JP2011032235A - 液状口腔用組成物 - Google Patents
液状口腔用組成物 Download PDFInfo
- Publication number
- JP2011032235A JP2011032235A JP2009181483A JP2009181483A JP2011032235A JP 2011032235 A JP2011032235 A JP 2011032235A JP 2009181483 A JP2009181483 A JP 2009181483A JP 2009181483 A JP2009181483 A JP 2009181483A JP 2011032235 A JP2011032235 A JP 2011032235A
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- JP
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- Prior art keywords
- oral composition
- liquid oral
- mass
- liquid
- gum
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
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Abstract
【解決手段】特定量のキサンタンガムとマンナン誘導体を特定比率で含有させることにより、口腔内細菌の歯牙表面や歯周組織表面への付着を効果的に防止し歯垢の形成を防止することで齲蝕や歯周病を予防することができ、さらには無機電解質を配合することで液性が改善し、優れた液状口腔用組成物。
【選択図】なし
Description
項1.キサンタンガム(A)およびガラクトマンナン多糖類(B)を含有する組成物においてAの配合量が0.05〜0.3質量%、Bの配合量が0.05〜0.3質量%であり、AとBの配合量の比率が3:1〜1:3であることを特徴とする液状口腔用組成物。
項2.ガラクトマンナン多糖類が、グアガムおよびローカストビーンガムから選ばれる1種以上であることを特徴とする項1に記載の液状口腔用組成物。
項3.組成物の粘度が、150mPa・s以下であることを特徴とする項1または項2の何れかに記載の液状口腔用組成物。
項4.さらに水溶性金属塩を0.05〜0.5質量%配合したことを特徴とする項1〜3に記載の液状口腔用組成物。
項5.カチオン性殺菌剤を含有しないことを特徴とする項1〜4何れかに記載の液状口腔用組成物。
campestris)の発酵により得られるキサンタンガムは、化粧料や医薬品分野で通常使用されているものであれば、特に限定されない。配合量は0.05〜0.3質量%であり、好ましくは0.05〜0.2質量%、さらに好ましくは0.05〜0.15質量%である。
96穴プレートにBHI−S(BHI, 50g/L スクロース)に100μLずつ分注した後、調製した被検サンプル100μLを添加し、さらにStreptococcus mutans菌液を100μL添加し、振盪撹拌した後に、35℃、嫌気下で24時間培養する。培養後、培地を除去し、各ウェルを200μL蒸留水で1回洗浄し、0.1%クリスタルバイオレット液を各ウェルに50μL加えて15分間静置し、さらに200μLの蒸留水で洗浄を2回行なった後に、99%エタノールを各ウェルに200μL加え、15分間振盪して得られた抽出液のOD590吸光度を測定する。ポジティブントロール(以下、「PC」と略する。)は被検サンプルの代わりにBHI−Sを添加し、ネガティブコントロール(以下、「NC」と略する。)は菌液を添加せずにBHI−Sのみを添加したものを用いた。なお、測定は各条件で3検体実施した。
付着阻害率は、下記の数式に従って計算し、得られた計算値の平均値を算出した。
◎ 付着阻害率 75%以上
○ 付着阻害率 60%以上75%未満
× 付着阻害率 60%未満
粘度測定は、E型粘度計を用い、No.42ローター、25℃、20r.p.m.、60秒の条件で行なった。
容器に入れたサンプルの外観性状を目視にて判断する。十分な流動性があり液体状のものを◎、流動性はあるが粘稠液状のものを○とした。
常法に従って、液体歯磨剤を調製した。
成分 配合量(質量%)
ソルビット 10.0
ポリオキシエチレン硬化ヒマシ油(60EO) 0.5
キサンタンガム 0.15
グアガム(A) 0.2
香料 0.05
サッカリンナトリウム 0.01
リン酸ナトリウム 0.05
酢酸トコフェロール 0.02
精製水 残部
合計 100.0
常法に従って、洗口剤を調製した。
成分 配合量(質量%)
エタノール 10.0
グリセリン 5.0
キサンタンガム 0.05
グアガム(B) 0.05
クエン酸 0.01
クエン酸ナトリウム 0.1
ポリオキシエチレン硬化ヒマシ油(60EO) 0.5
パラオキシ安息香酸メチル 0.1
香料 0.2
ビタミンE 0.05
ビタミンC 0.01
精製水 残部
合計 100.0
常法に従って、塗布剤を調製した。
成分 配合量(質量%)
セラック 10.0
エチルアルコール 40.0
キサンタンガム 0.1
タラガム 0.1
フッ化ナトリウム 0.2
香料 1.5
精製水 残部
合計 100.0
常法に従って、洗口剤を調製した。
成分 配合量(質量%)
グリセリン 15.0
ポリオキシエチレン硬化ヒマシ油(60EO) 0.5
ポリエチレングリコール400 3.0
キサンタンガム 0.1
ローカストビーンガム 0.05
香料 0.1
サッカリンナトリウム 0.01
リン酸ナトリウム 0.05
精製水 残部
合計 100.0
常法に従って、液体歯磨を調製した。
成分 配合量(質量%)
ソルビット 10.0
ポリオキシエチレン硬化ヒマシ油(40EO) 5.0
ポリエチレングリコール400 5.0
キサンタンガム 0.3
グアガム(A) 0.1
香料 0.05
スクラロース 0.01
トリクロサン 0.05
塩化ナトリウム 0.3
酢酸トコフェロール 0.02
精製水 残部
合計 100.0
Claims (4)
- キサンタンガム(A)およびガラクトマンナン多糖類(B)を含有する組成物においてAの配合量が0.05〜0.3質量%、Bの配合量が0.05〜0.3質量%であり、AとBの配合量の比率が3:1〜1:3であることを特徴とする液状口腔用組成物。
- ガラクトマンナン多糖類が、グアガムおよびローカストビーンガムから選ばれる1種以上であることを特徴とする請求項1に記載の液状口腔用組成物。
- 組成物の粘度が、150mPa・s以下であることを特徴とする請求項1または2の何れかに記載の液状口腔用組成物。
- さらに水溶性金属塩を0.05〜0.5質量%配合したことを特徴とする請求項1〜3に記載の液状口腔用組成物。
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JP2004300120A (ja) * | 2003-04-01 | 2004-10-28 | Sunstar Inc | 口腔用組成物 |
JP2004300119A (ja) * | 2003-04-01 | 2004-10-28 | Sunstar Inc | 口腔用組成物 |
JP2006124362A (ja) * | 2004-10-27 | 2006-05-18 | Sunstar Inc | 口腔内状態改善用組成物 |
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JP2006124362A (ja) * | 2004-10-27 | 2006-05-18 | Sunstar Inc | 口腔内状態改善用組成物 |
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