JP2011116787A5 - - Google Patents
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- JP2011116787A5 JP2011116787A5 JP2011057285A JP2011057285A JP2011116787A5 JP 2011116787 A5 JP2011116787 A5 JP 2011116787A5 JP 2011057285 A JP2011057285 A JP 2011057285A JP 2011057285 A JP2011057285 A JP 2011057285A JP 2011116787 A5 JP2011116787 A5 JP 2011116787A5
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- Prior art keywords
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- 239000000203 mixture Substances 0.000 claims 50
- 235000002639 sodium chloride Nutrition 0.000 claims 8
- 239000002840 nitric oxide donor Substances 0.000 claims 7
- 238000007665 sagging Methods 0.000 claims 7
- MWUXSHHQAYIFBG-UHFFFAOYSA-N Nitric oxide Chemical compound O=[N] MWUXSHHQAYIFBG-UHFFFAOYSA-N 0.000 claims 6
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims 6
- 150000003839 salts Chemical class 0.000 claims 6
- VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 claims 4
- TWRXJAOTZQYOKJ-UHFFFAOYSA-L Magnesium chloride Chemical compound [Mg+2].[Cl-].[Cl-] TWRXJAOTZQYOKJ-UHFFFAOYSA-L 0.000 claims 4
- WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 claims 4
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims 4
- 229940075529 glyceryl stearate Drugs 0.000 claims 4
- KWGKDLIKAYFUFQ-UHFFFAOYSA-M lithium chloride Chemical compound [Li+].[Cl-] KWGKDLIKAYFUFQ-UHFFFAOYSA-M 0.000 claims 4
- LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 claims 4
- QELSKZZBTMNZEB-UHFFFAOYSA-N propylparaben Chemical compound CCCOC(=O)C1=CC=C(O)C=C1 QELSKZZBTMNZEB-UHFFFAOYSA-N 0.000 claims 4
- ODKSFYDXXFIFQN-BYPYZUCNSA-N L-arginine Chemical compound OC(=O)[C@@H](N)CCCN=C(N)N ODKSFYDXXFIFQN-BYPYZUCNSA-N 0.000 claims 3
- 229930064664 L-arginine Natural products 0.000 claims 3
- 235000014852 L-arginine Nutrition 0.000 claims 3
- YYGNTYWPHWGJRM-UHFFFAOYSA-N (6E,10E,14E,18E)-2,6,10,15,19,23-hexamethyltetracosa-2,6,10,14,18,22-hexaene Chemical compound CC(C)=CCCC(C)=CCCC(C)=CCCC=C(C)CCC=C(C)CCC=C(C)C YYGNTYWPHWGJRM-UHFFFAOYSA-N 0.000 claims 2
- WRIDQFICGBMAFQ-UHFFFAOYSA-N (E)-8-Octadecenoic acid Natural products CCCCCCCCCC=CCCCCCCC(O)=O WRIDQFICGBMAFQ-UHFFFAOYSA-N 0.000 claims 2
- FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 claims 2
- FKOKUHFZNIUSLW-UHFFFAOYSA-N 2-Hydroxypropyl stearate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(C)O FKOKUHFZNIUSLW-UHFFFAOYSA-N 0.000 claims 2
- 239000001763 2-hydroxyethyl(trimethyl)azanium Substances 0.000 claims 2
- LQJBNNIYVWPHFW-UHFFFAOYSA-N 20:1omega9c fatty acid Natural products CCCCCCCCCCC=CCCCCCCCC(O)=O LQJBNNIYVWPHFW-UHFFFAOYSA-N 0.000 claims 2
- HIQIXEFWDLTDED-UHFFFAOYSA-N 4-hydroxy-1-piperidin-4-ylpyrrolidin-2-one Chemical compound O=C1CC(O)CN1C1CCNCC1 HIQIXEFWDLTDED-UHFFFAOYSA-N 0.000 claims 2
- QSBYPNXLFMSGKH-UHFFFAOYSA-N 9-Heptadecensaeure Natural products CCCCCCCC=CCCCCCCCC(O)=O QSBYPNXLFMSGKH-UHFFFAOYSA-N 0.000 claims 2
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 claims 2
- 235000019743 Choline chloride Nutrition 0.000 claims 2
- 102000008186 Collagen Human genes 0.000 claims 2
- 108010035532 Collagen Proteins 0.000 claims 2
- ZAKOWWREFLAJOT-CEFNRUSXSA-N D-alpha-tocopherylacetate Chemical compound CC(=O)OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-CEFNRUSXSA-N 0.000 claims 2
- IOVCWXUNBOPUCH-UHFFFAOYSA-M Nitrite anion Chemical compound [O-]N=O IOVCWXUNBOPUCH-UHFFFAOYSA-M 0.000 claims 2
- GWFGDXZQZYMSMJ-UHFFFAOYSA-N Octadecansaeure-heptadecylester Natural products CCCCCCCCCCCCCCCCCOC(=O)CCCCCCCCCCCCCCCCC GWFGDXZQZYMSMJ-UHFFFAOYSA-N 0.000 claims 2
- ZQPPMHVWECSIRJ-UHFFFAOYSA-N Oleic acid Natural products CCCCCCCCC=CCCCCCCCC(O)=O ZQPPMHVWECSIRJ-UHFFFAOYSA-N 0.000 claims 2
- 239000005642 Oleic acid Substances 0.000 claims 2
- 229920001214 Polysorbate 60 Polymers 0.000 claims 2
- HVUMOYIDDBPOLL-XWVZOOPGSA-N Sorbitan monostearate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O HVUMOYIDDBPOLL-XWVZOOPGSA-N 0.000 claims 2
- BHEOSNUKNHRBNM-UHFFFAOYSA-N Tetramethylsqualene Natural products CC(=C)C(C)CCC(=C)C(C)CCC(C)=CCCC=C(C)CCC(C)C(=C)CCC(C)C(C)=C BHEOSNUKNHRBNM-UHFFFAOYSA-N 0.000 claims 2
- GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical compound OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 claims 2
- FPIPGXGPPPQFEQ-BOOMUCAASA-N Vitamin A Natural products OC/C=C(/C)\C=C\C=C(\C)/C=C/C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-BOOMUCAASA-N 0.000 claims 2
- 229930003316 Vitamin D Natural products 0.000 claims 2
- QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 claims 2
- OIRDTQYFTABQOQ-KQYNXXCUSA-N adenosine Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O OIRDTQYFTABQOQ-KQYNXXCUSA-N 0.000 claims 2
- FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 claims 2
- 235000014104 aloe vera supplement Nutrition 0.000 claims 2
- 239000001110 calcium chloride Substances 0.000 claims 2
- 229910001628 calcium chloride Inorganic materials 0.000 claims 2
- 235000011148 calcium chloride Nutrition 0.000 claims 2
- SGMZJAMFUVOLNK-UHFFFAOYSA-M choline chloride Chemical compound [Cl-].C[N+](C)(C)CCO SGMZJAMFUVOLNK-UHFFFAOYSA-M 0.000 claims 2
- 229960003178 choline chloride Drugs 0.000 claims 2
- 229920001436 collagen Polymers 0.000 claims 2
- 229960005188 collagen Drugs 0.000 claims 2
- 239000006071 cream Substances 0.000 claims 2
- PRAKJMSDJKAYCZ-UHFFFAOYSA-N dodecahydrosqualene Natural products CC(C)CCCC(C)CCCC(C)CCCCC(C)CCCC(C)CCCC(C)C PRAKJMSDJKAYCZ-UHFFFAOYSA-N 0.000 claims 2
- ZCTXEAQXZGPWFG-UHFFFAOYSA-N imidurea Chemical compound O=C1NC(=O)N(CO)C1NC(=O)NCNC(=O)NC1C(=O)NC(=O)N1CO ZCTXEAQXZGPWFG-UHFFFAOYSA-N 0.000 claims 2
- QXJSBBXBKPUZAA-UHFFFAOYSA-N isooleic acid Natural products CCCCCCCC=CCCCCCCCCC(O)=O QXJSBBXBKPUZAA-UHFFFAOYSA-N 0.000 claims 2
- 229910001629 magnesium chloride Inorganic materials 0.000 claims 2
- 235000011147 magnesium chloride Nutrition 0.000 claims 2
- 235000010270 methyl p-hydroxybenzoate Nutrition 0.000 claims 2
- 239000004292 methyl p-hydroxybenzoate Substances 0.000 claims 2
- 229960002216 methylparaben Drugs 0.000 claims 2
- 239000002480 mineral oil Substances 0.000 claims 2
- 235000010446 mineral oil Nutrition 0.000 claims 2
- 229940042472 mineral oil Drugs 0.000 claims 2
- NKBWPOSQERPBFI-UHFFFAOYSA-N octadecyl octadecanoate Chemical compound CCCCCCCCCCCCCCCCCCOC(=O)CCCCCCCCCCCCCCCCC NKBWPOSQERPBFI-UHFFFAOYSA-N 0.000 claims 2
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 claims 2
- 229960002969 oleic acid Drugs 0.000 claims 2
- 235000021313 oleic acid Nutrition 0.000 claims 2
- 239000002357 osmotic agent Substances 0.000 claims 2
- KJFMBFZCATUALV-UHFFFAOYSA-N phenolphthalein Chemical compound C1=CC(O)=CC=C1C1(C=2C=CC(O)=CC=2)C2=CC=CC=C2C(=O)O1 KJFMBFZCATUALV-UHFFFAOYSA-N 0.000 claims 2
- 239000001818 polyoxyethylene sorbitan monostearate Substances 0.000 claims 2
- 235000010989 polyoxyethylene sorbitan monostearate Nutrition 0.000 claims 2
- 229940113124 polysorbate 60 Drugs 0.000 claims 2
- 239000001103 potassium chloride Substances 0.000 claims 2
- 235000011164 potassium chloride Nutrition 0.000 claims 2
- 235000010232 propyl p-hydroxybenzoate Nutrition 0.000 claims 2
- 239000004405 propyl p-hydroxybenzoate Substances 0.000 claims 2
- 229960004063 propylene glycol Drugs 0.000 claims 2
- 235000013772 propylene glycol Nutrition 0.000 claims 2
- 229960003415 propylparaben Drugs 0.000 claims 2
- 239000011780 sodium chloride Substances 0.000 claims 2
- 229950011392 sorbitan stearate Drugs 0.000 claims 2
- 229940031439 squalene Drugs 0.000 claims 2
- TUHBEKDERLKLEC-UHFFFAOYSA-N squalene Natural products CC(=CCCC(=CCCC(=CCCC=C(/C)CCC=C(/C)CC=C(C)C)C)C)C TUHBEKDERLKLEC-UHFFFAOYSA-N 0.000 claims 2
- 229940042585 tocopherol acetate Drugs 0.000 claims 2
- 229960004418 trolamine Drugs 0.000 claims 2
- 235000019155 vitamin A Nutrition 0.000 claims 2
- 239000011719 vitamin A Substances 0.000 claims 2
- 235000019166 vitamin D Nutrition 0.000 claims 2
- 239000011710 vitamin D Substances 0.000 claims 2
- 150000003710 vitamin D derivatives Chemical class 0.000 claims 2
- 229940045997 vitamin a Drugs 0.000 claims 2
- 229940046008 vitamin d Drugs 0.000 claims 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 2
- 239000010497 wheat germ oil Substances 0.000 claims 2
- KHOITXIGCFIULA-UHFFFAOYSA-N Alophen Chemical compound C1=CC(OC(=O)C)=CC=C1C(C=1N=CC=CC=1)C1=CC=C(OC(C)=O)C=C1 KHOITXIGCFIULA-UHFFFAOYSA-N 0.000 claims 1
- 101800004538 Bradykinin Proteins 0.000 claims 1
- 239000002126 C01EB10 - Adenosine Substances 0.000 claims 1
- 102000004082 Calreticulin Human genes 0.000 claims 1
- 108090000549 Calreticulin Proteins 0.000 claims 1
- 102000004127 Cytokines Human genes 0.000 claims 1
- 108090000695 Cytokines Proteins 0.000 claims 1
- 102000002045 Endothelin Human genes 0.000 claims 1
- 108050009340 Endothelin Proteins 0.000 claims 1
- QXZGBUJJYSLZLT-UHFFFAOYSA-N H-Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg-OH Natural products NC(N)=NCCCC(N)C(=O)N1CCCC1C(=O)N1C(C(=O)NCC(=O)NC(CC=2C=CC=CC=2)C(=O)NC(CO)C(=O)N2C(CCC2)C(=O)NC(CC=2C=CC=CC=2)C(=O)NC(CCCN=C(N)N)C(O)=O)CCC1 QXZGBUJJYSLZLT-UHFFFAOYSA-N 0.000 claims 1
- 102100035792 Kininogen-1 Human genes 0.000 claims 1
- -1 N-nitroso-N-substituted hydroxylamine Chemical class 0.000 claims 1
- 210000001015 abdomen Anatomy 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 229960005305 adenosine Drugs 0.000 claims 1
- 210000000544 articulatio talocruralis Anatomy 0.000 claims 1
- 230000015572 biosynthetic process Effects 0.000 claims 1
- 229960000503 bisacodyl Drugs 0.000 claims 1
- QXZGBUJJYSLZLT-FDISYFBBSA-N bradykinin Chemical compound NC(=N)NCCC[C@H](N)C(=O)N1CCC[C@H]1C(=O)N1[C@H](C(=O)NCC(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CO)C(=O)N2[C@@H](CCC2)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)CCC1 QXZGBUJJYSLZLT-FDISYFBBSA-N 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- ZUBDGKVDJUIMQQ-UBFCDGJISA-N endothelin-1 Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(O)=O)NC(=O)[C@H]1NC(=O)[C@H](CC=2C=CC=CC=2)NC(=O)[C@@H](CC=2C=CC(O)=CC=2)NC(=O)[C@H](C(C)C)NC(=O)[C@H]2CSSC[C@@H](C(N[C@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@H](CC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N2)=O)NC(=O)[C@@H](CO)NC(=O)[C@H](N)CSSC1)C1=CNC=N1 ZUBDGKVDJUIMQQ-UBFCDGJISA-N 0.000 claims 1
- 210000001061 forehead Anatomy 0.000 claims 1
- 150000004676 glycans Chemical class 0.000 claims 1
- YAYBWZFZDMHVDH-UHFFFAOYSA-N n-amino-n-hydroxynitrous amide Chemical compound NN(O)N=O YAYBWZFZDMHVDH-UHFFFAOYSA-N 0.000 claims 1
- 239000012038 nucleophile Substances 0.000 claims 1
- 229920001282 polysaccharide Polymers 0.000 claims 1
- 239000005017 polysaccharide Substances 0.000 claims 1
- 239000000758 substrate Substances 0.000 claims 1
- 238000003786 synthesis reaction Methods 0.000 claims 1
- 125000003396 thiol group Chemical group [H]S* 0.000 claims 1
- ICRHORQIUXBEPA-UHFFFAOYSA-N thionitrous acid Chemical compound SN=O ICRHORQIUXBEPA-UHFFFAOYSA-N 0.000 claims 1
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US54621404P | 2004-02-23 | 2004-02-23 | |
| US60/546,214 | 2004-02-23 | ||
| US56356604P | 2004-04-19 | 2004-04-19 | |
| US60/563,566 | 2004-04-19 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006554318A Division JP5376761B2 (ja) | 2004-02-23 | 2005-02-23 | 身体の外観および皮膚の外観を改善するための、一酸化窒素の局所送達 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012053145A Division JP2012107071A (ja) | 2004-02-23 | 2012-03-09 | 身体の外観および皮膚の外観を改善するための、一酸化窒素の局所送達 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2011116787A JP2011116787A (ja) | 2011-06-16 |
| JP2011116787A5 true JP2011116787A5 (enExample) | 2012-05-10 |
Family
ID=34915567
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006554318A Expired - Fee Related JP5376761B2 (ja) | 2004-02-23 | 2005-02-23 | 身体の外観および皮膚の外観を改善するための、一酸化窒素の局所送達 |
| JP2011057285A Pending JP2011116787A (ja) | 2004-02-23 | 2011-03-15 | 身体の外観および皮膚の外観を改善するための、一酸化窒素の局所送達 |
| JP2012053145A Withdrawn JP2012107071A (ja) | 2004-02-23 | 2012-03-09 | 身体の外観および皮膚の外観を改善するための、一酸化窒素の局所送達 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006554318A Expired - Fee Related JP5376761B2 (ja) | 2004-02-23 | 2005-02-23 | 身体の外観および皮膚の外観を改善するための、一酸化窒素の局所送達 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012053145A Withdrawn JP2012107071A (ja) | 2004-02-23 | 2012-03-09 | 身体の外観および皮膚の外観を改善するための、一酸化窒素の局所送達 |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US20080045909A1 (enExample) |
| EP (1) | EP1732577B1 (enExample) |
| JP (3) | JP5376761B2 (enExample) |
| AU (2) | AU2005216192B2 (enExample) |
| CA (1) | CA2556967A1 (enExample) |
| ES (1) | ES2421142T3 (enExample) |
| WO (1) | WO2005081964A2 (enExample) |
Families Citing this family (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7914814B2 (en) | 1997-09-17 | 2011-03-29 | Strategic Science & Technologies, Llc | Topical delivery of arginine of cause beneficial effects |
| US7629384B2 (en) * | 1997-09-17 | 2009-12-08 | Strategic Science & Technologies, Llc | Topical delivery of L-arginine to cause beneficial effects |
| AU2005216192B2 (en) * | 2004-02-23 | 2010-11-04 | Strategic Science & Technologies, Llc | Topical delivery of a nitric oxide donor to improve body and skin appearance |
| EP1737429B1 (en) | 2004-04-19 | 2013-07-17 | Strategic Science & Technologies, LLC | Transdermal delivery of beneficial substances effected by a high ionic strength environment |
| US20110028548A1 (en) * | 2004-04-19 | 2011-02-03 | Strategic Science & Technologies, Llc | Beneficial effects of increasing local blood flow |
| US9226909B2 (en) | 2004-04-19 | 2016-01-05 | Strategic Science & Technologies, Llc | Beneficial effects of increasing local blood flow |
| HUP0401422A2 (en) * | 2004-07-15 | 2006-04-28 | G Laszlo Meszaros | Use of l-arginine as vasoaktive ingredient absorbing through skin for external application |
| EP1888510A4 (en) | 2005-05-27 | 2013-01-16 | Univ North Carolina | NITROGEN OXIDE-RELATED PARTICLES FOR NITROGEN OXIDE THERAPEUTICS AND BIOMEDICAL APPLICATIONS |
| KR20100021564A (ko) * | 2007-03-27 | 2010-02-25 | 노랩스 에이비 | 산화 질소 전달을 위한 국소 피부 전달 장치 |
| ITBS20070177A1 (it) * | 2007-11-15 | 2009-05-16 | Paoli Ambrosi Gianfranco De | Composizione per uso topico per ottenere un rapido ed intenso effetto lifting |
| WO2010044875A2 (en) * | 2008-10-16 | 2010-04-22 | Novan, Inc. | Nitric oxide releasing particles for oral care applications |
| US11684624B2 (en) | 2009-06-24 | 2023-06-27 | Strategic Science & Technologies, Llc | Treatment of erectile dysfunction and other indications |
| US12138268B2 (en) | 2009-06-24 | 2024-11-12 | Strategic Science & Technologies, Llc | Treatment of erectile dysfunction and other indications |
| US9463158B2 (en) | 2009-06-24 | 2016-10-11 | Strategic Science & Technologies, Llc | Treatment of erectile dysfunction and other indications |
| EP2445493A1 (en) | 2009-06-24 | 2012-05-02 | Strategic Science & Technologies, LLC | Topical composition containing naproxen |
| CN102481275B (zh) | 2009-06-24 | 2014-07-23 | 战略科学技术有限公司 | 含有布洛芬的表面组合物 |
| BR112012003792B1 (pt) | 2009-08-21 | 2020-05-19 | Novan Inc | composição tópica, e, uso da composição tópica |
| BR112012003804B1 (pt) | 2009-08-21 | 2019-02-19 | Novan, Inc. | Curativo para ferimentos, método para formar um curativo para ferimentos, e, kit de curativo para ferimento |
| BR112012008508A2 (pt) * | 2009-10-13 | 2017-06-13 | Novan Inc | revestimento de sol-gel, substrato, método para produzir um revestimento de sol-gel |
| EP2582382B1 (en) * | 2010-06-17 | 2017-04-19 | New York University | Cosmetic uses and applications of calreticulin |
| WO2012027827A1 (en) * | 2010-08-30 | 2012-03-08 | Oral Delivery Technology Ltd. | Nitric oxide amino acid esters for skin rejuvenation |
| US8591876B2 (en) | 2010-12-15 | 2013-11-26 | Novan, Inc. | Methods of decreasing sebum production in the skin |
| US9289495B2 (en) | 2010-12-29 | 2016-03-22 | Strategic Science & Technologies, Llc | Systems and methods for treatment of allergies and other indications |
| WO2012093643A1 (ja) * | 2011-01-05 | 2012-07-12 | 花王株式会社 | 化粧料 |
| ES2695173T3 (es) | 2011-02-28 | 2019-01-02 | Novan Inc | Partículas de sílice modificadas con S-nitrosotiol que liberan óxido nítrico y procedimientos de fabricación de las mismas |
| US10202338B2 (en) | 2011-06-21 | 2019-02-12 | Evologie Llc | Topical compositions for the treatment of dermatological disorders |
| WO2013159140A1 (en) * | 2012-04-26 | 2013-10-31 | Edser Brenden | Eds005 skin cancer cream |
| US20160081915A1 (en) | 2013-03-15 | 2016-03-24 | Strategic Science & Technologies, Llc | Transdermal formulations of fluticasone |
| EP2968130A1 (en) | 2013-03-15 | 2016-01-20 | Strategic Science & Technologies, LLC | Transdermal delivery of sildenafil and other phosphodiesterase type 5 inhibitors |
| US10517817B2 (en) | 2013-05-09 | 2019-12-31 | Syk Technologies, Llc | Deep topical systemic nitric oxide therapy apparatus and method |
| WO2016112201A1 (en) | 2015-01-07 | 2016-07-14 | Strategic Science & Technologies, Llc | Techniques and systems for transdermal delivery involving treatment of psoriasis, skin cancer, and other indications |
| US10688069B2 (en) | 2016-03-31 | 2020-06-23 | REV Pharmaceuticals LLC | Sports health performance composition |
| CN108785287B (zh) | 2017-04-28 | 2021-09-24 | 日东电工株式会社 | 透皮吸收制剂前体 |
| US20200368353A1 (en) * | 2017-11-27 | 2020-11-26 | Innovus Pharmaceuticals, Inc. | Systems and methods for topical creams for warming |
| TW201927292A (zh) | 2017-12-13 | 2019-07-16 | 大陸商上海小午醫藥科技有限公司 | 一種用於預防或治療與ｅｇｆｒ被抑制相關疾病的方法 |
| WO2019169092A1 (en) | 2018-03-01 | 2019-09-06 | The Regents Of The University Of Michigan | Two-part nitric oxide generating topical compositions |
| AU2019254237B2 (en) | 2018-04-16 | 2025-01-30 | Onquality Pharmaceuticals China Ltd. | Method for preventing or treating side effects of cancer therapy |
| CN108619061A (zh) * | 2018-07-11 | 2018-10-09 | 广东泓睿科技有限公司 | 一种丰胸乳液及其制备方法 |
| FR3083981B1 (fr) * | 2018-07-20 | 2021-01-15 | Semiocare Sas | Compositions a usage cosmetique et dermatologique |
| US20210000910A1 (en) | 2019-07-03 | 2021-01-07 | Jysk Skin Solutions Pte Ltd | Topical compositions |
| JP2023532085A (ja) | 2020-06-30 | 2023-07-26 | ビレオ システムズ インコーポレイテッド | 膣感染症を治療するための組成物及び方法 |
| CN116685302A (zh) * | 2021-01-15 | 2023-09-01 | 利勒格有限公司 | 局部组合物 |
| EP4277592A4 (en) * | 2021-01-15 | 2024-12-11 | Liliger Ltd | TOPICAL COMPOSITION |
| US12083204B2 (en) | 2022-06-02 | 2024-09-10 | L'oreal | Topical composition for homeostatic delivery of nitric oxide and uses thereof |
| CN116496436B (zh) * | 2023-04-28 | 2024-07-05 | 西安理工大学 | 多氢键网络基自修复高透明导电弹性体的制备方法及应用 |
| MX2024012712A (es) * | 2023-10-24 | 2025-05-02 | Albert Einstein College Medicine | Formulaciones de administracion transdermica. |
Family Cites Families (127)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR1553063A (enExample) * | 1967-11-28 | 1969-01-10 | ||
| US3960782A (en) * | 1974-09-27 | 1976-06-01 | The Procter & Gamble Company | Shampoo compositions which impart high luster and manageability to hair |
| US4185100A (en) * | 1976-05-13 | 1980-01-22 | Johnson & Johnson | Topical anti-inflammatory drug therapy |
| FR2557452B1 (fr) * | 1983-12-28 | 1986-08-14 | Roussel Uclaf | Nouvelles compositions pour les soins de la peau renfermant de l'huile d'onagre et des traits tissulaires de rate |
| US4681897A (en) * | 1984-01-16 | 1987-07-21 | The Procter & Gamble Company | Pharmaceutical products providing enhanced analgesia |
| US4722837A (en) * | 1984-05-29 | 1988-02-02 | Derma-Cure, Inc. | Medicated shampoo composition |
| US4732892A (en) * | 1985-07-12 | 1988-03-22 | American Home Products Corporation | L-α-amino acids as transdermal penetration enhancers |
| EP0226332B1 (en) * | 1985-11-18 | 1992-03-25 | Beecham Group Plc | Veterinary compositions |
| GB8606368D0 (en) * | 1986-03-14 | 1986-04-23 | Unilever Plc | Skin treatment composition |
| US4885157A (en) * | 1987-02-13 | 1989-12-05 | Fiaschetti Mary G | Dermal cosmetic composition and applications therefor |
| US5925372A (en) * | 1987-12-16 | 1999-07-20 | Novartis Corporation | Mixed solvent mutually enhanced transdermal therapeutic system |
| US4871718A (en) * | 1987-12-29 | 1989-10-03 | Raymond A. Roncari | Composition of matter for increasing intracellular ATP levels and physical performance levels and for increasing the rate of wound repair |
| DE3827362A1 (de) * | 1988-08-12 | 1990-02-15 | Basf Ag | Pulvrige, hydrophile theophyllinformulierung und verfahren zur ihrer herstellung |
| EP0406347A4 (en) * | 1988-09-30 | 1991-04-03 | Kazuo Watanabe | Anti-inflammatory and analgesic compounds, related compositions and methods for preparation and use thereof |
| US4945901A (en) * | 1989-03-22 | 1990-08-07 | Burcke Jr Harry J | Hand therapy apparatus and method therefor |
| US5158761A (en) * | 1989-04-05 | 1992-10-27 | Toko Yakuhin Kogyo Kabushiki Kaisha | Spray gel base and spray gel preparation using thereof |
| US5476852A (en) * | 1989-05-03 | 1995-12-19 | Janssen Pharmaceutica N.V. | Method of topically treating acne vulgaris, hyperkeratotic dermatoses, and photo-aging of the skin |
| US5028435A (en) * | 1989-05-22 | 1991-07-02 | Advanced Polymer Systems, Inc. | System and method for transdermal drug delivery |
| JP2761939B2 (ja) * | 1989-09-04 | 1998-06-04 | 株式会社コーセー | 水中油型乳化化粧料 |
| US5576351A (en) * | 1989-12-29 | 1996-11-19 | Mcgaw, Inc. | Use of arginine as an immunostimulator |
| EP0441119A3 (en) * | 1990-01-09 | 1992-10-14 | Richard D. Levere | The use of l-arginine in the treatment of hypertension and other vascular disorders |
| US5332758A (en) * | 1990-07-13 | 1994-07-26 | Kanebo, Ltd. | Collagen metabolism ameliorant and its use |
| US5824658A (en) * | 1990-09-18 | 1998-10-20 | Hyal Pharmaceutical Corporation | Topical composition containing hyaluronic acid and NSAIDS |
| DE4100975A1 (de) * | 1991-01-15 | 1992-07-16 | Weuffen Wolfgang | Kosmetische oder pharmazeutische zubereitungen zur verbesserung der haarqualitaet und foerderung des haarwachstums |
| US5210099A (en) * | 1991-02-11 | 1993-05-11 | American Home Products Corporation | Analgesic compositions |
| JPH06509060A (ja) * | 1991-03-01 | 1994-10-13 | アーサートン・インベストメンツ・リミテッド | 皮膚を処置するための治療用および化粧用組成物 |
| ATE157009T1 (de) * | 1991-03-01 | 1997-09-15 | Atherton Investments Ltd | Therapeutische und kosmetische zusammensetzungen zur hautbehandlung |
| US5498420A (en) * | 1991-04-12 | 1996-03-12 | Merz & Co. Gmbh & Co. | Stable small particle liposome preparations, their production and use in topical cosmetic, and pharmaceutical compositions |
| JP2636118B2 (ja) * | 1991-09-10 | 1997-07-30 | 三省製薬株式会社 | 育毛剤 |
| US5254331A (en) * | 1991-09-12 | 1993-10-19 | Chanel, Inc. | Skin cream composition |
| US5215759A (en) * | 1991-10-01 | 1993-06-01 | Chanel, Inc. | Cosmetic composition |
| US5217652A (en) * | 1991-10-04 | 1993-06-08 | The Gillette Company | Conditioning shampoo |
| ATE169826T1 (de) * | 1992-01-21 | 1998-09-15 | Macrochem Corp | Iontophoretische verbesserte verabreichung von medikamenten |
| US5405919A (en) * | 1992-08-24 | 1995-04-11 | The United States Of America As Represented By The Secretary Of Health And Human Services | Polymer-bound nitric oxide/nucleophile adduct compositions, pharmaceutical compositions and methods of treating biological disorders |
| US5632981A (en) * | 1992-08-24 | 1997-05-27 | The United States Of America As Represented By The Department Of Health And Human Services | Biopolymer-bound nitric oxide-releasing compositions, pharmaceutical compositions incorporating same and methods of treating biological disorders using same |
| US5691423A (en) * | 1992-08-24 | 1997-11-25 | The United States Of America As Represented By The Department Of Health And Human Services | Polysaccharide-bound nitric oxide-nucleophile adducts |
| KR100271225B1 (ko) * | 1992-08-31 | 2000-11-01 | 후나키 토시유키 | 안전스위치장치 |
| US5439938A (en) * | 1993-04-07 | 1995-08-08 | The Johns Hopkins University | Treatments for male sexual dysfunction |
| US5891459A (en) * | 1993-06-11 | 1999-04-06 | The Board Of Trustees Of The Leland Stanford Junior University | Enhancement of vascular function by modulation of endogenous nitric oxide production or activity |
| US5428070A (en) * | 1993-06-11 | 1995-06-27 | The Board Of Trustees Of The Leland Stanford Junior University | Treatment of vascular degenerative diseases by modulation of endogenous nitric oxide production of activity |
| US5714472A (en) * | 1993-12-23 | 1998-02-03 | Nestec Ltd. | Enternal formulation designed for optimized nutrient absorption and wound healing |
| GB9409281D0 (en) * | 1994-05-10 | 1994-06-29 | Svedman Paul | Transdermal device |
| US5543430A (en) * | 1994-10-05 | 1996-08-06 | Kaesemeyer; W. H. | Method and formulation of stimulating nitric oxide synthesis |
| US5505958A (en) * | 1994-10-31 | 1996-04-09 | Algos Pharmaceutical Corporation | Transdermal drug delivery device and method for its manufacture |
| WO1996014083A1 (de) * | 1994-11-04 | 1996-05-17 | Polymun Scientific Immunbiologische Forschung Gmbh | Applikation von sod in liposomen |
| US5648101A (en) * | 1994-11-14 | 1997-07-15 | Tawashi; Rashad | Drug delivery of nitric oxide |
| US5562917A (en) * | 1994-12-23 | 1996-10-08 | Pentech Pharmaceuticals, Inc. | Transdermal administration of apomorphine |
| US5595753A (en) * | 1995-04-14 | 1997-01-21 | President And Fellows Of Harvard College | Topical formulations and methods for treating hemorrhoidal pain and sphincter and smooth muscle spasm in the gastrointestinal tract |
| US5643586A (en) * | 1995-04-27 | 1997-07-01 | Perricone; Nicholas V. | Topical compositions and methods for treatment of skin damage and aging using catecholamines and related compounds |
| US5762963A (en) * | 1995-06-07 | 1998-06-09 | Emory University | Method and compositions for controlling oral and pharyngeal pain using capsaicinoids |
| US5645859A (en) * | 1995-10-02 | 1997-07-08 | Isp Investments Inc. | Process for producing an alpha or beta-hydroxy acid-vinylpyrrolidone polymer, copolymer or graft polymer complex in the form of free-flowing powders having a high acid loading |
| US5605685A (en) * | 1995-09-13 | 1997-02-25 | Isp Investments Inc. | Non-irritating skin and hair rejuvenating compostion having a pH between 1 and 6.5 |
| US6036977A (en) * | 1995-09-29 | 2000-03-14 | L.A.M. Pharmaceutical Corp. | Drug preparations for treating sexual dysfunction |
| FR2740339B1 (fr) * | 1995-10-26 | 1997-12-05 | Oreal | Utilisation d'au moins un inhibiteur de no-synthase dans le traitement des peaux sensibles |
| US5716436B1 (en) * | 1995-11-30 | 1999-08-24 | Eastman Kodak Co | Ink jet containing polyester ionomers |
| US5789442A (en) * | 1996-01-18 | 1998-08-04 | Schering Aktiengesellschaft | Treatment of urinary incontinence with nitric oxide synthase substrates and/or nitric oxide donors alone or in combination with estrogen or progesterone and/or other agents |
| GB9608408D0 (en) * | 1996-04-23 | 1996-06-26 | Adams Michael A | Treatment of erectile dysfunction |
| US5911980A (en) * | 1996-06-27 | 1999-06-15 | Macrochem Corporation | Lipophilic and amphiphilic or hydrophilic film-forming polymer compositions, and use thereof in topical agent delivery system and method of delivering agents to the skin |
| US20020015713A1 (en) * | 1996-10-24 | 2002-02-07 | Murdock Robert W. | Methods and transdermal compositions for pain relief |
| US5891472A (en) * | 1996-11-19 | 1999-04-06 | Meri Charmyne Russell | Treatment of equine laminitis |
| JPH10167953A (ja) * | 1996-12-06 | 1998-06-23 | Daicel Chem Ind Ltd | 化粧品組成物 |
| US5807957A (en) * | 1996-12-23 | 1998-09-15 | Macrochem Corporation | Cationic film-forming polymer compositions, and use thereof in topical agents delivery system and method of delivering agents to the skin |
| IL120531A (en) * | 1997-03-26 | 2006-12-31 | Yissum Res Dev Co | Nitric oxide donors and pharmaceutical compositions containing them |
| FR2762782B1 (fr) * | 1997-05-05 | 1999-06-11 | Oreal | Composition comprenant un milieu de culture de micro-organisme et utilisation |
| JP4856295B2 (ja) * | 1997-07-03 | 2012-01-18 | アメリカ合衆国政府 | 新規な一酸化窒素放出アミジン誘導ジアゼニウムジオレート及びその組成物 |
| US5976566A (en) * | 1997-08-29 | 1999-11-02 | Macrochem Corporation | Non-steroidal antiinflammtory drug formulations for topical application to the skin |
| US7629384B2 (en) * | 1997-09-17 | 2009-12-08 | Strategic Science & Technologies, Llc | Topical delivery of L-arginine to cause beneficial effects |
| US5895658A (en) * | 1997-09-17 | 1999-04-20 | Fossel; Eric T. | Topical delivery of L-arginine to cause tissue warming |
| US7914814B2 (en) * | 1997-09-17 | 2011-03-29 | Strategic Science & Technologies, Llc | Topical delivery of arginine of cause beneficial effects |
| US6207713B1 (en) * | 1997-09-17 | 2001-03-27 | Eric T. Fossel | Topical and oral delivery of arginine to cause beneficial effects |
| WO1999013717A1 (en) * | 1997-09-17 | 1999-03-25 | Strategic Science & Technologies, Inc. | A delivery of arginine to cause beneficial effects |
| US5922332A (en) * | 1997-09-17 | 1999-07-13 | Fossel; Eric T. | Topical delivery of arginine to overcome pain |
| US6096759A (en) * | 1997-09-19 | 2000-08-01 | Georgetown University | Method for treating essential hypertension |
| US5906822A (en) * | 1997-09-25 | 1999-05-25 | Macrochem Corporation | Cationic film-forming polymer compositions, and use thereof in topical agents delivery system and method of delivering agents to the skin |
| JP2003525843A (ja) * | 1997-10-08 | 2003-09-02 | ジェネシスコスメティックス ライツ アンド ライセンシズ カンパニー リミテッド | 脂肪細胞を含む身体部位の引き締めおよび／または縮小 |
| US6031888A (en) * | 1997-11-26 | 2000-02-29 | Picker International, Inc. | Fluoro-assist feature for a diagnostic imaging device |
| GB9801398D0 (en) * | 1998-01-22 | 1998-03-18 | Anggard Erik E | Chemical compounds |
| KR20010043866A (ko) * | 1998-06-01 | 2001-05-25 | 안쏘니 제이. 버비스카 | 국소용 경피 치료제 |
| US6103275A (en) * | 1998-06-10 | 2000-08-15 | Nitric Oxide Solutions | Systems and methods for topical treatment with nitric oxide |
| US6117872A (en) * | 1998-06-23 | 2000-09-12 | The Board Of Trustees Of The Leland Stanford Junior University | Enhancement of exercise performance by augmenting endogenous nitric oxide production or activity |
| MXPA00012844A (es) * | 1998-07-07 | 2004-05-21 | Transdermal Technologies Inc | Composiciones para la liberacion transdermica rapida y sin irritacion de agentes farmaceuticamente activos y metodos para formular tales composiciones y liberar los mismos. |
| DE19830649C2 (de) * | 1998-07-09 | 2003-04-10 | Lohmann Therapie Syst Lts | Topisches Pflaster mit nichtsteroidalen Antirheumatika mit Säuregruppe |
| DE19831798A1 (de) * | 1998-07-15 | 2000-01-27 | Mandorlo Investment Gmbh Luxem | Mittel zur Pflege und/oder Behandlung von Haut und Gewebe |
| WO2000024365A1 (en) * | 1998-10-26 | 2000-05-04 | University Of Massachusetts | Treatment of skin with adenosine or adenosine analog |
| US6261594B1 (en) * | 1998-11-25 | 2001-07-17 | The University Of Akron | Chitosan-based nitric oxide donor compositions |
| JP2000186028A (ja) * | 1998-12-21 | 2000-07-04 | Nobuko Koga | 化粧品 |
| FR2787996B1 (fr) * | 1998-12-30 | 2002-05-10 | Dior Christian Parfums | Composition cosmetique ou dermatologique contenant un actif stimulant la synthese de la proteine hsp 32 dans la peau et methode de traitement cosmetique |
| EP1161306B1 (en) * | 1999-03-12 | 2006-07-26 | Mystic Tan, Inc. | Misting apparatus for application of coating materials to skin surface |
| US6375672B1 (en) * | 1999-03-22 | 2002-04-23 | Board Of Trustees Of Michigan State University | Method for controlling the chemical and heat induced responses of collagenous materials |
| FR2794974B1 (fr) * | 1999-06-16 | 2001-08-17 | Exsymol Sa | Composition cosmetique pour l'amincissement a base de l-arginine, d'un analogue de l-arginine ou d'un de leurs derives, applicable par voie topique |
| CA2384080C (en) * | 1999-09-07 | 2012-03-20 | Kabushiki Kaisha Soken | Skin conditioner |
| US6562370B2 (en) * | 1999-12-16 | 2003-05-13 | Dermatrends, Inc. | Transdermal administration of steroid drugs using hydroxide-releasing agents as permeation enhancers |
| US6602912B2 (en) * | 2000-06-30 | 2003-08-05 | Dermatrends, Inc. | Transdermal administration of phenylpropanolamine |
| US6582724B2 (en) * | 1999-12-16 | 2003-06-24 | Dermatrends, Inc. | Dual enhancer composition for topical and transdermal drug delivery |
| US6586000B2 (en) * | 1999-12-16 | 2003-07-01 | Dermatrends, Inc. | Hydroxide-releasing agents as skin permeation enhancers |
| US6719997B2 (en) * | 2000-06-30 | 2004-04-13 | Dermatrends, Inc. | Transdermal administration of pharmacologically active amines using hydroxide-releasing agents as permeation enhancers |
| US6558695B2 (en) * | 1999-12-16 | 2003-05-06 | Dermatrends, Inc. | Topical and transdermal administration of peptidyl drugs using hydroxide releasing agents as permeation enhancers |
| US6565879B1 (en) * | 1999-12-16 | 2003-05-20 | Dermatrends, Inc. | Topical and transdermal administration of peptidyl drugs with hydroxide-releasing agents as skin permeation enhancers |
| FR2802414B1 (fr) * | 1999-12-20 | 2003-06-27 | G Pharm Lab | Composition, notamment cosmetique ou dermatologique, contenant des oligosaccharides, son procede de preparation et un procede de traitement cosmetique |
| JP2001288068A (ja) * | 2000-04-06 | 2001-10-16 | Nof Corp | 皮膚化粧料 |
| FR2810540B1 (fr) * | 2000-06-21 | 2004-04-30 | C3D | Nouvelles preparations cosmetiques ou hygieniques sous forme de dispersion |
| JP2002003373A (ja) * | 2000-06-27 | 2002-01-09 | Shiseido Co Ltd | 皮膚外用剤 |
| US6538033B2 (en) * | 2000-08-29 | 2003-03-25 | Huntington Medical Research Institutes | Nitric oxide donor compounds |
| JP2004520388A (ja) * | 2001-01-25 | 2004-07-08 | ザ ジェネラル ホスピタル コーポレーション | しわを治療するためのｎｏｓ阻害剤 |
| WO2002087700A1 (en) * | 2001-04-26 | 2002-11-07 | The Procter & Gamble Company | Method, kit and device for the treatment of cosmetic skin conditions |
| DE10128910A1 (de) * | 2001-06-15 | 2002-12-19 | Beiersdorf Ag | Verwendung von Wirkstoffkombinationen aus Arginin und Ascorbinsäure zur Hautstraffung |
| US20030157185A1 (en) * | 2002-02-08 | 2003-08-21 | Lou Paradise | Topical treatment of neuropathy |
| WO2003072039A2 (en) * | 2002-02-22 | 2003-09-04 | Essentia Biosystems, Inc. | Cosmetic formulations containing l-arginine oligomers |
| JP2003286129A (ja) * | 2002-03-27 | 2003-10-07 | Hakugen:Kk | 痩身シート材 |
| US20020168424A1 (en) * | 2002-07-31 | 2002-11-14 | Dr. Mohsen Shahinpoor | Nitric oxide (NO) donor+cGMP-PDE5 inhibitor as a topical drug for glaucoma |
| US7241456B2 (en) * | 2002-10-25 | 2007-07-10 | Australian Importers Ltd. | Formulations for topical delivery of bioactive substances and methods for their use |
| AU2003903037A0 (en) * | 2003-06-17 | 2003-07-03 | Institute Of Nutraceutical Research | Connective tissue derived polypeptides |
| WO2004112723A2 (en) * | 2003-06-20 | 2004-12-29 | Ronald Aung-Din | Tropical therapy for the treatment of migraines, muscle sprains, muscle spasm, spasticity and related conditions |
| US20050069590A1 (en) * | 2003-09-30 | 2005-03-31 | Buehler Gail K. | Stable suspensions for medicinal dosages |
| JP2005200370A (ja) * | 2004-01-16 | 2005-07-28 | Nikko Chemical Co Ltd | 一酸化窒素産生促進剤およびその利用 |
| AU2005216192B2 (en) * | 2004-02-23 | 2010-11-04 | Strategic Science & Technologies, Llc | Topical delivery of a nitric oxide donor to improve body and skin appearance |
| US20110028548A1 (en) * | 2004-04-19 | 2011-02-03 | Strategic Science & Technologies, Llc | Beneficial effects of increasing local blood flow |
| EP1737429B1 (en) * | 2004-04-19 | 2013-07-17 | Strategic Science & Technologies, LLC | Transdermal delivery of beneficial substances effected by a high ionic strength environment |
| US20090105336A1 (en) * | 2004-04-19 | 2009-04-23 | Strategic Science & Technologies, Llc | Beneficial Effects of Increasing Local Blood Flow |
| US20070087977A1 (en) * | 2004-11-16 | 2007-04-19 | Wendye Robbins | Methods and compositions for treating pain |
| US7442690B2 (en) * | 2005-03-14 | 2008-10-28 | P & L Enterprise Llc | Topical treatment for psoriasis |
| EP1770086A1 (de) * | 2005-09-29 | 2007-04-04 | Boehringer Ingelheim Pharma GmbH & Co. KG | Ausgewählte CGRP-Antagonisten, Verfahren zu deren Herstellung sowie deren Verwendung als Arzneimittel |
| MX363435B (es) * | 2007-03-22 | 2019-03-22 | Berg Llc | Formulaciones topicas que tienen biodisponibilidad aumentada. |
| US8686040B2 (en) * | 2008-03-31 | 2014-04-01 | Rdd Pharma Ltd. | Method for treating anal pruritis and other perianal disorders |
| US8969081B2 (en) * | 2008-12-10 | 2015-03-03 | The Trustees Of Columbia University In The City Of New York | Caudal motor neuron derived from embryonic stem cells under conditions essentially free of any retinoid |
| CN102481275B (zh) * | 2009-06-24 | 2014-07-23 | 战略科学技术有限公司 | 含有布洛芬的表面组合物 |
| EP2445493A1 (en) * | 2009-06-24 | 2012-05-02 | Strategic Science & Technologies, LLC | Topical composition containing naproxen |
-
2005
- 2005-02-23 AU AU2005216192A patent/AU2005216192B2/en not_active Ceased
- 2005-02-23 EP EP05723558.2A patent/EP1732577B1/en not_active Expired - Lifetime
- 2005-02-23 WO PCT/US2005/005726 patent/WO2005081964A2/en not_active Ceased
- 2005-02-23 US US10/590,300 patent/US20080045909A1/en not_active Abandoned
- 2005-02-23 JP JP2006554318A patent/JP5376761B2/ja not_active Expired - Fee Related
- 2005-02-23 CA CA002556967A patent/CA2556967A1/en not_active Abandoned
- 2005-02-23 ES ES05723558T patent/ES2421142T3/es not_active Expired - Lifetime
-
2010
- 2010-04-15 US US12/761,034 patent/US20100196517A1/en not_active Abandoned
-
2011
- 2011-01-19 AU AU2011200202A patent/AU2011200202B2/en not_active Ceased
- 2011-03-15 JP JP2011057285A patent/JP2011116787A/ja active Pending
-
2012
- 2012-03-09 JP JP2012053145A patent/JP2012107071A/ja not_active Withdrawn
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