JP2011102304A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2011102304A5 JP2011102304A5 JP2010286329A JP2010286329A JP2011102304A5 JP 2011102304 A5 JP2011102304 A5 JP 2011102304A5 JP 2010286329 A JP2010286329 A JP 2010286329A JP 2010286329 A JP2010286329 A JP 2010286329A JP 2011102304 A5 JP2011102304 A5 JP 2011102304A5
- Authority
- JP
- Japan
- Prior art keywords
- unit dosage
- compound
- pathogenic cell
- host animal
- compound according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 0 CC[C@](CC1[C@](C)C1Cc(cc([C@](CC1)(C2N1CC=C[C@@]2(CC)[C@@]([C@@]1(*)O)O)C1(C)N1C)c1c1)c1OC)(CN(*)CCc1c(CC(OC)=O)[n]c2ccccc12)O Chemical compound CC[C@](CC1[C@](C)C1Cc(cc([C@](CC1)(C2N1CC=C[C@@]2(CC)[C@@]([C@@]1(*)O)O)C1(C)N1C)c1c1)c1OC)(CN(*)CCc1c(CC(OC)=O)[n]c2ccccc12)O 0.000 description 1
- CAAKXFHZUSSLMC-PTVYPEDCSA-N NCCCC(C(N[C@@H](CC(O)=O)C(N[C@@H](CC(O)=O)C(NC(CSSCCO)C(O)=O)=O)=O)=O)NC(C(CC(O)=O)NC(CC[C@@H](C(O)=O)NC(c(cc1)ccc1NCc(cn1)nc2c1N=C(N)NC2=O)=O)=O)=O Chemical compound NCCCC(C(N[C@@H](CC(O)=O)C(N[C@@H](CC(O)=O)C(NC(CSSCCO)C(O)=O)=O)=O)=O)NC(C(CC(O)=O)NC(CC[C@@H](C(O)=O)NC(c(cc1)ccc1NCc(cn1)nc2c1N=C(N)NC2=O)=O)=O)=O CAAKXFHZUSSLMC-PTVYPEDCSA-N 0.000 description 1
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US44284503P | 2003-01-27 | 2003-01-27 | |
| US60/442,845 | 2003-01-27 | ||
| US49211903P | 2003-08-01 | 2003-08-01 | |
| US60/492,119 | 2003-08-01 | ||
| US51618803P | 2003-10-31 | 2003-10-31 | |
| US60/516,188 | 2003-10-31 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2005518938A Division JP5576007B2 (ja) | 2003-01-27 | 2004-01-27 | ビタミン受容体結合性薬剤送達結合体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011102304A JP2011102304A (ja) | 2011-05-26 |
| JP2011102304A5 true JP2011102304A5 (show.php) | 2011-09-15 |
| JP4815009B2 JP4815009B2 (ja) | 2011-11-16 |
Family
ID=32854293
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2005518938A Expired - Fee Related JP5576007B2 (ja) | 2003-01-27 | 2004-01-27 | ビタミン受容体結合性薬剤送達結合体 |
| JP2010286329A Expired - Fee Related JP4815009B2 (ja) | 2003-01-27 | 2010-12-22 | ビタミン受容体結合性薬剤送達結合体 |
| JP2011165553A Expired - Fee Related JP5721580B2 (ja) | 2003-01-27 | 2011-07-28 | ビタミン受容体結合性薬剤送達結合体 |
| JP2014246193A Withdrawn JP2015078215A (ja) | 2003-01-27 | 2014-12-04 | ビタミン受容体結合性薬剤送達結合体 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2005518938A Expired - Fee Related JP5576007B2 (ja) | 2003-01-27 | 2004-01-27 | ビタミン受容体結合性薬剤送達結合体 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011165553A Expired - Fee Related JP5721580B2 (ja) | 2003-01-27 | 2011-07-28 | ビタミン受容体結合性薬剤送達結合体 |
| JP2014246193A Withdrawn JP2015078215A (ja) | 2003-01-27 | 2014-12-04 | ビタミン受容体結合性薬剤送達結合体 |
Country Status (14)
| Country | Link |
|---|---|
| US (6) | US7601332B2 (show.php) |
| EP (4) | EP1592457B1 (show.php) |
| JP (4) | JP5576007B2 (show.php) |
| AR (1) | AR042942A1 (show.php) |
| AU (1) | AU2004210136C1 (show.php) |
| CA (1) | CA2512867C (show.php) |
| CY (1) | CY1113258T1 (show.php) |
| DK (1) | DK1592457T3 (show.php) |
| ES (1) | ES2395082T3 (show.php) |
| IL (2) | IL169469A (show.php) |
| NZ (1) | NZ541846A (show.php) |
| PT (1) | PT1592457E (show.php) |
| TW (3) | TWI405573B (show.php) |
| WO (1) | WO2004069159A2 (show.php) |
Families Citing this family (112)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EA005823B1 (ru) | 2000-03-31 | 2005-06-30 | Пердью Рисерч Фаундейшн | Способ лечения с использованием конъюгатов лиганд-иммуноген |
| EP1389209B1 (en) * | 2001-04-24 | 2009-04-08 | Purdue Research Foundation | Folate mimetics and folate-receptor binding conjugates thereof |
| CN1635910A (zh) | 2001-05-02 | 2005-07-06 | 普渡研究基金会 | 巨噬细胞介导的疾病的治疗和诊断 |
| EP1434603B1 (en) * | 2001-09-28 | 2009-12-16 | Purdue Research Foundation | Method of treatment using ligand-immunogen conjugates |
| US8043603B2 (en) * | 2002-02-07 | 2011-10-25 | Endocyte, Inc. | Folate targeted enhanced tumor and folate receptor positive tissue optical imaging technology |
| US8043602B2 (en) | 2002-02-07 | 2011-10-25 | Endocyte, Inc. | Folate targeted enhanced tumor and folate receptor positive tissue optical imaging technology |
| ES2500922T3 (es) | 2002-05-06 | 2014-10-01 | Endocyte, Inc. | Agentes de formación de imágenes dirigidos al receptor de folato |
| ES2324708T3 (es) * | 2002-05-15 | 2009-08-13 | Endocyte, Inc. | Conjugados de vitamina-mitomicina. |
| BR122012021252B8 (pt) | 2002-09-06 | 2021-05-25 | Cerulean Pharma Inc | polímeros à base de ciclodextrina para o fornecimento de agentes terapêuticos ligados a eles por covalência |
| EP1592457B1 (en) * | 2003-01-27 | 2012-07-25 | Endocyte, Inc. | Folate-vinblastine conjugate as medicament |
| ATE412897T1 (de) | 2003-05-30 | 2008-11-15 | Purdue Research Foundation | Diagnoseverfahren für atherosklerose |
| FR2865736B1 (fr) * | 2004-02-02 | 2006-07-14 | Synt Em | Inhibiteurs de l'angiogenese, compositions les contenant et leur utilisation pour le traitement des maladies liees a une deregulation de l'angiogenese |
| US8288557B2 (en) | 2004-07-23 | 2012-10-16 | Endocyte, Inc. | Bivalent linkers and conjugates thereof |
| EP2266622A3 (en) | 2004-08-26 | 2012-06-20 | Piramal Life Sciences Limited | Prodrugs containing novel bio-cleavable linkers |
| TW200616604A (en) | 2004-08-26 | 2006-06-01 | Nicholas Piramal India Ltd | Nitric oxide releasing prodrugs containing bio-cleavable linker |
| JP2009221164A (ja) | 2008-03-17 | 2009-10-01 | Nitto Denko Corp | 肺線維症処置剤 |
| SI2730277T1 (sl) | 2004-12-22 | 2020-07-31 | Nitto Denko Corporation | Nosilec zdravila in komplet za nosilec zdravila za zaviranje fibroze |
| CN101128152A (zh) * | 2004-12-23 | 2008-02-20 | 普渡研究基金会 | 发射正电子段层成像方法 |
| CN101175757B (zh) * | 2005-03-16 | 2012-11-14 | 恩多塞特公司 | 蝶酸及其缀合物的合成和纯化 |
| AU2006230219A1 (en) * | 2005-03-30 | 2006-10-05 | Endocyte, Inc. | Method for cancer prognosis using cellular folate vitamin receptor quantification |
| WO2007006041A2 (en) * | 2005-07-05 | 2007-01-11 | Purdue Research Foundation | Imaging and therapeutic method using monocytes |
| EP1948240A2 (en) * | 2005-08-19 | 2008-07-30 | Endocyte, Inc. | Ligand conjugates of vinca alkaloids, analogs and derivatives |
| CN103893779A (zh) * | 2005-08-19 | 2014-07-02 | 恩多塞特公司 | 多药物配体缀合物 |
| EP1940473A2 (en) | 2005-09-23 | 2008-07-09 | Purdue Research Foundation | Multiphoton in vivo flow cytometry method and device |
| US9572886B2 (en) | 2005-12-22 | 2017-02-21 | Nitto Denko Corporation | Agent for treating myelofibrosis |
| JP5346589B2 (ja) * | 2006-02-02 | 2013-11-20 | シンタルガ・ビーブイ | 水溶性cc−1065類似体及びその接合体 |
| WO2007092299A2 (en) * | 2006-02-03 | 2007-08-16 | Purdue Research Foundation | Targeted conjugates and radiation |
| CA2643826A1 (en) * | 2006-02-27 | 2008-06-12 | Paul A. Wender | Compositions and methods for transport of molecules with enhanced release properties across biological barriers |
| WO2007139815A2 (en) * | 2006-05-23 | 2007-12-06 | Purdue Research Foundation | Imaging and therapeutic method using progenitor cells |
| PE20080102A1 (es) * | 2006-05-25 | 2008-02-11 | Bristol Myers Squibb Co | Conjugados de analogos de aziridinil-epotilona y composiciones farmaceuticas que comprenden los mismos |
| AR061181A1 (es) * | 2006-05-25 | 2008-08-13 | Bristol Myers Squibb Co | Compuestos de aziridinil-epotilona |
| CA2668197A1 (en) | 2006-11-03 | 2008-05-15 | Philip S. Low | Ex vivo flow cytometry method and device |
| TWI412367B (zh) * | 2006-12-28 | 2013-10-21 | Medarex Llc | 化學鏈接劑與可裂解基質以及其之綴合物 |
| US20080176958A1 (en) | 2007-01-24 | 2008-07-24 | Insert Therapeutics, Inc. | Cyclodextrin-based polymers for therapeutics delivery |
| JP5869205B2 (ja) | 2007-02-07 | 2016-02-24 | パーデュー・リサーチ・ファウンデーションPurdue Research Foundation | ポジトロン放射断層画像法 |
| US20100104626A1 (en) * | 2007-02-16 | 2010-04-29 | Endocyte, Inc. | Methods and compositions for treating and diagnosing kidney disease |
| CN101616911A (zh) | 2007-02-21 | 2009-12-30 | 梅达莱克斯公司 | 具有单个氨基酸的化学连接物及其偶联物 |
| CN101678124A (zh) * | 2007-03-14 | 2010-03-24 | 恩多塞特公司 | 结合配体连接的微管溶素递药缀合物 |
| JP5693950B2 (ja) | 2007-04-11 | 2015-04-01 | メルク エ カンパニー | 18f標識葉酸 |
| US8961926B2 (en) | 2007-05-25 | 2015-02-24 | Purdue Research Foundation | Method of imaging localized infections |
| EP2152717A1 (en) | 2007-05-25 | 2010-02-17 | Bristol-Myers Squibb Company | Processes for making epothilone compounds and analogs |
| US9877965B2 (en) | 2007-06-25 | 2018-01-30 | Endocyte, Inc. | Vitamin receptor drug delivery conjugates for treating inflammation |
| CN104383553A (zh) | 2007-06-25 | 2015-03-04 | 恩多塞特公司 | 含有亲水性间隔区接头的共轭物 |
| US9901567B2 (en) | 2007-08-01 | 2018-02-27 | Syntarga B.V. | Substituted CC-1065 analogs and their conjugates |
| NZ583931A (en) | 2007-08-17 | 2012-06-29 | Purdue Research Foundation | Psma binding ligand-linker conjugates and methods for using |
| AU2008316835B2 (en) | 2007-10-25 | 2015-07-16 | Endocyte, Inc. | Tubulysins and processes for preparing |
| US20110105417A1 (en) * | 2008-06-26 | 2011-05-05 | The Curators Of The University Of Missouri | Drug Conjugates |
| CA2737496A1 (en) | 2008-09-17 | 2010-03-25 | Endocyte, Inc. | Folate receptor binding conjugates of antifolates |
| HUE035798T2 (en) | 2008-11-03 | 2018-05-28 | Syntarga Bv | CC-1065 analogues and conjugates |
| AU2010278734A1 (en) * | 2009-07-31 | 2012-02-23 | Endocyte, Inc. | Folate-targeted diagnostics and treatment |
| KR20120061053A (ko) | 2009-08-27 | 2012-06-12 | 시냅틱 리서치, 엘엘씨 | 유도 만능 줄기(iPS) 세포 또는 조직 특이적 세포를 생성하기 위한 신규한 단백질 전달 시스템 |
| JP5780961B2 (ja) * | 2009-09-07 | 2015-09-16 | ニプロパッチ株式会社 | 経皮吸収型製剤 |
| WO2011069116A1 (en) * | 2009-12-04 | 2011-06-09 | Endocyte, Inc. | Binding ligand linked drug delivery conjugates of tubulysins |
| US9951324B2 (en) | 2010-02-25 | 2018-04-24 | Purdue Research Foundation | PSMA binding ligand-linker conjugates and methods for using |
| WO2011130716A2 (en) | 2010-04-16 | 2011-10-20 | Access Pharmaceuticals, Inc. | A nanostructures containing vitamin b12 for facilitated delivery of drugs across biological barriers |
| HUE030846T2 (en) | 2010-04-21 | 2017-06-28 | Syntarga Bv | Conjugates of cc-1065 analogs and bifunctional linkers |
| JP5950428B2 (ja) | 2010-08-05 | 2016-07-13 | 日東電工株式会社 | 線維化組織から正常組織を再生するための組成物 |
| SG187728A1 (en) | 2010-08-06 | 2013-03-28 | Endocyte Inc | Processes for preparing tubulysins |
| SG190244A1 (en) * | 2010-11-12 | 2013-06-28 | Endocyte Inc | Methods of treating cancer |
| US20140243282A1 (en) * | 2010-12-31 | 2014-08-28 | Satish Reddy Kallam | Methods and compositions for designing novel conjugate therapeutics |
| CN103501821A (zh) | 2011-03-08 | 2014-01-08 | 艾克塞斯制药公司 | 用于递送活性剂穿过生物膜的靶向纳米载体系统 |
| SG194458A1 (en) * | 2011-04-12 | 2013-12-30 | Endocyte Inc | Solid pharmaceutical composition |
| US10080805B2 (en) | 2012-02-24 | 2018-09-25 | Purdue Research Foundation | Cholecystokinin B receptor targeting for imaging and therapy |
| EP2822386B1 (en) | 2012-02-29 | 2021-05-05 | Purdue Research Foundation | Folate receptor alpha binding ligands |
| US20140080175A1 (en) | 2012-03-29 | 2014-03-20 | Endocyte, Inc. | Processes for preparing tubulysin derivatives and conjugates thereof |
| WO2013162729A1 (en) | 2012-04-24 | 2013-10-31 | The Board Of Trustees Of The Leland Stanford Junior University | Method for delivery of small molecules and proteins across the cell wall of algae using molecular transporters |
| EP2849567B1 (en) | 2012-05-17 | 2022-03-23 | Extend Biosciences, Inc. | Carriers for improved drug delivery |
| EP2708243A1 (en) | 2012-09-17 | 2014-03-19 | OntoChem GmbH | Receptor ligand linked cytotoxic molecules |
| US20140094432A1 (en) | 2012-10-02 | 2014-04-03 | Cerulean Pharma Inc. | Methods and systems for polymer precipitation and generation of particles |
| US9662402B2 (en) | 2012-10-16 | 2017-05-30 | Endocyte, Inc. | Drug delivery conjugates containing unnatural amino acids and methods for using |
| KR102575825B1 (ko) | 2012-11-15 | 2023-09-06 | 엔도사이트, 인코포레이티드 | Psma 발현 세포에 의해 야기되는 질병을 치료하기 위한 컨쥬게이트 |
| JP6340162B2 (ja) | 2012-12-20 | 2018-06-06 | 日東電工株式会社 | アポトーシス誘導剤 |
| US20140249315A1 (en) | 2013-03-01 | 2014-09-04 | Endocyte, Inc. | Processes for preparing tubulysins |
| US9352049B2 (en) * | 2013-03-14 | 2016-05-31 | Albany Molecular Research, Inc. | Ligand-therapeutic agent conjugates, silicon-based linkers, and methods for making and using them |
| SG11201602249RA (en) | 2013-10-18 | 2016-05-30 | Deutsches Krebsforsch | Labeled inhibitors of prostate specific membrane antigen (psma), their use as imaging agents and pharmaceutical agents for the treatment of prostate cancer |
| EA035171B1 (ru) | 2013-11-14 | 2020-05-08 | Эндосайт, Инк. | Конъюгаты на основе связывающихся с psma лигандов или ингибиторов psma для позитронно-эмиссионной томографии |
| EP3865153A1 (en) | 2013-11-19 | 2021-08-18 | Purdue Research Foundation | Patient selection method for inflammation |
| US20170168074A1 (en) | 2013-11-25 | 2017-06-15 | Ontochem Gmbh | Method for diagnosing G-protein coupled receptor-related diseases |
| EP2948184B1 (en) | 2014-01-10 | 2016-03-23 | Synthon Biopharmaceuticals B.V. | Duocarmycin adcs showing improved in vivo antitumor activity |
| LT3092010T (lt) | 2014-01-10 | 2018-10-25 | Synthon Biopharmaceuticals B.V. | Metodas, skirtas gryninimui cys-sujungtų antikūno-vaisto konjugatų |
| RU2686085C2 (ru) | 2014-01-10 | 2019-04-24 | Синтон Байофармасьютикалс Б. В. | Конъюгаты антитело-лекарственное средство (adc) с дуокармицином, применяемые для лечения рака эндометрия |
| WO2015135659A1 (en) | 2014-03-14 | 2015-09-17 | Ontochem Gmbh | Receptor ligand linked cytotoxic molecules |
| JP6602034B2 (ja) | 2014-04-02 | 2019-11-06 | 日東電工株式会社 | 標的化分子およびその使用 |
| WO2015155810A1 (en) | 2014-04-07 | 2015-10-15 | Nitto Denko Corporation | Novel polymer-based hydrotropes for hydrophobic drug delivery |
| US20170182117A1 (en) * | 2014-05-28 | 2017-06-29 | Stealth Biotherapeutics Corp | Therapeutic compositions including therapeutic small molecules and uses thereof |
| JP6298716B2 (ja) | 2014-05-30 | 2018-03-20 | 日立建機株式会社 | 作業機械 |
| WO2016065052A1 (en) | 2014-10-22 | 2016-04-28 | Extend Biosciences, Inc. | Insulin vitamin d conjugates |
| JP6946182B2 (ja) | 2014-10-22 | 2021-10-06 | エクステンド バイオサイエンシズ インコーポレーテッドExtend Biosciences, Inc | 治療用ビタミンdコンジュゲート |
| US9789197B2 (en) | 2014-10-22 | 2017-10-17 | Extend Biosciences, Inc. | RNAi vitamin D conjugates |
| US10188759B2 (en) | 2015-01-07 | 2019-01-29 | Endocyte, Inc. | Conjugates for imaging |
| EP3268046A4 (en) | 2015-03-13 | 2018-11-21 | Endocyte, Inc. | Conjugates for treating diseases |
| US10406238B2 (en) | 2015-05-11 | 2019-09-10 | Purdue Research Foundation | Ligand ionophore conjugates |
| WO2017030893A1 (en) | 2015-08-14 | 2017-02-23 | Endocyte, Inc. | Method of imaging with a chelating compound |
| WO2017147240A1 (en) | 2016-02-23 | 2017-08-31 | Tarveda Therapeutics, Inc. | Hsp90 targeted conjugates and particles and formulations thereof |
| AU2017232930B2 (en) | 2016-03-16 | 2021-03-25 | ChromaDex Inc. | B-vitamin and amino acid conjugates of nicotinoyl ribosides and reduced nicotinoyl ribosides, derivatives thereof, and methods of preparation thereof |
| CN110678204A (zh) * | 2016-03-29 | 2020-01-10 | 恩多塞特公司 | 用于靶向肿瘤相关巨噬细胞的叶酸缀合物 |
| WO2017214491A1 (en) * | 2016-06-09 | 2017-12-14 | Blinkbio, Inc. | Silanol based therapeutic payloads |
| JP7096813B2 (ja) | 2016-08-26 | 2022-07-06 | エクシーバ ゲーエムベーハー | 組成物及びその方法 |
| NZ803738A (en) | 2016-11-11 | 2024-05-31 | Chromadex Inc | Efficient and scalable syntheses of nicotinoyl ribosides and reduced nicotinoyl ribosides, modified derivatives thereof, phosphorylated analogs thereof, adenylyl dinucleotide conjugates thereof, and novel crystalline forms thereof |
| US11071747B2 (en) | 2016-11-29 | 2021-07-27 | University Of Iowa Research Foundation | Use of NAD precursors for breast enhancement |
| JP7136795B2 (ja) | 2016-11-29 | 2022-09-13 | ユニバーシティー オブ アイオワ リサーチ ファウンデーション | 母体の健康および/または子の健康を向上させるためのnad前駆体の使用 |
| CA3060510A1 (en) | 2017-04-21 | 2018-10-25 | Lunella Biotech, Inc. | Vitamin c and doxycycline: a synthetic lethal combination therapy for eradicating cancer stem cells (cscs) |
| WO2018195446A1 (en) | 2017-04-21 | 2018-10-25 | Lisanti Michael P | Targeting hypoxic cancer stem cells (cscs) with doxycycline: implications for improving anti-angiogenic therapy |
| WO2018213764A1 (en) | 2017-05-19 | 2018-11-22 | Lunella Biotech, Inc. | Companion diagnostics for mitochondrial inhibitors |
| PH12019502594A1 (en) | 2017-05-19 | 2020-10-26 | Lunella Biotech Inc | Antimitoscins: targeted inhibitors of mitochondrial biogenesis for eradicating cancer stem cells |
| RU2020102908A (ru) | 2017-06-26 | 2021-07-27 | Лунелла Байотек, Инк. | Митокетосцины: митохондриальная терапия, нацеленная на кетоновый метаболизм в раковых клетках |
| WO2019084323A1 (en) | 2017-10-25 | 2019-05-02 | Georgia State University Research Foundation, Inc. | CHEMICAL RELEASE SYSTEM DELIVERED BY ENRICHMENT |
| BR112020020961A2 (pt) | 2018-04-17 | 2021-01-19 | Endocyte, Inc. | Métodos de tratamento de câncer |
| CN120097929A (zh) | 2019-05-20 | 2025-06-06 | 因多塞特股份有限公司 | 制备psma缀合物的方法 |
| DK4103236T3 (en) | 2020-10-27 | 2023-11-13 | Elucida Oncology Inc | Folate receptor targeted nanoparticle drug conjugates and uses thereof |
| MX2023013483A (es) * | 2021-05-14 | 2024-02-27 | Purdue Research Foundation | Conjugados blanco del receptor de folato con enlazadores escindibles por la enzima de la membrana en cepillo, y metodos de uso en imagenologia y tratamiento de cancer. |
| JP2025534350A (ja) | 2022-09-30 | 2025-10-15 | エクステンド バイオサイエンシズ インコーポレーテッド | 長時間作用型副甲状腺ホルモン |
Family Cites Families (133)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2515483A (en) | 1946-08-10 | 1950-07-18 | Merck & Co Inc | Diacylated pteroic acid and process for preparing same |
| US2816110A (en) | 1956-11-23 | 1957-12-10 | Merck & Co Inc | Methods for the production of substituted pteridines |
| US3392173A (en) | 1964-03-09 | 1968-07-09 | Lilly Co Eli | Novel acyl derivatives of desacetyl-vincaleukoblastine and processes for their preparation |
| US3387001A (en) | 1964-10-19 | 1968-06-04 | Lilly Co Eli | Novel aminoacyl esters of desacetyl vincaleukoblastine |
| US4203898A (en) | 1977-08-29 | 1980-05-20 | Eli Lilly And Company | Amide derivatives of VLB, leurosidine, leurocristine and related dimeric alkaloids |
| US4166810A (en) | 1978-04-20 | 1979-09-04 | Eli Lilly And Company | Derivatives of 4-desacetyl VLB C-3 carboxyhydrazide |
| US4337339A (en) | 1979-04-30 | 1982-06-29 | Baker Instruments Corp. | Process for preparation of folic acid derivatives |
| US4639456A (en) * | 1980-06-10 | 1987-01-27 | Omnichem S.A. | Vinblastin-23-oyl amino acid derivatives |
| US4316885A (en) * | 1980-08-25 | 1982-02-23 | Ayerst, Mckenna And Harrison, Inc. | Acyl derivatives of rapamycin |
| US4713249A (en) | 1981-11-12 | 1987-12-15 | Schroeder Ulf | Crystallized carbohydrate matrix for biologically active substances, a process of preparing said matrix, and the use thereof |
| US5140104A (en) | 1982-03-09 | 1992-08-18 | Cytogen Corporation | Amine derivatives of folic acid analogs |
| US4687808A (en) * | 1982-08-12 | 1987-08-18 | Biospecific Technologies, Inc. | Activation of biocompatible polymers with biologicals whose binding complements are pathological effectors |
| EP0116208B1 (en) | 1982-12-07 | 1988-03-30 | Kyowa Hakko Kogyo Co., Ltd. | Mitomycin analogues |
| GR81790B (show.php) * | 1983-04-29 | 1984-12-12 | Omnichem Sa | |
| US4866180A (en) | 1984-02-24 | 1989-09-12 | Bristol-Myers Company | Amino disulfide thiol exchange products |
| JPS60255789A (ja) | 1984-06-01 | 1985-12-17 | Kyowa Hakko Kogyo Co Ltd | マイトマイシン誘導体,その製造法および抗腫瘍剤 |
| US5266333A (en) | 1985-03-06 | 1993-11-30 | American Cyanamid Company | Water dispersible and water soluble carbohydrate polymer compositions for parenteral administration of growth hormone |
| US4650803A (en) * | 1985-12-06 | 1987-03-17 | University Of Kansas | Prodrugs of rapamycin |
| ZA873600B (en) | 1986-05-27 | 1988-12-28 | Lilly Co Eli | Immunoglobulin conjugates |
| US4801688A (en) | 1986-05-27 | 1989-01-31 | Eli Lilly And Company | Hydrazone immunoglobulin conjugates |
| DE3750846T2 (de) | 1986-08-29 | 1995-05-11 | Kyowa Hakko Kogyo Kk | Mitomycin-derivate. |
| US5120307A (en) * | 1988-06-21 | 1992-06-09 | Alcon Laboratories, Inc. | Method for injecting viscous fluid into the eye to life retinal membrane |
| US5006652A (en) | 1988-08-08 | 1991-04-09 | Eli Lilly And Company | Intermediates for antibody-vinca drug conjugates |
| US5094849A (en) | 1988-08-08 | 1992-03-10 | Eli Lilly And Company | Cytotoxic antibody conjugates of hydrazide derivatized vinca analogs via simple organic linkers |
| US5688488A (en) | 1989-04-03 | 1997-11-18 | Purdue Research Foundation | Composition and method for tumor imaging |
| US5108921A (en) | 1989-04-03 | 1992-04-28 | Purdue Research Foundation | Method for enhanced transmembrane transport of exogenous molecules |
| US5641487A (en) * | 1989-06-12 | 1997-06-24 | The Government Of The United States Of America As Represented By The Secretary Department Of Health And Human Services | Contraceptive vaccine based on alloimmunization with zona pellucida polypeptides |
| EP0457875A4 (en) | 1989-11-13 | 1993-03-03 | Xoma Corporation | Chimeric mouse-human a10 antibody with specificity to a human tumor cell antigen |
| US5627165A (en) * | 1990-06-13 | 1997-05-06 | Drug Innovation & Design, Inc. | Phosphorous prodrugs and therapeutic delivery systems using same |
| US5998603A (en) * | 1994-09-29 | 1999-12-07 | Isis Pharmaceuticals, Inc. | 4'-desmethyl nucleoside analogs, and oligomers thereof |
| WO1992003569A1 (en) | 1990-08-29 | 1992-03-05 | Centre Hospitalier Regional De Nantes | Protein polyligands joined to a stable protein core |
| US5378696A (en) * | 1990-09-19 | 1995-01-03 | American Home Products Corporation | Rapamycin esters |
| US5221670A (en) * | 1990-09-19 | 1993-06-22 | American Home Products Corporation | Rapamycin esters |
| US5130307A (en) | 1990-09-28 | 1992-07-14 | American Home Products Corporation | Aminoesters of rapamycin |
| US5233036A (en) * | 1990-10-16 | 1993-08-03 | American Home Products Corporation | Rapamycin alkoxyesters |
| US5120842A (en) * | 1991-04-01 | 1992-06-09 | American Home Products Corporation | Silyl ethers of rapamycin |
| US5100883A (en) * | 1991-04-08 | 1992-03-31 | American Home Products Corporation | Fluorinated esters of rapamycin |
| US5118678A (en) * | 1991-04-17 | 1992-06-02 | American Home Products Corporation | Carbamates of rapamycin |
| US5194447A (en) * | 1992-02-18 | 1993-03-16 | American Home Products Corporation | Sulfonylcarbamates of rapamycin |
| US5138051A (en) * | 1991-08-07 | 1992-08-11 | American Home Products Corporation | Rapamycin analogs as immunosuppressants and antifungals |
| US5118677A (en) | 1991-05-20 | 1992-06-02 | American Home Products Corporation | Amide esters of rapamycin |
| US5169851A (en) * | 1991-08-07 | 1992-12-08 | American Home Products Corporation | Rapamycin analog as immunosuppressants and antifungals |
| US6335434B1 (en) | 1998-06-16 | 2002-01-01 | Isis Pharmaceuticals, Inc., | Nucleosidic and non-nucleosidic folate conjugates |
| US5151413A (en) * | 1991-11-06 | 1992-09-29 | American Home Products Corporation | Rapamycin acetals as immunosuppressant and antifungal agents |
| US5159079A (en) | 1991-12-20 | 1992-10-27 | Eli Lilly And Company | 2-piperidones as intermediates for 5-deaza-10-oxo- and 5-deaza-10-thio-5,6,7,8-tetrahydrofolic acids |
| US6004555A (en) | 1992-03-05 | 1999-12-21 | Board Of Regents, The University Of Texas System | Methods for the specific coagulation of vasculature |
| US5302584A (en) * | 1992-10-13 | 1994-04-12 | American Home Products Corporation | Carbamates of rapamycin |
| US5258389A (en) * | 1992-11-09 | 1993-11-02 | Merck & Co., Inc. | O-aryl, O-alkyl, O-alkenyl and O-alkynylrapamycin derivatives |
| US5260300A (en) * | 1992-11-19 | 1993-11-09 | American Home Products Corporation | Rapamycin carbonate esters as immuno-suppressant agents |
| EP1181938B1 (en) | 1993-04-23 | 2007-11-14 | Wyeth | Rapamycin conjugates and antibodies |
| US5391730A (en) * | 1993-10-08 | 1995-02-21 | American Home Products Corporation | Phosphorylcarbamates of rapamycin and oxime derivatives thereof |
| US5385908A (en) * | 1993-11-22 | 1995-01-31 | American Home Products Corporation | Hindered esters of rapamycin |
| US5385909A (en) * | 1993-11-22 | 1995-01-31 | American Home Products Corporation | Heterocyclic esters of rapamycin |
| US5385910A (en) * | 1993-11-22 | 1995-01-31 | American Home Products Corporation | Gem-distributed esters of rapamycin |
| US5389639A (en) * | 1993-12-29 | 1995-02-14 | American Home Products Company | Amino alkanoic esters of rapamycin |
| US5417982A (en) | 1994-02-17 | 1995-05-23 | Modi; Pankaj | Controlled release of drugs or hormones in biodegradable polymer microspheres |
| IL112873A (en) | 1994-03-08 | 2005-03-20 | Wyeth Corp | Rapamycin-fkbp12 binding proteins, their isolation and their use |
| US6171859B1 (en) | 1994-03-30 | 2001-01-09 | Mitokor | Method of targeting conjugate molecules to mitochondria |
| US5362718A (en) * | 1994-04-18 | 1994-11-08 | American Home Products Corporation | Rapamycin hydroxyesters |
| US5463048A (en) * | 1994-06-14 | 1995-10-31 | American Home Products Corporation | Rapamycin amidino carbamates |
| US5574018A (en) * | 1994-07-29 | 1996-11-12 | Amgen Inc. | Conjugates of vitamin B12 and proteins |
| US5491231A (en) * | 1994-11-28 | 1996-02-13 | American Home Products Corporation | Hindered N-oxide esters of rapamycin |
| US5547668A (en) | 1995-05-05 | 1996-08-20 | The Board Of Trustees Of The University Of Illinois | Conjugates of folate anti-effector cell antibodies |
| US6207157B1 (en) | 1996-04-23 | 2001-03-27 | The United States Of America As Represented By The Department Of Health And Human Services | Conjugate vaccine for nontypeable Haemophilus influenzae |
| US6030941A (en) * | 1996-05-01 | 2000-02-29 | Avi Biopharma, Inc. | Polymer composition for delivering substances in living organisms |
| CA2253904A1 (en) * | 1996-05-03 | 1997-11-13 | Immunomedics, Inc. | Targeted combination immunotherapy of cancer |
| DE19621133A1 (de) | 1996-05-24 | 1997-11-27 | Boehringer Mannheim Gmbh | Bestimmungsverfahren mit oligomerisierten Rezeptoren |
| WO1998010651A1 (en) | 1996-09-12 | 1998-03-19 | Merck & Co., Inc. | Conjugates useful in the treatment of prostate cancer |
| US6056973A (en) | 1996-10-11 | 2000-05-02 | Sequus Pharmaceuticals, Inc. | Therapeutic liposome composition and method of preparation |
| US6071532A (en) | 1996-10-15 | 2000-06-06 | Emory University | Synthesis of glycophospholipid and peptide-phospholipid conjugates and uses thereof |
| US6177404B1 (en) | 1996-10-15 | 2001-01-23 | Merck & Co., Inc. | Conjugates useful in the treatment of benign prostatic hyperplasia |
| US6291673B1 (en) | 1997-10-17 | 2001-09-18 | Purdue Research Foundation | Folic acid derivatives |
| GB9723669D0 (en) | 1997-11-07 | 1998-01-07 | Univ Aberdeen | Skin penetration enhancing components |
| US6380395B1 (en) | 1998-04-21 | 2002-04-30 | Bristol-Myers Squibb Company | 12, 13-cyclopropane epothilone derivatives |
| US6093382A (en) | 1998-05-16 | 2000-07-25 | Bracco Research Usa Inc. | Metal complexes derivatized with folate for use in diagnostic and therapeutic applications |
| EP1079859B1 (en) * | 1998-05-22 | 2010-07-14 | The Board Of Trustees Of The Leland Stanford Junior University | Bifunctional molecules and therapies based thereon |
| EP1140022B8 (en) | 1998-12-18 | 2008-10-15 | Hadasit Medical Research Services & Development Ltd. | Method of administering a compound to multi-drug resistant cells |
| US6291684B1 (en) | 1999-03-29 | 2001-09-18 | Bristol-Myers Squibb Company | Process for the preparation of aziridinyl epothilones from oxiranyl epothilones |
| IL146055A0 (en) | 1999-04-23 | 2002-07-25 | Alza Corp | Conjugate having a cleavable linkage for use in a liposome |
| AUPQ014799A0 (en) * | 1999-05-04 | 1999-05-27 | Access Pharmaceuticals Australia Pty Limited | Amplification of folate-mediated targeting to tumor cells using polymers |
| AUPQ071299A0 (en) * | 1999-06-02 | 1999-06-24 | Access Pharmaceuticals Australia Pty Limited | Vitamin directed dual targeting therapy |
| JP2003507438A (ja) * | 1999-08-24 | 2003-02-25 | セルゲイト, インコーポレイテッド | オリゴアルギニン部分を使用する上皮組織を横切るおよび上皮組織内への薬物送達の増強 |
| JP2003512338A (ja) * | 1999-10-15 | 2003-04-02 | メイオウ・フアウンデーシヨン・フオー・メデイカル・エジユケイシヨン・アンド・リサーチ | 造影剤および抗腫瘍薬として有用なコバラミン結合体 |
| US7067111B1 (en) * | 1999-10-25 | 2006-06-27 | Board Of Regents, University Of Texas System | Ethylenedicysteine (EC)-drug conjugates, compositions and methods for tissue specific disease imaging |
| EA005823B1 (ru) | 2000-03-31 | 2005-06-30 | Пердью Рисерч Фаундейшн | Способ лечения с использованием конъюгатов лиганд-иммуноген |
| US6670355B2 (en) | 2000-06-16 | 2003-12-30 | Wyeth | Method of treating cardiovascular disease |
| CN100448487C (zh) | 2000-08-11 | 2009-01-07 | 惠氏公司 | 治疗雌激素受体阳性癌的方法 |
| ATE411321T1 (de) | 2000-09-19 | 2008-10-15 | Wyeth Corp | Wasserlösliche rapamycin-ester |
| US6399625B1 (en) | 2000-09-27 | 2002-06-04 | Wyeth | 1-oxorapamycins |
| US6399626B1 (en) | 2000-10-02 | 2002-06-04 | Wyeth | Hydroxyesters of 7-desmethylrapamycin |
| US6440991B1 (en) | 2000-10-02 | 2002-08-27 | Wyeth | Ethers of 7-desmethlrapamycin |
| MXPA03004688A (es) | 2000-11-28 | 2003-09-05 | Wyeth Corp | Analisis de expresion de acidos nucleicos y polipeptidos fkbp utiles en diagnostico. |
| AR036993A1 (es) | 2001-04-02 | 2004-10-20 | Wyeth Corp | Uso de agentes que modulan la interaccion entre pd-1 y sus ligandos en la submodulacion de respuestas inmunologicas |
| EP2388590A1 (en) | 2001-04-02 | 2011-11-23 | Dana Farber Cancer Institute | PD-1, a receptor for B7-4, and uses thereof |
| EP1389209B1 (en) | 2001-04-24 | 2009-04-08 | Purdue Research Foundation | Folate mimetics and folate-receptor binding conjugates thereof |
| CN1635910A (zh) * | 2001-05-02 | 2005-07-06 | 普渡研究基金会 | 巨噬细胞介导的疾病的治疗和诊断 |
| US7109165B2 (en) | 2001-05-18 | 2006-09-19 | Sirna Therapeutics, Inc. | Conjugates and compositions for cellular delivery |
| WO2002098868A1 (en) | 2001-06-01 | 2002-12-12 | Bristol-Myers Squibb Company | Epothilone derivatives |
| US20040018203A1 (en) | 2001-06-08 | 2004-01-29 | Ira Pastan | Pegylation of linkers improves antitumor activity and reduces toxicity of immunoconjugates |
| UA77200C2 (en) | 2001-08-07 | 2006-11-15 | Wyeth Corp | Antineoplastic combination of cci-779 and bkb-569 |
| BR0211905A (pt) | 2001-08-22 | 2004-09-21 | Wyeth Corp | Dialdeìdos de rapamicina |
| WO2003018573A1 (en) | 2001-08-22 | 2003-03-06 | Wyeth | Rapamycin 29-enols |
| EP1434603B1 (en) | 2001-09-28 | 2009-12-16 | Purdue Research Foundation | Method of treatment using ligand-immunogen conjugates |
| GR1004163B (el) | 2001-11-01 | 2003-02-21 | Πολυκυκλικα παραγωγα τροποποιησης των οπτικων ιδιοτητων και των ιδιοτητων αντοχης στο πλασμα των πολυμερων λιθογραφιας | |
| US8043602B2 (en) | 2002-02-07 | 2011-10-25 | Endocyte, Inc. | Folate targeted enhanced tumor and folate receptor positive tissue optical imaging technology |
| US7000695B2 (en) | 2002-05-02 | 2006-02-21 | Halliburton Energy Services, Inc. | Expanding wellbore junction |
| ES2500922T3 (es) * | 2002-05-06 | 2014-10-01 | Endocyte, Inc. | Agentes de formación de imágenes dirigidos al receptor de folato |
| US6596757B1 (en) * | 2002-05-14 | 2003-07-22 | Immunogen Inc. | Cytotoxic agents comprising polyethylene glycol-containing taxanes and their therapeutic use |
| ES2324708T3 (es) * | 2002-05-15 | 2009-08-13 | Endocyte, Inc. | Conjugados de vitamina-mitomicina. |
| EP1523493B1 (de) | 2002-07-09 | 2013-09-04 | Dömling, Alexander | Neue tubulysinanaloga |
| EP1575518A4 (en) | 2002-10-10 | 2007-08-22 | Wyeth Corp | COMPOSITIONS, ORGANISMS AND METHODS WITH A NEW HUMAN KINASE |
| CN1741741A (zh) | 2002-11-21 | 2006-03-01 | 惠氏公司 | 用于治疗狼疮肾炎的组合物和方法 |
| DE10254439A1 (de) | 2002-11-21 | 2004-06-03 | GESELLSCHAFT FüR BIOTECHNOLOGISCHE FORSCHUNG MBH (GBF) | Tubulysine, Herstellungsverfahren und Tubulysin-Mittel |
| EP1592457B1 (en) * | 2003-01-27 | 2012-07-25 | Endocyte, Inc. | Folate-vinblastine conjugate as medicament |
| AR042938A1 (es) | 2003-02-06 | 2005-07-06 | Wyeth Corp | Uso del cci-779 en el tratamiento de la fibrosis hepatica |
| CA2522637C (en) | 2003-04-17 | 2014-01-21 | Alnylam Pharmaceuticals, Inc. | Modified irna agents |
| WO2004101803A2 (en) | 2003-05-12 | 2004-11-25 | Wyeth Holdings Corporation | Process for producing anticancer agent ll-d45042 |
| WO2005010010A1 (en) | 2003-07-16 | 2005-02-03 | Wyeth | Cci-779 isomer c |
| WO2005016935A2 (en) | 2003-08-07 | 2005-02-24 | Wyeth | Regioselective synthesis of cci-779 |
| US8288557B2 (en) | 2004-07-23 | 2012-10-16 | Endocyte, Inc. | Bivalent linkers and conjugates thereof |
| WO2006020768A2 (en) | 2004-08-10 | 2006-02-23 | Alnylam Pharmaceuticals, Inc. | Chemically modified oligonucleotides |
| CN101175757B (zh) | 2005-03-16 | 2012-11-14 | 恩多塞特公司 | 蝶酸及其缀合物的合成和纯化 |
| AU2006230219A1 (en) | 2005-03-30 | 2006-10-05 | Endocyte, Inc. | Method for cancer prognosis using cellular folate vitamin receptor quantification |
| WO2007006041A2 (en) | 2005-07-05 | 2007-01-11 | Purdue Research Foundation | Imaging and therapeutic method using monocytes |
| CN103893779A (zh) | 2005-08-19 | 2014-07-02 | 恩多塞特公司 | 多药物配体缀合物 |
| EP1948240A2 (en) | 2005-08-19 | 2008-07-30 | Endocyte, Inc. | Ligand conjugates of vinca alkaloids, analogs and derivatives |
| PE20080102A1 (es) | 2006-05-25 | 2008-02-11 | Bristol Myers Squibb Co | Conjugados de analogos de aziridinil-epotilona y composiciones farmaceuticas que comprenden los mismos |
| TW200841476A (en) | 2007-02-16 | 2008-10-16 | Mears Technologies Inc | Multiple-wavelength opto-electronic device including a superlattice and associated methods |
| US20100104626A1 (en) | 2007-02-16 | 2010-04-29 | Endocyte, Inc. | Methods and compositions for treating and diagnosing kidney disease |
| CN101678124A (zh) | 2007-03-14 | 2010-03-24 | 恩多塞特公司 | 结合配体连接的微管溶素递药缀合物 |
| US9877965B2 (en) * | 2007-06-25 | 2018-01-30 | Endocyte, Inc. | Vitamin receptor drug delivery conjugates for treating inflammation |
| CN104383553A (zh) * | 2007-06-25 | 2015-03-04 | 恩多塞特公司 | 含有亲水性间隔区接头的共轭物 |
| CA2737496A1 (en) * | 2008-09-17 | 2010-03-25 | Endocyte, Inc. | Folate receptor binding conjugates of antifolates |
-
2004
- 2004-01-27 EP EP04705573A patent/EP1592457B1/en not_active Expired - Lifetime
- 2004-01-27 EP EP12004279A patent/EP2517729A3/en not_active Withdrawn
- 2004-01-27 WO PCT/US2004/002070 patent/WO2004069159A2/en not_active Ceased
- 2004-01-27 AR ARP040100241A patent/AR042942A1/es not_active Application Discontinuation
- 2004-01-27 TW TW101108172A patent/TWI405573B/zh not_active IP Right Cessation
- 2004-01-27 PT PT04705573T patent/PT1592457E/pt unknown
- 2004-01-27 AU AU2004210136A patent/AU2004210136C1/en not_active Ceased
- 2004-01-27 EP EP12004281A patent/EP2517730A3/en not_active Withdrawn
- 2004-01-27 DK DK04705573.6T patent/DK1592457T3/da active
- 2004-01-27 NZ NZ541846A patent/NZ541846A/en not_active IP Right Cessation
- 2004-01-27 JP JP2005518938A patent/JP5576007B2/ja not_active Expired - Fee Related
- 2004-01-27 US US10/765,336 patent/US7601332B2/en not_active Expired - Fee Related
- 2004-01-27 ES ES04705573T patent/ES2395082T3/es not_active Expired - Lifetime
- 2004-01-27 TW TW093101735A patent/TWI367096B/zh not_active IP Right Cessation
- 2004-01-27 CA CA2512867A patent/CA2512867C/en not_active Expired - Fee Related
- 2004-01-27 TW TW102113366A patent/TWI492750B/zh not_active IP Right Cessation
- 2004-01-27 EP EP12004280A patent/EP2529758A3/en not_active Withdrawn
-
2005
- 2005-06-30 IL IL169469A patent/IL169469A/en not_active IP Right Cessation
-
2009
- 2009-07-10 US US12/501,283 patent/US8105568B2/en not_active Expired - Fee Related
-
2010
- 2010-12-22 JP JP2010286329A patent/JP4815009B2/ja not_active Expired - Fee Related
-
2011
- 2011-07-28 JP JP2011165553A patent/JP5721580B2/ja not_active Expired - Fee Related
- 2011-09-07 US US13/199,654 patent/US20120065149A1/en not_active Abandoned
-
2012
- 2012-10-25 CY CY20121101011T patent/CY1113258T1/el unknown
-
2013
- 2013-03-05 US US13/785,523 patent/US20140058063A1/en not_active Abandoned
-
2014
- 2014-12-04 JP JP2014246193A patent/JP2015078215A/ja not_active Withdrawn
-
2015
- 2015-05-21 IL IL238935A patent/IL238935A0/en unknown
- 2015-08-26 US US14/836,255 patent/US20160220694A1/en not_active Abandoned
-
2018
- 2018-03-26 US US15/936,393 patent/US20190216934A9/en not_active Abandoned
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2011102304A5 (show.php) | ||
| JP2012255026A5 (show.php) | ||
| JP2013509429A5 (show.php) | ||
| JP2013518107A5 (show.php) | ||
| CY1121781T1 (el) | Φαρμακοτεχνικες μορφες παρατεταμενης απελευθερωσης της ρασαγιλινης και χρησεις αυτων | |
| JP2016536286A5 (show.php) | ||
| JP2017524735A5 (show.php) | ||
| JP2012532874A5 (show.php) | ||
| JP2016501221A5 (show.php) | ||
| JP2015078230A5 (show.php) | ||
| CY1119490T1 (el) | Παραγωγα πυραζολοπυρρολιδινης και η χρηση τους στην θεραπεια νοσηματων | |
| JP2014221779A5 (show.php) | ||
| JP2012525393A5 (show.php) | ||
| JP2015536964A5 (show.php) | ||
| JP2009535352A5 (show.php) | ||
| JP2014526503A5 (show.php) | ||
| JP2016517888A5 (show.php) | ||
| JP2015532296A5 (show.php) | ||
| JP2015516419A5 (show.php) | ||
| AR083528A1 (es) | Analogos de peptido insulinotropico dependiente de glucosa | |
| JP2008535785A5 (show.php) | ||
| JP2010521516A5 (show.php) | ||
| RU2017141536A (ru) | Замещенные производные индол-5-ола и их терапевтические применения | |
| JP2011046708A5 (show.php) | ||
| JP2012508256A5 (show.php) |