AR119521A1 - DERIVADOS DE ALCOHOL COMO ABRIDORES DEL CANAL DE POTASIO Kv7 - Google Patents
DERIVADOS DE ALCOHOL COMO ABRIDORES DEL CANAL DE POTASIO Kv7Info
- Publication number
- AR119521A1 AR119521A1 ARP200102131A ARP200102131A AR119521A1 AR 119521 A1 AR119521 A1 AR 119521A1 AR P200102131 A ARP200102131 A AR P200102131A AR P200102131 A ARP200102131 A AR P200102131A AR 119521 A1 AR119521 A1 AR 119521A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- potassium channel
- alcohol derivatives
- channel openers
- cycloalkyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C235/08—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atom of at least one of the carboxamide groups bound to an acyclic carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/26—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being saturated and containing rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
- C07C255/32—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring
- C07C255/42—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring the carbon skeleton being further substituted by singly-bound nitrogen atoms, not being further bound to other hetero atoms
- C07C255/44—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring the carbon skeleton being further substituted by singly-bound nitrogen atoms, not being further bound to other hetero atoms at least one of the singly-bound nitrogen atoms being acylated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/04—Systems containing only non-condensed rings with a four-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
- C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Reivindicación 1: Un compuesto de fórmula (1); donde R¹ se selecciona del grupo que consiste en alquilo C₁₋₆, CF₃, CH₂CF₃, CF₂CHF₂, cicloalquilo C₃₋₈, donde dicho cicloalquilo C₃₋₈ puede estar sustituido con 1 ó 2 sustituyentes seleccionados del grupo que consiste de alquilo C₁₋₃, F, CHF₂ y CF₃; y R² es H, alquilo C₁₋₆ o CF₃; o R¹ y R² se combinan para formar cicloalquilo C₃₋₅ opcionalmente sustituido con 1 ó 2 F, CHF₂ o CF₃; y R³ es alquilo C₁₋₃ o CH₂O-alquilo C₁₋₃, dicho alquilo C₁₋₃ o CH₂O-alquilo C₁₋₃ es alquilo sustituido con C&
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP19189750 | 2019-08-02 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR119521A1 true AR119521A1 (es) | 2021-12-22 |
Family
ID=67539339
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP200102131A AR119521A1 (es) | 2019-08-02 | 2020-07-29 | DERIVADOS DE ALCOHOL COMO ABRIDORES DEL CANAL DE POTASIO Kv7 |
Country Status (3)
Country | Link |
---|---|
US (1) | US11548849B2 (es) |
AR (1) | AR119521A1 (es) |
TW (1) | TW202120471A (es) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US10590067B2 (en) * | 2018-02-20 | 2020-03-17 | H. Lundbeck A/S | Alcohol derivatives of carboxamides as Kv7 potassium channel openers |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL152202A0 (en) | 2000-05-26 | 2003-05-29 | Bristol Myers Squibb Co | Human kcnq5 polypeptide and pharmaceutical compositions containing the same |
WO2001096540A2 (en) | 2000-06-11 | 2001-12-20 | Dupont Pharmaceuticals Company | Hepatitis c protease exosite for inhibitor design |
US7091202B2 (en) | 2004-09-15 | 2006-08-15 | Bristol-Myers Squibb Company | 4-arylspirocycloalkyl-2-aminopyrimidine carboxamide KCNQ potassium channel modulators |
EP1983974A1 (en) | 2006-02-07 | 2008-10-29 | H. Lundbeck A/S | Use of kcnq-openers for treating or reducing the symptoms of schizophrenia |
US20090036473A1 (en) | 2006-03-15 | 2009-02-05 | William Dalby Brown | Novel quinazolinone derivatives and their medical use |
US20100256145A1 (en) | 2007-08-01 | 2010-10-07 | H. Lundbeck A/S | Use of kcnq potassium channel openers for reducing symptoms of or treating disorders or conditions wherein the dopaminergic system is disrupted |
TW201024286A (en) | 2008-11-27 | 2010-07-01 | Neurosearch As | Novel compounds |
WO2014145852A2 (en) | 2013-03-15 | 2014-09-18 | Knopp Biosciences Llc | Imidazo(4,5-b) pyridin-2-yl amides as kv7 channel activators |
EP3572405B9 (en) | 2014-09-12 | 2023-12-06 | Biohaven Therapeutics Ltd. | Benzoimidazol-1,2-yl amides as kv7 channel activators |
JP2017095366A (ja) | 2015-11-18 | 2017-06-01 | 持田製薬株式会社 | 新規ビアリールアミド誘導体 |
CN105663136A (zh) | 2016-01-15 | 2016-06-15 | 河北中医学院 | 法舒地尔作为制备选择性Kv7离子通道激活剂药物的应用 |
EP4241843A3 (en) | 2018-02-20 | 2023-09-27 | H. Lundbeck A/S | Alcohol derivatives as kv7 potassium channel openers |
US10590067B2 (en) | 2018-02-20 | 2020-03-17 | H. Lundbeck A/S | Alcohol derivatives of carboxamides as Kv7 potassium channel openers |
-
2020
- 2020-07-29 AR ARP200102131A patent/AR119521A1/es unknown
- 2020-07-30 US US16/943,872 patent/US11548849B2/en active Active
- 2020-07-30 TW TW109125815A patent/TW202120471A/zh unknown
Also Published As
Publication number | Publication date |
---|---|
US20210032196A1 (en) | 2021-02-04 |
US11548849B2 (en) | 2023-01-10 |
TW202120471A (zh) | 2021-06-01 |
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