JP2011514314A5 - - Google Patents
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- Publication number
- JP2011514314A5 JP2011514314A5 JP2010544733A JP2010544733A JP2011514314A5 JP 2011514314 A5 JP2011514314 A5 JP 2011514314A5 JP 2010544733 A JP2010544733 A JP 2010544733A JP 2010544733 A JP2010544733 A JP 2010544733A JP 2011514314 A5 JP2011514314 A5 JP 2011514314A5
- Authority
- JP
- Japan
- Prior art keywords
- antibody
- derivative
- pain
- derivative according
- seq
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US2599508P | 2008-02-04 | 2008-02-04 | |
| US61/025,995 | 2008-02-04 | ||
| PCT/EP2009/051285 WO2009098238A1 (en) | 2008-02-04 | 2009-02-04 | Anti-trka antibodies and derivatives thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011514314A JP2011514314A (ja) | 2011-05-06 |
| JP2011514314A5 true JP2011514314A5 (https=) | 2012-03-15 |
| JP5719596B2 JP5719596B2 (ja) | 2015-05-20 |
Family
ID=40521960
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010544733A Expired - Fee Related JP5719596B2 (ja) | 2008-02-04 | 2009-02-04 | 抗体及びその誘導体 |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US9751947B2 (https=) |
| EP (1) | EP2252633B9 (https=) |
| JP (1) | JP5719596B2 (https=) |
| KR (1) | KR101782857B1 (https=) |
| CN (1) | CN101939337B (https=) |
| AP (1) | AP2929A (https=) |
| AU (1) | AU2009211340B2 (https=) |
| BR (1) | BRPI0905955A8 (https=) |
| CA (1) | CA2713786A1 (https=) |
| DK (1) | DK2252633T3 (https=) |
| EA (1) | EA021284B1 (https=) |
| ES (1) | ES2435917T3 (https=) |
| IL (1) | IL207390A (https=) |
| MX (1) | MX2010008571A (https=) |
| MY (1) | MY191348A (https=) |
| NZ (1) | NZ587701A (https=) |
| PL (1) | PL2252633T3 (https=) |
| PT (1) | PT2252633E (https=) |
| WO (1) | WO2009098238A1 (https=) |
| ZA (1) | ZA201006218B (https=) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1306704B1 (it) | 1999-05-26 | 2001-10-02 | Sirs Societa Italiana Per La R | Anticorpi monoclonali e suoi derivati sintetici o biotecnologici ingrado di agire come molecole antagoniste per il ngf. |
| ITRM20050290A1 (it) | 2005-06-07 | 2006-12-08 | Lay Line Genomics Spa | Uso di molecole in grado di inibire il legame tra ngf e il suo recettore trka come analgesici ad effetto prolungato. |
| ITRM20050332A1 (it) | 2005-06-24 | 2006-12-25 | Lay Line Genomics Spa | Uso di molecole in grado di bloccare l'attivita' di trka per potenziare gli effetti di analgesici oppiacei sul dolore. |
| US9751947B2 (en) | 2008-02-04 | 2017-09-05 | Lay Line Genomics S.P.A. | Antibodies and derivatives thereof |
| WO2010029497A1 (en) * | 2008-09-12 | 2010-03-18 | Pfizer Limited | Treatment of endometriosis |
| JP6190723B2 (ja) | 2010-12-01 | 2017-08-30 | アルダーバイオ ホールディングス エルエルシー | 抗ｎｇｆ組成物およびその使用 |
| US9884909B2 (en) | 2010-12-01 | 2018-02-06 | Alderbio Holdings Llc | Anti-NGF compositions and use thereof |
| US9539324B2 (en) | 2010-12-01 | 2017-01-10 | Alderbio Holdings, Llc | Methods of preventing inflammation and treating pain using anti-NGF compositions |
| US11214610B2 (en) | 2010-12-01 | 2022-01-04 | H. Lundbeck A/S | High-purity production of multi-subunit proteins such as antibodies in transformed microbes such as Pichia pastoris |
| US9067988B2 (en) | 2010-12-01 | 2015-06-30 | Alderbio Holdings Llc | Methods of preventing or treating pain using anti-NGF antibodies |
| US9078878B2 (en) | 2010-12-01 | 2015-07-14 | Alderbio Holdings Llc | Anti-NGF antibodies that selectively inhibit the association of NGF with TrkA, without affecting the association of NGF with p75 |
| US20150183885A1 (en) * | 2012-06-08 | 2015-07-02 | Glenmark Pharmaceuticals S.A. | Anti-trka antibodies with enhanced inhibitory properties and derivatives thereof |
| AP2014008145A0 (en) | 2012-06-08 | 2014-12-31 | Glenmark Pharmaceuticals Sa | Humanized anti-trkA antibodies with animo acid substitutions |
| EP2674439B1 (en) | 2012-06-13 | 2017-02-01 | Rottapharm Biotech S.r.l. | Anti-TrkA antibodies, derivatives and uses thereof |
| MA41097A (fr) * | 2014-12-05 | 2017-10-10 | Glenmark Pharmaceuticals Sa | Anticorps anti-trka à propriétés inhibitrices améliorées et dérivés desdits anticorps destinés à être utilisés pour traiter les douleurs osseuses |
| US10793634B2 (en) * | 2017-06-09 | 2020-10-06 | Boehringer Ingelheim International Gmbh | Anti-TrkB antibodies |
| AR114110A1 (es) | 2018-02-28 | 2020-07-22 | Lilly Co Eli | Anticuerpo anti-trka |
| CN109628425A (zh) * | 2019-01-02 | 2019-04-16 | 周越 | 一种人原肌球蛋白受体激酶a突变体及应用 |
| CN114230663B (zh) * | 2019-05-30 | 2022-09-27 | 广东东阳光药业有限公司 | TrkA的抗体及其应用 |
| WO2021092482A1 (en) * | 2019-11-06 | 2021-05-14 | The Regents Of The University Of California | Compositions and methods for transferrin receptor 1 targeting |
| US20230357411A1 (en) * | 2020-11-20 | 2023-11-09 | Sunshine Lake Pharma Co., Ltd. | Humanized anti-trka antibodies and uses thereof |
| CN112961244B (zh) | 2021-02-28 | 2023-08-29 | 熙源安健医药（上海）有限公司 | 抗TrkA抗体或其抗原结合片段、其制备方法和应用 |
| EP4457246A4 (en) * | 2021-12-28 | 2025-11-19 | 4B Tech Suzhou Limited | TRKA ANTIBODIES AND THEIR APPLICATION |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1988007089A1 (en) | 1987-03-18 | 1988-09-22 | Medical Research Council | Altered antibodies |
| US5530101A (en) * | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| US6491916B1 (en) | 1994-06-01 | 2002-12-10 | Tolerance Therapeutics, Inc. | Methods and materials for modulation of the immunosuppresive activity and toxicity of monoclonal antibodies |
| GB9525180D0 (en) | 1995-12-08 | 1996-02-07 | Univ Mcgill | Design of hormone-like antibodies with agonistic and antagonistic fuctions |
| EP0973898A2 (en) | 1997-04-10 | 2000-01-26 | Genetics Institute, Inc. | SECRETED EXPRESSED SEQUENCE TAGS (sESTs) |
| US6194551B1 (en) | 1998-04-02 | 2001-02-27 | Genentech, Inc. | Polypeptide variants |
| GB2340334B (en) * | 1998-07-29 | 2003-06-25 | Ericsson Telefon Ab L M | Telephone apparatus |
| IT1306704B1 (it) * | 1999-05-26 | 2001-10-02 | Sirs Societa Italiana Per La R | Anticorpi monoclonali e suoi derivati sintetici o biotecnologici ingrado di agire come molecole antagoniste per il ngf. |
| FR2807660A1 (fr) | 2000-04-13 | 2001-10-19 | Warner Lambert Co | Utilisation d'antagonistes du ngf pour la prevention ou le traitement de douleurs viscerales chroniques |
| ZA200502612B (en) | 2002-10-08 | 2007-07-25 | Rinat Neuroscience Corp | Methods for treating post-surgical pain by administering a nerve crowth factor antagonist and compositions containing the same |
| UA80447C2 (en) | 2002-10-08 | 2007-09-25 | Methods for treating pain by administering nerve growth factor antagonist and opioid analgesic | |
| US7255860B2 (en) | 2002-10-08 | 2007-08-14 | Rinat Neuroscience Corp. | Methods for treating post-surgical pain by administering an anti-nerve growth factor antagonist antibody |
| ITRM20030601A1 (it) * | 2003-12-24 | 2005-06-25 | Lay Line Genomics Spa | Metodo per l'umanizzazione di anticorpi e anticorpi umanizzati con esso ottenuti. |
| JP5301152B2 (ja) | 2004-04-07 | 2013-09-25 | ライナット ニューロサイエンス コーポレイション | 神経成長因子アンタゴニストを投与することによって骨癌の疼痛を処置するための方法 |
| ITRM20050290A1 (it) * | 2005-06-07 | 2006-12-08 | Lay Line Genomics Spa | Uso di molecole in grado di inibire il legame tra ngf e il suo recettore trka come analgesici ad effetto prolungato. |
| ITRM20050332A1 (it) * | 2005-06-24 | 2006-12-25 | Lay Line Genomics Spa | Uso di molecole in grado di bloccare l'attivita' di trka per potenziare gli effetti di analgesici oppiacei sul dolore. |
| US9751947B2 (en) | 2008-02-04 | 2017-09-05 | Lay Line Genomics S.P.A. | Antibodies and derivatives thereof |
| US8460657B2 (en) | 2008-06-25 | 2013-06-11 | H. Lundbeck A/S | Modulation of the TrpV: Vps10p receptor system for the treatment of pain |
-
2009
- 2009-02-04 US US12/866,184 patent/US9751947B2/en not_active Expired - Fee Related
- 2009-02-04 MX MX2010008571A patent/MX2010008571A/es active IP Right Grant
- 2009-02-04 PL PL09708019T patent/PL2252633T3/pl unknown
- 2009-02-04 DK DK09708019.6T patent/DK2252633T3/da active
- 2009-02-04 AU AU2009211340A patent/AU2009211340B2/en not_active Ceased
- 2009-02-04 PT PT97080196T patent/PT2252633E/pt unknown
- 2009-02-04 JP JP2010544733A patent/JP5719596B2/ja not_active Expired - Fee Related
- 2009-02-04 WO PCT/EP2009/051285 patent/WO2009098238A1/en not_active Ceased
- 2009-02-04 MY MYPI2010003574A patent/MY191348A/en unknown
- 2009-02-04 EP EP09708019.6A patent/EP2252633B9/en active Active
- 2009-02-04 ES ES09708019T patent/ES2435917T3/es active Active
- 2009-02-04 EA EA201070888A patent/EA021284B1/ru unknown
- 2009-02-04 CN CN200980104123.7A patent/CN101939337B/zh not_active Expired - Fee Related
- 2009-02-04 AP AP2010005379A patent/AP2929A/xx active
- 2009-02-04 BR BRPI0905955A patent/BRPI0905955A8/pt not_active Application Discontinuation
- 2009-02-04 NZ NZ587701A patent/NZ587701A/xx not_active IP Right Cessation
- 2009-02-04 KR KR1020107019748A patent/KR101782857B1/ko not_active Expired - Fee Related
- 2009-02-04 CA CA2713786A patent/CA2713786A1/en not_active Abandoned
-
2010
- 2010-08-03 IL IL207390A patent/IL207390A/en active IP Right Grant
- 2010-08-31 ZA ZA2010/06218A patent/ZA201006218B/en unknown
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