JP2011152425A - 膨張可能な多孔性インプラント、及び薬物送達のための方法 - Google Patents
膨張可能な多孔性インプラント、及び薬物送達のための方法 Download PDFInfo
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Abstract
【解決手段】グラフト及びステントグラフト10は、身体の流路内に治療薬及び/又は診断薬を送達する。膨張可能な多孔性インプラントは、薬物をより多量に、且つより正確な投与量で、より長い投与時間に亘って身体内に直接送達する。さらにこれら膨張可能な多孔性インプラントは、多くの場合、挿入時に柔軟であり、留置が容易なように小型の送達形態を有する。本発明のインプラントは、さらに、一体化された単一構造にて、薬物送達に加えて機械的又は構造的機能を提供し得る。
【選択図】図1
Description
Claims (35)
- 近位端及び遠位端を有し、且つ少なくとも一個の膨張可能な多孔性チャネルを画成するグラフト本体部と、
前記膨張可能なチャネル内に導入されるように構成された、少なくとも一種の治療薬を含有する膨張媒体と、
を備えるグラフト。 - 前記治療薬は、前記膨張媒体から前記多孔性チャネルの壁を介して輸送されて、身体の管腔内に放出されることが可能である、請求項1に記載のグラフト。
- 前記治療薬は、前記グラフト本体部の管腔側及び反管腔側のいずれか一方から身体の管腔内に放出されるように構成されている、請求項2に記載のグラフト。
- 前記多孔性チャネルは様々な多孔度を有する、請求項2に記載のグラフト。
- 前記グラフト本体部は、フルオロポリマー、ポリエチレンテレフタレート、ポリ塩化ビニル、ポリウレタン、ポリオレフィン、及びポリアミドからなる群から選択された一種又は二種以上の材料を含む、請求項2に記載のグラフト。
- 前記グラフト本体部は、発泡又は有孔ポリテトラフルオロエチレンを含む、請求項2に記載のグラフト。
- 身体管腔内に放出可能な前記治療薬の量は、約10μg〜約100mgの範囲内にある、請求項2に記載のグラフト。
- 前記治療薬は、約7日〜約12ヶ月間、身体管腔内に輸送されるように構成されている、請求項2に記載のグラフト。
- 前記少なくとも一種の治療薬は、内皮形成促進薬、血管新生促進薬、抗血栓薬、抗動脈瘤薬、抗感染薬、抗炎症薬、抗再狭窄薬、化学療法剤、及び抗癌剤からなる群から選択された一種又は二種以上の薬剤を含む、請求項2に記載のグラフト。
- 前記膨張媒体は、治療薬を収容するホストポリマーを含む、請求項2に記載のグラフト。
- 前記治療薬は、前記ホストポリマーを介した放散により放出されることが可能な、請求項10に記載のグラフト。
- 前記治療薬は、前記ホストポリマーの減成により放出されることが可能な、請求項10に記載のグラフト。
- 前記グラフト本体部は、前記ホストポリマーの塊の輸送を阻止することが可能な生体適合性材料を含む、請求項10に記載のグラフト。
- 前記ホストポリマーは、グラフトの留置若しくは移植の前、留置若しくは移植の間、又は留置若しくは移植の後、前記膨張可能なチャネル内に導入されることが可能な、請求項10に記載のグラフト。
- 前記ホストポリマーは、ポリエチレングリコール、ポリエチレングリコールジアクリレート、エトキシル化トリメチロールプロパントリアクリレート、プルロニックポリオキシマー(polyoxymer)、アクリルアミド、ポリエチレンオキシド、ポリプロピレンオキシド、ポリビニルアルコール、ポリエチレン/ビニルアルコール共重合体、ポリアクリル酸、ポリエチレン/アクリル酸共重合体、ポリエチルオキサゾリン、ポリビニルピロリドン、ポリエチレン/ビニルピロリドン共重合体、ポリマレイン酸、ポリエチレン/マレイン酸共重合体、ポリアクリルアミド、及びポリエチレンオキシド/ポリプロピレンオキシド共重合体を含む群から選択されたもう一種の材料を含む、請求項10に記載のグラフト。
- 前記膨張媒体は液体からなる、請求項1に記載のグラフト。
- 前記膨張媒体は硬化性の液体からなる、請求項1に記載のグラフト。
- 前記膨張媒体は、約3分〜約12分の範囲の硬化時間、及び約345kPa〜2758kPa(約50psi〜約400psi)の範囲の硬化後の弾性係数を有する、請求項17に記載のグラフト。
- 前記チャネルは、螺旋、長手方向に延びるチャネル、及び周方向に延びるリングから選択された一つ又は二つ以上の構成を有する、請求項1に記載のグラフト。
- 前記グラフト本体部の近位端及び遠位端のいずれかに配置され、且つ前記少なくとも一個のチャネルと流体が流れるように連通する少なくとも一個の膨張可能な多孔性のカフをさらに有する、請求項1に記載のグラフト。
- 近位端及び遠位端を有し、該近位端と遠位端との間に少なくとも一個の膨張可能な多孔性チャネルを画成するグラフト本体部と、
前記グラフト本体部の近位端又は遠位端に固着され、一個又は二個以上の接続要素を有する接続部材と、
前記接続部材の前記一個又は二個以上の接続要素に連結したもう一個の近位端側ステント接続要素を有するステントと、
前記膨張可能なチャネル内に導入されるように構成された、少なくとも一種の治療薬を含有する膨張媒体と、
を備えるグラフト。 - 近位端及び遠位端を有し、且つ少なくとも一個の膨張可能な多孔性チャネルを画成するグラフト本体部を提供する工程と、
前記グラフト本体部を身体の管腔内に移植する工程と、
少なくとも一種の治療薬を含有する膨張媒体によって前記多孔性チャネルを膨張させる工程と、
を含む、治療薬を送達する方法。 - 前記多孔性チャネルは、グラフトの留置若しくは移植の前、留置若しくは移植の間、又は留置若しくは移植の後に膨張される、請求項22に記載の方法。
- 前記膨張媒体から前記多孔性チャネルを通して前記治療薬を輸送して、前記治療薬を身体管腔内に放出する工程をさらに含む、請求項22に記載の方法。
- 前記治療薬を前記グラフト本体部の管腔側及び反管腔側のいずれか一方より身体管腔内に放出する工程をさらに含む、請求項24に記載の方法。
- 前記多孔性チャネルは、様々な多孔度を有する発泡又は有孔ポリテトラフルオロエチレンを含む、請求項24に記載の方法。
- 前記膨張媒体は、治療薬を収容するホストポリマーを含む、請求項24に記載の方法。
- 前記ホストポリマーを介した放散により前記治療薬を放出する工程をさらに含む、請求項27に記載の方法。
- 前記ホストポリマーの減成により前記治療薬を放出する工程をさらに含む、請求項27に記載の方法。
- 前記グラフト本体部は、前記ホストポリマーの塊の輸送を阻止する、請求項27に記載の方法。
- 前記ホストポリマーは、液体として注入されるポリエチレングリコールを含む、請求項27に記載の方法。
- 前記膨張媒体は、約3分〜約12分の範囲の硬化時間、及び約345kPa〜2758kPa(約50psi〜約400psi)の範囲の硬化後の弾性係数を有する、請求項31に記載の方法。
- 前記少なくとも一種の治療薬は、内皮形成促進薬、血管新生促進薬、抗血栓薬、抗動脈瘤薬、抗感染薬、抗炎症薬、抗再狭窄薬、化学療法剤、及び抗癌剤からなる群から選択された一種又は二種以上の薬剤を含む、請求項22に記載の方法。
- 前記治療薬を約7日〜約12ヶ月間、身体管腔内に放出する工程をさらに含む、請求項22に記載の方法。
- グラフトと、請求項22〜34のいずれか一項に記載の、治療薬を送達するために前記グラフトを移植及び膨張させる方法に関する使用説明書と、を備えたキット。
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US7803178B2 (en) | 2010-09-28 |
WO2005074547A3 (en) | 2005-10-13 |
US20110137404A1 (en) | 2011-06-09 |
JP5207629B2 (ja) | 2013-06-12 |
US8267989B2 (en) | 2012-09-18 |
JP2007519491A (ja) | 2007-07-19 |
EP1708647A4 (en) | 2008-09-03 |
EP1708647A2 (en) | 2006-10-11 |
US20050171593A1 (en) | 2005-08-04 |
JP5468030B2 (ja) | 2014-04-09 |
WO2005074547A2 (en) | 2005-08-18 |
CA2546525A1 (en) | 2005-08-18 |
EP2332493A1 (en) | 2011-06-15 |
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