JP2011506334A - 免疫応答を誘導するための組成物 - Google Patents
免疫応答を誘導するための組成物 Download PDFInfo
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- JP2011506334A JP2011506334A JP2010537045A JP2010537045A JP2011506334A JP 2011506334 A JP2011506334 A JP 2011506334A JP 2010537045 A JP2010537045 A JP 2010537045A JP 2010537045 A JP2010537045 A JP 2010537045A JP 2011506334 A JP2011506334 A JP 2011506334A
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- immunogenic composition
- antigen
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
- A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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| WO2015053354A1 (ja) * | 2013-10-09 | 2015-04-16 | 東レ株式会社 | 免疫賦活化剤 |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2010254549B2 (en) | 2009-05-27 | 2016-10-20 | Selecta Biosciences, Inc. | Nanocarriers possessing components with different rates of release |
| PT2525815E (pt) * | 2010-01-24 | 2015-03-05 | Novartis Ag | Micropartículas de polímero biodegradável irradiadas |
| CN105194665A (zh) * | 2010-05-26 | 2015-12-30 | 西莱克塔生物科技公司 | 具有不偶合的佐剂的纳米载体组合物 |
| WO2012061717A1 (en) | 2010-11-05 | 2012-05-10 | Selecta Biosciences, Inc. | Modified nicotinic compounds and related methods |
| EP2694040A4 (en) * | 2011-03-25 | 2014-09-03 | Selecta Biosciences Inc | SYNTHETIC NANOTRACKERS WITH OSMOTICALLY MEDIATED RELEASE |
| CA2843274A1 (en) | 2011-07-29 | 2013-02-07 | Selecta Biosciences, Inc. | Synthetic nanocarriers that generate humoral and cytotoxic t lymphocyte (ctl) immune responses |
| US9358461B2 (en) * | 2012-12-26 | 2016-06-07 | Sony Interactive Entertainment America Llc | Systems and methods for ranking of cloud executed mini-games based on tag content and social network content |
| US9107906B1 (en) | 2014-10-28 | 2015-08-18 | Adma Biologics, Inc. | Compositions and methods for the treatment of immunodeficiency |
| US10259865B2 (en) | 2017-03-15 | 2019-04-16 | Adma Biologics, Inc. | Anti-pneumococcal hyperimmune globulin for the treatment and prevention of pneumococcal infection |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH09504523A (ja) * | 1993-10-22 | 1997-05-06 | ジェネンテク，インコーポレイテッド | アジュバントのマイクロカプセル化方法および組成物 |
| JP2001521908A (ja) * | 1997-10-31 | 2001-11-13 | シストロン バイオテクノロジー インク． | ワクチンアジュバントとして有用な封入された免疫調節物質 |
| JP2005514326A (ja) * | 2001-07-10 | 2005-05-19 | コリクサ コーポレイション | ミクロスフェア中に封入されたタンパク質およびアジュバントを送達するための組成物および方法 |
| WO2006031878A2 (en) * | 2004-09-14 | 2006-03-23 | Novartis Vaccines And Diagnostics Inc. | Imidazoquinoline compounds |
| WO2007100699A2 (en) * | 2006-02-24 | 2007-09-07 | Novartis Ag | Microparticles containing biodegradable polymer and cationic polysaccharide for use in immunogenic compositions |
Family Cites Families (80)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2800457A (en) | 1953-06-30 | 1957-07-23 | Ncr Co | Oil-containing microscopic capsules and method of making them |
| BE634667A (cg-RX-API-DMAC7.html) | 1962-07-11 | |||
| EP0142192A1 (en) | 1983-10-22 | 1985-05-22 | Akzo N.V. | Preparation of immunogens consisting of antigenic determinates bound to glycoside-containing carriers |
| US5324513A (en) | 1984-03-07 | 1994-06-28 | Institut Pasteur | Composition useful for the fabrication of vaccines |
| US5171568A (en) | 1984-04-06 | 1992-12-15 | Chiron Corporation | Recombinant herpes simplex gb-gd vaccine |
| US5098704A (en) | 1984-06-18 | 1992-03-24 | Chiron Corporation | Hepatitis surface antigen particle vaccine |
| US4722840A (en) | 1984-09-12 | 1988-02-02 | Chiron Corporation | Hybrid particle immunogens |
| US4727136A (en) | 1985-10-01 | 1988-02-23 | Canadian Patents And Development Ltd. | Modified meningococcal group B polysaccharide for conjugate vaccine |
| JP2661044B2 (ja) | 1986-06-17 | 1997-10-08 | カイロン コーポレイション | 肝炎δの診断薬およびワクチン |
| EP0318216B2 (en) | 1987-11-18 | 2001-08-29 | Chiron Corporation | NANBV diagnostics |
| US5350671A (en) | 1987-11-18 | 1994-09-27 | Chiron Corporation | HCV immunoassays employing C domain antigens |
| GB8815795D0 (en) | 1988-07-02 | 1988-08-10 | Bkl Extrusions Ltd | Glazing bead |
| KR0185373B1 (ko) | 1989-03-17 | 1999-05-01 | 로버트 피. 블랙버언 | Hcv 폴리단백질에서 유래되는 hcv 아미노산 서열 부분을 포함하는 폴리펩티드 및 그 사용 |
| AU638719B2 (en) | 1989-05-18 | 1993-07-08 | Novartis Vaccines And Diagnostics, Inc. | Nanbv diagnostics: polynucleotides useful for screening for hepatitis c virus |
| HU212924B (en) | 1989-05-25 | 1996-12-30 | Chiron Corp | Adjuvant formulation comprising a submicron oil droplet emulsion |
| AU641715B2 (en) | 1989-12-14 | 1993-09-30 | National Research Council Of Canada | Improved meningococcal polysaccharide conjugate vaccine |
| US5614612A (en) | 1990-03-09 | 1997-03-25 | Haigwood; Nancy L. | Purified gp120 compositions retaining natural conformation |
| US6274148B1 (en) | 1990-11-08 | 2001-08-14 | Chiron Corporation | Hepatitis C virus asialoglycoproteins |
| US5389640A (en) * | 1991-03-01 | 1995-02-14 | Minnesota Mining And Manufacturing Company | 1-substituted, 2-substituted 1H-imidazo[4,5-c]quinolin-4-amines |
| IL101715A (en) | 1991-05-02 | 2005-06-19 | Amgen Inc | Recombinant dna-derived cholera toxin subunit analogs |
| HU227547B1 (en) | 1991-06-24 | 2011-08-29 | Novartis Vaccines & Diagnostic | Hepatitis c virus (hcv) polypeptides |
| IT1253009B (it) | 1991-12-31 | 1995-07-10 | Sclavo Ricerca S R L | Mutanti immunogenici detossificati della tossina colerica e della tossina lt, loro preparazione ed uso per la preparazione di vaccini |
| UA39944C2 (uk) | 1992-07-07 | 2001-07-16 | Чірон Корпорейшн | Спосіб визначення ранньої сероконверсії у ссавця-хазяїна до вірусу гепатиту с і набір для використання в способі |
| ES2162139T5 (es) | 1993-03-23 | 2008-05-16 | Smithkline Beecham Biologicals S.A. | Composiciones de vacuna que contienen monofosforil-lipido a 3-o-desacilado. |
| GB9326253D0 (en) * | 1993-12-23 | 1994-02-23 | Smithkline Beecham Biolog | Vaccines |
| CA2560114A1 (en) | 1994-07-15 | 1996-02-01 | The University Of Iowa Research Foundation | Immunomodulatory oligonucleotides |
| US6207646B1 (en) | 1994-07-15 | 2001-03-27 | University Of Iowa Research Foundation | Immunostimulatory nucleic acid molecules |
| AU3241095A (en) | 1994-07-29 | 1996-03-04 | Chiron Corporation | Novel hepatitis c e1 and e2 truncated polypeptides and methods of obtaining the same |
| GB9422096D0 (en) | 1994-11-02 | 1994-12-21 | Biocine Spa | Combined meningitis vaccine |
| IL117483A (en) | 1995-03-17 | 2008-03-20 | Bernard Brodeur | MENINGITIDIS NEISSERIA shell protein is resistant to proteinase K. |
| US5843752A (en) | 1995-05-12 | 1998-12-01 | Schering Corporation | Soluble active hepatitis C virus protease |
| US5990276A (en) | 1996-05-10 | 1999-11-23 | Schering Corporation | Synthetic inhibitors of hepatitis C virus NS3 protease |
| IL126460A (en) | 1996-05-24 | 2007-07-04 | Novartis Vaccines & Diagnostic | Multiple epitope fusion protein |
| CA2268825C (en) | 1996-10-11 | 2006-04-18 | The Regents Of The University Of California | Immunostimulatory polynucleotide/immunomodulatory molecule conjugates |
| DE69812941T2 (de) | 1997-01-30 | 2004-02-05 | Chiron Corp. (N.D.Ges.D. Staates Delaware), Emeryville | Verwendung von mikropartikeln mit adsorbiertem antigen zur stimulierung der immunabwehr |
| EP0969862B1 (en) | 1997-02-07 | 2006-10-18 | Merck & Co., Inc. | Synthetic hiv gag genes |
| CA2281838A1 (en) | 1997-02-28 | 1998-09-03 | University Of Iowa Research Foundation | Use of nucleic acids containing unmethylated cpg dinucleotide in the treatment of lps-associated disorders |
| DE69841122D1 (de) | 1997-03-10 | 2009-10-15 | Coley Pharm Gmbh | Verwendung von nicht-methyliertem CpG Dinukleotid in Kombination mit Aluminium als Adjuvantien |
| CA2288129A1 (en) | 1997-05-01 | 1998-11-12 | Chiron Corporation | Use of virus-like particles as adjuvants |
| ATE437951T1 (de) | 1997-05-06 | 2009-08-15 | Novartis Vaccines & Diagnostic | Intrazelluläre herstellung von verkürztem hepatitis c-polypeptid e2 |
| US6355257B1 (en) | 1997-05-08 | 2002-03-12 | Corixa Corporation | Aminoalkyl glucosamine phosphate compounds and their use as adjuvants and immunoeffectors |
| EP1003531B1 (en) | 1997-05-20 | 2007-08-22 | Ottawa Health Research Institute | Processes for preparing nucleic acid constructs |
| ATE432348T1 (de) | 1997-06-06 | 2009-06-15 | Univ California | Inhibitoren von immunstimulatorischen dna sequenz aktivität |
| GB9712347D0 (en) | 1997-06-14 | 1997-08-13 | Smithkline Beecham Biolog | Vaccine |
| EP1007546B1 (en) | 1997-08-27 | 2009-01-21 | Novartis Vaccines and Diagnostics, Inc. | Molecular mimetics of meningococcal b epitopes |
| WO1999011241A1 (en) | 1997-09-05 | 1999-03-11 | Smithkline Beecham Biologicals S.A. | Oil in water emulsions containing saponins |
| ATE476508T1 (de) | 1997-11-06 | 2010-08-15 | Novartis Vaccines & Diagnostic | Neisseriale antigene |
| JP4918188B2 (ja) * | 1997-12-16 | 2012-04-18 | ノバルティス バクシンズ アンド ダイアグノスティックス，インコーポレーテッド | サブミクロンの水中油型エマルジョンと合わせた微粒子の使用 |
| JP4399112B2 (ja) | 1998-01-14 | 2010-01-13 | カイロン ソチエタ ア レスポンサビリタ リミタータ | ＮｅｉｓｓｅｒｉａＭｅｎｉｎｇｉｔｉｄｉｓ抗原 |
| US6303114B1 (en) | 1998-03-05 | 2001-10-16 | The Medical College Of Ohio | IL-12 enhancement of immune responses to T-independent antigens |
| HUP0101619A3 (en) | 1998-04-09 | 2003-11-28 | Smithkline Beecham Biolog | Adjuvant compositions |
| EP2261357A3 (en) | 1998-05-01 | 2012-01-11 | Novartis Vaccines and Diagnostics, Inc. | Neisseria meningitidis antigens and compositions |
| ATE321535T1 (de) | 1998-07-29 | 2006-04-15 | Chiron Corp | Mikropartikel mit adsorbenten oberflächen, verfahren zu ihrer herstellung und ihrer verwendung |
| JP2004511201A (ja) | 1998-10-09 | 2004-04-15 | カイロン コーポレイション | ナイセリアゲノム配列およびそれらの使用方法 |
| CA2358385C (en) | 1998-12-31 | 2013-08-06 | Chiron Corporation | Polynucleotides encoding antigenic hiv type c polypeptides, polypeptides and uses thereof |
| JP2002533124A (ja) | 1998-12-31 | 2002-10-08 | カイロン コーポレイション | Ｈｉｖポリペプチドの改善された発現およびウイルス様粒子の生成 |
| ES2223464T3 (es) | 1999-02-01 | 2005-03-01 | Eisai Co., Ltd. | Compuestos adyuvantes inmunologicos. |
| CA2363141C (en) | 1999-02-26 | 2010-04-06 | Chiron Corporation | Microemulsions with adsorbed macromolecules and microparticles |
| TWI281403B (en) | 1999-03-19 | 2007-05-21 | Smithkline Beecham Biolog | Vaccine |
| DK1187629T3 (da) | 1999-04-19 | 2005-01-17 | Glaxosmithkline Biolog Sa | Adjuvanssammensætning omfattende saponin og et immunostimulerende oligonucleotid |
| WO2001021207A2 (en) | 1999-09-24 | 2001-03-29 | Smithkline Beecham Biologicals S.A. | Use of combination of polyoxyethylene sorbitan ester and octoxynol as adjuvant and its use in vaccines |
| CA2383110A1 (en) | 1999-09-24 | 2001-03-29 | Veronique Henderickx | Adjuvant comprising a polyoxyethylene alkyl ether or ester and at least one non-ionic surfactant |
| ATE454901T1 (de) | 1999-10-13 | 2010-01-15 | Novartis Vaccines & Diagnostic | Verfahren zur erhaltung zellimmuneantworten gegen proteinen |
| GB0023008D0 (en) | 2000-09-20 | 2000-11-01 | Glaxo Group Ltd | Improvements in vaccination |
| NZ532274A (en) | 2001-10-03 | 2006-02-24 | Chiron Corp | Adjuvanted meningococcus compositions |
| AR045702A1 (es) | 2001-10-03 | 2005-11-09 | Chiron Corp | Composiciones de adyuvantes. |
| AU2002360278A1 (en) * | 2001-10-12 | 2003-11-11 | Coley Pharmaceutical Gmbh | Methods and products for enhancing immune responses using imidazoquinoline compounds |
| CA2470421A1 (en) | 2001-12-21 | 2003-07-24 | Children's Hospital & Regional Medical Center | Use of a novel cell surface protease from group b streptococcus |
| CA2476626A1 (en) * | 2002-02-20 | 2003-08-28 | Chiron Corporation | Microparticles with adsorbed polypeptide-containing molecules |
| GB0206461D0 (en) | 2002-03-19 | 2002-05-01 | Glaxo Group Ltd | Improvements in vaccination |
| DE60335350D1 (de) * | 2002-03-19 | 2011-01-27 | Powderject Res Ltd | Adjuvantien für dns impstoffe basierend auf imidazochinoline |
| US8034378B2 (en) | 2002-12-27 | 2011-10-11 | Novartis Vaccines And Diagnostics, Inc | Immunogenic compositions containing phospholipid |
| WO2004060308A2 (en) | 2002-12-27 | 2004-07-22 | Chiron Corporation | Thiosemicarbazones as anti-virals and immunopotentiators |
| WO2004064759A2 (en) | 2003-01-21 | 2004-08-05 | Chiron Corporation | Use of tryptanthrin compounds for immune potentiation |
| US7731967B2 (en) * | 2003-04-30 | 2010-06-08 | Novartis Vaccines And Diagnostics, Inc. | Compositions for inducing immune responses |
| PL1631264T5 (pl) * | 2003-06-02 | 2018-09-28 | Glaxosmithkline Biologicals Sa | Kompozycje immunogenne oparte na biodegradowalnych mikrocząstkach zawierających toksoid błonicy i tężca |
| DE102004032952A1 (de) * | 2004-07-07 | 2006-01-26 | Leica Microsystems Cms Gmbh | Rastermikroskop und Verfahren zur Untersuchung von biologischen Proben mit einem Rastermikroskop |
| ES2434029T3 (es) | 2004-11-15 | 2013-12-13 | Novartis Vaccines And Diagnostics, Inc. | Composiciones inmunogénicas que contiene antígeno de antrax, micropartículas de polímero biodegradable, y adyuvante inmunológico que contiene polinucleótido |
| EP2368573A3 (en) * | 2005-11-04 | 2013-05-01 | Novartis Vaccines and Diagnostics S.r.l. | Influenza vaccines including combinations of particulate adjuvants and immunopotentiators |
| EP2010530A2 (en) | 2006-03-23 | 2009-01-07 | Novartis AG | Methods for the preparation of imidazole-containing compounds |
-
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2014
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Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH09504523A (ja) * | 1993-10-22 | 1997-05-06 | ジェネンテク，インコーポレイテッド | アジュバントのマイクロカプセル化方法および組成物 |
| JP2001521908A (ja) * | 1997-10-31 | 2001-11-13 | シストロン バイオテクノロジー インク． | ワクチンアジュバントとして有用な封入された免疫調節物質 |
| JP2005514326A (ja) * | 2001-07-10 | 2005-05-19 | コリクサ コーポレイション | ミクロスフェア中に封入されたタンパク質およびアジュバントを送達するための組成物および方法 |
| WO2006031878A2 (en) * | 2004-09-14 | 2006-03-23 | Novartis Vaccines And Diagnostics Inc. | Imidazoquinoline compounds |
| WO2007100699A2 (en) * | 2006-02-24 | 2007-09-07 | Novartis Ag | Microparticles containing biodegradable polymer and cationic polysaccharide for use in immunogenic compositions |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2015053354A1 (ja) * | 2013-10-09 | 2015-04-16 | 東レ株式会社 | 免疫賦活化剤 |
| JPWO2015053354A1 (ja) * | 2013-10-09 | 2017-03-09 | 東レ株式会社 | 免疫賦活化剤 |
| US10556004B2 (en) | 2013-10-09 | 2020-02-11 | Toray Industries, Inc. | Immunopotentiator |
Also Published As
| Publication number | Publication date |
|---|---|
| EP3067048B1 (en) | 2018-02-14 |
| JP6013400B2 (ja) | 2016-10-25 |
| AU2008335457A1 (en) | 2009-06-18 |
| CA2708145A1 (en) | 2009-06-18 |
| AU2008335457A8 (en) | 2011-06-09 |
| WO2009076158A1 (en) | 2009-06-18 |
| AU2008335457B2 (en) | 2015-04-16 |
| ES2664753T3 (es) | 2018-04-23 |
| EP3067048A1 (en) | 2016-09-14 |
| US20110135679A1 (en) | 2011-06-09 |
| JP2014159486A (ja) | 2014-09-04 |
| EP2244695A1 (en) | 2010-11-03 |
| CA2708145C (en) | 2015-10-13 |
| WO2009076158A8 (en) | 2010-07-29 |
| US8815253B2 (en) | 2014-08-26 |
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