JP2011051946A - 硫化水素産生酵素阻害剤 - Google Patents
硫化水素産生酵素阻害剤 Download PDFInfo
- Publication number
- JP2011051946A JP2011051946A JP2009203689A JP2009203689A JP2011051946A JP 2011051946 A JP2011051946 A JP 2011051946A JP 2009203689 A JP2009203689 A JP 2009203689A JP 2009203689 A JP2009203689 A JP 2009203689A JP 2011051946 A JP2011051946 A JP 2011051946A
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- JP
- Japan
- Prior art keywords
- hydrogen sulfide
- producing enzyme
- solution
- gallate
- catechins
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- RWSOTUBLDIXVET-UHFFFAOYSA-N Dihydrogen sulfide Chemical compound S RWSOTUBLDIXVET-UHFFFAOYSA-N 0.000 title claims abstract description 88
- 229910000037 hydrogen sulfide Inorganic materials 0.000 title claims abstract description 88
- 102000004190 Enzymes Human genes 0.000 title claims abstract description 52
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- 239000003112 inhibitor Substances 0.000 title abstract description 11
- ADRVNXBAWSRFAJ-UHFFFAOYSA-N catechin Natural products OC1Cc2cc(O)cc(O)c2OC1c3ccc(O)c(O)c3 ADRVNXBAWSRFAJ-UHFFFAOYSA-N 0.000 claims abstract description 29
- 235000005487 catechin Nutrition 0.000 claims abstract description 29
- 150000001765 catechin Chemical class 0.000 claims abstract description 22
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- 229940125532 enzyme inhibitor Drugs 0.000 claims description 15
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- LSHVYAFMTMFKBA-CTNGQTDRSA-N (-)-catechin-3-O-gallate Chemical compound O([C@@H]1CC2=C(O)C=C(C=C2O[C@H]1C=1C=C(O)C(O)=CC=1)O)C(=O)C1=CC(O)=C(O)C(O)=C1 LSHVYAFMTMFKBA-CTNGQTDRSA-N 0.000 claims description 7
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- WMBWREPUVVBILR-NQIIRXRSSA-N (-)-gallocatechin gallate Chemical compound O([C@@H]1CC2=C(O)C=C(C=C2O[C@H]1C=1C=C(O)C(O)=C(O)C=1)O)C(=O)C1=CC(O)=C(O)C(O)=C1 WMBWREPUVVBILR-NQIIRXRSSA-N 0.000 claims description 6
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Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/99—Enzyme inactivation by chemical treatment
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
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- A—HUMAN NECESSITIES
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
- A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
- A61K8/498—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom having 6-membered rings or their condensed derivatives, e.g. coumarin
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/74—Biological properties of particular ingredients
- A61K2800/78—Enzyme modulators, e.g. Enzyme agonists
- A61K2800/782—Enzyme inhibitors; Enzyme antagonists
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- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
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- Mycology (AREA)
- Nutrition Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Birds (AREA)
- Cosmetics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Non-Alcoholic Beverages (AREA)
Priority Applications (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2009203689A JP2011051946A (ja) | 2009-09-03 | 2009-09-03 | 硫化水素産生酵素阻害剤 |
KR1020127008514A KR20120073265A (ko) | 2009-09-03 | 2010-09-01 | 황화수소 산생 효소 저해제 |
CN2010800397020A CN102482662A (zh) | 2009-09-03 | 2010-09-01 | 硫化氢生成酶抑制剂 |
PCT/JP2010/005384 WO2011027551A1 (ja) | 2009-09-03 | 2010-09-01 | 硫化水素産生酵素阻害剤 |
TW099129908A TW201124135A (en) | 2009-09-03 | 2010-09-03 | Hydrogen sulfide-producing enzyme inhibitor |
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JP2009203689A JP2011051946A (ja) | 2009-09-03 | 2009-09-03 | 硫化水素産生酵素阻害剤 |
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JP2011051946A true JP2011051946A (ja) | 2011-03-17 |
JP2011051946A5 JP2011051946A5 (zh) | 2012-10-18 |
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JP (1) | JP2011051946A (zh) |
KR (1) | KR20120073265A (zh) |
CN (1) | CN102482662A (zh) |
TW (1) | TW201124135A (zh) |
WO (1) | WO2011027551A1 (zh) |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2013249263A (ja) * | 2012-05-30 | 2013-12-12 | Ajinomoto Co Inc | ガロタンニン含有組成物 |
JP2014513543A (ja) * | 2011-05-13 | 2014-06-05 | バイオジェン・アイデック・エムエイ・インコーポレイテッド | トリスルフィド結合を防止および除去する方法 |
JP2015149904A (ja) * | 2014-02-10 | 2015-08-24 | 森永乳業株式会社 | 含硫アミノ酸リアーゼ阻害剤 |
US10308706B2 (en) | 2009-10-02 | 2019-06-04 | Biogen Ma Inc. | Methods of preventing and removing trisulfide bonds |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB2497619B (en) | 2011-12-15 | 2016-04-06 | Lg Display Co Ltd | Polarization glasses type stereoscopic image display |
CN108635378B (zh) * | 2018-04-23 | 2020-01-24 | 山东大学 | 一种用于日常口腔健康维护的口腔喷剂及其制备方法 |
CN108567773B (zh) * | 2018-04-23 | 2020-04-17 | 山东大学 | 一种用于清除口臭的口腔喷剂及其制备方法 |
CN109043383A (zh) * | 2018-09-05 | 2018-12-21 | 旌德县板桥现代渔业家庭农场 | 一种醋化乌龟蛋及其制备方法 |
KR20200051452A (ko) * | 2018-11-05 | 2020-05-13 | (주)아모레퍼시픽 | 성분 함량이 변화된 녹차 추출물 |
CN116041100B (zh) * | 2023-02-24 | 2023-10-20 | 东北农业大学 | 一种降低堆肥中硫化氢释放量的方法 |
Citations (4)
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JP2004105157A (ja) * | 2002-09-20 | 2004-04-08 | Pharmafoods Kenkyusho:Kk | 糖類分解酵素阻害飲食組成物 |
JP2005082495A (ja) * | 2003-09-04 | 2005-03-31 | Pharma Foods International Co Ltd | 脳細胞保護のための組成物 |
JP2005162697A (ja) * | 2003-12-04 | 2005-06-23 | Lotte Co Ltd | メチオニナーゼ阻害剤及びそれを含有する口腔用組成物並びに飲食品 |
JP2006129757A (ja) * | 2004-11-04 | 2006-05-25 | Pharma Foods International Co Ltd | 苦味やえぐ味を低減した緑茶抽出物、及び該抽出物を含有する飲食品 |
Family Cites Families (1)
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WO2004012522A1 (en) * | 2002-07-26 | 2004-02-12 | Dsm Ip Assets B.V. | Compositions comprising lactoferrin |
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- 2010-09-01 WO PCT/JP2010/005384 patent/WO2011027551A1/ja active Application Filing
- 2010-09-01 CN CN2010800397020A patent/CN102482662A/zh active Pending
- 2010-09-01 KR KR1020127008514A patent/KR20120073265A/ko not_active Application Discontinuation
- 2010-09-03 TW TW099129908A patent/TW201124135A/zh unknown
Patent Citations (4)
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JP2004105157A (ja) * | 2002-09-20 | 2004-04-08 | Pharmafoods Kenkyusho:Kk | 糖類分解酵素阻害飲食組成物 |
JP2005082495A (ja) * | 2003-09-04 | 2005-03-31 | Pharma Foods International Co Ltd | 脳細胞保護のための組成物 |
JP2005162697A (ja) * | 2003-12-04 | 2005-06-23 | Lotte Co Ltd | メチオニナーゼ阻害剤及びそれを含有する口腔用組成物並びに飲食品 |
JP2006129757A (ja) * | 2004-11-04 | 2006-05-25 | Pharma Foods International Co Ltd | 苦味やえぐ味を低減した緑茶抽出物、及び該抽出物を含有する飲食品 |
Non-Patent Citations (2)
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JPN6010057622; 菊池紗奈恵他: '口臭に関与する口腔内細菌由来粗酵素に対する緑茶カテキン類の阻害効果' 口腔衛生会誌 Vol.59, No.4, 20090830, p.391 * |
JPN6010057623; ZHU M. et al.: 'Effect of Tea Polyphenols on Growth and H2S Production of Halitosis Causing Bacteria' Abstracts of the General Meeting of the American Society for Microbiology Vol.103, 2003, p.226, #D-133 * |
Cited By (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US10308706B2 (en) | 2009-10-02 | 2019-06-04 | Biogen Ma Inc. | Methods of preventing and removing trisulfide bonds |
JP2014513543A (ja) * | 2011-05-13 | 2014-06-05 | バイオジェン・アイデック・エムエイ・インコーポレイテッド | トリスルフィド結合を防止および除去する方法 |
US9562252B2 (en) | 2011-05-13 | 2017-02-07 | Biogen Ma Inc. | Methods of preventing and removing trisulfide bonds |
US9790533B2 (en) | 2011-05-13 | 2017-10-17 | Biogen Ma Inc. | Methods of preventing and removing trisulfide bonds |
US10590454B2 (en) | 2011-05-13 | 2020-03-17 | Biogen Ma Inc. | Methods of preventing and removing trisulfide bonds |
JP2013249263A (ja) * | 2012-05-30 | 2013-12-12 | Ajinomoto Co Inc | ガロタンニン含有組成物 |
JP2015149904A (ja) * | 2014-02-10 | 2015-08-24 | 森永乳業株式会社 | 含硫アミノ酸リアーゼ阻害剤 |
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WO2011027551A1 (ja) | 2011-03-10 |
TW201124135A (en) | 2011-07-16 |
CN102482662A (zh) | 2012-05-30 |
KR20120073265A (ko) | 2012-07-04 |
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