JP2011507857A5 - - Google Patents
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- JP2011507857A5 JP2011507857A5 JP2010539513A JP2010539513A JP2011507857A5 JP 2011507857 A5 JP2011507857 A5 JP 2011507857A5 JP 2010539513 A JP2010539513 A JP 2010539513A JP 2010539513 A JP2010539513 A JP 2010539513A JP 2011507857 A5 JP2011507857 A5 JP 2011507857A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- fibrosis
- connexin
- polynucleotide
- tissue
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000000034 method Methods 0.000 claims description 46
- 239000000203 mixture Substances 0.000 claims description 43
- 108091033319 polynucleotide Proteins 0.000 claims description 35
- 102000040430 polynucleotide Human genes 0.000 claims description 35
- 239000002157 polynucleotide Substances 0.000 claims description 35
- 206010016654 Fibrosis Diseases 0.000 claims description 22
- 230000004761 fibrosis Effects 0.000 claims description 22
- 210000001519 tissue Anatomy 0.000 claims description 21
- 208000006111 contracture Diseases 0.000 claims description 16
- 206010062575 Muscle contracture Diseases 0.000 claims description 13
- 108091034117 Oligonucleotide Proteins 0.000 claims description 12
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 10
- 102000001045 Connexin 43 Human genes 0.000 claims description 8
- 108010069241 Connexin 43 Proteins 0.000 claims description 8
- 208000005069 pulmonary fibrosis Diseases 0.000 claims description 8
- 208000019425 cirrhosis of liver Diseases 0.000 claims description 6
- 201000010099 disease Diseases 0.000 claims description 5
- 208000035475 disorder Diseases 0.000 claims description 5
- 230000002265 prevention Effects 0.000 claims description 5
- 208000000185 Localized scleroderma Diseases 0.000 claims description 4
- 108091030071 RNAI Proteins 0.000 claims description 4
- 206010039710 Scleroderma Diseases 0.000 claims description 4
- 108020004459 Small interfering RNA Proteins 0.000 claims description 4
- 230000001154 acute effect Effects 0.000 claims description 4
- 230000003510 anti-fibrotic effect Effects 0.000 claims description 4
- 239000000074 antisense oligonucleotide Substances 0.000 claims description 4
- 238000012230 antisense oligonucleotides Methods 0.000 claims description 4
- 230000009787 cardiac fibrosis Effects 0.000 claims description 4
- 238000002512 chemotherapy Methods 0.000 claims description 4
- 230000009368 gene silencing by RNA Effects 0.000 claims description 4
- 206010061989 glomerulosclerosis Diseases 0.000 claims description 4
- 208000014674 injury Diseases 0.000 claims description 4
- 230000005855 radiation Effects 0.000 claims description 4
- 201000002793 renal fibrosis Diseases 0.000 claims description 4
- 231100000241 scar Toxicity 0.000 claims description 3
- 208000012260 Accidental injury Diseases 0.000 claims description 2
- 208000007848 Alcoholism Diseases 0.000 claims description 2
- 208000033116 Asbestos intoxication Diseases 0.000 claims description 2
- 102000012437 Copper-Transporting ATPases Human genes 0.000 claims description 2
- 208000011231 Crohn disease Diseases 0.000 claims description 2
- 208000032131 Diabetic Neuropathies Diseases 0.000 claims description 2
- 208000001708 Dupuytren contracture Diseases 0.000 claims description 2
- 206010014664 Endocardial fibrosis Diseases 0.000 claims description 2
- 206010014954 Eosinophilic fasciitis Diseases 0.000 claims description 2
- 208000018565 Hemochromatosis Diseases 0.000 claims description 2
- 206010019799 Hepatitis viral Diseases 0.000 claims description 2
- 208000002972 Hepatolenticular Degeneration Diseases 0.000 claims description 2
- 101000894966 Homo sapiens Gap junction alpha-1 protein Proteins 0.000 claims description 2
- 201000009794 Idiopathic Pulmonary Fibrosis Diseases 0.000 claims description 2
- 208000014919 IgG4-related retroperitoneal fibrosis Diseases 0.000 claims description 2
- 208000022559 Inflammatory bowel disease Diseases 0.000 claims description 2
- 208000029523 Interstitial Lung disease Diseases 0.000 claims description 2
- 208000001055 Ischemic Contracture Diseases 0.000 claims description 2
- 206010067125 Liver injury Diseases 0.000 claims description 2
- 206010027982 Morphoea Diseases 0.000 claims description 2
- 206010028594 Myocardial fibrosis Diseases 0.000 claims description 2
- 206010031023 Oral submucosal fibrosis Diseases 0.000 claims description 2
- 206010033645 Pancreatitis Diseases 0.000 claims description 2
- 206010038979 Retroperitoneal fibrosis Diseases 0.000 claims description 2
- 201000010001 Silicosis Diseases 0.000 claims description 2
- 201000000027 Volkmann contracture Diseases 0.000 claims description 2
- 208000018839 Wilson disease Diseases 0.000 claims description 2
- 208000027418 Wounds and injury Diseases 0.000 claims description 2
- 230000002159 abnormal effect Effects 0.000 claims description 2
- 201000007930 alcohol dependence Diseases 0.000 claims description 2
- 206010003441 asbestosis Diseases 0.000 claims description 2
- 210000005013 brain tissue Anatomy 0.000 claims description 2
- 231100000012 chronic liver injury Toxicity 0.000 claims description 2
- 230000006378 damage Effects 0.000 claims description 2
- 230000002068 genetic effect Effects 0.000 claims description 2
- 210000005003 heart tissue Anatomy 0.000 claims description 2
- 102000048481 human GJA1 Human genes 0.000 claims description 2
- 238000000338 in vitro Methods 0.000 claims description 2
- 238000001727 in vivo Methods 0.000 claims description 2
- 238000011065 in-situ storage Methods 0.000 claims description 2
- 208000015181 infectious disease Diseases 0.000 claims description 2
- 208000036971 interstitial lung disease 2 Diseases 0.000 claims description 2
- 208000017169 kidney disease Diseases 0.000 claims description 2
- 208000016809 linear scleroderma Diseases 0.000 claims description 2
- 210000005228 liver tissue Anatomy 0.000 claims description 2
- 210000004072 lung Anatomy 0.000 claims description 2
- 208000030159 metabolic disease Diseases 0.000 claims description 2
- 210000000944 nerve tissue Anatomy 0.000 claims description 2
- 206010065988 nodular fasciitis Diseases 0.000 claims description 2
- 208000005207 oral submucous fibrosis Diseases 0.000 claims description 2
- 208000030346 palmar fibromatosis Diseases 0.000 claims description 2
- 230000000750 progressive effect Effects 0.000 claims description 2
- 201000006081 pseudosarcomatous fibromatosis Diseases 0.000 claims description 2
- 210000005084 renal tissue Anatomy 0.000 claims description 2
- 230000002207 retinal effect Effects 0.000 claims description 2
- 201000004409 schistosomiasis Diseases 0.000 claims description 2
- 201000001862 viral hepatitis Diseases 0.000 claims description 2
- 206010056375 Bile duct obstruction Diseases 0.000 claims 1
- 206010008635 Cholestasis Diseases 0.000 claims 1
- 238000001959 radiotherapy Methods 0.000 claims 1
- 239000003053 toxin Substances 0.000 claims 1
- 231100000765 toxin Toxicity 0.000 claims 1
- 208000037999 tubulointerstitial fibrosis Diseases 0.000 claims 1
- 230000003176 fibrotic effect Effects 0.000 description 6
- 239000002552 dosage form Substances 0.000 description 5
- 230000000692 anti-sense effect Effects 0.000 description 3
- 102000010970 Connexin Human genes 0.000 description 2
- 108050001175 Connexin Proteins 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 239000005022 packaging material Substances 0.000 description 2
- 229940124597 therapeutic agent Drugs 0.000 description 2
- 230000000699 topical effect Effects 0.000 description 2
- 230000029663 wound healing Effects 0.000 description 2
- 231100000573 exposure to toxins Toxicity 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 230000037390 scarring Effects 0.000 description 1
- 230000004580 weight loss Effects 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US879507P | 2007-12-21 | 2007-12-21 | |
| PCT/US2008/014021 WO2009085270A2 (en) | 2007-12-21 | 2008-12-22 | Use of inhibitors of c0nnexin43 for treatment of fibrotic conditions |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2011507857A JP2011507857A (ja) | 2011-03-10 |
| JP2011507857A5 true JP2011507857A5 (https=) | 2013-04-25 |
Family
ID=40824955
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010539513A Pending JP2011507857A (ja) | 2007-12-21 | 2008-12-22 | 線維症性の状態の処置のためのコネキシン４３の阻害剤の使用 |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US8975237B2 (https=) |
| EP (1) | EP2237786A2 (https=) |
| JP (1) | JP2011507857A (https=) |
| AU (1) | AU2008343841A1 (https=) |
| CA (1) | CA2710380A1 (https=) |
| WO (1) | WO2009085270A2 (https=) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK1959981T3 (da) | 2005-02-03 | 2020-01-27 | Coda Therapeutics Ltd | Anti-connexin 43 forbindelser til behandling af kroniske sår |
| US8975237B2 (en) | 2007-12-21 | 2015-03-10 | Coda Therapeutics, Inc. | Treatment of fibrotic conditions |
| US20110275574A1 (en) * | 2009-01-16 | 2011-11-10 | Agency For Science, Technology And Research | Method of inhibiting proliferation of hepatic stellate cells |
| US20130095169A1 (en) * | 2010-04-28 | 2013-04-18 | Allegheny-Singer Research Institute | Compositions and Methods for Reduced Scarring and for Treatment of Fibrosis |
| GB201119089D0 (en) * | 2011-11-04 | 2011-12-21 | Isis Innovation | Treatment of musculoskeletal fibroproliferative disorders |
| CA2866115C (en) | 2012-03-01 | 2020-03-24 | Firststring Research, Inc. | Topical gels containing alpha connexin c-terminal (act) peptides |
| CA2868534A1 (en) | 2012-03-27 | 2013-10-03 | Coda Therapeutics, Inc. | Compositions and treatments based on cadherin modulation |
| US10036015B2 (en) | 2013-01-04 | 2018-07-31 | Sandeep Kathju | Composition and methods for reduced scarring and treatment of fibrosis |
| US10465188B2 (en) | 2014-08-22 | 2019-11-05 | Auckland Uniservices Limited | Channel modulators |
| EP3439676B1 (en) | 2016-04-04 | 2021-06-09 | Omeza LLC | Fish oil topical composition |
| CN111201247A (zh) | 2017-04-28 | 2020-05-26 | 奥克兰联合服务有限公司 | 治疗方法和新颖构建体 |
| MX2020008473A (es) * | 2020-08-12 | 2022-02-14 | Aspid S A De C V | Uso de colageno-polivinilpirrolidona en la inflamacion y fibrosis pulmonar en pacientes infectados por el virus sars-cov2 (covid-19). |
| JP2023546757A (ja) | 2020-10-22 | 2023-11-07 | シークエル・バイオ・インコーポレイテッド | ペプチド製剤および眼科におけるその使用 |
Family Cites Families (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3687808A (en) * | 1969-08-14 | 1972-08-29 | Univ Leland Stanford Junior | Synthetic polynucleotides |
| US5034506A (en) * | 1985-03-15 | 1991-07-23 | Anti-Gene Development Group | Uncharged morpholino-based polymers having achiral intersubunit linkages |
| US4861757A (en) * | 1986-11-14 | 1989-08-29 | Institute Of Molecular Biology | Wound healing and bone regeneration using PDGF and IGF-I |
| JPH0539594Y2 (https=) * | 1988-08-05 | 1993-10-07 | ||
| US5166195A (en) * | 1990-05-11 | 1992-11-24 | Isis Pharmaceuticals, Inc. | Antisense inhibitors of the human immunodeficiency virus phosphorothioate oligonucleotides |
| GB9425930D0 (en) | 1994-12-22 | 1995-02-22 | Procter & Gamble | Silicone compositions |
| US20030148968A1 (en) * | 1995-02-28 | 2003-08-07 | Hammond H. Kirk | Techniques and compositions for treating cardiovascular disease by in vivo gene delivery |
| US6752987B1 (en) * | 1995-02-28 | 2004-06-22 | The Regents Of The University Of California | Adenovirus encoding human adenylylcyclase (AC) VI |
| JP2001505432A (ja) | 1996-12-02 | 2001-04-24 | ダイヤド ファーマシューティカル コーポレイション | ヒト接着分子のアンチセンス阻害 |
| AU9016898A (en) * | 1997-08-07 | 1999-03-01 | United States Of America, Represented By The Secretary, Department Of Health And Human Services, The | Methods and compositions for treatment of restenosis |
| EP1037981A1 (en) * | 1997-12-09 | 2000-09-27 | Children's Medical Center Corporation | Soluble inhibitors of vascular endothelial growth factor and use thereof |
| US6506559B1 (en) * | 1997-12-23 | 2003-01-14 | Carnegie Institute Of Washington | Genetic inhibition by double-stranded RNA |
| DK1146908T3 (da) * | 1999-01-27 | 2005-10-10 | Becker David Dr | Formuleringer omfattende antisense-nukleotider mod connexiner |
| US5998148A (en) * | 1999-04-08 | 1999-12-07 | Isis Pharmaceuticals Inc. | Antisense modulation of microtubule-associated protein 4 expression |
| JP2004531461A (ja) * | 2000-10-18 | 2004-10-14 | チルドレンズ メディカル センター コーポレーション | オステオポンチン被覆表面および使用方法 |
| US20050119211A1 (en) * | 2001-05-18 | 2005-06-02 | Sirna Therapeutics, Inc. | RNA mediated inhibition connexin gene expression using short interfering nucleic acid (siNA) |
| WO2003032964A2 (en) | 2001-10-17 | 2003-04-24 | University Of Wales College Of Medecine | Gap junctions and endothelial-derived hyperpolarizing factor (edhf) |
| HRP20040784A2 (en) * | 2002-01-29 | 2005-04-30 | Wyeth | Compositions and methods for modulating connexin hemichannels |
| JP2005527209A (ja) | 2002-04-22 | 2005-09-15 | ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー | 疼痛管理のためのプロテインキナーゼＣγのペプチドインヒビター |
| WO2003096981A2 (en) * | 2002-05-15 | 2003-11-27 | Seul, Kyung, Hwan | Method of modulating angiogenesis |
| US8809504B2 (en) * | 2002-09-03 | 2014-08-19 | Vit Lauermann | Inhibitor which is deactivatable by a reagent produced by a target cell |
| WO2006006948A2 (en) * | 2002-11-14 | 2006-01-19 | Dharmacon, Inc. | METHODS AND COMPOSITIONS FOR SELECTING siRNA OF IMPROVED FUNCTIONALITY |
| EP1514929A1 (en) | 2003-09-12 | 2005-03-16 | Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts | Antisense oligonucleotides for prevention of metastasis formation of cancer cells |
| CA3059497A1 (en) | 2003-12-03 | 2005-06-16 | Ocunexus Therapeutics, Inc. | Antisense compounds targeted to connexins and methods of use thereof |
| SG158153A1 (en) | 2004-12-21 | 2010-01-29 | Musc Found For Res Dev | Compositions and methods for promoting wound healing and tissue regeneration |
| DK1959981T3 (da) * | 2005-02-03 | 2020-01-27 | Coda Therapeutics Ltd | Anti-connexin 43 forbindelser til behandling af kroniske sår |
| FR2887524A1 (fr) * | 2005-06-23 | 2006-12-29 | 1 4 Vin Sarl | Moyen d'inertage a faible vitesse et dispositif mettant en oeuvre ce moyen d'inertage pour conditionner un produit alimentaire |
| EA200870058A1 (ru) * | 2005-12-16 | 2008-12-30 | Арла Фудс Амба | Композиции, содержащие остеопонтин крупного рогатого скота, для улучшения процесса заживления ран |
| AU2007254159B2 (en) | 2006-05-19 | 2013-07-04 | Mako Surgical Corp. | System and method for verifying calibration of a surgical device |
| EP2091557A2 (en) * | 2006-11-15 | 2009-08-26 | Coda Therapeutics, INC. | Improved methods and compositions for wound healing |
| CN101835476B (zh) | 2006-12-11 | 2016-08-17 | 科达治疗公司 | 作为受损伤口愈合组合物的抗连接蛋白多核苷酸 |
| EP2114422A1 (en) * | 2007-03-02 | 2009-11-11 | National University of Ireland, Galway | Osteopontin for the prediction and treatment of cardiovascular diseases |
| CN101765423B (zh) | 2007-05-31 | 2014-08-06 | 安特里奥公司 | 核酸纳米粒子和其用途 |
| EP2245158A2 (en) | 2007-12-11 | 2010-11-03 | Coda Therapeutics, Inc. | Impaired wound healing compositions and treatments |
| US20110300130A1 (en) | 2007-12-11 | 2011-12-08 | Becker David L | Impaired wound healing compositions and treatments |
| AU2008343839A1 (en) | 2007-12-21 | 2009-07-09 | Coda Therapeutics, Inc. | Use of anti-connexin peptides, alone or in combination with anti-connexin polynucleotides, for the treatment of surgical adhesions |
| CA2710232A1 (en) | 2007-12-21 | 2009-07-09 | Coda Therapeutics, Inc. | Treatment of abnormal or excessive scars |
| US20110144182A1 (en) | 2007-12-21 | 2011-06-16 | David Lawrence Becker | Treatment of surgical adhesions |
| AU2008343758A1 (en) | 2007-12-21 | 2009-07-09 | Coda Therapeutics, Inc. | Use of anti-connexin 43 polynucleotides for the treatment of abnormal or excessive scars |
| US20110243964A1 (en) | 2007-12-21 | 2011-10-06 | Bradford James Duft | Treatment of orthopedic conditions |
| US8975237B2 (en) | 2007-12-21 | 2015-03-10 | Coda Therapeutics, Inc. | Treatment of fibrotic conditions |
| CA2710375A1 (en) | 2007-12-21 | 2009-07-09 | Coda Therapeutics, Inc. | Treatment of orthopedic conditions |
| JP2011507599A (ja) | 2007-12-21 | 2011-03-10 | コーダ セラピューティクス， インコーポレイテッド | 改良医療デバイス |
| JP2011507861A (ja) | 2007-12-21 | 2011-03-10 | コーダ セラピューティクス， インコーポレイテッド | 線維症性の状態の治療のための抗コネキシンポリヌクレオチド剤と組み合わせた抗コネキシンポリペプチド剤の使用 |
| US20110038920A1 (en) | 2008-01-07 | 2011-02-17 | Ryoichi Mori | Wound healing compositions and treatments |
| US20110223204A1 (en) | 2008-06-04 | 2011-09-15 | Bradford J Duft | Treatment of pain with gap junction modulation compounds |
-
2008
- 2008-12-22 US US12/809,886 patent/US8975237B2/en not_active Expired - Fee Related
- 2008-12-22 CA CA2710380A patent/CA2710380A1/en not_active Abandoned
- 2008-12-22 WO PCT/US2008/014021 patent/WO2009085270A2/en not_active Ceased
- 2008-12-22 AU AU2008343841A patent/AU2008343841A1/en not_active Abandoned
- 2008-12-22 EP EP08866327A patent/EP2237786A2/en not_active Withdrawn
- 2008-12-22 JP JP2010539513A patent/JP2011507857A/ja active Pending
-
2015
- 2015-03-09 US US14/642,582 patent/US9738892B2/en active Active
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