CA2556967A1 - Topical delivery of a nitric oxide donor to improve body and skin appearance - Google Patents
Topical delivery of a nitric oxide donor to improve body and skin appearance Download PDFInfo
- Publication number
- CA2556967A1 CA2556967A1 CA002556967A CA2556967A CA2556967A1 CA 2556967 A1 CA2556967 A1 CA 2556967A1 CA 002556967 A CA002556967 A CA 002556967A CA 2556967 A CA2556967 A CA 2556967A CA 2556967 A1 CA2556967 A1 CA 2556967A1
- Authority
- CA
- Canada
- Prior art keywords
- nitric oxide
- skin
- delivery vehicle
- oxide donor
- arginine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 239000002840 nitric oxide donor Substances 0.000 title claims abstract description 80
- 230000037075 skin appearance Effects 0.000 title abstract description 11
- 230000000699 topical effect Effects 0.000 title description 14
- 239000006071 cream Substances 0.000 claims abstract description 41
- ODKSFYDXXFIFQN-BYPYZUCNSA-N L-arginine Chemical compound OC(=O)[C@@H](N)CCCN=C(N)N ODKSFYDXXFIFQN-BYPYZUCNSA-N 0.000 claims abstract description 38
- 229930064664 L-arginine Natural products 0.000 claims abstract description 38
- 235000014852 L-arginine Nutrition 0.000 claims abstract description 38
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- 239000003795 chemical substances by application Substances 0.000 claims abstract description 27
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- 239000001763 2-hydroxyethyl(trimethyl)azanium Substances 0.000 claims abstract description 10
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- 229960003178 choline chloride Drugs 0.000 claims abstract description 10
- MWUXSHHQAYIFBG-UHFFFAOYSA-N Nitric oxide Chemical compound O=[N] MWUXSHHQAYIFBG-UHFFFAOYSA-N 0.000 claims description 97
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- GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical compound OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 claims description 4
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Dermatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Birds (AREA)
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Gerontology & Geriatric Medicine (AREA)
- Cosmetics (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US54621404P | 2004-02-23 | 2004-02-23 | |
| US60/546,214 | 2004-02-23 | ||
| US56356604P | 2004-04-19 | 2004-04-19 | |
| US60/563,566 | 2004-04-19 | ||
| PCT/US2005/005726 WO2005081964A2 (en) | 2004-02-23 | 2005-02-23 | Topical delivery of a nitric oxide donor to improve body and skin appearance |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2556967A1 true CA2556967A1 (en) | 2005-09-09 |
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|---|---|---|---|
| CA002556967A Abandoned CA2556967A1 (en) | 2004-02-23 | 2005-02-23 | Topical delivery of a nitric oxide donor to improve body and skin appearance |
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|---|---|
| US (2) | US20080045909A1 (enExample) |
| EP (1) | EP1732577B1 (enExample) |
| JP (3) | JP5376761B2 (enExample) |
| AU (2) | AU2005216192B2 (enExample) |
| CA (1) | CA2556967A1 (enExample) |
| ES (1) | ES2421142T3 (enExample) |
| WO (1) | WO2005081964A2 (enExample) |
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| US7629384B2 (en) * | 1997-09-17 | 2009-12-08 | Strategic Science & Technologies, Llc | Topical delivery of L-arginine to cause beneficial effects |
| US7914814B2 (en) * | 1997-09-17 | 2011-03-29 | Strategic Science & Technologies, Llc | Topical delivery of arginine of cause beneficial effects |
| AU2005216192B2 (en) * | 2004-02-23 | 2010-11-04 | Strategic Science & Technologies, Llc | Topical delivery of a nitric oxide donor to improve body and skin appearance |
| US20110028548A1 (en) * | 2004-04-19 | 2011-02-03 | Strategic Science & Technologies, Llc | Beneficial effects of increasing local blood flow |
| US9226909B2 (en) | 2004-04-19 | 2016-01-05 | Strategic Science & Technologies, Llc | Beneficial effects of increasing local blood flow |
| AU2005235308B2 (en) * | 2004-04-19 | 2011-12-01 | Strategic Science & Technologies, Llc | Transdermal delivery of beneficial substances effected by a hostile biophysical environment |
| HUP0401422A2 (en) * | 2004-07-15 | 2006-04-28 | G Laszlo Meszaros | Use of l-arginine as vasoaktive ingredient absorbing through skin for external application |
| JP5274248B2 (ja) | 2005-05-27 | 2013-08-28 | ザ ユニバーシティ オブ ノース カロライナ アット チャペル ヒル | 酸化窒素治療及び医生物的応用のための酸化窒素放出粒子 |
| RU2009139781A (ru) * | 2007-03-27 | 2011-05-10 | Нолабс Аб (Se) | Устройство для доставки оксида азота для местного воздействия на кожу |
| ITBS20070177A1 (it) * | 2007-11-15 | 2009-05-16 | Paoli Ambrosi Gianfranco De | Composizione per uso topico per ottenere un rapido ed intenso effetto lifting |
| US20100098733A1 (en) * | 2008-10-16 | 2010-04-22 | Novan, Inc. | Nitric oxide releasing particles for oral care applications |
| WO2010151240A1 (en) | 2009-06-24 | 2010-12-29 | Strategic Science & Technologies, Llc | Topical composition containing ibuprofen |
| US12138268B2 (en) | 2009-06-24 | 2024-11-12 | Strategic Science & Technologies, Llc | Treatment of erectile dysfunction and other indications |
| US11684624B2 (en) | 2009-06-24 | 2023-06-27 | Strategic Science & Technologies, Llc | Treatment of erectile dysfunction and other indications |
| WO2010151241A1 (en) | 2009-06-24 | 2010-12-29 | Strategic Science & Technologies, Llc | Topical composition containing naproxen |
| ES2958410T3 (es) | 2009-08-21 | 2024-02-08 | Novan Inc | Geles tópicos |
| DK2467173T3 (da) | 2009-08-21 | 2019-07-29 | Novan Inc | Sårbandager, fremgangsmåder til anvendelse heraf og fremgangsmåder til dannelse deraf |
| BR112012008508A2 (pt) * | 2009-10-13 | 2017-06-13 | Novan Inc | revestimento de sol-gel, substrato, método para produzir um revestimento de sol-gel |
| EP4056193A1 (en) | 2010-06-17 | 2022-09-14 | New York University | Therapeutic and cosmetic uses and applications of calreticulin |
| WO2012027827A1 (en) * | 2010-08-30 | 2012-03-08 | Oral Delivery Technology Ltd. | Nitric oxide amino acid esters for skin rejuvenation |
| US8591876B2 (en) | 2010-12-15 | 2013-11-26 | Novan, Inc. | Methods of decreasing sebum production in the skin |
| DK2658551T3 (da) | 2010-12-29 | 2020-09-21 | Strategic Science & Tech Llc | Behandling af erektil dysfunktion og andre indikationer |
| CN105878172A (zh) | 2010-12-29 | 2016-08-24 | 战略科学与技术有限责任公司 | 治疗变态反应和其它适应症的系统和方法 |
| CN103370048B (zh) * | 2011-01-05 | 2016-06-01 | 花王株式会社 | 化妆品 |
| WO2012118819A2 (en) | 2011-02-28 | 2012-09-07 | Novan, Inc. | Nitric oxide-releasing s-nitrosothiol-modified silica particles and methods of making the same |
| WO2012177433A1 (en) | 2011-06-21 | 2012-12-27 | Evologie Llc | Topical compositions for the treatment of dermatological disorders |
| WO2013159140A1 (en) * | 2012-04-26 | 2013-10-31 | Edser Brenden | Eds005 skin cancer cream |
| WO2014152280A1 (en) | 2013-03-15 | 2014-09-25 | Strategic Science & Technologies, Llc | Transdermal formulations of fluticasone |
| EP2968130A1 (en) | 2013-03-15 | 2016-01-20 | Strategic Science & Technologies, LLC | Transdermal delivery of sildenafil and other phosphodiesterase type 5 inhibitors |
| US10517817B2 (en) * | 2013-05-09 | 2019-12-31 | Syk Technologies, Llc | Deep topical systemic nitric oxide therapy apparatus and method |
| WO2016112201A1 (en) | 2015-01-07 | 2016-07-14 | Strategic Science & Technologies, Llc | Techniques and systems for transdermal delivery involving treatment of psoriasis, skin cancer, and other indications |
| US10688069B2 (en) * | 2016-03-31 | 2020-06-23 | REV Pharmaceuticals LLC | Sports health performance composition |
| EP3395337B1 (en) * | 2017-04-28 | 2023-06-14 | Nitto Denko Corporation | Transdermal absorption preparation precursor |
| CA3083274A1 (en) * | 2017-11-27 | 2019-05-31 | Innovus Pharmaceuticals, Inc. | Systems and methods for topical creams for warming |
| CN111601617A (zh) | 2017-12-13 | 2020-08-28 | 上海岸阔医药科技有限公司 | 一种用于预防或治疗与egfr 被抑制相关疾病的方法 |
| WO2019169092A1 (en) | 2018-03-01 | 2019-09-06 | The Regents Of The University Of Michigan | Two-part nitric oxide generating topical compositions |
| JP7520366B2 (ja) | 2018-04-16 | 2024-07-23 | オンクオリティー ファーマシューティカルズ チャイナ リミテッド | 腫瘍療法の副作用の予防または治療方法 |
| CN108619061A (zh) * | 2018-07-11 | 2018-10-09 | 广东泓睿科技有限公司 | 一种丰胸乳液及其制备方法 |
| FR3083981B1 (fr) * | 2018-07-20 | 2021-01-15 | Semiocare Sas | Compositions a usage cosmetique et dermatologique |
| US20210000910A1 (en) | 2019-07-03 | 2021-01-07 | Jysk Skin Solutions Pte Ltd | Topical compositions |
| US12109195B2 (en) | 2020-06-30 | 2024-10-08 | Vireo Systems, Inc. | Compositions and methods for treatment of vaginal infections |
| DE212022000135U1 (de) * | 2021-01-15 | 2023-09-20 | Liliger Ltd | Topische Zusammensetzung |
| US12083204B2 (en) | 2022-06-02 | 2024-09-10 | L'oreal | Topical composition for homeostatic delivery of nitric oxide and uses thereof |
| CN116496436B (zh) * | 2023-04-28 | 2024-07-05 | 西安理工大学 | 多氢键网络基自修复高透明导电弹性体的制备方法及应用 |
| JP2025072314A (ja) * | 2023-10-24 | 2025-05-09 | アルバート アインシュタイン カレッジ オブ メディシン | 経皮送達製剤 |
Family Cites Families (127)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR1553063A (enExample) * | 1967-11-28 | 1969-01-10 | ||
| US3960782A (en) * | 1974-09-27 | 1976-06-01 | The Procter & Gamble Company | Shampoo compositions which impart high luster and manageability to hair |
| US4185100A (en) * | 1976-05-13 | 1980-01-22 | Johnson & Johnson | Topical anti-inflammatory drug therapy |
| FR2557452B1 (fr) * | 1983-12-28 | 1986-08-14 | Roussel Uclaf | Nouvelles compositions pour les soins de la peau renfermant de l'huile d'onagre et des traits tissulaires de rate |
| US4681897A (en) * | 1984-01-16 | 1987-07-21 | The Procter & Gamble Company | Pharmaceutical products providing enhanced analgesia |
| US4722837A (en) * | 1984-05-29 | 1988-02-02 | Derma-Cure, Inc. | Medicated shampoo composition |
| US4732892A (en) * | 1985-07-12 | 1988-03-22 | American Home Products Corporation | L-α-amino acids as transdermal penetration enhancers |
| EP0226332B1 (en) * | 1985-11-18 | 1992-03-25 | Beecham Group Plc | Veterinary compositions |
| GB8606368D0 (en) * | 1986-03-14 | 1986-04-23 | Unilever Plc | Skin treatment composition |
| US4885157A (en) * | 1987-02-13 | 1989-12-05 | Fiaschetti Mary G | Dermal cosmetic composition and applications therefor |
| US5925372A (en) * | 1987-12-16 | 1999-07-20 | Novartis Corporation | Mixed solvent mutually enhanced transdermal therapeutic system |
| US4871718A (en) * | 1987-12-29 | 1989-10-03 | Raymond A. Roncari | Composition of matter for increasing intracellular ATP levels and physical performance levels and for increasing the rate of wound repair |
| DE3827362A1 (de) * | 1988-08-12 | 1990-02-15 | Basf Ag | Pulvrige, hydrophile theophyllinformulierung und verfahren zur ihrer herstellung |
| EP0406347A4 (en) * | 1988-09-30 | 1991-04-03 | Kazuo Watanabe | Anti-inflammatory and analgesic compounds, related compositions and methods for preparation and use thereof |
| US4945901A (en) * | 1989-03-22 | 1990-08-07 | Burcke Jr Harry J | Hand therapy apparatus and method therefor |
| US5158761A (en) * | 1989-04-05 | 1992-10-27 | Toko Yakuhin Kogyo Kabushiki Kaisha | Spray gel base and spray gel preparation using thereof |
| US5476852A (en) * | 1989-05-03 | 1995-12-19 | Janssen Pharmaceutica N.V. | Method of topically treating acne vulgaris, hyperkeratotic dermatoses, and photo-aging of the skin |
| US5028435A (en) * | 1989-05-22 | 1991-07-02 | Advanced Polymer Systems, Inc. | System and method for transdermal drug delivery |
| JP2761939B2 (ja) * | 1989-09-04 | 1998-06-04 | 株式会社コーセー | 水中油型乳化化粧料 |
| US5576351A (en) * | 1989-12-29 | 1996-11-19 | Mcgaw, Inc. | Use of arginine as an immunostimulator |
| EP0441119A3 (en) * | 1990-01-09 | 1992-10-14 | Richard D. Levere | The use of l-arginine in the treatment of hypertension and other vascular disorders |
| US5332758A (en) * | 1990-07-13 | 1994-07-26 | Kanebo, Ltd. | Collagen metabolism ameliorant and its use |
| US5824658A (en) * | 1990-09-18 | 1998-10-20 | Hyal Pharmaceutical Corporation | Topical composition containing hyaluronic acid and NSAIDS |
| DE4100975A1 (de) * | 1991-01-15 | 1992-07-16 | Weuffen Wolfgang | Kosmetische oder pharmazeutische zubereitungen zur verbesserung der haarqualitaet und foerderung des haarwachstums |
| US5210099A (en) * | 1991-02-11 | 1993-05-11 | American Home Products Corporation | Analgesic compositions |
| RU93053628A (ru) * | 1991-03-01 | 1996-11-10 | Атертон Инвестментс | Активный ингредиент, способ его получения, композиция на его основе, способ ее приготовления |
| ES2108110T3 (es) * | 1991-03-01 | 1997-12-16 | Atherton Investments Ltd | Composiciones terapeuticas y cosmeticas para el tratamiento de la piel. |
| US5498420A (en) * | 1991-04-12 | 1996-03-12 | Merz & Co. Gmbh & Co. | Stable small particle liposome preparations, their production and use in topical cosmetic, and pharmaceutical compositions |
| JP2636118B2 (ja) * | 1991-09-10 | 1997-07-30 | 三省製薬株式会社 | 育毛剤 |
| US5254331A (en) * | 1991-09-12 | 1993-10-19 | Chanel, Inc. | Skin cream composition |
| US5215759A (en) * | 1991-10-01 | 1993-06-01 | Chanel, Inc. | Cosmetic composition |
| US5217652A (en) * | 1991-10-04 | 1993-06-08 | The Gillette Company | Conditioning shampoo |
| ES2120477T3 (es) * | 1992-01-21 | 1998-11-01 | Macrochem Corp | Administracion iontoforetica de medicamentos perfeccionada. |
| US5691423A (en) * | 1992-08-24 | 1997-11-25 | The United States Of America As Represented By The Department Of Health And Human Services | Polysaccharide-bound nitric oxide-nucleophile adducts |
| US5632981A (en) * | 1992-08-24 | 1997-05-27 | The United States Of America As Represented By The Department Of Health And Human Services | Biopolymer-bound nitric oxide-releasing compositions, pharmaceutical compositions incorporating same and methods of treating biological disorders using same |
| US5405919A (en) * | 1992-08-24 | 1995-04-11 | The United States Of America As Represented By The Secretary Of Health And Human Services | Polymer-bound nitric oxide/nucleophile adduct compositions, pharmaceutical compositions and methods of treating biological disorders |
| KR100271225B1 (ko) * | 1992-08-31 | 2000-11-01 | 후나키 토시유키 | 안전스위치장치 |
| US5439938A (en) * | 1993-04-07 | 1995-08-08 | The Johns Hopkins University | Treatments for male sexual dysfunction |
| US5891459A (en) * | 1993-06-11 | 1999-04-06 | The Board Of Trustees Of The Leland Stanford Junior University | Enhancement of vascular function by modulation of endogenous nitric oxide production or activity |
| US5428070A (en) * | 1993-06-11 | 1995-06-27 | The Board Of Trustees Of The Leland Stanford Junior University | Treatment of vascular degenerative diseases by modulation of endogenous nitric oxide production of activity |
| US5714472A (en) * | 1993-12-23 | 1998-02-03 | Nestec Ltd. | Enternal formulation designed for optimized nutrient absorption and wound healing |
| GB9409281D0 (en) * | 1994-05-10 | 1994-06-29 | Svedman Paul | Transdermal device |
| US5543430A (en) * | 1994-10-05 | 1996-08-06 | Kaesemeyer; W. H. | Method and formulation of stimulating nitric oxide synthesis |
| US5505958A (en) * | 1994-10-31 | 1996-04-09 | Algos Pharmaceutical Corporation | Transdermal drug delivery device and method for its manufacture |
| EP0789584B1 (de) * | 1994-11-04 | 2001-09-19 | Polymun Scientific Immunbiologische Forschung GmbH | Applikation von sod in liposomen |
| US5648101A (en) * | 1994-11-14 | 1997-07-15 | Tawashi; Rashad | Drug delivery of nitric oxide |
| US5562917A (en) * | 1994-12-23 | 1996-10-08 | Pentech Pharmaceuticals, Inc. | Transdermal administration of apomorphine |
| US5595753A (en) * | 1995-04-14 | 1997-01-21 | President And Fellows Of Harvard College | Topical formulations and methods for treating hemorrhoidal pain and sphincter and smooth muscle spasm in the gastrointestinal tract |
| US5643586A (en) * | 1995-04-27 | 1997-07-01 | Perricone; Nicholas V. | Topical compositions and methods for treatment of skin damage and aging using catecholamines and related compounds |
| US5762963A (en) * | 1995-06-07 | 1998-06-09 | Emory University | Method and compositions for controlling oral and pharyngeal pain using capsaicinoids |
| US5645859A (en) * | 1995-10-02 | 1997-07-08 | Isp Investments Inc. | Process for producing an alpha or beta-hydroxy acid-vinylpyrrolidone polymer, copolymer or graft polymer complex in the form of free-flowing powders having a high acid loading |
| US5605685A (en) * | 1995-09-13 | 1997-02-25 | Isp Investments Inc. | Non-irritating skin and hair rejuvenating compostion having a pH between 1 and 6.5 |
| US6036977A (en) * | 1995-09-29 | 2000-03-14 | L.A.M. Pharmaceutical Corp. | Drug preparations for treating sexual dysfunction |
| FR2740339B1 (fr) * | 1995-10-26 | 1997-12-05 | Oreal | Utilisation d'au moins un inhibiteur de no-synthase dans le traitement des peaux sensibles |
| US5716436B1 (en) * | 1995-11-30 | 1999-08-24 | Eastman Kodak Co | Ink jet containing polyester ionomers |
| US5789442A (en) * | 1996-01-18 | 1998-08-04 | Schering Aktiengesellschaft | Treatment of urinary incontinence with nitric oxide synthase substrates and/or nitric oxide donors alone or in combination with estrogen or progesterone and/or other agents |
| GB9608408D0 (en) * | 1996-04-23 | 1996-06-26 | Adams Michael A | Treatment of erectile dysfunction |
| US5911980A (en) * | 1996-06-27 | 1999-06-15 | Macrochem Corporation | Lipophilic and amphiphilic or hydrophilic film-forming polymer compositions, and use thereof in topical agent delivery system and method of delivering agents to the skin |
| US20020015713A1 (en) * | 1996-10-24 | 2002-02-07 | Murdock Robert W. | Methods and transdermal compositions for pain relief |
| US5891472A (en) * | 1996-11-19 | 1999-04-06 | Meri Charmyne Russell | Treatment of equine laminitis |
| JPH10167953A (ja) * | 1996-12-06 | 1998-06-23 | Daicel Chem Ind Ltd | 化粧品組成物 |
| US5807957A (en) * | 1996-12-23 | 1998-09-15 | Macrochem Corporation | Cationic film-forming polymer compositions, and use thereof in topical agents delivery system and method of delivering agents to the skin |
| IL120531A (en) * | 1997-03-26 | 2006-12-31 | Yissum Res Dev Co | Nitric oxide donors and pharmaceutical compositions containing them |
| FR2762782B1 (fr) * | 1997-05-05 | 1999-06-11 | Oreal | Composition comprenant un milieu de culture de micro-organisme et utilisation |
| DE69842142D1 (de) * | 1997-07-03 | 2011-04-07 | Us Gov Health & Human Serv | Stickoxid freistetzende amidin- und enaminverwandte diazeniumdiolate, zubereitungen und verwendungen davon und verfahren zu ihrer herstellung |
| US5976566A (en) * | 1997-08-29 | 1999-11-02 | Macrochem Corporation | Non-steroidal antiinflammtory drug formulations for topical application to the skin |
| US7629384B2 (en) * | 1997-09-17 | 2009-12-08 | Strategic Science & Technologies, Llc | Topical delivery of L-arginine to cause beneficial effects |
| ES2340450T3 (es) * | 1997-09-17 | 2010-06-02 | STRATEGIC SCIENCE & TECHNOLOGIES, LLC | Un suministro de arginina para el calentamiento de tejidos frios/enfriados. |
| US5895658A (en) * | 1997-09-17 | 1999-04-20 | Fossel; Eric T. | Topical delivery of L-arginine to cause tissue warming |
| US6207713B1 (en) * | 1997-09-17 | 2001-03-27 | Eric T. Fossel | Topical and oral delivery of arginine to cause beneficial effects |
| US5922332A (en) * | 1997-09-17 | 1999-07-13 | Fossel; Eric T. | Topical delivery of arginine to overcome pain |
| US7914814B2 (en) * | 1997-09-17 | 2011-03-29 | Strategic Science & Technologies, Llc | Topical delivery of arginine of cause beneficial effects |
| US6096759A (en) * | 1997-09-19 | 2000-08-01 | Georgetown University | Method for treating essential hypertension |
| US5906822A (en) * | 1997-09-25 | 1999-05-25 | Macrochem Corporation | Cationic film-forming polymer compositions, and use thereof in topical agents delivery system and method of delivering agents to the skin |
| WO1999017712A2 (de) * | 1997-10-08 | 1999-04-15 | Genesiscosmetics Rights & Licenses Company Limited | Straffung und/oder verkleinerung von fettzellen-haltigen körperpartien |
| US6031888A (en) * | 1997-11-26 | 2000-02-29 | Picker International, Inc. | Fluoro-assist feature for a diagnostic imaging device |
| GB9801398D0 (en) * | 1998-01-22 | 1998-03-18 | Anggard Erik E | Chemical compounds |
| CN1303279A (zh) * | 1998-06-01 | 2001-07-11 | A·J·沃比斯卡 | 局部透皮疗法 |
| US6103275A (en) * | 1998-06-10 | 2000-08-15 | Nitric Oxide Solutions | Systems and methods for topical treatment with nitric oxide |
| US6117872A (en) * | 1998-06-23 | 2000-09-12 | The Board Of Trustees Of The Leland Stanford Junior University | Enhancement of exercise performance by augmenting endogenous nitric oxide production or activity |
| EP1094781B1 (en) * | 1998-07-07 | 2008-07-02 | Transdermal Technologies Inc. | Compositions for rapid and non-irritating transdermal delivery of pharmaceutically active agents and methods for formulating such compositions and delivery thereof |
| DE19830649C2 (de) * | 1998-07-09 | 2003-04-10 | Lohmann Therapie Syst Lts | Topisches Pflaster mit nichtsteroidalen Antirheumatika mit Säuregruppe |
| DE19831798A1 (de) * | 1998-07-15 | 2000-01-27 | Mandorlo Investment Gmbh Luxem | Mittel zur Pflege und/oder Behandlung von Haut und Gewebe |
| KR20010080324A (ko) * | 1998-10-26 | 2001-08-22 | 조셉 에프. 엑스. 맥과이얼 | 아데노신 또는 아데노신 유사체를 사용한 피부 치료방법 |
| US6261594B1 (en) * | 1998-11-25 | 2001-07-17 | The University Of Akron | Chitosan-based nitric oxide donor compositions |
| JP2000186028A (ja) * | 1998-12-21 | 2000-07-04 | Nobuko Koga | 化粧品 |
| FR2787996B1 (fr) * | 1998-12-30 | 2002-05-10 | Dior Christian Parfums | Composition cosmetique ou dermatologique contenant un actif stimulant la synthese de la proteine hsp 32 dans la peau et methode de traitement cosmetique |
| MXPA01009140A (es) * | 1999-03-12 | 2003-07-14 | Howard Cooper Troy | Aparato formador de vapor para la aplicacion de materiales de recubrimiento a la superficie de la piel. |
| US6375672B1 (en) * | 1999-03-22 | 2002-04-23 | Board Of Trustees Of Michigan State University | Method for controlling the chemical and heat induced responses of collagenous materials |
| FR2794974B1 (fr) * | 1999-06-16 | 2001-08-17 | Exsymol Sa | Composition cosmetique pour l'amincissement a base de l-arginine, d'un analogue de l-arginine ou d'un de leurs derives, applicable par voie topique |
| KR100876753B1 (ko) * | 1999-09-07 | 2009-01-07 | 가부시끼가이샤 소껭 | 피부 건전화제 |
| US6565879B1 (en) * | 1999-12-16 | 2003-05-20 | Dermatrends, Inc. | Topical and transdermal administration of peptidyl drugs with hydroxide-releasing agents as skin permeation enhancers |
| US6586000B2 (en) * | 1999-12-16 | 2003-07-01 | Dermatrends, Inc. | Hydroxide-releasing agents as skin permeation enhancers |
| US6562370B2 (en) * | 1999-12-16 | 2003-05-13 | Dermatrends, Inc. | Transdermal administration of steroid drugs using hydroxide-releasing agents as permeation enhancers |
| US6582724B2 (en) * | 1999-12-16 | 2003-06-24 | Dermatrends, Inc. | Dual enhancer composition for topical and transdermal drug delivery |
| US6558695B2 (en) * | 1999-12-16 | 2003-05-06 | Dermatrends, Inc. | Topical and transdermal administration of peptidyl drugs using hydroxide releasing agents as permeation enhancers |
| US6602912B2 (en) * | 2000-06-30 | 2003-08-05 | Dermatrends, Inc. | Transdermal administration of phenylpropanolamine |
| US6719997B2 (en) * | 2000-06-30 | 2004-04-13 | Dermatrends, Inc. | Transdermal administration of pharmacologically active amines using hydroxide-releasing agents as permeation enhancers |
| FR2802414B1 (fr) * | 1999-12-20 | 2003-06-27 | G Pharm Lab | Composition, notamment cosmetique ou dermatologique, contenant des oligosaccharides, son procede de preparation et un procede de traitement cosmetique |
| JP2001288068A (ja) * | 2000-04-06 | 2001-10-16 | Nof Corp | 皮膚化粧料 |
| FR2810540B1 (fr) * | 2000-06-21 | 2004-04-30 | C3D | Nouvelles preparations cosmetiques ou hygieniques sous forme de dispersion |
| JP2002003373A (ja) * | 2000-06-27 | 2002-01-09 | Shiseido Co Ltd | 皮膚外用剤 |
| US6538033B2 (en) * | 2000-08-29 | 2003-03-25 | Huntington Medical Research Institutes | Nitric oxide donor compounds |
| US20020168325A1 (en) * | 2001-01-25 | 2002-11-14 | Ethan Lerner | NOS inhibitors for treatment of wrinkles |
| WO2002087700A1 (en) * | 2001-04-26 | 2002-11-07 | The Procter & Gamble Company | Method, kit and device for the treatment of cosmetic skin conditions |
| DE10128910A1 (de) * | 2001-06-15 | 2002-12-19 | Beiersdorf Ag | Verwendung von Wirkstoffkombinationen aus Arginin und Ascorbinsäure zur Hautstraffung |
| US20030157185A1 (en) * | 2002-02-08 | 2003-08-21 | Lou Paradise | Topical treatment of neuropathy |
| JP4229842B2 (ja) * | 2002-02-22 | 2009-02-25 | ルバンス セラピュティックス インク． | Ｌ−アルギニンオリゴマーを含む化粧品処方 |
| JP2003286129A (ja) * | 2002-03-27 | 2003-10-07 | Hakugen:Kk | 痩身シート材 |
| US20020168424A1 (en) * | 2002-07-31 | 2002-11-14 | Dr. Mohsen Shahinpoor | Nitric oxide (NO) donor+cGMP-PDE5 inhibitor as a topical drug for glaucoma |
| US7241456B2 (en) * | 2002-10-25 | 2007-07-10 | Australian Importers Ltd. | Formulations for topical delivery of bioactive substances and methods for their use |
| AU2003903037A0 (en) * | 2003-06-17 | 2003-07-03 | Institute Of Nutraceutical Research | Connective tissue derived polypeptides |
| WO2004112723A2 (en) * | 2003-06-20 | 2004-12-29 | Ronald Aung-Din | Tropical therapy for the treatment of migraines, muscle sprains, muscle spasm, spasticity and related conditions |
| US20050069590A1 (en) * | 2003-09-30 | 2005-03-31 | Buehler Gail K. | Stable suspensions for medicinal dosages |
| JP2005200370A (ja) * | 2004-01-16 | 2005-07-28 | Nikko Chemical Co Ltd | 一酸化窒素産生促進剤およびその利用 |
| AU2005216192B2 (en) * | 2004-02-23 | 2010-11-04 | Strategic Science & Technologies, Llc | Topical delivery of a nitric oxide donor to improve body and skin appearance |
| US20090105336A1 (en) * | 2004-04-19 | 2009-04-23 | Strategic Science & Technologies, Llc | Beneficial Effects of Increasing Local Blood Flow |
| AU2005235308B2 (en) * | 2004-04-19 | 2011-12-01 | Strategic Science & Technologies, Llc | Transdermal delivery of beneficial substances effected by a hostile biophysical environment |
| US20110028548A1 (en) * | 2004-04-19 | 2011-02-03 | Strategic Science & Technologies, Llc | Beneficial effects of increasing local blood flow |
| US20070087977A1 (en) * | 2004-11-16 | 2007-04-19 | Wendye Robbins | Methods and compositions for treating pain |
| US7442690B2 (en) * | 2005-03-14 | 2008-10-28 | P & L Enterprise Llc | Topical treatment for psoriasis |
| EP1770086A1 (de) * | 2005-09-29 | 2007-04-04 | Boehringer Ingelheim Pharma GmbH & Co. KG | Ausgewählte CGRP-Antagonisten, Verfahren zu deren Herstellung sowie deren Verwendung als Arzneimittel |
| CA2823407C (en) * | 2007-03-22 | 2016-10-18 | Berg Pharma Llc | Topical formulations having enhanced bioavailability |
| US8686040B2 (en) * | 2008-03-31 | 2014-04-01 | Rdd Pharma Ltd. | Method for treating anal pruritis and other perianal disorders |
| US8969081B2 (en) * | 2008-12-10 | 2015-03-03 | The Trustees Of Columbia University In The City Of New York | Caudal motor neuron derived from embryonic stem cells under conditions essentially free of any retinoid |
| WO2010151240A1 (en) * | 2009-06-24 | 2010-12-29 | Strategic Science & Technologies, Llc | Topical composition containing ibuprofen |
| WO2010151241A1 (en) * | 2009-06-24 | 2010-12-29 | Strategic Science & Technologies, Llc | Topical composition containing naproxen |
-
2005
- 2005-02-23 AU AU2005216192A patent/AU2005216192B2/en not_active Ceased
- 2005-02-23 JP JP2006554318A patent/JP5376761B2/ja not_active Expired - Fee Related
- 2005-02-23 US US10/590,300 patent/US20080045909A1/en not_active Abandoned
- 2005-02-23 CA CA002556967A patent/CA2556967A1/en not_active Abandoned
- 2005-02-23 WO PCT/US2005/005726 patent/WO2005081964A2/en not_active Ceased
- 2005-02-23 ES ES05723558T patent/ES2421142T3/es not_active Expired - Lifetime
- 2005-02-23 EP EP05723558.2A patent/EP1732577B1/en not_active Expired - Lifetime
-
2010
- 2010-04-15 US US12/761,034 patent/US20100196517A1/en not_active Abandoned
-
2011
- 2011-01-19 AU AU2011200202A patent/AU2011200202B2/en not_active Ceased
- 2011-03-15 JP JP2011057285A patent/JP2011116787A/ja active Pending
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2012
- 2012-03-09 JP JP2012053145A patent/JP2012107071A/ja not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| AU2011200202A1 (en) | 2011-02-10 |
| JP2011116787A (ja) | 2011-06-16 |
| AU2011200202B2 (en) | 2013-03-21 |
| US20100196517A1 (en) | 2010-08-05 |
| EP1732577A4 (en) | 2009-03-18 |
| US20080045909A1 (en) | 2008-02-21 |
| EP1732577B1 (en) | 2013-04-10 |
| JP2012107071A (ja) | 2012-06-07 |
| ES2421142T3 (es) | 2013-08-29 |
| JP2007523195A (ja) | 2007-08-16 |
| EP1732577A2 (en) | 2006-12-20 |
| AU2005216192A1 (en) | 2005-09-09 |
| JP5376761B2 (ja) | 2013-12-25 |
| WO2005081964A3 (en) | 2005-12-08 |
| AU2005216192B2 (en) | 2010-11-04 |
| WO2005081964A2 (en) | 2005-09-09 |
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