JP2010540677A5 - - Google Patents
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- Publication number
- JP2010540677A5 JP2010540677A5 JP2010528477A JP2010528477A JP2010540677A5 JP 2010540677 A5 JP2010540677 A5 JP 2010540677A5 JP 2010528477 A JP2010528477 A JP 2010528477A JP 2010528477 A JP2010528477 A JP 2010528477A JP 2010540677 A5 JP2010540677 A5 JP 2010540677A5
- Authority
- JP
- Japan
- Prior art keywords
- electron withdrawing
- site
- polymer
- group
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims description 5
- 125000006575 electron-withdrawing group Chemical group 0.000 claims description 5
- 229920000642 polymer Polymers 0.000 claims description 5
- 125000005647 linker group Chemical group 0.000 claims description 3
- 229920002704 polyhistidine Polymers 0.000 claims description 3
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 3
- 108090000623 proteins and genes Proteins 0.000 claims description 3
- 102000004169 proteins and genes Human genes 0.000 claims description 3
- 125000004450 alkenylene group Chemical group 0.000 claims 2
- 125000002947 alkylene group Chemical group 0.000 claims 2
- 125000004432 carbon atom Chemical group C* 0.000 claims 2
- 125000004429 atom Chemical group 0.000 claims 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 1
- 125000005843 halogen group Chemical group 0.000 description 2
- 229910052801 chlorine Inorganic materials 0.000 description 1
- 125000001309 chloro group Chemical group Cl* 0.000 description 1
- 229910052731 fluorine Inorganic materials 0.000 description 1
- 125000001153 fluoro group Chemical group F* 0.000 description 1
- 125000003107 substituted aryl group Chemical group 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP07253992 | 2007-10-09 | ||
| EP07253992.7 | 2007-10-09 | ||
| GB0813339.9 | 2008-07-21 | ||
| GB0813339A GB0813339D0 (en) | 2008-07-21 | 2008-07-21 | Novel reagents and method for conjugating biological molecules |
| PCT/GB2008/003409 WO2009047500A1 (en) | 2007-10-09 | 2008-10-08 | Novel conjugated proteins and peptides |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016040039A Division JP6250083B2 (ja) | 2007-10-09 | 2016-03-02 | 新規な複合タンパク質及びペプチド |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010540677A JP2010540677A (ja) | 2010-12-24 |
| JP2010540677A5 true JP2010540677A5 (enExample) | 2016-04-28 |
| JP5933923B2 JP5933923B2 (ja) | 2016-06-22 |
Family
ID=40225449
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010528477A Expired - Fee Related JP5933923B2 (ja) | 2007-10-09 | 2008-10-08 | 新規な複合タンパク質及びペプチド |
| JP2016040039A Expired - Fee Related JP6250083B2 (ja) | 2007-10-09 | 2016-03-02 | 新規な複合タンパク質及びペプチド |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016040039A Expired - Fee Related JP6250083B2 (ja) | 2007-10-09 | 2016-03-02 | 新規な複合タンパク質及びペプチド |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US20100239517A1 (enExample) |
| EP (1) | EP2209494B1 (enExample) |
| JP (2) | JP5933923B2 (enExample) |
| KR (1) | KR20100090684A (enExample) |
| CN (1) | CN101820920B (enExample) |
| BR (1) | BRPI0818288A2 (enExample) |
| DK (1) | DK2209494T3 (enExample) |
| ES (1) | ES2597849T3 (enExample) |
| WO (1) | WO2009047500A1 (enExample) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0316294D0 (en) | 2003-07-11 | 2003-08-13 | Polytherics Ltd | Conjugated biological molecules and their preparation |
| DK2101821T3 (da) | 2006-12-15 | 2014-10-06 | Baxter Healthcare Sa | Faktor VIIA-(poly)sialinsyre-konjugat med forlænget halveringstid in vivo |
| ES2560807T3 (es) | 2008-07-21 | 2016-02-22 | Polytherics Limited | Nuevos reactivos y procedimiento de conjugación de moléculas biológicas |
| EP2350118B1 (en) | 2008-09-19 | 2016-03-30 | Nektar Therapeutics | Carbohydrate-based drug delivery polymers and conjugates thereof |
| US20110206633A1 (en) * | 2008-09-19 | 2011-08-25 | Nektar Therapectics | Polymer conjugates of cd-np peptides |
| GB0922354D0 (en) | 2009-12-21 | 2010-02-03 | Polytherics Ltd | Novel polymer conjugates |
| US9005598B2 (en) | 2009-03-04 | 2015-04-14 | Polytherics Limited | Conjugated proteins and peptides |
| GB0912485D0 (en) | 2009-07-17 | 2009-08-26 | Polytherics Ltd | Improved conjugation method |
| BR112012001814A8 (pt) | 2009-07-27 | 2018-02-06 | Baxalta GmbH | Conjugados de proteína de coagulação sanguínea |
| EP3081233B1 (en) | 2009-07-27 | 2020-12-23 | Baxalta GmbH | Glycopolysialylation of proteins other than blood coagulation proteins |
| US8642737B2 (en) | 2010-07-26 | 2014-02-04 | Baxter International Inc. | Nucleophilic catalysts for oxime linkage |
| US8809501B2 (en) | 2009-07-27 | 2014-08-19 | Baxter International Inc. | Nucleophilic catalysts for oxime linkage |
| RU2744370C2 (ru) | 2009-07-27 | 2021-03-05 | Баксалта Инкорпорейтед | Конъюгаты белков свертывания крови |
| US8604127B2 (en) * | 2009-10-29 | 2013-12-10 | Korea Advanced Institute Of Science And Technology | Conjugate of catechol-modified polyethylene glycol with protein or peptide and preparation method thereof |
| GB201007357D0 (en) | 2010-04-30 | 2010-06-16 | Leverton Licence Holdings Ltd | Conjugated factor VIII |
| GB201007356D0 (en) | 2010-04-30 | 2010-06-16 | Leverton Licence Holdings Ltd | Conjugated factor VIIa |
| ES2800983T3 (es) | 2010-12-22 | 2021-01-07 | Baxalta GmbH | Materiales y métodos para conjugar un derivado de ácido graso soluble en agua con una proteína |
| JP6202707B2 (ja) * | 2011-10-13 | 2017-09-27 | 国立大学法人鳥取大学 | 新規細胞膜透過ペプチド |
| HK1200695A1 (en) | 2012-04-16 | 2015-08-14 | Cantab Biopharmaceuticals Patents Limited | Optimised subcutaneous therapeutic agents |
| GB201210770D0 (en) | 2012-06-18 | 2012-08-01 | Polytherics Ltd | Novel conjugation reagents |
| US9650331B2 (en) | 2012-06-18 | 2017-05-16 | Polytherics Limited | Conjugation reagents |
| US9441010B2 (en) * | 2012-08-08 | 2016-09-13 | Clarkson University | Method for selective derivatization of oligohistidine sequence of recombinant proteins |
| ES2885854T3 (es) | 2014-10-14 | 2021-12-15 | Polytherics Ltd | Proceso para la conjugación de un péptido o proteína con un reactivo que comprende un grupo saliente que incluye una porción de PEG |
| US10098960B2 (en) | 2015-04-03 | 2018-10-16 | Ucl Business Plc | Polymer conjugate |
| JP2019506155A (ja) | 2016-01-12 | 2019-03-07 | クレッシェンド、バイオロジックス、リミテッドＣｒｅｓｃｅｎｄｏ Ｂｉｏｌｏｇｉｃｓ Ｌｉｍｉｔｅｄ | 治療分子 |
| WO2017161206A1 (en) | 2016-03-16 | 2017-09-21 | Halozyme, Inc. | Conjugates containing conditionally active antibodies or antigen-binding fragments thereof, and methods of use |
| CN109152845B (zh) | 2016-04-14 | 2022-07-12 | 宝力泰锐克斯有限公司 | 含有在环内包含至少两个(-ch2-ch2-o-)单元的接头的缀合物和缀合试剂 |
| GB201608936D0 (en) | 2016-05-20 | 2016-07-06 | Polytherics Ltd | Novel conjugates and novel conjugating reagents |
| CN117534764A (zh) | 2016-06-06 | 2024-02-09 | 阿布泽纳(英国)有限公司 | 抗体、其用途及其缀合物 |
| GB201614162D0 (en) | 2016-08-18 | 2016-10-05 | Polytherics Ltd | Antibodies, uses thereof and conjugates thereof |
| DE102017103050B4 (de) * | 2017-02-15 | 2019-05-16 | Hoerbiger Automatisierungstechnik Holding Gmbh | Fahrwerk einer transportablen Einrichtung |
| GB201711068D0 (en) | 2017-07-10 | 2017-08-23 | Crescendo Biologics Ltd | Therapeutic molecules binding PSMA |
| WO2020188323A1 (en) * | 2019-03-18 | 2020-09-24 | Khashayar Karimian | Mate and separate: a convenient and general method for the separation and purification of target molecules from biological media by phase transition of pegylated recognition agents. |
| JP2024524109A (ja) * | 2021-06-17 | 2024-07-05 | ネクター セラピューティクス | ヒスチジン選択的ポリマー試薬 |
| CA3245384A1 (en) | 2022-03-03 | 2023-09-07 | Cambridge Enterprise Limited | Therapeutic antibodies |
| EP4556907B1 (en) * | 2023-11-20 | 2026-02-04 | Miltenyi Biotec B.V. & Co. KG | Site-specific conjugation of single domain antibody fragments (vhh) using equilibrium transfer alkylation reagent (etac) |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1340522C (en) * | 1987-03-10 | 1999-05-04 | Heinz Dobeli | Fusion proteins containing neighbouring histidines for improved purification |
| US6552170B1 (en) * | 1990-04-06 | 2003-04-22 | Amgen Inc. | PEGylation reagents and compounds formed therewith |
| EP0991944B1 (en) * | 1997-06-25 | 2004-08-25 | N.V. Innogenetics S.A. | Methods for covalent immobilisation of biomolecules to a carrier by means of a his-tag |
| US5985263A (en) * | 1997-12-19 | 1999-11-16 | Enzon, Inc. | Substantially pure histidine-linked protein polymer conjugates |
| FR2778918B1 (fr) * | 1998-05-25 | 2000-07-21 | Commissariat Energie Atomique | Baton moleculaire et ses applications |
| DK1656952T3 (da) * | 1998-10-16 | 2014-01-20 | Biogen Idec Inc | Polyalkylenglycolkonjugater af interferon beta-1A og anvendelser deraf |
| GB0316294D0 (en) * | 2003-07-11 | 2003-08-13 | Polytherics Ltd | Conjugated biological molecules and their preparation |
-
2008
- 2008-10-08 US US12/682,057 patent/US20100239517A1/en not_active Abandoned
- 2008-10-08 BR BRPI0818288 patent/BRPI0818288A2/pt not_active Application Discontinuation
- 2008-10-08 KR KR1020107010204A patent/KR20100090684A/ko not_active Ceased
- 2008-10-08 CN CN200880110579.XA patent/CN101820920B/zh not_active Expired - Fee Related
- 2008-10-08 WO PCT/GB2008/003409 patent/WO2009047500A1/en not_active Ceased
- 2008-10-08 EP EP08806549.5A patent/EP2209494B1/en not_active Not-in-force
- 2008-10-08 DK DK08806549.5T patent/DK2209494T3/en active
- 2008-10-08 JP JP2010528477A patent/JP5933923B2/ja not_active Expired - Fee Related
- 2008-10-08 ES ES08806549.5T patent/ES2597849T3/es active Active
-
2016
- 2016-03-02 JP JP2016040039A patent/JP6250083B2/ja not_active Expired - Fee Related