JP2011514314A5 - - Google Patents
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- Publication number
- JP2011514314A5 JP2011514314A5 JP2010544733A JP2010544733A JP2011514314A5 JP 2011514314 A5 JP2011514314 A5 JP 2011514314A5 JP 2010544733 A JP2010544733 A JP 2010544733A JP 2010544733 A JP2010544733 A JP 2010544733A JP 2011514314 A5 JP2011514314 A5 JP 2011514314A5
- Authority
- JP
- Japan
- Prior art keywords
- antibody
- derivative
- pain
- derivative according
- seq
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US2599508P | 2008-02-04 | 2008-02-04 | |
| US61/025,995 | 2008-02-04 | ||
| PCT/EP2009/051285 WO2009098238A1 (en) | 2008-02-04 | 2009-02-04 | Anti-trka antibodies and derivatives thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011514314A JP2011514314A (ja) | 2011-05-06 |
| JP2011514314A5 true JP2011514314A5 (https=) | 2012-03-15 |
| JP5719596B2 JP5719596B2 (ja) | 2015-05-20 |
Family
ID=40521960
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010544733A Expired - Fee Related JP5719596B2 (ja) | 2008-02-04 | 2009-02-04 | 抗体及びその誘導体 |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US9751947B2 (https=) |
| EP (1) | EP2252633B9 (https=) |
| JP (1) | JP5719596B2 (https=) |
| KR (1) | KR101782857B1 (https=) |
| CN (1) | CN101939337B (https=) |
| AP (1) | AP2929A (https=) |
| AU (1) | AU2009211340B2 (https=) |
| BR (1) | BRPI0905955A8 (https=) |
| CA (1) | CA2713786A1 (https=) |
| DK (1) | DK2252633T3 (https=) |
| EA (1) | EA021284B1 (https=) |
| ES (1) | ES2435917T3 (https=) |
| IL (1) | IL207390A (https=) |
| MX (1) | MX2010008571A (https=) |
| MY (1) | MY191348A (https=) |
| NZ (1) | NZ587701A (https=) |
| PL (1) | PL2252633T3 (https=) |
| PT (1) | PT2252633E (https=) |
| WO (1) | WO2009098238A1 (https=) |
| ZA (1) | ZA201006218B (https=) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1306704B1 (it) | 1999-05-26 | 2001-10-02 | Sirs Societa Italiana Per La R | Anticorpi monoclonali e suoi derivati sintetici o biotecnologici ingrado di agire come molecole antagoniste per il ngf. |
| ITRM20050290A1 (it) | 2005-06-07 | 2006-12-08 | Lay Line Genomics Spa | Uso di molecole in grado di inibire il legame tra ngf e il suo recettore trka come analgesici ad effetto prolungato. |
| ITRM20050332A1 (it) | 2005-06-24 | 2006-12-25 | Lay Line Genomics Spa | Uso di molecole in grado di bloccare l'attivita' di trka per potenziare gli effetti di analgesici oppiacei sul dolore. |
| EP2252633B9 (en) | 2008-02-04 | 2014-02-19 | Lay Line Genomics S.P.A. | Anti-trka antibodies and derivatives thereof |
| WO2010029497A1 (en) * | 2008-09-12 | 2010-03-18 | Pfizer Limited | Treatment of endometriosis |
| US9539324B2 (en) | 2010-12-01 | 2017-01-10 | Alderbio Holdings, Llc | Methods of preventing inflammation and treating pain using anti-NGF compositions |
| US11214610B2 (en) | 2010-12-01 | 2022-01-04 | H. Lundbeck A/S | High-purity production of multi-subunit proteins such as antibodies in transformed microbes such as Pichia pastoris |
| US9078878B2 (en) | 2010-12-01 | 2015-07-14 | Alderbio Holdings Llc | Anti-NGF antibodies that selectively inhibit the association of NGF with TrkA, without affecting the association of NGF with p75 |
| EP2646468B1 (en) | 2010-12-01 | 2018-07-25 | AlderBio Holdings LLC | Anti-ngf compositions and use thereof |
| US9884909B2 (en) | 2010-12-01 | 2018-02-06 | Alderbio Holdings Llc | Anti-NGF compositions and use thereof |
| US9067988B2 (en) | 2010-12-01 | 2015-06-30 | Alderbio Holdings Llc | Methods of preventing or treating pain using anti-NGF antibodies |
| US20150183885A1 (en) * | 2012-06-08 | 2015-07-02 | Glenmark Pharmaceuticals S.A. | Anti-trka antibodies with enhanced inhibitory properties and derivatives thereof |
| ES2666126T3 (es) * | 2012-06-08 | 2018-05-03 | Glenmark Pharmaceuticals S.A. | Anticuerpos anti-TrkA humanizados con sustituciones de aminoácidos |
| EP2674439B1 (en) | 2012-06-13 | 2017-02-01 | Rottapharm Biotech S.r.l. | Anti-TrkA antibodies, derivatives and uses thereof |
| MA41097A (fr) * | 2014-12-05 | 2017-10-10 | Glenmark Pharmaceuticals Sa | Anticorps anti-trka à propriétés inhibitrices améliorées et dérivés desdits anticorps destinés à être utilisés pour traiter les douleurs osseuses |
| US10793634B2 (en) * | 2017-06-09 | 2020-10-06 | Boehringer Ingelheim International Gmbh | Anti-TrkB antibodies |
| AR114110A1 (es) | 2018-02-28 | 2020-07-22 | Lilly Co Eli | Anticuerpo anti-trka |
| CN109628425A (zh) * | 2019-01-02 | 2019-04-16 | 周越 | 一种人原肌球蛋白受体激酶a突变体及应用 |
| EP3976657A4 (en) * | 2019-05-30 | 2023-07-05 | Sunshine Lake Pharma Co., Ltd. | ANTI-TRKA ANTIBODIES AND USES THEREOF |
| EP4069745A4 (en) * | 2019-11-06 | 2024-05-29 | The Regents Of The University Of California | COMPOSITIONS AND METHODS FOR TRANSFERRIN RECEPTOR 1 TARGETING |
| JP7837873B2 (ja) * | 2020-11-20 | 2026-03-31 | サンシャイン・レイク・ファーマ・カンパニー・リミテッド | ヒト化抗ＴｒｋＡ抗体及びその使用 |
| CN112961244B (zh) * | 2021-02-28 | 2023-08-29 | 熙源安健医药（上海）有限公司 | 抗TrkA抗体或其抗原结合片段、其制备方法和应用 |
| JP2025503539A (ja) | 2021-12-28 | 2025-02-04 | ４ビー テクノロジーズ（スーヂョウ） リミテッド | ＴｒｋＡ抗体とその応用 |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3101690B2 (ja) * | 1987-03-18 | 2000-10-23 | エス・ビィ・２・インコーポレイテッド | 変性抗体の、または変性抗体に関する改良 |
| US5530101A (en) * | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| US6491916B1 (en) * | 1994-06-01 | 2002-12-10 | Tolerance Therapeutics, Inc. | Methods and materials for modulation of the immunosuppresive activity and toxicity of monoclonal antibodies |
| GB9525180D0 (en) | 1995-12-08 | 1996-02-07 | Univ Mcgill | Design of hormone-like antibodies with agonistic and antagonistic fuctions |
| JP2001519666A (ja) | 1997-04-10 | 2001-10-23 | ジェネティックス・インスチチュート・インコーポレーテッド | 分泌発現配列タグ（ｓＥＳＴｓ） |
| US6194551B1 (en) * | 1998-04-02 | 2001-02-27 | Genentech, Inc. | Polypeptide variants |
| GB2340334B (en) * | 1998-07-29 | 2003-06-25 | Ericsson Telefon Ab L M | Telephone apparatus |
| IT1306704B1 (it) * | 1999-05-26 | 2001-10-02 | Sirs Societa Italiana Per La R | Anticorpi monoclonali e suoi derivati sintetici o biotecnologici ingrado di agire come molecole antagoniste per il ngf. |
| FR2807660A1 (fr) | 2000-04-13 | 2001-10-19 | Warner Lambert Co | Utilisation d'antagonistes du ngf pour la prevention ou le traitement de douleurs viscerales chroniques |
| WO2005000194A2 (en) | 2002-10-08 | 2005-01-06 | Rinat Neuroscience Corp. | Methods for treating post-surgical pain by administering an anti-nerve growth factor antagonist antibody and compositions containing the same |
| UA80447C2 (en) | 2002-10-08 | 2007-09-25 | Methods for treating pain by administering nerve growth factor antagonist and opioid analgesic | |
| ZA200502612B (en) | 2002-10-08 | 2007-07-25 | Rinat Neuroscience Corp | Methods for treating post-surgical pain by administering a nerve crowth factor antagonist and compositions containing the same |
| ITRM20030601A1 (it) * | 2003-12-24 | 2005-06-25 | Lay Line Genomics Spa | Metodo per l'umanizzazione di anticorpi e anticorpi umanizzati con esso ottenuti. |
| EP3372614B1 (en) | 2004-04-07 | 2022-06-08 | Rinat Neuroscience Corp. | Methods for treating bone cancer pain by administering a nerve growth factor antagonist |
| ITRM20050290A1 (it) * | 2005-06-07 | 2006-12-08 | Lay Line Genomics Spa | Uso di molecole in grado di inibire il legame tra ngf e il suo recettore trka come analgesici ad effetto prolungato. |
| ITRM20050332A1 (it) * | 2005-06-24 | 2006-12-25 | Lay Line Genomics Spa | Uso di molecole in grado di bloccare l'attivita' di trka per potenziare gli effetti di analgesici oppiacei sul dolore. |
| EP2252633B9 (en) | 2008-02-04 | 2014-02-19 | Lay Line Genomics S.P.A. | Anti-trka antibodies and derivatives thereof |
| EP2307042B1 (en) | 2008-06-25 | 2014-03-26 | H. Lundbeck A/S | Modulation of the trpv : vps10p-domain receptor system for the treatment of pain |
-
2009
- 2009-02-04 EP EP09708019.6A patent/EP2252633B9/en active Active
- 2009-02-04 PT PT97080196T patent/PT2252633E/pt unknown
- 2009-02-04 NZ NZ587701A patent/NZ587701A/xx not_active IP Right Cessation
- 2009-02-04 ES ES09708019T patent/ES2435917T3/es active Active
- 2009-02-04 JP JP2010544733A patent/JP5719596B2/ja not_active Expired - Fee Related
- 2009-02-04 EA EA201070888A patent/EA021284B1/ru unknown
- 2009-02-04 AP AP2010005379A patent/AP2929A/xx active
- 2009-02-04 MY MYPI2010003574A patent/MY191348A/en unknown
- 2009-02-04 MX MX2010008571A patent/MX2010008571A/es active IP Right Grant
- 2009-02-04 AU AU2009211340A patent/AU2009211340B2/en not_active Ceased
- 2009-02-04 CA CA2713786A patent/CA2713786A1/en not_active Abandoned
- 2009-02-04 KR KR1020107019748A patent/KR101782857B1/ko not_active Expired - Fee Related
- 2009-02-04 PL PL09708019T patent/PL2252633T3/pl unknown
- 2009-02-04 BR BRPI0905955A patent/BRPI0905955A8/pt not_active Application Discontinuation
- 2009-02-04 WO PCT/EP2009/051285 patent/WO2009098238A1/en not_active Ceased
- 2009-02-04 US US12/866,184 patent/US9751947B2/en not_active Expired - Fee Related
- 2009-02-04 DK DK09708019.6T patent/DK2252633T3/da active
- 2009-02-04 CN CN200980104123.7A patent/CN101939337B/zh not_active Expired - Fee Related
-
2010
- 2010-08-03 IL IL207390A patent/IL207390A/en active IP Right Grant
- 2010-08-31 ZA ZA2010/06218A patent/ZA201006218B/en unknown
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