US20020049490A1 - Single-piece endoprosthesis with high expansion ratios - Google Patents

Single-piece endoprosthesis with high expansion ratios Download PDF

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Publication number
US20020049490A1
US20020049490A1 US09837353 US83735301A US2002049490A1 US 20020049490 A1 US20020049490 A1 US 20020049490A1 US 09837353 US09837353 US 09837353 US 83735301 A US83735301 A US 83735301A US 2002049490 A1 US2002049490 A1 US 2002049490A1
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endoprosthesis
plurality
prosthesis
longitudinal members
beams
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US09837353
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David Pollock
Arnold Escano
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EndoVascular Technologies Inc
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EndoVascular Technologies Inc
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, E.G. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/82Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/86Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
    • A61F2/90Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure
    • A61F2/91Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes
    • A61F2/915Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes with bands having a meander structure, adjacent bands being connected to each other
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, E.G. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/82Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/86Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
    • A61F2/90Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure
    • A61F2/91Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, E.G. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/04Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts
    • A61F2/06Blood vessels
    • A61F2/07Stent-grafts
    • A61F2002/075Stent-grafts the stent being loosely attached to the graft material, e.g. by stitching
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, E.G. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/82Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/86Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
    • A61F2/90Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure
    • A61F2/91Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes
    • A61F2/915Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes with bands having a meander structure, adjacent bands being connected to each other
    • A61F2002/91508Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes with bands having a meander structure, adjacent bands being connected to each other the meander having a difference in amplitude along the band
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, E.G. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/82Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/86Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
    • A61F2/90Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure
    • A61F2/91Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes
    • A61F2/915Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes with bands having a meander structure, adjacent bands being connected to each other
    • A61F2002/91516Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes with bands having a meander structure, adjacent bands being connected to each other the meander having a change in frequency along the band
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, E.G. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/82Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/86Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
    • A61F2/90Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure
    • A61F2/91Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes
    • A61F2/915Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes with bands having a meander structure, adjacent bands being connected to each other
    • A61F2002/91533Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes with bands having a meander structure, adjacent bands being connected to each other characterised by the phase between adjacent bands
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, E.G. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/82Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/86Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
    • A61F2/90Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure
    • A61F2/91Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes
    • A61F2/915Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes with bands having a meander structure, adjacent bands being connected to each other
    • A61F2002/91533Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes with bands having a meander structure, adjacent bands being connected to each other characterised by the phase between adjacent bands
    • A61F2002/91541Adjacent bands are arranged out of phase
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, E.G. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/82Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/86Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
    • A61F2/90Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure
    • A61F2/91Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes
    • A61F2/915Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes with bands having a meander structure, adjacent bands being connected to each other
    • A61F2002/9155Adjacent bands being connected to each other
    • A61F2002/91558Adjacent bands being connected to each other connected peak to peak
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, E.G. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/82Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/86Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
    • A61F2/90Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure
    • A61F2/91Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes
    • A61F2/915Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes with bands having a meander structure, adjacent bands being connected to each other
    • A61F2002/9155Adjacent bands being connected to each other
    • A61F2002/91575Adjacent bands being connected to each other connected peak to trough
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, E.G. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2230/00Geometry of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2230/0002Two-dimensional shapes, e.g. cross-sections
    • A61F2230/0004Rounded shapes, e.g. with rounded corners
    • A61F2230/0013Horseshoe-shaped, e.g. crescent-shaped, C-shaped, U-shaped

Abstract

A new endoluminal prosthesis provides for a compressible and expansible single-piece thick walled cylindrical structure. The cylindrical structure is comprised of curved elongated beams which intermittently merge with adjacent curved elongated beams. Each beam has a radial thickness greater than the circumferential width. The configuration of the curved beams reduces stress concentrations in the expanded and compressed condition of the prosthesis. Features are provided for high expansion ratios allowing the prosthesis to collapse into a very small diameter and expand into a very large diameter.

Description

    RELATED APPLICATIONS
  • This Application is a continuation-in-part of application Ser. No. 09/546,966 filed Apr. 11, 2000 entitled “Single Piece Thick-Walled Endoprosthesis.”[0001]
  • BACKGROUND OF THE INVENTION
  • This invention relates to medical devices for the treatment of vascular diseases generally referred to as endoluminal prostheses. A variety of such devices are available for a broad range of treatment modalities. Examples of such devices are “vascular grafts” and “stents.” Vascular grafts are typically used to treat weakened areas of vessels known as aneurysms. Stents are typically used to prop open a narrowed or stenosed vessel. [0002]
  • Stents and grafts may be delivered intraluminally through a narrow incision or a puncture in the patient's skin. The device may be mounted on a delivery catheter and inserted into a corporeal lumen through the skin. The device and catheter are then advanced through the various lumens to the site to be treated. To accomplish this, stents and grafts are generally collapsible for delivery and expansible for treatment. [0003]
  • Vascular grafts are primarily composed of an artificial lumen which isolates the natural lumen from the flow of bodily fluids, such as blood. Grafts may incorporate attachment devices to secure the graft into the natural lumen and keep the graft expanded. Stents are typically formed of metallic wire or bars configured in a cylinder. Prior art stents have generally taught that the resulting thickness of the cylinder should be kept small to provide as large of an open lumen as possible. They have also taught the use of wide bar elements to compress plaque or tissue and hold it against the lumen wall. These stents expand by configuring the elements of the cylindrical structure such that they bend from a generally longitudinal orientation while compressed to a more circumferential orientation while expanded. These bending elements are then connected by elements which typically lie and remain in a circumferential orientation. This configuration limits the compressibility of the prior art stents because elements in a circumferential orientation cannot be tightly packed and thin elements in a longitudinal orientation tend to overlap while compressed. [0004]
  • The configuration of prior art stents causes stress concentrations by limiting the portions of the structure that bend during expansion and compression. These stents have taught the use of configurations which limit bending either to circumferential members or to the areas immediately about such members. Such configurations limit the ability of the prior art stents to expand through very high expansion ratios. [0005]
  • At least one prior art device has incorporated the benefits of a cylindrical structure composed of flat wires. This device is described in U.S. Pat. No. 5,993,482 (Chuter) as a Flat-Wire Stent. The teachings of that patent are hereby incorporated by reference. [0006]
  • The Chuter flat-wire stent teaches a stent comprised of flat-wires which results in a relatively thick-walled structure. This approach has proven to have many advantages. The Chuter flat-wire stent exhibits a greater expansion ratio than other prosthesis. This is due in part to superior packability when compressed. Other advantages include a reduction in stress concentrations while expanded and the minimizing of foreshortening during expansion. [0007]
  • SUMMARY OF THE INVENTION
  • Briefly and in general terms, the present invention relates to an improved endoluminal prosthesis. This prosthesis may function as a stent or as a means to secure an endoluminal graft in a corporeal lumen such as an artery. Stents typically are used to ensure the patency of diseased corporeal lumens by resisting collapse and occlusion. Endoluminal grafts typically are used to isolate diseased corporeal lumens from the flow of bodily fluids. [0008]
  • The prosthesis incorporating the present invention is configured as a series of intermittently merging curved beams (e.g. leaf springs) formed into a cylinder. This cylindrical structure is capable of being compressed into a small diameter and expanded into a large diameter. To facilitate both compression and expansion the beams have a cross-section which is greater in the radial direction (thickness) than in the circumferential direction (width). The beams of the present invention are also generally continuously curved to reduce or minimize stress concentrations in the structure. The beams straighten during compression until they are nearly straight. [0009]
  • While compressed the thickness of the beams prevents overlap. In a tightly packed configuration, the curved beams straighten out, come together and generally lie flat in close proximity to each other. The beams resist overlap because the thickness of each beam requires substantial radial displacement to move over or under the adjacent beam. The compression of the prosthesis may be maximized by configuring the beams to fit together tightly in a collapsed condition. [0010]
  • While expanded and during expansion, the thickness of the beams and the configuration of the beams increase the strength of the prosthesis and reduce or minimize stress concentrations. Thicker beams provide for more material in the radial direction to prevent radial collapse. The curved configuration of the beams spreads the bending due to expansion throughout the entire length of the beam. This prevents one area of the beam from generating most of the bending and withstanding resultant stress concentrations. [0011]
  • In various preferred embodiments of the present invention, further improvements distribute stresses throughout the beams more evenly. For example, the extreme ends of adjacent beams may be connected by a loop or eyelet connector. In such an embodiment the stresses from bending due to compression of the prosthesis concentrate in the loop portion of the connector until the lower portion of the connector just adjacent to the loop portion closes on itself, bringing the adjacent beams into contact. Further compression after that point concentrates stresses in the beam below the loop. A similar result can be achieved by configuring the beams to form a significant area of contact adjacent other types of connectors prior to full compression of the prosthesis. [0012]
  • The present invention is a single integrated structure without welds or fasteners. This may be accomplished by removing almond-shaped cells from a thick-walled cylinder. This eliminates the need to construct the prosthesis from individual pieces and possible weak points created by fasteners or joining. [0013]
  • In a first embodiment, the prosthesis may have curved beams which are only merged to adjacent beams at their end points. This creates a single repetitive pattern around the circumference of the cylinder, with each beam merged to opposite adjacent beams at opposite end points. This embodiment may be viewed as the simplest structure to include the invention described herein. It includes alternating half-cells divided by curved beams. This embodiment is not necessarily short, as the beams may be of any length. However, it may be viewed as the shortest configuration for any given cell size. [0014]
  • In a second embodiment, the prosthesis may have curved beams like leaf springs which are repeatedly merged to alternating adjacent beams throughout their length. This second embodiment may also be viewed as the single repetitive pattern of the first embodiment repeated throughout the length of the prosthesis. For example, a prosthesis may be comprised of two or more of the single pattern prosthesis connected end to end. Instead of actually connecting the prosthesis, they may be formed as a single structure. Thereby, the beams could be viewed as continuous throughout the length of the prosthesis. The beams would then have many curved portions which bring them in connection with alternating adjacent beams at merge sections. [0015]
  • The prosthesis may also embody these curved beams forming individual cylindrical elements and connected together by separate elements. Thus, a variety of prosthesis may be formed by connecting different cylindrical elements together with different connecting elements. One configuration includes cylindrical elements having curved beams which are only merged to adjacent beams at their end points connected to cylindrical elements having curved beams which are repeatedly merged to alternating adjacent beams throughout their length. This provides a prosthesis having varying strength and flexibility throughout its length. [0016]
  • In the compressed condition the prosthesis may be intraluminally inserted and delivered within a corporeal lumen. Once delivered to the site to be treated, the prosthesis may be expanded and imbedded into the interior of the lumen. Various methods for intraluminally expanding prostheses are well-known in the art. Expansion due to spring forces is particularly suited for this invention. The super-elastic properties of Nickel-Titanium alloys (for example Nitinol) allow a great amount of expansion and compression of structures without permanent deformation. Thus a prosthesis made of such material may be compressed into a very small configuration, and will spring back into a preset form when released. Other known methods of expansion include balloon expansion, and expansion due to the highly elastic properties of certain alloys. [0017]
  • The present invention may also be balloon expandable. To expand the prosthesis by balloon an angioplasty-type dilation catheter is inserted through a compressed or not-fully expanded prosthesis until the balloon portion of the catheter is longitudinally aligned within the prosthesis. The balloon is then expanded forcing the prosthesis radially outwardly. [0018]
  • Once expanded the prosthesis remains in the expanded condition, and the strength of the prosthesis resists radial collapse. When used alone the prosthesis can expand and resist re-collapse of a previously collapsed or stenosed corporeal lumen. When used in combination with a graft, the prosthesis can maintain the graft open and secure the graft to the vessel. [0019]
  • Additional preferred embodiments of the present invention may provide benefits for high-expansion ratios. That is, the prosthesis may be configured to readily withstand high degrees of expansion and compression. Prostheses having loop or eyelet connectors according to this invention may also include beams of different lengths. Alternating pairs of beams having longer lengths and shorter lengths provide a more controlled expansion. This configuration also permits the eyelets of the shorter length beams to nestle below the eyelets of the longer length beams upon compression. A further feature aiding the expansion of the prosthesis includes varying the widths of the individual beams. For example, configuring beams having longer lengths with greater widths will improve the prosthesis ability to accomplish high expansion. Furthermore, varying the width along the length of the beam may also improve the expansion and compression abilities of prosthesis. [0020]
  • Other configurations of the prosthesis may be beneficial when the prosthesis is used in combination with a graft. The ends of prosthesis which are to be configured within a graft may include a flattened bulbous tail. Such an extension of the prosthesis prevents wear on the fabric of the graft. Eyelets on the ends of the prosthesis may also be used for stitching the prosthesis together with the graft. Eyelets provide a good anchoring point for such stitching. Various combinations of connected prosthesis according to the present invention may be used within grafts. [0021]
  • These and other advantages of the invention will become more apparent from the following detailed description of the preferred embodiments. When taken in conjunction with the accompanying exemplary drawings the person of skill in the art will appreciate that various embodiments incorporate the present invention. [0022]
  • BRIEF DESCRIPTION OF THE DRAWINGS
  • FIG. 1 is a perspective view of a first embodiment of the prosthesis in an expanded condition. [0023]
  • FIG. 2 is a perspective view of the first embodiment of the prosthesis in a compressed condition. [0024]
  • FIG. 3 is a cross-sectional view of the first embodiment of the prosthesis in an expanded condition. [0025]
  • FIG. 4 is a cross-sectional view of the first embodiment of the prosthesis in a compressed condition. [0026]
  • FIG. 5 is a perspective view of a second embodiment of the prosthesis. [0027]
  • FIG. 6 is a side view of a third embodiment of the prosthesis. [0028]
  • FIG. 7 is a top view of a portion of a flat pattern for the prosthesis. [0029]
  • FIG. 8 is a side view of a fourth embodiment of the prosthesis. [0030]
  • FIG. 9 is a side view of a vascular graft secured in a corporeal lumen by a prosthesis. [0031]
  • FIG. 10 is a side view of a prosthesis embedded in a corporeal lumen. [0032]
  • FIG. 11 is a perspective view of a thick-walled cylindrical tube with cells designed therein. [0033]
  • FIG. 12 is a flat pattern view of a portion of a prosthesis embodying variable thickness beams. [0034]
  • FIG. 13 is a flat pattern view of a portion of a prosthesis including alternative embodiments of variable thickness beams. [0035]
  • FIG. 14 is a flat pattern view of a portion of a prosthesis including additional alternative embodiments of variable thickness beams. [0036]
  • FIG. 15 is a flat pattern view of a portion of a prosthesis including additional alternative embodiments having varying flexibility. [0037]
  • FIGS. 16[0038] a and 16 b are side views of a first alternative embodiment of the beam ends and connector.
  • FIGS. 17[0039] a and 17 b are side views of a second alternative embodiment of the beam ends and connector.
  • FIG. 18 is a flat pattern view of a first embodiment of a prosthesis having the alternative beam end connectors shown in FIGS. 16[0040] a and 16 b.
  • FIG. 19 is a flat pattern view of a second embodiment of a prosthesis having the alternative beam end connectors shown in FIGS. 16[0041] a and 16 b.
  • FIG. 20 is a flat pattern view of the prosthesis of FIG. 19 in a collapsed state. [0042]
  • FIG. 21 is a flat pattern view of a prosthesis from within a vascular graft.[0043]
  • DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS
  • The following description, as well as the Figures, describe embodiments of the invention. These embodiments are exemplary of the inventors known uses of the invention, and are not intended to limit the scope of the claimed invention. Those skilled in the art of endoluminal devices will appreciate that the invention described herein may encompass many embodiments. [0044]
  • As shown in the Figures, the present invention relates to an endoluminal prosthesis. More particularly, the invention is an expandable and compressible prosthesis for repairing corporeal lumens. The prosthesis may be formed from a metallic cylinder by removal of cells. [0045]
  • As depicted in FIGS. 1 and 2, the result of removing cells [0046] 20 from the metallic cylinder 22 is a prosthesis 24 having a series of curved beams 26 and merge sections 28. It is to be recognized that the prosthesis 24 shown in FIG. 2 can be compressed, where desired, to a smaller diameter such that the cells 20 are essentially defined by slits (not shown).
  • The beams [0047] 26 are generally longitudinal members circumferentially spaced about the prosthesis 24. In one embodiment, as depicted in FIG. 5, the ends of these beams 26 merge with the ends of circumferentially adjacent beams to form the merge sections 28 only at the ends of the prosthesis. The ends of each beam 26 merge with one adjacent beam on the forward end 30 and the opposite adjacent beam on the rear end 32. This creates a single circumferential pattern of staggered half-cells 21 divided by beams 26. (For comparison, a full cell 25 is identified in FIG. 1). Preferably, the beams 26 each include at least two curved segments 34 of opposite orientations and an inflection point 36 near the mid-point of the beams.
  • In the embodiment depicted in FIG. 5, the merge sections [0048] 28 include either the forward ends 30 or rear ends 32 of two such beams 26 as well as the ends of the prosthesis. These merge sections 28 are also circumferentially spaced about the prosthesis 24, preferably equidistantly.
  • The single pattern as depicted in FIG. 5 may be extended to build longer prostheses [0049] 24. This may be done by extending the length of each beam 26 with additional curved segments 34 and forming additional merge sections 28. This forms the prosthesis 24 as depicted in FIGS. 1 and 2. Alternatively, multiple single patterns may be connected with a separate connector element 58. The connector elements 58 may have various configurations and be distributed throughout the prosthesis 24 in a variety of arrangements. Such a prosthesis 24, having “S”-shaped connector elements at each merge section is depicted in FIG. 6. Other embodiments (not shown) may have connectors with other shapes only at every second or third merge section. Such embodiments may have advantages in providing longitudinal flexibility to the prosthesis 24.
  • In the embodiments depicted in FIGS. 1 and 2 the beams [0050] 26 may extend beyond the first merge sections 28 to form additional merge sections 28. This configuration may also be viewed as the merge sections 28 connected end-to-end with opposite facing merge sections 28. This may provide for a prosthesis 24 of greater lengths. The continuous beams 26 of this embodiment merge with adjacent beams 26 repeatedly and alternately throughout their length. The continuous beams are comprised of multiple curved segments 34. The merge sections 28 may also contain flat segments (not shown).
  • As depicted in FIGS. 3 and 4 the prosthesis [0051] 24 is preferably formed from a thick-walled cylinder 22. The difference between the external radius of the cylinder and the internal radius of the cylinder defines a radial thickness 40. Preferably, the cells 20 of the prosthesis 24 are removed such that the remaining beams 26 have a width (measured circumferentially) 42 that is less than the radial thickness 40. A typical design might have dimensions of 0.007″ circumferential width 42 and 0.014″ radial thickness 40. This defines a deep cross-section for the beams 26. To take advantage of the benefits of this invention, the radial thickness 40 of the beams 26 needs to be substantially greater than the circumferential width 42. Preferably, the radial thickness 40 will be at least one and one-third (1⅓) times the circumferential width 42.
  • A theoretical flat pattern of the beams [0052] 26 and merge sections 28, as depicted in FIG. 7 reveals the novel configuration of the beams. Preferably, each beam 26 is continuously curved, alternating between curves 56 of opposite orientations throughout its length. In this ideal configuration, the beams 26 form inflection points 36 between the opposite facing curves 56.
  • Each curve [0053] 56 in each beam 26 is defined by two radii, an internal radius 64 and an external radius 66. The difference between these radii define the circumferential width 42 of the beam 26.
  • The continuously curved configuration of beams [0054] 26 disposed longitudinally along a cylinder, provides some of the unique properties of this invention. As the cylinder is expanded from a partially compressed configuration 50, the radii of each curve 56 within each beam 26 becomes smaller as the beams spread apart. Since the beams 26 are ideally continuously curved, the bending is spread throughout the entire length of the beam 26. This spreads the resultant stresses throughout the beam 26 and reduced or minimizes stress concentrations.
  • As depicted in FIGS. 2 and 4 the use of deep cross-sections has significant advantages for collapsing the prosthesis [0055] 24 in preparation of intraluminal delivery. The deep cross-section allows for significant compression without incidental overlapping of the beams 26. The large radial thickness 40 of the beams 26 prevents one beam from extending over the top of another.
  • As depicted in FIGS. 1 and 3 there are also advantages to the use of deep cross-sections in expansion of the prosthesis [0056] 24. In general, as cylindrical, expandable prosthesis are expanded, longitudinally-oriented members of the collapsed prosthesis tend to bend circumferentially. The relatively narrow width of the beams 26 of the present prosthesis 24 permits circumferential bending without inducing high stress concentrations. The large overall cross-sectional area of the beams 26 prevents recompression of the prosthesis 24. The configuration of the curved segments 34 spreads the stresses induced by expansion across the entire length of the beams 26, also reducing stress concentrations. In a preferred embodiment, the prosthesis is self-expandable. Alternatively, the prosthesis may be expanded by balloon.
  • FIGS. 1 and 3 and FIGS. 2 and 4 depict two separate configurations of the prosthesis [0057] 24. The prosthesis 24 of the present invention has an expanded configuration 44 while deployed in the lumen as depicted in FIGS. 1 and 3. This configuration has a large inner diameter which allows maximum patency of the lumen 46 to be treated. The prosthesis 24 of the present invention also has a second partial compressed configuration 50 as depicted in FIGS. 2 and 4. This configuration is beneficial to the intraluminal delivery of the device which is facilitated by a smaller external diameter.
  • In a typical procedure the prosthesis [0058] 24 will be constrained in the compressed configuration 50 within a catheter. This catheter may then be inserted into a small diameter lumen 46 such as the femoral artery. To prevent damage to such an artery the entire system of catheter and prosthesis 24 must have as small a diameter as possible. Small diameters also facilitate the navigation of the prosthesis 24 and catheter through arduous vasculature. Once inserted into such an artery, the catheter and prosthesis 24 may be advanced through the corporeal lumens, possibly to larger arteries for treatment. The prosthesis 24 may then be released from the catheter. Spring forces within the compressed prosthesis of a self-expanding version will force the prosthesis from the partially compressed configuration 50 into the expanded configuration 44. The spring forces may be great enough to expand the lumen of the diseased vessel as the prosthesis 24 expands. These forces will also be great enough to impinge the beams 26 into the tissues of the vessel. This impinging secures the prosthesis 24 and possibly an associated graft 52 into place.
  • Another embodiment of the prosthesis [0059] 24, depicted in FIG. 8, has a conical rather than cylindrical shape while in the expanded configuration 44. In this embodiment, the prosthesis 24 has a cylindrical shape in the compressed configuration 50. Upon expansion, however, a broader end 60 of the prosthesis 24 expands more than a narrower end 62. This conical embodiment of the prosthesis 24 is useful in similarly shaped lumens and various configurations of grafts. The broader end 60 may include cells 20 that are longer and wider in the expanded configuration 44, than those at the narrower end 62.
  • The prosthesis [0060] 24 of the current invention may be used in a variety of procedures, two of which are depicted in FIGS. 9 and 10. As depicted in FIG. 9 one or more prostheses embodying the present invention may be used in the treatment of aneurysms. An aneurysm is a weakening of the vessel wall of a vein or artery, causing a sack to form in the lumen 46 or possibly rupture. When an aneurysm forms in the abdominal aorta, the condition can be life-threatening. A known treatment for aneurysms is the intraluminal delivery and implantation of a vascular graft 52. Such a graft 52 bypasses the sack formed by the aneurysm and isolates the weakened tissues from the blood flow. To operate properly, the graft 52 must have leak-proof fixation to the healthy vascular tissue on either side of the aneurysm. The prosthesis 24 described herein may provide that fixation at one or more ends of the graft 52. The prosthesis 24 may also extend throughout the length of the graft 52. When expanded the prosthesis 24 may compress the flexible graft material 52 against the arterial wall. Preferably, the prosthesis 24 extends further from the aneurysm than the graft 52 so that parts of the prosthesis 24 are imbedded in healthy tissue. This configuration maintains the patency of the artificial lumen of the graft 52 as well as securing the graft in place by forcing the end of the graft against the wall of the lumen 46. The prosthesis 24 also ensures a leak-proof seal.
  • As depicted in FIG. 10, a prosthesis [0061] 24 embodying the present invention may be used to treat a stenosis or collapse of the lumen 46. Stenosis is often caused by the gradual occlusion of veins or arteries through the build-up of plaque. Preferably a single prosthesis 24 is inserted into the diseased vessel while mounted within a catheter. When the prosthesis 24 is at the location of the narrowing, the prosthesis 24 may be expanded. As depicted in FIG. 10 the spring forces of the prosthesis are preferably sufficient to expand the narrowed vessel. The prosthesis 24 is thereby forced into the tissues of the lumen 46 to secure the prosthesis 24 in place. The structure of the prosthesis 24 resists collapse after expansion.
  • The prosthesis [0062] 24 may be manufactured in the compressed configuration 50 as in FIG. 2, or in the expanded configuration 44 as in FIG. 1 or in any configuration in between. The manufacturing procedure requires the removal of cells 20 from a thick-walled cylinder 22. This may be accomplished with several known manufacturing methods such as laser cutting, chemical etching, photo-etching, electrical discharge machining (EDM) and mechanical means. Two materials found to be particularly suited to this application are implantable stainless steel, and Nickel-Titanium alloys such as Nitinol.
  • As depicted in FIG. 11, each cell [0063] 20 of the endoprosthesis 24 may consist of two sides 54 having three curves 56, and two inflection points 36. Such a configuration produces almond-shaped cells. There may also be flat portions (not shown) designed into the cell 20. These cells 20 are then designed on the thick walled cylinder 22 in a pattern which repeats along the length of the cylinder 22. This pattern is then repeated with a longitudinal stagger of half a cell 20 around the circumference of the cylinder 22. The pattern also includes half cells at each end of the tube. Upon removal of the cells 20 the remaining material constitutes the prosthesis 24 described herein.
  • The prosthesis [0064] 24 may be formed from a thick walled cylinder 22 approximately the size of the compressed configuration 50. This thick walled cylinder 22 may be a Nickel Titanium alloy. Cells 20 are laser cut into the thick walled cylinder 22 while the thick walled cylinder 22 is mounted over a wire. The cells 20 are formed in a long narrow configuration, with each of the curves 56 having large radii.
  • After the cells [0065] 20 are cut into the thick walled cylinder 22, the prosthesis 24 is cleaned and deburred to eliminate manufacturing irregularities. This may include blasting techniques, acid etching, ultrasonic cleaning and/or other well known methods of cleaning.
  • The prosthesis may then be stretched into more expanded configurations. One method of expanding this prosthesis is by mechanically stretching it over a mandrel. The mandrel may be specifically designed with pins to maintain the desired curvature of the beams. Once stretched the prosthesis is annealed to set the new expanded shape of the prosthesis. Annealing can be accomplished by heating the prosthesis within a variety of media such as air, molten salt, inert gas or vacuum. Annealing at 500-550° C. is appropriate for Nickel-Titanium alloys. After stretching the prosthesis [0066] 24 is cleaned again. This process of stretching, annealing and cleaning can be repeated until the desired configuration is obtained. Once the desired configuration has been obtained, the prosthesis is electropolished by any of the well-known methods.
  • Alternatively, a prosthesis [0067] 24 may be formed from a Nickel Titanium thick walled cylinder 22 approximately the size of expanded configuration. In this process cells 20 are cut into the thick walled cylinder in a shorter and wider configuration. This method would eliminate the need to stretch and anneal the prosthesis 24 to achieve the expanded configuration 94.
  • As best seen in FIGS. [0068] 12-14, it is also contemplated that the beams of a prosthesis may embody variable widths beams or struts 70 and generally uniform width beams or struts 71. The incorporation of variable width struts 70 into a prosthesis facilitates uniform expansion. For example, to achieve uniform expansion, it is desirable to have struts 70 of the same width meeting at connecting junctions 72. Asymmetric prosthesis portions 74, 76 as shown in FIGS. 12 and 13 may further require the strut 70 to embody a width that gradually varies along the length of the strut 70. Moreover, as shown in FIG. 14, where a prosthesis portion 78 embodies a plurality of adjacent oriented cells 80, the point of connection 82, 83 between adjacent cells 80 may be varied in length, for example to accommodate a hole 84. To facilitate uniform expansion of such a prosthesis portion 78, the struts 70 extending from a relatively shorter point of connection 82 between adjacent cells 80 can embody a tapering thickness.
  • The novel features of the present invention may be applied to configure a prosthesis having variable properties throughout the length of the prosthesis. As an example, and as depicted in FIG. 15, the flexibility of the prosthesis [0069] 24 may vary along the length of the prosthesis. To accomplish this, connector elements 58 may be used to combine segments 90 of the prosthesis 24. Each segment 90 may be composed of curved beams 26 in the various configurations described above. In a preferred embodiment, a segment 90 composed of full cells 20 may be combined with multiple segments 90 composed of half-cells 21. The portion of the prosthesis 24 composed of half-cell 21 segments 90 will tend to be significantly more flexible longitudinally and slightly more flexible radially. The invention includes any combination of full cells and half-cells in a prosthesis including, but not limited to, full cells between half-cells.
  • One application of a prosthesis [0070] 24 having variable flexibility throughout its length is for the support of a vascular graft 52. In such an application, the more flexible segments 90 of the prosthesis 24 may be configured to support the artificial lumen 46 of the graft 52. The less flexible segment 90 of the prosthesis 24 may be configured to extend beyond the artificial lumen 46 and into the patients natural lumen. In this manner, the less flexible segments 90 help secure the graft 52 into place, while the more flexible segments 90 support the material of the graft 52.
  • The invention described herein may also embody features to facilitate the high ratios of expansion possible with this prosthesis [0071] 24. As depicted in FIGS. 16a and 16 b, as well as FIGS. 17a and 17 b, the ends 92 of the beams 26 may be connected in a manner which evenly distributes the stresses incurred by expansion and compression.
  • An eyelet or loop connector [0072] 94 (shown in FIGS. 16a and 16 b) may connect the ends of the beams 26. These eyelet connectors 94 distribute stresses from compression of the prosthesis 94. As the prosthesis 24 is initially compressed and adjacent beams 26 are brought together, the bending and resultant stresses are initially concentrated in the eyelet or loop portion of the connector 94. Eventually, a contact area 96 is formed at the edge of the eyelet connector 24. As the prosthesis 24 is further compressed and adjacent beams 26 are brought even closer together, the bending and resulting stresses are now concentrated at the ends of the beams 26 near the contact area 96. Even further compression may relieve the stresses in the eyelet connector 24 by creating a fulcrum at the contact area 96.
  • A prosthesis [0073] 24 composed entirely of eyelet connectors 94, as depicted in FIG. 18, may facilitate the distribution of stresses induced by high expansion ratios. Thus, the prosthesis 24 of the present invention may be used in particularly large corporeal lumens, such as the abdominal aorta. This same prosthesis 24 may also be introduced into relatively small corporeal lumens, such as the femoral artery. Such an application requires the prosthesis to transition between a highly compressed state for insertion into the femoral artery, to a highly expanded state for implantation into the abdominal aorta. This application, as well as others, induce high stresses on the prosthesis 24 through bending of the beams 26 in expansion and compression.
  • A similar distribution of the stresses may be accomplished by configuring the ends [0074] 92 of the beams 26 into increased contact end connectors 98 (FIGS. 17a and 17 b). In such a configuration (depicted in FIGS. 17a and 17 b), the ends 92 of the beam 26 connect together with a substantial area of contact 96 near the actual connection. As the prosthesis 24 is compressed, and the beams 26 are brought closer together, the stresses due to bending are concentrated in the beams 26 near the contact area 96. The contact area 96 expands as the beams 26 are brought closer together and the stress concentrations are thereby distributed along the length of the beams 26.
  • To further support high expansion ratios, the prosthesis [0075] 24 of the present invention may be configured to pack tightly for compression into a collapsed state. One example, as depicted in FIGS. 19 and 20 may utilize eyelet connectors 94 aligned to differing heights. That is, every other eyelet connector 94 may be configured upon beams 26 of a first, greater length 100, while each other eyelet connector 94 may be configured upon beams 26 of a second lesser length 102. Thus the eyelet connectors 94 configured upon beams at the second length would have their greatest width at the same location that the eyelet connectors 94 configured upon beams at the first length have their least width. In this manner the beams 26 and eyelet connectors 94 fit together in the most compact condition while compressed. Similar results may be accomplished by varying the thickness of the beams 26 and connectors 94.
  • Varying the circumferential width [0076] 42 of the beams 26 may also provide benefits in high expansion ratios. For example, using larger widths on beams 26 of a first, greater length 100 may help control the expansion of the prosthesis 24 and reduce stress concentrations. Varying the circumferential width 42 along the length of individual beams 26 may provide superior nesting when the prosthesis is provided with eyelet connectors 94.
  • Further configurations, as depicted in FIG. 21, may be advantageous when the prosthesis [0077] 24 is configured for use in a vascular graft 52. Eyelet connectors 94 may be used to provide an anchor for the stitching 104 between the graft 52 and the prosthesis 24. The merge sections 28 at the end of the prosthesis may include a flattened bulbous tail 106. These tails 106 reduce the wearing on the fabric of the graft 52. Tails 106 may also help control the expansion of the prosthesis 24. Instead of springing open when the ends of the prosthesis 24 are released, the tails 106 may remain constrained within a delivery catheter and provide the prosthesis 24 with a slower more controlled expansion.
  • While the present invention has been described herein in terms of a prosthesis for the repair of blood vessels, those of skill in the art will readily recognize that prostheses embodying the described invention can be used to treat a variety of corporeal lumens, for example the bronchial tree and intestines. The invention described herein is intended to be limited only by the claims that follow and not by any particular embodiment. [0078]

Claims (25)

    What is claimed is:
  1. 1. A collapsible cylindrical endoprosthesis comprising:
    a plurality of longitudinal members in a cylindrical arrangement, each having at least one end;
    a plurality of circumferential members connecting the ends of adjacent longitudinal members; and
    a plurality of opposed contact surfaces on adjacent longitudinal members near the circumferential members, with the opposed surfaces being oriented relative to each other, wherein, as the endoprosthesis is collapsed, the circumferential members bend until the opposed contact surfaces come together and then continued deflection of the longitudinal members produces stress at the contact surfaces.
  2. 2. The collapsible cylindrical endoprosthesis of claim 1, wherein the manner of bending distributes the stresses throughout the longitudinal members and circumferential members.
  3. 3. The collapsible cylindrical endoprosthesis of claim 1, wherein the circumferential members comprise a loop.
  4. 4. The collapsible cylindrical endoprosthesis of claim 1, wherein the circumferential members comprise an eyelet configuration.
  5. 5. The collapsible cylindrical endoprosthesis of claim 1, wherein the circumferential members comprise a merge section of the ends of adjacent longitudinal members.
  6. 6. The collapsible cylindrical endoprosthesis of claim 1, wherein the longitudinal members further comprise a width measured circumferentially and a thickness measured radially wherein the thickness is greater than the width.
  7. 7. A collapsible cylindrical endoprosthesis comprising:
    a plurality of longitudinal members arranged adjacently into a cylindrical configuration each having a first end section, a middle section and a second end section;
    a first a plurality of eyelets connecting adjacent longitudinal members at the first end sections;
    a second plurality of eyelets connecting adjacent longitudinal members at the second end sections; and
    a plurality of merge sections connecting adjacent longitudinal members at the middle section.
  8. 8. The collapsible cylindrical endoprosthesis of claim 7, wherein the first plurality of eyelets and the second plurality of eyelets connect the same longitudinal members forming pairs of longitudinal members connected at both the first ends and second ends.
  9. 9. The collapsible cylindrical endoprosthesis of claim 7, further comprising:
    opposed contact surfaces on the longitudinal members near the first plurality of eyelets and the second plurality of eyelets wherein the contact surfaces come together when the prosthesis is collapsed.
  10. 10. The collapsible cylindrical endoprosthesis of claim 9, wherein the first plurality of eyelets and the second plurality of eyelets bend while the endoprosthesis is collapsed until the contact surfaces come together and the longitudinal members bend thereafter.
  11. 11. The collapsible cylindrical endoprosthesis of claim 7, wherein the stresses due to collapsing the endoprosthesis are distributed between the longitudinal members, the first plurality of eyelets and the second plurality of eyelets.
  12. 12. The collapsible cylindrical endoprosthesis of claim 8, wherein alternating pairs of longitudinal members define a first longer length between the first end section and the middle section and a second shorter length between the first end section and the middle section.
  13. 13. The collapsible cylindrical endoprosthesis of claim 12, wherein alternating pairs of longitudinal members define a first longer length between the second end section and middle section, and a second shorter length between the second end section and the middle section.
  14. 14. The collapsible cylindrical endoprosthesis of claim 12, wherein upon collapsing the endoprosthesis the eyelets connecting alternating pairs of longitudinal members defining the second shorter length nestle below the eyelets connecting alternating pairs of longitudinal members defining the first longer length.
  15. 15. The collapsible cylindrical endoprosthesis of claim7, wherein each longitudinal member defines a width measured circumferentially and a thickness measured radially, wherein the thickness is greater than the width.
  16. 16. A compressible endoprosthesis configured to secure an endoluminal graft within a body lumen, comprising:
    a plurality of curved beams arranged longitudinally in a cylindrical structure, each beam having at least one end;
    a plurality of merge sections formed by adjacent curved beams merging together;
    at least one eyelet formed in a merge section at the ends of adjacent curved beams; and
    wherein at least one eyelet provides an anchor for stitching the endoprosthesis to the endoluminal graft.
  17. 17. The endoprosthesis of claim 16, further comprising:
    opposed contact surfaces on the curved beams near the at least one eyelet, wherein the contact surfaces come together when the endoprosthesis is compressed.
  18. 18. The endoprosthesis of claim 16, wherein the at least one eyelet is configured to distribute stress throughout the curved beams while the endoprosthesis is compressed.
  19. 19. An expandable endoprosthesis comprising:
    a plurality of curved beams arranged longitudinally in a cylindrical structure, each beam having at least one end;
    a plurality of merge sections formed by adjacent curved beams merging together; and
    at least one bulbous extension formed in a merge section at the ends of adjacent curved beams.
  20. 20. The endoprosthesis of claim 19, wherein the endoprosthesis is formed from a single integral structure.
  21. 21. A collapsible cylindrical endoprosthesis comprising:
    a plurality of curved longitudinal members in a cylindrical arrangement, each having a proximal end and a distal end;
    a plurality of proximal connections integrally formed by the proximal ends of adjacent longitudinal members;
    a plurality of distal connections integrally formed by the distal ends of adjacent longitudinal members; and
    the cylindrical endoprosthesis has a first diameter sized to compress against the interior of a corporeal lumen and a second smaller diameter sized to fit within a delivery catheter;
    wherein the cylindrical endoprosthesis withstands stresses induced by collapsing through bending of the curved longitudinal members.
  22. 22. The collapsible cylindrical endoprosthesis of claim 21, wherein the proximal connections further comprise a looped configuration.
  23. 23. The collapsible cylindrical endoprosthesis of claim 21, wherein the distal connections further comprise a looped configuration.
  24. 24. The collapsible cylindrical endoprosthesis of claim 21, wherein the plurality of curved longitudinal members further comprise pairs of opposed contact surfaces on adjacent members.
  25. 25. The collapsible cylindrical endoprosthesis of claim 21, further comprising:
    a plurality of bulbous extensions attached at the ends of the connections.
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US11110999 US7740653B1 (en) 2000-04-11 2005-04-20 Single-piece endoprosthesis with high expansion ratios and atraumatic ends
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