JP2011511004A - ＰＣＳＫ９遺伝子を標的とするｄｓＲＮＡを送達するための最適化された方法 - Google Patents

ＰＣＳＫ９遺伝子を標的とするｄｓＲＮＡを送達するための最適化された方法 Download PDF

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JP2011511004A
JP2011511004A JP2010545236A JP2010545236A JP2011511004A JP 2011511004 A JP2011511004 A JP 2011511004A JP 2010545236 A JP2010545236 A JP 2010545236A JP 2010545236 A JP2010545236 A JP 2010545236A JP 2011511004 A JP2011511004 A JP 2011511004A
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dsrna
pcsk9
nucleotides
cholesterol
days
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ケビン フィッツジェラルド，
フォージェロルズ， アントニン デ
エイキン アキンク，
ビクター イー． コテリアンスキ，
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Alnylam Pharmaceuticals Inc
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JP2010545236A 2008-01-31 2009-01-30 ＰＣＳＫ９遺伝子を標的とするｄｓＲＮＡを送達するための最適化された方法 Pending JP2011511004A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US2496808P 2008-01-31 2008-01-31
US3908308P 2008-03-24 2008-03-24
US7654808P 2008-06-27 2008-06-27
US18876508P 2008-08-11 2008-08-11
PCT/US2009/032743 WO2009134487A2 (en) 2008-01-31 2009-01-30 Optimized methods for delivery of dsrna targeting the pcsk9 gene

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JP2011511004A true JP2011511004A (ja) 2011-04-07
JP2011511004A5 JP2011511004A5 (https=) 2013-03-14

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JP2010545236A Pending JP2011511004A (ja) 2008-01-31 2009-01-30 ＰＣＳＫ９遺伝子を標的とするｄｓＲＮＡを送達するための最適化された方法

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US (2) US20100010066A1 (https=)
EP (1) EP2245039A4 (https=)
JP (1) JP2011511004A (https=)
AU (1) AU2009241591A1 (https=)
BR (1) BRPI0907008A2 (https=)
CA (1) CA2713379A1 (https=)
MX (1) MX2010008394A (https=)
WO (1) WO2009134487A2 (https=)

Cited By (6)

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JP2012530143A (ja) * 2009-06-15 2012-11-29 アルナイラム ファーマシューティカルズ， インコーポレイテッド Ｐｃｓｋ９遺伝子を標的とする、脂質で製剤化されたｄｓｒｎａ
KR20150003344A (ko) * 2012-04-26 2015-01-08 알닐람 파마슈티칼스 인코포레이티드 ＳＥＲＰＩＮＣ1 ｉＲＮＡ 조성물 및 그의 이용 방법
KR20150013159A (ko) * 2012-04-10 2015-02-04 알닐람 파마슈티칼스 인코포레이티드 Ａｌａｓ1 유전자의 발현을 억제하기 위한 조성물 및 방법
JP2016506240A (ja) * 2012-12-05 2016-03-03 アルナイラム ファーマシューティカルズ， インコーポレイテッドＡｌｎｙｌａｍ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． ＰＣＳＫ９ｉＲＮＡ組成物及びその使用方法
JP2016523094A (ja) * 2013-06-27 2016-08-08 ロシュ イノベーション センター コペンハーゲン エーエス Ｐｃｓｋ９を標的とするアンチセンスオリゴマーおよびコンジュゲート
WO2024248146A1 (ja) * 2023-05-31 2024-12-05 国立大学法人北海道大学 ｐＨ感受性カチオン性脂質及び脂質ナノ粒子

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