JP2011502165A5 - - Google Patents
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- JP2011502165A5 JP2011502165A5 JP2010532246A JP2010532246A JP2011502165A5 JP 2011502165 A5 JP2011502165 A5 JP 2011502165A5 JP 2010532246 A JP2010532246 A JP 2010532246A JP 2010532246 A JP2010532246 A JP 2010532246A JP 2011502165 A5 JP2011502165 A5 JP 2011502165A5
- Authority
- JP
- Japan
- Prior art keywords
- vaccine
- seq
- human subject
- polypeptide
- polynucleotide sequence
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 229960005486 vaccine Drugs 0.000 claims 18
- 241000894006 Bacteria Species 0.000 claims 10
- 102000040430 polynucleotide Human genes 0.000 claims 10
- 108091033319 polynucleotide Proteins 0.000 claims 10
- 239000002157 polynucleotide Substances 0.000 claims 10
- 239000012634 fragment Substances 0.000 claims 5
- 230000028993 immune response Effects 0.000 claims 5
- 230000002163 immunogen Effects 0.000 claims 5
- 210000003495 flagella Anatomy 0.000 claims 4
- 229920001184 polypeptide Polymers 0.000 claims 4
- 102000004196 processed proteins & peptides Human genes 0.000 claims 4
- 108090000765 processed proteins & peptides Proteins 0.000 claims 4
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 2
- 241000607142 Salmonella Species 0.000 claims 2
- 150000001413 amino acids Chemical class 0.000 claims 2
- 229960001212 bacterial vaccine Drugs 0.000 claims 2
- 230000002708 enhancing effect Effects 0.000 claims 2
- 241000193830 Bacillus <bacterium> Species 0.000 claims 1
- 101150013553 CD40 gene Proteins 0.000 claims 1
- 241000588722 Escherichia Species 0.000 claims 1
- 241000186660 Lactobacillus Species 0.000 claims 1
- 241001354013 Salmonella enterica subsp. enterica serovar Enteritidis Species 0.000 claims 1
- 230000005867 T cell response Effects 0.000 claims 1
- 102100040245 Tumor necrosis factor receptor superfamily member 5 Human genes 0.000 claims 1
- 230000005875 antibody response Effects 0.000 claims 1
- 208000015181 infectious disease Diseases 0.000 claims 1
- 244000144977 poultry Species 0.000 claims 1
- 108091005703 transmembrane proteins Proteins 0.000 claims 1
- 102000035160 transmembrane proteins Human genes 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US98380307P | 2007-10-30 | 2007-10-30 | |
| PCT/US2008/081813 WO2009059018A1 (en) | 2007-10-30 | 2008-10-30 | Compositions and methods of enhancing immune responses to flagellated bacterium |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2011502165A JP2011502165A (ja) | 2011-01-20 |
| JP2011502165A5 true JP2011502165A5 (enExample) | 2011-12-22 |
Family
ID=40591464
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010532246A Pending JP2011502165A (ja) | 2007-10-30 | 2008-10-30 | 鞭毛細菌に対する免疫応答を強化する組成物および方法 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US9125854B2 (enExample) |
| EP (1) | EP2214840B1 (enExample) |
| JP (1) | JP2011502165A (enExample) |
| CN (1) | CN102037135A (enExample) |
| AU (1) | AU2008318615A1 (enExample) |
| BR (1) | BRPI0818736A2 (enExample) |
| CA (1) | CA2704457A1 (enExample) |
| NZ (1) | NZ585776A (enExample) |
| WO (1) | WO2009059018A1 (enExample) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2857038B1 (en) * | 2006-09-18 | 2019-04-10 | The Board of Trustees of the University of Arkansas | Compositions and methods of enhancing immune responses |
| US20080124355A1 (en) | 2006-09-22 | 2008-05-29 | David Gordon Bermudes | Live bacterial vaccines for viral infection prophylaxis or treatment |
| PT2214701T (pt) | 2007-11-01 | 2016-11-02 | Univ Guelph | Composições e métodos de potenciar respostas imunes a eimeria |
| US8647642B2 (en) | 2008-09-18 | 2014-02-11 | Aviex Technologies, Llc | Live bacterial vaccines resistant to carbon dioxide (CO2), acidic PH and/or osmolarity for viral infection prophylaxis or treatment |
| WO2011091255A1 (en) | 2010-01-21 | 2011-07-28 | The Board Of Trustees Of The University Of Arkansas | Vaccine vectors and methods of enhancing immune responses |
| CA2800830C (en) | 2010-06-09 | 2020-09-08 | The Board Of Trustees Of The University Of Arkansas | Vaccine and methods to reduce campylobacter infection |
| CA2895805A1 (en) | 2012-12-18 | 2014-06-26 | Kotzker Consulting Llc | Use of cannabinoids and terpenes for treatment of organophosphate and carbamate toxicity |
| ES2758759T3 (es) | 2013-02-14 | 2020-05-06 | Univ Arkansas | Composiciones y métodos para potenciar las respuestas inmunitarias a eimeria o limitar la infección por eimeria |
| CN105142653B (zh) | 2013-03-15 | 2019-11-15 | 阿肯色大学评议会 | 增强对肠病原体免疫应答的组合物和方法 |
| CN104789583A (zh) * | 2014-01-20 | 2015-07-22 | 华中农业大学 | 一种人源产肠毒素大肠杆菌鞭毛蛋白2FliC融合蛋白及其应用 |
| CN104328136B (zh) * | 2014-10-03 | 2018-04-17 | 哈尔滨博翱生物医药技术开发有限公司 | 鸡新城疫病毒毒株rClone30‑fliC的制备及其在鸡新城疫病防治中的应用 |
| US10676723B2 (en) | 2015-05-11 | 2020-06-09 | David Gordon Bermudes | Chimeric protein toxins for expression by therapeutic bacteria |
| JP7467027B2 (ja) | 2016-05-03 | 2024-04-15 | ザ ボード オブ トラスティーズ オブ ザ ユニバーシティ オブ アーカンソー | 免疫刺激性ポリペプチドおよび抗原性ポリペプチドを含む酵母ワクチンベクター並びにそれを使用する方法 |
| US11129906B1 (en) | 2016-12-07 | 2021-09-28 | David Gordon Bermudes | Chimeric protein toxins for expression by therapeutic bacteria |
| US11180535B1 (en) | 2016-12-07 | 2021-11-23 | David Gordon Bermudes | Saccharide binding, tumor penetration, and cytotoxic antitumor chimeric peptides from therapeutic bacteria |
| US20200216506A1 (en) * | 2017-05-12 | 2020-07-09 | Children's Medical Center Corporation | Nucleic acids that manipulate immune pathways |
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| US4420497A (en) * | 1981-08-24 | 1983-12-13 | Fairchild Camera And Instrument Corporation | Method of detecting and repairing latent defects in a semiconductor dielectric layer |
| US4510674A (en) * | 1982-10-21 | 1985-04-16 | Sovonics Solar Systems | System for eliminating short circuit current paths in photovoltaic devices |
| JP3415145B2 (ja) | 1991-03-05 | 2003-06-09 | ザ ウエルカム ファウンデーション リミテッド | 弱毒化細菌における組換えタンパク質の発現 |
| EP0667901B2 (en) | 1991-10-25 | 2008-10-15 | Immunex Corporation | Novel cytokine |
| US5981724A (en) | 1991-10-25 | 1999-11-09 | Immunex Corporation | DNA encoding CD40 ligand, a cytokine that binds CD40 |
| US7405270B2 (en) | 1991-10-25 | 2008-07-29 | Immunex Corporation | CD40-Ligand lacking native-pattern glycosylation |
| US5962406A (en) | 1991-10-25 | 1999-10-05 | Immunex Corporation | Recombinant soluble CD40 ligand polypeptide and pharmaceutical composition containing the same |
| AU683221B2 (en) | 1992-09-04 | 1997-11-06 | University Of Saskatchewan | Novel bacterial vaccines using vaccine strains of pathogenic bacteria |
| WO1995014487A1 (en) | 1993-11-24 | 1995-06-01 | The Australian National University | Treatment of viral disease with cd40l peptide |
| ATE220331T1 (de) | 1995-03-01 | 2002-07-15 | Immunex Corp | Cd40 bindendes protein zur stimulierung der immunantwort |
| IL122174A (en) | 1995-06-07 | 2004-07-25 | Immunex Corp | Dna encoding a cd40l mutein and a cd40l polypeptide encoded by said dna |
| US5800632A (en) * | 1995-09-28 | 1998-09-01 | Canon Kabushiki Kaisha | Photovoltaic device and method for manufacturing it |
| US6713279B1 (en) | 1995-12-07 | 2004-03-30 | Diversa Corporation | Non-stochastic generation of genetic vaccines and enzymes |
| US6479258B1 (en) | 1995-12-07 | 2002-11-12 | Diversa Corporation | Non-stochastic generation of genetic vaccines |
| US6306387B1 (en) | 1997-05-29 | 2001-10-23 | The Research Foundation Of State University Of New York | Antigen delivery system |
| US6969609B1 (en) | 1998-12-09 | 2005-11-29 | The United States Of America As Represented By The Department Of Health And Human Serivces | Recombinant vector expressing multiple costimulatory molecules and uses thereof |
| CA2223225A1 (en) | 1997-11-28 | 1999-05-28 | Canadian Red Cross Society | Method for inhibiting in vivo immune response |
| CA2313805A1 (en) | 1997-12-19 | 1999-07-01 | Immunex Corporation | Method for reducing susceptibility to hiv infection |
| GB9806449D0 (en) | 1998-03-25 | 1998-05-27 | Peptide Therapeutics Ltd | Attenuated bacteria useful in vaccines |
| US6190669B1 (en) | 1998-05-13 | 2001-02-20 | University Of Maryland, Baltimore | Attenuated mutants of salmonella which constitutively express the Vi antigen |
| US6248329B1 (en) * | 1998-06-01 | 2001-06-19 | Ramaswamy Chandrashekar | Parasitic helminth cuticlin nucleic acid molecules and uses thereof |
| EP1108034B1 (en) | 1998-09-04 | 2008-08-06 | Emergent Product Development UK Limited | Attenuated salmonella spi2 mutants as antigen carriers |
| US7300774B1 (en) | 1999-12-09 | 2007-11-27 | The Regents Of The University Of California | Multimeric fusion proteins of the TNF superfamily ligands |
| JP2003508016A (ja) | 1999-04-16 | 2003-03-04 | エフ．ホフマン−ラ ロシュ アーゲー | Ｃｄ４０／ｃｄ４０ｌキメラポリペプチドをコードする核酸、それらの生成方法及びそれらの使用 |
| EP1067194A1 (en) | 1999-04-16 | 2001-01-10 | F. Hoffmann-La Roche Ag | Vectors containing a gene coding for CD40 and/or CD40L under the control of a cytokine-inducible promoter which is a human acute phase amyloid A gene promoter. Methods for their production and uses thereof |
| EP1246643A4 (en) | 1999-10-14 | 2005-05-11 | Jeffery A Ledbetter | DNA VACCINES ENCODING ANTIGEN ASSOCIATED WITH CD40-BINDING DOMAIN |
| ATE269104T1 (de) * | 1999-12-28 | 2004-07-15 | Akzo Nobel Nv | Salmonella impfstoff, der keinen antikörper gegen flagellin oder gegen flagella induziert |
| US7371392B2 (en) | 2000-02-02 | 2008-05-13 | The United States Of America As Represented By The Department Of Health And Human Services | Cd40 ligand adjuvant for respiratory syncytial virus |
| ATE300949T1 (de) | 2000-03-17 | 2005-08-15 | Pharmacia & Upjohn Co Llc | Ssa inaktivierte salmonella impfstoffe |
| GB0015426D0 (en) | 2000-06-24 | 2000-08-16 | Univ Southampton | Method for generating soluble highly multimeric proteins |
| AU2002221780A1 (en) | 2000-10-31 | 2002-05-15 | F.Hoffmann-La Roche Ag | Nucleic acids encoding cd40/cd40l chimeric polypeptides, methods for their production and uses thereof |
| US8703146B2 (en) | 2001-04-20 | 2014-04-22 | Institute For Systems Biology | Toll-like receptor 5 ligands and methods of use |
| ES2329453T3 (es) | 2001-05-15 | 2009-11-26 | Ortho Mcneil Janssen Pharm | Cebado ex-vivo para generar linfocitos t citotoxicos especificos del ligando cd40 para tratar enfermedades autoinmunitarias y alergicas. |
| US6923958B2 (en) | 2002-03-02 | 2005-08-02 | The Scripps Research Institute | DNA vaccines encoding CEA and a CD40 ligand and methods of use thereof |
| WO2003096812A1 (en) * | 2002-04-15 | 2003-11-27 | Washington University | Regulated attenuation of live vaccines to enhance cross protective immunogenicity |
| US7495090B2 (en) | 2002-05-23 | 2009-02-24 | The Regents Of The University Of California | Nucleic acids encoding chimeric CD154 polypeptides |
| US20060014248A1 (en) | 2003-01-06 | 2006-01-19 | Xencor, Inc. | TNF super family members with altered immunogenicity |
| US20050181994A1 (en) | 2003-01-06 | 2005-08-18 | Xencor, Inc. | Novel variants of CD40L protein |
| US7754209B2 (en) * | 2003-07-26 | 2010-07-13 | Trubion Pharmaceuticals | Binding constructs and methods for use thereof |
| WO2005035570A2 (en) | 2003-10-10 | 2005-04-21 | Xencor, Inc. | Variants of cd40l protein |
| US8828957B2 (en) | 2003-12-11 | 2014-09-09 | Microvax, Llc | Methods for generating immunity to antigen |
| CA2548347A1 (en) | 2003-12-11 | 2005-06-30 | Sidney Kimmel Cancer Center | Methods for generating immunity to antigen |
| US7098058B1 (en) * | 2004-01-15 | 2006-08-29 | University Of Toledo | Photovoltaic healing of non-uniformities in semiconductor devices |
| EP1740604A2 (en) | 2004-04-27 | 2007-01-10 | Intercell AG | Td antigens |
| WO2005113598A2 (en) | 2004-05-21 | 2005-12-01 | Xencor, Inc. | Tnf super family members with altered immunogenicity |
| US20060249202A1 (en) * | 2004-09-20 | 2006-11-09 | Seunghyup Yoo | Photovoltaic cell |
| US8513008B2 (en) | 2004-10-07 | 2013-08-20 | Argos Therapeutics, Inc. | Mature dendritic cell compositions and methods for culturing same |
| TWI382843B (zh) | 2004-10-07 | 2013-01-21 | Argos Therapeutics Inc | 成熟樹突細胞組合物及培養彼等之方法 |
| WO2006105972A1 (en) | 2005-04-07 | 2006-10-12 | Universite Libre De Bruxelles | Transgenic organism expressing cd40l and uses thereof |
| US20060286074A1 (en) | 2005-05-31 | 2006-12-21 | Yucheng Tang | Methods for immunotherapy of cancer |
| RS51402B (sr) | 2005-10-07 | 2011-02-28 | Proyecto De Biomedicina Cima, S.L. | Imunostimulatorne kombinacije za profilaksu i lečenje hepatitisa c |
| JP2009514536A (ja) | 2005-11-07 | 2009-04-09 | シドニー キンメル キャンサー センター | Ｃｄ４０リガンド融合蛋白質ワクチン |
| WO2007054658A1 (en) | 2005-11-14 | 2007-05-18 | King's College London | Control of immune responses |
| WO2007103048A2 (en) | 2006-03-01 | 2007-09-13 | Regents Of The University Of Colorado | Tlr agonist (flagellin)/cd40 agonist/antigen protein and dna conjugates and use thereof for inducing synergistic enhancement in immunity |
| WO2007106073A2 (en) | 2006-03-02 | 2007-09-20 | University Of Massachusetts | Modified pathogens for use as vaccines |
| US20070227586A1 (en) * | 2006-03-31 | 2007-10-04 | Kla-Tencor Technologies Corporation | Detection and ablation of localized shunting defects in photovoltaics |
| EP2857038B1 (en) | 2006-09-18 | 2019-04-10 | The Board of Trustees of the University of Arkansas | Compositions and methods of enhancing immune responses |
| WO2008109825A2 (en) | 2007-03-08 | 2008-09-12 | Mayo Foundation For Medical Education And Research | Inducing immune-mediated tumor cell death |
| PT2214701T (pt) | 2007-11-01 | 2016-11-02 | Univ Guelph | Composições e métodos de potenciar respostas imunes a eimeria |
-
2008
- 2008-10-30 CA CA 2704457 patent/CA2704457A1/en not_active Abandoned
- 2008-10-30 EP EP20080832781 patent/EP2214840B1/en active Active
- 2008-10-30 CN CN2008801169113A patent/CN102037135A/zh active Pending
- 2008-10-30 WO PCT/US2008/081813 patent/WO2009059018A1/en not_active Ceased
- 2008-10-30 BR BRPI0818736A patent/BRPI0818736A2/pt not_active IP Right Cessation
- 2008-10-30 US US12/740,631 patent/US9125854B2/en active Active
- 2008-10-30 JP JP2010532246A patent/JP2011502165A/ja active Pending
- 2008-10-30 AU AU2008318615A patent/AU2008318615A1/en not_active Abandoned
- 2008-10-30 NZ NZ585776A patent/NZ585776A/en not_active IP Right Cessation
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