合征和与免疫耗竭相关的神经毒性的去纤苷
US20220023533A1 (en) 2018-12-07 2022-01-27 Jazz Phrmaceticals Ireland Limited Subcutaneous delivery of high concentration formulations
US20230190783A1 (en) 2020-02-28 2023-06-22 Jazz Pharmaceuticals Ireland Limited Delivery of low viscosity formulations
EP4135717A1 (en) 2020-04-17 2023-02-22 Jazz Pharmaceuticals Ireland Limited Defibrotide treatment for the prevention of organ rejection and injury
WO2022234101A1 (en) 2021-05-06 2022-11-10 Jazz Pharmaceuticals Ireland Limited Defibrotide for the treatment and prevention of acute respiratory distress syndrome

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US3829567A (en) * 1970-11-03 1974-08-13 Crinos Industria Farmaco Alkali metal salts of nucleotides useful as medicines for the fibronilityc system
US3899481A (en) * 1970-11-03 1975-08-12 Crinos Industria Farmaco Process for the controlled partial degradation of deoxyribonucleic acid extracted from animal organs
JP2001002565A (ja) * 1999-06-08 2001-01-09 Crinos Ind Farmacobiolog Spa カチオン性リポソームとポリデオキシリボヌクレオチドとの複合体
JP2004500437A (ja) * 2000-04-18 2004-01-08 ゲンチウム スパ 可動化活性を有する調製物
WO2006094917A2 (en) * 2005-03-03 2006-09-14 Gentium Spa Oligodeoxyribonucleotides of 4000-10000 dalton for treating tumors
WO2006119619A1 (en) * 2005-05-06 2006-11-16 Replicor Inc. Oligonucleotides inhibiting cell proliferation
JP2007504194A (ja) * 2003-09-05 2007-03-01 ゲンチウム エスピーエー デフィブロチド単独又は他の抗腫瘍剤との組み合わせを含む抗腫瘍製剤

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US3899481A (en) * 1970-11-03 1975-08-12 Crinos Industria Farmaco Process for the controlled partial degradation of deoxyribonucleic acid extracted from animal organs
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Also Published As

Publication number Publication date
AU2009226906B2 (en) 2015-05-07
IL207032A (en) 2016-08-31
KR20100124820A (ko) 2010-11-29
IL207032A0 (en) 2010-12-30
ES2647772T3 (es) 2017-12-26
WO2009115465A1 (en) 2009-09-24
EP2103689A1 (en) 2009-09-23
CN101978059A (zh) 2011-02-16
CA2712705C (en) 2017-08-15
CA2712705A1 (en) 2009-09-24
EP2252688A1 (en) 2010-11-24
US20110092576A1 (en) 2011-04-21
EP2252688B1 (en) 2017-08-16
DK2252688T3 (da) 2017-11-13
CN106361763A (zh) 2017-02-01
AU2009226906A1 (en) 2009-09-24

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