JP2011507857A - 線維症性の状態の処置のためのコネキシン４３の阻害剤の使用 - Google Patents

線維症性の状態の処置のためのコネキシン４３の阻害剤の使用 Download PDF

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JP2011507857A
JP2011507857A JP2010539513A JP2010539513A JP2011507857A JP 2011507857 A JP2011507857 A JP 2011507857A JP 2010539513 A JP2010539513 A JP 2010539513A JP 2010539513 A JP2010539513 A JP 2010539513A JP 2011507857 A JP2011507857 A JP 2011507857A
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connexin
fibrosis
polynucleotide
tissue
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デイビッド エル． ベッカー，
コリン アール． グリーン，
ブラッドフォード ジェイ． ダフト，
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コーダ セラピューティクス， インコーポレイテッド
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    • C—CHEMISTRY; METALLURGY
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/42—Use of materials characterised by their function or physical properties
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    • A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0061—Use of materials characterised by their function or physical properties
    • A61L26/0066—Medicaments; Biocides
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    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
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    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
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    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
    • A61L2300/258—Genetic materials, DNA, RNA, genes, vectors, e.g. plasmids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/432—Inhibitors, antagonists
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    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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JP2010539513A 2007-12-21 2008-12-22 線維症性の状態の処置のためのコネキシン４３の阻害剤の使用 Pending JP2011507857A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US879507P 2007-12-21 2007-12-21
PCT/US2008/014021 WO2009085270A2 (en) 2007-12-21 2008-12-22 Use of inhibitors of c0nnexin43 for treatment of fibrotic conditions

Publications (2)

Publication Number Publication Date
JP2011507857A true JP2011507857A (ja) 2011-03-10
JP2011507857A5 JP2011507857A5 (https=) 2013-04-25

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JP2010539513A Pending JP2011507857A (ja) 2007-12-21 2008-12-22 線維症性の状態の処置のためのコネキシン４３の阻害剤の使用

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US (2) US8975237B2 (https=)
EP (1) EP2237786A2 (https=)
JP (1) JP2011507857A (https=)
AU (1) AU2008343841A1 (https=)
CA (1) CA2710380A1 (https=)
WO (1) WO2009085270A2 (https=)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK1959981T3 (da) 2005-02-03 2020-01-27 Coda Therapeutics Ltd Anti-connexin 43 forbindelser til behandling af kroniske sår
US8975237B2 (en) 2007-12-21 2015-03-10 Coda Therapeutics, Inc. Treatment of fibrotic conditions
US20110275574A1 (en) * 2009-01-16 2011-11-10 Agency For Science, Technology And Research Method of inhibiting proliferation of hepatic stellate cells
US20130095169A1 (en) * 2010-04-28 2013-04-18 Allegheny-Singer Research Institute Compositions and Methods for Reduced Scarring and for Treatment of Fibrosis
GB201119089D0 (en) * 2011-11-04 2011-12-21 Isis Innovation Treatment of musculoskeletal fibroproliferative disorders
CA2866115C (en) 2012-03-01 2020-03-24 Firststring Research, Inc. Topical gels containing alpha connexin c-terminal (act) peptides
CA2868534A1 (en) 2012-03-27 2013-10-03 Coda Therapeutics, Inc. Compositions and treatments based on cadherin modulation
US10036015B2 (en) 2013-01-04 2018-07-31 Sandeep Kathju Composition and methods for reduced scarring and treatment of fibrosis
US10465188B2 (en) 2014-08-22 2019-11-05 Auckland Uniservices Limited Channel modulators
EP3439676B1 (en) 2016-04-04 2021-06-09 Omeza LLC Fish oil topical composition
CN111201247A (zh) 2017-04-28 2020-05-26 奥克兰联合服务有限公司 治疗方法和新颖构建体
MX2020008473A (es) * 2020-08-12 2022-02-14 Aspid S A De C V Uso de colageno-polivinilpirrolidona en la inflamacion y fibrosis pulmonar en pacientes infectados por el virus sars-cov2 (covid-19).
JP2023546757A (ja) 2020-10-22 2023-11-07 シークエル・バイオ・インコーポレイテッド ペプチド製剤および眼科におけるその使用

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002535377A (ja) * 1999-01-27 2002-10-22 ユニバーシテイ・カレツジ・ロンドン コネキシンに対するアンチセンスヌクレオチドを含む配合物
US20050119211A1 (en) * 2001-05-18 2005-06-02 Sirna Therapeutics, Inc. RNA mediated inhibition connexin gene expression using short interfering nucleic acid (siNA)
WO2006136694A1 (fr) * 2005-06-23 2006-12-28 1/4 Vin Moyen d'inertage a faible vitesse et dispositif mettant en œuvre ce moyen d'inertage pour conditionner un produit alimentaire
JP2010510225A (ja) * 2006-11-15 2010-04-02 コーダ セラピューティクス， インコーポレイテッド 創傷治癒のための改善された方法および組成物

Family Cites Families (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3687808A (en) * 1969-08-14 1972-08-29 Univ Leland Stanford Junior Synthetic polynucleotides
US5034506A (en) * 1985-03-15 1991-07-23 Anti-Gene Development Group Uncharged morpholino-based polymers having achiral intersubunit linkages
US4861757A (en) * 1986-11-14 1989-08-29 Institute Of Molecular Biology Wound healing and bone regeneration using PDGF and IGF-I
JPH0539594Y2 (https=) * 1988-08-05 1993-10-07
US5166195A (en) * 1990-05-11 1992-11-24 Isis Pharmaceuticals, Inc. Antisense inhibitors of the human immunodeficiency virus phosphorothioate oligonucleotides
GB9425930D0 (en) 1994-12-22 1995-02-22 Procter & Gamble Silicone compositions
US20030148968A1 (en) * 1995-02-28 2003-08-07 Hammond H. Kirk Techniques and compositions for treating cardiovascular disease by in vivo gene delivery
US6752987B1 (en) * 1995-02-28 2004-06-22 The Regents Of The University Of California Adenovirus encoding human adenylylcyclase (AC) VI
JP2001505432A (ja) 1996-12-02 2001-04-24 ダイヤド ファーマシューティカル コーポレイション ヒト接着分子のアンチセンス阻害
AU9016898A (en) * 1997-08-07 1999-03-01 United States Of America, Represented By The Secretary, Department Of Health And Human Services, The Methods and compositions for treatment of restenosis
EP1037981A1 (en) * 1997-12-09 2000-09-27 Children's Medical Center Corporation Soluble inhibitors of vascular endothelial growth factor and use thereof
US6506559B1 (en) * 1997-12-23 2003-01-14 Carnegie Institute Of Washington Genetic inhibition by double-stranded RNA
US5998148A (en) * 1999-04-08 1999-12-07 Isis Pharmaceuticals Inc. Antisense modulation of microtubule-associated protein 4 expression
JP2004531461A (ja) * 2000-10-18 2004-10-14 チルドレンズ メディカル センター コーポレーション オステオポンチン被覆表面および使用方法
WO2003032964A2 (en) 2001-10-17 2003-04-24 University Of Wales College Of Medecine Gap junctions and endothelial-derived hyperpolarizing factor (edhf)
HRP20040784A2 (en) * 2002-01-29 2005-04-30 Wyeth Compositions and methods for modulating connexin hemichannels
JP2005527209A (ja) 2002-04-22 2005-09-15 ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー 疼痛管理のためのプロテインキナーゼＣγのペプチドインヒビター
WO2003096981A2 (en) * 2002-05-15 2003-11-27 Seul, Kyung, Hwan Method of modulating angiogenesis
US8809504B2 (en) * 2002-09-03 2014-08-19 Vit Lauermann Inhibitor which is deactivatable by a reagent produced by a target cell
WO2006006948A2 (en) * 2002-11-14 2006-01-19 Dharmacon, Inc. METHODS AND COMPOSITIONS FOR SELECTING siRNA OF IMPROVED FUNCTIONALITY
EP1514929A1 (en) 2003-09-12 2005-03-16 Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts Antisense oligonucleotides for prevention of metastasis formation of cancer cells
CA3059497A1 (en) 2003-12-03 2005-06-16 Ocunexus Therapeutics, Inc. Antisense compounds targeted to connexins and methods of use thereof
SG158153A1 (en) 2004-12-21 2010-01-29 Musc Found For Res Dev Compositions and methods for promoting wound healing and tissue regeneration
DK1959981T3 (da) * 2005-02-03 2020-01-27 Coda Therapeutics Ltd Anti-connexin 43 forbindelser til behandling af kroniske sår
EA200870058A1 (ru) * 2005-12-16 2008-12-30 Арла Фудс Амба Композиции, содержащие остеопонтин крупного рогатого скота, для улучшения процесса заживления ран
AU2007254159B2 (en) 2006-05-19 2013-07-04 Mako Surgical Corp. System and method for verifying calibration of a surgical device
CN101835476B (zh) 2006-12-11 2016-08-17 科达治疗公司 作为受损伤口愈合组合物的抗连接蛋白多核苷酸
EP2114422A1 (en) * 2007-03-02 2009-11-11 National University of Ireland, Galway Osteopontin for the prediction and treatment of cardiovascular diseases
CN101765423B (zh) 2007-05-31 2014-08-06 安特里奥公司 核酸纳米粒子和其用途
EP2245158A2 (en) 2007-12-11 2010-11-03 Coda Therapeutics, Inc. Impaired wound healing compositions and treatments
US20110300130A1 (en) 2007-12-11 2011-12-08 Becker David L Impaired wound healing compositions and treatments
AU2008343839A1 (en) 2007-12-21 2009-07-09 Coda Therapeutics, Inc. Use of anti-connexin peptides, alone or in combination with anti-connexin polynucleotides, for the treatment of surgical adhesions
CA2710232A1 (en) 2007-12-21 2009-07-09 Coda Therapeutics, Inc. Treatment of abnormal or excessive scars
US20110144182A1 (en) 2007-12-21 2011-06-16 David Lawrence Becker Treatment of surgical adhesions
AU2008343758A1 (en) 2007-12-21 2009-07-09 Coda Therapeutics, Inc. Use of anti-connexin 43 polynucleotides for the treatment of abnormal or excessive scars
US20110243964A1 (en) 2007-12-21 2011-10-06 Bradford James Duft Treatment of orthopedic conditions
US8975237B2 (en) 2007-12-21 2015-03-10 Coda Therapeutics, Inc. Treatment of fibrotic conditions
CA2710375A1 (en) 2007-12-21 2009-07-09 Coda Therapeutics, Inc. Treatment of orthopedic conditions
JP2011507599A (ja) 2007-12-21 2011-03-10 コーダ セラピューティクス， インコーポレイテッド 改良医療デバイス
JP2011507861A (ja) 2007-12-21 2011-03-10 コーダ セラピューティクス， インコーポレイテッド 線維症性の状態の治療のための抗コネキシンポリヌクレオチド剤と組み合わせた抗コネキシンポリペプチド剤の使用
US20110038920A1 (en) 2008-01-07 2011-02-17 Ryoichi Mori Wound healing compositions and treatments
US20110223204A1 (en) 2008-06-04 2011-09-15 Bradford J Duft Treatment of pain with gap junction modulation compounds

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002535377A (ja) * 1999-01-27 2002-10-22 ユニバーシテイ・カレツジ・ロンドン コネキシンに対するアンチセンスヌクレオチドを含む配合物
US20050119211A1 (en) * 2001-05-18 2005-06-02 Sirna Therapeutics, Inc. RNA mediated inhibition connexin gene expression using short interfering nucleic acid (siNA)
WO2006136694A1 (fr) * 2005-06-23 2006-12-28 1/4 Vin Moyen d'inertage a faible vitesse et dispositif mettant en œuvre ce moyen d'inertage pour conditionner un produit alimentaire
JP2010510225A (ja) * 2006-11-15 2010-04-02 コーダ セラピューティクス， インコーポレイテッド 創傷治癒のための改善された方法および組成物

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
JPN6013041332; ＱＩＵ，Ｃ．　ｅｔ　ａｌ: Ｃｕｒｒｅｎｔ　Ｂｉｏｌｏｇｙ Ｖｏｌ．１３, 2003, ｐ．１６９７-１７０３ *
JPN6013041334; ＭＯＲＩ，Ｒ．　ｅｔ　ａｌ: Ｊｏｕｒｎａｌ　ｏｆ　Ｃｅｌｌ　Ｓｃｉｅｎｃｅ Ｖｏｌ．１１９, 2006, ｐ．５１９３-５２０３ *

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US8975237B2 (en) 2015-03-10
EP2237786A2 (en) 2010-10-13
AU2008343841A1 (en) 2009-07-09
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