JP2011513196A - ドーパミン作動系が破壊された障害もしくは状態の症状を軽減するためまたはその障害もしくは状態を処置するためのｋｃｎｑカリウムチャネル開口薬の使用 - Google Patents

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Publication number

JP2011513196A

JP2011513196A JP2010518498A JP2010518498A JP2011513196A JP 2011513196 A JP2011513196 A JP 2011513196A JP 2010518498 A JP2010518498 A JP 2010518498A JP 2010518498 A JP2010518498 A JP 2010518498A JP 2011513196 A JP2011513196 A JP 2011513196A

Authority

JP

Japan

Prior art keywords

phenyl

keni

amino

methyl

alk

Prior art date

2007-08-01

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Ceased

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• 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims description 8
• QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims description 8
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• HBAVDOFSYDZLMI-UHFFFAOYSA-N 2-amino-4-methyl-n-[2-methyl-4-[[4-(trifluoromethyl)phenyl]methylamino]phenyl]pentanamide Chemical compound C1=C(C)C(NC(=O)C(N)CC(C)C)=CC=C1NCC1=CC=C(C(F)(F)F)C=C1 HBAVDOFSYDZLMI-UHFFFAOYSA-N 0.000 claims description 4
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• PIQCXJAFLBNPHH-UHFFFAOYSA-N (4-nitrophenyl)methyl n-[2-chloro-4-[(5-chlorothiophen-2-yl)methyl-methylamino]phenyl]carbamate Chemical compound C=1C=C(NC(=O)OCC=2C=CC(=CC=2)[N+]([O-])=O)C(Cl)=CC=1N(C)CC1=CC=C(Cl)S1 PIQCXJAFLBNPHH-UHFFFAOYSA-N 0.000 claims description 2
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• YOJFQPSCGOKXON-UHFFFAOYSA-N 1-[1-[(5-chlorothiophen-2-yl)methyl]-2,3-dihydroindol-5-yl]-3-thiophen-3-ylurea Chemical compound S1C(Cl)=CC=C1CN1C2=CC=C(NC(=O)NC3=CSC=C3)C=C2CC1 YOJFQPSCGOKXON-UHFFFAOYSA-N 0.000 claims description 2
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• XXORMBACYMRYFK-UHFFFAOYSA-N 1-[2-cyclopentyloxy-4-[(4-fluorophenyl)methyl-methylamino]phenyl]-3-ethylurea Chemical compound CCNC(=O)NC1=CC=C(N(C)CC=2C=CC(F)=CC=2)C=C1OC1CCCC1 XXORMBACYMRYFK-UHFFFAOYSA-N 0.000 claims description 2
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• GLHVEYVVFXLYTL-UHFFFAOYSA-N 2,2-dimethyl-n-[2-methyl-4-[(6-phenoxypyridin-3-yl)methylamino]phenyl]propanamide Chemical compound C1=C(NC(=O)C(C)(C)C)C(C)=CC(NCC=2C=NC(OC=3C=CC=CC=3)=CC=2)=C1 GLHVEYVVFXLYTL-UHFFFAOYSA-N 0.000 claims description 2
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• MYGXIGJESMGAQN-UHFFFAOYSA-N 2,2-dimethylpropyl n-[2-chloro-4-[(5-chlorothiophen-2-yl)methyl-methylamino]phenyl]carbamate Chemical compound C=1C=C(NC(=O)OCC(C)(C)C)C(Cl)=CC=1N(C)CC1=CC=C(Cl)S1 MYGXIGJESMGAQN-UHFFFAOYSA-N 0.000 claims description 2
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• CSEQTDRDZQLHLC-UHFFFAOYSA-N 2-(4-fluorophenyl)-n-[6-nitro-1-[[4-(trifluoromethyl)phenyl]methyl]-2,3-dihydroindol-5-yl]acetamide Chemical compound C1CC=2C=C(NC(=O)CC=3C=CC(F)=CC=3)C([N+](=O)[O-])=CC=2N1CC1=CC=C(C(F)(F)F)C=C1 CSEQTDRDZQLHLC-UHFFFAOYSA-N 0.000 claims description 2
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• LTINJHGWWBUWHC-UHFFFAOYSA-N 2-cyclopent-2-en-1-yl-n-[2-methyl-4-morpholin-4-yl-6-(trifluoromethyl)phenyl]acetamide Chemical compound CC1=CC(N2CCOCC2)=CC(C(F)(F)F)=C1NC(=O)CC1CCC=C1 LTINJHGWWBUWHC-UHFFFAOYSA-N 0.000 claims description 2
• ZWODLPCPFZMMPF-UHFFFAOYSA-N 2-cyclopentyl-n-(2,4-dimethyl-6-morpholin-4-ylpyridin-3-yl)acetamide Chemical compound CC1=CC(N2CCOCC2)=NC(C)=C1NC(=O)CC1CCCC1 ZWODLPCPFZMMPF-UHFFFAOYSA-N 0.000 claims description 2
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• XBHFMQFTDNMLBJ-UHFFFAOYSA-N 2-cyclopentyl-n-(2,6-difluoro-4-morpholin-4-ylphenyl)acetamide Chemical compound FC1=CC(N2CCOCC2)=CC(F)=C1NC(=O)CC1CCCC1 XBHFMQFTDNMLBJ-UHFFFAOYSA-N 0.000 claims description 2
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• IKPVUBMYZIWNRW-UHFFFAOYSA-N 2-cyclopentyl-n-(2,6-dimethyl-4-thiomorpholin-4-ylphenyl)acetamide Chemical compound CC1=CC(N2CCSCC2)=CC(C)=C1NC(=O)CC1CCCC1 IKPVUBMYZIWNRW-UHFFFAOYSA-N 0.000 claims description 2
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• WAVXDFUOPQGUBX-UHFFFAOYSA-N 2-cyclopentyl-n-[2,6-dimethyl-4-(2-phenylthiomorpholin-4-yl)phenyl]acetamide Chemical compound CC1=CC(N2CC(SCC2)C=2C=CC=CC=2)=CC(C)=C1NC(=O)CC1CCCC1 WAVXDFUOPQGUBX-UHFFFAOYSA-N 0.000 claims description 2
• WNTSBBJWRJVJGJ-UHFFFAOYSA-N 2-cyclopentyl-n-[2,6-dimethyl-4-(3-pyridin-3-ylthiomorpholin-4-yl)phenyl]acetamide Chemical compound CC1=CC(N2C(CSCC2)C=2C=NC=CC=2)=CC(C)=C1NC(=O)CC1CCCC1 WNTSBBJWRJVJGJ-UHFFFAOYSA-N 0.000 claims description 2
• WRDIBHFRJFDWAW-UHFFFAOYSA-N 2-cyclopentyl-n-[2,6-dimethyl-4-[(4-methylanilino)methyl]phenyl]acetamide Chemical compound C1=CC(C)=CC=C1NCC(C=C1C)=CC(C)=C1NC(=O)CC1CCCC1 WRDIBHFRJFDWAW-UHFFFAOYSA-N 0.000 claims description 2
• OYVKDFWBJVLPQJ-UHFFFAOYSA-N 2-cyclopentyl-n-[2,6-dimethyl-4-[2-[4-(trifluoromethyl)phenyl]morpholin-4-yl]phenyl]acetamide Chemical compound CC1=CC(N2CC(OCC2)C=2C=CC(=CC=2)C(F)(F)F)=CC(C)=C1NC(=O)CC1CCCC1 OYVKDFWBJVLPQJ-UHFFFAOYSA-N 0.000 claims description 2
• PMAATXNYIJEXNJ-UHFFFAOYSA-N 2-cyclopentyl-n-[2,6-dimethyl-4-[2-[4-(trifluoromethyl)phenyl]pyrrolidin-1-yl]phenyl]acetamide Chemical compound CC1=CC(N2C(CCC2)C=2C=CC(=CC=2)C(F)(F)F)=CC(C)=C1NC(=O)CC1CCCC1 PMAATXNYIJEXNJ-UHFFFAOYSA-N 0.000 claims description 2
• FKTVZYJYGPVDFU-UHFFFAOYSA-N 2-cyclopentyl-n-[2,6-dimethyl-4-[2-[4-(trifluoromethyl)phenyl]thiomorpholin-4-yl]phenyl]acetamide Chemical compound CC1=CC(N2CC(SCC2)C=2C=CC(=CC=2)C(F)(F)F)=CC(C)=C1NC(=O)CC1CCCC1 FKTVZYJYGPVDFU-UHFFFAOYSA-N 0.000 claims description 2
• BHVKYMSGYOOSCM-UHFFFAOYSA-N 2-cyclopentyl-n-[2,6-dimethyl-4-[[3-(trifluoromethyl)anilino]methyl]phenyl]acetamide Chemical compound C=1C(C)=C(NC(=O)CC2CCCC2)C(C)=CC=1CNC1=CC=CC(C(F)(F)F)=C1 BHVKYMSGYOOSCM-UHFFFAOYSA-N 0.000 claims description 2
• CUDFPNFQWMAENQ-UHFFFAOYSA-N 2-cyclopentyl-n-[2,6-dimethyl-4-[[4-(trifluoromethyl)anilino]methyl]phenyl]acetamide Chemical compound C=1C(C)=C(NC(=O)CC2CCCC2)C(C)=CC=1CNC1=CC=C(C(F)(F)F)C=C1 CUDFPNFQWMAENQ-UHFFFAOYSA-N 0.000 claims description 2
• RSXOPFCHOGTEKQ-UHFFFAOYSA-N 2-cyclopentyl-n-[2,6-dimethyl-4-[[4-(trifluoromethyl)phenyl]methylamino]phenyl]acetamide Chemical compound C=1C(C)=C(NC(=O)CC2CCCC2)C(C)=CC=1NCC1=CC=C(C(F)(F)F)C=C1 RSXOPFCHOGTEKQ-UHFFFAOYSA-N 0.000 claims description 2
• DLDVNHYJIZFLMR-UHFFFAOYSA-N 2-cyclopentyl-n-[2,6-dimethyl-4-[[6-(trifluoromethyl)pyridin-3-yl]methylamino]phenyl]acetamide Chemical compound C=1C(C)=C(NC(=O)CC2CCCC2)C(C)=CC=1NCC1=CC=C(C(F)(F)F)N=C1 DLDVNHYJIZFLMR-UHFFFAOYSA-N 0.000 claims description 2
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• VVYOXVXPNLGNFB-UHFFFAOYSA-N 3-[1-[(5-chlorothiophen-2-yl)methyl]-2,3-dihydroindol-5-yl]-1-methyl-1-propylurea Chemical compound C1CC2=CC(NC(=O)N(C)CCC)=CC=C2N1CC1=CC=C(Cl)S1 VVYOXVXPNLGNFB-UHFFFAOYSA-N 0.000 claims description 2
• SJAIYFDQCITQLJ-UHFFFAOYSA-N 3-[2-chloro-4-[(5-chlorothiophen-2-yl)methyl-methylamino]phenyl]-1-methyl-1-propylurea Chemical compound C1=C(Cl)C(NC(=O)N(C)CCC)=CC=C1N(C)CC1=CC=C(Cl)S1 SJAIYFDQCITQLJ-UHFFFAOYSA-N 0.000 claims description 2
• NKRSJPBJRWPWTO-UHFFFAOYSA-N 3-chloropropyl n-[2-chloro-4-[(5-chlorothiophen-2-yl)methyl-methylamino]phenyl]carbamate Chemical compound C=1C=C(NC(=O)OCCCCl)C(Cl)=CC=1N(C)CC1=CC=C(Cl)S1 NKRSJPBJRWPWTO-UHFFFAOYSA-N 0.000 claims description 2
• PVKGAFIBJUZLPW-UHFFFAOYSA-N 3-cyclohexyl-n-(2,4-dimethyl-6-morpholin-4-ylpyridin-3-yl)propanamide Chemical compound CC1=CC(N2CCOCC2)=NC(C)=C1NC(=O)CCC1CCCCC1 PVKGAFIBJUZLPW-UHFFFAOYSA-N 0.000 claims description 2
• FFJSHGKHOFZMRC-UHFFFAOYSA-N 3-cyclohexyl-n-(2,6-dimethyl-4-morpholin-4-ylphenyl)propanamide Chemical compound CC1=CC(N2CCOCC2)=CC(C)=C1NC(=O)CCC1CCCCC1 FFJSHGKHOFZMRC-UHFFFAOYSA-N 0.000 claims description 2
• WHTGDXHISJRNKN-UHFFFAOYSA-N 3-cyclopentyl-n-(2,4-dimethyl-6-morpholin-4-ylpyridin-3-yl)propanamide Chemical compound CC1=CC(N2CCOCC2)=NC(C)=C1NC(=O)CCC1CCCC1 WHTGDXHISJRNKN-UHFFFAOYSA-N 0.000 claims description 2
• FQHLBMKMJMGTSG-UHFFFAOYSA-N 3-cyclopentyl-n-(2,6-dimethyl-4-morpholin-4-ylphenyl)propanamide Chemical compound CC1=CC(N2CCOCC2)=CC(C)=C1NC(=O)CCC1CCCC1 FQHLBMKMJMGTSG-UHFFFAOYSA-N 0.000 claims description 2
• LZNUPNICZDUTMX-UHFFFAOYSA-N 4-fluoro-n-[1-[(4-fluorophenyl)methyl]-2,3-dihydroindol-5-yl]benzamide Chemical compound C1=CC(F)=CC=C1CN1C2=CC=C(NC(=O)C=3C=CC(F)=CC=3)C=C2CC1 LZNUPNICZDUTMX-UHFFFAOYSA-N 0.000 claims description 2
• 125000001318 4-trifluoromethylbenzyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1C([H])([H])*)C(F)(F)F 0.000 claims description 2
• OGABBSFCFIJRPK-UHFFFAOYSA-N 5-methyl-n-[2-methyl-4-morpholin-4-yl-6-(trifluoromethyl)phenyl]hexanamide Chemical compound C1=C(C(F)(F)F)C(NC(=O)CCCC(C)C)=C(C)C=C1N1CCOCC1 OGABBSFCFIJRPK-UHFFFAOYSA-N 0.000 claims description 2
• IAUIUXXKRXWWNW-UHFFFAOYSA-N COC1=CSC2=C1C=CC(=C2)Cl Chemical compound COC1=CSC2=C1C=CC(=C2)Cl IAUIUXXKRXWWNW-UHFFFAOYSA-N 0.000 claims description 2
• WWZKQHOCKIZLMA-UHFFFAOYSA-N Caprylic acid Natural products CCCCCCCC(O)=O WWZKQHOCKIZLMA-UHFFFAOYSA-N 0.000 claims description 2
• 208000026139 Memory disease Diseases 0.000 claims description 2
• 208000013716 Motor tics Diseases 0.000 claims description 2
• 235000018936 Vitellaria paradoxa Nutrition 0.000 claims description 2
• 125000005161 aryl oxy carbonyl group Chemical group 0.000 claims description 2
• KAEMILXLUFFLSU-UHFFFAOYSA-N benzyl n-(2,4-dimethyl-6-morpholin-4-ylpyridin-3-yl)carbamate Chemical compound CC1=CC(N2CCOCC2)=NC(C)=C1NC(=O)OCC1=CC=CC=C1 KAEMILXLUFFLSU-UHFFFAOYSA-N 0.000 claims description 2
• DDAWRADOFRFSCU-UHFFFAOYSA-N benzyl n-(2,6-dimethyl-4-morpholin-4-ylphenyl)carbamate Chemical compound CC1=CC(N2CCOCC2)=CC(C)=C1NC(=O)OCC1=CC=CC=C1 DDAWRADOFRFSCU-UHFFFAOYSA-N 0.000 claims description 2
• QIUJJJVRYWFJPB-UHFFFAOYSA-N benzyl n-[2-chloro-4-[(5-chlorothiophen-2-yl)methyl-methylamino]phenyl]carbamate Chemical compound C=1C=C(NC(=O)OCC=2C=CC=CC=2)C(Cl)=CC=1N(C)CC1=CC=C(Cl)S1 QIUJJJVRYWFJPB-UHFFFAOYSA-N 0.000 claims description 2
• GONOPSZTUGRENK-UHFFFAOYSA-N benzyl(trichloro)silane Chemical compound Cl[Si](Cl)(Cl)CC1=CC=CC=C1 GONOPSZTUGRENK-UHFFFAOYSA-N 0.000 claims description 2
• GFLUXUNNWRGAJS-UHFFFAOYSA-N but-2-ynyl n-[2-chloro-4-[(5-chlorothiophen-2-yl)methyl-methylamino]phenyl]carbamate Chemical compound C1=C(Cl)C(NC(=O)OCC#CC)=CC=C1N(C)CC1=CC=C(Cl)S1 GFLUXUNNWRGAJS-UHFFFAOYSA-N 0.000 claims description 2
• NTCMMLFINXWYDI-UHFFFAOYSA-N but-3-enyl n-[2-chloro-4-[(5-chlorothiophen-2-yl)methyl-methylamino]phenyl]carbamate Chemical compound C=1C=C(NC(=O)OCCC=C)C(Cl)=CC=1N(C)CC1=CC=C(Cl)S1 NTCMMLFINXWYDI-UHFFFAOYSA-N 0.000 claims description 2
• CSWQFUWZYDMBLR-UHFFFAOYSA-N butyl n-(2,6-dimethyl-4-morpholin-4-ylphenyl)carbamate Chemical compound C1=C(C)C(NC(=O)OCCCC)=C(C)C=C1N1CCOCC1 CSWQFUWZYDMBLR-UHFFFAOYSA-N 0.000 claims description 2
• RRBPKGFPYVBTPQ-UHFFFAOYSA-N butyl n-[2-chloro-4-[(5-chlorothiophen-2-yl)methyl-methylamino]phenyl]carbamate Chemical compound C1=C(Cl)C(NC(=O)OCCCC)=CC=C1N(C)CC1=CC=C(Cl)S1 RRBPKGFPYVBTPQ-UHFFFAOYSA-N 0.000 claims description 2
• 230000003001 depressive effect Effects 0.000 claims description 2
• YYIFYTOIDVFSJM-UHFFFAOYSA-N ethyl n-(4-bromo-2,6-dimethylphenyl)carbamate Chemical compound CCOC(=O)NC1=C(C)C=C(Br)C=C1C YYIFYTOIDVFSJM-UHFFFAOYSA-N 0.000 claims description 2
• IECMFWSPQDIVPW-UHFFFAOYSA-N ethyl n-[2,6-dimethyl-4-[[4-(trifluoromethyl)anilino]methyl]phenyl]carbamate Chemical compound C1=C(C)C(NC(=O)OCC)=C(C)C=C1CNC1=CC=C(C(F)(F)F)C=C1 IECMFWSPQDIVPW-UHFFFAOYSA-N 0.000 claims description 2
• LVDKVOBNMQQEAL-UHFFFAOYSA-N ethyl n-[2-(4-chlorophenyl)-4-[(3-fluoroanilino)methyl]phenyl]carbamate Chemical compound C1=C(C=2C=CC(Cl)=CC=2)C(NC(=O)OCC)=CC=C1CNC1=CC=CC(F)=C1 LVDKVOBNMQQEAL-UHFFFAOYSA-N 0.000 claims description 2
• JBASQAITBFAGGZ-UHFFFAOYSA-N ethyl n-[2-(4-chlorophenyl)-4-[[4-(trifluoromethyl)anilino]methyl]phenyl]carbamate Chemical compound C1=C(C=2C=CC(Cl)=CC=2)C(NC(=O)OCC)=CC=C1CNC1=CC=C(C(F)(F)F)C=C1 JBASQAITBFAGGZ-UHFFFAOYSA-N 0.000 claims description 2
• AVLRKXVHQCYJLZ-UHFFFAOYSA-N ethyl n-[2-[4-(dimethylamino)phenyl]-4-[(3-fluoroanilino)methyl]phenyl]carbamate Chemical compound C1=C(C=2C=CC(=CC=2)N(C)C)C(NC(=O)OCC)=CC=C1CNC1=CC=CC(F)=C1 AVLRKXVHQCYJLZ-UHFFFAOYSA-N 0.000 claims description 2
• TYFOODIYYYOWKK-UHFFFAOYSA-N ethyl n-[2-[4-(dimethylamino)phenyl]-4-[[4-(trifluoromethyl)anilino]methyl]phenyl]carbamate Chemical compound C1=C(C=2C=CC(=CC=2)N(C)C)C(NC(=O)OCC)=CC=C1CNC1=CC=C(C(F)(F)F)C=C1 TYFOODIYYYOWKK-UHFFFAOYSA-N 0.000 claims description 2
• KXYHFTARJIQOMA-UHFFFAOYSA-N ethyl n-[2-amino-4-(1-benzothiophen-3-ylmethylamino)phenyl]carbamate Chemical compound C1=C(N)C(NC(=O)OCC)=CC=C1NCC1=CSC2=CC=CC=C12 KXYHFTARJIQOMA-UHFFFAOYSA-N 0.000 claims description 2
• PAUMPFSSOXRDEJ-UHFFFAOYSA-N ethyl n-[2-amino-4-(anilinomethyl)phenyl]carbamate Chemical compound C1=C(N)C(NC(=O)OCC)=CC=C1CNC1=CC=CC=C1 PAUMPFSSOXRDEJ-UHFFFAOYSA-N 0.000 claims description 2
• CYVMSJCKTMVSRR-UHFFFAOYSA-N ethyl n-[2-amino-4-(thiophen-2-ylmethylamino)phenyl]carbamate Chemical compound C1=C(N)C(NC(=O)OCC)=CC=C1NCC1=CC=CS1 CYVMSJCKTMVSRR-UHFFFAOYSA-N 0.000 claims description 2
• WALRLVHHRQJWMT-UHFFFAOYSA-N ethyl n-[2-amino-4-(thiophen-3-ylmethylamino)phenyl]carbamate Chemical compound C1=C(N)C(NC(=O)OCC)=CC=C1NCC1=CSC=C1 WALRLVHHRQJWMT-UHFFFAOYSA-N 0.000 claims description 2
• XFNGDUVFJSECBN-UHFFFAOYSA-N ethyl n-[2-amino-4-[(2,3-dichloroanilino)methyl]phenyl]carbamate Chemical compound C1=C(N)C(NC(=O)OCC)=CC=C1CNC1=CC=CC(Cl)=C1Cl XFNGDUVFJSECBN-UHFFFAOYSA-N 0.000 claims description 2
• NPFOVUKAFGUSQL-UHFFFAOYSA-N ethyl n-[2-amino-4-[(2,3-dihydro-1h-inden-5-ylamino)methyl]phenyl]carbamate Chemical compound C1=C(N)C(NC(=O)OCC)=CC=C1CNC1=CC=C(CCC2)C2=C1 NPFOVUKAFGUSQL-UHFFFAOYSA-N 0.000 claims description 2
• SCOOTUMXCXKEAD-UHFFFAOYSA-N ethyl n-[2-amino-4-[(2,4,6-trimethylphenyl)methylamino]phenyl]carbamate Chemical compound C1=C(N)C(NC(=O)OCC)=CC=C1NCC1=C(C)C=C(C)C=C1C SCOOTUMXCXKEAD-UHFFFAOYSA-N 0.000 claims description 2
• MPNLUKUAXMXGGU-UHFFFAOYSA-N ethyl n-[2-amino-4-[(2,4-dichloroanilino)methyl]phenyl]carbamate Chemical compound C1=C(N)C(NC(=O)OCC)=CC=C1CNC1=CC=C(Cl)C=C1Cl MPNLUKUAXMXGGU-UHFFFAOYSA-N 0.000 claims description 2
• XVKFYUITXXYYEN-UHFFFAOYSA-N ethyl n-[2-amino-4-[(2,4-difluoroanilino)methyl]phenyl]carbamate Chemical compound C1=C(N)C(NC(=O)OCC)=CC=C1CNC1=CC=C(F)C=C1F XVKFYUITXXYYEN-UHFFFAOYSA-N 0.000 claims description 2
• VDDRKSVFMCGVKS-UHFFFAOYSA-N ethyl n-[2-amino-4-[(2-fluoroanilino)methyl]phenyl]carbamate Chemical compound C1=C(N)C(NC(=O)OCC)=CC=C1CNC1=CC=CC=C1F VDDRKSVFMCGVKS-UHFFFAOYSA-N 0.000 claims description 2
• YCMRKXZMNUMKST-UHFFFAOYSA-N ethyl n-[2-amino-4-[(3,4-dichloroanilino)methyl]phenyl]carbamate Chemical compound C1=C(N)C(NC(=O)OCC)=CC=C1CNC1=CC=C(Cl)C(Cl)=C1 YCMRKXZMNUMKST-UHFFFAOYSA-N 0.000 claims description 2
• PJFKUBNCMZLCEL-UHFFFAOYSA-N ethyl n-[2-amino-4-[(3,4-difluoroanilino)methyl]phenyl]carbamate Chemical compound C1=C(N)C(NC(=O)OCC)=CC=C1CNC1=CC=C(F)C(F)=C1 PJFKUBNCMZLCEL-UHFFFAOYSA-N 0.000 claims description 2
• HFTMLRRJCMKHCO-UHFFFAOYSA-N ethyl n-[2-amino-4-[(3,5-dichloroanilino)methyl]phenyl]carbamate Chemical compound C1=C(N)C(NC(=O)OCC)=CC=C1CNC1=CC(Cl)=CC(Cl)=C1 HFTMLRRJCMKHCO-UHFFFAOYSA-N 0.000 claims description 2
• GXONDZRSDZSZRZ-UHFFFAOYSA-N ethyl n-[2-amino-4-[(3-chloro-4-methylanilino)methyl]phenyl]carbamate Chemical compound C1=C(N)C(NC(=O)OCC)=CC=C1CNC1=CC=C(C)C(Cl)=C1 GXONDZRSDZSZRZ-UHFFFAOYSA-N 0.000 claims description 2
• STCYUEYAARANPB-UHFFFAOYSA-N ethyl n-[2-amino-4-[(3-chloroanilino)methyl]phenyl]carbamate Chemical compound C1=C(N)C(NC(=O)OCC)=CC=C1CNC1=CC=CC(Cl)=C1 STCYUEYAARANPB-UHFFFAOYSA-N 0.000 claims description 2
• NGFUMNQGNPBYMN-UHFFFAOYSA-N ethyl n-[2-amino-4-[(3-chlorothiophen-2-yl)methylamino]phenyl]carbamate Chemical compound C1=C(N)C(NC(=O)OCC)=CC=C1NCC1=C(Cl)C=CS1 NGFUMNQGNPBYMN-UHFFFAOYSA-N 0.000 claims description 2
• RAVCWWJMYAMNLK-UHFFFAOYSA-N ethyl n-[2-amino-4-[(3-fluoroanilino)methyl]phenyl]carbamate Chemical compound C1=C(N)C(NC(=O)OCC)=CC=C1CNC1=CC=CC(F)=C1 RAVCWWJMYAMNLK-UHFFFAOYSA-N 0.000 claims description 2
• RNFBDOBYXLGUBY-UHFFFAOYSA-N ethyl n-[2-amino-4-[(3-methylanilino)methyl]phenyl]carbamate Chemical compound C1=C(N)C(NC(=O)OCC)=CC=C1CNC1=CC=CC(C)=C1 RNFBDOBYXLGUBY-UHFFFAOYSA-N 0.000 claims description 2
• QVJISOGPNWUYBI-UHFFFAOYSA-N ethyl n-[2-amino-4-[(3-methylthiophen-2-yl)methylamino]phenyl]carbamate Chemical compound C1=C(N)C(NC(=O)OCC)=CC=C1NCC1=C(C)C=CS1 QVJISOGPNWUYBI-UHFFFAOYSA-N 0.000 claims description 2
• BSQFTTSXMOOOGH-UHFFFAOYSA-N ethyl n-[2-amino-4-[(4-bromo-3-methoxythiophen-2-yl)methylamino]phenyl]carbamate Chemical compound C1=C(N)C(NC(=O)OCC)=CC=C1NCC1=C(OC)C(Br)=CS1 BSQFTTSXMOOOGH-UHFFFAOYSA-N 0.000 claims description 2
• HJHXJDJGCMMSGX-UHFFFAOYSA-N ethyl n-[2-amino-4-[(4-bromothiophen-2-yl)methylamino]phenyl]carbamate Chemical compound C1=C(N)C(NC(=O)OCC)=CC=C1NCC1=CC(Br)=CS1 HJHXJDJGCMMSGX-UHFFFAOYSA-N 0.000 claims description 2
• PZWXBOANAHDGDV-UHFFFAOYSA-N ethyl n-[2-amino-4-[(4-butylanilino)methyl]phenyl]carbamate Chemical compound C1=CC(CCCC)=CC=C1NCC1=CC=C(NC(=O)OCC)C(N)=C1 PZWXBOANAHDGDV-UHFFFAOYSA-N 0.000 claims description 2
• UACNDMSYYWUJNP-UHFFFAOYSA-N ethyl n-[2-amino-4-[(4-chloro-3-fluoroanilino)methyl]phenyl]carbamate Chemical compound C1=C(N)C(NC(=O)OCC)=CC=C1CNC1=CC=C(Cl)C(F)=C1 UACNDMSYYWUJNP-UHFFFAOYSA-N 0.000 claims description 2
• DWSPCTCHYKCYFR-UHFFFAOYSA-N ethyl n-[2-amino-4-[(4-chloroanilino)methyl]phenyl]carbamate Chemical compound C1=C(N)C(NC(=O)OCC)=CC=C1CNC1=CC=C(Cl)C=C1 DWSPCTCHYKCYFR-UHFFFAOYSA-N 0.000 claims description 2
• BYARLUNDODGUSF-UHFFFAOYSA-N ethyl n-[2-amino-4-[(4-cyanoanilino)methyl]phenyl]carbamate Chemical compound C1=C(N)C(NC(=O)OCC)=CC=C1CNC1=CC=C(C#N)C=C1 BYARLUNDODGUSF-UHFFFAOYSA-N 0.000 claims description 2
• LLYSQBCINNSNKO-UHFFFAOYSA-N ethyl n-[2-amino-4-[(4-cyclohexylanilino)methyl]phenyl]carbamate Chemical compound C1=C(N)C(NC(=O)OCC)=CC=C1CNC1=CC=C(C2CCCCC2)C=C1 LLYSQBCINNSNKO-UHFFFAOYSA-N 0.000 claims description 2
• NQNXMCDBIPXRFF-UHFFFAOYSA-N ethyl n-[2-amino-4-[(4-fluoroanilino)methyl]phenyl]carbamate Chemical compound C1=C(N)C(NC(=O)OCC)=CC=C1CNC1=CC=C(F)C=C1 NQNXMCDBIPXRFF-UHFFFAOYSA-N 0.000 claims description 2
• BSCJHOFVPMMXGC-UHFFFAOYSA-N ethyl n-[2-amino-4-[(4-methoxyanilino)methyl]phenyl]carbamate Chemical compound C1=C(N)C(NC(=O)OCC)=CC=C1CNC1=CC=C(OC)C=C1 BSCJHOFVPMMXGC-UHFFFAOYSA-N 0.000 claims description 2
• CIYWTQMAZIEXNG-UHFFFAOYSA-N ethyl n-[2-amino-4-[(4-methylanilino)methyl]phenyl]carbamate Chemical compound C1=C(N)C(NC(=O)OCC)=CC=C1CNC1=CC=C(C)C=C1 CIYWTQMAZIEXNG-UHFFFAOYSA-N 0.000 claims description 2
• NVOFZLPWTFWFDQ-UHFFFAOYSA-N ethyl n-[2-amino-4-[(4-phenylanilino)methyl]phenyl]carbamate Chemical compound C1=C(N)C(NC(=O)OCC)=CC=C1CNC1=CC=C(C=2C=CC=CC=2)C=C1 NVOFZLPWTFWFDQ-UHFFFAOYSA-N 0.000 claims description 2
• OVMRYCWHBHWHDB-UHFFFAOYSA-N ethyl n-[2-amino-4-[(4-propan-2-ylanilino)methyl]phenyl]carbamate Chemical compound C1=C(N)C(NC(=O)OCC)=CC=C1CNC1=CC=C(C(C)C)C=C1 OVMRYCWHBHWHDB-UHFFFAOYSA-N 0.000 claims description 2
• YGDMFPQYDCZIMM-UHFFFAOYSA-N ethyl n-[2-amino-4-[(4-tert-butylanilino)methyl]phenyl]carbamate Chemical compound C1=C(N)C(NC(=O)OCC)=CC=C1CNC1=CC=C(C(C)(C)C)C=C1 YGDMFPQYDCZIMM-UHFFFAOYSA-N 0.000 claims description 2
• WXSQDZHUDQVVFR-UHFFFAOYSA-N ethyl n-[2-amino-4-[(5-bromothiophen-2-yl)methylamino]phenyl]carbamate Chemical compound C1=C(N)C(NC(=O)OCC)=CC=C1NCC1=CC=C(Br)S1 WXSQDZHUDQVVFR-UHFFFAOYSA-N 0.000 claims description 2
• IJHUAAPUXUHKRF-UHFFFAOYSA-N ethyl n-[2-amino-4-[(5-chlorothiophen-2-yl)methyl-ethylamino]phenyl]carbamate Chemical compound C1=C(N)C(NC(=O)OCC)=CC=C1N(CC)CC1=CC=C(Cl)S1 IJHUAAPUXUHKRF-UHFFFAOYSA-N 0.000 claims description 2
• OWMAWWXIMWNHSI-UHFFFAOYSA-N ethyl n-[2-amino-4-[(5-chlorothiophen-2-yl)methyl-methylamino]phenyl]carbamate Chemical compound C1=C(N)C(NC(=O)OCC)=CC=C1N(C)CC1=CC=C(Cl)S1 OWMAWWXIMWNHSI-UHFFFAOYSA-N 0.000 claims description 2
• OCOIXRNXFUKTKY-UHFFFAOYSA-N ethyl n-[2-amino-4-[(5-ethylthiophen-2-yl)methylamino]phenyl]carbamate Chemical compound C1=C(N)C(NC(=O)OCC)=CC=C1NCC1=CC=C(CC)S1 OCOIXRNXFUKTKY-UHFFFAOYSA-N 0.000 claims description 2
• WIUHLNPDCTWFEH-UHFFFAOYSA-N ethyl n-[2-amino-4-[(5-fluoro-1-benzofuran-3-yl)methylamino]phenyl]carbamate Chemical compound C1=C(N)C(NC(=O)OCC)=CC=C1NCC1=COC2=CC=C(F)C=C12 WIUHLNPDCTWFEH-UHFFFAOYSA-N 0.000 claims description 2
• ITKAHTLJWIBUCZ-UHFFFAOYSA-N ethyl n-[2-amino-4-[(5-fluorothiophen-2-yl)methylamino]phenyl]carbamate Chemical compound C1=C(N)C(NC(=O)OCC)=CC=C1NCC1=CC=C(F)S1 ITKAHTLJWIBUCZ-UHFFFAOYSA-N 0.000 claims description 2
• HNUMRLQROUPWNJ-UHFFFAOYSA-N ethyl n-[2-amino-4-[(5-methylthiophen-2-yl)methylamino]phenyl]carbamate Chemical compound C1=C(N)C(NC(=O)OCC)=CC=C1NCC1=CC=C(C)S1 HNUMRLQROUPWNJ-UHFFFAOYSA-N 0.000 claims description 2
• PNYDZEMORIWFHF-UHFFFAOYSA-N ethyl n-[2-amino-4-[(5-phenylthiophen-2-yl)methylamino]phenyl]carbamate Chemical compound C1=C(N)C(NC(=O)OCC)=CC=C1NCC1=CC=C(C=2C=CC=CC=2)S1 PNYDZEMORIWFHF-UHFFFAOYSA-N 0.000 claims description 2
• IMAVPOSIWIUFQB-UHFFFAOYSA-N ethyl n-[2-amino-4-[(naphthalen-2-ylamino)methyl]phenyl]carbamate Chemical compound C1=C(N)C(NC(=O)OCC)=CC=C1CNC1=CC=C(C=CC=C2)C2=C1 IMAVPOSIWIUFQB-UHFFFAOYSA-N 0.000 claims description 2
• SHWHGZSYKAZUIB-UHFFFAOYSA-N ethyl n-[2-amino-4-[1-(4-chloroanilino)ethyl]phenyl]carbamate Chemical compound C1=C(N)C(NC(=O)OCC)=CC=C1C(C)NC1=CC=C(Cl)C=C1 SHWHGZSYKAZUIB-UHFFFAOYSA-N 0.000 claims description 2
• VRXUASWAYZPEHF-UHFFFAOYSA-N ethyl n-[2-amino-4-[1-[4-(trifluoromethyl)anilino]ethyl]phenyl]carbamate Chemical compound C1=C(N)C(NC(=O)OCC)=CC=C1C(C)NC1=CC=C(C(F)(F)F)C=C1 VRXUASWAYZPEHF-UHFFFAOYSA-N 0.000 claims description 2
• AEBTUIWNDWVQNE-UHFFFAOYSA-N ethyl n-[2-amino-4-[[3-(trifluoromethyl)anilino]methyl]phenyl]carbamate Chemical compound C1=C(N)C(NC(=O)OCC)=CC=C1CNC1=CC=CC(C(F)(F)F)=C1 AEBTUIWNDWVQNE-UHFFFAOYSA-N 0.000 claims description 2
• PYVCGNWJTVIAMS-UHFFFAOYSA-N ethyl n-[2-amino-4-[[3-fluoro-4-(trifluoromethyl)anilino]methyl]phenyl]carbamate Chemical compound C1=C(N)C(NC(=O)OCC)=CC=C1CNC1=CC=C(C(F)(F)F)C(F)=C1 PYVCGNWJTVIAMS-UHFFFAOYSA-N 0.000 claims description 2
• CBUCMNUGRUKIBK-UHFFFAOYSA-N ethyl n-[2-amino-4-[[4-(trifluoromethyl)anilino]methyl]phenyl]carbamate Chemical compound C1=C(N)C(NC(=O)OCC)=CC=C1CNC1=CC=C(C(F)(F)F)C=C1 CBUCMNUGRUKIBK-UHFFFAOYSA-N 0.000 claims description 2
• JFADARKTLVNWJT-UHFFFAOYSA-N ethyl n-[2-amino-4-[[4-fluoro-3-(trifluoromethyl)anilino]methyl]phenyl]carbamate Chemical compound C1=C(N)C(NC(=O)OCC)=CC=C1CNC1=CC=C(F)C(C(F)(F)F)=C1 JFADARKTLVNWJT-UHFFFAOYSA-N 0.000 claims description 2
• TWIJHCQVTIKQHL-UHFFFAOYSA-N ethyl n-[2-amino-4-[[5-(dimethylamino)-3-methyl-1-benzothiophen-2-yl]methylamino]phenyl]carbamate Chemical compound C1=C(N)C(NC(=O)OCC)=CC=C1NCC1=C(C)C2=CC(N(C)C)=CC=C2S1 TWIJHCQVTIKQHL-UHFFFAOYSA-N 0.000 claims description 2
• AQQQGRCQQUTKHH-UHFFFAOYSA-N ethyl n-[2-amino-4-[methyl-[(5-methylthiophen-2-yl)methyl]amino]phenyl]carbamate Chemical compound C1=C(N)C(NC(=O)OCC)=CC=C1N(C)CC1=CC=C(C)S1 AQQQGRCQQUTKHH-UHFFFAOYSA-N 0.000 claims description 2
• JFKOOJKAUOELLK-UHFFFAOYSA-N ethyl n-[2-amino-6-methyl-4-[[4-(trifluoromethyl)phenyl]methylamino]phenyl]carbamate Chemical compound C1=C(N)C(NC(=O)OCC)=C(C)C=C1NCC1=CC=C(C(F)(F)F)C=C1 JFKOOJKAUOELLK-UHFFFAOYSA-N 0.000 claims description 2
• PJQJLRQLLHQJMP-UHFFFAOYSA-N ethyl n-[2-chloro-4-[(3,4-dichloroanilino)methyl]phenyl]carbamate Chemical compound C1=C(Cl)C(NC(=O)OCC)=CC=C1CNC1=CC=C(Cl)C(Cl)=C1 PJQJLRQLLHQJMP-UHFFFAOYSA-N 0.000 claims description 2
• HIDMNWJFCJAMQI-UHFFFAOYSA-N ethyl n-[2-chloro-4-[(3-fluoroanilino)methyl]phenyl]carbamate Chemical compound C1=C(Cl)C(NC(=O)OCC)=CC=C1CNC1=CC=CC(F)=C1 HIDMNWJFCJAMQI-UHFFFAOYSA-N 0.000 claims description 2
• YZOXDNFQASBYLT-UHFFFAOYSA-N ethyl n-[2-chloro-4-[(4-chloro-3-fluoroanilino)methyl]phenyl]carbamate Chemical compound C1=C(Cl)C(NC(=O)OCC)=CC=C1CNC1=CC=C(Cl)C(F)=C1 YZOXDNFQASBYLT-UHFFFAOYSA-N 0.000 claims description 2
• URAKWDASUSFXKH-UHFFFAOYSA-N ethyl n-[2-chloro-4-[(4-chloroanilino)methyl]phenyl]carbamate Chemical compound C1=C(Cl)C(NC(=O)OCC)=CC=C1CNC1=CC=C(Cl)C=C1 URAKWDASUSFXKH-UHFFFAOYSA-N 0.000 claims description 2
• XPAYAFCWAGCEME-UHFFFAOYSA-N ethyl n-[2-chloro-4-[(4-fluoroanilino)methyl]phenyl]carbamate Chemical compound C1=C(Cl)C(NC(=O)OCC)=CC=C1CNC1=CC=C(F)C=C1 XPAYAFCWAGCEME-UHFFFAOYSA-N 0.000 claims description 2
• AMWAUBYTNYONBR-UHFFFAOYSA-N ethyl n-[2-chloro-4-[(4-propan-2-ylphenyl)methylamino]phenyl]carbamate Chemical compound C1=C(Cl)C(NC(=O)OCC)=CC=C1NCC1=CC=C(C(C)C)C=C1 AMWAUBYTNYONBR-UHFFFAOYSA-N 0.000 claims description 2
• UJHAKAHMBMEMNW-UHFFFAOYSA-N ethyl n-[2-chloro-4-[(5-chlorothiophen-2-yl)methylamino]phenyl]carbamate Chemical compound C1=C(Cl)C(NC(=O)OCC)=CC=C1NCC1=CC=C(Cl)S1 UJHAKAHMBMEMNW-UHFFFAOYSA-N 0.000 claims description 2
• UVHHGQGCILHVPA-UHFFFAOYSA-N ethyl n-[2-chloro-4-[methyl-[(4-methylsulfanylphenyl)methyl]amino]phenyl]carbamate Chemical compound C1=C(Cl)C(NC(=O)OCC)=CC=C1N(C)CC1=CC=C(SC)C=C1 UVHHGQGCILHVPA-UHFFFAOYSA-N 0.000 claims description 2
• PXJYWPAJYQOYAU-UHFFFAOYSA-N ethyl n-[2-chloro-4-[methyl-[[4-(trifluoromethyl)phenyl]methyl]amino]phenyl]carbamate Chemical compound C1=C(Cl)C(NC(=O)OCC)=CC=C1N(C)CC1=CC=C(C(F)(F)F)C=C1 PXJYWPAJYQOYAU-UHFFFAOYSA-N 0.000 claims description 2
• MTYCZZYJZDRZKZ-UHFFFAOYSA-N ethyl n-[2-cyano-4-[(4-propan-2-ylphenyl)methylamino]phenyl]carbamate Chemical compound C1=C(C#N)C(NC(=O)OCC)=CC=C1NCC1=CC=C(C(C)C)C=C1 MTYCZZYJZDRZKZ-UHFFFAOYSA-N 0.000 claims description 2
• FBWLGGCIJQPAGG-UHFFFAOYSA-N ethyl n-[2-fluoro-4-[[4-(trifluoromethyl)anilino]methyl]phenyl]carbamate Chemical compound C1=C(F)C(NC(=O)OCC)=CC=C1CNC1=CC=C(C(F)(F)F)C=C1 FBWLGGCIJQPAGG-UHFFFAOYSA-N 0.000 claims description 2
• HIFLWUPIVYIOKB-UHFFFAOYSA-N ethyl n-[2-methoxy-4-[(3-methylthiophen-2-yl)methylamino]phenyl]carbamate Chemical compound C1=C(OC)C(NC(=O)OCC)=CC=C1NCC1=C(C)C=CS1 HIFLWUPIVYIOKB-UHFFFAOYSA-N 0.000 claims description 2
• DBGKFRUFUABFLM-UHFFFAOYSA-N ethyl n-[2-methoxy-4-[(4-propan-2-ylphenyl)methylamino]phenyl]carbamate Chemical compound C1=C(OC)C(NC(=O)OCC)=CC=C1NCC1=CC=C(C(C)C)C=C1 DBGKFRUFUABFLM-UHFFFAOYSA-N 0.000 claims description 2
• GPLMHGDAOVFNCU-UHFFFAOYSA-N ethyl n-[2-methyl-4-[(4-propan-2-ylphenyl)methylamino]phenyl]carbamate Chemical compound C1=C(C)C(NC(=O)OCC)=CC=C1NCC1=CC=C(C(C)C)C=C1 GPLMHGDAOVFNCU-UHFFFAOYSA-N 0.000 claims description 2
• VLIKNAITKKRTJV-UHFFFAOYSA-N ethyl n-[2-methyl-4-[(5-phenylthiophen-2-yl)methylamino]phenyl]carbamate Chemical compound C1=C(C)C(NC(=O)OCC)=CC=C1NCC1=CC=C(C=2C=CC=CC=2)S1 VLIKNAITKKRTJV-UHFFFAOYSA-N 0.000 claims description 2
• YETJUQCNPAAANG-UHFFFAOYSA-N ethyl n-[2-methyl-4-[[4-(trifluoromethyl)anilino]methyl]phenyl]carbamate Chemical compound C1=C(C)C(NC(=O)OCC)=CC=C1CNC1=CC=C(C(F)(F)F)C=C1 YETJUQCNPAAANG-UHFFFAOYSA-N 0.000 claims description 2
• FJGJSYHAKOHFMZ-UHFFFAOYSA-N ethyl n-[2-methyl-4-[[4-(trifluoromethyl)phenyl]methylamino]phenyl]carbamate Chemical compound C1=C(C)C(NC(=O)OCC)=CC=C1NCC1=CC=C(C(F)(F)F)C=C1 FJGJSYHAKOHFMZ-UHFFFAOYSA-N 0.000 claims description 2
• XYIVNKLPSJLTHT-UHFFFAOYSA-N ethyl n-[4-(1,3-benzodioxol-5-ylmethylamino)-2-propan-2-yloxyphenyl]carbamate Chemical compound C1=C(OC(C)C)C(NC(=O)OCC)=CC=C1NCC1=CC=C(OCO2)C2=C1 XYIVNKLPSJLTHT-UHFFFAOYSA-N 0.000 claims description 2
• LBPNSUIVYSELKA-UHFFFAOYSA-N ethyl n-[4-(1-benzothiophen-2-ylmethylamino)-2-chlorophenyl]carbamate Chemical compound C1=C(Cl)C(NC(=O)OCC)=CC=C1NCC1=CC2=CC=CC=C2S1 LBPNSUIVYSELKA-UHFFFAOYSA-N 0.000 claims description 2
• MBZCXPYDDKNMKD-UHFFFAOYSA-N ethyl n-[4-(1-benzothiophen-2-ylmethylamino)-2-methylphenyl]carbamate Chemical compound C1=C(C)C(NC(=O)OCC)=CC=C1NCC1=CC2=CC=CC=C2S1 MBZCXPYDDKNMKD-UHFFFAOYSA-N 0.000 claims description 2
• DTOYTZIERSGENB-UHFFFAOYSA-N ethyl n-[4-(1-benzothiophen-3-ylmethylamino)-2-cyclopentyloxyphenyl]carbamate Chemical compound CCOC(=O)NC1=CC=C(NCC=2C3=CC=CC=C3SC=2)C=C1OC1CCCC1 DTOYTZIERSGENB-UHFFFAOYSA-N 0.000 claims description 2
• XDKSFHCRKBLVPN-UHFFFAOYSA-N ethyl n-[4-[(2,4-difluorophenyl)methylamino]-2-methoxyphenyl]carbamate Chemical compound C1=C(OC)C(NC(=O)OCC)=CC=C1NCC1=CC=C(F)C=C1F XDKSFHCRKBLVPN-UHFFFAOYSA-N 0.000 claims description 2
• PSRTZGHRXNJOEO-UHFFFAOYSA-N ethyl n-[4-[(3,4-difluoroanilino)methyl]-2-methylphenyl]carbamate Chemical compound C1=C(C)C(NC(=O)OCC)=CC=C1CNC1=CC=C(F)C(F)=C1 PSRTZGHRXNJOEO-UHFFFAOYSA-N 0.000 claims description 2
• DHNIHGLWXHLYGU-UHFFFAOYSA-N ethyl n-[4-[(3-fluoro-2-methylphenyl)methylamino]-2-(2-phenylethoxy)phenyl]carbamate Chemical compound C1=C(OCCC=2C=CC=CC=2)C(NC(=O)OCC)=CC=C1NCC1=CC=CC(F)=C1C DHNIHGLWXHLYGU-UHFFFAOYSA-N 0.000 claims description 2
• DDLKIMUNVILAIR-UHFFFAOYSA-N ethyl n-[4-[(3-fluoro-2-methylphenyl)methylamino]-2-phenylmethoxyphenyl]carbamate Chemical compound C1=C(OCC=2C=CC=CC=2)C(NC(=O)OCC)=CC=C1NCC1=CC=CC(F)=C1C DDLKIMUNVILAIR-UHFFFAOYSA-N 0.000 claims description 2
• CVTJQRXEUAZWTQ-UHFFFAOYSA-N ethyl n-[4-[(3-fluoro-2-methylphenyl)methylamino]-2-propan-2-yloxyphenyl]carbamate Chemical compound C1=C(OC(C)C)C(NC(=O)OCC)=CC=C1NCC1=CC=CC(F)=C1C CVTJQRXEUAZWTQ-UHFFFAOYSA-N 0.000 claims description 2
• QEYNFGCIULPLPC-UHFFFAOYSA-N ethyl n-[4-[(3-fluoroanilino)methyl]-2,6-dimethylphenyl]carbamate Chemical compound C1=C(C)C(NC(=O)OCC)=C(C)C=C1CNC1=CC=CC(F)=C1 QEYNFGCIULPLPC-UHFFFAOYSA-N 0.000 claims description 2
• YFYLMPIYVCSHPH-UHFFFAOYSA-N ethyl n-[4-[(3-fluoroanilino)methyl]-2-methylphenyl]carbamate Chemical compound C1=C(C)C(NC(=O)OCC)=CC=C1CNC1=CC=CC(F)=C1 YFYLMPIYVCSHPH-UHFFFAOYSA-N 0.000 claims description 2
• IMLUDSPLHDRIPO-UHFFFAOYSA-N ethyl n-[4-[(3-fluorophenyl)methylamino]-2-methoxyphenyl]carbamate Chemical compound C1=C(OC)C(NC(=O)OCC)=CC=C1NCC1=CC=CC(F)=C1 IMLUDSPLHDRIPO-UHFFFAOYSA-N 0.000 claims description 2
• LCEODKNUZATZLW-UHFFFAOYSA-N ethyl n-[4-[(3-methoxyphenyl)methylamino]-2-phenylmethoxyphenyl]carbamate Chemical compound C1=C(OCC=2C=CC=CC=2)C(NC(=O)OCC)=CC=C1NCC1=CC=CC(OC)=C1 LCEODKNUZATZLW-UHFFFAOYSA-N 0.000 claims description 2
• TZNQYORNTRQEJV-UHFFFAOYSA-N ethyl n-[4-[(4-chloro-3-fluoroanilino)methyl]-2-fluorophenyl]carbamate Chemical compound C1=C(F)C(NC(=O)OCC)=CC=C1CNC1=CC=C(Cl)C(F)=C1 TZNQYORNTRQEJV-UHFFFAOYSA-N 0.000 claims description 2
• RUVLMXALVIBXME-UHFFFAOYSA-N ethyl n-[4-[(4-chloroanilino)methyl]-2-fluorophenyl]carbamate Chemical compound C1=C(F)C(NC(=O)OCC)=CC=C1CNC1=CC=C(Cl)C=C1 RUVLMXALVIBXME-UHFFFAOYSA-N 0.000 claims description 2
• DPIDNSCETUXASM-UHFFFAOYSA-N ethyl n-[4-[(4-chloroanilino)methyl]-2-methylphenyl]carbamate Chemical compound C1=C(C)C(NC(=O)OCC)=CC=C1CNC1=CC=C(Cl)C=C1 DPIDNSCETUXASM-UHFFFAOYSA-N 0.000 claims description 2
• JRMWXXMVCOHXCB-UHFFFAOYSA-N ethyl n-[4-[(4-chloroanilino)methyl]phenyl]carbamate Chemical compound C1=CC(NC(=O)OCC)=CC=C1CNC1=CC=C(Cl)C=C1 JRMWXXMVCOHXCB-UHFFFAOYSA-N 0.000 claims description 2
• QCEHDLKQWVGPFI-UHFFFAOYSA-N ethyl n-[4-[(4-chlorophenyl)methylamino]-2-methylphenyl]carbamate Chemical compound C1=C(C)C(NC(=O)OCC)=CC=C1NCC1=CC=C(Cl)C=C1 QCEHDLKQWVGPFI-UHFFFAOYSA-N 0.000 claims description 2
• HCLUFHIOGAXFCC-UHFFFAOYSA-N ethyl n-[4-[(4-fluoroanilino)methyl]-2-methylphenyl]carbamate Chemical compound C1=C(C)C(NC(=O)OCC)=CC=C1CNC1=CC=C(F)C=C1 HCLUFHIOGAXFCC-UHFFFAOYSA-N 0.000 claims description 2
• NWLXPWFNBKJVKX-UHFFFAOYSA-N ethyl n-[4-[(4-fluorophenyl)methyl-methylamino]-2-propan-2-yloxyphenyl]carbamate Chemical compound C1=C(OC(C)C)C(NC(=O)OCC)=CC=C1N(C)CC1=CC=C(F)C=C1 NWLXPWFNBKJVKX-UHFFFAOYSA-N 0.000 claims description 2
• XKSCLMWYIAIGGH-UHFFFAOYSA-N ethyl n-[4-[(4-methylsulfanylphenyl)methylamino]-2-(trifluoromethyl)phenyl]carbamate Chemical compound C1=C(C(F)(F)F)C(NC(=O)OCC)=CC=C1NCC1=CC=C(SC)C=C1 XKSCLMWYIAIGGH-UHFFFAOYSA-N 0.000 claims description 2
• FUOWMPZQNQMKQJ-UHFFFAOYSA-N ethyl n-[4-[(4-methylsulfanylphenyl)methylamino]-2-phenylmethoxyphenyl]carbamate Chemical compound C1=C(OCC=2C=CC=CC=2)C(NC(=O)OCC)=CC=C1NCC1=CC=C(SC)C=C1 FUOWMPZQNQMKQJ-UHFFFAOYSA-N 0.000 claims description 2
• KKLHNPWQODPAQP-UHFFFAOYSA-N ethyl n-[4-[(4-tert-butylphenyl)methyl-methylamino]-2-(trifluoromethyl)phenyl]carbamate Chemical compound C1=C(C(F)(F)F)C(NC(=O)OCC)=CC=C1N(C)CC1=CC=C(C(C)(C)C)C=C1 KKLHNPWQODPAQP-UHFFFAOYSA-N 0.000 claims description 2
• AYJLXGFLEJCNSS-UHFFFAOYSA-N ethyl n-[4-[(4-tert-butylphenyl)methyl-methylamino]-2-chlorophenyl]carbamate Chemical compound C1=C(Cl)C(NC(=O)OCC)=CC=C1N(C)CC1=CC=C(C(C)(C)C)C=C1 AYJLXGFLEJCNSS-UHFFFAOYSA-N 0.000 claims description 2
• JHNNJXNHEUWQQI-UHFFFAOYSA-N ethyl n-[4-[(4-tert-butylphenyl)methylamino]-2-(trifluoromethyl)phenyl]carbamate Chemical compound C1=C(C(F)(F)F)C(NC(=O)OCC)=CC=C1NCC1=CC=C(C(C)(C)C)C=C1 JHNNJXNHEUWQQI-UHFFFAOYSA-N 0.000 claims description 2
• LZCPHDBEDLLPCH-UHFFFAOYSA-N ethyl n-[4-[(5-bromothiophen-2-yl)methyl-methylamino]-2-(trifluoromethyl)phenyl]carbamate Chemical compound C1=C(C(F)(F)F)C(NC(=O)OCC)=CC=C1N(C)CC1=CC=C(Br)S1 LZCPHDBEDLLPCH-UHFFFAOYSA-N 0.000 claims description 2
• CZIYBKSESQHEMY-UHFFFAOYSA-N ethyl n-[4-[(5-bromothiophen-2-yl)methylamino]-2-(trifluoromethyl)phenyl]carbamate Chemical compound C1=C(C(F)(F)F)C(NC(=O)OCC)=CC=C1NCC1=CC=C(Br)S1 CZIYBKSESQHEMY-UHFFFAOYSA-N 0.000 claims description 2
• BNRZQCLVVKMSIW-UHFFFAOYSA-N ethyl n-[4-[(5-bromothiophen-2-yl)methylamino]-2-chlorophenyl]carbamate Chemical compound C1=C(Cl)C(NC(=O)OCC)=CC=C1NCC1=CC=C(Br)S1 BNRZQCLVVKMSIW-UHFFFAOYSA-N 0.000 claims description 2
• URCRJUUPLVVVDL-UHFFFAOYSA-N ethyl n-[4-[(5-chlorothiophen-2-yl)methyl-methylamino]-2-(trifluoromethyl)phenyl]carbamate Chemical compound C1=C(C(F)(F)F)C(NC(=O)OCC)=CC=C1N(C)CC1=CC=C(Cl)S1 URCRJUUPLVVVDL-UHFFFAOYSA-N 0.000 claims description 2
• AKLXLTKONNDHHV-UHFFFAOYSA-N ethyl n-[4-[(5-chlorothiophen-2-yl)methylamino]-2-(6-methoxypyridin-3-yl)phenyl]carbamate Chemical compound C1=C(C=2C=NC(OC)=CC=2)C(NC(=O)OCC)=CC=C1NCC1=CC=C(Cl)S1 AKLXLTKONNDHHV-UHFFFAOYSA-N 0.000 claims description 2
• JBIFACVOFRVYLT-UHFFFAOYSA-N ethyl n-[4-[(5-chlorothiophen-2-yl)methylamino]-2-(trifluoromethyl)phenyl]carbamate Chemical compound C1=C(C(F)(F)F)C(NC(=O)OCC)=CC=C1NCC1=CC=C(Cl)S1 JBIFACVOFRVYLT-UHFFFAOYSA-N 0.000 claims description 2
• XXUITLDPXQQWMX-UHFFFAOYSA-N ethyl n-[4-[(5-chlorothiophen-2-yl)methylamino]-2-cyanophenyl]carbamate Chemical compound C1=C(C#N)C(NC(=O)OCC)=CC=C1NCC1=CC=C(Cl)S1 XXUITLDPXQQWMX-UHFFFAOYSA-N 0.000 claims description 2
• PPNRDWUDMHIESH-UHFFFAOYSA-N ethyl n-[4-[(5-chlorothiophen-2-yl)methylamino]-2-iodophenyl]carbamate Chemical compound C1=C(I)C(NC(=O)OCC)=CC=C1NCC1=CC=C(Cl)S1 PPNRDWUDMHIESH-UHFFFAOYSA-N 0.000 claims description 2
• ZWTUCGJBUWCVJO-UHFFFAOYSA-N ethyl n-[4-[(5-chlorothiophen-2-yl)methylamino]-2-methylphenyl]carbamate Chemical compound C1=C(C)C(NC(=O)OCC)=CC=C1NCC1=CC=C(Cl)S1 ZWTUCGJBUWCVJO-UHFFFAOYSA-N 0.000 claims description 2
• BHONFRQFLYRMJR-UHFFFAOYSA-N ethyl n-[4-[(5-chlorothiophen-2-yl)methylamino]-2-pyridin-3-ylphenyl]carbamate Chemical compound C1=C(C=2C=NC=CC=2)C(NC(=O)OCC)=CC=C1NCC1=CC=C(Cl)S1 BHONFRQFLYRMJR-UHFFFAOYSA-N 0.000 claims description 2
• HWRLUDVUXQLMIH-UHFFFAOYSA-N ethyl n-[4-[(5-chlorothiophen-2-yl)methylamino]-2-pyridin-4-ylphenyl]carbamate Chemical compound C1=C(C=2C=CN=CC=2)C(NC(=O)OCC)=CC=C1NCC1=CC=C(Cl)S1 HWRLUDVUXQLMIH-UHFFFAOYSA-N 0.000 claims description 2
• PCPKDKGFFJFEJT-UHFFFAOYSA-N ethyl n-[4-[(5-chlorothiophen-2-yl)methylamino]-2-quinolin-3-ylphenyl]carbamate Chemical compound C1=C(C=2C=C3C=CC=CC3=NC=2)C(NC(=O)OCC)=CC=C1NCC1=CC=C(Cl)S1 PCPKDKGFFJFEJT-UHFFFAOYSA-N 0.000 claims description 2
• NIEWPONKIRMTPH-UHFFFAOYSA-N ethyl n-[4-[(6-methoxy-1-benzothiophen-2-yl)methylamino]-2-methylphenyl]carbamate Chemical compound C1=C(C)C(NC(=O)OCC)=CC=C1NCC1=CC2=CC=C(OC)C=C2S1 NIEWPONKIRMTPH-UHFFFAOYSA-N 0.000 claims description 2
• UNHRXQWFNONDJR-UHFFFAOYSA-N ethyl n-[4-[1-(4-chloroanilino)ethyl]phenyl]carbamate Chemical compound C1=CC(NC(=O)OCC)=CC=C1C(C)NC1=CC=C(Cl)C=C1 UNHRXQWFNONDJR-UHFFFAOYSA-N 0.000 claims description 2
• KLNBESIFXRZEPF-UHFFFAOYSA-N ethyl n-[4-[[3-fluoro-4-(trifluoromethyl)phenyl]methylamino]-2-methylphenyl]carbamate Chemical compound C1=C(C)C(NC(=O)OCC)=CC=C1NCC1=CC=C(C(F)(F)F)C(F)=C1 KLNBESIFXRZEPF-UHFFFAOYSA-N 0.000 claims description 2
• GCFCPEZENZTFAY-UHFFFAOYSA-N ethyl n-[4-[[4-(trifluoromethyl)anilino]methyl]phenyl]carbamate Chemical compound C1=CC(NC(=O)OCC)=CC=C1CNC1=CC=C(C(F)(F)F)C=C1 GCFCPEZENZTFAY-UHFFFAOYSA-N 0.000 claims description 2
• GAYMQGPGTVLOQU-UHFFFAOYSA-N ethyl n-[4-[methyl-[(4-methylsulfanylphenyl)methyl]amino]-2-(trifluoromethyl)phenyl]carbamate Chemical compound C1=C(C(F)(F)F)C(NC(=O)OCC)=CC=C1N(C)CC1=CC=C(SC)C=C1 GAYMQGPGTVLOQU-UHFFFAOYSA-N 0.000 claims description 2
• IMUOXPRZLBQDQK-UHFFFAOYSA-N ethyl n-[4-[methyl-[(4-propan-2-ylphenyl)methyl]amino]-2-(trifluoromethyl)phenyl]carbamate Chemical compound C1=C(C(F)(F)F)C(NC(=O)OCC)=CC=C1N(C)CC1=CC=C(C(C)C)C=C1 IMUOXPRZLBQDQK-UHFFFAOYSA-N 0.000 claims description 2
• LUCIULMHEDDUDH-UHFFFAOYSA-N ethyl n-[4-[methyl-[[4-(trifluoromethyl)phenyl]methyl]amino]-2-(trifluoromethyl)phenyl]carbamate Chemical compound C1=C(C(F)(F)F)C(NC(=O)OCC)=CC=C1N(C)CC1=CC=C(C(F)(F)F)C=C1 LUCIULMHEDDUDH-UHFFFAOYSA-N 0.000 claims description 2
• JLNYLDRCNCLJQY-UHFFFAOYSA-N hexyl n-[2-chloro-4-[(5-chlorothiophen-2-yl)methyl-methylamino]phenyl]carbamate Chemical compound C1=C(Cl)C(NC(=O)OCCCCCC)=CC=C1N(C)CC1=CC=C(Cl)S1 JLNYLDRCNCLJQY-UHFFFAOYSA-N 0.000 claims description 2
• 230000008449 language Effects 0.000 claims description 2
• 230000001404 mediated effect Effects 0.000 claims description 2
• ZWBZSWWTAABAAW-UHFFFAOYSA-N methyl 3-[4-[(5-chlorothiophen-2-yl)methyl-methylamino]-2-methylanilino]-3-oxopropanoate Chemical compound C1=C(C)C(NC(=O)CC(=O)OC)=CC=C1N(C)CC1=CC=C(Cl)S1 ZWBZSWWTAABAAW-UHFFFAOYSA-N 0.000 claims description 2
• GIOTXFVSHZODRM-UHFFFAOYSA-N methyl 4-[[3-methyl-4-(propoxycarbonylamino)anilino]methyl]benzoate Chemical compound C1=C(C)C(NC(=O)OCCC)=CC=C1NCC1=CC=C(C(=O)OC)C=C1 GIOTXFVSHZODRM-UHFFFAOYSA-N 0.000 claims description 2
• ZRCLMLJAAYQKFH-UHFFFAOYSA-N methyl n-[4-(1-benzothiophen-2-ylmethylamino)-2-methoxyphenyl]carbamate Chemical compound C1=C(OC)C(NC(=O)OC)=CC=C1NCC1=CC2=CC=CC=C2S1 ZRCLMLJAAYQKFH-UHFFFAOYSA-N 0.000 claims description 2
• NSXYSIRPQHZGRS-UHFFFAOYSA-N n-(2,4-dimethyl-6-morpholin-4-ylpyridin-3-yl)-2-(3,4-dimethylphenyl)acetamide Chemical compound C1=C(C)C(C)=CC=C1CC(=O)NC1=C(C)C=C(N2CCOCC2)N=C1C NSXYSIRPQHZGRS-UHFFFAOYSA-N 0.000 claims description 2
• QFXOZVHCESXJLE-UHFFFAOYSA-N n-(2,4-dimethyl-6-morpholin-4-ylpyridin-3-yl)-2-(3,5-dimethylphenyl)acetamide Chemical compound CC1=CC(C)=CC(CC(=O)NC=2C(=NC(=CC=2C)N2CCOCC2)C)=C1 QFXOZVHCESXJLE-UHFFFAOYSA-N 0.000 claims description 2
• LNHWKNMHQDEDHA-UHFFFAOYSA-N n-(2,4-dimethyl-6-morpholin-4-ylpyridin-3-yl)-2-(3-fluorophenyl)acetamide Chemical compound CC1=CC(N2CCOCC2)=NC(C)=C1NC(=O)CC1=CC=CC(F)=C1 LNHWKNMHQDEDHA-UHFFFAOYSA-N 0.000 claims description 2
• MTXSFPSKHDODED-UHFFFAOYSA-N n-(2,4-dimethyl-6-morpholin-4-ylpyridin-3-yl)-2-(3-methylphenyl)acetamide Chemical compound CC1=CC=CC(CC(=O)NC=2C(=NC(=CC=2C)N2CCOCC2)C)=C1 MTXSFPSKHDODED-UHFFFAOYSA-N 0.000 claims description 2
• LXXQJPDIABMXEO-UHFFFAOYSA-N n-(2,4-dimethyl-6-morpholin-4-ylpyridin-3-yl)-2-(4-fluorophenyl)acetamide Chemical compound CC1=CC(N2CCOCC2)=NC(C)=C1NC(=O)CC1=CC=C(F)C=C1 LXXQJPDIABMXEO-UHFFFAOYSA-N 0.000 claims description 2
• RVOCAYGOJGYTFK-UHFFFAOYSA-N n-(2,4-dimethyl-6-morpholin-4-ylpyridin-3-yl)-2-(4-methoxy-3-methylphenyl)acetamide Chemical compound C1=C(C)C(OC)=CC=C1CC(=O)NC1=C(C)C=C(N2CCOCC2)N=C1C RVOCAYGOJGYTFK-UHFFFAOYSA-N 0.000 claims description 2
• ZWAWWLRQLGIARH-UHFFFAOYSA-N n-(2,4-dimethyl-6-morpholin-4-ylpyridin-3-yl)-2-(4-methoxyphenyl)acetamide Chemical compound C1=CC(OC)=CC=C1CC(=O)NC1=C(C)C=C(N2CCOCC2)N=C1C ZWAWWLRQLGIARH-UHFFFAOYSA-N 0.000 claims description 2
• ZZQZQXDYSRXASP-UHFFFAOYSA-N n-(2,4-dimethyl-6-morpholin-4-ylpyridin-3-yl)-2-(4-methylphenyl)acetamide Chemical compound C1=CC(C)=CC=C1CC(=O)NC1=C(C)C=C(N2CCOCC2)N=C1C ZZQZQXDYSRXASP-UHFFFAOYSA-N 0.000 claims description 2
• OEMGVWLOWRPQLL-UHFFFAOYSA-N n-(2,4-dimethyl-6-morpholin-4-ylpyridin-3-yl)-2-[3-(trifluoromethyl)phenyl]acetamide Chemical compound CC1=CC(N2CCOCC2)=NC(C)=C1NC(=O)CC1=CC=CC(C(F)(F)F)=C1 OEMGVWLOWRPQLL-UHFFFAOYSA-N 0.000 claims description 2
• GKDVUJSUFGQXKA-UHFFFAOYSA-N n-(2,4-dimethyl-6-morpholin-4-ylpyridin-3-yl)-2-naphthalen-2-ylacetamide Chemical compound N=1C(C)=C(NC(=O)CC=2C=C3C=CC=CC3=CC=2)C(C)=CC=1N1CCOCC1 GKDVUJSUFGQXKA-UHFFFAOYSA-N 0.000 claims description 2
• LOCRXXVELNBLQE-UHFFFAOYSA-N n-(2,4-dimethyl-6-morpholin-4-ylpyridin-3-yl)-2-phenylacetamide Chemical compound CC1=CC(N2CCOCC2)=NC(C)=C1NC(=O)CC1=CC=CC=C1 LOCRXXVELNBLQE-UHFFFAOYSA-N 0.000 claims description 2
• MRNPWIWBKMYBTH-UHFFFAOYSA-N n-(2,4-dimethyl-6-morpholin-4-ylpyridin-3-yl)-2-phenylcyclopropane-1-carboxamide Chemical compound CC1=CC(N2CCOCC2)=NC(C)=C1NC(=O)C1CC1C1=CC=CC=C1 MRNPWIWBKMYBTH-UHFFFAOYSA-N 0.000 claims description 2
• VRDZAGWZCGIZSC-UHFFFAOYSA-N n-(2,4-dimethyl-6-morpholin-4-ylpyridin-3-yl)-2-thiophen-2-ylacetamide Chemical compound CC1=CC(N2CCOCC2)=NC(C)=C1NC(=O)CC1=CC=CS1 VRDZAGWZCGIZSC-UHFFFAOYSA-N 0.000 claims description 2
• ZBQQCPVAXQILBE-UHFFFAOYSA-N n-(2,4-dimethyl-6-morpholin-4-ylpyridin-3-yl)-2-thiophen-3-ylacetamide Chemical compound CC1=CC(N2CCOCC2)=NC(C)=C1NC(=O)CC=1C=CSC=1 ZBQQCPVAXQILBE-UHFFFAOYSA-N 0.000 claims description 2
• WVSKXMHDWLIKIR-UHFFFAOYSA-N n-(2,4-dimethyl-6-morpholin-4-ylpyridin-3-yl)-3,5,5-trimethylhexanamide Chemical compound N1=C(C)C(NC(=O)CC(C)CC(C)(C)C)=C(C)C=C1N1CCOCC1 WVSKXMHDWLIKIR-UHFFFAOYSA-N 0.000 claims description 2
• KAKNMOGUWPXQFL-UHFFFAOYSA-N n-(2,4-dimethyl-6-morpholin-4-ylpyridin-3-yl)-3-(4-methoxyphenyl)propanamide Chemical compound C1=CC(OC)=CC=C1CCC(=O)NC1=C(C)C=C(N2CCOCC2)N=C1C KAKNMOGUWPXQFL-UHFFFAOYSA-N 0.000 claims description 2
• OFNMXZJAGVKVKO-UHFFFAOYSA-N n-(2,4-dimethyl-6-morpholin-4-ylpyridin-3-yl)-3-(4-methylphenyl)propanamide Chemical compound C1=CC(C)=CC=C1CCC(=O)NC1=C(C)C=C(N2CCOCC2)N=C1C OFNMXZJAGVKVKO-UHFFFAOYSA-N 0.000 claims description 2
• BLESCNKLEXGCBO-UHFFFAOYSA-N n-(2,4-dimethyl-6-morpholin-4-ylpyridin-3-yl)-4-methylpentanamide Chemical compound N1=C(C)C(NC(=O)CCC(C)C)=C(C)C=C1N1CCOCC1 BLESCNKLEXGCBO-UHFFFAOYSA-N 0.000 claims description 2
• LRPPLNWCCXUMIQ-UHFFFAOYSA-N n-(2,4-dimethyl-6-morpholin-4-ylpyridin-3-yl)-5-methylhexanamide Chemical compound N1=C(C)C(NC(=O)CCCC(C)C)=C(C)C=C1N1CCOCC1 LRPPLNWCCXUMIQ-UHFFFAOYSA-N 0.000 claims description 2
• RZPBJOUKSLGPAK-UHFFFAOYSA-N n-(2,4-dimethyl-6-morpholin-4-ylpyridin-3-yl)heptanamide Chemical compound N1=C(C)C(NC(=O)CCCCCC)=C(C)C=C1N1CCOCC1 RZPBJOUKSLGPAK-UHFFFAOYSA-N 0.000 claims description 2
• QHRDANBBSJKUAT-UHFFFAOYSA-N n-(2,4-dimethyl-6-morpholin-4-ylpyridin-3-yl)octanamide Chemical compound N1=C(C)C(NC(=O)CCCCCCC)=C(C)C=C1N1CCOCC1 QHRDANBBSJKUAT-UHFFFAOYSA-N 0.000 claims description 2
• UANXUOHOUIPKAT-UHFFFAOYSA-N n-(2,4-dimethyl-6-quinolin-3-ylphenyl)-2-(4-fluorophenyl)acetamide Chemical compound C=1N=C2C=CC=CC2=CC=1C1=CC(C)=CC(C)=C1NC(=O)CC1=CC=C(F)C=C1 UANXUOHOUIPKAT-UHFFFAOYSA-N 0.000 claims description 2
• QFBRGGLYIZJDNP-UHFFFAOYSA-N n-(2,6-difluoro-4-morpholin-4-ylphenyl)-2-(3-fluorophenyl)acetamide Chemical compound FC1=CC=CC(CC(=O)NC=2C(=CC(=CC=2F)N2CCOCC2)F)=C1 QFBRGGLYIZJDNP-UHFFFAOYSA-N 0.000 claims description 2
• PCQHZOFRMZIDSO-UHFFFAOYSA-N n-(2,6-difluoro-4-morpholin-4-ylphenyl)-3,3-dimethylbutanamide Chemical compound C1=C(F)C(NC(=O)CC(C)(C)C)=C(F)C=C1N1CCOCC1 PCQHZOFRMZIDSO-UHFFFAOYSA-N 0.000 claims description 2
• RQMWEJOBHGLLHJ-UHFFFAOYSA-N n-(2,6-dimethyl-4-morpholin-4-ylphenyl)-2,3-dihydro-1-benzofuran-2-carboxamide Chemical compound C=1C(C)=C(NC(=O)C2OC3=CC=CC=C3C2)C(C)=CC=1N1CCOCC1 RQMWEJOBHGLLHJ-UHFFFAOYSA-N 0.000 claims description 2
• RZHYJMWCLWAHFW-UHFFFAOYSA-N n-(2,6-dimethyl-4-morpholin-4-ylphenyl)-2-(3,4-dimethylphenyl)acetamide Chemical compound C1=C(C)C(C)=CC=C1CC(=O)NC1=C(C)C=C(N2CCOCC2)C=C1C RZHYJMWCLWAHFW-UHFFFAOYSA-N 0.000 claims description 2
• BWTFEOVRRVXFIS-UHFFFAOYSA-N n-(2,6-dimethyl-4-morpholin-4-ylphenyl)-2-(3-fluorophenyl)acetamide Chemical compound CC1=CC(N2CCOCC2)=CC(C)=C1NC(=O)CC1=CC=CC(F)=C1 BWTFEOVRRVXFIS-UHFFFAOYSA-N 0.000 claims description 2
• BHJCRISXCWZQNL-UHFFFAOYSA-N n-(2,6-dimethyl-4-morpholin-4-ylphenyl)-2-(3-methylphenyl)acetamide Chemical compound CC1=CC=CC(CC(=O)NC=2C(=CC(=CC=2C)N2CCOCC2)C)=C1 BHJCRISXCWZQNL-UHFFFAOYSA-N 0.000 claims description 2
• FQXJKHBCIJGCQO-UHFFFAOYSA-N n-(2,6-dimethyl-4-morpholin-4-ylphenyl)-2-(4-fluorophenyl)acetamide Chemical compound CC1=CC(N2CCOCC2)=CC(C)=C1NC(=O)CC1=CC=C(F)C=C1 FQXJKHBCIJGCQO-UHFFFAOYSA-N 0.000 claims description 2
• LWXZAWFLFOVWCD-UHFFFAOYSA-N n-(2,6-dimethyl-4-morpholin-4-ylphenyl)-2-(4-methylphenyl)acetamide Chemical compound C1=CC(C)=CC=C1CC(=O)NC1=C(C)C=C(N2CCOCC2)C=C1C LWXZAWFLFOVWCD-UHFFFAOYSA-N 0.000 claims description 2
• WZSQCEVOMHBPFJ-UHFFFAOYSA-N n-(2,6-dimethyl-4-morpholin-4-ylphenyl)-2-[3-(trifluoromethyl)phenyl]acetamide Chemical compound CC1=CC(N2CCOCC2)=CC(C)=C1NC(=O)CC1=CC=CC(C(F)(F)F)=C1 WZSQCEVOMHBPFJ-UHFFFAOYSA-N 0.000 claims description 2
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• YZKODOMNCLLXIE-UHFFFAOYSA-N n-[1-[(6-chloro-1,3-benzodioxol-5-yl)methyl]-2,3-dihydroindol-5-yl]-3,3-dimethylbutanamide Chemical compound C1CC2=CC(NC(=O)CC(C)(C)C)=CC=C2N1CC(C(=C1)Cl)=CC2=C1OCO2 YZKODOMNCLLXIE-UHFFFAOYSA-N 0.000 claims description 2
• CHGPKEYXXUWPLC-UHFFFAOYSA-N n-[1-[(6-fluoro-4h-1,3-benzodioxin-8-yl)methyl]-2,3-dihydroindol-5-yl]-2-(4-fluorophenyl)acetamide Chemical compound C1=CC(F)=CC=C1CC(=O)NC1=CC=C(N(CC=2C=3OCOCC=3C=C(F)C=2)CC2)C2=C1 CHGPKEYXXUWPLC-UHFFFAOYSA-N 0.000 claims description 2
• VVFNUEKZVPMLRO-UHFFFAOYSA-N n-[1-[(6-fluoro-4h-1,3-benzodioxin-8-yl)methyl]-2,3-dihydroindol-5-yl]-3,3-dimethylbutanamide Chemical compound C1OCOC2=C1C=C(F)C=C2CN1C2=CC=C(NC(=O)CC(C)(C)C)C=C2CC1 VVFNUEKZVPMLRO-UHFFFAOYSA-N 0.000 claims description 2
• ZXAIVTUUGYJSJH-UHFFFAOYSA-N n-[1-[[1-(4-fluorophenyl)-5-methylpyrazol-4-yl]methyl]-2,3-dihydroindol-5-yl]-3,3-dimethylbutanamide Chemical compound CC1=C(CN2C3=CC=C(NC(=O)CC(C)(C)C)C=C3CC2)C=NN1C1=CC=C(F)C=C1 ZXAIVTUUGYJSJH-UHFFFAOYSA-N 0.000 claims description 2
• WVTBISXVGWDRJU-UHFFFAOYSA-N n-[1-[[2-chloro-5-(trifluoromethyl)phenyl]methyl]-2,3-dihydroindol-5-yl]-2-(4-fluorophenyl)acetamide Chemical compound C1=CC(F)=CC=C1CC(=O)NC1=CC=C(N(CC=2C(=CC=C(C=2)C(F)(F)F)Cl)CC2)C2=C1 WVTBISXVGWDRJU-UHFFFAOYSA-N 0.000 claims description 2
• UIPIUVZSTJLTJO-UHFFFAOYSA-N n-[1-[[2-chloro-5-(trifluoromethyl)phenyl]methyl]-2,3-dihydroindol-5-yl]-3,3-dimethylbutanamide Chemical compound C1CC2=CC(NC(=O)CC(C)(C)C)=CC=C2N1CC1=CC(C(F)(F)F)=CC=C1Cl UIPIUVZSTJLTJO-UHFFFAOYSA-N 0.000 claims description 2
• SYJPKVCEZJKYPM-UHFFFAOYSA-N n-[1-[[3-fluoro-4-(trifluoromethyl)phenyl]methyl]-2,3-dihydroindol-5-yl]-3,3-dimethylbutanamide Chemical compound C1CC2=CC(NC(=O)CC(C)(C)C)=CC=C2N1CC1=CC=C(C(F)(F)F)C(F)=C1 SYJPKVCEZJKYPM-UHFFFAOYSA-N 0.000 claims description 2
• CBTMVBYHAPYJDV-UHFFFAOYSA-N n-[1-[[5-(4-chlorophenoxy)-1,3-dimethylpyrazol-4-yl]methyl]-2,3-dihydroindol-5-yl]-2-(4-fluorophenyl)acetamide Chemical compound C1CC2=CC(NC(=O)CC=3C=CC(F)=CC=3)=CC=C2N1CC=1C(C)=NN(C)C=1OC1=CC=C(Cl)C=C1 CBTMVBYHAPYJDV-UHFFFAOYSA-N 0.000 claims description 2
• MCAYBEOKXFMNSH-UHFFFAOYSA-N n-[1-[[6-(4-chlorophenyl)sulfanylpyridin-3-yl]methyl]-2,3-dihydroindol-5-yl]-3,3-dimethylbutanamide Chemical compound C1CC2=CC(NC(=O)CC(C)(C)C)=CC=C2N1CC(C=N1)=CC=C1SC1=CC=C(Cl)C=C1 MCAYBEOKXFMNSH-UHFFFAOYSA-N 0.000 claims description 2
• VCHXEARYOTZKNN-UHFFFAOYSA-N n-[1-[[6-(4-cyanophenoxy)pyridin-3-yl]methyl]-2,3-dihydroindol-5-yl]-2-(4-fluorophenyl)acetamide Chemical compound C1=CC(F)=CC=C1CC(=O)NC1=CC=C(N(CC=2C=NC(OC=3C=CC(=CC=3)C#N)=CC=2)CC2)C2=C1 VCHXEARYOTZKNN-UHFFFAOYSA-N 0.000 claims description 2
• DLDPSEZMOLYRJJ-UHFFFAOYSA-N n-[1-[[6-(4-cyanophenoxy)pyridin-3-yl]methyl]-2,3-dihydroindol-5-yl]-3,3-dimethylbutanamide Chemical compound C1CC2=CC(NC(=O)CC(C)(C)C)=CC=C2N1CC(C=N1)=CC=C1OC1=CC=C(C#N)C=C1 DLDPSEZMOLYRJJ-UHFFFAOYSA-N 0.000 claims description 2
• JRMUSINHKOFJFV-UHFFFAOYSA-N n-[2,4-dimethyl-6-(2,2,5-trimethyl-3h-1-benzofuran-7-yl)phenyl]-2-(4-fluorophenyl)acetamide Chemical compound C=1C(C)=CC=2CC(C)(C)OC=2C=1C1=CC(C)=CC(C)=C1NC(=O)CC1=CC=C(F)C=C1 JRMUSINHKOFJFV-UHFFFAOYSA-N 0.000 claims description 2
• XAONIUOGFLUMOE-UHFFFAOYSA-N n-[2,4-dimethyl-6-(4-propan-2-ylphenyl)phenyl]-3,3-dimethylbutanamide Chemical compound C1=CC(C(C)C)=CC=C1C1=CC(C)=CC(C)=C1NC(=O)CC(C)(C)C XAONIUOGFLUMOE-UHFFFAOYSA-N 0.000 claims description 2
• DNUHYUKYPLADFM-UHFFFAOYSA-N n-[2,4-dimethyl-6-[3-(trifluoromethoxy)phenyl]phenyl]-2-(4-fluorophenyl)acetamide Chemical compound C=1C=CC(OC(F)(F)F)=CC=1C1=CC(C)=CC(C)=C1NC(=O)CC1=CC=C(F)C=C1 DNUHYUKYPLADFM-UHFFFAOYSA-N 0.000 claims description 2
• DAVKBZXKNMPEHG-UHFFFAOYSA-N n-[2,6-dimethyl-4-[[4-(trifluoromethyl)phenyl]methylamino]phenyl]acetamide Chemical compound C1=C(C)C(NC(=O)C)=C(C)C=C1NCC1=CC=C(C(F)(F)F)C=C1 DAVKBZXKNMPEHG-UHFFFAOYSA-N 0.000 claims description 2
• BQIIVIXQLUJZJJ-UHFFFAOYSA-N n-[2,6-dimethyl-4-[[6-(trifluoromethyl)pyridin-3-yl]methylamino]phenyl]-3,3-dimethylbutanamide Chemical compound CC1=C(NC(=O)CC(C)(C)C)C(C)=CC(NCC=2C=NC(=CC=2)C(F)(F)F)=C1 BQIIVIXQLUJZJJ-UHFFFAOYSA-N 0.000 claims description 2
• NPKGBLZCKDGMPK-UHFFFAOYSA-N n-[2,6-dimethyl-4-[methyl-[[4-(trifluoromethyl)phenyl]methyl]amino]phenyl]acetamide Chemical compound C=1C(C)=C(NC(C)=O)C(C)=CC=1N(C)CC1=CC=C(C(F)(F)F)C=C1 NPKGBLZCKDGMPK-UHFFFAOYSA-N 0.000 claims description 2
• ADEYHVVPEMWXKK-UHFFFAOYSA-N n-[2-(2,3-dihydro-1,4-benzodioxin-6-yl)-4,6-dimethylphenyl]-2-(4-fluorophenyl)acetamide Chemical compound C=1C=C2OCCOC2=CC=1C1=CC(C)=CC(C)=C1NC(=O)CC1=CC=C(F)C=C1 ADEYHVVPEMWXKK-UHFFFAOYSA-N 0.000 claims description 2
• HYADKSBTWYHMRC-UHFFFAOYSA-N n-[2-(3-acetamidophenyl)-4,6-dimethylphenyl]-2-(4-fluorophenyl)acetamide Chemical compound CC(=O)NC1=CC=CC(C=2C(=C(C)C=C(C)C=2)NC(=O)CC=2C=CC(F)=CC=2)=C1 HYADKSBTWYHMRC-UHFFFAOYSA-N 0.000 claims description 2
• XYJIVBJRAKFODH-UHFFFAOYSA-N n-[2-(3-aminophenyl)-4,6-dimethylphenyl]-2-(4-fluorophenyl)acetamide Chemical compound C=1C=CC(N)=CC=1C1=CC(C)=CC(C)=C1NC(=O)CC1=CC=C(F)C=C1 XYJIVBJRAKFODH-UHFFFAOYSA-N 0.000 claims description 2
• SXSIMUQLWHAEGS-UHFFFAOYSA-N n-[2-(3-cyanophenyl)-4,6-dimethylphenyl]-2-(4-fluorophenyl)acetamide Chemical compound C=1C=CC(C#N)=CC=1C1=CC(C)=CC(C)=C1NC(=O)CC1=CC=C(F)C=C1 SXSIMUQLWHAEGS-UHFFFAOYSA-N 0.000 claims description 2
• KECGJWZRAYXEMQ-UHFFFAOYSA-N n-[2-(4-ethenylphenyl)-4,6-dimethylphenyl]-2-(4-fluorophenyl)acetamide Chemical compound C=1C=C(C=C)C=CC=1C1=CC(C)=CC(C)=C1NC(=O)CC1=CC=C(F)C=C1 KECGJWZRAYXEMQ-UHFFFAOYSA-N 0.000 claims description 2
• LXGHGBFMMWWRPL-UHFFFAOYSA-N n-[2-[3,5-bis(trifluoromethyl)phenyl]-4,6-dimethylphenyl]-2-(4-fluorophenyl)acetamide Chemical compound C=1C(C(F)(F)F)=CC(C(F)(F)F)=CC=1C1=CC(C)=CC(C)=C1NC(=O)CC1=CC=C(F)C=C1 LXGHGBFMMWWRPL-UHFFFAOYSA-N 0.000 claims description 2
• ISMXZIBRJLAXBF-UHFFFAOYSA-N n-[2-[4-(dimethylamino)phenyl]-4,6-dimethylphenyl]-2-(4-fluorophenyl)acetamide Chemical compound C1=CC(N(C)C)=CC=C1C1=CC(C)=CC(C)=C1NC(=O)CC1=CC=C(F)C=C1 ISMXZIBRJLAXBF-UHFFFAOYSA-N 0.000 claims description 2
• ILXWQQLVKRBUAO-UHFFFAOYSA-N n-[2-amino-4-[(3-fluoroanilino)methyl]phenyl]-2,2-dimethylpropanamide Chemical compound C1=C(N)C(NC(=O)C(C)(C)C)=CC=C1CNC1=CC=CC(F)=C1 ILXWQQLVKRBUAO-UHFFFAOYSA-N 0.000 claims description 2
• GOXFPLZEUOSYNS-UHFFFAOYSA-N n-[2-amino-4-[(5-chlorothiophen-2-yl)methylamino]phenyl]-2-(4-fluorophenyl)acetamide Chemical compound C=1C=C(NC(=O)CC=2C=CC(F)=CC=2)C(N)=CC=1NCC1=CC=C(Cl)S1 GOXFPLZEUOSYNS-UHFFFAOYSA-N 0.000 claims description 2
• SNQCBOUYAWFQCM-UHFFFAOYSA-N n-[2-amino-4-[(5-chlorothiophen-2-yl)methylamino]phenyl]-3,3-dimethylbutanamide Chemical compound C1=C(N)C(NC(=O)CC(C)(C)C)=CC=C1NCC1=CC=C(Cl)S1 SNQCBOUYAWFQCM-UHFFFAOYSA-N 0.000 claims description 2
• IOILGKDZUBZKAY-UHFFFAOYSA-N n-[2-bromo-4-[(5-chlorothiophen-2-yl)methylamino]-6-(trifluoromethyl)phenyl]-3-cyclohexylpropanamide Chemical compound C=1C(Br)=C(NC(=O)CCC2CCCCC2)C(C(F)(F)F)=CC=1NCC1=CC=C(Cl)S1 IOILGKDZUBZKAY-UHFFFAOYSA-N 0.000 claims description 2
• JXVMTGLEBIWOHI-UHFFFAOYSA-N n-[2-bromo-4-morpholin-4-yl-6-(trifluoromethyl)phenyl]-2-(3-fluorophenyl)acetamide Chemical compound FC1=CC=CC(CC(=O)NC=2C(=CC(=CC=2Br)N2CCOCC2)C(F)(F)F)=C1 JXVMTGLEBIWOHI-UHFFFAOYSA-N 0.000 claims description 2
• VEZLUWKLAGYAPU-UHFFFAOYSA-N n-[2-bromo-4-morpholin-4-yl-6-(trifluoromethyl)phenyl]-2-cyclopentylacetamide Chemical compound FC(F)(F)C1=CC(N2CCOCC2)=CC(Br)=C1NC(=O)CC1CCCC1 VEZLUWKLAGYAPU-UHFFFAOYSA-N 0.000 claims description 2
• ZAWSOIRSBNEJNI-UHFFFAOYSA-N n-[2-bromo-4-morpholin-4-yl-6-(trifluoromethyl)phenyl]-3-cyclohexylpropanamide Chemical compound FC(F)(F)C1=CC(N2CCOCC2)=CC(Br)=C1NC(=O)CCC1CCCCC1 ZAWSOIRSBNEJNI-UHFFFAOYSA-N 0.000 claims description 2
• LNEODKACMQDIAF-UHFFFAOYSA-N n-[2-bromo-4-morpholin-4-yl-6-(trifluoromethyl)phenyl]-3-cyclopentylpropanamide Chemical compound FC(F)(F)C1=CC(N2CCOCC2)=CC(Br)=C1NC(=O)CCC1CCCC1 LNEODKACMQDIAF-UHFFFAOYSA-N 0.000 claims description 2
• AOSDPVXNYCUYSW-UHFFFAOYSA-N n-[2-chloro-4-[(3,4-dichloroanilino)methyl]phenyl]butanamide Chemical compound C1=C(Cl)C(NC(=O)CCC)=CC=C1CNC1=CC=C(Cl)C(Cl)=C1 AOSDPVXNYCUYSW-UHFFFAOYSA-N 0.000 claims description 2
• HSXJTDIWKDHOPI-UHFFFAOYSA-N n-[2-chloro-4-[(3-fluoroanilino)methyl]phenyl]butanamide Chemical compound C1=C(Cl)C(NC(=O)CCC)=CC=C1CNC1=CC=CC(F)=C1 HSXJTDIWKDHOPI-UHFFFAOYSA-N 0.000 claims description 2
• DBLOEDMPCORMST-UHFFFAOYSA-N n-[2-chloro-4-[(4-chloro-3-fluoroanilino)methyl]phenyl]butanamide Chemical compound C1=C(Cl)C(NC(=O)CCC)=CC=C1CNC1=CC=C(Cl)C(F)=C1 DBLOEDMPCORMST-UHFFFAOYSA-N 0.000 claims description 2
• SHXIJKYXFWJGDT-UHFFFAOYSA-N n-[2-chloro-4-[(4-chloroanilino)methyl]phenyl]butanamide Chemical compound C1=C(Cl)C(NC(=O)CCC)=CC=C1CNC1=CC=C(Cl)C=C1 SHXIJKYXFWJGDT-UHFFFAOYSA-N 0.000 claims description 2
• HRQLXROTHVOVME-UHFFFAOYSA-N n-[2-chloro-4-[(4-fluoroanilino)methyl]phenyl]butanamide Chemical compound C1=C(Cl)C(NC(=O)CCC)=CC=C1CNC1=CC=C(F)C=C1 HRQLXROTHVOVME-UHFFFAOYSA-N 0.000 claims description 2
• DSPRNVSQYVZCFI-UHFFFAOYSA-N n-[2-chloro-4-[(5-chlorothiophen-2-yl)methyl-methylamino]phenyl]-2,2,2-trifluoroacetamide Chemical compound C=1C=C(NC(=O)C(F)(F)F)C(Cl)=CC=1N(C)CC1=CC=C(Cl)S1 DSPRNVSQYVZCFI-UHFFFAOYSA-N 0.000 claims description 2
• RJIRJOHWLZOJNX-UHFFFAOYSA-N n-[2-chloro-4-[(5-chlorothiophen-2-yl)methyl-methylamino]phenyl]-2-(3-methoxyphenyl)acetamide Chemical compound COC1=CC=CC(CC(=O)NC=2C(=CC(=CC=2)N(C)CC=2SC(Cl)=CC=2)Cl)=C1 RJIRJOHWLZOJNX-UHFFFAOYSA-N 0.000 claims description 2
• KNCNOLISTQSDIB-UHFFFAOYSA-N n-[2-chloro-4-[(5-chlorothiophen-2-yl)methyl-methylamino]phenyl]-2-(4-chlorophenyl)propanamide Chemical compound C=1C=C(Cl)C=CC=1C(C)C(=O)NC(C(=C1)Cl)=CC=C1N(C)CC1=CC=C(Cl)S1 KNCNOLISTQSDIB-UHFFFAOYSA-N 0.000 claims description 2
• QQMOLIHEOHSEJW-UHFFFAOYSA-N n-[2-chloro-4-[(5-chlorothiophen-2-yl)methyl-methylamino]phenyl]-2-(4-fluorophenyl)acetamide Chemical compound C=1C=C(NC(=O)CC=2C=CC(F)=CC=2)C(Cl)=CC=1N(C)CC1=CC=C(Cl)S1 QQMOLIHEOHSEJW-UHFFFAOYSA-N 0.000 claims description 2
• NHGMMGIROLDGFV-UHFFFAOYSA-N n-[2-chloro-4-[(5-chlorothiophen-2-yl)methyl-methylamino]phenyl]-2-(4-methoxyphenyl)acetamide Chemical compound C1=CC(OC)=CC=C1CC(=O)NC1=CC=C(N(C)CC=2SC(Cl)=CC=2)C=C1Cl NHGMMGIROLDGFV-UHFFFAOYSA-N 0.000 claims description 2
• HJUMLZPJCRCVMP-UHFFFAOYSA-N n-[2-chloro-4-[(5-chlorothiophen-2-yl)methyl-methylamino]phenyl]-2-thiophen-2-ylacetamide Chemical compound C=1C=C(NC(=O)CC=2SC=CC=2)C(Cl)=CC=1N(C)CC1=CC=C(Cl)S1 HJUMLZPJCRCVMP-UHFFFAOYSA-N 0.000 claims description 2
• QOJZWSIRHHMUND-UHFFFAOYSA-N n-[2-chloro-4-[(5-chlorothiophen-2-yl)methyl-methylamino]phenyl]-3-cyclohexylpropanamide Chemical compound C=1C=C(NC(=O)CCC2CCCCC2)C(Cl)=CC=1N(C)CC1=CC=C(Cl)S1 QOJZWSIRHHMUND-UHFFFAOYSA-N 0.000 claims description 2
• XEQYECZAIUQLSF-UHFFFAOYSA-N n-[2-chloro-4-[(5-chlorothiophen-2-yl)methyl-methylamino]phenyl]-3-phenylpropanamide Chemical compound C=1C=C(NC(=O)CCC=2C=CC=CC=2)C(Cl)=CC=1N(C)CC1=CC=C(Cl)S1 XEQYECZAIUQLSF-UHFFFAOYSA-N 0.000 claims description 2
• ZXIJIODJNIISBC-UHFFFAOYSA-N n-[2-chloro-4-[(5-chlorothiophen-2-yl)methyl-methylamino]phenyl]butanamide Chemical compound C1=C(Cl)C(NC(=O)CCC)=CC=C1N(C)CC1=CC=C(Cl)S1 ZXIJIODJNIISBC-UHFFFAOYSA-N 0.000 claims description 2
• ICTXQIPJUUCOJP-UHFFFAOYSA-N n-[2-chloro-4-[(5-chlorothiophen-2-yl)methyl-methylamino]phenyl]cyclobutanecarboxamide Chemical compound C=1C=C(NC(=O)C2CCC2)C(Cl)=CC=1N(C)CC1=CC=C(Cl)S1 ICTXQIPJUUCOJP-UHFFFAOYSA-N 0.000 claims description 2
• IEWASZTYXBKWSP-UHFFFAOYSA-N n-[2-chloro-4-[(5-chlorothiophen-2-yl)methyl-methylamino]phenyl]cyclohexanecarboxamide Chemical compound C=1C=C(NC(=O)C2CCCCC2)C(Cl)=CC=1N(C)CC1=CC=C(Cl)S1 IEWASZTYXBKWSP-UHFFFAOYSA-N 0.000 claims description 2
• GTFNEWRWVYJMGD-UHFFFAOYSA-N n-[2-chloro-4-[(5-chlorothiophen-2-yl)methyl-methylamino]phenyl]cyclopentanecarboxamide Chemical compound C=1C=C(NC(=O)C2CCCC2)C(Cl)=CC=1N(C)CC1=CC=C(Cl)S1 GTFNEWRWVYJMGD-UHFFFAOYSA-N 0.000 claims description 2
• QVVCRTNUUALZJM-UHFFFAOYSA-N n-[2-chloro-4-[(5-chlorothiophen-2-yl)methyl-methylamino]phenyl]cyclopropanecarboxamide Chemical compound C=1C=C(NC(=O)C2CC2)C(Cl)=CC=1N(C)CC1=CC=C(Cl)S1 QVVCRTNUUALZJM-UHFFFAOYSA-N 0.000 claims description 2
• KTVYZDPJAAPEAD-UHFFFAOYSA-N n-[2-chloro-4-[(5-chlorothiophen-2-yl)methyl-methylamino]phenyl]pentanamide Chemical compound C1=C(Cl)C(NC(=O)CCCC)=CC=C1N(C)CC1=CC=C(Cl)S1 KTVYZDPJAAPEAD-UHFFFAOYSA-N 0.000 claims description 2
• UWLQXWWVEUDTNY-UHFFFAOYSA-N n-[2-chloro-4-[(5-chlorothiophen-2-yl)methylamino]phenyl]-2,2,2-trifluoroacetamide Chemical compound C1=C(Cl)C(NC(=O)C(F)(F)F)=CC=C1NCC1=CC=C(Cl)S1 UWLQXWWVEUDTNY-UHFFFAOYSA-N 0.000 claims description 2
• YFDSOWUYPDFCDA-UHFFFAOYSA-N n-[2-chloro-4-[(5-chlorothiophen-2-yl)methylamino]phenyl]-2,2-dimethylpropanamide Chemical compound C1=C(Cl)C(NC(=O)C(C)(C)C)=CC=C1NCC1=CC=C(Cl)S1 YFDSOWUYPDFCDA-UHFFFAOYSA-N 0.000 claims description 2
• LDARJHDVQXQBCR-UHFFFAOYSA-N n-[2-chloro-4-[(5-chlorothiophen-2-yl)methylamino]phenyl]-2,3-dihydro-1,4-benzodioxine-6-carboxamide Chemical compound S1C(Cl)=CC=C1CNC(C=C1Cl)=CC=C1NC(=O)C1=CC=C(OCCO2)C2=C1 LDARJHDVQXQBCR-UHFFFAOYSA-N 0.000 claims description 2
• BAZNEVZTWJPXMM-UHFFFAOYSA-N n-[2-chloro-4-[(5-chlorothiophen-2-yl)methylamino]phenyl]-2,3-dihydro-1-benzofuran-5-carboxamide Chemical compound S1C(Cl)=CC=C1CNC(C=C1Cl)=CC=C1NC(=O)C1=CC=C(OCC2)C2=C1 BAZNEVZTWJPXMM-UHFFFAOYSA-N 0.000 claims description 2
• GZPCNLCZYOCMLW-UHFFFAOYSA-N n-[2-chloro-4-[(5-chlorothiophen-2-yl)methylamino]phenyl]-2-(3-methoxyphenyl)acetamide Chemical compound COC1=CC=CC(CC(=O)NC=2C(=CC(NCC=3SC(Cl)=CC=3)=CC=2)Cl)=C1 GZPCNLCZYOCMLW-UHFFFAOYSA-N 0.000 claims description 2
• QPWADJHNRLEIQB-UHFFFAOYSA-N n-[2-chloro-4-[(5-chlorothiophen-2-yl)methylamino]phenyl]-2-(4-chlorophenyl)acetamide Chemical compound S1C(Cl)=CC=C1CNC(C=C1Cl)=CC=C1NC(=O)CC1=CC=C(Cl)C=C1 QPWADJHNRLEIQB-UHFFFAOYSA-N 0.000 claims description 2
• VTUWOQKVXMNJRR-UHFFFAOYSA-N n-[2-chloro-4-[(5-chlorothiophen-2-yl)methylamino]phenyl]-2-(4-fluorophenyl)acetamide Chemical compound C1=CC(F)=CC=C1CC(=O)NC(C(=C1)Cl)=CC=C1NCC1=CC=C(Cl)S1 VTUWOQKVXMNJRR-UHFFFAOYSA-N 0.000 claims description 2
• BLZIGMLBKKOBNU-UHFFFAOYSA-N n-[2-chloro-4-[(5-chlorothiophen-2-yl)methylamino]phenyl]-2-(4-methoxyphenyl)acetamide Chemical compound C1=CC(OC)=CC=C1CC(=O)NC(C(=C1)Cl)=CC=C1NCC1=CC=C(Cl)S1 BLZIGMLBKKOBNU-UHFFFAOYSA-N 0.000 claims description 2
• BCGYFDWDTFWDIR-UHFFFAOYSA-N n-[2-chloro-4-[(5-chlorothiophen-2-yl)methylamino]phenyl]-2-phenoxyacetamide Chemical compound S1C(Cl)=CC=C1CNC(C=C1Cl)=CC=C1NC(=O)COC1=CC=CC=C1 BCGYFDWDTFWDIR-UHFFFAOYSA-N 0.000 claims description 2
• AEOSUEWFLMVAFB-UHFFFAOYSA-N n-[2-chloro-4-[(5-chlorothiophen-2-yl)methylamino]phenyl]-2-phenylacetamide Chemical compound S1C(Cl)=CC=C1CNC(C=C1Cl)=CC=C1NC(=O)CC1=CC=CC=C1 AEOSUEWFLMVAFB-UHFFFAOYSA-N 0.000 claims description 2
• OOFJORNTRHEEFY-UHFFFAOYSA-N n-[2-chloro-4-[(5-chlorothiophen-2-yl)methylamino]phenyl]-2-thiophen-2-ylacetamide Chemical compound S1C(Cl)=CC=C1CNC(C=C1Cl)=CC=C1NC(=O)CC1=CC=CS1 OOFJORNTRHEEFY-UHFFFAOYSA-N 0.000 claims description 2
• GBUJVXQGXXEWHN-UHFFFAOYSA-N n-[2-chloro-4-[(5-chlorothiophen-2-yl)methylamino]phenyl]-3,3-dimethylbutanamide Chemical compound C1=C(Cl)C(NC(=O)CC(C)(C)C)=CC=C1NCC1=CC=C(Cl)S1 GBUJVXQGXXEWHN-UHFFFAOYSA-N 0.000 claims description 2
• UHHGGSIKLWJNOT-UHFFFAOYSA-N n-[2-chloro-4-[(5-chlorothiophen-2-yl)methylamino]phenyl]-3-cyclohexylpropanamide Chemical compound S1C(Cl)=CC=C1CNC(C=C1Cl)=CC=C1NC(=O)CCC1CCCCC1 UHHGGSIKLWJNOT-UHFFFAOYSA-N 0.000 claims description 2
• PDZFLRVABUEWSZ-UHFFFAOYSA-N n-[2-chloro-4-[(5-chlorothiophen-2-yl)methylamino]phenyl]butanamide Chemical compound C1=C(Cl)C(NC(=O)CCC)=CC=C1NCC1=CC=C(Cl)S1 PDZFLRVABUEWSZ-UHFFFAOYSA-N 0.000 claims description 2
• WMRAUBJGYGJYFV-UHFFFAOYSA-N n-[2-chloro-4-[(5-chlorothiophen-2-yl)methylamino]phenyl]cyclobutanecarboxamide Chemical compound S1C(Cl)=CC=C1CNC(C=C1Cl)=CC=C1NC(=O)C1CCC1 WMRAUBJGYGJYFV-UHFFFAOYSA-N 0.000 claims description 2
• PABXVNVCLLFEJC-UHFFFAOYSA-N n-[2-chloro-4-[(5-chlorothiophen-2-yl)methylamino]phenyl]cyclohexanecarboxamide Chemical compound S1C(Cl)=CC=C1CNC(C=C1Cl)=CC=C1NC(=O)C1CCCCC1 PABXVNVCLLFEJC-UHFFFAOYSA-N 0.000 claims description 2
• AOFLYATWZBSEOS-UHFFFAOYSA-N n-[2-chloro-4-[(5-chlorothiophen-2-yl)methylamino]phenyl]cyclopentanecarboxamide Chemical compound S1C(Cl)=CC=C1CNC(C=C1Cl)=CC=C1NC(=O)C1CCCC1 AOFLYATWZBSEOS-UHFFFAOYSA-N 0.000 claims description 2
• FVRNPBWTHTZVBH-UHFFFAOYSA-N n-[2-chloro-4-[(5-chlorothiophen-2-yl)methylamino]phenyl]cyclopropanecarboxamide Chemical compound S1C(Cl)=CC=C1CNC(C=C1Cl)=CC=C1NC(=O)C1CC1 FVRNPBWTHTZVBH-UHFFFAOYSA-N 0.000 claims description 2
• HMSYDJFUVJCDSK-UHFFFAOYSA-N n-[2-chloro-4-[(5-chlorothiophen-2-yl)methylamino]phenyl]pentanamide Chemical compound C1=C(Cl)C(NC(=O)CCCC)=CC=C1NCC1=CC=C(Cl)S1 HMSYDJFUVJCDSK-UHFFFAOYSA-N 0.000 claims description 2
• SIONWVZOLMLQGG-UHFFFAOYSA-N n-[2-chloro-4-[[4-(trifluoromethyl)anilino]methyl]phenyl]butanamide Chemical compound C1=C(Cl)C(NC(=O)CCC)=CC=C1CNC1=CC=C(C(F)(F)F)C=C1 SIONWVZOLMLQGG-UHFFFAOYSA-N 0.000 claims description 2
• XSAPBUXDUGPCDB-UHFFFAOYSA-N n-[2-chloro-4-morpholin-4-yl-6-(trifluoromethyl)phenyl]-2-(3-fluorophenyl)acetamide Chemical compound FC1=CC=CC(CC(=O)NC=2C(=CC(=CC=2Cl)N2CCOCC2)C(F)(F)F)=C1 XSAPBUXDUGPCDB-UHFFFAOYSA-N 0.000 claims description 2
• VRZOMCHSAMLLPJ-UHFFFAOYSA-N n-[2-chloro-4-morpholin-4-yl-6-(trifluoromethyl)phenyl]-2-cyclopentylacetamide Chemical compound FC(F)(F)C1=CC(N2CCOCC2)=CC(Cl)=C1NC(=O)CC1CCCC1 VRZOMCHSAMLLPJ-UHFFFAOYSA-N 0.000 claims description 2
• SRPRNABRIZJJKK-UHFFFAOYSA-N n-[2-chloro-6-methyl-4-[[6-(trifluoromethyl)pyridin-3-yl]methylamino]phenyl]-2-(3-fluorophenyl)acetamide Chemical compound C=1C(Cl)=C(NC(=O)CC=2C=C(F)C=CC=2)C(C)=CC=1NCC1=CC=C(C(F)(F)F)N=C1 SRPRNABRIZJJKK-UHFFFAOYSA-N 0.000 claims description 2
• VNXLQHITRXDULI-UHFFFAOYSA-N n-[2-fluoro-4-[(3-fluoroanilino)methyl]phenyl]butanamide Chemical compound C1=C(F)C(NC(=O)CCC)=CC=C1CNC1=CC=CC(F)=C1 VNXLQHITRXDULI-UHFFFAOYSA-N 0.000 claims description 2
• YIJKAGUJZZPFTO-UHFFFAOYSA-N n-[2-fluoro-4-[[4-(trifluoromethyl)anilino]methyl]phenyl]butanamide Chemical compound C1=C(F)C(NC(=O)CCC)=CC=C1CNC1=CC=C(C(F)(F)F)C=C1 YIJKAGUJZZPFTO-UHFFFAOYSA-N 0.000 claims description 2
• GEUIQJWDQZWGRE-UHFFFAOYSA-N n-[2-methoxy-4-[(4-propan-2-ylphenyl)methylamino]phenyl]butanamide Chemical compound C1=C(OC)C(NC(=O)CCC)=CC=C1NCC1=CC=C(C(C)C)C=C1 GEUIQJWDQZWGRE-UHFFFAOYSA-N 0.000 claims description 2
• TUXZGMKFRZJZSM-UHFFFAOYSA-N n-[2-methoxy-4-[[4-(trifluoromethyl)phenyl]methylamino]phenyl]butanamide Chemical compound C1=C(OC)C(NC(=O)CCC)=CC=C1NCC1=CC=C(C(F)(F)F)C=C1 TUXZGMKFRZJZSM-UHFFFAOYSA-N 0.000 claims description 2
• JSYCSVLZYSFSBB-UHFFFAOYSA-N n-[2-methyl-4-[[4-(trifluoromethyl)phenyl]methylamino]phenyl]-2-morpholin-4-ylacetamide Chemical compound C=1C=C(NC(=O)CN2CCOCC2)C(C)=CC=1NCC1=CC=C(C(F)(F)F)C=C1 JSYCSVLZYSFSBB-UHFFFAOYSA-N 0.000 claims description 2
• NDZPOHAYEUWMTA-UHFFFAOYSA-N n-[2-methyl-4-[[4-(trifluoromethyl)phenyl]methylamino]phenyl]-2-piperidin-1-ylacetamide Chemical compound C=1C=C(NC(=O)CN2CCCCC2)C(C)=CC=1NCC1=CC=C(C(F)(F)F)C=C1 NDZPOHAYEUWMTA-UHFFFAOYSA-N 0.000 claims description 2
• AQDSFYZMSFHLTN-UHFFFAOYSA-N n-[2-methyl-4-[[4-(trifluoromethyl)phenyl]methylamino]phenyl]-2-pyrrolidin-1-ylacetamide Chemical compound C=1C=C(NC(=O)CN2CCCC2)C(C)=CC=1NCC1=CC=C(C(F)(F)F)C=C1 AQDSFYZMSFHLTN-UHFFFAOYSA-N 0.000 claims description 2
• WGJUXKMIFGCNDM-UHFFFAOYSA-N n-[2-methyl-4-[[4-(trifluoromethyl)phenyl]methylamino]phenyl]butanamide Chemical compound C1=C(C)C(NC(=O)CCC)=CC=C1NCC1=CC=C(C(F)(F)F)C=C1 WGJUXKMIFGCNDM-UHFFFAOYSA-N 0.000 claims description 2
• YYXJEXZKPIYXQH-UHFFFAOYSA-N n-[4-(azepan-1-yl)-2,6-dimethylphenyl]-2-cyclopentylacetamide Chemical compound CC1=CC(N2CCCCCC2)=CC(C)=C1NC(=O)CC1CCCC1 YYXJEXZKPIYXQH-UHFFFAOYSA-N 0.000 claims description 2
• NHXHKDUACVRVPF-UHFFFAOYSA-N n-[4-[(3,4-dichloroanilino)methyl]-2-fluorophenyl]butanamide Chemical compound C1=C(F)C(NC(=O)CCC)=CC=C1CNC1=CC=C(Cl)C(Cl)=C1 NHXHKDUACVRVPF-UHFFFAOYSA-N 0.000 claims description 2
• IIHYQCLDAORSCI-UHFFFAOYSA-N n-[4-[(3,4-dichloroanilino)methyl]-2-methylphenyl]butanamide Chemical compound C1=C(C)C(NC(=O)CCC)=CC=C1CNC1=CC=C(Cl)C(Cl)=C1 IIHYQCLDAORSCI-UHFFFAOYSA-N 0.000 claims description 2
• USVPVZBUNHDWDV-UHFFFAOYSA-N n-[4-[(3,4-dichloroanilino)methyl]phenyl]butanamide Chemical compound C1=CC(NC(=O)CCC)=CC=C1CNC1=CC=C(Cl)C(Cl)=C1 USVPVZBUNHDWDV-UHFFFAOYSA-N 0.000 claims description 2
• SGOJPZRZKYMFBN-UHFFFAOYSA-N n-[4-[(3-chloroanilino)methyl]-2,6-dimethylphenyl]-2-cyclopentylacetamide Chemical compound C=1C(C)=C(NC(=O)CC2CCCC2)C(C)=CC=1CNC1=CC=CC(Cl)=C1 SGOJPZRZKYMFBN-UHFFFAOYSA-N 0.000 claims description 2
• AJURBOPYTAEEME-UHFFFAOYSA-N n-[4-[(3-fluoroanilino)methyl]-2-methylphenyl]butanamide Chemical compound C1=C(C)C(NC(=O)CCC)=CC=C1CNC1=CC=CC(F)=C1 AJURBOPYTAEEME-UHFFFAOYSA-N 0.000 claims description 2
• ANCSKQQFJNCGFC-UHFFFAOYSA-N n-[4-[(4-chloro-3-fluoroanilino)methyl]-2-fluorophenyl]butanamide Chemical compound C1=C(F)C(NC(=O)CCC)=CC=C1CNC1=CC=C(Cl)C(F)=C1 ANCSKQQFJNCGFC-UHFFFAOYSA-N 0.000 claims description 2
• KEJHLHSTFNWOIR-UHFFFAOYSA-N n-[4-[(4-chloro-3-fluoroanilino)methyl]-2-methylphenyl]butanamide Chemical compound C1=C(C)C(NC(=O)CCC)=CC=C1CNC1=CC=C(Cl)C(F)=C1 KEJHLHSTFNWOIR-UHFFFAOYSA-N 0.000 claims description 2
• CKRMGYYYPLOCHM-UHFFFAOYSA-N n-[4-[(4-chloro-3-fluoroanilino)methyl]phenyl]butanamide Chemical compound C1=CC(NC(=O)CCC)=CC=C1CNC1=CC=C(Cl)C(F)=C1 CKRMGYYYPLOCHM-UHFFFAOYSA-N 0.000 claims description 2
• ZHOSOIRHYDABAJ-UHFFFAOYSA-N n-[4-[(4-chloroanilino)methyl]-2,6-dimethylphenyl]-2-(4-chlorophenyl)acetamide Chemical compound C=1C(C)=C(NC(=O)CC=2C=CC(Cl)=CC=2)C(C)=CC=1CNC1=CC=C(Cl)C=C1 ZHOSOIRHYDABAJ-UHFFFAOYSA-N 0.000 claims description 2
• SWJZWKSJUDGALQ-UHFFFAOYSA-N n-[4-[(4-chloroanilino)methyl]-2,6-dimethylphenyl]-2-cyclopentylacetamide Chemical compound C=1C(C)=C(NC(=O)CC2CCCC2)C(C)=CC=1CNC1=CC=C(Cl)C=C1 SWJZWKSJUDGALQ-UHFFFAOYSA-N 0.000 claims description 2
• HFOBLYQFMYXPKI-UHFFFAOYSA-N n-[4-[(4-chloroanilino)methyl]-2,6-dimethylphenyl]pentanamide Chemical compound C1=C(C)C(NC(=O)CCCC)=C(C)C=C1CNC1=CC=C(Cl)C=C1 HFOBLYQFMYXPKI-UHFFFAOYSA-N 0.000 claims description 2
• YNWPLUKYJAPYJQ-UHFFFAOYSA-N n-[4-[(4-chloroanilino)methyl]-2-fluorophenyl]butanamide Chemical compound C1=C(F)C(NC(=O)CCC)=CC=C1CNC1=CC=C(Cl)C=C1 YNWPLUKYJAPYJQ-UHFFFAOYSA-N 0.000 claims description 2
• XFZWRYINWCHARH-UHFFFAOYSA-N n-[4-[(4-chloroanilino)methyl]-2-methylphenyl]butanamide Chemical compound C1=C(C)C(NC(=O)CCC)=CC=C1CNC1=CC=C(Cl)C=C1 XFZWRYINWCHARH-UHFFFAOYSA-N 0.000 claims description 2
• SESQTSCDOREBKJ-UHFFFAOYSA-N n-[4-[(4-chloroanilino)methyl]phenyl]butanamide Chemical compound C1=CC(NC(=O)CCC)=CC=C1CNC1=CC=C(Cl)C=C1 SESQTSCDOREBKJ-UHFFFAOYSA-N 0.000 claims description 2
• IMMNNWSVPCTHKC-UHFFFAOYSA-N n-[4-[(4-fluoroanilino)methyl]-2-methylphenyl]butanamide Chemical compound C1=C(C)C(NC(=O)CCC)=CC=C1CNC1=CC=C(F)C=C1 IMMNNWSVPCTHKC-UHFFFAOYSA-N 0.000 claims description 2
• LJRXFNXMIQEJIO-UHFFFAOYSA-N n-[4-[(4-tert-butylphenyl)methylamino]-2-methoxyphenyl]butanamide Chemical compound C1=C(OC)C(NC(=O)CCC)=CC=C1NCC1=CC=C(C(C)(C)C)C=C1 LJRXFNXMIQEJIO-UHFFFAOYSA-N 0.000 claims description 2
• QXLDJYKVHQGGIE-UHFFFAOYSA-N n-[4-[(5-bromothiophen-2-yl)methylamino]-2-methoxyphenyl]butanamide Chemical compound C1=C(OC)C(NC(=O)CCC)=CC=C1NCC1=CC=C(Br)S1 QXLDJYKVHQGGIE-UHFFFAOYSA-N 0.000 claims description 2
• PUWKCSUQTQBIRA-UHFFFAOYSA-N n-[4-[(5-chlorothiophen-2-yl)methyl-methylamino]-2-methylphenyl]-2,2-dimethylpropanamide Chemical compound C=1C=C(NC(=O)C(C)(C)C)C(C)=CC=1N(C)CC1=CC=C(Cl)S1 PUWKCSUQTQBIRA-UHFFFAOYSA-N 0.000 claims description 2
• BYMZSQYOOFBETO-UHFFFAOYSA-N n-[4-[(5-chlorothiophen-2-yl)methyl-methylamino]-2-methylphenyl]-2-(3-methoxyphenyl)acetamide Chemical compound COC1=CC=CC(CC(=O)NC=2C(=CC(=CC=2)N(C)CC=2SC(Cl)=CC=2)C)=C1 BYMZSQYOOFBETO-UHFFFAOYSA-N 0.000 claims description 2
• XFEGTPTVEMIAHI-UHFFFAOYSA-N n-[4-[(5-chlorothiophen-2-yl)methyl-methylamino]-2-methylphenyl]-2-(4-fluorophenyl)acetamide Chemical compound C=1C=C(NC(=O)CC=2C=CC(F)=CC=2)C(C)=CC=1N(C)CC1=CC=C(Cl)S1 XFEGTPTVEMIAHI-UHFFFAOYSA-N 0.000 claims description 2
• BBSKYLLMPFIUPS-UHFFFAOYSA-N n-[4-[(5-chlorothiophen-2-yl)methyl-methylamino]-2-methylphenyl]-2-(4-methoxyphenyl)acetamide Chemical compound C1=CC(OC)=CC=C1CC(=O)NC1=CC=C(N(C)CC=2SC(Cl)=CC=2)C=C1C BBSKYLLMPFIUPS-UHFFFAOYSA-N 0.000 claims description 2
• LVTRCLBSFHCSJM-UHFFFAOYSA-N n-[4-[(5-chlorothiophen-2-yl)methyl-methylamino]-2-methylphenyl]-2-phenylacetamide Chemical compound C=1C=C(NC(=O)CC=2C=CC=CC=2)C(C)=CC=1N(C)CC1=CC=C(Cl)S1 LVTRCLBSFHCSJM-UHFFFAOYSA-N 0.000 claims description 2
• FZSKMPVDJNZYPW-UHFFFAOYSA-N n-[4-[(5-chlorothiophen-2-yl)methyl-methylamino]-2-methylphenyl]-2-thiophen-2-ylacetamide Chemical compound C=1C=C(NC(=O)CC=2SC=CC=2)C(C)=CC=1N(C)CC1=CC=C(Cl)S1 FZSKMPVDJNZYPW-UHFFFAOYSA-N 0.000 claims description 2
• PMDHTUCYTXCBRV-UHFFFAOYSA-N n-[4-[(5-chlorothiophen-2-yl)methyl-methylamino]-2-methylphenyl]-3-cyclohexylpropanamide Chemical compound C=1C=C(NC(=O)CCC2CCCCC2)C(C)=CC=1N(C)CC1=CC=C(Cl)S1 PMDHTUCYTXCBRV-UHFFFAOYSA-N 0.000 claims description 2
• MQGPHTBVVQWZAS-UHFFFAOYSA-N n-[4-[(5-chlorothiophen-2-yl)methyl-methylamino]-2-methylphenyl]butanamide Chemical compound C1=C(C)C(NC(=O)CCC)=CC=C1N(C)CC1=CC=C(Cl)S1 MQGPHTBVVQWZAS-UHFFFAOYSA-N 0.000 claims description 2
• SBGPXKACAAELIX-UHFFFAOYSA-N n-[4-[(5-chlorothiophen-2-yl)methyl-methylamino]-2-methylphenyl]cyclobutanecarboxamide Chemical compound C=1C=C(NC(=O)C2CCC2)C(C)=CC=1N(C)CC1=CC=C(Cl)S1 SBGPXKACAAELIX-UHFFFAOYSA-N 0.000 claims description 2
• BYYDMVUYFUAFTC-UHFFFAOYSA-N n-[4-[(5-chlorothiophen-2-yl)methyl-methylamino]-2-methylphenyl]cyclohexanecarboxamide Chemical compound C=1C=C(NC(=O)C2CCCCC2)C(C)=CC=1N(C)CC1=CC=C(Cl)S1 BYYDMVUYFUAFTC-UHFFFAOYSA-N 0.000 claims description 2
• ODIRDRIAAMZLCL-UHFFFAOYSA-N n-[4-[(5-chlorothiophen-2-yl)methyl-methylamino]-2-methylphenyl]cyclopentanecarboxamide Chemical compound C=1C=C(NC(=O)C2CCCC2)C(C)=CC=1N(C)CC1=CC=C(Cl)S1 ODIRDRIAAMZLCL-UHFFFAOYSA-N 0.000 claims description 2
• CYGSZWQLHYXDPR-UHFFFAOYSA-N n-[4-[(5-chlorothiophen-2-yl)methyl-methylamino]-2-methylphenyl]cyclopropanecarboxamide Chemical compound C=1C=C(NC(=O)C2CC2)C(C)=CC=1N(C)CC1=CC=C(Cl)S1 CYGSZWQLHYXDPR-UHFFFAOYSA-N 0.000 claims description 2
• VCUGNXTWGUQSIK-UHFFFAOYSA-N n-[4-[(5-chlorothiophen-2-yl)methyl-methylamino]-2-methylphenyl]pentanamide Chemical compound C1=C(C)C(NC(=O)CCCC)=CC=C1N(C)CC1=CC=C(Cl)S1 VCUGNXTWGUQSIK-UHFFFAOYSA-N 0.000 claims description 2
• RHEJEMHTZMPVHX-UHFFFAOYSA-N n-[4-[(5-chlorothiophen-2-yl)methylamino]-2-[4-(dimethylamino)phenyl]phenyl]-2-(4-fluorophenyl)acetamide Chemical compound C1=CC(N(C)C)=CC=C1C1=CC(NCC=2SC(Cl)=CC=2)=CC=C1NC(=O)CC1=CC=C(F)C=C1 RHEJEMHTZMPVHX-UHFFFAOYSA-N 0.000 claims description 2
• TXYYXEJXGQEJQO-UHFFFAOYSA-N n-[4-[(5-chlorothiophen-2-yl)methylamino]-2-iodophenyl]-2-(4-fluorophenyl)acetamide Chemical compound C1=CC(F)=CC=C1CC(=O)NC(C(=C1)I)=CC=C1NCC1=CC=C(Cl)S1 TXYYXEJXGQEJQO-UHFFFAOYSA-N 0.000 claims description 2
• NFTGAJLMMXINJN-UHFFFAOYSA-N n-[4-[(5-chlorothiophen-2-yl)methylamino]-2-methoxyphenyl]butanamide Chemical compound C1=C(OC)C(NC(=O)CCC)=CC=C1NCC1=CC=C(Cl)S1 NFTGAJLMMXINJN-UHFFFAOYSA-N 0.000 claims description 2
• ZNDKCOPIFNSNSB-UHFFFAOYSA-N n-[4-[(6-chloropyridin-3-yl)methylamino]-2-methylphenyl]-2-(4-fluorophenyl)acetamide Chemical compound C=1C=C(NC(=O)CC=2C=CC(F)=CC=2)C(C)=CC=1NCC1=CC=C(Cl)N=C1 ZNDKCOPIFNSNSB-UHFFFAOYSA-N 0.000 claims description 2
• TWOAAVBTWULEDV-UHFFFAOYSA-N n-[4-[2-(2-chlorophenyl)morpholin-4-yl]-2,6-dimethylphenyl]-2-cyclopentylacetamide Chemical compound CC1=CC(N2CC(OCC2)C=2C(=CC=CC=2)Cl)=CC(C)=C1NC(=O)CC1CCCC1 TWOAAVBTWULEDV-UHFFFAOYSA-N 0.000 claims description 2
• HYHPENAHMAZITK-UHFFFAOYSA-N n-[4-[2-(2-chlorophenyl)thiomorpholin-4-yl]-2,6-dimethylphenyl]-2-cyclopentylacetamide Chemical compound CC1=CC(N2CC(SCC2)C=2C(=CC=CC=2)Cl)=CC(C)=C1NC(=O)CC1CCCC1 HYHPENAHMAZITK-UHFFFAOYSA-N 0.000 claims description 2
• HPSQCKGKVCFDOI-UHFFFAOYSA-N n-[4-[[(5-chloropyridin-2-yl)amino]methyl]-2,6-dimethylphenyl]-2-cyclopentylacetamide Chemical compound C=1C(C)=C(NC(=O)CC2CCCC2)C(C)=CC=1CNC1=CC=C(Cl)C=N1 HPSQCKGKVCFDOI-UHFFFAOYSA-N 0.000 claims description 2
• MAABUWLWOVWWDB-UHFFFAOYSA-N n-[4-[[5-(4-chlorophenoxy)-1,3-dimethylpyrazol-4-yl]methylamino]-2-methylphenyl]-2,2-dimethylpropanamide Chemical compound C=1C=C(NC(=O)C(C)(C)C)C(C)=CC=1NCC=1C(C)=NN(C)C=1OC1=CC=C(Cl)C=C1 MAABUWLWOVWWDB-UHFFFAOYSA-N 0.000 claims description 2
• XETNUEHTWCZNAQ-UHFFFAOYSA-N n-[4-[[6-(4-cyanophenoxy)pyridin-3-yl]methylamino]-2-methylphenyl]-2-(4-fluorophenyl)acetamide Chemical compound C=1C=C(NC(=O)CC=2C=CC(F)=CC=2)C(C)=CC=1NCC(C=N1)=CC=C1OC1=CC=C(C#N)C=C1 XETNUEHTWCZNAQ-UHFFFAOYSA-N 0.000 claims description 2
• CXLNABRKNCFEPE-UHFFFAOYSA-N n-[4-amino-6-methyl-2-[[4-(trifluoromethyl)phenyl]methylamino]pyrimidin-5-yl]-2-(3-chlorophenyl)acetamide Chemical compound N=1C(N)=C(NC(=O)CC=2C=C(Cl)C=CC=2)C(C)=NC=1NCC1=CC=C(C(F)(F)F)C=C1 CXLNABRKNCFEPE-UHFFFAOYSA-N 0.000 claims description 2
• XVSOQDVGOHMGII-UHFFFAOYSA-N n-[4-amino-6-methyl-2-[[4-(trifluoromethyl)phenyl]methylamino]pyrimidin-5-yl]-2-(4-fluorophenyl)acetamide Chemical compound N=1C(N)=C(NC(=O)CC=2C=CC(F)=CC=2)C(C)=NC=1NCC1=CC=C(C(F)(F)F)C=C1 XVSOQDVGOHMGII-UHFFFAOYSA-N 0.000 claims description 2
• MADIUWVCWDQSFO-UHFFFAOYSA-N n-[4-amino-6-methyl-2-[[4-(trifluoromethyl)phenyl]methylamino]pyrimidin-5-yl]-2-cyclopentylacetamide Chemical compound N=1C(N)=C(NC(=O)CC2CCCC2)C(C)=NC=1NCC1=CC=C(C(F)(F)F)C=C1 MADIUWVCWDQSFO-UHFFFAOYSA-N 0.000 claims description 2
• ORCPEBUYIDIIBI-UHFFFAOYSA-N n-[4-amino-6-methyl-2-[[4-(trifluoromethyl)phenyl]methylamino]pyrimidin-5-yl]-3,3-dimethylbutanamide Chemical compound NC1=C(NC(=O)CC(C)(C)C)C(C)=NC(NCC=2C=CC(=CC=2)C(F)(F)F)=N1 ORCPEBUYIDIIBI-UHFFFAOYSA-N 0.000 claims description 2
• OSWHOUIOMBVTRL-UHFFFAOYSA-N n-[4-amino-6-methyl-2-[[4-(trifluoromethyl)phenyl]methylamino]pyrimidin-5-yl]hexanamide Chemical compound N1=C(N)C(NC(=O)CCCCC)=C(C)N=C1NCC1=CC=C(C(F)(F)F)C=C1 OSWHOUIOMBVTRL-UHFFFAOYSA-N 0.000 claims description 2
• GIGOQAZYYLYRQV-UHFFFAOYSA-N n-[4-chloro-1-[(5-chlorothiophen-2-yl)methyl]-2,3-dihydroindol-5-yl]-3,3-dimethylbutanamide Chemical compound C1CC2=C(Cl)C(NC(=O)CC(C)(C)C)=CC=C2N1CC1=CC=C(Cl)S1 GIGOQAZYYLYRQV-UHFFFAOYSA-N 0.000 claims description 2
• LOCLEXPLOMOTOG-UHFFFAOYSA-N n-[4-chloro-1-[[4-(trifluoromethyl)phenyl]methyl]-2,3-dihydroindol-5-yl]-3,3-dimethylbutanamide Chemical compound C1CC2=C(Cl)C(NC(=O)CC(C)(C)C)=CC=C2N1CC1=CC=C(C(F)(F)F)C=C1 LOCLEXPLOMOTOG-UHFFFAOYSA-N 0.000 claims description 2
• WMITZKMKKZVUOA-UHFFFAOYSA-N n-[6-amino-1-[(4-fluorophenyl)methyl]-2,3-dihydroindol-5-yl]-3,3-dimethylbutanamide Chemical compound C1=2C=C(N)C(NC(=O)CC(C)(C)C)=CC=2CCN1CC1=CC=C(F)C=C1 WMITZKMKKZVUOA-UHFFFAOYSA-N 0.000 claims description 2
• XFXDQNZGCOJIKK-UHFFFAOYSA-N n-[6-amino-1-[(5-chlorothiophen-2-yl)methyl]-2,3-dihydroindol-5-yl]-2,2-dimethylpropanamide Chemical compound C1=2C=C(N)C(NC(=O)C(C)(C)C)=CC=2CCN1CC1=CC=C(Cl)S1 XFXDQNZGCOJIKK-UHFFFAOYSA-N 0.000 claims description 2
• JNEYEYIXWBWWGG-UHFFFAOYSA-N n-[6-amino-1-[(5-chlorothiophen-2-yl)methyl]-2,3-dihydroindol-5-yl]-3,3-dimethylbutanamide Chemical compound C1=2C=C(N)C(NC(=O)CC(C)(C)C)=CC=2CCN1CC1=CC=C(Cl)S1 JNEYEYIXWBWWGG-UHFFFAOYSA-N 0.000 claims description 2
• PFXGSJZQUMCENI-UHFFFAOYSA-N n-[6-amino-1-[[3-fluoro-4-(trifluoromethyl)phenyl]methyl]-2,3-dihydroindol-5-yl]-3,3-dimethylbutanamide Chemical compound C1=2C=C(N)C(NC(=O)CC(C)(C)C)=CC=2CCN1CC1=CC=C(C(F)(F)F)C(F)=C1 PFXGSJZQUMCENI-UHFFFAOYSA-N 0.000 claims description 2
• BDNMQAIDXMFIPX-UHFFFAOYSA-N n-[6-amino-1-[[4-(trifluoromethyl)phenyl]methyl]-2,3-dihydroindol-5-yl]-2,2-dimethylpropanamide Chemical compound C1=2C=C(N)C(NC(=O)C(C)(C)C)=CC=2CCN1CC1=CC=C(C(F)(F)F)C=C1 BDNMQAIDXMFIPX-UHFFFAOYSA-N 0.000 claims description 2
• LEAGGTMYQUKNJZ-UHFFFAOYSA-N n-[6-amino-1-[[4-(trifluoromethyl)phenyl]methyl]-2,3-dihydroindol-5-yl]-2-(4-fluorophenyl)acetamide Chemical compound C1CC=2C=C(NC(=O)CC=3C=CC(F)=CC=3)C(N)=CC=2N1CC1=CC=C(C(F)(F)F)C=C1 LEAGGTMYQUKNJZ-UHFFFAOYSA-N 0.000 claims description 2
• IAZYLAOKVSTMMF-UHFFFAOYSA-N n-[6-amino-1-[[4-(trifluoromethyl)phenyl]methyl]-2,3-dihydroindol-5-yl]-3,3-dimethylbutanamide Chemical compound C1=2C=C(N)C(NC(=O)CC(C)(C)C)=CC=2CCN1CC1=CC=C(C(F)(F)F)C=C1 IAZYLAOKVSTMMF-UHFFFAOYSA-N 0.000 claims description 2
• SJZUZZGCSNZQTD-UHFFFAOYSA-N n-[6-bromo-1-[(5-chlorothiophen-2-yl)methyl]-2,3-dihydroindol-5-yl]-3,3-dimethylbutanamide Chemical compound C1=2C=C(Br)C(NC(=O)CC(C)(C)C)=CC=2CCN1CC1=CC=C(Cl)S1 SJZUZZGCSNZQTD-UHFFFAOYSA-N 0.000 claims description 2
• ZAXBJTRAIGCMSW-UHFFFAOYSA-N n-[6-bromo-1-[[4-(trifluoromethyl)phenyl]methyl]-2,3-dihydroindol-5-yl]-3,3-dimethylbutanamide Chemical compound C1=2C=C(Br)C(NC(=O)CC(C)(C)C)=CC=2CCN1CC1=CC=C(C(F)(F)F)C=C1 ZAXBJTRAIGCMSW-UHFFFAOYSA-N 0.000 claims description 2
• FUZZWVXGSFPDMH-UHFFFAOYSA-N n-hexanoic acid Natural products CCCCCC(O)=O FUZZWVXGSFPDMH-UHFFFAOYSA-N 0.000 claims description 2
• 230000002085 persistent effect Effects 0.000 claims description 2
• QYNJALBPNQXKOG-UHFFFAOYSA-N phenyl n-[2-chloro-4-[(5-chlorothiophen-2-yl)methyl-methylamino]phenyl]carbamate Chemical compound C=1C=C(NC(=O)OC=2C=CC=CC=2)C(Cl)=CC=1N(C)CC1=CC=C(Cl)S1 QYNJALBPNQXKOG-UHFFFAOYSA-N 0.000 claims description 2
• MXUJFQOMTXBKEL-UHFFFAOYSA-N propan-2-yl n-[4-[(5-bromothiophen-2-yl)methylamino]-2-methoxyphenyl]carbamate Chemical compound C1=C(NC(=O)OC(C)C)C(OC)=CC(NCC=2SC(Br)=CC=2)=C1 MXUJFQOMTXBKEL-UHFFFAOYSA-N 0.000 claims description 2
• AQMMAJZBLIFENA-UHFFFAOYSA-N propyl n-(4-bromo-2,6-dimethylphenyl)carbamate Chemical compound CCCOC(=O)NC1=C(C)C=C(Br)C=C1C AQMMAJZBLIFENA-UHFFFAOYSA-N 0.000 claims description 2
• SIMHCLCXJNWNEF-UHFFFAOYSA-N propyl n-[1-[(4-fluorophenyl)methyl]-2,3-dihydroindol-5-yl]carbamate Chemical compound C1CC2=CC(NC(=O)OCCC)=CC=C2N1CC1=CC=C(F)C=C1 SIMHCLCXJNWNEF-UHFFFAOYSA-N 0.000 claims description 2
• PRTLUEMAYPPJKC-UHFFFAOYSA-N propyl n-[1-[(5-chlorothiophen-2-yl)methyl]-2,3-dihydroindol-5-yl]carbamate Chemical compound C1CC2=CC(NC(=O)OCCC)=CC=C2N1CC1=CC=C(Cl)S1 PRTLUEMAYPPJKC-UHFFFAOYSA-N 0.000 claims description 2
• YVNQJVUAEHJVSD-UHFFFAOYSA-N propyl n-[2,6-dimethyl-4-[(4-methyl-2-phenylpyrimidin-5-yl)methylamino]phenyl]carbamate Chemical compound C1=C(C)C(NC(=O)OCCC)=C(C)C=C1NCC1=CN=C(C=2C=CC=CC=2)N=C1C YVNQJVUAEHJVSD-UHFFFAOYSA-N 0.000 claims description 2
• SCZBYOLAIVJLAL-UHFFFAOYSA-N propyl n-[2,6-dimethyl-4-[[4-(trifluoromethyl)anilino]methyl]phenyl]carbamate Chemical compound C1=C(C)C(NC(=O)OCCC)=C(C)C=C1CNC1=CC=C(C(F)(F)F)C=C1 SCZBYOLAIVJLAL-UHFFFAOYSA-N 0.000 claims description 2
• JRUNPSYYKOZIFI-UHFFFAOYSA-N propyl n-[2,6-dimethyl-4-[[4-(trifluoromethyl)phenyl]methylamino]phenyl]carbamate Chemical compound C1=C(C)C(NC(=O)OCCC)=C(C)C=C1NCC1=CC=C(C(F)(F)F)C=C1 JRUNPSYYKOZIFI-UHFFFAOYSA-N 0.000 claims description 2
• KAMAAAVPELJCKX-UHFFFAOYSA-N propyl n-[2,6-dimethyl-4-[[6-(4-methylphenoxy)pyridin-3-yl]methylamino]phenyl]carbamate Chemical compound C1=C(C)C(NC(=O)OCCC)=C(C)C=C1NCC(C=N1)=CC=C1OC1=CC=C(C)C=C1 KAMAAAVPELJCKX-UHFFFAOYSA-N 0.000 claims description 2
• GUWWVMJPRYOTKR-UHFFFAOYSA-N propyl n-[2-(furan-2-yl)-4-[(4-propan-2-ylphenyl)methylamino]phenyl]carbamate Chemical compound C1=C(C=2OC=CC=2)C(NC(=O)OCCC)=CC=C1NCC1=CC=C(C(C)C)C=C1 GUWWVMJPRYOTKR-UHFFFAOYSA-N 0.000 claims description 2
• SNWAFDKDRJRUCS-UHFFFAOYSA-N propyl n-[2-(trifluoromethyl)-4-[[4-(trifluoromethyl)phenyl]methylamino]phenyl]carbamate Chemical compound C1=C(C(F)(F)F)C(NC(=O)OCCC)=CC=C1NCC1=CC=C(C(F)(F)F)C=C1 SNWAFDKDRJRUCS-UHFFFAOYSA-N 0.000 claims description 2
• KYYUTTNFUCOPCS-UHFFFAOYSA-N propyl n-[2-amino-4-(1-benzothiophen-2-ylmethylamino)phenyl]carbamate Chemical compound C1=C(N)C(NC(=O)OCCC)=CC=C1NCC1=CC2=CC=CC=C2S1 KYYUTTNFUCOPCS-UHFFFAOYSA-N 0.000 claims description 2
• NHFRVRNKRNDFPO-UHFFFAOYSA-N propyl n-[2-amino-4-(1-benzothiophen-3-ylmethylamino)phenyl]carbamate Chemical compound C1=C(N)C(NC(=O)OCCC)=CC=C1NCC1=CSC2=CC=CC=C12 NHFRVRNKRNDFPO-UHFFFAOYSA-N 0.000 claims description 2
• QHMVGVWNQLCEIC-UHFFFAOYSA-N propyl n-[2-bromo-4-[(4-methylsulfanylphenyl)methylamino]phenyl]carbamate Chemical compound C1=C(Br)C(NC(=O)OCCC)=CC=C1NCC1=CC=C(SC)C=C1 QHMVGVWNQLCEIC-UHFFFAOYSA-N 0.000 claims description 2
• XSCQBIFKOLPBQP-UHFFFAOYSA-N propyl n-[2-bromo-4-[(4-propan-2-ylphenyl)methylamino]phenyl]carbamate Chemical compound C1=C(Br)C(NC(=O)OCCC)=CC=C1NCC1=CC=C(C(C)C)C=C1 XSCQBIFKOLPBQP-UHFFFAOYSA-N 0.000 claims description 2
• YLYPVBMLXLRFPR-UHFFFAOYSA-N propyl n-[2-bromo-4-[(4-tert-butylphenyl)methyl-methylamino]phenyl]carbamate Chemical compound C1=C(Br)C(NC(=O)OCCC)=CC=C1N(C)CC1=CC=C(C(C)(C)C)C=C1 YLYPVBMLXLRFPR-UHFFFAOYSA-N 0.000 claims description 2
• CSVKGTLKBFHNBH-UHFFFAOYSA-N propyl n-[2-bromo-4-[(4-tert-butylphenyl)methylamino]phenyl]carbamate Chemical compound C1=C(Br)C(NC(=O)OCCC)=CC=C1NCC1=CC=C(C(C)(C)C)C=C1 CSVKGTLKBFHNBH-UHFFFAOYSA-N 0.000 claims description 2
• BWNNQSDXPGZXIU-UHFFFAOYSA-N propyl n-[2-bromo-4-[(5-bromothiophen-2-yl)methyl-methylamino]phenyl]carbamate Chemical compound C1=C(Br)C(NC(=O)OCCC)=CC=C1N(C)CC1=CC=C(Br)S1 BWNNQSDXPGZXIU-UHFFFAOYSA-N 0.000 claims description 2
• RDVVIESVSGRXJS-UHFFFAOYSA-N propyl n-[2-bromo-4-[(5-bromothiophen-2-yl)methylamino]phenyl]carbamate Chemical compound C1=C(Br)C(NC(=O)OCCC)=CC=C1NCC1=CC=C(Br)S1 RDVVIESVSGRXJS-UHFFFAOYSA-N 0.000 claims description 2
• RFBPNVJIXZBIRC-UHFFFAOYSA-N propyl n-[2-bromo-4-[(5-chlorothiophen-2-yl)methyl-methylamino]phenyl]carbamate Chemical compound C1=C(Br)C(NC(=O)OCCC)=CC=C1N(C)CC1=CC=C(Cl)S1 RFBPNVJIXZBIRC-UHFFFAOYSA-N 0.000 claims description 2
• UJYLUVNQOIWRHI-UHFFFAOYSA-N propyl n-[2-bromo-4-[(5-chlorothiophen-2-yl)methylamino]phenyl]carbamate Chemical compound C1=C(Br)C(NC(=O)OCCC)=CC=C1NCC1=CC=C(Cl)S1 UJYLUVNQOIWRHI-UHFFFAOYSA-N 0.000 claims description 2
• ZVJQBZOVZAKHCL-UHFFFAOYSA-N propyl n-[2-bromo-4-[[4-(trifluoromethyl)phenyl]methylamino]phenyl]carbamate Chemical compound C1=C(Br)C(NC(=O)OCCC)=CC=C1NCC1=CC=C(C(F)(F)F)C=C1 ZVJQBZOVZAKHCL-UHFFFAOYSA-N 0.000 claims description 2
• FJOCXCMSKXJZSK-UHFFFAOYSA-N propyl n-[2-bromo-4-[methyl-[(4-propan-2-ylphenyl)methyl]amino]phenyl]carbamate Chemical compound C1=C(Br)C(NC(=O)OCCC)=CC=C1N(C)CC1=CC=C(C(C)C)C=C1 FJOCXCMSKXJZSK-UHFFFAOYSA-N 0.000 claims description 2
• TXNONQHAXVVONT-UHFFFAOYSA-N propyl n-[2-bromo-4-[methyl-[[4-(trifluoromethyl)phenyl]methyl]amino]phenyl]carbamate Chemical compound C1=C(Br)C(NC(=O)OCCC)=CC=C1N(C)CC1=CC=C(C(F)(F)F)C=C1 TXNONQHAXVVONT-UHFFFAOYSA-N 0.000 claims description 2
• CYWFLRNPZAOFSD-UHFFFAOYSA-N propyl n-[2-chloro-4-[(4-fluorophenyl)methylamino]phenyl]carbamate Chemical compound C1=C(Cl)C(NC(=O)OCCC)=CC=C1NCC1=CC=C(F)C=C1 CYWFLRNPZAOFSD-UHFFFAOYSA-N 0.000 claims description 2
• YJOPZVBUMWERJC-UHFFFAOYSA-N propyl n-[2-chloro-4-[(5-chlorothiophen-2-yl)methyl-methylamino]phenyl]carbamate Chemical compound C1=C(Cl)C(NC(=O)OCCC)=CC=C1N(C)CC1=CC=C(Cl)S1 YJOPZVBUMWERJC-UHFFFAOYSA-N 0.000 claims description 2
• AFEGKGPOQWHFQJ-UHFFFAOYSA-N propyl n-[2-chloro-4-[(5-chlorothiophen-2-yl)methylamino]phenyl]carbamate Chemical compound C1=C(Cl)C(NC(=O)OCCC)=CC=C1NCC1=CC=C(Cl)S1 AFEGKGPOQWHFQJ-UHFFFAOYSA-N 0.000 claims description 2
• UGBFSKGLWGZLCW-UHFFFAOYSA-N propyl n-[2-chloro-4-[(5-methylthiophen-2-yl)methylamino]phenyl]carbamate Chemical compound C1=C(Cl)C(NC(=O)OCCC)=CC=C1NCC1=CC=C(C)S1 UGBFSKGLWGZLCW-UHFFFAOYSA-N 0.000 claims description 2
• YEXHSLUGSAGMJM-UHFFFAOYSA-N propyl n-[2-chloro-4-[methyl-[[4-(trifluoromethyl)phenyl]methyl]amino]phenyl]carbamate Chemical compound C1=C(Cl)C(NC(=O)OCCC)=CC=C1N(C)CC1=CC=C(C(F)(F)F)C=C1 YEXHSLUGSAGMJM-UHFFFAOYSA-N 0.000 claims description 2
• HMQPLANFTAPTBN-UHFFFAOYSA-N propyl n-[2-cyano-4-[[4-(trifluoromethyl)phenyl]methylamino]phenyl]carbamate Chemical compound C1=C(C#N)C(NC(=O)OCCC)=CC=C1NCC1=CC=C(C(F)(F)F)C=C1 HMQPLANFTAPTBN-UHFFFAOYSA-N 0.000 claims description 2
• QMKMMGGJLUWMDT-UHFFFAOYSA-N propyl n-[2-iodo-4-[(4-methylsulfanylphenyl)methylamino]phenyl]carbamate Chemical compound C1=C(I)C(NC(=O)OCCC)=CC=C1NCC1=CC=C(SC)C=C1 QMKMMGGJLUWMDT-UHFFFAOYSA-N 0.000 claims description 2
• BXPLVYLJBOHLAC-UHFFFAOYSA-N propyl n-[2-iodo-4-[(4-propan-2-ylphenyl)methylamino]phenyl]carbamate Chemical compound C1=C(I)C(NC(=O)OCCC)=CC=C1NCC1=CC=C(C(C)C)C=C1 BXPLVYLJBOHLAC-UHFFFAOYSA-N 0.000 claims description 2
• FNIFMWOIQHIEBH-UHFFFAOYSA-N propyl n-[2-iodo-4-[[4-(4-methylpiperazin-1-yl)phenyl]methylamino]phenyl]carbamate Chemical compound C1=C(I)C(NC(=O)OCCC)=CC=C1NCC1=CC=C(N2CCN(C)CC2)C=C1 FNIFMWOIQHIEBH-UHFFFAOYSA-N 0.000 claims description 2
• NUIPDYRCSYMGEO-UHFFFAOYSA-N propyl n-[2-iodo-4-[[4-(trifluoromethyl)phenyl]methylamino]phenyl]carbamate Chemical compound C1=C(I)C(NC(=O)OCCC)=CC=C1NCC1=CC=C(C(F)(F)F)C=C1 NUIPDYRCSYMGEO-UHFFFAOYSA-N 0.000 claims description 2
• RJBCLHKMVOWSML-UHFFFAOYSA-N propyl n-[2-methoxy-4-[methyl-[(5-methylthiophen-2-yl)methyl]amino]phenyl]carbamate Chemical compound C1=C(OC)C(NC(=O)OCCC)=CC=C1N(C)CC1=CC=C(C)S1 RJBCLHKMVOWSML-UHFFFAOYSA-N 0.000 claims description 2
• VACFMSSWACPZHI-UHFFFAOYSA-N propyl n-[2-methyl-4-[(4-propan-2-ylphenyl)methylamino]phenyl]carbamate Chemical compound C1=C(C)C(NC(=O)OCCC)=CC=C1NCC1=CC=C(C(C)C)C=C1 VACFMSSWACPZHI-UHFFFAOYSA-N 0.000 claims description 2
• AAPHGYAVTQDBAX-UHFFFAOYSA-N propyl n-[2-methyl-4-[(5-methylthiophen-2-yl)methylamino]phenyl]carbamate Chemical compound C1=C(C)C(NC(=O)OCCC)=CC=C1NCC1=CC=C(C)S1 AAPHGYAVTQDBAX-UHFFFAOYSA-N 0.000 claims description 2
• QVCSVXPJFKCBPU-UHFFFAOYSA-N propyl n-[2-methyl-4-[(5-phenylthiophen-2-yl)methylamino]phenyl]carbamate Chemical compound C1=C(C)C(NC(=O)OCCC)=CC=C1NCC1=CC=C(C=2C=CC=CC=2)S1 QVCSVXPJFKCBPU-UHFFFAOYSA-N 0.000 claims description 2
• PINFNGLHVSTBBG-UHFFFAOYSA-N propyl n-[2-methyl-4-[methyl-[(4-methylsulfanylphenyl)methyl]amino]phenyl]carbamate Chemical compound C1=C(C)C(NC(=O)OCCC)=CC=C1N(C)CC1=CC=C(SC)C=C1 PINFNGLHVSTBBG-UHFFFAOYSA-N 0.000 claims description 2
• GOJPEGLCQDFVPT-UHFFFAOYSA-N propyl n-[2-methyl-4-[methyl-[(4-propan-2-ylphenyl)methyl]amino]phenyl]carbamate Chemical compound C1=C(C)C(NC(=O)OCCC)=CC=C1N(C)CC1=CC=C(C(C)C)C=C1 GOJPEGLCQDFVPT-UHFFFAOYSA-N 0.000 claims description 2
• QFDDBMBVVIVHEO-UHFFFAOYSA-N propyl n-[2-methyl-4-[methyl-[[4-(trifluoromethyl)phenyl]methyl]amino]phenyl]carbamate Chemical compound C1=C(C)C(NC(=O)OCCC)=CC=C1N(C)CC1=CC=C(C(F)(F)F)C=C1 QFDDBMBVVIVHEO-UHFFFAOYSA-N 0.000 claims description 2
• UZUYYMCKQDLORF-UHFFFAOYSA-N propyl n-[2-phenyl-4-[(4-propan-2-ylphenyl)methylamino]phenyl]carbamate Chemical compound C1=C(C=2C=CC=CC=2)C(NC(=O)OCCC)=CC=C1NCC1=CC=C(C(C)C)C=C1 UZUYYMCKQDLORF-UHFFFAOYSA-N 0.000 claims description 2
• CUZJSPJHSHZBAK-UHFFFAOYSA-N propyl n-[4-(1-benzofuran-2-ylmethylamino)-2-chlorophenyl]carbamate Chemical compound C1=C(Cl)C(NC(=O)OCCC)=CC=C1NCC1=CC2=CC=CC=C2O1 CUZJSPJHSHZBAK-UHFFFAOYSA-N 0.000 claims description 2
• NPXGSEYMDJBGGG-UHFFFAOYSA-N propyl n-[4-(1-benzofuran-2-ylmethylamino)-2-methylphenyl]carbamate Chemical compound C1=C(C)C(NC(=O)OCCC)=CC=C1NCC1=CC2=CC=CC=C2O1 NPXGSEYMDJBGGG-UHFFFAOYSA-N 0.000 claims description 2
• OKURPJNOOJFAPL-UHFFFAOYSA-N propyl n-[4-(1-benzothiophen-2-ylmethylamino)-2-chlorophenyl]carbamate Chemical compound C1=C(Cl)C(NC(=O)OCCC)=CC=C1NCC1=CC2=CC=CC=C2S1 OKURPJNOOJFAPL-UHFFFAOYSA-N 0.000 claims description 2
• HIZHMAAIAJCCJA-UHFFFAOYSA-N propyl n-[4-(1-benzothiophen-2-ylmethylamino)-2-methylphenyl]carbamate Chemical compound C1=C(C)C(NC(=O)OCCC)=CC=C1NCC1=CC2=CC=CC=C2S1 HIZHMAAIAJCCJA-UHFFFAOYSA-N 0.000 claims description 2
• UIDDHJYOJQKCBL-UHFFFAOYSA-N propyl n-[4-[(3,5-difluoroanilino)methyl]-2,6-dimethylphenyl]carbamate Chemical compound C1=C(C)C(NC(=O)OCCC)=C(C)C=C1CNC1=CC(F)=CC(F)=C1 UIDDHJYOJQKCBL-UHFFFAOYSA-N 0.000 claims description 2
• YDWHGGSSEKVEEC-UHFFFAOYSA-N propyl n-[4-[(3-fluoroanilino)methyl]-2,6-dimethylphenyl]carbamate Chemical compound C1=C(C)C(NC(=O)OCCC)=C(C)C=C1CNC1=CC=CC(F)=C1 YDWHGGSSEKVEEC-UHFFFAOYSA-N 0.000 claims description 2
• AQIFYVHPKXHKSC-UHFFFAOYSA-N propyl n-[4-[(4-chloroanilino)methyl]-2,6-dimethylphenyl]carbamate Chemical compound C1=C(C)C(NC(=O)OCCC)=C(C)C=C1CNC1=CC=C(Cl)C=C1 AQIFYVHPKXHKSC-UHFFFAOYSA-N 0.000 claims description 2
• MMKYWFRMYQWGMK-UHFFFAOYSA-N propyl n-[4-[(4-fluoroanilino)methyl]-2,6-dimethylphenyl]carbamate Chemical compound C1=C(C)C(NC(=O)OCCC)=C(C)C=C1CNC1=CC=C(F)C=C1 MMKYWFRMYQWGMK-UHFFFAOYSA-N 0.000 claims description 2
• FCHLJBHFHBTVKP-UHFFFAOYSA-N propyl n-[4-[(4-fluorophenyl)methyl-methylamino]-2-methoxyphenyl]carbamate Chemical compound C1=C(OC)C(NC(=O)OCCC)=CC=C1N(C)CC1=CC=C(F)C=C1 FCHLJBHFHBTVKP-UHFFFAOYSA-N 0.000 claims description 2
• ZUMWFZLNACCXQY-UHFFFAOYSA-N propyl n-[4-[(4-fluorophenyl)methylamino]-2-methylphenyl]carbamate Chemical compound C1=C(C)C(NC(=O)OCCC)=CC=C1NCC1=CC=C(F)C=C1 ZUMWFZLNACCXQY-UHFFFAOYSA-N 0.000 claims description 2
• LFRNMSVOMBZWHX-UHFFFAOYSA-N propyl n-[4-[(4-fluorophenyl)methylamino]-2-phenylphenyl]carbamate Chemical compound C1=C(C=2C=CC=CC=2)C(NC(=O)OCCC)=CC=C1NCC1=CC=C(F)C=C1 LFRNMSVOMBZWHX-UHFFFAOYSA-N 0.000 claims description 2
• BHLLLFQNDMQXGM-UHFFFAOYSA-N propyl n-[4-[(4-methoxyanilino)methyl]-2,6-dimethylphenyl]carbamate Chemical compound C1=C(C)C(NC(=O)OCCC)=C(C)C=C1CNC1=CC=C(OC)C=C1 BHLLLFQNDMQXGM-UHFFFAOYSA-N 0.000 claims description 2
• WCEIYJJKLZBVFS-UHFFFAOYSA-N propyl n-[4-[(4-methylsulfanylphenyl)methylamino]-2-(trifluoromethyl)phenyl]carbamate Chemical compound C1=C(C(F)(F)F)C(NC(=O)OCCC)=CC=C1NCC1=CC=C(SC)C=C1 WCEIYJJKLZBVFS-UHFFFAOYSA-N 0.000 claims description 2
• JZWNUSQHKDGSPL-UHFFFAOYSA-N propyl n-[4-[(4-propan-2-ylphenyl)methylamino]-2-(trifluoromethyl)phenyl]carbamate Chemical compound C1=C(C(F)(F)F)C(NC(=O)OCCC)=CC=C1NCC1=CC=C(C(C)C)C=C1 JZWNUSQHKDGSPL-UHFFFAOYSA-N 0.000 claims description 2
• OAYSXZNFPMSWAG-UHFFFAOYSA-N propyl n-[4-[(4-tert-butylphenyl)methyl-methylamino]-2-(trifluoromethyl)phenyl]carbamate Chemical compound C1=C(C(F)(F)F)C(NC(=O)OCCC)=CC=C1N(C)CC1=CC=C(C(C)(C)C)C=C1 OAYSXZNFPMSWAG-UHFFFAOYSA-N 0.000 claims description 2
• VMODJIZIFUHEHH-UHFFFAOYSA-N propyl n-[4-[(4-tert-butylphenyl)methyl-methylamino]-2-chlorophenyl]carbamate Chemical compound C1=C(Cl)C(NC(=O)OCCC)=CC=C1N(C)CC1=CC=C(C(C)(C)C)C=C1 VMODJIZIFUHEHH-UHFFFAOYSA-N 0.000 claims description 2
• GNWHHFNXSDFJRR-UHFFFAOYSA-N propyl n-[4-[(4-tert-butylphenyl)methyl-methylamino]-2-cyanophenyl]carbamate Chemical compound C1=C(C#N)C(NC(=O)OCCC)=CC=C1N(C)CC1=CC=C(C(C)(C)C)C=C1 GNWHHFNXSDFJRR-UHFFFAOYSA-N 0.000 claims description 2
• SIEUTMUKGSAJCV-UHFFFAOYSA-N propyl n-[4-[(4-tert-butylphenyl)methylamino]-2-(trifluoromethyl)phenyl]carbamate Chemical compound C1=C(C(F)(F)F)C(NC(=O)OCCC)=CC=C1NCC1=CC=C(C(C)(C)C)C=C1 SIEUTMUKGSAJCV-UHFFFAOYSA-N 0.000 claims description 2
• HBJYCGYONGRNBT-UHFFFAOYSA-N propyl n-[4-[(4-tert-butylphenyl)methylamino]-2-iodophenyl]carbamate Chemical compound C1=C(I)C(NC(=O)OCCC)=CC=C1NCC1=CC=C(C(C)(C)C)C=C1 HBJYCGYONGRNBT-UHFFFAOYSA-N 0.000 claims description 2
• UHEROFPUOURMRS-UHFFFAOYSA-N propyl n-[4-[(5-bromothiophen-2-yl)methyl-methylamino]-2-(trifluoromethyl)phenyl]carbamate Chemical compound C1=C(C(F)(F)F)C(NC(=O)OCCC)=CC=C1N(C)CC1=CC=C(Br)S1 UHEROFPUOURMRS-UHFFFAOYSA-N 0.000 claims description 2
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