JP2011256183A5 - - Google Patents
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- Publication number
- JP2011256183A5 JP2011256183A5 JP2011164086A JP2011164086A JP2011256183A5 JP 2011256183 A5 JP2011256183 A5 JP 2011256183A5 JP 2011164086 A JP2011164086 A JP 2011164086A JP 2011164086 A JP2011164086 A JP 2011164086A JP 2011256183 A5 JP2011256183 A5 JP 2011256183A5
- Authority
- JP
- Japan
- Prior art keywords
- neuropilin
- nrp1
- nrp
- inhibiting
- biological activity
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 102000002111 Neuropilin Human genes 0.000 claims 2
- 108050009450 Neuropilin Proteins 0.000 claims 2
- 102000004207 Neuropilin-1 Human genes 0.000 claims 1
- 108090000772 Neuropilin-1 Proteins 0.000 claims 1
- 230000004071 biological effect Effects 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 230000001404 mediated effect Effects 0.000 claims 1
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US73479805P | 2005-11-08 | 2005-11-08 | |
| US60/734,798 | 2005-11-08 | ||
| US82056106P | 2006-07-27 | 2006-07-27 | |
| US60/820,561 | 2006-07-27 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008540169A Division JP5197376B2 (ja) | 2005-11-08 | 2006-11-08 | ニューロピリンアンタゴニスト |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2011256183A JP2011256183A (ja) | 2011-12-22 |
| JP2011256183A5 true JP2011256183A5 (https=) | 2012-10-04 |
Family
ID=38023965
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008540169A Expired - Fee Related JP5197376B2 (ja) | 2005-11-08 | 2006-11-08 | ニューロピリンアンタゴニスト |
| JP2011164086A Pending JP2011256183A (ja) | 2005-11-08 | 2011-07-27 | ニューロピリンアンタゴニスト |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008540169A Expired - Fee Related JP5197376B2 (ja) | 2005-11-08 | 2006-11-08 | ニューロピリンアンタゴニスト |
Country Status (20)
| Country | Link |
|---|---|
| US (5) | US7994286B2 (https=) |
| EP (2) | EP1951758A2 (https=) |
| JP (2) | JP5197376B2 (https=) |
| KR (1) | KR101096359B1 (https=) |
| CN (2) | CN101326196B (https=) |
| AU (1) | AU2006311590B2 (https=) |
| BR (1) | BRPI0619688A2 (https=) |
| CA (2) | CA2892180A1 (https=) |
| CR (2) | CR10017A (https=) |
| EC (1) | ECSP088508A (https=) |
| IL (2) | IL190960A (https=) |
| MA (1) | MA29975B1 (https=) |
| MY (1) | MY154904A (https=) |
| NO (1) | NO20082531L (https=) |
| NZ (2) | NZ567514A (https=) |
| RU (1) | RU2425842C2 (https=) |
| SG (1) | SG173408A1 (https=) |
| UA (2) | UA96139C2 (https=) |
| WO (1) | WO2007056470A2 (https=) |
| ZA (2) | ZA200803811B (https=) |
Families Citing this family (85)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL212317B1 (pl) * | 2003-01-31 | 2012-09-28 | Organon Nv | Sposób izolacji bialka zawierajacego wiazania disulfidowe w natywnej konformacji |
| EP1957531B1 (en) * | 2005-11-07 | 2016-04-13 | Genentech, Inc. | Binding polypeptides with diversified and consensus vh/vl hypervariable sequences |
| UA96139C2 (uk) * | 2005-11-08 | 2011-10-10 | Дженентек, Інк. | Антитіло до нейропіліну-1 (nrp1) |
| CA2822302A1 (en) | 2006-02-13 | 2007-08-23 | Alethia Biotherapeutics Inc. | Methods of impairing osteoclast differentiation |
| US8168181B2 (en) | 2006-02-13 | 2012-05-01 | Alethia Biotherapeutics, Inc. | Methods of impairing osteoclast differentiation using antibodies that bind siglec-15 |
| CA2655933C (en) * | 2006-06-23 | 2014-09-09 | Alethia Biotherapeutics Inc. | Polynucleotides and polypeptide sequences involved in cancer |
| US8648173B2 (en) | 2007-05-17 | 2014-02-11 | Genentech, Inc. | Inhibition of tumor metastasis by anti neuropilin 2 antibodies |
| EP3050566B1 (en) * | 2007-09-10 | 2018-11-28 | Boston Biomedical, Inc. | A novel group of stat3 pathway inhibitors and cancer stem cell pathway inhibitors |
| US9808506B2 (en) | 2007-10-19 | 2017-11-07 | Rappaport Family Institute For Research In The Medical Sciences | Compositions comprising semaphorins for the treatment of cancer and methods of selection thereof |
| EP2210092B1 (en) * | 2007-10-19 | 2014-06-11 | Rappaport Family Institute for Research in the Medical Sciences | Compositions comprising semaphorins for the treatment of angiogenesis related diseases and methods of selection thereof |
| TWI580694B (zh) | 2007-11-30 | 2017-05-01 | 建南德克公司 | 抗-vegf抗體 |
| BRPI0910482A2 (pt) | 2008-04-29 | 2019-09-24 | Abbott Lab | imunoglobinas de domínio variável duplo e usos das mesmas |
| UY31800A (es) * | 2008-05-05 | 2009-11-10 | Smithkline Beckman Corp | Metodo de tratamiento de cancer usando un inhibidor de cmet y axl y un inhibidor de erbb |
| SG10201608871XA (en) | 2008-05-05 | 2016-12-29 | Novimmune Sa | Anti-il-17a/il-17f cross-reactive antibodies and methods of use thereof |
| PE20100092A1 (es) | 2008-06-03 | 2010-03-12 | Abbott Lab | Inmunoglobulina con dominio variable dual y usos de la misma |
| BRPI0913366A8 (pt) | 2008-06-03 | 2017-07-11 | Abbott Lab | Imunoglobulinas de domínio variável duplo e seus usos |
| NZ603698A (en) | 2008-07-08 | 2014-03-28 | Abbvie Inc | Prostaglandin e2 dual variable domain immunoglobulins and uses thereof |
| US8790642B2 (en) | 2008-08-29 | 2014-07-29 | Genentech, Inc. | Cross-reactive and bispecific anti-IL-17A/F antibodies |
| KR20110084280A (ko) | 2008-11-03 | 2011-07-21 | 알레시아 바이오쎄라퓨틱스 인코포레이티드 | 종양 항원의 생물 활성을 특이적으로 차단하는 항체 |
| EP2350264A4 (en) * | 2008-11-06 | 2012-08-29 | Univ Johns Hopkins | TREATMENT OF CHRONIC INFLAMMATION OF THE RESPIRATORY TRACT |
| CA2759848C (en) | 2009-05-05 | 2018-12-04 | Novimmune S.A. | Anti-il-17f antibodies and methods of use thereof |
| CA2767616A1 (en) | 2009-07-09 | 2011-01-13 | The Scripps Research Institute | Gene expression profiles associated with chronic allograft nephropathy |
| CN102482715A (zh) * | 2009-07-13 | 2012-05-30 | 霍夫曼-拉罗奇有限公司 | 用于癌症治疗的诊断方法和组合物 |
| KR20120060877A (ko) | 2009-09-01 | 2012-06-12 | 아보트 러보러터리즈 | 이원 가변 도메인 면역글로불린 및 이의 용도 |
| AU2010306677B2 (en) | 2009-10-15 | 2013-05-23 | Abbvie Inc. | Dual variable domain immunoglobulins and uses thereof |
| UY32979A (es) | 2009-10-28 | 2011-02-28 | Abbott Lab | Inmunoglobulinas con dominio variable dual y usos de las mismas |
| EP2497498A4 (en) * | 2009-11-05 | 2013-04-17 | Univ Osaka | THERAPEUTIC ACTIVE FOR AUTOIMMUNE DISEASES OR ALLERGIES AND METHOD FOR SCREENING AFTER THE THERAPEUTIC ACTIVE SUBSTANCE |
| JP5818805B2 (ja) | 2009-12-11 | 2015-11-18 | ジェネンテック, インコーポレイテッド | 抗vegf−c抗体及びその使用方法 |
| ES2594893T3 (es) | 2009-12-16 | 2016-12-23 | Abbvie Biotherapeutics Inc. | Anticuerpos anti HER2 y sus usos |
| WO2011143408A1 (en) * | 2010-05-13 | 2011-11-17 | Genentech, Inc. | Use of neuropilin-1 antagonists for the treatment of cancer |
| WO2011153224A2 (en) | 2010-06-02 | 2011-12-08 | Genentech, Inc. | Diagnostic methods and compositions for treatment of cancer |
| BR112012027995A2 (pt) | 2010-06-18 | 2017-01-10 | Genentech Inc | anticorpo e ácido nucleíco isolado, célula hospedeira, método de produção de um anticorpo, imunoconjugado, formulação farmacêutica, uso do anticorpo, método de tratamento de um indivíduo com câncer, de um indivíduo possuíndo um distúrbio imune, de inibição da angiogênese e para inibir a ativação constitutiva de axl |
| KR20120003187A (ko) * | 2010-07-02 | 2012-01-10 | 한국생명공학연구원 | Neuropilin 1 유전자를 이용한 천식 진단 및 천식 치료제 스크리닝 방법 |
| WO2012006503A1 (en) * | 2010-07-09 | 2012-01-12 | Genentech, Inc. | Anti-neuropilin antibodies and methods of use |
| US8735546B2 (en) | 2010-08-03 | 2014-05-27 | Abbvie Inc. | Dual variable domain immunoglobulins and uses thereof |
| PE20140229A1 (es) | 2010-08-26 | 2014-03-27 | Abbvie Inc | Inmunoglobulinas con dominio variable dual y usos de las mismas |
| MX346500B (es) | 2010-11-10 | 2017-03-22 | Genentech Inc * | Metodos y composiciones para inmunoterapia para enfermedad neural. |
| RS59080B1 (sr) | 2011-03-31 | 2019-09-30 | Adc Therapeutics Sa | Antitela protiv antigena 1 povezanog sa bubrezima i njihovi fragmenti koji se vezuju za antigen |
| EP2522341A1 (en) | 2011-05-13 | 2012-11-14 | Tragex Pharma | Pharmaceutical compositions comprising Neuropilin inhibitors, and their use for the prevention and/or treatment of angiogenic disorders and cancers |
| AU2012335543C1 (en) | 2011-11-09 | 2017-12-14 | Beijing Cotimes Biotech Co., Ltd., | HER3 antibodies and uses thereof |
| AR089529A1 (es) | 2011-12-30 | 2014-08-27 | Abbvie Inc | Proteinas de union especificas duales dirigidas contra il-13 y/o il-17 |
| HRP20190946T1 (hr) | 2012-01-09 | 2019-07-26 | Adc Therapeutics Sa | Sredstva za liječenje trostruko negativnog raka dojke |
| AU2013271581B2 (en) * | 2012-06-08 | 2018-08-09 | Janssen Biotech, Inc. | Differentiation of human embryonic stem cells into pancreatic endocrine cells |
| US9493562B2 (en) | 2012-07-19 | 2016-11-15 | Alethia Biotherapeutics Inc. | Anti-Siglec-15 antibodies |
| AU2013329372B2 (en) * | 2012-10-08 | 2018-07-12 | St. Jude Children's Research Hospital | Therapies based on control of regulatory T cell stability and function via a Neuropilin-1:Semaphorin axis |
| KR20180008921A (ko) | 2012-11-01 | 2018-01-24 | 애브비 인코포레이티드 | 항-vegf/dll4 이원 가변 도메인 면역글로불린 및 이의 용도 |
| CN105324396A (zh) | 2013-03-15 | 2016-02-10 | 艾伯维公司 | 针对IL-1β和/或IL-17的双重特异性结合蛋白 |
| EP2983790A2 (en) | 2013-04-09 | 2016-02-17 | Boston Biomedical, Inc. | Methods for treating cancer |
| ITMI20131351A1 (it) * | 2013-08-07 | 2015-02-08 | Biouniversa Srl | Molecole leganti il recettore di bag3 per uso terapeutico. |
| ES2831014T3 (es) * | 2014-02-18 | 2021-06-07 | Inst Nat Sante Rech Med | Métodos y composiciones farmacéuticas para el tratamiento de enfermedades mediadas por la vía de señalización del complejo NRP-1/OBR |
| US11104951B2 (en) | 2014-05-22 | 2021-08-31 | The Scripps Research Institute | Molecular signatures for distinguishing liver transplant rejections or injuries |
| US10443100B2 (en) | 2014-05-22 | 2019-10-15 | The Scripps Research Institute | Gene expression profiles associated with sub-clinical kidney transplant rejection |
| JP6692816B2 (ja) * | 2014-09-05 | 2020-05-13 | アールエスイーエム,リミティド パートナーシップ | 炎症を処置および予防するための組成物および方法 |
| EP3221361B1 (en) | 2014-11-19 | 2021-04-21 | Genentech, Inc. | Anti-transferrin receptor / anti-bace1 multispecific antibodies and methods of use |
| WO2016081639A1 (en) | 2014-11-19 | 2016-05-26 | Genentech, Inc. | Antibodies against bace1 and use thereof for neural disease immunotherapy |
| CN107108743B (zh) * | 2014-12-03 | 2021-05-04 | (株)爱恩德生物 | 结合神经毡蛋白1的抗体及其用途 |
| WO2016094881A2 (en) | 2014-12-11 | 2016-06-16 | Abbvie Inc. | Lrp-8 binding proteins |
| TW201710286A (zh) | 2015-06-15 | 2017-03-16 | 艾伯維有限公司 | 抗vegf、pdgf及/或其受體之結合蛋白 |
| JP6924708B2 (ja) | 2015-06-29 | 2021-08-25 | ザ・ユニバーシティ・オブ・ブリティッシュ・コロンビア | B1sp融合タンパク質の治療薬、方法、および使用 |
| US10688178B2 (en) | 2015-06-30 | 2020-06-23 | Osaka University | AntiPlexin A1 agonist antibody |
| WO2017119434A1 (ja) * | 2016-01-06 | 2017-07-13 | 株式会社オーダーメードメディカルリサーチ | Vegfとnrp1との結合を阻害する抗体 |
| WO2017119435A1 (ja) | 2016-01-06 | 2017-07-13 | 株式会社オーダーメードメディカルリサーチ | 高親和性抗vegf抗体 |
| KR101985299B1 (ko) | 2016-06-03 | 2019-09-03 | 삼성전자주식회사 | 항-c-Met/항-Nrp1 이중 특이 항체 |
| WO2017209554A2 (ko) * | 2016-06-03 | 2017-12-07 | 사회복지법인 삼성생명공익재단 | 항-nrp1 항체 스크리닝 방법 |
| WO2017209553A2 (ko) * | 2016-06-03 | 2017-12-07 | 사회복지법인 삼성생명공익재단 | 환자 유래 세포를 이용한 항체 스크리닝 방법 |
| US11085930B2 (en) | 2016-06-03 | 2021-08-10 | Aimed Bio Inc. | Anti-NRP1 antibody screening method |
| CA3026236C (en) | 2016-06-03 | 2021-01-26 | Samsung Life Public Welfare Foundation | Method for screening antibody using patient-derived tumor spheroids |
| JP7106563B2 (ja) | 2016-11-29 | 2022-07-26 | スミトモ ファーマ オンコロジー, インコーポレイテッド | ナフトフラン誘導体、その調製、および使用方法 |
| JOP20190134A1 (ar) * | 2016-12-23 | 2019-06-02 | Potenza Therapeutics Inc | بروتينات رابطة لمولد ضد مضادة لنيوروبيلين وطرق استخدامها |
| CA3062656A1 (en) | 2017-05-17 | 2018-11-22 | Boston Biomedical, Inc. | Methods for treating cancer |
| CN108196071A (zh) * | 2018-02-09 | 2018-06-22 | 上海市第十人民医院 | 肝癌血清标志物nrp1 |
| EP3758751A4 (en) | 2018-02-28 | 2021-11-17 | Wuxi Biologics Ireland Limited. | MONOCLONAL ANTIBODIES AGAINST HUMAN LAG-3, METHOD OF MANUFACTURING AND USING THEREOF |
| CA3096222A1 (en) | 2018-04-06 | 2019-10-10 | Atyr Pharma, Inc. | Compositions and methods comprising anti-nrp2 antibodies |
| EP3906415B1 (en) * | 2019-01-03 | 2026-04-15 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and pharmaceutical compositions for enhancing cd8+ t cell-dependent immune responses in subjects suffering from cancer |
| CN109883932B (zh) * | 2019-02-18 | 2021-08-10 | 武汉伊莱瑞特生物科技股份有限公司 | 流式抗体及其制备方法和滴定方法 |
| TWI859339B (zh) * | 2019-09-24 | 2024-10-21 | 德商百靈佳殷格翰國際股份有限公司 | 抗nrp1a抗體及其用於治療眼或眼部疾病之用途 |
| CN114746120B (zh) * | 2019-10-03 | 2024-07-30 | Atyr医药公司 | 包含抗nrp2抗体的组合物和方法 |
| WO2021138391A1 (en) | 2019-12-30 | 2021-07-08 | Tyra Biosciences, Inc. | Indazole compounds |
| JP2023539428A (ja) * | 2020-07-31 | 2023-09-14 | パイントゥリー セラピューティックス インコーポレイテッド | ウイルス感染症を処置するためのニューロピリンおよびアンジオテンシン変換酵素2融合ペプチド |
| WO2022117572A2 (en) | 2020-12-02 | 2022-06-09 | Oncurious Nv | An ltbr agonist in combination therapy against cancer |
| CN119403831A (zh) * | 2022-03-30 | 2025-02-07 | 松树治疗公司 | 包含nrp1结合结构域的双特异性抗体及其使用方法 |
| CA3263050A1 (en) * | 2022-07-30 | 2024-02-08 | Pinetree Therapeutics, Inc. | Compositions for targeted lysosomal degradation and their methods of use |
| EP4403578A1 (en) * | 2023-01-19 | 2024-07-24 | Theranovir | Antibody aginst a glycosaminoglycan-modified neuropilin-1 epitope and methods of use thereof |
| EP4652196A1 (en) * | 2023-01-19 | 2025-11-26 | Theranovir | Neuropilin-1-peptide based antibody, highliting new epitope associated to glycosaminoglycan-modified neuropilin-1 and methods of use thereof |
| CN117164711B (zh) * | 2023-09-28 | 2024-01-30 | 北京凯祥弘康生物科技有限公司 | 一种抗神经纤维丝轻链蛋白的抗体 |
Family Cites Families (66)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US550362A (en) * | 1895-11-26 | crosby | ||
| US3773919A (en) | 1969-10-23 | 1973-11-20 | Du Pont | Polylactide-drug mixtures |
| USRE30985E (en) | 1978-01-01 | 1982-06-29 | Serum-free cell culture media | |
| US4275149A (en) | 1978-11-24 | 1981-06-23 | Syva Company | Macromolecular environment control in specific receptor assays |
| US4318980A (en) | 1978-04-10 | 1982-03-09 | Miles Laboratories, Inc. | Heterogenous specific binding assay employing a cycling reactant as label |
| US4376110A (en) | 1980-08-04 | 1983-03-08 | Hybritech, Incorporated | Immunometric assays using monoclonal antibodies |
| US4419446A (en) | 1980-12-31 | 1983-12-06 | The United States Of America As Represented By The Department Of Health And Human Services | Recombinant DNA process utilizing a papilloma virus DNA as a vector |
| NZ201705A (en) | 1981-08-31 | 1986-03-14 | Genentech Inc | Recombinant dna method for production of hepatitis b surface antigen in yeast |
| US4601978A (en) | 1982-11-24 | 1986-07-22 | The Regents Of The University Of California | Mammalian metallothionein promoter system |
| US4560655A (en) | 1982-12-16 | 1985-12-24 | Immunex Corporation | Serum-free cell culture medium and process for making same |
| US4657866A (en) | 1982-12-21 | 1987-04-14 | Sudhir Kumar | Serum-free, synthetic, completely chemically defined tissue culture media |
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| US4675187A (en) | 1983-05-16 | 1987-06-23 | Bristol-Myers Company | BBM-1675, a new antibiotic complex |
| DD266710A3 (de) | 1983-06-06 | 1989-04-12 | Ve Forschungszentrum Biotechnologie | Verfahren zur biotechnischen Herstellung van alkalischer Phosphatase |
| US4767704A (en) | 1983-10-07 | 1988-08-30 | Columbia University In The City Of New York | Protein-free culture medium |
| US4965199A (en) | 1984-04-20 | 1990-10-23 | Genentech, Inc. | Preparation of functional human factor VIII in mammalian cells using methotrexate based selection |
| US4879231A (en) | 1984-10-30 | 1989-11-07 | Phillips Petroleum Company | Transformation of yeasts of the genus pichia |
| US4737456A (en) | 1985-05-09 | 1988-04-12 | Syntex (U.S.A.) Inc. | Reducing interference in ligand-receptor binding assays |
| GB8516415D0 (en) | 1985-06-28 | 1985-07-31 | Celltech Ltd | Culture of animal cells |
| GB8607679D0 (en) | 1986-03-27 | 1986-04-30 | Winter G P | Recombinant dna product |
| US4927762A (en) | 1986-04-01 | 1990-05-22 | Cell Enterprises, Inc. | Cell culture medium with antioxidant |
| GB8610600D0 (en) | 1986-04-30 | 1986-06-04 | Novo Industri As | Transformation of trichoderma |
| IL85035A0 (en) | 1987-01-08 | 1988-06-30 | Int Genetic Eng | Polynucleotide molecule,a chimeric antibody with specificity for human b cell surface antigen,a process for the preparation and methods utilizing the same |
| WO1989006692A1 (en) | 1988-01-12 | 1989-07-27 | Genentech, Inc. | Method of treating tumor cells by inhibiting growth factor receptor function |
| AU632065B2 (en) | 1988-09-23 | 1992-12-17 | Novartis Vaccines And Diagnostics, Inc. | Cell culture medium for enhanced cell growth, culture longevity and product expression |
| EP0368684B2 (en) | 1988-11-11 | 2004-09-29 | Medical Research Council | Cloning immunoglobulin variable domain sequences. |
| FR2646437B1 (fr) | 1989-04-28 | 1991-08-30 | Transgene Sa | Nouvelles sequences d'adn, leur application en tant que sequence codant pour un peptide signal pour la secretion de proteines matures par des levures recombinantes, cassettes d'expression, levures transformees et procede de preparation de proteines correspondant |
| EP0402226A1 (en) | 1989-06-06 | 1990-12-12 | Institut National De La Recherche Agronomique | Transformation vectors for yeast yarrowia |
| DE3920358A1 (de) | 1989-06-22 | 1991-01-17 | Behringwerke Ag | Bispezifische und oligospezifische, mono- und oligovalente antikoerperkonstrukte, ihre herstellung und verwendung |
| US5427908A (en) | 1990-05-01 | 1995-06-27 | Affymax Technologies N.V. | Recombinant library screening methods |
| US5723286A (en) | 1990-06-20 | 1998-03-03 | Affymax Technologies N.V. | Peptide library and screening systems |
| GB9015198D0 (en) | 1990-07-10 | 1990-08-29 | Brien Caroline J O | Binding substance |
| US6172197B1 (en) | 1991-07-10 | 2001-01-09 | Medical Research Council | Methods for producing members of specific binding pairs |
| US5122469A (en) | 1990-10-03 | 1992-06-16 | Genentech, Inc. | Method for culturing Chinese hamster ovary cells to improve production of recombinant proteins |
| CA2405246A1 (en) | 1990-12-03 | 1992-06-11 | Genentech, Inc. | Enrichment method for variant proteins with alterred binding properties |
| DK0580737T3 (da) | 1991-04-10 | 2004-11-01 | Scripps Research Inst | Heterodimere receptorbiblioteker ved anvendelse af phagemider |
| US5270170A (en) | 1991-10-16 | 1993-12-14 | Affymax Technologies N.V. | Peptide library and screening method |
| DE69232137T2 (de) | 1991-11-25 | 2002-05-29 | Enzon Inc | Multivalente antigen-bindende proteine |
| US5733743A (en) | 1992-03-24 | 1998-03-31 | Cambridge Antibody Technology Limited | Methods for producing members of specific binding pairs |
| US5521184A (en) | 1992-04-03 | 1996-05-28 | Ciba-Geigy Corporation | Pyrimidine derivatives and processes for the preparation thereof |
| TW225528B (https=) | 1992-04-03 | 1994-06-21 | Ciba Geigy Ag | |
| MD1367C2 (ro) | 1992-11-13 | 2000-11-30 | Idec Pharmaceuticals Corporation | Metode de tratament al limfomului celulelor B, anticorpi anti-CD20, hibridom. |
| CN1701814A (zh) | 1992-11-13 | 2005-11-30 | 马克斯普朗克科学促进协会 | 作为血管内皮生长因子受体的f1k-1 |
| ATE199392T1 (de) | 1992-12-04 | 2001-03-15 | Medical Res Council | Multivalente und multispezifische bindungsproteine, deren herstellung und verwendung |
| US5635388A (en) | 1994-04-04 | 1997-06-03 | Genentech, Inc. | Agonist antibodies against the flk2/flt3 receptor and uses thereof |
| GB9410534D0 (en) | 1994-05-26 | 1994-07-13 | Lynxvale Ltd | Improvements in or relating to growth factor inhibitors |
| IL117645A (en) | 1995-03-30 | 2005-08-31 | Genentech Inc | Vascular endothelial cell growth factor antagonists for use as medicaments in the treatment of age-related macular degeneration |
| US5874562A (en) | 1995-06-07 | 1999-02-23 | Progenitor, Inc. | Nucleic acid encoding developmentally-regulated endothelial cell locus-1 |
| US6020473A (en) | 1995-08-25 | 2000-02-01 | Genentech, Inc. | Nucleic acids encoding variants of vascular endothelial cell growth factor |
| CO4950519A1 (es) | 1997-02-13 | 2000-09-01 | Novartis Ag | Ftalazinas, preparaciones farmaceuticas que las comprenden y proceso para su preparacion |
| JP3957765B2 (ja) | 1997-04-07 | 2007-08-15 | ジェネンテク・インコーポレイテッド | 抗vegf抗体 |
| EP2338915A3 (en) | 1997-04-07 | 2011-10-12 | Genentech, Inc. | Anti-VEGF antibodies |
| ES2292204T3 (es) * | 1997-06-18 | 2008-03-01 | MERCK & CO., INC. (A NEW JERSEY CORP.) | Receptor de tipo tirosina cinasa humano, kdr. |
| EP0892047A3 (de) * | 1997-07-09 | 2000-03-08 | Hoechst Marion Roussel Deutschland GmbH | Humanes und murines Semaphorin L |
| US6777534B1 (en) * | 1997-12-09 | 2004-08-17 | Children's Medical Center Corporation | Peptide antagonists of vascular endothelial growth factor |
| AU1810899A (en) | 1997-12-09 | 1999-06-28 | Children's Medical Center Corporation | Neuropilins and use thereof in methods for diagnosis and prognosis of cancer |
| CA2313607A1 (en) * | 1997-12-09 | 1999-06-17 | Children's Medical Center Corporation | Antagonists of neuropilin receptor function and use thereof |
| WO1999029858A1 (en) | 1997-12-09 | 1999-06-17 | Children's Medical Center Corporation | Soluble inhibitors of vascular endothelial growth factor and use thereof |
| RS49779B (sr) | 1998-01-12 | 2008-06-05 | Glaxo Group Limited, | Biciklična heteroaromatična jedinjenja kao inhibitori protein tirozin kinaze |
| SI1255752T1 (sl) | 2000-02-15 | 2007-12-31 | Pharmacia & Upjohn Co Llc | S pirolom substituirani zaviralci 2-indolinon protein kinaza |
| EP1513879B1 (en) | 2002-06-03 | 2018-08-22 | Genentech, Inc. | Synthetic antibody phage libraries |
| EP1439192A1 (en) * | 2003-01-15 | 2004-07-21 | Xerion Pharmaceuticals AG | Neuropilin-1 inhibitors |
| US6956123B2 (en) * | 2003-03-17 | 2005-10-18 | Natural Pharmaccuticals, Inc. | Purification of taxanes and taxane mixtures using polyethyleneimine-bonded resins |
| MXPA06004853A (es) * | 2003-11-07 | 2006-07-06 | Immunex Corp | Anticuerpos que se aglutinan al receptor 4 de interleucina. |
| US7563443B2 (en) * | 2004-09-17 | 2009-07-21 | Domantis Limited | Monovalent anti-CD40L antibody polypeptides and compositions thereof |
| UA96139C2 (uk) * | 2005-11-08 | 2011-10-10 | Дженентек, Інк. | Антитіло до нейропіліну-1 (nrp1) |
-
2006
- 2006-08-11 UA UAA200807262A patent/UA96139C2/uk unknown
- 2006-11-08 RU RU2008122710/10A patent/RU2425842C2/ru not_active IP Right Cessation
- 2006-11-08 KR KR1020087013575A patent/KR101096359B1/ko not_active Expired - Fee Related
- 2006-11-08 WO PCT/US2006/043516 patent/WO2007056470A2/en not_active Ceased
- 2006-11-08 AU AU2006311590A patent/AU2006311590B2/en not_active Ceased
- 2006-11-08 EP EP06827637A patent/EP1951758A2/en not_active Withdrawn
- 2006-11-08 JP JP2008540169A patent/JP5197376B2/ja not_active Expired - Fee Related
- 2006-11-08 MY MYPI20081300A patent/MY154904A/en unknown
- 2006-11-08 NZ NZ567514A patent/NZ567514A/en not_active IP Right Cessation
- 2006-11-08 CA CA2892180A patent/CA2892180A1/en not_active Abandoned
- 2006-11-08 BR BRPI0619688-8A patent/BRPI0619688A2/pt not_active IP Right Cessation
- 2006-11-08 ZA ZA200803811A patent/ZA200803811B/xx unknown
- 2006-11-08 CN CN200680045839.0A patent/CN101326196B/zh not_active Expired - Fee Related
- 2006-11-08 UA UAA201106573A patent/UA98585C2/uk unknown
- 2006-11-08 CN CN2011102068626A patent/CN102304184A/zh active Pending
- 2006-11-08 SG SG2011053212A patent/SG173408A1/en unknown
- 2006-11-08 CA CA002629028A patent/CA2629028A1/en not_active Abandoned
- 2006-11-08 NZ NZ593289A patent/NZ593289A/xx not_active IP Right Cessation
- 2006-11-08 EP EP12180518.8A patent/EP2570434A3/en not_active Withdrawn
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2008
- 2008-04-17 IL IL190960A patent/IL190960A/en not_active IP Right Cessation
- 2008-04-22 US US12/107,544 patent/US7994286B2/en not_active Expired - Fee Related
- 2008-05-23 CR CR10017A patent/CR10017A/es unknown
- 2008-05-30 MA MA30971A patent/MA29975B1/fr unknown
- 2008-06-06 NO NO20082531A patent/NO20082531L/no not_active Application Discontinuation
- 2008-06-06 EC EC2008008508A patent/ECSP088508A/es unknown
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2009
- 2009-05-28 ZA ZA2009/03718A patent/ZA200903718B/en unknown
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2011
- 2011-06-30 US US13/173,890 patent/US8211429B2/en not_active Expired - Fee Related
- 2011-07-27 JP JP2011164086A patent/JP2011256183A/ja active Pending
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2012
- 2012-06-05 US US13/489,299 patent/US8378080B2/en not_active Expired - Fee Related
- 2012-11-08 IL IL222922A patent/IL222922A/en not_active IP Right Cessation
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2013
- 2013-01-11 US US13/740,080 patent/US8795660B2/en active Active
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2014
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2015
- 2015-02-06 US US14/616,415 patent/US20160304613A1/en not_active Abandoned
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