JP2011504374A - 繊維状ポリペプチドおよび多糖を含む組成物 - Google Patents

Info

Publication number

JP2011504374A

JP2011504374A JP2010535508A JP2010535508A JP2011504374A JP 2011504374 A JP2011504374 A JP 2011504374A JP 2010535508 A JP2010535508 A JP 2010535508A JP 2010535508 A JP2010535508 A JP 2010535508A JP 2011504374 A JP2011504374 A JP 2011504374A

Authority

JP

Japan

Prior art keywords

polypeptide

binding domain

seq

isolated

protein

Prior art date

2007-11-26

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
• Global Dossier
• Discuss

• 102000004196 processed proteins & peptides Human genes 0.000 title claims abstract description 222
• 108090000765 processed proteins & peptides Proteins 0.000 title claims abstract description 222
• 229920001184 polypeptide Polymers 0.000 title claims abstract description 220
• 229920001282 polysaccharide Polymers 0.000 title claims abstract description 88
• 239000005017 polysaccharide Substances 0.000 title claims abstract description 88
• 239000000203 mixture Substances 0.000 title claims description 45
• 150000004676 glycans Chemical class 0.000 title abstract 3
• 230000027455 binding Effects 0.000 claims abstract description 142
• 229920002678 cellulose Polymers 0.000 claims abstract description 114
• 239000001913 cellulose Substances 0.000 claims abstract description 113
• 239000000178 monomer Substances 0.000 claims abstract description 24
• 125000003275 alpha amino acid group Chemical group 0.000 claims abstract 7
• 108090000623 proteins and genes Proteins 0.000 claims description 263
• 102000004169 proteins and genes Human genes 0.000 claims description 198
• 229920002781 resilin Polymers 0.000 claims description 126
• 238000000034 method Methods 0.000 claims description 117
• 235000010980 cellulose Nutrition 0.000 claims description 98
• 229920001872 Spider silk Polymers 0.000 claims description 94
• 239000002131 composite material Substances 0.000 claims description 89
• 150000004804 polysaccharides Chemical class 0.000 claims description 85
• 230000014509 gene expression Effects 0.000 claims description 64
• 150000007523 nucleic acids Chemical group 0.000 claims description 45
• 229920002101 Chitin Polymers 0.000 claims description 44
• 238000004132 cross linking Methods 0.000 claims description 44
• 108091033319 polynucleotide Proteins 0.000 claims description 41
• 102000040430 polynucleotide Human genes 0.000 claims description 41
• 239000002157 polynucleotide Substances 0.000 claims description 41
• 229920001436 collagen Polymers 0.000 claims description 28
• 102000039446 nucleic acids Human genes 0.000 claims description 28
• 108020004707 nucleic acids Proteins 0.000 claims description 28
• 108010035532 Collagen Proteins 0.000 claims description 27
• 102000008186 Collagen Human genes 0.000 claims description 27
• 108010014258 Elastin Proteins 0.000 claims description 25
• 102000016942 Elastin Human genes 0.000 claims description 25
• 229920002549 elastin Polymers 0.000 claims description 25
• 239000012634 fragment Substances 0.000 claims description 21
• 238000004519 manufacturing process Methods 0.000 claims description 21
• 108091028043 Nucleic acid sequence Proteins 0.000 claims description 20
• 241000255789 Bombyx mori Species 0.000 claims description 17
• 239000008194 pharmaceutical composition Substances 0.000 claims description 17
• 229920002472 Starch Polymers 0.000 claims description 16
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 16
• 239000007924 injection Substances 0.000 claims description 16
• 238000002347 injection Methods 0.000 claims description 16
• 239000008107 starch Substances 0.000 claims description 15
• 235000019698 starch Nutrition 0.000 claims description 15
• KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims description 14
• 229920002307 Dextran Polymers 0.000 claims description 14
• 239000003814 drug Substances 0.000 claims description 14
• 229920002674 hyaluronan Polymers 0.000 claims description 14
• 229960003160 hyaluronic acid Drugs 0.000 claims description 14
• 230000001105 regulatory effect Effects 0.000 claims description 14
• 229920000615 alginic acid Polymers 0.000 claims description 13
• 235000010443 alginic acid Nutrition 0.000 claims description 13
• 210000000845 cartilage Anatomy 0.000 claims description 13
• 239000002537 cosmetic Substances 0.000 claims description 13
• 229920001661 Chitosan Polymers 0.000 claims description 12
• 241000237536 Mytilus edulis Species 0.000 claims description 12
• 229940045110 chitosan Drugs 0.000 claims description 12
• 210000002683 foot Anatomy 0.000 claims description 12
• 235000020638 mussel Nutrition 0.000 claims description 12
• 108010076504 Protein Sorting Signals Proteins 0.000 claims description 11
• 208000015100 cartilage disease Diseases 0.000 claims description 10
• 239000011248 coating agent Substances 0.000 claims description 10
• 238000000576 coating method Methods 0.000 claims description 10
• 230000008439 repair process Effects 0.000 claims description 10
• FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 claims description 9
• 229940072056 alginate Drugs 0.000 claims description 9
• 208000035475 disorder Diseases 0.000 claims description 9
• 108090001082 glucan-binding proteins Proteins 0.000 claims description 9
• 206010046543 Urinary incontinence Diseases 0.000 claims description 8
• 208000020084 Bone disease Diseases 0.000 claims description 7
• 201000008482 osteoarthritis Diseases 0.000 claims description 6
• 229920001503 Glucan Polymers 0.000 claims description 5
• 101000717362 Acetabularia peniculus Ribulose bisphosphate carboxylase small subunit, chloroplastic 7 Proteins 0.000 claims description 4
• 108010067306 Fibronectins Proteins 0.000 claims description 4
• 102000016359 Fibronectins Human genes 0.000 claims description 4
• 108700007698 Genetic Terminator Regions Proteins 0.000 claims description 4
• 239000000783 alginic acid Substances 0.000 claims description 4
• 229960001126 alginic acid Drugs 0.000 claims description 4
• 150000004781 alginic acids Chemical class 0.000 claims description 4
• 210000003127 knee Anatomy 0.000 claims description 4
• 206010058112 Chondrolysis Diseases 0.000 claims description 3
• 201000005569 Gout Diseases 0.000 claims description 3
• 206010039710 Scleroderma Diseases 0.000 claims description 3
• 239000001768 carboxy methyl cellulose Substances 0.000 claims description 3
• 210000003797 carpal joint Anatomy 0.000 claims description 3
• 238000010382 chemical cross-linking Methods 0.000 claims description 3
• 230000003412 degenerative effect Effects 0.000 claims description 3
• 210000002310 elbow joint Anatomy 0.000 claims description 3
• 230000002255 enzymatic effect Effects 0.000 claims description 3
• 210000004394 hip joint Anatomy 0.000 claims description 3
• 238000001802 infusion Methods 0.000 claims description 3
• 210000001503 joint Anatomy 0.000 claims description 3
• 210000000629 knee joint Anatomy 0.000 claims description 3
• 206010039073 rheumatoid arthritis Diseases 0.000 claims description 3
• 210000001898 sternoclavicular joint Anatomy 0.000 claims description 3
• 201000000596 systemic lupus erythematosus Diseases 0.000 claims description 3
• 210000003708 urethra Anatomy 0.000 claims description 3
• 229920002134 Carboxymethyl cellulose Polymers 0.000 claims description 2
• 210000000544 articulatio talocruralis Anatomy 0.000 claims description 2
• 235000010948 carboxy methyl cellulose Nutrition 0.000 claims description 2
• 239000008112 carboxymethyl-cellulose Substances 0.000 claims description 2
• 229940105329 carboxymethylcellulose Drugs 0.000 claims description 2
• 239000006260 foam Substances 0.000 claims description 2
• 210000001061 forehead Anatomy 0.000 claims description 2
• 238000002955 isolation Methods 0.000 claims description 2
• 210000003041 ligament Anatomy 0.000 claims description 2
• 239000000314 lubricant Substances 0.000 claims description 2
• 210000004341 tarsal joint Anatomy 0.000 claims description 2
• 210000003857 wrist joint Anatomy 0.000 claims description 2
• 235000018102 proteins Nutrition 0.000 description 184
• 108010019116 resilin Proteins 0.000 description 99
• 241000196324 Embryophyta Species 0.000 description 83
• 150000001413 amino acids Chemical group 0.000 description 66
• 238000000746 purification Methods 0.000 description 53
• 210000004027 cell Anatomy 0.000 description 52
• RAXXELZNTBOGNW-UHFFFAOYSA-N imidazole Natural products C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 description 48
• 238000002415 sodium dodecyl sulfate polyacrylamide gel electrophoresis Methods 0.000 description 46
• 235000001014 amino acid Nutrition 0.000 description 45
• 238000004458 analytical method Methods 0.000 description 44
• 229940024606 amino acid Drugs 0.000 description 39
• 239000000463 material Substances 0.000 description 32
• 239000013598 vector Substances 0.000 description 31
• 239000000047 product Substances 0.000 description 29
• 238000006243 chemical reaction Methods 0.000 description 28
• 108020004705 Codon Proteins 0.000 description 26
• 108020004414 DNA Proteins 0.000 description 24
• OQALFHMKVSJFRR-UHFFFAOYSA-N dityrosine Chemical compound OC(=O)C(N)CC1=CC=C(O)C(C=2C(=CC=C(CC(N)C(O)=O)C=2)O)=C1 OQALFHMKVSJFRR-UHFFFAOYSA-N 0.000 description 24
• 239000000523 sample Substances 0.000 description 24
• 238000006467 substitution reaction Methods 0.000 description 24
• 239000000243 solution Substances 0.000 description 23
• 238000005119 centrifugation Methods 0.000 description 22
• 239000008188 pellet Substances 0.000 description 22
• 241000588724 Escherichia coli Species 0.000 description 21
• 238000000159 protein binding assay Methods 0.000 description 21
• ROOXNKNUYICQNP-UHFFFAOYSA-N ammonium persulfate Chemical compound [NH4+].[NH4+].[O-]S(=O)(=O)OOS([O-])(=O)=O ROOXNKNUYICQNP-UHFFFAOYSA-N 0.000 description 20
• 239000006166 lysate Substances 0.000 description 20
• 229920000642 polymer Polymers 0.000 description 20
• XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 20
• 239000000872 buffer Substances 0.000 description 19
• 238000006116 polymerization reaction Methods 0.000 description 19
• FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 18
• 239000013604 expression vector Substances 0.000 description 18
• 230000004927 fusion Effects 0.000 description 18
• 239000000499 gel Substances 0.000 description 18
• 210000001519 tissue Anatomy 0.000 description 18
• 241000894006 Bacteria Species 0.000 description 17
• 239000012460 protein solution Substances 0.000 description 17
• 238000002360 preparation method Methods 0.000 description 16
• 239000007787 solid Substances 0.000 description 16
• 235000002637 Nicotiana tabacum Nutrition 0.000 description 15
• 244000061176 Nicotiana tabacum Species 0.000 description 15
• 239000004480 active ingredient Substances 0.000 description 15
• 210000003000 inclusion body Anatomy 0.000 description 15
• 239000003550 marker Substances 0.000 description 15
• LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 14
• 230000004048 modification Effects 0.000 description 14
• 238000012986 modification Methods 0.000 description 14
• -1 peptin Polymers 0.000 description 14
• 239000002953 phosphate buffered saline Substances 0.000 description 14
• QFVHZQCOUORWEI-UHFFFAOYSA-N 4-[(4-anilino-5-sulfonaphthalen-1-yl)diazenyl]-5-hydroxynaphthalene-2,7-disulfonic acid Chemical compound C=12C(O)=CC(S(O)(=O)=O)=CC2=CC(S(O)(=O)=O)=CC=1N=NC(C1=CC=CC(=C11)S(O)(=O)=O)=CC=C1NC1=CC=CC=C1 QFVHZQCOUORWEI-UHFFFAOYSA-N 0.000 description 13
• 241000239290 Araneae Species 0.000 description 13
• 229910021591 Copper(I) chloride Inorganic materials 0.000 description 13
• 238000003556 assay Methods 0.000 description 13
• 238000010276 construction Methods 0.000 description 12
• OXBLHERUFWYNTN-UHFFFAOYSA-M copper(I) chloride Chemical compound [Cu]Cl OXBLHERUFWYNTN-UHFFFAOYSA-M 0.000 description 12
• 238000000502 dialysis Methods 0.000 description 12
• 125000003729 nucleotide group Chemical group 0.000 description 12
• 239000000725 suspension Substances 0.000 description 12
• 102000004190 Enzymes Human genes 0.000 description 11
• 108090000790 Enzymes Proteins 0.000 description 11
• 241000700605 Viruses Species 0.000 description 11
• 229940088598 enzyme Drugs 0.000 description 11
• 108020001507 fusion proteins Proteins 0.000 description 11
• 102000037865 fusion proteins Human genes 0.000 description 11
• 230000008569 process Effects 0.000 description 11
• 239000000126 substance Substances 0.000 description 11
• 108700010070 Codon Usage Proteins 0.000 description 10
• 229910001870 ammonium persulfate Inorganic materials 0.000 description 10
• 238000010367 cloning Methods 0.000 description 10
• 239000002773 nucleotide Substances 0.000 description 10
• 239000008363 phosphate buffer Substances 0.000 description 10
• 230000009466 transformation Effects 0.000 description 10
• 230000009261 transgenic effect Effects 0.000 description 10
• OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 9
• 108700005078 Synthetic Genes Proteins 0.000 description 9
• 230000001580 bacterial effect Effects 0.000 description 9
• 239000003795 chemical substances by application Substances 0.000 description 9
• 238000000338 in vitro Methods 0.000 description 9
• 238000003780 insertion Methods 0.000 description 9
• 230000037431 insertion Effects 0.000 description 9
• 239000002609 medium Substances 0.000 description 9
• 239000011780 sodium chloride Substances 0.000 description 9
• 238000011282 treatment Methods 0.000 description 9
• 229920002749 Bacterial cellulose Polymers 0.000 description 8
• MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 description 8
• 230000003321 amplification Effects 0.000 description 8
• 239000005016 bacterial cellulose Substances 0.000 description 8
• 239000012148 binding buffer Substances 0.000 description 8
• 210000004204 blood vessel Anatomy 0.000 description 8
• 238000004113 cell culture Methods 0.000 description 8
• 150000001875 compounds Chemical class 0.000 description 8
• 238000009472 formulation Methods 0.000 description 8
• 238000001727 in vivo Methods 0.000 description 8
• 238000003199 nucleic acid amplification method Methods 0.000 description 8
• 230000003647 oxidation Effects 0.000 description 8
• 238000007254 oxidation reaction Methods 0.000 description 8
• 238000001179 sorption measurement Methods 0.000 description 8
• 108091026890 Coding region Proteins 0.000 description 7
• 241001465754 Metazoa Species 0.000 description 7
• 102000003992 Peroxidases Human genes 0.000 description 7
• 229920002988 biodegradable polymer Polymers 0.000 description 7
• 239000004621 biodegradable polymer Substances 0.000 description 7
• 210000002808 connective tissue Anatomy 0.000 description 7
• 238000012217 deletion Methods 0.000 description 7
• 230000037430 deletion Effects 0.000 description 7
• 230000029087 digestion Effects 0.000 description 7
• 201000010099 disease Diseases 0.000 description 7
• 239000012149 elution buffer Substances 0.000 description 7
• 238000010438 heat treatment Methods 0.000 description 7
• 238000012360 testing method Methods 0.000 description 7
• 241000193169 Clostridium cellulovorans Species 0.000 description 6
• DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 6
• 241000238631 Hexapoda Species 0.000 description 6
• WTDRDQBEARUVNC-UHFFFAOYSA-N L-Dopa Natural products OC(=O)C(N)CC1=CC=C(O)C(O)=C1 WTDRDQBEARUVNC-UHFFFAOYSA-N 0.000 description 6
• OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 description 6
• AUNGANRZJHBGPY-SCRDCRAPSA-N Riboflavin Chemical compound OC[C@@H](O)[C@@H](O)[C@@H](O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-SCRDCRAPSA-N 0.000 description 6
• 108010003581 Ribulose-bisphosphate carboxylase Proteins 0.000 description 6
• 208000027418 Wounds and injury Diseases 0.000 description 6
• 230000015572 biosynthetic process Effects 0.000 description 6
• 239000002299 complementary DNA Substances 0.000 description 6
• 238000011161 development Methods 0.000 description 6
• 230000018109 developmental process Effects 0.000 description 6
• 238000000113 differential scanning calorimetry Methods 0.000 description 6
• 239000003623 enhancer Substances 0.000 description 6
• 239000000835 fiber Substances 0.000 description 6
• 239000007943 implant Substances 0.000 description 6
• 230000001965 increasing effect Effects 0.000 description 6
• 230000000670 limiting effect Effects 0.000 description 6
• 238000005457 optimization Methods 0.000 description 6
• 239000013612 plasmid Substances 0.000 description 6
• 230000002441 reversible effect Effects 0.000 description 6
• 238000012163 sequencing technique Methods 0.000 description 6
• QFJCIRLUMZQUOT-HPLJOQBZSA-N sirolimus Chemical compound C1C[C@@H](O)[C@H](OC)C[C@@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C1 QFJCIRLUMZQUOT-HPLJOQBZSA-N 0.000 description 6
• 230000014616 translation Effects 0.000 description 6
• 238000011144 upstream manufacturing Methods 0.000 description 6
• VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 5
• 108010022355 Fibroins Proteins 0.000 description 5
• SXRSQZLOMIGNAQ-UHFFFAOYSA-N Glutaraldehyde Chemical compound O=CCCCC=O SXRSQZLOMIGNAQ-UHFFFAOYSA-N 0.000 description 5
• 241000282412 Homo Species 0.000 description 5
• 108020004511 Recombinant DNA Proteins 0.000 description 5
• 239000004809 Teflon Substances 0.000 description 5
• 229920006362 Teflon® Polymers 0.000 description 5
• 241000723873 Tobacco mosaic virus Species 0.000 description 5
• 229920004890 Triton X-100 Polymers 0.000 description 5
• 206010052428 Wound Diseases 0.000 description 5
• 239000007864 aqueous solution Substances 0.000 description 5
• 230000004071 biological effect Effects 0.000 description 5
• 239000012620 biological material Substances 0.000 description 5
• 238000009835 boiling Methods 0.000 description 5
• 238000001938 differential scanning calorimetry curve Methods 0.000 description 5
• 230000000694 effects Effects 0.000 description 5
• 230000002349 favourable effect Effects 0.000 description 5
• 238000011065 in-situ storage Methods 0.000 description 5
• 238000011534 incubation Methods 0.000 description 5
• 208000015181 infectious disease Diseases 0.000 description 5
• 229960004502 levodopa Drugs 0.000 description 5
• 230000007774 longterm Effects 0.000 description 5
• 239000011159 matrix material Substances 0.000 description 5
• 229910052751 metal Inorganic materials 0.000 description 5
• 239000002184 metal Substances 0.000 description 5
• 239000000816 peptidomimetic Substances 0.000 description 5
• 230000005855 radiation Effects 0.000 description 5
• 230000003252 repetitive effect Effects 0.000 description 5
• 238000000527 sonication Methods 0.000 description 5
• 238000013518 transcription Methods 0.000 description 5
• 230000035897 transcription Effects 0.000 description 5
• 230000007704 transition Effects 0.000 description 5
• 238000013519 translation Methods 0.000 description 5
• OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 5
• 239000013603 viral vector Substances 0.000 description 5
• LMDZBCPBFSXMTL-UHFFFAOYSA-N 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide Chemical compound CCN=C=NCCCN(C)C LMDZBCPBFSXMTL-UHFFFAOYSA-N 0.000 description 4
• IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 4
• LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 4
• 239000004471 Glycine Substances 0.000 description 4
• COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 description 4
• 241001599018 Melanogaster Species 0.000 description 4
• 229920000954 Polyglycolide Polymers 0.000 description 4
• 108700009124 Transcription Initiation Site Proteins 0.000 description 4
• 230000003187 abdominal effect Effects 0.000 description 4
• 238000001042 affinity chromatography Methods 0.000 description 4
• 230000015556 catabolic process Effects 0.000 description 4
• 238000003776 cleavage reaction Methods 0.000 description 4
• 230000000295 complement effect Effects 0.000 description 4
• 238000006731 degradation reaction Methods 0.000 description 4
• 238000003795 desorption Methods 0.000 description 4
• MHUWZNTUIIFHAS-CLFAGFIQSA-N dioleoyl phosphatidic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OCC(COP(O)(O)=O)OC(=O)CCCCCCC\C=C/CCCCCCCC MHUWZNTUIIFHAS-CLFAGFIQSA-N 0.000 description 4
• VYFYYTLLBUKUHU-UHFFFAOYSA-N dopamine Chemical compound NCCC1=CC=C(O)C(O)=C1 VYFYYTLLBUKUHU-UHFFFAOYSA-N 0.000 description 4
• 229940079593 drug Drugs 0.000 description 4
• 238000002474 experimental method Methods 0.000 description 4
• 239000000284 extract Substances 0.000 description 4
• 230000012010 growth Effects 0.000 description 4
• 239000000017 hydrogel Substances 0.000 description 4
• NPZTUJOABDZTLV-UHFFFAOYSA-N hydroxybenzotriazole Substances O=C1C=CC=C2NNN=C12 NPZTUJOABDZTLV-UHFFFAOYSA-N 0.000 description 4
• 230000006698 induction Effects 0.000 description 4
• 239000006210 lotion Substances 0.000 description 4
• 108020004999 messenger RNA Proteins 0.000 description 4
• 238000010369 molecular cloning Methods 0.000 description 4
• 210000000056 organ Anatomy 0.000 description 4
• 108040007629 peroxidase activity proteins Proteins 0.000 description 4
• 239000000546 pharmaceutical excipient Substances 0.000 description 4
• 239000000843 powder Substances 0.000 description 4
• 239000002244 precipitate Substances 0.000 description 4
• 101150063585 resilin gene Proteins 0.000 description 4
• 230000007017 scission Effects 0.000 description 4
• 238000000926 separation method Methods 0.000 description 4
• 241000894007 species Species 0.000 description 4
• 231100000419 toxicity Toxicity 0.000 description 4
• 230000001988 toxicity Effects 0.000 description 4
• 230000001052 transient effect Effects 0.000 description 4
• 125000001493 tyrosinyl group Chemical group [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 description 4
• 230000002485 urinary effect Effects 0.000 description 4
• 230000003612 virological effect Effects 0.000 description 4
• 108091032973 (ribonucleotides)n+m Proteins 0.000 description 3
• QKNYBSVHEMOAJP-UHFFFAOYSA-N 2-amino-2-(hydroxymethyl)propane-1,3-diol;hydron;chloride Chemical compound Cl.OCC(N)(CO)CO QKNYBSVHEMOAJP-UHFFFAOYSA-N 0.000 description 3
• 244000037364 Cinnamomum aromaticum Species 0.000 description 3
• 235000014489 Cinnamomum aromaticum Nutrition 0.000 description 3
• 238000011537 Coomassie blue staining Methods 0.000 description 3
• RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 3
• AUNGANRZJHBGPY-UHFFFAOYSA-N D-Lyxoflavin Natural products OCC(O)C(O)C(O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-UHFFFAOYSA-N 0.000 description 3
• 102100037840 Dehydrogenase/reductase SDR family member 2, mitochondrial Human genes 0.000 description 3
• KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 3
• HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 description 3
• 241000209094 Oryza Species 0.000 description 3
• 239000004793 Polystyrene Substances 0.000 description 3
• 101710188053 Protein D Proteins 0.000 description 3
• 108010067787 Proteoglycans Proteins 0.000 description 3
• 102000016611 Proteoglycans Human genes 0.000 description 3
• 101710132893 Resolvase Proteins 0.000 description 3
• 240000004808 Saccharomyces cerevisiae Species 0.000 description 3
• HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
• 229920002125 Sokalan® Polymers 0.000 description 3
• 239000007983 Tris buffer Substances 0.000 description 3
• XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 3
• 210000003815 abdominal wall Anatomy 0.000 description 3
• 239000011543 agarose gel Substances 0.000 description 3
• 239000002260 anti-inflammatory agent Substances 0.000 description 3
• 229940124599 anti-inflammatory drug Drugs 0.000 description 3
• 230000008901 benefit Effects 0.000 description 3
• 239000012867 bioactive agent Substances 0.000 description 3
• 229920001222 biopolymer Polymers 0.000 description 3
• 210000000481 breast Anatomy 0.000 description 3
• 210000002421 cell wall Anatomy 0.000 description 3
• 238000012512 characterization method Methods 0.000 description 3
• 229910052802 copper Inorganic materials 0.000 description 3
• 239000000287 crude extract Substances 0.000 description 3
• 210000000805 cytoplasm Anatomy 0.000 description 3
• 230000001419 dependent effect Effects 0.000 description 3
• 239000002552 dosage form Substances 0.000 description 3
• 239000003937 drug carrier Substances 0.000 description 3
• 238000010828 elution Methods 0.000 description 3
• 238000005516 engineering process Methods 0.000 description 3
• 210000003527 eukaryotic cell Anatomy 0.000 description 3
• 238000000855 fermentation Methods 0.000 description 3
• 230000004151 fermentation Effects 0.000 description 3
• 230000006870 function Effects 0.000 description 3
• 210000004209 hair Anatomy 0.000 description 3
• 210000002216 heart Anatomy 0.000 description 3
• 238000010348 incorporation Methods 0.000 description 3
• 229930027917 kanamycin Natural products 0.000 description 3
• 229960000318 kanamycin Drugs 0.000 description 3
• SBUJHOSQTJFQJX-NOAMYHISSA-N kanamycin Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CN)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](N)[C@H](O)[C@@H](CO)O2)O)[C@H](N)C[C@@H]1N SBUJHOSQTJFQJX-NOAMYHISSA-N 0.000 description 3
• 229930182823 kanamycin A Natural products 0.000 description 3
• 239000007788 liquid Substances 0.000 description 3
• 238000002156 mixing Methods 0.000 description 3
• 239000013642 negative control Substances 0.000 description 3
• 229910052760 oxygen Inorganic materials 0.000 description 3
• 239000002245 particle Substances 0.000 description 3
• 239000000419 plant extract Substances 0.000 description 3
• 229920001610 polycaprolactone Polymers 0.000 description 3
• 229920001223 polyethylene glycol Polymers 0.000 description 3
• 229920002223 polystyrene Polymers 0.000 description 3
• 239000003642 reactive oxygen metabolite Substances 0.000 description 3
• 238000010188 recombinant method Methods 0.000 description 3
• 230000008929 regeneration Effects 0.000 description 3
• 238000011069 regeneration method Methods 0.000 description 3
• 235000019192 riboflavin Nutrition 0.000 description 3
• 239000002151 riboflavin Substances 0.000 description 3
• 229960002477 riboflavin Drugs 0.000 description 3
• 231100000241 scar Toxicity 0.000 description 3
• 150000003384 small molecules Chemical class 0.000 description 3
• 239000001488 sodium phosphate Substances 0.000 description 3
• 229910000162 sodium phosphate Inorganic materials 0.000 description 3
• 235000000346 sugar Nutrition 0.000 description 3
• 239000006228 supernatant Substances 0.000 description 3
• 238000001757 thermogravimetry curve Methods 0.000 description 3
• 238000012546 transfer Methods 0.000 description 3
• LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 3
• RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 3
• 241001430294 unidentified retrovirus Species 0.000 description 3
• 239000003981 vehicle Substances 0.000 description 3
• 238000001262 western blot Methods 0.000 description 3
• GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 2
• OYIFNHCXNCRBQI-UHFFFAOYSA-N 2-aminoadipic acid Chemical compound OC(=O)C(N)CCCC(O)=O OYIFNHCXNCRBQI-UHFFFAOYSA-N 0.000 description 2
• ZJSQZQMVXKZAGW-UHFFFAOYSA-N 2H-benzotriazol-4-ol hydrate Chemical compound O.OC1=CC=CC2=C1N=NN2 ZJSQZQMVXKZAGW-UHFFFAOYSA-N 0.000 description 2
• 108020003589 5' Untranslated Regions Proteins 0.000 description 2
• 101710191899 Actin-depolymerizing factor 3 Proteins 0.000 description 2
• CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 2
• 108010077805 Bacterial Proteins Proteins 0.000 description 2
• 235000012905 Brassica oleracea var viridis Nutrition 0.000 description 2
• 235000008635 Cadaba farinosa Nutrition 0.000 description 2
• CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 2
• 108090000317 Chymotrypsin Proteins 0.000 description 2
• 235000007460 Coffea arabica Nutrition 0.000 description 2
• 240000007154 Coffea arabica Species 0.000 description 2
• 239000005751 Copper oxide Substances 0.000 description 2
• 241001507946 Cotoneaster Species 0.000 description 2
• JPVYNHNXODAKFH-UHFFFAOYSA-N Cu2+ Chemical compound [Cu+2] JPVYNHNXODAKFH-UHFFFAOYSA-N 0.000 description 2
• 235000017788 Cydonia oblonga Nutrition 0.000 description 2
• 241000701022 Cytomegalovirus Species 0.000 description 2
• 108010014303 DNA-directed DNA polymerase Proteins 0.000 description 2
• 102000016928 DNA-directed DNA polymerase Human genes 0.000 description 2
• 108010067770 Endopeptidase K Proteins 0.000 description 2
• 102000010834 Extracellular Matrix Proteins Human genes 0.000 description 2
• 108010037362 Extracellular Matrix Proteins Proteins 0.000 description 2
• 108010010803 Gelatin Proteins 0.000 description 2
• 108700028146 Genetic Enhancer Elements Proteins 0.000 description 2
• AZKVWQKMDGGDSV-BCMRRPTOSA-N Genipin Chemical compound COC(=O)C1=CO[C@@H](O)[C@@H]2C(CO)=CC[C@H]12 AZKVWQKMDGGDSV-BCMRRPTOSA-N 0.000 description 2
• PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 2
• 229920002683 Glycosaminoglycan Polymers 0.000 description 2
• 240000005979 Hordeum vulgare Species 0.000 description 2
• 235000007340 Hordeum vulgare Nutrition 0.000 description 2
• 206010020649 Hyperkeratosis Diseases 0.000 description 2
• 108020004684 Internal Ribosome Entry Sites Proteins 0.000 description 2
• 108010093008 Kinins Proteins 0.000 description 2
• 102000002397 Kinins Human genes 0.000 description 2
• WTDRDQBEARUVNC-LURJTMIESA-N L-DOPA Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C(O)=C1 WTDRDQBEARUVNC-LURJTMIESA-N 0.000 description 2
• 108010085895 Laminin Proteins 0.000 description 2
• 102000007547 Laminin Human genes 0.000 description 2
• 240000007472 Leucaena leucocephala Species 0.000 description 2
• 235000010643 Leucaena leucocephala Nutrition 0.000 description 2
• 240000003183 Manihot esculenta Species 0.000 description 2
• 241000219823 Medicago Species 0.000 description 2
• 241000218666 Metasequoia Species 0.000 description 2
• 240000008790 Musa x paradisiaca Species 0.000 description 2
• 235000018290 Musa x paradisiaca Nutrition 0.000 description 2
• PXHVJJICTQNCMI-UHFFFAOYSA-N Nickel Chemical compound [Ni] PXHVJJICTQNCMI-UHFFFAOYSA-N 0.000 description 2
• BZQFBWGGLXLEPQ-UHFFFAOYSA-N O-phosphoryl-L-serine Natural products OC(=O)C(N)COP(O)(O)=O BZQFBWGGLXLEPQ-UHFFFAOYSA-N 0.000 description 2
• 235000007164 Oryza sativa Nutrition 0.000 description 2
• 102000035195 Peptidases Human genes 0.000 description 2
• 108091005804 Peptidases Proteins 0.000 description 2
• 108700020962 Peroxidase Proteins 0.000 description 2
• 244000297511 Phoenix canariensis Species 0.000 description 2
• 241000219843 Pisum Species 0.000 description 2
• 108700001094 Plant Genes Proteins 0.000 description 2
• 229920002732 Polyanhydride Polymers 0.000 description 2
• 229920001710 Polyorthoester Polymers 0.000 description 2
• 239000004743 Polypropylene Substances 0.000 description 2
• 239000004365 Protease Substances 0.000 description 2
• 108010092799 RNA-directed DNA polymerase Proteins 0.000 description 2
• 108010008281 Recombinant Fusion Proteins Proteins 0.000 description 2
• 102000007056 Recombinant Fusion Proteins Human genes 0.000 description 2
• 241000714474 Rous sarcoma virus Species 0.000 description 2
• 244000061456 Solanum tuberosum Species 0.000 description 2
• 241000191967 Staphylococcus aureus Species 0.000 description 2
• 108700026226 TATA Box Proteins 0.000 description 2
• 108010006785 Taq Polymerase Proteins 0.000 description 2
• 208000007536 Thrombosis Diseases 0.000 description 2
• 208000036142 Viral infection Diseases 0.000 description 2
• 241001464837 Viridiplantae Species 0.000 description 2
• 240000008042 Zea mays Species 0.000 description 2
• 239000002253 acid Substances 0.000 description 2
• 239000013543 active substance Substances 0.000 description 2
• 239000002671 adjuvant Substances 0.000 description 2
• 238000001261 affinity purification Methods 0.000 description 2
• 229960000723 ampicillin Drugs 0.000 description 2
• AVKUERGKIZMTKX-NJBDSQKTSA-N ampicillin Chemical compound C1([C@@H](N)C(=O)N[C@H]2[C@H]3SC([C@@H](N3C2=O)C(O)=O)(C)C)=CC=CC=C1 AVKUERGKIZMTKX-NJBDSQKTSA-N 0.000 description 2
• 238000010171 animal model Methods 0.000 description 2
• 229940121363 anti-inflammatory agent Drugs 0.000 description 2
• 239000003146 anticoagulant agent Substances 0.000 description 2
• QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 2
• 230000003416 augmentation Effects 0.000 description 2
• 239000011173 biocomposite Substances 0.000 description 2
• 210000004899 c-terminal region Anatomy 0.000 description 2
• 229910000019 calcium carbonate Inorganic materials 0.000 description 2
• 229910052799 carbon Inorganic materials 0.000 description 2
• YCIMNLLNPGFGHC-UHFFFAOYSA-N catechol Chemical compound OC1=CC=CC=C1O YCIMNLLNPGFGHC-UHFFFAOYSA-N 0.000 description 2
• 230000021164 cell adhesion Effects 0.000 description 2
• 230000010261 cell growth Effects 0.000 description 2
• 210000000170 cell membrane Anatomy 0.000 description 2
• 230000001413 cellular effect Effects 0.000 description 2
• 239000000919 ceramic Substances 0.000 description 2
• 239000003153 chemical reaction reagent Substances 0.000 description 2
• 238000004587 chromatography analysis Methods 0.000 description 2
• 210000000349 chromosome Anatomy 0.000 description 2
• 229960002376 chymotrypsin Drugs 0.000 description 2
• 239000000084 colloidal system Substances 0.000 description 2
• 238000009833 condensation Methods 0.000 description 2
• 230000005494 condensation Effects 0.000 description 2
• 229910001431 copper ion Inorganic materials 0.000 description 2
• 239000006071 cream Substances 0.000 description 2
• 239000003431 cross linking reagent Substances 0.000 description 2
• 229960004643 cupric oxide Drugs 0.000 description 2
• 230000006378 damage Effects 0.000 description 2
• 239000008367 deionised water Substances 0.000 description 2
• 229910021641 deionized water Inorganic materials 0.000 description 2
• 229950006137 dexfosfoserine Drugs 0.000 description 2
• 235000021186 dishes Nutrition 0.000 description 2
• 229960003638 dopamine Drugs 0.000 description 2
• 238000004520 electroporation Methods 0.000 description 2
• 238000011067 equilibration Methods 0.000 description 2
• 241001233957 eudicotyledons Species 0.000 description 2
• 239000011536 extraction buffer Substances 0.000 description 2
• 210000002950 fibroblast Anatomy 0.000 description 2
• 239000012467 final product Substances 0.000 description 2
• 239000012530 fluid Substances 0.000 description 2
• 239000011888 foil Substances 0.000 description 2
• 125000000524 functional group Chemical group 0.000 description 2
• 239000008273 gelatin Substances 0.000 description 2
• 229920000159 gelatin Polymers 0.000 description 2
• 235000019322 gelatine Nutrition 0.000 description 2
• 235000011852 gelatine desserts Nutrition 0.000 description 2
• AZKVWQKMDGGDSV-UHFFFAOYSA-N genipin Natural products COC(=O)C1=COC(O)C2C(CO)=CCC12 AZKVWQKMDGGDSV-UHFFFAOYSA-N 0.000 description 2
• RWSXRVCMGQZWBV-WDSKDSINSA-N glutathione Chemical compound OC(=O)[C@@H](N)CCC(=O)N[C@@H](CS)C(=O)NCC(O)=O RWSXRVCMGQZWBV-WDSKDSINSA-N 0.000 description 2
• 230000035876 healing Effects 0.000 description 2
• 229960002897 heparin Drugs 0.000 description 2
• 229920000669 heparin Polymers 0.000 description 2
• 230000002209 hydrophobic effect Effects 0.000 description 2
• 230000005847 immunogenicity Effects 0.000 description 2
• 238000002513 implantation Methods 0.000 description 2
• 230000001976 improved effect Effects 0.000 description 2
• 230000001939 inductive effect Effects 0.000 description 2
• 239000012678 infectious agent Substances 0.000 description 2
• 230000000977 initiatory effect Effects 0.000 description 2
• 239000007972 injectable composition Substances 0.000 description 2
• 238000011081 inoculation Methods 0.000 description 2
• 230000010354 integration Effects 0.000 description 2
• 150000002500 ions Chemical class 0.000 description 2
• 230000002427 irreversible effect Effects 0.000 description 2
• BPHPUYQFMNQIOC-NXRLNHOXSA-N isopropyl beta-D-thiogalactopyranoside Chemical compound CC(C)S[C@@H]1O[C@H](CO)[C@H](O)[C@H](O)[C@H]1O BPHPUYQFMNQIOC-NXRLNHOXSA-N 0.000 description 2
• 239000004816 latex Substances 0.000 description 2
• 229920000126 latex Polymers 0.000 description 2
• 210000004749 ligamentum flavum Anatomy 0.000 description 2
• 238000001638 lipofection Methods 0.000 description 2
• 238000011068 loading method Methods 0.000 description 2
• 230000007246 mechanism Effects 0.000 description 2
• 230000001404 mediated effect Effects 0.000 description 2
• 210000004379 membrane Anatomy 0.000 description 2
• 239000012528 membrane Substances 0.000 description 2
• 229910021645 metal ion Inorganic materials 0.000 description 2
• 230000037230 mobility Effects 0.000 description 2
• 238000012544 monitoring process Methods 0.000 description 2
• 229910052757 nitrogen Inorganic materials 0.000 description 2
• 239000003921 oil Substances 0.000 description 2
• 235000019198 oils Nutrition 0.000 description 2
• 239000013307 optical fiber Substances 0.000 description 2
• 239000001301 oxygen Substances 0.000 description 2
• 238000007911 parenteral administration Methods 0.000 description 2
• 230000036961 partial effect Effects 0.000 description 2
• YBYRMVIVWMBXKQ-UHFFFAOYSA-N phenylmethanesulfonyl fluoride Chemical compound FS(=O)(=O)CC1=CC=CC=C1 YBYRMVIVWMBXKQ-UHFFFAOYSA-N 0.000 description 2
• BZQFBWGGLXLEPQ-REOHCLBHSA-N phosphoserine Chemical compound OC(=O)[C@@H](N)COP(O)(O)=O BZQFBWGGLXLEPQ-REOHCLBHSA-N 0.000 description 2
• 229920006210 poly(glycolide-co-caprolactone) Polymers 0.000 description 2
• 229920000747 poly(lactic acid) Polymers 0.000 description 2
• 229920001606 poly(lactic acid-co-glycolic acid) Polymers 0.000 description 2
• 229920001306 poly(lactide-co-caprolactone) Polymers 0.000 description 2
• 229920000728 polyester Polymers 0.000 description 2
• 229920001155 polypropylene Polymers 0.000 description 2
• 229920002635 polyurethane Polymers 0.000 description 2
• 239000004814 polyurethane Substances 0.000 description 2
• 230000001915 proofreading effect Effects 0.000 description 2
• 235000019419 proteases Nutrition 0.000 description 2
• 238000001742 protein purification Methods 0.000 description 2
• 150000003254 radicals Chemical class 0.000 description 2
• ZAHRKKWIAAJSAO-UHFFFAOYSA-N rapamycin Natural products COCC(O)C(=C/C(C)C(=O)CC(OC(=O)C1CCCCN1C(=O)C(=O)C2(O)OC(CC(OC)C(=CC=CC=CC(C)CC(C)C(=O)C)C)CCC2C)C(C)CC3CCC(O)C(C3)OC)C ZAHRKKWIAAJSAO-UHFFFAOYSA-N 0.000 description 2
• 239000000376 reactant Substances 0.000 description 2
• 108020003175 receptors Proteins 0.000 description 2
• 102000005962 receptors Human genes 0.000 description 2
• 230000009467 reduction Effects 0.000 description 2
• 230000010076 replication Effects 0.000 description 2
• 238000011160 research Methods 0.000 description 2
• 238000010839 reverse transcription Methods 0.000 description 2
• 238000003757 reverse transcription PCR Methods 0.000 description 2
• 235000009566 rice Nutrition 0.000 description 2
• 239000012488 sample solution Substances 0.000 description 2
• 230000028327 secretion Effects 0.000 description 2
• 229960002930 sirolimus Drugs 0.000 description 2
• JQWHASGSAFIOCM-UHFFFAOYSA-M sodium periodate Chemical compound [Na+].[O-]I(=O)(=O)=O JQWHASGSAFIOCM-UHFFFAOYSA-M 0.000 description 2
• 238000005063 solubilization Methods 0.000 description 2
• 230000007928 solubilization Effects 0.000 description 2
• 210000001082 somatic cell Anatomy 0.000 description 2
• 238000002336 sorption--desorption measurement Methods 0.000 description 2
• 108010028210 spidroin 1 Proteins 0.000 description 2
• 108010028203 spidroin 2 Proteins 0.000 description 2
• 238000013112 stability test Methods 0.000 description 2
• 239000003381 stabilizer Substances 0.000 description 2
• 230000035882 stress Effects 0.000 description 2
• 150000008163 sugars Chemical class 0.000 description 2
• 239000003826 tablet Substances 0.000 description 2
• 238000011191 terminal modification Methods 0.000 description 2
• 230000001225 therapeutic effect Effects 0.000 description 2
• 238000004448 titration Methods 0.000 description 2
• 238000001890 transfection Methods 0.000 description 2
• 238000000108 ultra-filtration Methods 0.000 description 2
• 235000015112 vegetable and seed oil Nutrition 0.000 description 2
• 239000008158 vegetable oil Substances 0.000 description 2
• 230000002861 ventricular Effects 0.000 description 2
• 230000009385 viral infection Effects 0.000 description 2
• 210000001835 viscera Anatomy 0.000 description 2
• 239000011782 vitamin Substances 0.000 description 2
• 229930003231 vitamin Natural products 0.000 description 2
• 235000013343 vitamin Nutrition 0.000 description 2
• 229940088594 vitamin Drugs 0.000 description 2
• DIGQNXIGRZPYDK-WKSCXVIASA-N (2R)-6-amino-2-[[2-[[(2S)-2-[[2-[[(2R)-2-[[(2S)-2-[[(2R,3S)-2-[[2-[[(2S)-2-[[2-[[(2S)-2-[[(2S)-2-[[(2R)-2-[[(2S,3S)-2-[[(2R)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S)-2-[[(2R)-2-[[2-[[2-[[2-[(2-amino-1-hydroxyethylidene)amino]-3-carboxy-1-hydroxypropylidene]amino]-1-hydroxy-3-sulfanylpropylidene]amino]-1-hydroxyethylidene]amino]-1-hydroxy-3-sulfanylpropylidene]amino]-1,3-dihydroxypropylidene]amino]-1-hydroxyethylidene]amino]-1-hydroxypropylidene]amino]-1,3-dihydroxypropylidene]amino]-1,3-dihydroxypropylidene]amino]-1-hydroxy-3-sulfanylpropylidene]amino]-1,3-dihydroxybutylidene]amino]-1-hydroxy-3-sulfanylpropylidene]amino]-1-hydroxypropylidene]amino]-1,3-dihydroxypropylidene]amino]-1-hydroxyethylidene]amino]-1,5-dihydroxy-5-iminopentylidene]amino]-1-hydroxy-3-sulfanylpropylidene]amino]-1,3-dihydroxybutylidene]amino]-1-hydroxy-3-sulfanylpropylidene]amino]-1,3-dihydroxypropylidene]amino]-1-hydroxyethylidene]amino]-1-hydroxy-3-sulfanylpropylidene]amino]-1-hydroxyethylidene]amino]hexanoic acid Chemical compound C[C@@H]([C@@H](C(=N[C@@H](CS)C(=N[C@@H](C)C(=N[C@@H](CO)C(=NCC(=N[C@@H](CCC(=N)O)C(=NC(CS)C(=N[C@H]([C@H](C)O)C(=N[C@H](CS)C(=N[C@H](CO)C(=NCC(=N[C@H](CS)C(=NCC(=N[C@H](CCCCN)C(=O)O)O)O)O)O)O)O)O)O)O)O)O)O)O)N=C([C@H](CS)N=C([C@H](CO)N=C([C@H](CO)N=C([C@H](C)N=C(CN=C([C@H](CO)N=C([C@H](CS)N=C(CN=C(C(CS)N=C(C(CC(=O)O)N=C(CN)O)O)O)O)O)O)O)O)O)O)O)O DIGQNXIGRZPYDK-WKSCXVIASA-N 0.000 description 1
• NMWKYTGJWUAZPZ-WWHBDHEGSA-N (4S)-4-[[(4R,7S,10S,16S,19S,25S,28S,31R)-31-[[(2S)-2-[[(1R,6R,9S,12S,18S,21S,24S,27S,30S,33S,36S,39S,42R,47R,53S,56S,59S,62S,65S,68S,71S,76S,79S,85S)-47-[[(2S)-2-[[(2S)-4-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-amino-3-methylbutanoyl]amino]-3-methylbutanoyl]amino]-3-hydroxypropanoyl]amino]-3-(1H-imidazol-4-yl)propanoyl]amino]-3-phenylpropanoyl]amino]-4-oxobutanoyl]amino]-3-carboxypropanoyl]amino]-18-(4-aminobutyl)-27,68-bis(3-amino-3-oxopropyl)-36,71,76-tribenzyl-39-(3-carbamimidamidopropyl)-24-(2-carboxyethyl)-21,56-bis(carboxymethyl)-65,85-bis[(1R)-1-hydroxyethyl]-59-(hydroxymethyl)-62,79-bis(1H-imidazol-4-ylmethyl)-9-methyl-33-(2-methylpropyl)-8,11,17,20,23,26,29,32,35,38,41,48,54,57,60,63,66,69,72,74,77,80,83,86-tetracosaoxo-30-propan-2-yl-3,4,44,45-tetrathia-7,10,16,19,22,25,28,31,34,37,40,49,55,58,61,64,67,70,73,75,78,81,84,87-tetracosazatetracyclo[40.31.14.012,16.049,53]heptaoctacontane-6-carbonyl]amino]-3-methylbutanoyl]amino]-7-(3-carbamimidamidopropyl)-25-(hydroxymethyl)-19-[(4-hydroxyphenyl)methyl]-28-(1H-imidazol-4-ylmethyl)-10-methyl-6,9,12,15,18,21,24,27,30-nonaoxo-16-propan-2-yl-1,2-dithia-5,8,11,14,17,20,23,26,29-nonazacyclodotriacontane-4-carbonyl]amino]-5-[[(2S)-1-[[(2S)-1-[[(2S)-3-carboxy-1-[[(2S)-1-[[(2S)-1-[[(1S)-1-carboxyethyl]amino]-4-methyl-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-1-oxopropan-2-yl]amino]-1-oxopropan-2-yl]amino]-3-(1H-imidazol-4-yl)-1-oxopropan-2-yl]amino]-5-oxopentanoic acid Chemical compound CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H]1CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H]2CSSC[C@@H]3NC(=O)[C@H](Cc4ccccc4)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc4c[nH]cn4)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H]4CCCN4C(=O)[C@H](CSSC[C@H](NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](Cc4c[nH]cn4)NC(=O)[C@H](Cc4ccccc4)NC3=O)[C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc3ccccc3)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N3CCC[C@H]3C(=O)N[C@@H](C)C(=O)N2)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H](N)C(C)C)C(C)C)[C@@H](C)O)C(C)C)C(=O)N[C@@H](Cc2c[nH]cn2)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1)C(=O)N[C@@H](C)C(O)=O NMWKYTGJWUAZPZ-WWHBDHEGSA-N 0.000 description 1
• PUDHBTGHUJUUFI-SCTWWAJVSA-N (4r,7s,10s,13r,16s,19r)-10-(4-aminobutyl)-n-[(2s,3r)-1-amino-3-hydroxy-1-oxobutan-2-yl]-19-[[(2r)-2-amino-3-naphthalen-2-ylpropanoyl]amino]-16-[(4-hydroxyphenyl)methyl]-13-(1h-indol-3-ylmethyl)-6,9,12,15,18-pentaoxo-7-propan-2-yl-1,2-dithia-5,8,11,14,17-p Chemical compound C([C@H]1C(=O)N[C@H](CC=2C3=CC=CC=C3NC=2)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(N[C@@H](CSSC[C@@H](C(=O)N1)NC(=O)[C@H](N)CC=1C=C2C=CC=CC2=CC=1)C(=O)N[C@@H]([C@@H](C)O)C(N)=O)=O)C(C)C)C1=CC=C(O)C=C1 PUDHBTGHUJUUFI-SCTWWAJVSA-N 0.000 description 1
• BWKMGYQJPOAASG-UHFFFAOYSA-N 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid Chemical compound C1=CC=C2CNC(C(=O)O)CC2=C1 BWKMGYQJPOAASG-UHFFFAOYSA-N 0.000 description 1
• DDMOUSALMHHKOS-UHFFFAOYSA-N 1,2-dichloro-1,1,2,2-tetrafluoroethane Chemical compound FC(F)(Cl)C(F)(F)Cl DDMOUSALMHHKOS-UHFFFAOYSA-N 0.000 description 1
• ASOKPJOREAFHNY-UHFFFAOYSA-N 1-Hydroxybenzotriazole Chemical compound C1=CC=C2N(O)N=NC2=C1 ASOKPJOREAFHNY-UHFFFAOYSA-N 0.000 description 1
• XOQABDOICLHPIS-UHFFFAOYSA-N 1-hydroxy-2,1-benzoxaborole Chemical compound C1=CC=C2B(O)OCC2=C1 XOQABDOICLHPIS-UHFFFAOYSA-N 0.000 description 1
• PJUPKRYGDFTMTM-UHFFFAOYSA-N 1-hydroxybenzotriazole;hydrate Chemical compound O.C1=CC=C2N(O)N=NC2=C1 PJUPKRYGDFTMTM-UHFFFAOYSA-N 0.000 description 1
• FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 description 1
• 108020005345 3' Untranslated Regions Proteins 0.000 description 1
• GOLORTLGFDVFDW-UHFFFAOYSA-N 3-(1h-benzimidazol-2-yl)-7-(diethylamino)chromen-2-one Chemical compound C1=CC=C2NC(C3=CC4=CC=C(C=C4OC3=O)N(CC)CC)=NC2=C1 GOLORTLGFDVFDW-UHFFFAOYSA-N 0.000 description 1
• FPQQSJJWHUJYPU-UHFFFAOYSA-N 3-(dimethylamino)propyliminomethylidene-ethylazanium;chloride Chemical compound Cl.CCN=C=NCCCN(C)C FPQQSJJWHUJYPU-UHFFFAOYSA-N 0.000 description 1
• ZIUYHTQZEPDUCZ-UHFFFAOYSA-N 7h-pyrrolo[2,3-h]quinoline Chemical compound C1=CN=C2C(C=CN3)=C3C=CC2=C1 ZIUYHTQZEPDUCZ-UHFFFAOYSA-N 0.000 description 1
• 102100032292 A disintegrin and metalloproteinase with thrombospondin motifs 17 Human genes 0.000 description 1
• 108091005674 ADAMTS17 Proteins 0.000 description 1
• 240000004507 Abelmoschus esculentus Species 0.000 description 1
• 241000208140 Acer Species 0.000 description 1
• 244000235858 Acetobacter xylinum Species 0.000 description 1
• 235000002837 Acetobacter xylinum Nutrition 0.000 description 1
• 241000254032 Acrididae Species 0.000 description 1
• 241000219068 Actinidia Species 0.000 description 1
• 241000157282 Aesculus Species 0.000 description 1
• 241000592335 Agathis australis Species 0.000 description 1
• 241000589158 Agrobacterium Species 0.000 description 1
• 241000589155 Agrobacterium tumefaciens Species 0.000 description 1
• 241000524150 Albizia amara Species 0.000 description 1
• 244000291564 Allium cepa Species 0.000 description 1
• 235000002732 Allium cepa var. cepa Nutrition 0.000 description 1
• 235000019489 Almond oil Nutrition 0.000 description 1
• 241000962146 Alsophila tricolor Species 0.000 description 1
• 241001237961 Amanita rubescens Species 0.000 description 1
• 241000219318 Amaranthus Species 0.000 description 1
• 102000004400 Aminopeptidases Human genes 0.000 description 1
• 108090000915 Aminopeptidases Proteins 0.000 description 1
• 241000744007 Andropogon Species 0.000 description 1
• 206010002329 Aneurysm Diseases 0.000 description 1
• 240000007087 Apium graveolens Species 0.000 description 1
• 235000015849 Apium graveolens Dulce Group Nutrition 0.000 description 1
• 235000010591 Appio Nutrition 0.000 description 1
• 235000003911 Arachis Nutrition 0.000 description 1
• 244000105624 Arachis hypogaea Species 0.000 description 1
• 241000239223 Arachnida Species 0.000 description 1
• 244000080767 Areca catechu Species 0.000 description 1
• IYMAXBFPHPZYIK-BQBZGAKWSA-N Arg-Gly-Asp Chemical compound NC(N)=NCCC[C@H](N)C(=O)NCC(=O)N[C@@H](CC(O)=O)C(O)=O IYMAXBFPHPZYIK-BQBZGAKWSA-N 0.000 description 1
• 229920002955 Art silk Polymers 0.000 description 1
• 241000222211 Arthromyces Species 0.000 description 1
• 108010000241 Arthropod Proteins Proteins 0.000 description 1
• 102000035101 Aspartic proteases Human genes 0.000 description 1
• 108091005502 Aspartic proteases Proteins 0.000 description 1
• BSYNRYMUTXBXSQ-UHFFFAOYSA-N Aspirin Chemical compound CC(=O)OC1=CC=CC=C1C(O)=O BSYNRYMUTXBXSQ-UHFFFAOYSA-N 0.000 description 1
• 241000257469 Asterias Species 0.000 description 1
• 241001061305 Astragalus cicer Species 0.000 description 1
• XUKUURHRXDUEBC-KAYWLYCHSA-N Atorvastatin Chemical compound C=1C=CC=CC=1C1=C(C=2C=CC(F)=CC=2)N(CC[C@@H](O)C[C@@H](O)CC(O)=O)C(C(C)C)=C1C(=O)NC1=CC=CC=C1 XUKUURHRXDUEBC-KAYWLYCHSA-N 0.000 description 1
• XUKUURHRXDUEBC-UHFFFAOYSA-N Atorvastatin Natural products C=1C=CC=CC=1C1=C(C=2C=CC(F)=CC=2)N(CCC(O)CC(O)CC(O)=O)C(C(C)C)=C1C(=O)NC1=CC=CC=C1 XUKUURHRXDUEBC-UHFFFAOYSA-N 0.000 description 1
• 239000005552 B01AC04 - Clopidogrel Substances 0.000 description 1
• 235000014469 Bacillus subtilis Nutrition 0.000 description 1
• 241000012950 Baikiaea plurijuga Species 0.000 description 1
• 101710172784 Basic endochitinase B Proteins 0.000 description 1
• 241000219310 Beta vulgaris subsp. vulgaris Species 0.000 description 1
• 102400001362 Beta-thromboglobulin Human genes 0.000 description 1
• 101800003265 Beta-thromboglobulin Proteins 0.000 description 1
• 239000002028 Biomass Substances 0.000 description 1
• 241000255791 Bombyx Species 0.000 description 1
• 102000007350 Bone Morphogenetic Proteins Human genes 0.000 description 1
• 108010007726 Bone Morphogenetic Proteins Proteins 0.000 description 1
• 241000701822 Bovine papillomavirus Species 0.000 description 1
• 235000011331 Brassica Nutrition 0.000 description 1
• 241000219198 Brassica Species 0.000 description 1
• 240000007124 Brassica oleracea Species 0.000 description 1
• 235000003899 Brassica oleracea var acephala Nutrition 0.000 description 1
• 235000011299 Brassica oleracea var botrytis Nutrition 0.000 description 1
• 244000064816 Brassica oleracea var. acephala Species 0.000 description 1
• 240000003259 Brassica oleracea var. botrytis Species 0.000 description 1
• 206010006187 Breast cancer Diseases 0.000 description 1
• 241001534925 Bruguiera Species 0.000 description 1
• 241001424028 Burkea africana Species 0.000 description 1
• 241000565319 Butea monosperma Species 0.000 description 1
• QRABSTLMZWUWIQ-UHFFFAOYSA-N CSCP Chemical compound CSCP QRABSTLMZWUWIQ-UHFFFAOYSA-N 0.000 description 1
• 241001167712 Cadaba Species 0.000 description 1
• 241000628166 Cadaba farinosa Species 0.000 description 1
• 102000000905 Cadherin Human genes 0.000 description 1
• 108050007957 Cadherin Proteins 0.000 description 1
• 241000244203 Caenorhabditis elegans Species 0.000 description 1
• 101100297347 Caenorhabditis elegans pgl-3 gene Proteins 0.000 description 1
• 101100408682 Caenorhabditis elegans pmt-2 gene Proteins 0.000 description 1
• 241000282472 Canis lupus familiaris Species 0.000 description 1
• 235000002566 Capsicum Nutrition 0.000 description 1
• 240000008574 Capsicum frutescens Species 0.000 description 1
• OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
• 229920000049 Carbon (fiber) Polymers 0.000 description 1
• 102000005367 Carboxypeptidases Human genes 0.000 description 1
• 108010006303 Carboxypeptidases Proteins 0.000 description 1
• 241000701489 Cauliflower mosaic virus Species 0.000 description 1
• 229920003043 Cellulose fiber Polymers 0.000 description 1
• 235000006295 Chrysanthemum sp Nutrition 0.000 description 1
• 241000974977 Chrysanthemum sp. Species 0.000 description 1
• 206010053567 Coagulopathies Diseases 0.000 description 1
• 241000254173 Coleoptera Species 0.000 description 1
• 102000012422 Collagen Type I Human genes 0.000 description 1
• 108010022452 Collagen Type I Proteins 0.000 description 1
• 241000349997 Colophospermum Species 0.000 description 1
• 241000350000 Colophospermum mopane Species 0.000 description 1
• 108010062580 Concanavalin A Proteins 0.000 description 1
• 239000004971 Cross linker Substances 0.000 description 1
• 240000005109 Cryptomeria japonica Species 0.000 description 1
• 241000195493 Cryptophyta Species 0.000 description 1
• 235000010071 Cucumis prophetarum Nutrition 0.000 description 1
• 244000024469 Cucumis prophetarum Species 0.000 description 1
• 235000009854 Cucurbita moschata Nutrition 0.000 description 1
• 240000001980 Cucurbita pepo Species 0.000 description 1
• 235000009852 Cucurbita pepo Nutrition 0.000 description 1
• 241000723198 Cupressus Species 0.000 description 1
• 241000132493 Cyathea dealbata Species 0.000 description 1
• PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical compound CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 description 1
• 108010036949 Cyclosporine Proteins 0.000 description 1
• 244000236931 Cydonia oblonga Species 0.000 description 1
• 102000004127 Cytokines Human genes 0.000 description 1
• 108090000695 Cytokines Proteins 0.000 description 1
• GUBGYTABKSRVRQ-CUHNMECISA-N D-Cellobiose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)OC(O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-CUHNMECISA-N 0.000 description 1
• FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 1
• 150000008574 D-amino acids Chemical class 0.000 description 1
• ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 description 1
• FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 1
• 102000053602 DNA Human genes 0.000 description 1
• 238000007400 DNA extraction Methods 0.000 description 1
• 102000004163 DNA-directed RNA polymerases Human genes 0.000 description 1
• 108090000626 DNA-directed RNA polymerases Proteins 0.000 description 1
• 241000746417 Dalbergia monetaria Species 0.000 description 1
• 244000000626 Daucus carota Species 0.000 description 1
• 235000002767 Daucus carota Nutrition 0.000 description 1
• 241000035389 Davallia divaricata Species 0.000 description 1
• XMSXQFUHVRWGNA-UHFFFAOYSA-N Decamethylcyclopentasiloxane Chemical compound C[Si]1(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O1 XMSXQFUHVRWGNA-UHFFFAOYSA-N 0.000 description 1
• 241000522190 Desmodium Species 0.000 description 1
• 206010056340 Diabetic ulcer Diseases 0.000 description 1
• 239000004338 Dichlorodifluoromethane Substances 0.000 description 1
• 241000196119 Dicksonia Species 0.000 description 1
• 241000219764 Dolichos Species 0.000 description 1
• 241000255581 Drosophila <fruit fly, genus> Species 0.000 description 1
• 241000255601 Drosophila melanogaster Species 0.000 description 1
• 101100278667 Drosophila melanogaster Duox gene Proteins 0.000 description 1
• 101100033694 Drosophila melanogaster resilin gene Proteins 0.000 description 1
• 241000628129 Echinochloa pyramidalis Species 0.000 description 1
• 241000257465 Echinoidea Species 0.000 description 1
• LVGKNOAMLMIIKO-UHFFFAOYSA-N Elaidinsaeure-aethylester Natural products CCCCCCCCC=CCCCCCCCC(=O)OCC LVGKNOAMLMIIKO-UHFFFAOYSA-N 0.000 description 1
• 235000007349 Eleusine coracana Nutrition 0.000 description 1
• 244000078127 Eleusine coracana Species 0.000 description 1
• 102400000792 Endothelial monocyte-activating polypeptide 2 Human genes 0.000 description 1
• 241000792859 Enema Species 0.000 description 1
• 108010013369 Enteropeptidase Proteins 0.000 description 1
• 102100029727 Enteropeptidase Human genes 0.000 description 1
• 102400001368 Epidermal growth factor Human genes 0.000 description 1
• 101800003838 Epidermal growth factor Proteins 0.000 description 1
• 241000283086 Equidae Species 0.000 description 1
• 102000003951 Erythropoietin Human genes 0.000 description 1
• 108090000394 Erythropoietin Proteins 0.000 description 1
• 241001671330 Euclea <angiosperm> Species 0.000 description 1
• 241000206602 Eukaryota Species 0.000 description 1
• 108091029865 Exogenous DNA Proteins 0.000 description 1
• 244000233576 Feijoa sellowiana Species 0.000 description 1
• 235000012068 Feijoa sellowiana Nutrition 0.000 description 1
• 108010073385 Fibrin Proteins 0.000 description 1
• 102000009123 Fibrin Human genes 0.000 description 1
• BWGVNKXGVNDBDI-UHFFFAOYSA-N Fibrin monomer Chemical compound CNC(=O)CNC(=O)CN BWGVNKXGVNDBDI-UHFFFAOYSA-N 0.000 description 1
• 108010049003 Fibrinogen Proteins 0.000 description 1
• 102000008946 Fibrinogen Human genes 0.000 description 1
• 241001022083 Flemingia Species 0.000 description 1
• 241000220223 Fragaria Species 0.000 description 1
• 241000169596 Freycinetia Species 0.000 description 1
• 241000233866 Fungi Species 0.000 description 1
• 244000105059 Geranium thunbergii Species 0.000 description 1
• 235000005491 Geranium thunbergii Nutrition 0.000 description 1
• 108010073178 Glucan 1,4-alpha-Glucosidase Proteins 0.000 description 1
• 102100022624 Glucoamylase Human genes 0.000 description 1
• WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
• 108010051815 Glutamyl endopeptidase Proteins 0.000 description 1
• 108010024636 Glutathione Proteins 0.000 description 1
• 235000010469 Glycine max Nutrition 0.000 description 1
• 244000068988 Glycine max Species 0.000 description 1
• 108010017080 Granulocyte Colony-Stimulating Factor Proteins 0.000 description 1
• 102000004269 Granulocyte Colony-Stimulating Factor Human genes 0.000 description 1
• 241001648387 Grevillea Species 0.000 description 1
• 241000013479 Guibourtia coleosperma Species 0.000 description 1
• 241000214032 Hedysarum Species 0.000 description 1
• 244000020551 Helianthus annuus Species 0.000 description 1
• 235000003222 Helianthus annuus Nutrition 0.000 description 1
• 229920002488 Hemicellulose Polymers 0.000 description 1
• 241001582739 Heteropogon <robber fly> Species 0.000 description 1
• 229910052689 Holmium Inorganic materials 0.000 description 1
• 108010001336 Horseradish Peroxidase Proteins 0.000 description 1
• 241000701044 Human gammaherpesvirus 4 Species 0.000 description 1
• UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 1
• LCWXJXMHJVIJFK-UHFFFAOYSA-N Hydroxylysine Natural products NCC(O)CC(N)CC(O)=O LCWXJXMHJVIJFK-UHFFFAOYSA-N 0.000 description 1
• PMMYEEVYMWASQN-DMTCNVIQSA-N Hydroxyproline Chemical compound O[C@H]1CN[C@H](C(O)=O)C1 PMMYEEVYMWASQN-DMTCNVIQSA-N 0.000 description 1
• 244000284937 Hyparrhenia rufa Species 0.000 description 1
• 241000782597 Hypericum erectum Species 0.000 description 1
• 235000017309 Hypericum perforatum Nutrition 0.000 description 1
• 244000141009 Hypericum perforatum Species 0.000 description 1
• 241000221931 Hypomyces rosellus Species 0.000 description 1
• 235000000177 Indigofera tinctoria Nutrition 0.000 description 1
• 206010061218 Inflammation Diseases 0.000 description 1
• 108090000723 Insulin-Like Growth Factor I Proteins 0.000 description 1
• 108090001117 Insulin-Like Growth Factor II Proteins 0.000 description 1
• 102100025947 Insulin-like growth factor II Human genes 0.000 description 1
• 102100034343 Integrase Human genes 0.000 description 1
• 102000003996 Interferon-beta Human genes 0.000 description 1
• 108090000467 Interferon-beta Proteins 0.000 description 1
• 102000003814 Interleukin-10 Human genes 0.000 description 1
• 108090000174 Interleukin-10 Proteins 0.000 description 1
• SNDPXSYFESPGGJ-BYPYZUCNSA-N L-2-aminopentanoic acid Chemical compound CCC[C@H](N)C(O)=O SNDPXSYFESPGGJ-BYPYZUCNSA-N 0.000 description 1
• AHLPHDHHMVZTML-BYPYZUCNSA-N L-Ornithine Chemical compound NCCC[C@H](N)C(O)=O AHLPHDHHMVZTML-BYPYZUCNSA-N 0.000 description 1
• QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 description 1
• ZGUNAGUHMKGQNY-ZETCQYMHSA-N L-alpha-phenylglycine zwitterion Chemical compound OC(=O)[C@@H](N)C1=CC=CC=C1 ZGUNAGUHMKGQNY-ZETCQYMHSA-N 0.000 description 1
• 150000008575 L-amino acids Chemical class 0.000 description 1
• CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 description 1
• AGPKZVBTJJNPAG-WHFBIAKZSA-N L-isoleucine Chemical compound CC[C@H](C)[C@H](N)C(O)=O AGPKZVBTJJNPAG-WHFBIAKZSA-N 0.000 description 1
• SNDPXSYFESPGGJ-UHFFFAOYSA-N L-norVal-OH Natural products CCCC(N)C(O)=O SNDPXSYFESPGGJ-UHFFFAOYSA-N 0.000 description 1
• LRQKBLKVPFOOQJ-YFKPBYRVSA-N L-norleucine Chemical compound CCCC[C@H]([NH3+])C([O-])=O LRQKBLKVPFOOQJ-YFKPBYRVSA-N 0.000 description 1
• 125000000510 L-tryptophano group Chemical group [H]C1=C([H])C([H])=C2N([H])C([H])=C(C([H])([H])[C@@]([H])(C(O[H])=O)N([H])[*])C2=C1[H] 0.000 description 1
• 235000014647 Lens culinaris subsp culinaris Nutrition 0.000 description 1
• 244000043158 Lens esculenta Species 0.000 description 1
• 241000209510 Liliopsida Species 0.000 description 1
• 235000004431 Linum usitatissimum Nutrition 0.000 description 1
• 240000006240 Linum usitatissimum Species 0.000 description 1
• 235000007688 Lycopersicon esculentum Nutrition 0.000 description 1
• KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 description 1
• 239000004472 Lysine Substances 0.000 description 1
• 102000007651 Macrophage Colony-Stimulating Factor Human genes 0.000 description 1
• 108010046938 Macrophage Colony-Stimulating Factor Proteins 0.000 description 1
• 241000219822 Macrotyloma axillare Species 0.000 description 1
• 241000220225 Malus Species 0.000 description 1
• 241000124008 Mammalia Species 0.000 description 1
• 235000004456 Manihot esculenta Nutrition 0.000 description 1
• 235000016735 Manihot esculenta subsp esculenta Nutrition 0.000 description 1
• 235000017587 Medicago sativa ssp. sativa Nutrition 0.000 description 1
• 108010006035 Metalloproteases Proteins 0.000 description 1
• 102000005741 Metalloproteases Human genes 0.000 description 1
• 102000003792 Metallothionein Human genes 0.000 description 1
• 108090000157 Metallothionein Proteins 0.000 description 1
• CERQOIWHTDAKMF-UHFFFAOYSA-M Methacrylate Chemical compound CC(=C)C([O-])=O CERQOIWHTDAKMF-UHFFFAOYSA-M 0.000 description 1
• 102000009664 Microtubule-Associated Proteins Human genes 0.000 description 1
• 108010020004 Microtubule-Associated Proteins Proteins 0.000 description 1
• 241000713862 Moloney murine sarcoma virus Species 0.000 description 1
• 241001529936 Murinae Species 0.000 description 1
• 241000714177 Murine leukemia virus Species 0.000 description 1
• 101001047513 Mus musculus Lethal(2) giant larvae protein homolog 1 Proteins 0.000 description 1
• NQTADLQHYWFPDB-UHFFFAOYSA-N N-Hydroxysuccinimide Chemical compound ON1C(=O)CCC1=O NQTADLQHYWFPDB-UHFFFAOYSA-N 0.000 description 1
• 229910019093 NaOCl Inorganic materials 0.000 description 1
• 235000006508 Nelumbo nucifera Nutrition 0.000 description 1
• 240000002853 Nelumbo nucifera Species 0.000 description 1
• 235000006510 Nelumbo pentapetala Nutrition 0.000 description 1
• 241000238903 Nephila Species 0.000 description 1
• 102100027889 Ninjurin-2 Human genes 0.000 description 1
• 101710091555 Ninjurin-2 Proteins 0.000 description 1
• 241000238633 Odonata Species 0.000 description 1
• 108091034117 Oligonucleotide Proteins 0.000 description 1
• 241000219830 Onobrychis Species 0.000 description 1
• AHLPHDHHMVZTML-UHFFFAOYSA-N Orn-delta-NH2 Natural products NCCCC(N)C(O)=O AHLPHDHHMVZTML-UHFFFAOYSA-N 0.000 description 1
• UTJLXEIPEHZYQJ-UHFFFAOYSA-N Ornithine Natural products OC(=O)C(C)CCCN UTJLXEIPEHZYQJ-UHFFFAOYSA-N 0.000 description 1
• 241001446528 Ornithopus Species 0.000 description 1
• 102000004316 Oxidoreductases Human genes 0.000 description 1
• 108090000854 Oxidoreductases Proteins 0.000 description 1
• 208000034530 PLAA-associated neurodevelopmental disease Diseases 0.000 description 1
• 229910019142 PO4 Inorganic materials 0.000 description 1
• 229930012538 Paclitaxel Natural products 0.000 description 1
• 241001618237 Peltophorum africanum Species 0.000 description 1
• 241000209046 Pennisetum Species 0.000 description 1
• 102000057297 Pepsin A Human genes 0.000 description 1
• 108090000284 Pepsin A Proteins 0.000 description 1
• 102000002508 Peptide Elongation Factors Human genes 0.000 description 1
• 108010068204 Peptide Elongation Factors Proteins 0.000 description 1
• 108010043958 Peptoids Proteins 0.000 description 1
• 240000007377 Petunia x hybrida Species 0.000 description 1
• 241000219833 Phaseolus Species 0.000 description 1
• 235000015867 Phoenix canariensis Nutrition 0.000 description 1
• 241001092035 Photinia Species 0.000 description 1
• 241000218657 Picea Species 0.000 description 1
• 240000000020 Picea glauca Species 0.000 description 1
• 235000008127 Picea glauca Nutrition 0.000 description 1
• 241000235648 Pichia Species 0.000 description 1
• 108010038512 Platelet-Derived Growth Factor Proteins 0.000 description 1
• 102000010780 Platelet-Derived Growth Factor Human genes 0.000 description 1
• 235000018794 Podocarpus totara Nutrition 0.000 description 1
• 240000003145 Podocarpus totara Species 0.000 description 1
• 229920003171 Poly (ethylene oxide) Polymers 0.000 description 1
• 239000004952 Polyamide Substances 0.000 description 1
• 239000004698 Polyethylene Substances 0.000 description 1
• 229920002565 Polyethylene Glycol 400 Polymers 0.000 description 1
• 239000002202 Polyethylene glycol Substances 0.000 description 1
• 101710182846 Polyhedrin Proteins 0.000 description 1
• 229920001273 Polyhydroxy acid Polymers 0.000 description 1
• 108010039918 Polylysine Proteins 0.000 description 1
• 241001505332 Polyomavirus sp. Species 0.000 description 1
• 229920002396 Polyurea Polymers 0.000 description 1
• 101710161649 Pro-resilin Proteins 0.000 description 1
• 108010050808 Procollagen Proteins 0.000 description 1
• 108700015930 Prolyl Oligopeptidases Proteins 0.000 description 1
• 102000056251 Prolyl Oligopeptidases Human genes 0.000 description 1
• 241001494501 Prosopis <angiosperm> Species 0.000 description 1
• 229940124158 Protease/peptidase inhibitor Drugs 0.000 description 1
• 108010003894 Protein-Lysine 6-Oxidase Proteins 0.000 description 1
• 102100026858 Protein-lysine 6-oxidase Human genes 0.000 description 1
• 235000008572 Pseudotsuga menziesii Nutrition 0.000 description 1
• 240000001416 Pseudotsuga menziesii Species 0.000 description 1
• 241000382353 Pupa Species 0.000 description 1
• 235000014443 Pyrus communis Nutrition 0.000 description 1
• 240000001987 Pyrus communis Species 0.000 description 1
• 230000006819 RNA synthesis Effects 0.000 description 1
• 244000171263 Ribes grossularia Species 0.000 description 1
• 235000002357 Ribes grossularia Nutrition 0.000 description 1
• 235000010101 Ribes sp Nutrition 0.000 description 1
• 241001493421 Robinia <trematode> Species 0.000 description 1
• 235000011449 Rosa Nutrition 0.000 description 1
• 241001092459 Rubus Species 0.000 description 1
• 240000000111 Saccharum officinarum Species 0.000 description 1
• 235000007201 Saccharum officinarum Nutrition 0.000 description 1
• 241000124033 Salix Species 0.000 description 1
• 241001639806 Searsia natalensis Species 0.000 description 1
• 108010022999 Serine Proteases Proteins 0.000 description 1
• 102000012479 Serine Proteases Human genes 0.000 description 1
• 108020004682 Single-Stranded DNA Proteins 0.000 description 1
• 208000028990 Skin injury Diseases 0.000 description 1
• 240000003768 Solanum lycopersicum Species 0.000 description 1
• 235000002595 Solanum tuberosum Nutrition 0.000 description 1
• 102000013275 Somatomedins Human genes 0.000 description 1
• 241000847989 Sporobolus fimbriatus Species 0.000 description 1
• 229910000831 Steel Inorganic materials 0.000 description 1
• 241000408201 Stiburus Species 0.000 description 1
• 101710172711 Structural protein Proteins 0.000 description 1
• 235000021536 Sugar beet Nutrition 0.000 description 1
• 108010051181 TNK-tissue plasminogen activator Proteins 0.000 description 1
• QJJXYPPXXYFBGM-LFZNUXCKSA-N Tacrolimus Chemical compound C1C[C@@H](O)[C@H](OC)C[C@@H]1\C=C(/C)[C@@H]1[C@H](C)[C@@H](O)CC(=O)[C@H](CC=C)/C=C(C)/C[C@H](C)C[C@H](OC)[C@H]([C@H](C[C@H]2C)OC)O[C@@]2(O)C(=O)C(=O)N2CCCC[C@H]2C(=O)O1 QJJXYPPXXYFBGM-LFZNUXCKSA-N 0.000 description 1
• 241000505911 Tadehagi Species 0.000 description 1
• 102000007000 Tenascin Human genes 0.000 description 1
• 108010008125 Tenascin Proteins 0.000 description 1
• 244000269722 Thea sinensis Species 0.000 description 1
• 102000036693 Thrombopoietin Human genes 0.000 description 1
• 108010041111 Thrombopoietin Proteins 0.000 description 1
• 108090000373 Tissue Plasminogen Activator Proteins 0.000 description 1
• 102000003978 Tissue Plasminogen Activator Human genes 0.000 description 1
• 102400001320 Transforming growth factor alpha Human genes 0.000 description 1
• 101800004564 Transforming growth factor alpha Proteins 0.000 description 1
• 108700019146 Transgenes Proteins 0.000 description 1
• 102100032452 Transmembrane protease serine 6 Human genes 0.000 description 1
• GSNOZLZNQMLSKJ-UHFFFAOYSA-N Trapidil Chemical compound CCN(CC)C1=CC(C)=NC2=NC=NN12 GSNOZLZNQMLSKJ-UHFFFAOYSA-N 0.000 description 1
• 241000219793 Trifolium Species 0.000 description 1
• 235000021307 Triticum Nutrition 0.000 description 1
• 241000209140 Triticum Species 0.000 description 1
• 108090000631 Trypsin Proteins 0.000 description 1
• 102000004142 Trypsin Human genes 0.000 description 1
• 102100032761 Tryptase gamma Human genes 0.000 description 1
• 101710098318 Tryptase gamma Proteins 0.000 description 1
• 240000003021 Tsuga heterophylla Species 0.000 description 1
• 235000008554 Tsuga heterophylla Nutrition 0.000 description 1
• 206010046442 Urethral dilatation Diseases 0.000 description 1
• 235000012511 Vaccinium Nutrition 0.000 description 1
• 241000736767 Vaccinium Species 0.000 description 1
• 108010073929 Vascular Endothelial Growth Factor A Proteins 0.000 description 1
• 102000005789 Vascular Endothelial Growth Factors Human genes 0.000 description 1
• 108010019530 Vascular Endothelial Growth Factors Proteins 0.000 description 1
• 241000251539 Vertebrata <Metazoa> Species 0.000 description 1
• 241000219873 Vicia Species 0.000 description 1
• 108010065472 Vimentin Proteins 0.000 description 1
• 102100035071 Vimentin Human genes 0.000 description 1
• FPIPGXGPPPQFEQ-BOOMUCAASA-N Vitamin A Natural products OC/C=C(/C)\C=C\C=C(\C)/C=C/C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-BOOMUCAASA-N 0.000 description 1
• 229930003268 Vitamin C Natural products 0.000 description 1
• 229930003427 Vitamin E Natural products 0.000 description 1
• 235000014787 Vitis vinifera Nutrition 0.000 description 1
• 240000006365 Vitis vinifera Species 0.000 description 1
• 108010031318 Vitronectin Proteins 0.000 description 1
• 102100035140 Vitronectin Human genes 0.000 description 1
• 241000596981 Watsonia Species 0.000 description 1
• 240000001198 Zantedeschia aethiopica Species 0.000 description 1
• 235000007244 Zea mays Nutrition 0.000 description 1
• 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 description 1
• 235000002017 Zea mays subsp mays Nutrition 0.000 description 1
• JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 description 1
• 238000012084 abdominal surgery Methods 0.000 description 1
• 238000010521 absorption reaction Methods 0.000 description 1
• DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 description 1
• JUGOREOARAHOCO-UHFFFAOYSA-M acetylcholine chloride Chemical compound [Cl-].CC(=O)OCC[N+](C)(C)C JUGOREOARAHOCO-UHFFFAOYSA-M 0.000 description 1
• 229960001138 acetylsalicylic acid Drugs 0.000 description 1
• 230000003213 activating effect Effects 0.000 description 1
• 231100000899 acute systemic toxicity Toxicity 0.000 description 1
• 210000000577 adipose tissue Anatomy 0.000 description 1
• 239000000443 aerosol Substances 0.000 description 1
• 235000004279 alanine Nutrition 0.000 description 1
• 230000001476 alcoholic effect Effects 0.000 description 1
• 150000001299 aldehydes Chemical class 0.000 description 1
• 125000000217 alkyl group Chemical group 0.000 description 1
• FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 description 1
• 239000008168 almond oil Substances 0.000 description 1
• 239000012491 analyte Substances 0.000 description 1
• 230000003872 anastomosis Effects 0.000 description 1
• 230000002491 angiogenic effect Effects 0.000 description 1
• 210000004102 animal cell Anatomy 0.000 description 1
• 210000003423 ankle Anatomy 0.000 description 1
• 239000003242 anti bacterial agent Substances 0.000 description 1
• 230000000181 anti-adherent effect Effects 0.000 description 1
• 230000001028 anti-proliverative effect Effects 0.000 description 1
• 230000002785 anti-thrombosis Effects 0.000 description 1
• 229940088710 antibiotic agent Drugs 0.000 description 1
• 229940127090 anticoagulant agent Drugs 0.000 description 1
• 238000013459 approach Methods 0.000 description 1
• 239000008135 aqueous vehicle Substances 0.000 description 1
• 108010072041 arginyl-glycyl-aspartic acid Proteins 0.000 description 1
• 239000002473 artificial blood Substances 0.000 description 1
• 235000003704 aspartic acid Nutrition 0.000 description 1
• 108010045569 atelocollagen Proteins 0.000 description 1
• 229960005370 atorvastatin Drugs 0.000 description 1
• 230000004888 barrier function Effects 0.000 description 1
• OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 description 1
• 229920000249 biocompatible polymer Polymers 0.000 description 1
• 229920000704 biodegradable plastic Polymers 0.000 description 1
• 239000003124 biologic agent Substances 0.000 description 1
• 230000008827 biological function Effects 0.000 description 1
• 230000000740 bleeding effect Effects 0.000 description 1
• 239000008280 blood Substances 0.000 description 1
• 210000004369 blood Anatomy 0.000 description 1
• 210000000988 bone and bone Anatomy 0.000 description 1
• 229940112869 bone morphogenetic protein Drugs 0.000 description 1
• 239000001506 calcium phosphate Substances 0.000 description 1
• 229910000389 calcium phosphate Inorganic materials 0.000 description 1
• 235000011010 calcium phosphates Nutrition 0.000 description 1
• 239000001390 capsicum minimum Substances 0.000 description 1
• 239000004202 carbamide Substances 0.000 description 1
• 150000001721 carbon Chemical group 0.000 description 1
• 239000001569 carbon dioxide Substances 0.000 description 1
• 229910002092 carbon dioxide Inorganic materials 0.000 description 1
• 229960004424 carbon dioxide Drugs 0.000 description 1
• 239000004917 carbon fiber Substances 0.000 description 1
• 150000001723 carbon free-radicals Chemical class 0.000 description 1
• 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 1
• 239000000969 carrier Substances 0.000 description 1
• 239000003054 catalyst Substances 0.000 description 1
• 230000024245 cell differentiation Effects 0.000 description 1
• 230000012292 cell migration Effects 0.000 description 1
• 230000004663 cell proliferation Effects 0.000 description 1
• 229920003086 cellulose ether Polymers 0.000 description 1
• 230000008859 change Effects 0.000 description 1
• 210000001136 chorion Anatomy 0.000 description 1
• 238000011098 chromatofocusing Methods 0.000 description 1
• 229960001265 ciclosporin Drugs 0.000 description 1
• 239000013599 cloning vector Substances 0.000 description 1
• GKTWGGQPFAXNFI-HNNXBMFYSA-N clopidogrel Chemical compound C1([C@H](N2CC=3C=CSC=3CC2)C(=O)OC)=CC=CC=C1Cl GKTWGGQPFAXNFI-HNNXBMFYSA-N 0.000 description 1
• 229960003009 clopidogrel Drugs 0.000 description 1
• 230000035602 clotting Effects 0.000 description 1
• 238000005354 coacervation Methods 0.000 description 1
• 229940110456 cocoa butter Drugs 0.000 description 1
• 235000019868 cocoa butter Nutrition 0.000 description 1
• 238000004040 coloring Methods 0.000 description 1
• 238000004891 communication Methods 0.000 description 1
• 239000011365 complex material Substances 0.000 description 1
• 230000000536 complexating effect Effects 0.000 description 1
• 238000013329 compounding Methods 0.000 description 1
• 230000003750 conditioning effect Effects 0.000 description 1
• 239000002322 conducting polymer Substances 0.000 description 1
• 229920001940 conductive polymer Polymers 0.000 description 1
• 238000012790 confirmation Methods 0.000 description 1
• 239000000470 constituent Substances 0.000 description 1
• 239000013068 control sample Substances 0.000 description 1
• 238000007796 conventional method Methods 0.000 description 1
• 229920001577 copolymer Polymers 0.000 description 1
• 239000010949 copper Substances 0.000 description 1
• 235000005822 corn Nutrition 0.000 description 1
• 210000004351 coronary vessel Anatomy 0.000 description 1
• 230000008878 coupling Effects 0.000 description 1
• 238000010168 coupling process Methods 0.000 description 1
• 238000005859 coupling reaction Methods 0.000 description 1
• 229920006037 cross link polymer Polymers 0.000 description 1
• 238000012258 culturing Methods 0.000 description 1
• 238000005520 cutting process Methods 0.000 description 1
• 229940086555 cyclomethicone Drugs 0.000 description 1
• 229930182912 cyclosporin Natural products 0.000 description 1
• 230000009089 cytolysis Effects 0.000 description 1
• 230000003013 cytotoxicity Effects 0.000 description 1
• 231100000135 cytotoxicity Toxicity 0.000 description 1
• 244000195896 dadap Species 0.000 description 1
• 229960004969 dalteparin Drugs 0.000 description 1
• 230000003247 decreasing effect Effects 0.000 description 1
• 229920006237 degradable polymer Polymers 0.000 description 1
• 239000007857 degradation product Substances 0.000 description 1
• YSMODUONRAFBET-UHFFFAOYSA-N delta-DL-hydroxylysine Natural products NCC(O)CCC(N)C(O)=O YSMODUONRAFBET-UHFFFAOYSA-N 0.000 description 1
• 238000013461 design Methods 0.000 description 1
• 238000001514 detection method Methods 0.000 description 1
• 206010012601 diabetes mellitus Diseases 0.000 description 1
• 238000010586 diagram Methods 0.000 description 1
• PXBRQCKWGAHEHS-UHFFFAOYSA-N dichlorodifluoromethane Chemical compound FC(F)(Cl)Cl PXBRQCKWGAHEHS-UHFFFAOYSA-N 0.000 description 1
• 235000019404 dichlorodifluoromethane Nutrition 0.000 description 1
• 229940042935 dichlorodifluoromethane Drugs 0.000 description 1
• 229940087091 dichlorotetrafluoroethane Drugs 0.000 description 1
• 235000014113 dietary fatty acids Nutrition 0.000 description 1
• 125000005442 diisocyanate group Chemical group 0.000 description 1
• 239000003085 diluting agent Substances 0.000 description 1
• 238000010790 dilution Methods 0.000 description 1
• 239000012895 dilution Substances 0.000 description 1
• 239000000539 dimer Substances 0.000 description 1
• 229940008099 dimethicone Drugs 0.000 description 1
• 239000004205 dimethyl polysiloxane Substances 0.000 description 1
• 235000013870 dimethyl polysiloxane Nutrition 0.000 description 1
• 239000002270 dispersing agent Substances 0.000 description 1
• 238000010494 dissociation reaction Methods 0.000 description 1
• 230000005593 dissociations Effects 0.000 description 1
• 239000012153 distilled water Substances 0.000 description 1
• PMMYEEVYMWASQN-UHFFFAOYSA-N dl-hydroxyproline Natural products OC1C[NH2+]C(C([O-])=O)C1 PMMYEEVYMWASQN-UHFFFAOYSA-N 0.000 description 1
• 239000008298 dragée Substances 0.000 description 1
• 238000009510 drug design Methods 0.000 description 1
• 239000013583 drug formulation Substances 0.000 description 1
• 239000013013 elastic material Substances 0.000 description 1
• 238000001962 electrophoresis Methods 0.000 description 1
• 230000003073 embolic effect Effects 0.000 description 1
• 210000002257 embryonic structure Anatomy 0.000 description 1
• 239000003974 emollient agent Substances 0.000 description 1
• 230000001804 emulsifying effect Effects 0.000 description 1
• 239000000839 emulsion Substances 0.000 description 1
• 239000007920 enema Substances 0.000 description 1
• 229940079360 enema for constipation Drugs 0.000 description 1
• 238000004146 energy storage Methods 0.000 description 1
• 230000002708 enhancing effect Effects 0.000 description 1
• 229940116977 epidermal growth factor Drugs 0.000 description 1
• YSMODUONRAFBET-UHNVWZDZSA-N erythro-5-hydroxy-L-lysine Chemical compound NC[C@H](O)CC[C@H](N)C(O)=O YSMODUONRAFBET-UHNVWZDZSA-N 0.000 description 1
• 229940105423 erythropoietin Drugs 0.000 description 1
• LVGKNOAMLMIIKO-QXMHVHEDSA-N ethyl oleate Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OCC LVGKNOAMLMIIKO-QXMHVHEDSA-N 0.000 description 1
• 229940093471 ethyl oleate Drugs 0.000 description 1
• 239000005038 ethylene vinyl acetate Substances 0.000 description 1
• 210000002744 extracellular matrix Anatomy 0.000 description 1
• 238000000605 extraction Methods 0.000 description 1
• 230000001815 facial effect Effects 0.000 description 1
• 239000000194 fatty acid Substances 0.000 description 1
• 229930195729 fatty acid Natural products 0.000 description 1
• 239000010685 fatty oil Substances 0.000 description 1
• 229950003499 fibrin Drugs 0.000 description 1
• 229940012952 fibrinogen Drugs 0.000 description 1
• 210000000968 fibrocartilage Anatomy 0.000 description 1
• 102000034240 fibrous proteins Human genes 0.000 description 1
• 108091005899 fibrous proteins Proteins 0.000 description 1
• 238000001914 filtration Methods 0.000 description 1
• GNBHRKFJIUUOQI-UHFFFAOYSA-N fluorescein Chemical compound O1C(=O)C2=CC=CC=C2C21C1=CC=C(O)C=C1OC1=CC(O)=CC=C21 GNBHRKFJIUUOQI-UHFFFAOYSA-N 0.000 description 1
• 238000002189 fluorescence spectrum Methods 0.000 description 1
• 235000013305 food Nutrition 0.000 description 1
• 239000003205 fragrance Substances 0.000 description 1
• 238000007306 functionalization reaction Methods 0.000 description 1
• ZZUFCTLCJUWOSV-UHFFFAOYSA-N furosemide Chemical compound C1=C(Cl)C(S(=O)(=O)N)=CC(C(O)=O)=C1NCC1=CC=CO1 ZZUFCTLCJUWOSV-UHFFFAOYSA-N 0.000 description 1
• BTCSSZJGUNDROE-UHFFFAOYSA-N gamma-aminobutyric acid Chemical compound NCCCC(O)=O BTCSSZJGUNDROE-UHFFFAOYSA-N 0.000 description 1
• WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 description 1
• 238000001641 gel filtration chromatography Methods 0.000 description 1
• 238000010363 gene targeting Methods 0.000 description 1
• 238000001415 gene therapy Methods 0.000 description 1
• 239000012869 germination medium Substances 0.000 description 1
• 210000004907 gland Anatomy 0.000 description 1
• 239000011521 glass Substances 0.000 description 1
• 239000003365 glass fiber Substances 0.000 description 1
• 239000008103 glucose Substances 0.000 description 1
• 229960003180 glutathione Drugs 0.000 description 1
• 125000005456 glyceride group Chemical group 0.000 description 1
• 235000011187 glycerol Nutrition 0.000 description 1
• 229940125672 glycoprotein IIb/IIIa inhibitor Drugs 0.000 description 1
• 125000003630 glycyl group Chemical group [H]N([H])C([H])([H])C(*)=O 0.000 description 1
• 235000002532 grape seed extract Nutrition 0.000 description 1
• 238000000227 grinding Methods 0.000 description 1
• 239000003102 growth factor Substances 0.000 description 1
• 210000005003 heart tissue Anatomy 0.000 description 1
• 210000003709 heart valve Anatomy 0.000 description 1
• 230000002949 hemolytic effect Effects 0.000 description 1
• RRAMGCGOFNQTLD-UHFFFAOYSA-N hexamethylene diisocyanate Chemical compound O=C=NCCCCCCN=C=O RRAMGCGOFNQTLD-UHFFFAOYSA-N 0.000 description 1
• 229920006253 high performance fiber Polymers 0.000 description 1
• 238000004128 high performance liquid chromatography Methods 0.000 description 1
• HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 description 1
• KJZYNXUDTRRSPN-UHFFFAOYSA-N holmium atom Chemical compound [Ho] KJZYNXUDTRRSPN-UHFFFAOYSA-N 0.000 description 1
• 239000012456 homogeneous solution Substances 0.000 description 1
• 230000009215 host defense mechanism Effects 0.000 description 1
• 239000003906 humectant Substances 0.000 description 1
• 210000003035 hyaline cartilage Anatomy 0.000 description 1
• 208000003906 hydrocephalus Diseases 0.000 description 1
• 230000007062 hydrolysis Effects 0.000 description 1
• 238000006460 hydrolysis reaction Methods 0.000 description 1
• 238000004191 hydrophobic interaction chromatography Methods 0.000 description 1
• QJHBJHUKURJDLG-UHFFFAOYSA-N hydroxy-L-lysine Natural products NCCCCC(NO)C(O)=O QJHBJHUKURJDLG-UHFFFAOYSA-N 0.000 description 1
• TUJKJAMUKRIRHC-UHFFFAOYSA-N hydroxyl Chemical compound [OH] TUJKJAMUKRIRHC-UHFFFAOYSA-N 0.000 description 1
• 229910052588 hydroxylapatite Inorganic materials 0.000 description 1
• 229960002591 hydroxyproline Drugs 0.000 description 1
• 210000001822 immobilized cell Anatomy 0.000 description 1
• 238000003018 immunoassay Methods 0.000 description 1
• 239000003018 immunosuppressive agent Substances 0.000 description 1
• 229940124589 immunosuppressive drug Drugs 0.000 description 1
• 230000001771 impaired effect Effects 0.000 description 1
• 229940097275 indigo Drugs 0.000 description 1
• COHYTHOBJLSHDF-UHFFFAOYSA-N indigo powder Natural products N1C2=CC=CC=C2C(=O)C1=C1C(=O)C2=CC=CC=C2N1 COHYTHOBJLSHDF-UHFFFAOYSA-N 0.000 description 1
• 230000002757 inflammatory effect Effects 0.000 description 1
• 230000004054 inflammatory process Effects 0.000 description 1
• 230000028709 inflammatory response Effects 0.000 description 1
• 239000004615 ingredient Substances 0.000 description 1
• 208000014674 injury Diseases 0.000 description 1
• 229910052500 inorganic mineral Inorganic materials 0.000 description 1
• 102000006495 integrins Human genes 0.000 description 1
• 108010044426 integrins Proteins 0.000 description 1
• 229960001388 interferon-beta Drugs 0.000 description 1
• 230000000968 intestinal effect Effects 0.000 description 1
• 210000000936 intestine Anatomy 0.000 description 1
• 239000007925 intracardiac injection Substances 0.000 description 1
• 230000003834 intracellular effect Effects 0.000 description 1
• 238000007918 intramuscular administration Methods 0.000 description 1
• 239000007928 intraperitoneal injection Substances 0.000 description 1
• 238000010253 intravenous injection Methods 0.000 description 1
• 238000007914 intraventricular administration Methods 0.000 description 1
• 238000004255 ion exchange chromatography Methods 0.000 description 1
• 230000001678 irradiating effect Effects 0.000 description 1
• 230000007794 irritation Effects 0.000 description 1
• RGXCTRIQQODGIZ-UHFFFAOYSA-O isodesmosine Chemical compound OC(=O)C(N)CCCC[N+]1=CC(CCC(N)C(O)=O)=CC(CCC(N)C(O)=O)=C1CCCC(N)C(O)=O RGXCTRIQQODGIZ-UHFFFAOYSA-O 0.000 description 1
• AGPKZVBTJJNPAG-UHFFFAOYSA-N isoleucine Natural products CCC(C)C(N)C(O)=O AGPKZVBTJJNPAG-UHFFFAOYSA-N 0.000 description 1
• 229960000310 isoleucine Drugs 0.000 description 1
• FZWBNHMXJMCXLU-BLAUPYHCSA-N isomaltotriose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@@H](OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C=O)O1 FZWBNHMXJMCXLU-BLAUPYHCSA-N 0.000 description 1
• 230000009191 jumping Effects 0.000 description 1
• 210000003734 kidney Anatomy 0.000 description 1
• 108010021336 lanreotide Proteins 0.000 description 1
• 229960002437 lanreotide Drugs 0.000 description 1
• 235000021374 legumes Nutrition 0.000 description 1
• 238000012698 light-induced step-growth polymerization Methods 0.000 description 1
• 229920005610 lignin Polymers 0.000 description 1
• 150000002632 lipids Chemical class 0.000 description 1
• 239000002502 liposome Substances 0.000 description 1
• 229940057995 liquid paraffin Drugs 0.000 description 1
• 244000144972 livestock Species 0.000 description 1
• 229940127215 low-molecular weight heparin Drugs 0.000 description 1
• 210000003141 lower extremity Anatomy 0.000 description 1
• 239000007937 lozenge Substances 0.000 description 1
• 239000012139 lysis buffer Substances 0.000 description 1
• 230000014759 maintenance of location Effects 0.000 description 1
• 210000001161 mammalian embryo Anatomy 0.000 description 1
• 108010047374 matriptase 2 Proteins 0.000 description 1
• 238000005259 measurement Methods 0.000 description 1
• 108010000525 member 1 small inducible cytokine subfamily E Proteins 0.000 description 1
• 150000002739 metals Chemical class 0.000 description 1
• 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
• 244000005700 microbiome Species 0.000 description 1
• 210000001724 microfibril Anatomy 0.000 description 1
• 238000003801 milling Methods 0.000 description 1
• 239000011707 mineral Substances 0.000 description 1
• 239000002480 mineral oil Substances 0.000 description 1
• 239000011259 mixed solution Substances 0.000 description 1
• 239000003607 modifier Substances 0.000 description 1
• 210000003205 muscle Anatomy 0.000 description 1
• 230000007886 mutagenicity Effects 0.000 description 1
• 231100000299 mutagenicity Toxicity 0.000 description 1
• 230000035772 mutation Effects 0.000 description 1
• 229920005615 natural polymer Polymers 0.000 description 1
• 229930014626 natural product Natural products 0.000 description 1
• 239000006199 nebulizer Substances 0.000 description 1
• 230000001537 neural effect Effects 0.000 description 1
• 210000002241 neurite Anatomy 0.000 description 1
• 229910052759 nickel Inorganic materials 0.000 description 1
• 238000007899 nucleic acid hybridization Methods 0.000 description 1
• 210000004940 nucleus Anatomy 0.000 description 1
• 235000015097 nutrients Nutrition 0.000 description 1
• 239000002674 ointment Substances 0.000 description 1
• JRZJOMJEPLMPRA-UHFFFAOYSA-N olefin Natural products CCCCCCCC=C JRZJOMJEPLMPRA-UHFFFAOYSA-N 0.000 description 1
• 238000002515 oligonucleotide synthesis Methods 0.000 description 1
• 239000003960 organic solvent Substances 0.000 description 1
• 229960003104 ornithine Drugs 0.000 description 1
• 230000000399 orthopedic effect Effects 0.000 description 1
• 230000002018 overexpression Effects 0.000 description 1
• 239000007800 oxidant agent Substances 0.000 description 1
• 230000036542 oxidative stress Effects 0.000 description 1
• 229960001592 paclitaxel Drugs 0.000 description 1
• 210000004923 pancreatic tissue Anatomy 0.000 description 1
• 239000012188 paraffin wax Substances 0.000 description 1
• 244000052769 pathogen Species 0.000 description 1
• 230000001717 pathogenic effect Effects 0.000 description 1
• XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 description 1
• 229940111202 pepsin Drugs 0.000 description 1
• 239000000137 peptide hydrolase inhibitor Substances 0.000 description 1
• 239000002304 perfume Substances 0.000 description 1
• KHIWWQKSHDUIBK-UHFFFAOYSA-M periodate Chemical compound [O-]I(=O)(=O)=O KHIWWQKSHDUIBK-UHFFFAOYSA-M 0.000 description 1
• 230000002093 peripheral effect Effects 0.000 description 1
• 210000001322 periplasm Anatomy 0.000 description 1
• 239000008196 pharmacological composition Substances 0.000 description 1
• 210000003800 pharynx Anatomy 0.000 description 1
• COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 description 1
• NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
• 239000010452 phosphate Substances 0.000 description 1
• 230000008288 physiological mechanism Effects 0.000 description 1
• 239000002504 physiological saline solution Substances 0.000 description 1
• 239000000049 pigment Substances 0.000 description 1
• 239000001739 pinus spp. Substances 0.000 description 1
• 230000036470 plasma concentration Effects 0.000 description 1
• 229920003023 plastic Polymers 0.000 description 1
• 239000004033 plastic Substances 0.000 description 1
• 239000004014 plasticizer Substances 0.000 description 1
• 229920001308 poly(aminoacid) Polymers 0.000 description 1
• 229920000435 poly(dimethylsiloxane) Polymers 0.000 description 1
• 229920001200 poly(ethylene-vinyl acetate) Polymers 0.000 description 1
• 239000005014 poly(hydroxyalkanoate) Substances 0.000 description 1
• 229920002627 poly(phosphazenes) Polymers 0.000 description 1
• 238000002264 polyacrylamide gel electrophoresis Methods 0.000 description 1
• 229920000058 polyacrylate Polymers 0.000 description 1
• 239000004584 polyacrylic acid Substances 0.000 description 1
• 230000008488 polyadenylation Effects 0.000 description 1
• 108010054442 polyalanine Proteins 0.000 description 1
• 229920002647 polyamide Polymers 0.000 description 1
• 229920000767 polyaniline Polymers 0.000 description 1
• 239000004632 polycaprolactone Substances 0.000 description 1
• 229920000515 polycarbonate Polymers 0.000 description 1
• 239000004417 polycarbonate Substances 0.000 description 1
• 229920002721 polycyanoacrylate Polymers 0.000 description 1
• 229920000570 polyether Polymers 0.000 description 1
• 229920000573 polyethylene Polymers 0.000 description 1
• 239000004633 polyglycolic acid Substances 0.000 description 1
• 229920000903 polyhydroxyalkanoate Polymers 0.000 description 1
• 229920000656 polylysine Polymers 0.000 description 1
• 238000003752 polymerase chain reaction Methods 0.000 description 1
• 230000037048 polymerization activity Effects 0.000 description 1
• 229920000193 polymethacrylate Polymers 0.000 description 1
• 229920006324 polyoxymethylene Polymers 0.000 description 1
• 229920001299 polypropylene fumarate Polymers 0.000 description 1
• 229920000128 polypyrrole Polymers 0.000 description 1
• 102000023848 polysaccharide binding proteins Human genes 0.000 description 1
• 108091008395 polysaccharide binding proteins Proteins 0.000 description 1
• 229920000123 polythiophene Polymers 0.000 description 1
• 230000002980 postoperative effect Effects 0.000 description 1
• OXCMYAYHXIHQOA-UHFFFAOYSA-N potassium;[2-butyl-5-chloro-3-[[4-[2-(1,2,4-triaza-3-azanidacyclopenta-1,4-dien-5-yl)phenyl]phenyl]methyl]imidazol-4-yl]methanol Chemical compound [K+].CCCCC1=NC(Cl)=C(CO)N1CC1=CC=C(C=2C(=CC=CC=2)C2=N[N-]N=N2)C=C1 OXCMYAYHXIHQOA-UHFFFAOYSA-N 0.000 description 1
• 239000002243 precursor Substances 0.000 description 1
• 239000000955 prescription drug Substances 0.000 description 1
• 239000003755 preservative agent Substances 0.000 description 1
• 238000012545 processing Methods 0.000 description 1
• 210000001236 prokaryotic cell Anatomy 0.000 description 1
• 239000003380 propellant Substances 0.000 description 1
• 238000000751 protein extraction Methods 0.000 description 1
• 230000012846 protein folding Effects 0.000 description 1
• 230000006920 protein precipitation Effects 0.000 description 1
• 230000030788 protein refolding Effects 0.000 description 1
• 210000001938 protoplast Anatomy 0.000 description 1
• 230000002685 pulmonary effect Effects 0.000 description 1
• 230000000541 pulsatile effect Effects 0.000 description 1
• 239000012521 purified sample Substances 0.000 description 1
• 230000001698 pyrogenic effect Effects 0.000 description 1
• 239000011535 reaction buffer Substances 0.000 description 1
• 238000011084 recovery Methods 0.000 description 1
• 210000000664 rectum Anatomy 0.000 description 1
• 230000002829 reductive effect Effects 0.000 description 1
• 230000022532 regulation of transcription, DNA-dependent Effects 0.000 description 1
• 238000007634 remodeling Methods 0.000 description 1
• 230000003362 replicative effect Effects 0.000 description 1
• 230000004043 responsiveness Effects 0.000 description 1
• 108091008146 restriction endonucleases Proteins 0.000 description 1
• 230000000717 retained effect Effects 0.000 description 1
• 108010051412 reteplase Proteins 0.000 description 1
• 229960002917 reteplase Drugs 0.000 description 1
• 238000004366 reverse phase liquid chromatography Methods 0.000 description 1
• 108010038196 saccharide-binding proteins Proteins 0.000 description 1
• 210000003296 saliva Anatomy 0.000 description 1
• 150000003839 salts Chemical class 0.000 description 1
• 229920006395 saturated elastomer Polymers 0.000 description 1
• 230000003248 secreting effect Effects 0.000 description 1
• 238000010187 selection method Methods 0.000 description 1
• 230000010153 self-pollination Effects 0.000 description 1
• 229920006126 semicrystalline polymer Polymers 0.000 description 1
• 239000008159 sesame oil Substances 0.000 description 1
• 235000011803 sesame oil Nutrition 0.000 description 1
• 239000002453 shampoo Substances 0.000 description 1
• 238000007493 shaping process Methods 0.000 description 1
• 230000035939 shock Effects 0.000 description 1
• 238000004904 shortening Methods 0.000 description 1
• 239000013605 shuttle vector Substances 0.000 description 1
• HBMJWWWQQXIZIP-UHFFFAOYSA-N silicon carbide Chemical compound [Si+]#[C-] HBMJWWWQQXIZIP-UHFFFAOYSA-N 0.000 description 1
• 229910010271 silicon carbide Inorganic materials 0.000 description 1
• 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 1
• 229920001027 sodium carboxymethylcellulose Polymers 0.000 description 1
• SUKJFIGYRHOWBL-UHFFFAOYSA-N sodium hypochlorite Chemical compound [Na+].Cl[O-] SUKJFIGYRHOWBL-UHFFFAOYSA-N 0.000 description 1
• 239000002904 solvent Substances 0.000 description 1
• 230000000392 somatic effect Effects 0.000 description 1
• 239000000600 sorbitol Substances 0.000 description 1
• 125000006850 spacer group Chemical group 0.000 description 1
• 230000009870 specific binding Effects 0.000 description 1
• 210000005070 sphincter Anatomy 0.000 description 1
• 238000009987 spinning Methods 0.000 description 1
• 239000007921 spray Substances 0.000 description 1
• 235000020354 squash Nutrition 0.000 description 1
• 230000000087 stabilizing effect Effects 0.000 description 1
• 238000003153 stable transfection Methods 0.000 description 1
• 238000010186 staining Methods 0.000 description 1
• 239000010959 steel Substances 0.000 description 1
• 230000001954 sterilising effect Effects 0.000 description 1
• 238000004659 sterilization and disinfection Methods 0.000 description 1
• 230000000638 stimulation Effects 0.000 description 1
• 238000003756 stirring Methods 0.000 description 1
• 239000010902 straw Substances 0.000 description 1
• 238000007920 subcutaneous administration Methods 0.000 description 1
• TYFQFVWCELRYAO-UHFFFAOYSA-L suberate(2-) Chemical compound [O-]C(=O)CCCCCCC([O-])=O TYFQFVWCELRYAO-UHFFFAOYSA-L 0.000 description 1
• 239000000758 substrate Substances 0.000 description 1
• 230000036561 sun exposure Effects 0.000 description 1
• 239000000829 suppository Substances 0.000 description 1
• 239000002511 suppository base Substances 0.000 description 1
• 230000004083 survival effect Effects 0.000 description 1
• 239000000375 suspending agent Substances 0.000 description 1
• 238000004114 suspension culture Methods 0.000 description 1
• 208000024891 symptom Diseases 0.000 description 1
• 229920002994 synthetic fiber Polymers 0.000 description 1
• 229920001059 synthetic polymer Polymers 0.000 description 1
• 229960001967 tacrolimus Drugs 0.000 description 1
• QJJXYPPXXYFBGM-SHYZHZOCSA-N tacrolimus Natural products CO[C@H]1C[C@H](CC[C@@H]1O)C=C(C)[C@H]2OC(=O)[C@H]3CCCCN3C(=O)C(=O)[C@@]4(O)O[C@@H]([C@H](C[C@H]4C)OC)[C@@H](C[C@H](C)CC(=C[C@@H](CC=C)C(=O)C[C@H](O)[C@H]2C)C)OC QJJXYPPXXYFBGM-SHYZHZOCSA-N 0.000 description 1
• 230000008685 targeting Effects 0.000 description 1
• RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 description 1
• 210000001738 temporomandibular joint Anatomy 0.000 description 1
• 210000002435 tendon Anatomy 0.000 description 1
• 229940124597 therapeutic agent Drugs 0.000 description 1
• 238000002560 therapeutic procedure Methods 0.000 description 1
• 229960000187 tissue plasminogen activator Drugs 0.000 description 1
• 230000017423 tissue regeneration Effects 0.000 description 1
• 239000003860 topical agent Substances 0.000 description 1
• 229960005342 tranilast Drugs 0.000 description 1
• NZHGWWWHIYHZNX-CSKARUKUSA-N tranilast Chemical compound C1=C(OC)C(OC)=CC=C1\C=C\C(=O)NC1=CC=CC=C1C(O)=O NZHGWWWHIYHZNX-CSKARUKUSA-N 0.000 description 1
• FGMPLJWBKKVCDB-UHFFFAOYSA-N trans-L-hydroxy-proline Natural products ON1CCCC1C(O)=O FGMPLJWBKKVCDB-UHFFFAOYSA-N 0.000 description 1
• 230000005026 transcription initiation Effects 0.000 description 1
• 238000003146 transient transfection Methods 0.000 description 1
• 230000014621 translational initiation Effects 0.000 description 1
• 238000004627 transmission electron microscopy Methods 0.000 description 1
• 229960000363 trapidil Drugs 0.000 description 1
• 150000003626 triacylglycerols Chemical class 0.000 description 1
• QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
• CYRMSUTZVYGINF-UHFFFAOYSA-N trichlorofluoromethane Chemical compound FC(Cl)(Cl)Cl CYRMSUTZVYGINF-UHFFFAOYSA-N 0.000 description 1
• 229940029284 trichlorofluoromethane Drugs 0.000 description 1
• 239000013638 trimer Substances 0.000 description 1
• GPRLSGONYQIRFK-MNYXATJNSA-N triton Chemical compound [3H+] GPRLSGONYQIRFK-MNYXATJNSA-N 0.000 description 1
• 239000012588 trypsin Substances 0.000 description 1
• WFKWXMTUELFFGS-UHFFFAOYSA-N tungsten Chemical compound [W] WFKWXMTUELFFGS-UHFFFAOYSA-N 0.000 description 1
• 229910052721 tungsten Inorganic materials 0.000 description 1
• 239000010937 tungsten Substances 0.000 description 1
• 238000009281 ultraviolet germicidal irradiation Methods 0.000 description 1
• 241000701447 unidentified baculovirus Species 0.000 description 1
• 241001515965 unidentified phage Species 0.000 description 1
• VBEQCZHXXJYVRD-GACYYNSASA-N uroanthelone Chemical compound C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CS)C(=O)N[C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)C(C)C)[C@@H](C)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CCSC)NC(=O)[C@H](CS)NC(=O)[C@@H](NC(=O)CNC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CS)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CS)NC(=O)CNC(=O)[C@H]1N(CCC1)C(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(N)=O)C(C)C)[C@@H](C)CC)C1=CC=C(O)C=C1 VBEQCZHXXJYVRD-GACYYNSASA-N 0.000 description 1
• 230000002792 vascular Effects 0.000 description 1
• 210000003462 vein Anatomy 0.000 description 1
• 210000005048 vimentin Anatomy 0.000 description 1
• 210000002845 virion Anatomy 0.000 description 1
• 239000011719 vitamin A Substances 0.000 description 1
• 235000019155 vitamin A Nutrition 0.000 description 1
• 239000011718 vitamin C Substances 0.000 description 1
• 235000019154 vitamin C Nutrition 0.000 description 1
• 239000011709 vitamin E Substances 0.000 description 1
• 235000019165 vitamin E Nutrition 0.000 description 1
• 229940046009 vitamin E Drugs 0.000 description 1
• 229940045997 vitamin a Drugs 0.000 description 1
• 238000005406 washing Methods 0.000 description 1
• 210000002268 wool Anatomy 0.000 description 1
• 210000000707 wrist Anatomy 0.000 description 1