JP2011507857A5 - - Google Patents
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- Publication number
- JP2011507857A5 JP2011507857A5 JP2010539513A JP2010539513A JP2011507857A5 JP 2011507857 A5 JP2011507857 A5 JP 2011507857A5 JP 2010539513 A JP2010539513 A JP 2010539513A JP 2010539513 A JP2010539513 A JP 2010539513A JP 2011507857 A5 JP2011507857 A5 JP 2011507857A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- fibrosis
- connexin
- polynucleotide
- tissue
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000000034 method Methods 0.000 claims description 46
- 239000000203 mixture Substances 0.000 claims description 43
- 108091033319 polynucleotide Proteins 0.000 claims description 35
- 102000040430 polynucleotide Human genes 0.000 claims description 35
- 239000002157 polynucleotide Substances 0.000 claims description 35
- 206010016654 Fibrosis Diseases 0.000 claims description 22
- 230000004761 fibrosis Effects 0.000 claims description 22
- 210000001519 tissue Anatomy 0.000 claims description 21
- 208000006111 contracture Diseases 0.000 claims description 16
- 206010062575 Muscle contracture Diseases 0.000 claims description 13
- 108091034117 Oligonucleotide Proteins 0.000 claims description 12
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 10
- 102000001045 Connexin 43 Human genes 0.000 claims description 8
- 108010069241 Connexin 43 Proteins 0.000 claims description 8
- 208000005069 pulmonary fibrosis Diseases 0.000 claims description 8
- 208000019425 cirrhosis of liver Diseases 0.000 claims description 6
- 201000010099 disease Diseases 0.000 claims description 5
- 208000035475 disorder Diseases 0.000 claims description 5
- 230000002265 prevention Effects 0.000 claims description 5
- 208000000185 Localized scleroderma Diseases 0.000 claims description 4
- 108091030071 RNAI Proteins 0.000 claims description 4
- 206010039710 Scleroderma Diseases 0.000 claims description 4
- 108020004459 Small interfering RNA Proteins 0.000 claims description 4
- 230000001154 acute effect Effects 0.000 claims description 4
- 230000003510 anti-fibrotic effect Effects 0.000 claims description 4
- 239000000074 antisense oligonucleotide Substances 0.000 claims description 4
- 238000012230 antisense oligonucleotides Methods 0.000 claims description 4
- 230000009787 cardiac fibrosis Effects 0.000 claims description 4
- 238000002512 chemotherapy Methods 0.000 claims description 4
- 230000009368 gene silencing by RNA Effects 0.000 claims description 4
- 206010061989 glomerulosclerosis Diseases 0.000 claims description 4
- 208000014674 injury Diseases 0.000 claims description 4
- 230000005855 radiation Effects 0.000 claims description 4
- 201000002793 renal fibrosis Diseases 0.000 claims description 4
- 231100000241 scar Toxicity 0.000 claims description 3
- 208000012260 Accidental injury Diseases 0.000 claims description 2
- 208000007848 Alcoholism Diseases 0.000 claims description 2
- 208000033116 Asbestos intoxication Diseases 0.000 claims description 2
- 102000012437 Copper-Transporting ATPases Human genes 0.000 claims description 2
- 208000011231 Crohn disease Diseases 0.000 claims description 2
- 208000032131 Diabetic Neuropathies Diseases 0.000 claims description 2
- 208000001708 Dupuytren contracture Diseases 0.000 claims description 2
- 206010014664 Endocardial fibrosis Diseases 0.000 claims description 2
- 206010014954 Eosinophilic fasciitis Diseases 0.000 claims description 2
- 208000018565 Hemochromatosis Diseases 0.000 claims description 2
- 206010019799 Hepatitis viral Diseases 0.000 claims description 2
- 208000002972 Hepatolenticular Degeneration Diseases 0.000 claims description 2
- 101000894966 Homo sapiens Gap junction alpha-1 protein Proteins 0.000 claims description 2
- 201000009794 Idiopathic Pulmonary Fibrosis Diseases 0.000 claims description 2
- 208000014919 IgG4-related retroperitoneal fibrosis Diseases 0.000 claims description 2
- 208000022559 Inflammatory bowel disease Diseases 0.000 claims description 2
- 208000029523 Interstitial Lung disease Diseases 0.000 claims description 2
- 208000001055 Ischemic Contracture Diseases 0.000 claims description 2
- 206010067125 Liver injury Diseases 0.000 claims description 2
- 206010027982 Morphoea Diseases 0.000 claims description 2
- 206010028594 Myocardial fibrosis Diseases 0.000 claims description 2
- 206010031023 Oral submucosal fibrosis Diseases 0.000 claims description 2
- 206010033645 Pancreatitis Diseases 0.000 claims description 2
- 206010038979 Retroperitoneal fibrosis Diseases 0.000 claims description 2
- 201000010001 Silicosis Diseases 0.000 claims description 2
- 201000000027 Volkmann contracture Diseases 0.000 claims description 2
- 208000018839 Wilson disease Diseases 0.000 claims description 2
- 208000027418 Wounds and injury Diseases 0.000 claims description 2
- 230000002159 abnormal effect Effects 0.000 claims description 2
- 201000007930 alcohol dependence Diseases 0.000 claims description 2
- 206010003441 asbestosis Diseases 0.000 claims description 2
- 210000005013 brain tissue Anatomy 0.000 claims description 2
- 231100000012 chronic liver injury Toxicity 0.000 claims description 2
- 230000006378 damage Effects 0.000 claims description 2
- 230000002068 genetic effect Effects 0.000 claims description 2
- 210000005003 heart tissue Anatomy 0.000 claims description 2
- 102000048481 human GJA1 Human genes 0.000 claims description 2
- 238000000338 in vitro Methods 0.000 claims description 2
- 238000001727 in vivo Methods 0.000 claims description 2
- 238000011065 in-situ storage Methods 0.000 claims description 2
- 208000015181 infectious disease Diseases 0.000 claims description 2
- 208000036971 interstitial lung disease 2 Diseases 0.000 claims description 2
- 208000017169 kidney disease Diseases 0.000 claims description 2
- 208000016809 linear scleroderma Diseases 0.000 claims description 2
- 210000005228 liver tissue Anatomy 0.000 claims description 2
- 210000004072 lung Anatomy 0.000 claims description 2
- 208000030159 metabolic disease Diseases 0.000 claims description 2
- 210000000944 nerve tissue Anatomy 0.000 claims description 2
- 206010065988 nodular fasciitis Diseases 0.000 claims description 2
- 208000005207 oral submucous fibrosis Diseases 0.000 claims description 2
- 208000030346 palmar fibromatosis Diseases 0.000 claims description 2
- 230000000750 progressive effect Effects 0.000 claims description 2
- 201000006081 pseudosarcomatous fibromatosis Diseases 0.000 claims description 2
- 210000005084 renal tissue Anatomy 0.000 claims description 2
- 230000002207 retinal effect Effects 0.000 claims description 2
- 201000004409 schistosomiasis Diseases 0.000 claims description 2
- 201000001862 viral hepatitis Diseases 0.000 claims description 2
- 206010056375 Bile duct obstruction Diseases 0.000 claims 1
- 206010008635 Cholestasis Diseases 0.000 claims 1
- 238000001959 radiotherapy Methods 0.000 claims 1
- 239000003053 toxin Substances 0.000 claims 1
- 231100000765 toxin Toxicity 0.000 claims 1
- 208000037999 tubulointerstitial fibrosis Diseases 0.000 claims 1
- 230000003176 fibrotic effect Effects 0.000 description 6
- 239000002552 dosage form Substances 0.000 description 5
- 230000000692 anti-sense effect Effects 0.000 description 3
- 102000010970 Connexin Human genes 0.000 description 2
- 108050001175 Connexin Proteins 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 239000005022 packaging material Substances 0.000 description 2
- 229940124597 therapeutic agent Drugs 0.000 description 2
- 230000000699 topical effect Effects 0.000 description 2
- 230000029663 wound healing Effects 0.000 description 2
- 231100000573 exposure to toxins Toxicity 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 230000037390 scarring Effects 0.000 description 1
- 230000004580 weight loss Effects 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US879507P | 2007-12-21 | 2007-12-21 | |
| PCT/US2008/014021 WO2009085270A2 (en) | 2007-12-21 | 2008-12-22 | Use of inhibitors of c0nnexin43 for treatment of fibrotic conditions |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2011507857A JP2011507857A (ja) | 2011-03-10 |
| JP2011507857A5 true JP2011507857A5 (https=) | 2013-04-25 |
Family
ID=40824955
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010539513A Pending JP2011507857A (ja) | 2007-12-21 | 2008-12-22 | 線維症性の状態の処置のためのコネキシン４３の阻害剤の使用 |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US8975237B2 (https=) |
| EP (1) | EP2237786A2 (https=) |
| JP (1) | JP2011507857A (https=) |
| AU (1) | AU2008343841A1 (https=) |
| CA (1) | CA2710380A1 (https=) |
| WO (1) | WO2009085270A2 (https=) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102073629B1 (ko) | 2005-02-03 | 2020-02-05 | 코다 테라퓨틱스 (엔지) 리미티드 | 항-코넥신 화합물 및 그의 용도 |
| US8975237B2 (en) | 2007-12-21 | 2015-03-10 | Coda Therapeutics, Inc. | Treatment of fibrotic conditions |
| CN102405287A (zh) * | 2009-01-16 | 2012-04-04 | 新加坡科技研究局 | 抑制肝星状细胞增殖的方法 |
| WO2011139846A2 (en) * | 2010-04-28 | 2011-11-10 | Allegheny-Singer Research Institute | Compositions and methods for reduced scarring and for treatment of fibrosis |
| GB201119089D0 (en) * | 2011-11-04 | 2011-12-21 | Isis Innovation | Treatment of musculoskeletal fibroproliferative disorders |
| DK2819682T3 (en) | 2012-03-01 | 2017-08-21 | Firststring Res Inc | TOPICAL GELLS CONTAINING ALPHA-CONNEXIN C-TERMINAL (ACT) PEPTIDES |
| WO2013148736A1 (en) | 2012-03-27 | 2013-10-03 | Coda Therapeutics, Inc. | Compositions and treatments based on cadherin modulation |
| US10036015B2 (en) | 2013-01-04 | 2018-07-31 | Sandeep Kathju | Composition and methods for reduced scarring and treatment of fibrosis |
| CN107109410B (zh) | 2014-08-22 | 2021-11-02 | 奥克兰联合服务有限公司 | 通道调节剂 |
| CN109219442A (zh) | 2016-04-04 | 2019-01-15 | Omeza有限公司 | 鱼油局部组合物 |
| CA3061738A1 (en) | 2017-04-28 | 2018-11-01 | Auckland Uniservices Limited | Methods of treatment and novel constructs |
| MX2020008473A (es) * | 2020-08-12 | 2022-02-14 | Aspid S A De C V | Uso de colageno-polivinilpirrolidona en la inflamacion y fibrosis pulmonar en pacientes infectados por el virus sars-cov2 (covid-19). |
| MX2023004631A (es) | 2020-10-22 | 2023-07-20 | Xequel Bio Inc | Formulaciones peptidicas y usos oftalmicos de las mismas. |
Family Cites Families (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3687808A (en) * | 1969-08-14 | 1972-08-29 | Univ Leland Stanford Junior | Synthetic polynucleotides |
| US5034506A (en) * | 1985-03-15 | 1991-07-23 | Anti-Gene Development Group | Uncharged morpholino-based polymers having achiral intersubunit linkages |
| CA1322714C (en) * | 1986-11-14 | 1993-10-05 | Harry N. Antoniades | Wound healing and bone regeneration |
| JPH0539594Y2 (https=) * | 1988-08-05 | 1993-10-07 | ||
| US5166195A (en) * | 1990-05-11 | 1992-11-24 | Isis Pharmaceuticals, Inc. | Antisense inhibitors of the human immunodeficiency virus phosphorothioate oligonucleotides |
| GB9425930D0 (en) | 1994-12-22 | 1995-02-22 | Procter & Gamble | Silicone compositions |
| US20030148968A1 (en) * | 1995-02-28 | 2003-08-07 | Hammond H. Kirk | Techniques and compositions for treating cardiovascular disease by in vivo gene delivery |
| US6752987B1 (en) * | 1995-02-28 | 2004-06-22 | The Regents Of The University Of California | Adenovirus encoding human adenylylcyclase (AC) VI |
| EP0950060A4 (en) | 1996-12-02 | 2000-07-05 | Dyad Pharmaceutical Corp | COUNTERSTRAIN INHIBITION OF HUMAN ADHESION MOLECULES |
| AU9016898A (en) * | 1997-08-07 | 1999-03-01 | United States Of America, Represented By The Secretary, Department Of Health And Human Services, The | Methods and compositions for treatment of restenosis |
| WO1999029858A1 (en) * | 1997-12-09 | 1999-06-17 | Children's Medical Center Corporation | Soluble inhibitors of vascular endothelial growth factor and use thereof |
| US6506559B1 (en) * | 1997-12-23 | 2003-01-14 | Carnegie Institute Of Washington | Genetic inhibition by double-stranded RNA |
| EP2314321B1 (en) * | 1999-01-27 | 2014-06-04 | Coda Therapeutics, Inc. | Formulations comprising antisense nucleotides to connexins |
| US5998148A (en) * | 1999-04-08 | 1999-12-07 | Isis Pharmaceuticals Inc. | Antisense modulation of microtubule-associated protein 4 expression |
| CA2425662A1 (en) * | 2000-10-18 | 2002-04-25 | Children's Medical Center Corporation | Osteopontin-coated surfaces and methods of use |
| US20050119211A1 (en) * | 2001-05-18 | 2005-06-02 | Sirna Therapeutics, Inc. | RNA mediated inhibition connexin gene expression using short interfering nucleic acid (siNA) |
| JP2005509621A (ja) * | 2001-10-17 | 2005-04-14 | ユニバーシティ オブ ウェールズ カレッジ オブ メディスン | ギャップ結合ならびにｅｄｈｆ |
| CN1638790A (zh) * | 2002-01-29 | 2005-07-13 | Wyeth公司 | 用于调节连接蛋白半通道的组合物和方法 |
| AU2003234185C1 (en) | 2002-04-22 | 2009-11-19 | The Board Of Trustees Of The Leland Stanford Junior University | Peptide inhibitors of protein kinase C |
| WO2003096981A2 (en) * | 2002-05-15 | 2003-11-27 | Seul, Kyung, Hwan | Method of modulating angiogenesis |
| US8809504B2 (en) * | 2002-09-03 | 2014-08-19 | Vit Lauermann | Inhibitor which is deactivatable by a reagent produced by a target cell |
| WO2006006948A2 (en) * | 2002-11-14 | 2006-01-19 | Dharmacon, Inc. | METHODS AND COMPOSITIONS FOR SELECTING siRNA OF IMPROVED FUNCTIONALITY |
| EP1514929A1 (en) | 2003-09-12 | 2005-03-16 | Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts | Antisense oligonucleotides for prevention of metastasis formation of cancer cells |
| KR101350837B1 (ko) | 2003-12-03 | 2014-01-14 | 코다 테라퓨틱스, 인크. | 코넥신에 표적화된 안티센스 화합물 및 그의 사용 방법 |
| RU2438696C2 (ru) | 2004-12-21 | 2012-01-10 | Маск Фаундейшн Фор Рисерч Дивелопмент | Композиции и способы, используемые для ускорения заживления ран и регенерации тканей |
| KR102073629B1 (ko) | 2005-02-03 | 2020-02-05 | 코다 테라퓨틱스 (엔지) 리미티드 | 항-코넥신 화합물 및 그의 용도 |
| FR2887524A1 (fr) * | 2005-06-23 | 2006-12-29 | 1 4 Vin Sarl | Moyen d'inertage a faible vitesse et dispositif mettant en oeuvre ce moyen d'inertage pour conditionner un produit alimentaire |
| KR20080088600A (ko) * | 2005-12-16 | 2008-10-02 | 아를라 푸즈 에이엠비에이 | 상처 치유 방법의 개선을 위한 소 오스테오폰틴 제제 |
| CA2654261C (en) | 2006-05-19 | 2017-05-16 | Mako Surgical Corp. | Method and apparatus for controlling a haptic device |
| AU2007319811A1 (en) * | 2006-11-15 | 2008-05-22 | Coda Therapeutics, Inc. | Improved methods and compositions for wound healing |
| EP2543377A1 (en) | 2006-12-11 | 2013-01-09 | Coda Therapeutics, INC. | Anticonnexin polynucleotides as impaired wound healing compositions |
| AU2008223817A1 (en) * | 2007-03-02 | 2008-09-12 | National University Of Ireland, Galway | Osteopontin for the prediction and treatment of cardiovascular diseases |
| WO2008151022A2 (en) | 2007-05-31 | 2008-12-11 | Anterios, Inc. | Nucleic acid nanoparticles and uses therefor |
| WO2009075881A2 (en) | 2007-12-11 | 2009-06-18 | Coda Therapeutics, Inc. | Impaired wound healing compositions and treatments |
| EP2245158A2 (en) | 2007-12-11 | 2010-11-03 | Coda Therapeutics, Inc. | Impaired wound healing compositions and treatments |
| WO2009085268A2 (en) | 2007-12-21 | 2009-07-09 | Coda Therapeutics, Inc. | Use of anti-connexin peptides, alone or in combination with anti-connexin polynucleotides, for the treatment of surgical adhesions |
| AU2008343840A1 (en) | 2007-12-21 | 2009-07-09 | Coda Therapeutics, Inc. | Use of anti-connexin polynucleotides, peptides or antibodies for the treatment of orthopedic conditions |
| WO2009085271A2 (en) | 2007-12-21 | 2009-07-09 | Coda Therapeutics, Inc. | Use of anti-connexin peptides, alone or in combination with anti-connexin polynucleotides, for the treatment of orthopedic conditions |
| JP2011507859A (ja) | 2007-12-21 | 2011-03-10 | コーダ セラピューティクス， インコーポレイテッド | 外科的癒着の治療のための抗コネキシンポリヌクレオチドの使用 |
| CA2710386A1 (en) | 2007-12-21 | 2009-07-09 | Coda Therapeutics, Inc. | Improved medical devices |
| EP2252320A2 (en) | 2007-12-21 | 2010-11-24 | Coda Therapeutics, Inc. | Use of anti-connexin polynucleotides and peptides for the treatment of abnormal or excessive scars |
| US8975237B2 (en) | 2007-12-21 | 2015-03-10 | Coda Therapeutics, Inc. | Treatment of fibrotic conditions |
| US20110092449A1 (en) | 2007-12-21 | 2011-04-21 | Bradford James Duft | Treatment of fibrotic conditions |
| EP2252690A2 (en) | 2007-12-21 | 2010-11-24 | Coda Therapeutics, Inc. | Use of anti-connexin 43 polynucleotides for the treatment of abnormal or excessive scars |
| CA2711635A1 (en) | 2008-01-07 | 2009-08-06 | Coda Therapeutics, Inc. | Wound healing compositions and treatments |
| US20110223204A1 (en) | 2008-06-04 | 2011-09-15 | Bradford J Duft | Treatment of pain with gap junction modulation compounds |
-
2008
- 2008-12-22 US US12/809,886 patent/US8975237B2/en not_active Expired - Fee Related
- 2008-12-22 JP JP2010539513A patent/JP2011507857A/ja active Pending
- 2008-12-22 AU AU2008343841A patent/AU2008343841A1/en not_active Abandoned
- 2008-12-22 WO PCT/US2008/014021 patent/WO2009085270A2/en not_active Ceased
- 2008-12-22 EP EP08866327A patent/EP2237786A2/en not_active Withdrawn
- 2008-12-22 CA CA2710380A patent/CA2710380A1/en not_active Abandoned
-
2015
- 2015-03-09 US US14/642,582 patent/US9738892B2/en active Active
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