JP2011503012A5 - - Google Patents
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- JP2011503012A5 JP2011503012A5 JP2010532342A JP2010532342A JP2011503012A5 JP 2011503012 A5 JP2011503012 A5 JP 2011503012A5 JP 2010532342 A JP2010532342 A JP 2010532342A JP 2010532342 A JP2010532342 A JP 2010532342A JP 2011503012 A5 JP2011503012 A5 JP 2011503012A5
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- Prior art keywords
- histone
- inhibitor
- subject
- peptide
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- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 108010033040 Histones Proteins 0.000 claims description 72
- 239000003112 inhibitor Substances 0.000 claims description 69
- 238000000034 method Methods 0.000 claims description 54
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 48
- 230000003013 cytotoxicity Effects 0.000 claims description 34
- 231100000135 cytotoxicity Toxicity 0.000 claims description 34
- 239000012634 fragment Substances 0.000 claims description 24
- 230000002583 anti-histone Effects 0.000 claims description 20
- 201000000596 systemic lupus erythematosus Diseases 0.000 claims description 17
- 239000008194 pharmaceutical composition Substances 0.000 claims description 10
- 230000001988 toxicity Effects 0.000 claims description 7
- 231100000419 toxicity Toxicity 0.000 claims description 7
- 241000283707 Capra Species 0.000 claims description 6
- 241000282693 Cercopithecidae Species 0.000 claims description 6
- 241000282326 Felis catus Species 0.000 claims description 6
- 241000283973 Oryctolagus cuniculus Species 0.000 claims description 6
- 241001494479 Pecora Species 0.000 claims description 6
- 208000014674 injury Diseases 0.000 claims description 6
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 6
- 230000008733 trauma Effects 0.000 claims description 6
- 231100000433 cytotoxic Toxicity 0.000 claims description 5
- 230000001472 cytotoxic effect Effects 0.000 claims description 5
- 208000024172 Cardiovascular disease Diseases 0.000 claims description 4
- 108090000695 Cytokines Proteins 0.000 claims description 4
- 102000004127 Cytokines Human genes 0.000 claims description 4
- 102000001398 Granzyme Human genes 0.000 claims description 4
- 108060005986 Granzyme Proteins 0.000 claims description 4
- 102000006947 Histones Human genes 0.000 claims description 4
- 101800004937 Protein C Proteins 0.000 claims description 4
- 101800001700 Saposin-D Proteins 0.000 claims description 4
- 102400000827 Saposin-D Human genes 0.000 claims description 4
- 230000000770 proinflammatory effect Effects 0.000 claims description 4
- 229960000856 protein c Drugs 0.000 claims description 4
- 239000002260 anti-inflammatory agent Substances 0.000 claims description 3
- 229940121363 anti-inflammatory agent Drugs 0.000 claims description 3
- 206010001052 Acute respiratory distress syndrome Diseases 0.000 claims description 2
- 201000001320 Atherosclerosis Diseases 0.000 claims description 2
- 208000023275 Autoimmune disease Diseases 0.000 claims description 2
- 241000193738 Bacillus anthracis Species 0.000 claims description 2
- 206010061818 Disease progression Diseases 0.000 claims description 2
- 238000002965 ELISA Methods 0.000 claims description 2
- 108010023321 Factor VII Proteins 0.000 claims description 2
- 108010088842 Fibrinolysin Proteins 0.000 claims description 2
- 206010058872 Fungal sepsis Diseases 0.000 claims description 2
- 208000032843 Hemorrhage Diseases 0.000 claims description 2
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 claims description 2
- 108090001005 Interleukin-6 Proteins 0.000 claims description 2
- 108090001007 Interleukin-8 Proteins 0.000 claims description 2
- 206010030113 Oedema Diseases 0.000 claims description 2
- 206010033645 Pancreatitis Diseases 0.000 claims description 2
- 206010033647 Pancreatitis acute Diseases 0.000 claims description 2
- 108091005804 Peptidases Proteins 0.000 claims description 2
- 239000004365 Protease Substances 0.000 claims description 2
- 206010063837 Reperfusion injury Diseases 0.000 claims description 2
- 208000013616 Respiratory Distress Syndrome Diseases 0.000 claims description 2
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 claims description 2
- 201000003229 acute pancreatitis Diseases 0.000 claims description 2
- 201000000028 adult respiratory distress syndrome Diseases 0.000 claims description 2
- 201000005008 bacterial sepsis Diseases 0.000 claims description 2
- 230000001684 chronic effect Effects 0.000 claims description 2
- 230000005796 circulatory shock Effects 0.000 claims description 2
- 230000016396 cytokine production Effects 0.000 claims description 2
- 201000010099 disease Diseases 0.000 claims description 2
- 230000005750 disease progression Effects 0.000 claims description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 2
- 210000002889 endothelial cell Anatomy 0.000 claims description 2
- 230000003511 endothelial effect Effects 0.000 claims description 2
- 229960002897 heparin Drugs 0.000 claims description 2
- 229920000669 heparin Polymers 0.000 claims description 2
- 208000012947 ischemia reperfusion injury Diseases 0.000 claims description 2
- 230000035699 permeability Effects 0.000 claims description 2
- 229940012957 plasmin Drugs 0.000 claims description 2
- 238000004393 prognosis Methods 0.000 claims description 2
- 238000001959 radiotherapy Methods 0.000 claims description 2
- 210000002966 serum Anatomy 0.000 claims description 2
- 238000001356 surgical procedure Methods 0.000 claims description 2
- 230000001225 therapeutic effect Effects 0.000 claims description 2
- 238000002560 therapeutic procedure Methods 0.000 claims description 2
- 230000000451 tissue damage Effects 0.000 claims description 2
- 231100000827 tissue damage Toxicity 0.000 claims description 2
- 230000005747 tumor angiogenesis Effects 0.000 claims description 2
- 230000002792 vascular Effects 0.000 claims description 2
- 238000001262 western blot Methods 0.000 claims description 2
- 239000003814 drug Substances 0.000 claims 4
- 238000004519 manufacturing process Methods 0.000 claims 4
- 230000003213 activating effect Effects 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 description 3
- 206010025135 lupus erythematosus Diseases 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US98588607P | 2007-11-06 | 2007-11-06 | |
| PCT/US2008/082632 WO2009061918A1 (en) | 2007-11-06 | 2008-11-06 | Extracellular histones as biomarkers for prognosis and molecular targets for therapy |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2011503012A JP2011503012A (ja) | 2011-01-27 |
| JP2011503012A5 true JP2011503012A5 (enExample) | 2012-11-08 |
Family
ID=40270490
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010532342A Pending JP2011503012A (ja) | 2007-11-06 | 2008-11-06 | 予後に関するバイオマーカーおよび治療の分子標的としての細胞外ヒストン |
Country Status (6)
| Country | Link |
|---|---|
| US (5) | US8716218B2 (enExample) |
| EP (1) | EP2209485B1 (enExample) |
| JP (1) | JP2011503012A (enExample) |
| AU (1) | AU2008323947B2 (enExample) |
| CA (1) | CA2704974C (enExample) |
| WO (1) | WO2009061918A1 (enExample) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2704974C (en) | 2007-11-06 | 2019-06-04 | Oklahoma Medical Research Foundation | Extracellular histones as biomarkers for prognosis and molecular targets for therapy |
| WO2009062948A1 (en) * | 2007-11-16 | 2009-05-22 | Pronota N.V. | Biomarkers and methods for diagnosing, predicting and/or prognosing sepsis and uses thereof |
| WO2012023614A1 (ja) | 2010-08-20 | 2012-02-23 | 学校法人 城西大学 | 免疫抑制活性を有するモノクローナル抗体またはその抗原結合断片 |
| WO2012067152A1 (ja) * | 2010-11-16 | 2012-05-24 | 三菱化学株式会社 | Endothelial Protein C Receptor蛋白質による脳梗塞の検査方法 |
| SG190438A1 (en) * | 2010-12-01 | 2013-07-31 | Univ Australian | Histone inhibition |
| TWI442934B (zh) * | 2011-03-11 | 2014-07-01 | Univ Taipei Medical | 組蛋白h4抗體的用途 |
| JP2015117181A (ja) * | 2012-02-22 | 2015-06-25 | 学校法人 城西大学 | 敗血症治療剤 |
| EP2931314A4 (en) | 2013-02-15 | 2016-12-07 | Immunomedics Inc | CHIMERIC AND HUMANIZED ANTI-HISTON ANTIBODIES |
| JPWO2013125687A1 (ja) * | 2013-02-22 | 2015-07-30 | 学校法人 城西大学 | 炎症疾患治療剤 |
| FR3007411B1 (fr) * | 2013-06-21 | 2015-07-03 | Agronomique Inst Nat Rech | Anticorps monocatenaire a chaine lourde de camelide dirige contre la chromatine et utilisations |
| US9580495B2 (en) | 2014-06-24 | 2017-02-28 | Immunomedics, Inc. | Anti-histone therapy for vascular necrosis in severe glomerulonephritis |
| US10351621B2 (en) | 2014-06-24 | 2019-07-16 | Immunomedics, Inc. | Anti-histone therapy in acute kidney injury |
| EP3164123B1 (en) * | 2014-07-02 | 2020-05-20 | InFlectis BioScience | Novel therapeutic uses of benzylideneguanidine derivatives for the treatment of proteopathies |
| WO2016106387A2 (en) | 2014-12-22 | 2016-06-30 | University Of Iowa Research Foundation | Nucleic acid aptamers to treat histone-induced disease states |
| WO2016128383A1 (en) | 2015-02-10 | 2016-08-18 | B.R.A.H.M.S Gmbh | Free histone proteins as biomarkers |
| CN106611094B (zh) * | 2015-10-15 | 2021-08-06 | 北京寻因生物科技有限公司 | 基于肠道微生物菌群预测及干预化疗药物毒副反应的系统 |
| JP6738652B2 (ja) * | 2016-05-26 | 2020-08-12 | シスメックス株式会社 | 試料分析方法、試料分析装置および試薬 |
| CN109564226A (zh) * | 2016-08-09 | 2019-04-02 | B.R.A.H.M.S 有限公司 | 作为指示器官功能障碍的标志物的组蛋白和/或proADM |
| EP3497451B1 (en) | 2016-08-09 | 2025-06-18 | B.R.A.H.M.S GmbH | Histones and/or proadm as markers indicating an adverse event |
| CN106397575A (zh) * | 2016-10-20 | 2017-02-15 | 上海懿贝瑞生物医药科技有限公司 | 一种具有胞外组蛋白毒性抑制作用的多肽制备方法及用途 |
| ES2840056T3 (es) | 2016-11-04 | 2021-07-06 | Centro De Investig Biomedica En Red Ciber Isciii | Métodos basados en espectrometría de masas para la detección de histonas circulantes H3 y H2B en plasma a partir de pacientes con septicemia o choque séptico (SS) |
| EP3577465B1 (en) | 2017-02-02 | 2023-03-29 | B.R.A.H.M.S GmbH | Proadm as marker indicating an adverse event |
| JP2020073459A (ja) * | 2017-03-06 | 2020-05-14 | 学校法人順天堂 | ヒストンによる細胞傷害を抑制するための薬剤 |
| ES2913665T3 (es) | 2017-09-18 | 2022-06-03 | Santersus Ag | Método y dispositivo para la purificación de sangre a partir de ADN celular libre en circulación |
| GB201804833D0 (en) * | 2018-03-26 | 2018-05-09 | Univ Liverpool | Pro-coagulant histones |
| CN110101838B (zh) * | 2019-04-29 | 2022-07-01 | 陕西师范大学 | 一种提高组蛋白抗大肠杆菌性能的方法 |
| CN111202839A (zh) * | 2020-02-21 | 2020-05-29 | 佛山科学技术学院 | 一种组蛋白h4在抑制禽流感病毒中的应用 |
| WO2021198535A1 (en) * | 2020-04-03 | 2021-10-07 | Medsenic | Use of an arsenic compound for treating a short or long cytokine storm in various autoimmune/inflammatory diseases in humans or animals |
| CN112679579B (zh) * | 2020-12-29 | 2022-02-01 | 潍坊医学院 | 一种分离自华蟾素注射液的镇痛肽ci5及其应用 |
| US12053567B2 (en) | 2021-12-27 | 2024-08-06 | Santersus Ag | Method and device for removal of circulating cell free DNA |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000064466A1 (en) * | 1999-04-28 | 2000-11-02 | Northwestern University | Localization of major peptide autoepitopes for nucleosome specific t cells of systemic lupus erythematosus |
| US7238656B2 (en) * | 2001-08-29 | 2007-07-03 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Protective factors against inflammation, burns and noxious stimuli |
| US7528227B2 (en) * | 2004-03-23 | 2009-05-05 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Histone H2A peptide derivatives and uses thereof |
| TW200407335A (en) * | 2002-07-22 | 2004-05-16 | Chugai Pharmaceutical Co Ltd | Non-neutralizing antibody to inhibit the inactivation of activated protein C |
| JP4834826B2 (ja) | 2003-07-22 | 2011-12-14 | 独立行政法人産業技術総合研究所 | ヒストンｈ３及びｈ４リンカー領域を認識するモノクローナル抗体及びその産生ハイブリドーマ |
| AU2005250499B2 (en) * | 2004-06-03 | 2011-12-08 | Novimmune S.A. | Anti-CD3 antibodies and methods of use thereof |
| JP2007246473A (ja) | 2006-03-17 | 2007-09-27 | Chemo Sero Therapeut Res Inst | 臓器障害抑制剤 |
| EP2011490A1 (en) | 2007-07-05 | 2009-01-07 | Sanofi-Aventis | Beta adrenergic receptor ligand derivatives for modulating apoptosis |
| CA2704974C (en) * | 2007-11-06 | 2019-06-04 | Oklahoma Medical Research Foundation | Extracellular histones as biomarkers for prognosis and molecular targets for therapy |
-
2008
- 2008-11-06 CA CA2704974A patent/CA2704974C/en active Active
- 2008-11-06 WO PCT/US2008/082632 patent/WO2009061918A1/en not_active Ceased
- 2008-11-06 AU AU2008323947A patent/AU2008323947B2/en active Active
- 2008-11-06 US US12/266,336 patent/US8716218B2/en active Active
- 2008-11-06 JP JP2010532342A patent/JP2011503012A/ja active Pending
- 2008-11-06 EP EP08847874.8A patent/EP2209485B1/en active Active
-
2014
- 2014-05-06 US US14/270,470 patent/US10238711B2/en active Active
-
2015
- 2015-06-09 US US14/734,238 patent/US10350261B2/en active Active
-
2017
- 2017-12-12 US US15/838,639 patent/US20180092961A1/en not_active Abandoned
-
2019
- 2019-01-31 US US16/263,124 patent/US11458187B2/en active Active
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