JP2011502172A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2011502172A5 JP2011502172A5 JP2010532376A JP2010532376A JP2011502172A5 JP 2011502172 A5 JP2011502172 A5 JP 2011502172A5 JP 2010532376 A JP2010532376 A JP 2010532376A JP 2010532376 A JP2010532376 A JP 2010532376A JP 2011502172 A5 JP2011502172 A5 JP 2011502172A5
- Authority
- JP
- Japan
- Prior art keywords
- acetate
- delivery system
- transdermal delivery
- sodium
- pharmacological agent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- 230000037317 transdermal delivery Effects 0.000 claims 17
- 239000000203 mixture Substances 0.000 claims 13
- 239000002831 pharmacologic agent Substances 0.000 claims 8
- 229940088597 hormone Drugs 0.000 claims 7
- 239000005556 hormone Substances 0.000 claims 7
- 150000003431 steroids Chemical class 0.000 claims 7
- 239000002202 Polyethylene glycol Substances 0.000 claims 6
- 229920001223 polyethylene glycol Polymers 0.000 claims 6
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 4
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 claims 4
- MUMGGOZAMZWBJJ-DYKIIFRCSA-N Testostosterone Chemical compound O=C1CC[C@]2(C)[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 MUMGGOZAMZWBJJ-DYKIIFRCSA-N 0.000 claims 4
- JYGXADMDTFJGBT-VWUMJDOOSA-N hydrocortisone Chemical compound O=C1CC[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 JYGXADMDTFJGBT-VWUMJDOOSA-N 0.000 claims 4
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims 3
- FQISKWAFAHGMGT-SGJOWKDISA-M Methylprednisolone sodium succinate Chemical compound [Na+].C([C@@]12C)=CC(=O)C=C1[C@@H](C)C[C@@H]1[C@@H]2[C@@H](O)C[C@]2(C)[C@@](O)(C(=O)COC(=O)CCC([O-])=O)CC[C@H]21 FQISKWAFAHGMGT-SGJOWKDISA-M 0.000 claims 3
- 230000035515 penetration Effects 0.000 claims 3
- 229910052708 sodium Inorganic materials 0.000 claims 3
- 239000011734 sodium Substances 0.000 claims 3
- 239000002904 solvent Substances 0.000 claims 3
- 239000007921 spray Substances 0.000 claims 3
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 claims 2
- VPGRYOFKCNULNK-ACXQXYJUSA-N Deoxycorticosterone acetate Chemical compound C1CC2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H](C(=O)COC(=O)C)[C@@]1(C)CC2 VPGRYOFKCNULNK-ACXQXYJUSA-N 0.000 claims 2
- IMONTRJLAWHYGT-ZCPXKWAGSA-N Norethindrone Acetate Chemical compound C1CC2=CC(=O)CC[C@@H]2[C@@H]2[C@@H]1[C@@H]1CC[C@](C#C)(OC(=O)C)[C@@]1(C)CC2 IMONTRJLAWHYGT-ZCPXKWAGSA-N 0.000 claims 2
- LRJOMUJRLNCICJ-JZYPGELDSA-N Prednisolone acetate Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@@](C(=O)COC(=O)C)(O)[C@@]1(C)C[C@@H]2O LRJOMUJRLNCICJ-JZYPGELDSA-N 0.000 claims 2
- RJKFOVLPORLFTN-LEKSSAKUSA-N Progesterone Chemical compound C1CC2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H](C(=O)C)[C@@]1(C)CC2 RJKFOVLPORLFTN-LEKSSAKUSA-N 0.000 claims 2
- LTXUBHXFNYNXJW-NGOGOHBQSA-N acetic acid (8S,9S,10R,13S,14S,17S)-17-acetyl-16-(hydroxymethyl)-10,13-dimethyl-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one Chemical compound CC(O)=O.C1CC2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC(CO)[C@H](C(=O)C)[C@@]1(C)CC2 LTXUBHXFNYNXJW-NGOGOHBQSA-N 0.000 claims 2
- 239000003098 androgen Substances 0.000 claims 2
- FFIAPLNALYDYQK-UHFFFAOYSA-L barium(2+);[2,3,4-trihydroxy-5-(hydroxymethyl)oxolan-2-yl]methyl phosphate Chemical compound [Ba+2].OCC1OC(O)(COP([O-])([O-])=O)C(O)C1O FFIAPLNALYDYQK-UHFFFAOYSA-L 0.000 claims 2
- 229960002537 betamethasone Drugs 0.000 claims 2
- UREBDLICKHMUKA-DVTGEIKXSA-N betamethasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@H](C)[C@@](C(=O)CO)(O)[C@@]1(C)C[C@@H]2O UREBDLICKHMUKA-DVTGEIKXSA-N 0.000 claims 2
- VQODGRNSFPNSQE-DVTGEIKXSA-N betamethasone phosphate Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@H](C)[C@@](C(=O)COP(O)(O)=O)(O)[C@@]1(C)C[C@@H]2O VQODGRNSFPNSQE-DVTGEIKXSA-N 0.000 claims 2
- 229950006991 betamethasone phosphate Drugs 0.000 claims 2
- -1 desoxymeta Zon Chemical compound 0.000 claims 2
- 239000003623 enhancer Substances 0.000 claims 2
- 229940011871 estrogen Drugs 0.000 claims 2
- 239000000262 estrogen Substances 0.000 claims 2
- 229960000890 hydrocortisone Drugs 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 229960000334 methylprednisolone sodium succinate Drugs 0.000 claims 2
- 229960001652 norethindrone acetate Drugs 0.000 claims 2
- 229960002800 prednisolone acetate Drugs 0.000 claims 2
- JDOZJEUDSLGTLU-VWUMJDOOSA-N prednisolone phosphate Chemical compound O=C1C=C[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)COP(O)(O)=O)[C@@H]4[C@@H]3CCC2=C1 JDOZJEUDSLGTLU-VWUMJDOOSA-N 0.000 claims 2
- 229960002943 prednisolone sodium phosphate Drugs 0.000 claims 2
- 229960003604 testosterone Drugs 0.000 claims 2
- 229960005294 triamcinolone Drugs 0.000 claims 2
- GFNANZIMVAIWHM-OBYCQNJPSA-N triamcinolone Chemical compound O=C1C=C[C@]2(C)[C@@]3(F)[C@@H](O)C[C@](C)([C@@]([C@H](O)C4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 GFNANZIMVAIWHM-OBYCQNJPSA-N 0.000 claims 2
- 229960002117 triamcinolone acetonide Drugs 0.000 claims 2
- YNDXUCZADRHECN-JNQJZLCISA-N triamcinolone acetonide Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@H]3OC(C)(C)O[C@@]3(C(=O)CO)[C@@]1(C)C[C@@H]2O YNDXUCZADRHECN-JNQJZLCISA-N 0.000 claims 2
- DNXHEGUUPJUMQT-UHFFFAOYSA-N (+)-estrone Natural products OC1=CC=C2C3CCC(C)(C(CC4)=O)C4C3CCC2=C1 DNXHEGUUPJUMQT-UHFFFAOYSA-N 0.000 claims 1
- PROQIPRRNZUXQM-UHFFFAOYSA-N (16alpha,17betaOH)-Estra-1,3,5(10)-triene-3,16,17-triol Natural products OC1=CC=C2C3CCC(C)(C(C(O)C4)O)C4C3CCC2=C1 PROQIPRRNZUXQM-UHFFFAOYSA-N 0.000 claims 1
- ZKFNOUUKULVDOB-UHFFFAOYSA-N 1-amino-1-phenylmethyl phosphonic acid Chemical compound OP(=O)(O)C(N)C1=CC=CC=C1 ZKFNOUUKULVDOB-UHFFFAOYSA-N 0.000 claims 1
- FUFLCEKSBBHCMO-UHFFFAOYSA-N 11-dehydrocorticosterone Natural products O=C1CCC2(C)C3C(=O)CC(C)(C(CC4)C(=O)CO)C4C3CCC2=C1 FUFLCEKSBBHCMO-UHFFFAOYSA-N 0.000 claims 1
- VVOIQBFMTVCINR-WWMZEODYSA-N 11-deoxycorticosterone pivalate Chemical compound C1CC2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H](C(=O)COC(=O)C(C)(C)C)[C@@]1(C)CC2 VVOIQBFMTVCINR-WWMZEODYSA-N 0.000 claims 1
- VTHUYJIXSMGYOQ-KOORYGTMSA-N 17-hydroxyprogesterone acetate Chemical compound C1CC2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@@](C(C)=O)(OC(=O)C)[C@@]1(C)CC2 VTHUYJIXSMGYOQ-KOORYGTMSA-N 0.000 claims 1
- BFPYWIDHMRZLRN-UHFFFAOYSA-N 17alpha-ethynyl estradiol Natural products OC1=CC=C2C3CCC(C)(C(CC4)(O)C#C)C4C3CCC2=C1 BFPYWIDHMRZLRN-UHFFFAOYSA-N 0.000 claims 1
- GCKMFJBGXUYNAG-UHFFFAOYSA-N 17alpha-methyltestosterone Natural products C1CC2=CC(=O)CCC2(C)C2C1C1CCC(C)(O)C1(C)CC2 GCKMFJBGXUYNAG-UHFFFAOYSA-N 0.000 claims 1
- DBPWSSGDRRHUNT-CEGNMAFCSA-N 17α-hydroxyprogesterone Chemical compound C1CC2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@@](C(=O)C)(O)[C@@]1(C)CC2 DBPWSSGDRRHUNT-CEGNMAFCSA-N 0.000 claims 1
- VOXZDWNPVJITMN-ZBRFXRBCSA-N 17β-estradiol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 VOXZDWNPVJITMN-ZBRFXRBCSA-N 0.000 claims 1
- QTQGHKVYLQBJLO-UHFFFAOYSA-N 4-methylbenzenesulfonate;(4-methyl-1-oxo-1-phenylmethoxypentan-2-yl)azanium Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1.CC(C)CC(N)C(=O)OCC1=CC=CC=C1 QTQGHKVYLQBJLO-UHFFFAOYSA-N 0.000 claims 1
- QGXBDMJGAMFCBF-HLUDHZFRSA-N 5α-Androsterone Chemical compound C1[C@H](O)CC[C@]2(C)[C@H]3CC[C@](C)(C(CC4)=O)[C@@H]4[C@@H]3CC[C@H]21 QGXBDMJGAMFCBF-HLUDHZFRSA-N 0.000 claims 1
- MEZCUMCMVYZPAH-UHFFFAOYSA-N 6-fluoro-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-2,6,7,8,9,11,12,14,15,16-decahydro-1h-cyclopenta[a]phenanthren-3-one Chemical compound O=C1CCC2(C)C3C(O)CC(C)(C(CC4)(O)C(=O)CO)C4C3CC(F)C2=C1 MEZCUMCMVYZPAH-UHFFFAOYSA-N 0.000 claims 1
- MYYIMZRZXIQBGI-HVIRSNARSA-N 6alpha-Fluoroprednisolone Chemical compound O=C1C=C[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3C[C@H](F)C2=C1 MYYIMZRZXIQBGI-HVIRSNARSA-N 0.000 claims 1
- PQSUYGKTWSAVDQ-ZVIOFETBSA-N Aldosterone Chemical compound C([C@@]1([C@@H](C(=O)CO)CC[C@H]1[C@@H]1CC2)C=O)[C@H](O)[C@@H]1[C@]1(C)C2=CC(=O)CC1 PQSUYGKTWSAVDQ-ZVIOFETBSA-N 0.000 claims 1
- PQSUYGKTWSAVDQ-UHFFFAOYSA-N Aldosterone Natural products C1CC2C3CCC(C(=O)CO)C3(C=O)CC(O)C2C2(C)C1=CC(=O)CC2 PQSUYGKTWSAVDQ-UHFFFAOYSA-N 0.000 claims 1
- UYIFTLBWAOGQBI-BZDYCCQFSA-N Benzhormovarine Chemical compound C([C@@H]1[C@@H](C2=CC=3)CC[C@]4([C@H]1CC[C@@H]4O)C)CC2=CC=3OC(=O)C1=CC=CC=C1 UYIFTLBWAOGQBI-BZDYCCQFSA-N 0.000 claims 1
- 229920006051 Capron® Polymers 0.000 claims 1
- QMBJSIBWORFWQT-DFXBJWIESA-N Chlormadinone acetate Chemical compound C1=C(Cl)C2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@@](C(C)=O)(OC(=O)C)[C@@]1(C)CC2 QMBJSIBWORFWQT-DFXBJWIESA-N 0.000 claims 1
- OMFXVFTZEKFJBZ-UHFFFAOYSA-N Corticosterone Natural products O=C1CCC2(C)C3C(O)CC(C)(C(CC4)C(=O)CO)C4C3CCC2=C1 OMFXVFTZEKFJBZ-UHFFFAOYSA-N 0.000 claims 1
- MFYSYFVPBJMHGN-ZPOLXVRWSA-N Cortisone Chemical compound O=C1CC[C@]2(C)[C@H]3C(=O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 MFYSYFVPBJMHGN-ZPOLXVRWSA-N 0.000 claims 1
- MFYSYFVPBJMHGN-UHFFFAOYSA-N Cortisone Natural products O=C1CCC2(C)C3C(=O)CC(C)(C(CC4)(O)C(=O)CO)C4C3CCC2=C1 MFYSYFVPBJMHGN-UHFFFAOYSA-N 0.000 claims 1
- ITRJWOMZKQRYTA-RFZYENFJSA-N Cortisone acetate Chemical compound C1CC2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@@](C(=O)COC(=O)C)(O)[C@@]1(C)CC2=O ITRJWOMZKQRYTA-RFZYENFJSA-N 0.000 claims 1
- LVHOURKCKUYIGK-RGUJTQARSA-N Dimethisterone Chemical compound C1([C@@H](C)C2)=CC(=O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@](C#CC)(O)[C@@]2(C)CC1 LVHOURKCKUYIGK-RGUJTQARSA-N 0.000 claims 1
- UOACKFBJUYNSLK-XRKIENNPSA-N Estradiol Cypionate Chemical compound O([C@H]1CC[C@H]2[C@H]3[C@@H](C4=CC=C(O)C=C4CC3)CC[C@@]21C)C(=O)CCC1CCCC1 UOACKFBJUYNSLK-XRKIENNPSA-N 0.000 claims 1
- JQIYNMYZKRGDFK-RUFWAXPRSA-N Estradiol dipropionate Chemical compound C1CC2=CC(OC(=O)CC)=CC=C2[C@@H]2[C@@H]1[C@@H]1CC[C@H](OC(=O)CC)[C@@]1(C)CC2 JQIYNMYZKRGDFK-RUFWAXPRSA-N 0.000 claims 1
- DNXHEGUUPJUMQT-CBZIJGRNSA-N Estrone Chemical compound OC1=CC=C2[C@H]3CC[C@](C)(C(CC4)=O)[C@@H]4[C@@H]3CCC2=C1 DNXHEGUUPJUMQT-CBZIJGRNSA-N 0.000 claims 1
- BFPYWIDHMRZLRN-SLHNCBLASA-N Ethinyl estradiol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@](CC4)(O)C#C)[C@@H]4[C@@H]3CCC2=C1 BFPYWIDHMRZLRN-SLHNCBLASA-N 0.000 claims 1
- QGXBDMJGAMFCBF-UHFFFAOYSA-N Etiocholanolone Natural products C1C(O)CCC2(C)C3CCC(C)(C(CC4)=O)C4C3CCC21 QGXBDMJGAMFCBF-UHFFFAOYSA-N 0.000 claims 1
- WRWBCPJQPDHXTJ-DTMQFJJTSA-N Methandriol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@](C)(O)[C@@]1(C)CC2 WRWBCPJQPDHXTJ-DTMQFJJTSA-N 0.000 claims 1
- XWALNWXLMVGSFR-HLXURNFRSA-N Methandrostenolone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@](C)(O)[C@@]1(C)CC2 XWALNWXLMVGSFR-HLXURNFRSA-N 0.000 claims 1
- GCKMFJBGXUYNAG-HLXURNFRSA-N Methyltestosterone Chemical compound C1CC2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@](C)(O)[C@@]1(C)CC2 GCKMFJBGXUYNAG-HLXURNFRSA-N 0.000 claims 1
- ICTXHFFSOAJUMG-SLHNCBLASA-N Norethynodrel Chemical compound C1CC(=O)CC2=C1[C@H]1CC[C@](C)([C@](CC3)(O)C#C)[C@@H]3[C@@H]1CC2 ICTXHFFSOAJUMG-SLHNCBLASA-N 0.000 claims 1
- QSLJIVKCVHQPLV-PEMPUTJUSA-N Oxandrin Chemical compound C([C@@H]1CC2)C(=O)OC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@](C)(O)[C@@]2(C)CC1 QSLJIVKCVHQPLV-PEMPUTJUSA-N 0.000 claims 1
- HUMXXHTVHHLNRO-KAJVQRHHSA-N Prednisolone tebutate Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@@](C(=O)COC(=O)CC(C)(C)C)(O)[C@@]1(C)C[C@@H]2O HUMXXHTVHHLNRO-KAJVQRHHSA-N 0.000 claims 1
- ORNBQBCIOKFOEO-YQUGOWONSA-N Pregnenolone Natural products O=C(C)[C@@H]1[C@@]2(C)[C@H]([C@H]3[C@@H]([C@]4(C)C(=CC3)C[C@@H](O)CC4)CC2)CC1 ORNBQBCIOKFOEO-YQUGOWONSA-N 0.000 claims 1
- PDMMFKSKQVNJMI-BLQWBTBKSA-N Testosterone propionate Chemical compound C1CC2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H](OC(=O)CC)[C@@]1(C)CC2 PDMMFKSKQVNJMI-BLQWBTBKSA-N 0.000 claims 1
- XGMPVBXKDAHORN-RBWIMXSLSA-N Triamcinolone diacetate Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@@H](OC(C)=O)[C@@](C(=O)COC(=O)C)(O)[C@@]1(C)C[C@@H]2O XGMPVBXKDAHORN-RBWIMXSLSA-N 0.000 claims 1
- HKUKRSLIEVXDMS-APDHKMKFSA-N [(8r,9s,13s,14s)-13-methyl-17-oxo-7,8,9,11,12,14,15,16-octahydro-6h-cyclopenta[a]phenanthren-3-yl] benzoate Chemical compound C([C@@H]1[C@@H](C2=CC=3)CC[C@]4([C@H]1CCC4=O)C)CC2=CC=3OC(=O)C1=CC=CC=C1 HKUKRSLIEVXDMS-APDHKMKFSA-N 0.000 claims 1
- FPVRUILUEYSIMD-RPRRAYFGSA-N [(8s,9r,10s,11s,13s,14s,16r,17r)-9-fluoro-11-hydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl] acetate Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@@H](C)[C@@](C(=O)CO)(OC(C)=O)[C@@]1(C)C[C@@H]2O FPVRUILUEYSIMD-RPRRAYFGSA-N 0.000 claims 1
- RACDDTQBAFEERP-PLTZVPCUSA-N [2-[(6s,8s,9s,10r,13s,14s,17r)-6-chloro-17-hydroxy-10,13-dimethyl-3,11-dioxo-6,7,8,9,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl]-2-oxoethyl] acetate Chemical compound C1([C@@H](Cl)C2)=CC(=O)C=C[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@@](C(=O)COC(=O)C)(O)[C@@]2(C)CC1=O RACDDTQBAFEERP-PLTZVPCUSA-N 0.000 claims 1
- PHEOVVDXTQVHAZ-XDANTLIUSA-N [2-[(8s,9s,10r,11s,13s,14s,17r)-11,17-dihydroxy-10,13-dimethyl-3-oxo-7,8,9,11,12,14,15,16-octahydro-6h-cyclopenta[a]phenanthren-17-yl]-2-oxoethyl] 2,2-dimethylpropanoate Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@@](C(=O)COC(=O)C(C)(C)C)(O)[C@@]1(C)C[C@@H]2O PHEOVVDXTQVHAZ-XDANTLIUSA-N 0.000 claims 1
- 229940022663 acetate Drugs 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 229960002478 aldosterone Drugs 0.000 claims 1
- 230000001195 anabolic effect Effects 0.000 claims 1
- 238000009165 androgen replacement therapy Methods 0.000 claims 1
- 229940061641 androsterone Drugs 0.000 claims 1
- 229960004648 betamethasone acetate Drugs 0.000 claims 1
- AKUJBENLRBOFTD-QZIXMDIESA-N betamethasone acetate Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@H](C)[C@@](C(=O)COC(C)=O)(O)[C@@]1(C)C[C@@H]2O AKUJBENLRBOFTD-QZIXMDIESA-N 0.000 claims 1
- 229960001616 chlormadinone acetate Drugs 0.000 claims 1
- OMFXVFTZEKFJBZ-HJTSIMOOSA-N corticosterone Chemical compound O=C1CC[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@H](CC4)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 OMFXVFTZEKFJBZ-HJTSIMOOSA-N 0.000 claims 1
- ALEXXDVDDISNDU-JZYPGELDSA-N cortisol 21-acetate Chemical compound C1CC2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@@](C(=O)COC(=O)C)(O)[C@@]1(C)C[C@@H]2O ALEXXDVDDISNDU-JZYPGELDSA-N 0.000 claims 1
- BGSOJVFOEQLVMH-VWUMJDOOSA-N cortisol phosphate Chemical compound O=C1CC[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)COP(O)(O)=O)[C@@H]4[C@@H]3CCC2=C1 BGSOJVFOEQLVMH-VWUMJDOOSA-N 0.000 claims 1
- 229960004544 cortisone Drugs 0.000 claims 1
- 229960003290 cortisone acetate Drugs 0.000 claims 1
- ZESRJSPZRDMNHY-UHFFFAOYSA-N de-oxy corticosterone Natural products O=C1CCC2(C)C3CCC(C)(C(CC4)C(=O)CO)C4C3CCC2=C1 ZESRJSPZRDMNHY-UHFFFAOYSA-N 0.000 claims 1
- 230000002950 deficient Effects 0.000 claims 1
- 229960004486 desoxycorticosterone acetate Drugs 0.000 claims 1
- 229950008390 desoxycorticosterone pivalate Drugs 0.000 claims 1
- 229960003654 desoxycortone Drugs 0.000 claims 1
- 229960003957 dexamethasone Drugs 0.000 claims 1
- UREBDLICKHMUKA-CXSFZGCWSA-N dexamethasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@@H](C)[C@@](C(=O)CO)(O)[C@@]1(C)C[C@@H]2O UREBDLICKHMUKA-CXSFZGCWSA-N 0.000 claims 1
- 229960003657 dexamethasone acetate Drugs 0.000 claims 1
- PLCQGRYPOISRTQ-FCJDYXGNSA-L dexamethasone sodium phosphate Chemical compound [Na+].[Na+].C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@@H](C)[C@@](C(=O)COP([O-])([O-])=O)(O)[C@@]1(C)C[C@@H]2O PLCQGRYPOISRTQ-FCJDYXGNSA-L 0.000 claims 1
- 229950009888 dichlorisone Drugs 0.000 claims 1
- YNNURTVKPVJVEI-GSLJADNHSA-N dichlorisone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(Cl)[C@@H]1[C@@H]1CC[C@@](C(=O)COC(=O)C)(O)[C@@]1(C)C[C@@H]2Cl YNNURTVKPVJVEI-GSLJADNHSA-N 0.000 claims 1
- 229950006690 dimethisterone Drugs 0.000 claims 1
- BNIILDVGGAEEIG-UHFFFAOYSA-L disodium hydrogen phosphate Chemical compound [Na+].[Na+].OP([O-])([O-])=O BNIILDVGGAEEIG-UHFFFAOYSA-L 0.000 claims 1
- 238000012377 drug delivery Methods 0.000 claims 1
- JBKVHLHDHHXQEQ-UHFFFAOYSA-N epsilon-caprolactam Chemical compound O=C1CCCCCN1 JBKVHLHDHHXQEQ-UHFFFAOYSA-N 0.000 claims 1
- 229960005309 estradiol Drugs 0.000 claims 1
- 229930182833 estradiol Natural products 0.000 claims 1
- 229950002007 estradiol benzoate Drugs 0.000 claims 1
- 229960005416 estradiol cypionate Drugs 0.000 claims 1
- 229950010215 estradiol dipropionate Drugs 0.000 claims 1
- PROQIPRRNZUXQM-ZXXIGWHRSA-N estriol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@H]([C@H](O)C4)O)[C@@H]4[C@@H]3CCC2=C1 PROQIPRRNZUXQM-ZXXIGWHRSA-N 0.000 claims 1
- 229960001348 estriol Drugs 0.000 claims 1
- 229960003399 estrone Drugs 0.000 claims 1
- 229960002568 ethinylestradiol Drugs 0.000 claims 1
- CHNXZKVNWQUJIB-CEGNMAFCSA-N ethisterone Chemical compound O=C1CC[C@]2(C)[C@H]3CC[C@](C)([C@](CC4)(O)C#C)[C@@H]4[C@@H]3CCC2=C1 CHNXZKVNWQUJIB-CEGNMAFCSA-N 0.000 claims 1
- 229960000445 ethisterone Drugs 0.000 claims 1
- ONKUMRGIYFNPJW-KIEAKMPYSA-N ethynodiol diacetate Chemical compound C1C[C@]2(C)[C@@](C#C)(OC(C)=O)CC[C@H]2[C@@H]2CCC3=C[C@@H](OC(=O)C)CC[C@@H]3[C@H]21 ONKUMRGIYFNPJW-KIEAKMPYSA-N 0.000 claims 1
- 230000035558 fertility Effects 0.000 claims 1
- AAXVEMMRQDVLJB-BULBTXNYSA-N fludrocortisone Chemical compound O=C1CC[C@]2(C)[C@@]3(F)[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 AAXVEMMRQDVLJB-BULBTXNYSA-N 0.000 claims 1
- 229960002011 fludrocortisone Drugs 0.000 claims 1
- SYWHXTATXSMDSB-GSLJADNHSA-N fludrocortisone acetate Chemical compound C1CC2=CC(=O)CC[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1CC[C@@](C(=O)COC(=O)C)(O)[C@@]1(C)C[C@@H]2O SYWHXTATXSMDSB-GSLJADNHSA-N 0.000 claims 1
- 229960000676 flunisolide Drugs 0.000 claims 1
- 229960001347 fluocinolone acetonide Drugs 0.000 claims 1
- FEBLZLNTKCEFIT-VSXGLTOVSA-N fluocinolone acetonide Chemical compound C1([C@@H](F)C2)=CC(=O)C=C[C@]1(C)[C@]1(F)[C@@H]2[C@@H]2C[C@H]3OC(C)(C)O[C@@]3(C(=O)CO)[C@@]2(C)C[C@@H]1O FEBLZLNTKCEFIT-VSXGLTOVSA-N 0.000 claims 1
- 229960003336 fluorocortisol acetate Drugs 0.000 claims 1
- 229960001048 fluorometholone Drugs 0.000 claims 1
- FAOZLTXFLGPHNG-KNAQIMQKSA-N fluorometholone Chemical compound C([C@@]12C)=CC(=O)C=C1[C@@H](C)C[C@@H]1[C@]2(F)[C@@H](O)C[C@]2(C)[C@@](O)(C(C)=O)CC[C@H]21 FAOZLTXFLGPHNG-KNAQIMQKSA-N 0.000 claims 1
- YLRFCQOZQXIBAB-RBZZARIASA-N fluoxymesterone Chemical compound C1CC2=CC(=O)CC[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1CC[C@](C)(O)[C@@]1(C)C[C@@H]2O YLRFCQOZQXIBAB-RBZZARIASA-N 0.000 claims 1
- 229960001751 fluoxymesterone Drugs 0.000 claims 1
- 229960000618 fluprednisolone Drugs 0.000 claims 1
- JKQQZJHNUVDHKP-SZMVRVGJSA-N flurogestone acetate Chemical compound C1CC2=CC(=O)CC[C@]2(C)[C@@]2(F)[C@H]1[C@H]1CC[C@@](C(C)=O)(OC(=O)C)[C@]1(C)C[C@@H]2O JKQQZJHNUVDHKP-SZMVRVGJSA-N 0.000 claims 1
- 239000003862 glucocorticoid Substances 0.000 claims 1
- 238000002657 hormone replacement therapy Methods 0.000 claims 1
- 229960001067 hydrocortisone acetate Drugs 0.000 claims 1
- 229960004204 hydrocortisone sodium phosphate Drugs 0.000 claims 1
- 229960001401 hydrocortisone sodium succinate Drugs 0.000 claims 1
- 229960002899 hydroxyprogesterone Drugs 0.000 claims 1
- 229940065346 hydroxyprogesterone acetate Drugs 0.000 claims 1
- 229960003846 melengestrol acetate Drugs 0.000 claims 1
- 229960001390 mestranol Drugs 0.000 claims 1
- IMSSROKUHAOUJS-MJCUULBUSA-N mestranol Chemical compound C1C[C@]2(C)[C@@](C#C)(O)CC[C@H]2[C@@H]2CCC3=CC(OC)=CC=C3[C@H]21 IMSSROKUHAOUJS-MJCUULBUSA-N 0.000 claims 1
- 229960003377 metandienone Drugs 0.000 claims 1
- 229960004584 methylprednisolone Drugs 0.000 claims 1
- 229960001293 methylprednisolone acetate Drugs 0.000 claims 1
- PLBHSZGDDKCEHR-LFYFAGGJSA-N methylprednisolone acetate Chemical compound C([C@@]12C)=CC(=O)C=C1[C@@H](C)C[C@@H]1[C@@H]2[C@@H](O)C[C@]2(C)[C@@](O)(C(=O)COC(C)=O)CC[C@H]21 PLBHSZGDDKCEHR-LFYFAGGJSA-N 0.000 claims 1
- 229960001566 methyltestosterone Drugs 0.000 claims 1
- ZDHCJEIGTNNEMY-XGXHKTLJSA-N norethandrolone Chemical compound C1CC2=CC(=O)CC[C@@H]2[C@@H]2[C@@H]1[C@@H]1CC[C@](CC)(O)[C@@]1(C)CC2 ZDHCJEIGTNNEMY-XGXHKTLJSA-N 0.000 claims 1
- 229960000492 norethandrolone Drugs 0.000 claims 1
- 229940053934 norethindrone Drugs 0.000 claims 1
- VIKNJXKGJWUCNN-XGXHKTLJSA-N norethisterone Chemical compound O=C1CC[C@@H]2[C@H]3CC[C@](C)([C@](CC4)(O)C#C)[C@@H]4[C@@H]3CCC2=C1 VIKNJXKGJWUCNN-XGXHKTLJSA-N 0.000 claims 1
- 229960001858 norethynodrel Drugs 0.000 claims 1
- 229960000464 oxandrolone Drugs 0.000 claims 1
- 229960005244 oxymetholone Drugs 0.000 claims 1
- ICMWWNHDUZJFDW-DHODBPELSA-N oxymetholone Chemical compound C([C@@H]1CC2)C(=O)\C(=C/O)C[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@](C)(O)[C@@]2(C)CC1 ICMWWNHDUZJFDW-DHODBPELSA-N 0.000 claims 1
- ICMWWNHDUZJFDW-UHFFFAOYSA-N oxymetholone Natural products C1CC2CC(=O)C(=CO)CC2(C)C2C1C1CCC(C)(O)C1(C)CC2 ICMWWNHDUZJFDW-UHFFFAOYSA-N 0.000 claims 1
- 239000003961 penetration enhancing agent Substances 0.000 claims 1
- 229960004259 prednisolone tebutate Drugs 0.000 claims 1
- 229960004618 prednisone Drugs 0.000 claims 1
- XOFYZVNMUHMLCC-ZPOLXVRWSA-N prednisone Chemical compound O=C1C=C[C@]2(C)[C@H]3C(=O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 XOFYZVNMUHMLCC-ZPOLXVRWSA-N 0.000 claims 1
- 229960000249 pregnenolone Drugs 0.000 claims 1
- ORNBQBCIOKFOEO-QGVNFLHTSA-N pregnenolone Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H](C(=O)C)[C@@]1(C)CC2 ORNBQBCIOKFOEO-QGVNFLHTSA-N 0.000 claims 1
- 229940002612 prodrug Drugs 0.000 claims 1
- 239000000651 prodrug Substances 0.000 claims 1
- 239000000186 progesterone Substances 0.000 claims 1
- 229960003387 progesterone Drugs 0.000 claims 1
- 239000000583 progesterone congener Substances 0.000 claims 1
- 230000001737 promoting effect Effects 0.000 claims 1
- 239000003380 propellant Substances 0.000 claims 1
- MIXMJCQRHVAJIO-TZHJZOAOSA-N qk4dys664x Chemical compound O.C1([C@@H](F)C2)=CC(=O)C=C[C@]1(C)[C@@H]1[C@@H]2[C@@H]2C[C@H]3OC(C)(C)O[C@@]3(C(=O)CO)[C@@]2(C)C[C@@H]1O.C1([C@@H](F)C2)=CC(=O)C=C[C@]1(C)[C@@H]1[C@@H]2[C@@H]2C[C@H]3OC(C)(C)O[C@@]3(C(=O)CO)[C@@]2(C)C[C@@H]1O MIXMJCQRHVAJIO-TZHJZOAOSA-N 0.000 claims 1
- 230000001105 regulatory effect Effects 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 230000036299 sexual function Effects 0.000 claims 1
- BFQDICGJHAONBN-OOFWROCWSA-M sodium;4-[2-[(5r,8r,9s,10s,13s,14s,17s)-10,13-dimethyl-3-oxo-1,2,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydrocyclopenta[a]phenanthren-17-yl]-2-oxoethoxy]-4-oxobutanoate Chemical compound [Na+].C1C(=O)CC[C@]2(C)[C@H]3CC[C@](C)([C@H](CC4)C(=O)COC(=O)CCC([O-])=O)[C@@H]4[C@@H]3CC[C@@H]21 BFQDICGJHAONBN-OOFWROCWSA-M 0.000 claims 1
- LXMSZDCAJNLERA-ZHYRCANASA-N spironolactone Chemical compound C([C@@H]1[C@]2(C)CC[C@@H]3[C@@]4(C)CCC(=O)C=C4C[C@H]([C@@H]13)SC(=O)C)C[C@@]21CCC(=O)O1 LXMSZDCAJNLERA-ZHYRCANASA-N 0.000 claims 1
- 229960002256 spironolactone Drugs 0.000 claims 1
- 230000003637 steroidlike Effects 0.000 claims 1
- VOCBWIIFXDYGNZ-IXKNJLPQSA-N testosterone enanthate Chemical compound C1CC2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H](OC(=O)CCCCCC)[C@@]1(C)CC2 VOCBWIIFXDYGNZ-IXKNJLPQSA-N 0.000 claims 1
- 229960003484 testosterone enanthate Drugs 0.000 claims 1
- 229960001712 testosterone propionate Drugs 0.000 claims 1
- 229960004320 triamcinolone diacetate Drugs 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US98478707P | 2007-11-02 | 2007-11-02 | |
| PCT/AU2008/001613 WO2009055859A1 (en) | 2007-11-02 | 2008-10-31 | Transdermal delivery system for hormones and steroids |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2011502172A JP2011502172A (ja) | 2011-01-20 |
| JP2011502172A5 true JP2011502172A5 (enExample) | 2011-12-08 |
Family
ID=40590452
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010532377A Expired - Fee Related JP5737942B2 (ja) | 2007-11-02 | 2008-10-31 | 経皮送達システム |
| JP2010532376A Ceased JP2011502172A (ja) | 2007-11-02 | 2008-10-31 | ホルモンおよびステロイド用の経皮送達システム |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010532377A Expired - Fee Related JP5737942B2 (ja) | 2007-11-02 | 2008-10-31 | 経皮送達システム |
Country Status (17)
| Country | Link |
|---|---|
| US (5) | US20100279988A1 (enExample) |
| EP (2) | EP2214643B1 (enExample) |
| JP (2) | JP5737942B2 (enExample) |
| KR (2) | KR101662186B1 (enExample) |
| CN (2) | CN101883556B (enExample) |
| AU (2) | AU2008318284B2 (enExample) |
| BR (2) | BRPI0819245A2 (enExample) |
| CA (2) | CA2704117C (enExample) |
| DK (2) | DK2219603T3 (enExample) |
| EA (2) | EA019760B1 (enExample) |
| ES (2) | ES2466676T3 (enExample) |
| MX (2) | MX2010004788A (enExample) |
| NZ (2) | NZ585033A (enExample) |
| PL (2) | PL2214643T3 (enExample) |
| PT (2) | PT2219603E (enExample) |
| WO (2) | WO2009055859A1 (enExample) |
| ZA (1) | ZA201003553B (enExample) |
Families Citing this family (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR068409A1 (es) * | 2007-09-14 | 2009-11-18 | Drugtech Corp | Composiciones farmaceuticas, transdermicas sin alcohol |
| AR068408A1 (es) * | 2007-09-14 | 2009-11-18 | Drugtech Corp | Pulverizacion de hormonas transdermicas |
| CN101883556B (zh) * | 2007-11-02 | 2013-05-29 | 艾克若克斯Dds有限公司 | 激素和类固醇的透皮递送系统 |
| EP2650019B1 (en) * | 2010-12-07 | 2015-08-05 | Yutoku Pharmaceutical Industries Co., Ltd. | Noradrenergic and specific serotonergic antidepressant-containing transdermal patch |
| HRP20211377T1 (hr) | 2011-11-23 | 2022-01-07 | Therapeuticsmd, Inc. | Prirodne kombinirane hormonske supstitucijske formulacije i terapije |
| US9301920B2 (en) | 2012-06-18 | 2016-04-05 | Therapeuticsmd, Inc. | Natural combination hormone replacement formulations and therapies |
| JPWO2013183407A1 (ja) * | 2012-06-05 | 2016-01-28 | 祐徳薬品工業株式会社 | ミルタザピン含有経皮吸収型貼付製剤 |
| US20130338122A1 (en) | 2012-06-18 | 2013-12-19 | Therapeuticsmd, Inc. | Transdermal hormone replacement therapies |
| US10806740B2 (en) | 2012-06-18 | 2020-10-20 | Therapeuticsmd, Inc. | Natural combination hormone replacement formulations and therapies |
| US10806697B2 (en) | 2012-12-21 | 2020-10-20 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US20150196640A1 (en) | 2012-06-18 | 2015-07-16 | Therapeuticsmd, Inc. | Progesterone formulations having a desirable pk profile |
| US9180091B2 (en) | 2012-12-21 | 2015-11-10 | Therapeuticsmd, Inc. | Soluble estradiol capsule for vaginal insertion |
| US10471072B2 (en) | 2012-12-21 | 2019-11-12 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US11246875B2 (en) | 2012-12-21 | 2022-02-15 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US10537581B2 (en) | 2012-12-21 | 2020-01-21 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US11266661B2 (en) | 2012-12-21 | 2022-03-08 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US10568891B2 (en) | 2012-12-21 | 2020-02-25 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US10201549B2 (en) * | 2013-06-14 | 2019-02-12 | Professional Compounding Centers Of America (Pcca) | Testosterone combined with anastrozole injection solutions |
| US20150065426A1 (en) * | 2013-08-27 | 2015-03-05 | Professional Compounding Centers Of America | Testosterone Booster Transdermal Compositions |
| AU2015256473B2 (en) * | 2014-05-05 | 2018-07-12 | Allergan pharmaceuticals International Ltd. | Formulations and methods for vaginal delivery of antiprogestins |
| KR20170005819A (ko) | 2014-05-22 | 2017-01-16 | 쎄러퓨틱스엠디, 인코퍼레이티드 | 천연 복합 호르몬 대체 제형 및 요법 |
| CA3013771C (en) | 2015-02-27 | 2024-01-02 | Kindred Biosciences, Inc. | Stimulation of appetite, management of weight loss, and treatment of anorexia in dogs and cats |
| JP6784442B2 (ja) | 2015-04-13 | 2020-11-11 | エルジー ハウスホールド アンド ヘルスケア リミテッド | 神経伝達物質の排出を調節する成分が含まれた溶解性マイクロニドル |
| WO2016167545A1 (ko) * | 2015-04-13 | 2016-10-20 | 주식회사 엘지생활건강 | 신경전달물질의 배출을 조절하는 성분이 포함된 용해성 마이크로니들 |
| CA2986039A1 (en) | 2015-05-18 | 2016-11-24 | Agile Therapeutics, Inc. | Contraceptive compositions and methods for improved efficacy and modulation of side effects |
| US10328087B2 (en) | 2015-07-23 | 2019-06-25 | Therapeuticsmd, Inc. | Formulations for solubilizing hormones |
| US10449201B2 (en) * | 2015-08-17 | 2019-10-22 | Alpha To Omega Pharmaceutical Consultants, Inc. | Transdermal and/or topical delivery system comprising clobazam |
| GB201604484D0 (en) | 2016-03-16 | 2016-04-27 | Antibiotx Aps And Københavns Uni University Of Copenhagen | Topical antibacterial compositions |
| KR20180126582A (ko) | 2016-04-01 | 2018-11-27 | 쎄러퓨틱스엠디, 인코퍼레이티드 | 스테로이드 호르몬 약제학적 조성물 |
| WO2017173044A1 (en) | 2016-04-01 | 2017-10-05 | Therapeuticsmd Inc. | Steroid hormone compositions in medium chain oils |
| WO2018031576A1 (en) * | 2016-08-08 | 2018-02-15 | Baucom Karan Y | Hormone delivery system and method |
| WO2018091688A1 (en) * | 2016-11-17 | 2018-05-24 | Cytoo | Skeletal muscle hypertrophy inducers |
| KR102436756B1 (ko) * | 2017-01-31 | 2022-08-29 | 신신제약 주식회사 | 비스테로이드계 소염진통제와 살리실산 유도체를 포함하는 경피흡수 제제 |
| GB2560365B (en) | 2017-03-09 | 2021-10-20 | Brightwake Ltd | Improvements relating to apparatus negative pressure wound therapy |
| CN107929268A (zh) * | 2017-12-19 | 2018-04-20 | 郑州泰丰制药有限公司 | 一种含质子泵抑制剂药物的透皮贴剂及其制备方法 |
| WO2019140087A1 (en) * | 2018-01-10 | 2019-07-18 | Celista Pharmaceuticals Llc | Testosterone transdermal spray with film |
| US10285998B1 (en) | 2018-04-04 | 2019-05-14 | The Menopause Method, Inc. | Composition and method to aid in hormone replacement therapy |
| CN108703942B (zh) * | 2018-04-23 | 2021-04-06 | 中山大学 | 载有纳米材料包裹保胎药物的微针给药系统及制备方法 |
| WO2020010205A1 (en) | 2018-07-05 | 2020-01-09 | Celista Pharmaceuticals Llc | Testosterone and estradiol transdermal spray |
| CN110947088A (zh) * | 2019-12-06 | 2020-04-03 | 广州新济薇娜生物科技有限公司 | 护眼组合贴片及其制备方法 |
| KR102592892B1 (ko) | 2021-03-12 | 2023-10-23 | 충남대학교산학협력단 | 데속시코르티코스테론 글루코사이드를 포함하는 당뇨병 예방 또는 치료용 조성물 |
Family Cites Families (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK534178A (da) | 1977-12-16 | 1979-06-17 | Interx Research Corp | Anticholinerge midler med sektrtionshaemmende virkning |
| US5196410A (en) * | 1986-10-31 | 1993-03-23 | Pfizer Inc. | Transdermal flux enhancing compositions |
| US4906475A (en) * | 1988-02-16 | 1990-03-06 | Paco Pharmaceutical Services | Estradiol transdermal delivery system |
| JPH01308225A (ja) * | 1988-06-03 | 1989-12-12 | Nissan Chem Ind Ltd | 外用医薬組成物 |
| DE69007886T2 (de) * | 1989-07-21 | 1994-11-17 | Izhak Blank | Östradiol enthaltende Mittel und Verfahren zur topischen Anwendung. |
| US5276079A (en) * | 1991-11-15 | 1994-01-04 | Minnesota Mining And Manufacturing Company | Pressure-sensitive poly(n-vinyl lactam) adhesive composition and method for producing and using same |
| JP3756512B2 (ja) * | 1992-09-21 | 2006-03-15 | ファルマシア・アンド・アップジョン・カンパニー・エルエルシー | 徐放性タンパク質製剤 |
| AU5294393A (en) * | 1992-10-06 | 1994-04-26 | Upjohn Company, The | Topical pharmaceutical compositions |
| AUPN814496A0 (en) * | 1996-02-19 | 1996-03-14 | Monash University | Dermal penetration enhancer |
| US6923983B2 (en) * | 1996-02-19 | 2005-08-02 | Acrux Dds Pty Ltd | Transdermal delivery of hormones |
| US7094422B2 (en) * | 1996-02-19 | 2006-08-22 | Acrux Dds Pty Ltd. | Topical delivery of antifungal agents |
| US6998138B2 (en) * | 1996-02-19 | 2006-02-14 | Acrux Dds Pty. Ltd. | Topical delivery of anti-alopecia agents |
| US6916486B2 (en) * | 1996-02-19 | 2005-07-12 | Acrux Dds Pty Ltd | Transdermal delivery of analgesics |
| US6916487B2 (en) * | 1996-02-19 | 2005-07-12 | Acrux Dds Pty Ltd | Transdermal delivery of antiemetics |
| US6929801B2 (en) * | 1996-02-19 | 2005-08-16 | Acrux Dds Pty Ltd | Transdermal delivery of antiparkinson agents |
| GB9902227D0 (en) * | 1999-02-01 | 1999-03-24 | Cipla Limited | Pharmaceutical composition for topical administration |
| ID30353A (id) * | 1999-02-05 | 2001-11-22 | Cipla Ltd | Obat semprot topikal |
| AU6019900A (en) * | 1999-11-24 | 2001-06-04 | Sumika Fine Chemicals Co., Ltd. | Anhydrous mirtazapine crystals and process for producing the same |
| WO2001052855A2 (en) * | 2000-01-19 | 2001-07-26 | Akzo Nobel N.V. | Drug combination for the treatment of depression and related disorders comprising mirtazapine and gepirone |
| BR0214009A (pt) * | 2001-11-09 | 2004-11-03 | Quadra Logic Tech Inc | Método e composição para estimular o crescimento de pelos sobre a pele |
| US20050181032A1 (en) * | 2002-06-25 | 2005-08-18 | Acrux Dds Pty Ltd. | Metastable pharmaceutical compositions |
| AUPS317102A0 (en) * | 2002-06-25 | 2002-07-18 | Drug Delivery Solutions Pty Ltd | Transdermal aerosol compositions |
| US20050186141A1 (en) * | 2002-06-25 | 2005-08-25 | Acrux Dds Pty Ltd. | Transdermal aerosol compositions |
| CA2489865C (en) * | 2002-06-25 | 2012-05-08 | Acrux Dds Pty Ltd | Transdermal delivery rate control using amorphous pharmaceutical compositions |
| US20060018937A1 (en) * | 2002-10-25 | 2006-01-26 | Foamix Ltd. | Steroid kit and foamable composition and uses thereof |
| US7704518B2 (en) * | 2003-08-04 | 2010-04-27 | Foamix, Ltd. | Foamable vehicle and pharmaceutical compositions thereof |
| CA2433101A1 (en) * | 2003-06-23 | 2004-12-23 | Igor Gonda | Method of treatment of a female suffering from androgen insufficiency |
| AU2004290463A1 (en) * | 2003-11-19 | 2005-06-02 | Acrux Dds Pty Ltd | Method and composition for treatment of cutaneous lesions |
| AU2004290464A1 (en) * | 2003-11-19 | 2005-06-02 | Acrux Dds Pty Ltd | Method and composition for treatment or prophylaxis of amyloidosis disorders |
| CN102134231B (zh) | 2004-03-15 | 2020-08-04 | 武田药品工业株式会社 | 二肽基肽酶抑制剂 |
| JP4613622B2 (ja) * | 2005-01-20 | 2011-01-19 | 住友電気工業株式会社 | 軟磁性材料および圧粉磁心 |
| US20070088012A1 (en) * | 2005-04-08 | 2007-04-19 | Woun Seo | Method of treating or preventing type-2 diabetes |
| US20070154533A1 (en) * | 2005-04-13 | 2007-07-05 | Dudley Robert E | Method of increasing testosterone and related steriod concentrations in women |
| WO2006124681A2 (en) * | 2005-05-18 | 2006-11-23 | The Gi Company, Inc. | Oral drug delivery system and methods of use thereof |
| CA2610708C (en) * | 2005-06-03 | 2013-10-08 | Acrux Dds Pty Ltd | Method and composition for transdermal drug delivery |
| BRPI0611134A2 (pt) * | 2005-06-03 | 2010-08-17 | Acrux Dds Pty Ltd | método e composição para liberação transdérmica de fármaco |
| WO2007016766A1 (en) * | 2005-08-05 | 2007-02-15 | Nuvo Research Inc. | Transdermal drug delivery formulation |
| CN101287470B (zh) * | 2005-10-12 | 2012-10-17 | 优尼麦德药物股份有限公司 | 改良的睾酮凝胶及使用方法 |
| WO2008073684A1 (en) * | 2006-12-08 | 2008-06-19 | Lipo Chemicals Inc. | Composition for treating aging skin comprising a hydroxycinnamic acid such as p-coumaric acid |
| CN101883556B (zh) * | 2007-11-02 | 2013-05-29 | 艾克若克斯Dds有限公司 | 激素和类固醇的透皮递送系统 |
| JP5675175B2 (ja) * | 2009-06-23 | 2015-02-25 | 大陽日酸株式会社 | オゾン供給装置 |
-
2008
- 2008-10-31 CN CN2008801187639A patent/CN101883556B/zh not_active Expired - Fee Related
- 2008-10-31 US US12/740,666 patent/US20100279988A1/en not_active Abandoned
- 2008-10-31 BR BRPI0819245A patent/BRPI0819245A2/pt not_active IP Right Cessation
- 2008-10-31 EP EP08845547.2A patent/EP2214643B1/en not_active Not-in-force
- 2008-10-31 NZ NZ585033A patent/NZ585033A/en not_active IP Right Cessation
- 2008-10-31 EP EP08845600.9A patent/EP2219603B1/en not_active Not-in-force
- 2008-10-31 DK DK08845600.9T patent/DK2219603T3/da active
- 2008-10-31 CN CN2008801187624A patent/CN101888830B/zh not_active Expired - Fee Related
- 2008-10-31 WO PCT/AU2008/001613 patent/WO2009055859A1/en not_active Ceased
- 2008-10-31 PL PL08845547T patent/PL2214643T3/pl unknown
- 2008-10-31 ES ES08845547.2T patent/ES2466676T3/es active Active
- 2008-10-31 CA CA2704117A patent/CA2704117C/en not_active Expired - Fee Related
- 2008-10-31 BR BRPI0819235A patent/BRPI0819235A2/pt not_active IP Right Cessation
- 2008-10-31 NZ NZ585034A patent/NZ585034A/en not_active IP Right Cessation
- 2008-10-31 PT PT88456009T patent/PT2219603E/pt unknown
- 2008-10-31 PL PL08845600T patent/PL2219603T3/pl unknown
- 2008-10-31 WO PCT/AU2008/001614 patent/WO2009055860A1/en not_active Ceased
- 2008-10-31 DK DK08845547.2T patent/DK2214643T3/da active
- 2008-10-31 EA EA201000746A patent/EA019760B1/ru not_active IP Right Cessation
- 2008-10-31 ES ES08845600.9T patent/ES2494853T3/es active Active
- 2008-10-31 JP JP2010532377A patent/JP5737942B2/ja not_active Expired - Fee Related
- 2008-10-31 CA CA2704116A patent/CA2704116A1/en not_active Abandoned
- 2008-10-31 PT PT88455472T patent/PT2214643E/pt unknown
- 2008-10-31 KR KR1020107012100A patent/KR101662186B1/ko not_active Expired - Fee Related
- 2008-10-31 AU AU2008318284A patent/AU2008318284B2/en not_active Ceased
- 2008-10-31 MX MX2010004788A patent/MX2010004788A/es active IP Right Grant
- 2008-10-31 EA EA201000747A patent/EA201000747A1/ru unknown
- 2008-10-31 US US12/740,663 patent/US20100297032A1/en not_active Abandoned
- 2008-10-31 JP JP2010532376A patent/JP2011502172A/ja not_active Ceased
- 2008-10-31 MX MX2010004789A patent/MX2010004789A/es active IP Right Grant
- 2008-10-31 KR KR1020107012099A patent/KR20100094495A/ko not_active Ceased
- 2008-10-31 AU AU2008318283A patent/AU2008318283B2/en not_active Ceased
-
2010
- 2010-05-19 ZA ZA2010/03553A patent/ZA201003553B/en unknown
-
2013
- 2013-05-06 US US13/887,758 patent/US9078810B2/en not_active Expired - Fee Related
- 2013-05-06 US US13/887,719 patent/US20130317462A1/en not_active Abandoned
-
2015
- 2015-06-10 US US14/735,428 patent/US20160022820A1/en not_active Abandoned
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2011502172A5 (enExample) | ||
| EP2214643B1 (en) | Transdermal delivery system for hormones and steroids | |
| CN100391462C (zh) | 增强的透皮给药系统 | |
| Africander et al. | Molecular mechanisms of steroid receptor-mediated actions by synthetic progestins used in HRT and contraception | |
| KR960704578A (ko) | 모노글리세리드/락테이트 에스테르 투과 촉진제(Monoglyceride/Lactate Ester Permeation Enhancer) | |
| US6465005B1 (en) | Inhibition of crystallization in transdermal devices | |
| JP3422796B2 (ja) | ステロイドの安定性を向上させるための薬剤放出組成物 | |
| DK2473161T3 (en) | TOPICAL FORMULATIONS INCLUDING A STEROID | |
| CN106659682B (zh) | 外用皮质类固醇组合物 | |
| JP2003502357A5 (enExample) | ||
| CA2606933A1 (en) | Steroid kit and foamable composition and uses thereof | |
| WO2011073995A2 (en) | Liquid vaginal spray of progesterone | |
| HRP20161279T1 (hr) | Kombinirani preparati s antagonistom citokina i ortikosteroidom | |
| JP2006518382A5 (enExample) | ||
| JP2008534533A5 (enExample) | ||
| WO1995005137A1 (en) | Transdermal delivery system using a combination of permeation enhancers | |
| JP2000511921A (ja) | ２種類の活性成分を別個の区画に内容する経皮系、その製造法、および医薬としてのその用途 | |
| JP2011503109A5 (enExample) | ||
| HK1143091B (en) | Transdermal delivery system for hormones and steroids | |
| WO2019010230A1 (en) | COMPOSITIONS FOR DRUG DELIVERY | |
| WO2001089488A1 (de) | Estrogenhaltiges pflaster mit einem wirkstoffreservoir auf der basis von ethylcellulose, polyoxyethylenlaurylalcohol und einem ethylen-vinylacetatvinylpyrrolidon-copolymer |