JP2010540638A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2010540638A5 JP2010540638A5 JP2010527996A JP2010527996A JP2010540638A5 JP 2010540638 A5 JP2010540638 A5 JP 2010540638A5 JP 2010527996 A JP2010527996 A JP 2010527996A JP 2010527996 A JP2010527996 A JP 2010527996A JP 2010540638 A5 JP2010540638 A5 JP 2010540638A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- haloalkyl
- alkyl
- optionally substituted
- halogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000001424 substituent group Chemical group 0.000 claims 31
- 229910052736 halogen Inorganic materials 0.000 claims 30
- 150000002367 halogens Chemical class 0.000 claims 30
- 125000001188 haloalkyl group Chemical group 0.000 claims 24
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 23
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 21
- -1 cyano, hydroxy Chemical group 0.000 claims 20
- 239000008194 pharmaceutical composition Substances 0.000 claims 20
- 125000004093 cyano group Chemical group *C#N 0.000 claims 19
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 claims 17
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 16
- 125000004737 (C1-C6) haloalkoxy group Chemical group 0.000 claims 16
- 125000000217 alkyl group Chemical group 0.000 claims 13
- 125000004438 haloalkoxy group Chemical group 0.000 claims 12
- 125000001072 heteroaryl group Chemical group 0.000 claims 12
- 125000004890 (C1-C6) alkylamino group Chemical group 0.000 claims 11
- 125000006619 (C1-C6) dialkylamino group Chemical group 0.000 claims 11
- 125000003118 aryl group Chemical group 0.000 claims 11
- 125000004454 (C1-C6) alkoxycarbonyl group Chemical group 0.000 claims 10
- 125000000171 (C1-C6) haloalkyl group Chemical group 0.000 claims 10
- 125000003545 alkoxy group Chemical group 0.000 claims 10
- 125000004916 (C1-C6) alkylcarbonyl group Chemical group 0.000 claims 9
- 125000003282 alkyl amino group Chemical group 0.000 claims 9
- 125000004448 alkyl carbonyl group Chemical group 0.000 claims 9
- 125000004663 dialkyl amino group Chemical group 0.000 claims 9
- 125000004453 alkoxycarbonyl group Chemical group 0.000 claims 7
- 150000003839 salts Chemical class 0.000 claims 6
- 150000001875 compounds Chemical class 0.000 claims 5
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 5
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 5
- 125000001931 aliphatic group Chemical group 0.000 claims 4
- 125000006615 aromatic heterocyclic group Chemical group 0.000 claims 4
- 229910052739 hydrogen Inorganic materials 0.000 claims 4
- 239000001257 hydrogen Substances 0.000 claims 4
- 125000004435 hydrogen atom Chemical class [H]* 0.000 claims 4
- 208000030761 polycystic kidney disease Diseases 0.000 claims 4
- 125000000008 (C1-C10) alkyl group Chemical group 0.000 claims 3
- 125000002947 alkylene group Chemical group 0.000 claims 3
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims 3
- 125000006832 (C1-C10) alkylene group Chemical group 0.000 claims 2
- 125000002393 azetidinyl group Chemical group 0.000 claims 2
- 125000006161 haloaliphatic group Chemical group 0.000 claims 2
- 125000004193 piperazinyl group Chemical group 0.000 claims 2
- 125000003386 piperidinyl group Chemical group 0.000 claims 2
- 125000000719 pyrrolidinyl group Chemical group 0.000 claims 2
- 125000006527 (C1-C5) alkyl group Chemical group 0.000 claims 1
- 125000004203 4-hydroxyphenyl group Chemical group [H]OC1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
- 208000010061 Autosomal Dominant Polycystic Kidney Diseases 0.000 claims 1
- 125000003277 amino group Chemical group 0.000 claims 1
- 230000001548 androgenic effect Effects 0.000 claims 1
- 208000022185 autosomal dominant polycystic kidney disease Diseases 0.000 claims 1
- 125000002757 morpholinyl group Chemical group 0.000 claims 1
- 229910052757 nitrogen Inorganic materials 0.000 claims 1
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 1
- 125000003107 substituted aryl group Chemical group 0.000 claims 1
- 238000006467 substitution reaction Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US99780307P | 2007-10-05 | 2007-10-05 | |
| US60/997,803 | 2007-10-05 | ||
| PCT/US2008/011450 WO2009045503A1 (en) | 2007-10-05 | 2008-10-03 | Method of treating polycystic kidney diseases with ceramide derivatives |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013209652A Division JP2014024858A (ja) | 2007-10-05 | 2013-10-04 | セラミド誘導体を用いる多発性嚢胞腎疾患の治療方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010540638A JP2010540638A (ja) | 2010-12-24 |
| JP2010540638A5 true JP2010540638A5 (enExample) | 2011-11-17 |
| JP5896601B2 JP5896601B2 (ja) | 2016-03-30 |
Family
ID=40108810
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010527996A Expired - Fee Related JP5896601B2 (ja) | 2007-10-05 | 2008-10-03 | セラミド誘導体を用いる多発性嚢胞腎疾患の治療方法 |
| JP2013209652A Pending JP2014024858A (ja) | 2007-10-05 | 2013-10-04 | セラミド誘導体を用いる多発性嚢胞腎疾患の治療方法 |
| JP2015249968A Withdrawn JP2016041761A (ja) | 2007-10-05 | 2015-12-22 | セラミド誘導体を用いる多発性嚢胞腎疾患の治療方法 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013209652A Pending JP2014024858A (ja) | 2007-10-05 | 2013-10-04 | セラミド誘導体を用いる多発性嚢胞腎疾患の治療方法 |
| JP2015249968A Withdrawn JP2016041761A (ja) | 2007-10-05 | 2015-12-22 | セラミド誘導体を用いる多発性嚢胞腎疾患の治療方法 |
Country Status (14)
| Country | Link |
|---|---|
| US (3) | US8912177B2 (enExample) |
| EP (2) | EP2550965B1 (enExample) |
| JP (3) | JP5896601B2 (enExample) |
| KR (3) | KR20150085139A (enExample) |
| CN (2) | CN102940627A (enExample) |
| AU (1) | AU2008307516B2 (enExample) |
| BR (2) | BRPI0817864A2 (enExample) |
| CA (1) | CA2701649C (enExample) |
| ES (1) | ES2660690T3 (enExample) |
| IL (1) | IL204741A (enExample) |
| MX (2) | MX337396B (enExample) |
| RU (2) | RU2517345C9 (enExample) |
| SG (2) | SG184721A1 (enExample) |
| WO (1) | WO2009045503A1 (enExample) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BRPI0517701A8 (pt) | 2004-11-10 | 2018-01-23 | Genzyme Corp | métodos de tratamento de diabetes mellitus |
| US8716327B2 (en) | 2006-05-09 | 2014-05-06 | Genzyme Corporation | Methods of treating fatty liver disease |
| EP2594565B1 (en) * | 2007-05-31 | 2018-10-24 | Genzyme Corporation | 2-acylaminopropanol-type glucosylceramide synthase inhibitors |
| CN102940627A (zh) | 2007-10-05 | 2013-02-27 | 简詹姆公司 | 使用脑酰胺衍生物治疗多囊性肾疾病的方法 |
| CA2731685A1 (en) | 2008-07-28 | 2010-02-04 | Genzyme Corporation | Glucosylceramide synthase inhibition for the treatment of collapsing glomerulopathy and other glomerular disease |
| MX2011003517A (es) * | 2008-10-03 | 2011-05-25 | Genzyme Corp | Inhibidores de la glucosilceramida sintasa tipo 2-acilaminopropanol. |
| WO2013059119A1 (en) * | 2011-10-17 | 2013-04-25 | The Regents Of The University Of Michigan | Glucosylceramide synthase inhibitors and therapeutic methods using the same |
| AU2013305759C1 (en) | 2012-08-23 | 2018-01-18 | Janssen Biopharma, Inc. | Compounds for the treatment of paramoxyvirus viral infections |
| EP2968268B1 (en) | 2013-03-15 | 2020-07-29 | Concert Pharmaceuticals Inc. | Inhibitors of the enzyme udp-glucose: n-acyl-sphingosine glucosyltransferase |
| SG11201600977XA (en) | 2013-08-21 | 2016-03-30 | Alios Biopharma Inc | Antiviral compounds |
| US9457016B2 (en) | 2013-08-29 | 2016-10-04 | New York University | Methods for treating polycystic kidney disease |
| CN110372636B (zh) | 2013-09-20 | 2023-03-28 | 生物马林药物股份有限公司 | 用于治疗疾病的葡萄糖神经酰胺合成酶抑制剂 |
| SI3063141T1 (sl) | 2013-10-29 | 2018-11-30 | Biomarin Pharmaceutical Inc. | N-(1-hidroksi-3-(pirolidinil)propan-2-il)pirolidin-3-karboksamidni derivati kot inhibitorji glukozilceramid sintaze |
| CN115322089B (zh) * | 2022-07-18 | 2023-10-03 | 中国农业科学院烟草研究所(中国烟草总公司青州烟草研究所) | 一种覆盆子酮半抗原、人工抗原及其制备方法、抗体和应用 |
Family Cites Families (77)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1555654A (en) * | 1977-06-25 | 1979-11-14 | Exxon Research Engineering Co | Agricultural burner apparatus |
| US4065562A (en) * | 1975-12-29 | 1977-12-27 | Nippon Shinyaku Co., Ltd. | Method and composition for reducing blood glucose levels |
| NO154918C (no) * | 1977-08-27 | 1987-01-14 | Bayer Ag | Analogifremgangsmaate til fremstilling av terapeutisk aktive derivater av 3,4,5-trihydroksypiperidin. |
| GB2020278B (en) * | 1978-05-03 | 1983-02-23 | Nippon Shinyaku Co Ltd | Moranoline dervitives |
| JPS568318A (en) | 1979-06-28 | 1981-01-28 | Janssen Pharmaceutica Nv | Non oral long acting composition of haloperidol and bromperidol derivative |
| GB8311286D0 (en) | 1983-04-26 | 1983-06-02 | Searle & Co | Carboxyalkyl peptide derivatives |
| EP0144290A3 (de) | 1983-12-01 | 1987-05-27 | Ciba-Geigy Ag | Substituierte Aethylendiaminderivate |
| US5041441A (en) | 1988-04-04 | 1991-08-20 | The Regents Of The University Of Michigan | Method of chemotherapy using 1-phenyl-2-decanoylamino-3-morpholino-1-propanol |
| US5302609A (en) * | 1992-12-16 | 1994-04-12 | The Regents Of The University Of Michigan | Treatment of diabetic nephropathy |
| US5399567A (en) * | 1993-05-13 | 1995-03-21 | Monsanto Company | Method of treating cholera |
| JP3778926B2 (ja) | 1993-08-13 | 2006-05-24 | 生化学工業株式会社 | 神経疾患治療剤 |
| PT742789E (pt) | 1994-02-02 | 2000-12-29 | Liposome Co Inc | Lipossomas e compostos farmaceuticamente activos e metodos para a sua utilizacao |
| DE69524592T2 (de) | 1994-06-10 | 2002-07-18 | Seikagaku Corp., Tokio/Tokyo | 2-Acylaminopropanolverbindung und ihre pharmazeutische Zusammensetzung |
| US6890949B1 (en) | 1999-07-09 | 2005-05-10 | The Regents Of The University Of Michigan | Amino ceramide-like compounds and therapeutic methods of use |
| WO2001004108A1 (en) | 1999-07-09 | 2001-01-18 | Regents Of The University Of Michigan | Amino ceramide-like compounds and therapeutic methods of use |
| US5916911A (en) | 1995-09-20 | 1999-06-29 | The Regents Of The University Of Michigan | Amino ceramide--like compounds and therapeutic methods of use |
| US20030073680A1 (en) | 1995-09-20 | 2003-04-17 | The Regents Of The University Of Michigan | Amino ceramide-like compounds and therapeutic methods of use |
| US6255336B1 (en) * | 1995-09-20 | 2001-07-03 | The Regents Of The University Of Michigan | Amino ceramide-like compounds and therapeutic methods of use |
| JP3993908B2 (ja) | 1995-12-08 | 2007-10-17 | 生化学工業株式会社 | アミノアルコール誘導体及び該誘導体の製造方法 |
| NO965193L (no) | 1995-12-08 | 1997-06-09 | Seikagaku Kogyo Kk Seikagaku C | Aminalkoholderivat og fremgangsmåte for fremstilling derav |
| JP4140984B2 (ja) | 1995-12-20 | 2008-08-27 | 生化学工業株式会社 | 分化誘導作用を有する薬剤 |
| JP2871565B2 (ja) | 1995-12-26 | 1999-03-17 | 株式会社神戸製鋼所 | ローラヘッド押出機とその制御方法 |
| US5972928A (en) * | 1997-05-21 | 1999-10-26 | Johns Hopkins University | Methods for treatment of conditions associated with lactosylceramide |
| JP4036500B2 (ja) | 1997-05-23 | 2008-01-23 | 生化学工業株式会社 | アミノアルコール誘導体及びそれを含有する医薬 |
| JP4176170B2 (ja) | 1997-06-06 | 2008-11-05 | 生化学工業株式会社 | アミノアルコール誘導体を含む医薬及び異常増殖性疾患治療薬 |
| US6465488B1 (en) * | 1997-12-11 | 2002-10-15 | Chancellor, Masters & Scholars Of The University Of Oxford | Inhibition of glycolipid biosynthesis |
| ES2285852T3 (es) | 1998-07-27 | 2007-11-16 | Johns Hopkins University | Compuestos de diamino-propanol para el tratamiento de la isquemia. |
| US6610703B1 (en) * | 1998-12-10 | 2003-08-26 | G.D. Searle & Co. | Method for treatment of glycolipid storage diseases |
| GB0100889D0 (en) * | 2001-01-12 | 2001-02-21 | Oxford Glycosciences Uk Ltd | Compounds |
| BR0012318A (pt) * | 1999-07-09 | 2002-05-28 | Univ Michigan | Compostos semelhantes a amino ceramida e métodos terapêuticos de uso |
| JP5009459B2 (ja) | 1999-12-06 | 2012-08-22 | 生化学工業株式会社 | アミノアルコール誘導体及びそれを含有する医薬 |
| US6407064B2 (en) * | 1999-12-06 | 2002-06-18 | Seikagaku Corporation | Aminoalcohol derivative and medicament comprising the same |
| US6235737B1 (en) | 2000-01-25 | 2001-05-22 | Peter Styczynski | Reduction of hair growth |
| PL357674A1 (pl) | 2000-04-19 | 2004-07-26 | Thomas Julius Borody | Kompozycje i sposoby leczenia zaburzeń związanychz hiperlipidemią |
| AU2002241724A1 (en) | 2000-12-20 | 2002-07-01 | Bristol-Myers Squibb Company | Diamines as modulators of chemokine receptor activity |
| US7365197B2 (en) | 2000-12-29 | 2008-04-29 | Wyeth | Method for the regioselective preparation of substituted benzo[g]quinoline-3-carbonitriles and benzo[g]quinazolines |
| US20020198240A1 (en) | 2001-01-10 | 2002-12-26 | Shayman James A. | Amino ceramide - like compounds and therapeutic methods of use |
| US7148251B2 (en) | 2001-01-10 | 2006-12-12 | The Regents Of The University Of Michigan | Amino ceramide-like compounds and therapeutic methods of use |
| CA2434028C (en) | 2001-01-10 | 2010-11-09 | The Regents Of The University Of Michigan | Amino ceramide-like compounds and therapeutic methods of use |
| US20040260099A1 (en) | 2001-01-10 | 2004-12-23 | The Regents Of The University Of Michigan | Amino ceramide-like compounds and therapeutic methods of use |
| ATE555102T1 (de) * | 2001-07-16 | 2012-05-15 | Genzyme Corp | N-acylsphingosinglucosyltransferase-inhibitor |
| WO2003045928A1 (en) | 2001-11-26 | 2003-06-05 | Genzyme Corporation | Diastereoselective synthesis of udp-glucose : n-acylsphingosine glucosyltransferase inhibitors |
| GB0229931D0 (en) | 2002-12-21 | 2003-01-29 | Astrazeneca Ab | Therapeutic agents |
| WO2003057874A1 (fr) | 2001-12-28 | 2003-07-17 | Sumitomo Pharmaceuticals Company, Limited | Marqueurs de maladies pour maladies renales et leur utilisation |
| MEP46108A (en) | 2002-01-22 | 2011-02-10 | Warner Lambert Co | 2-(PYRIDIN-2-YLAMINO)-PYRIDO[2,3d]PYRIMIDIN-7-ONES |
| EP1336411A1 (en) | 2002-02-14 | 2003-08-20 | Academisch Medisch Centrum bij de Universiteit van Amsterdam | Compositions and methods for improving enzyme replacement therapy of lysosomal storage diseases |
| JP2003238410A (ja) | 2002-02-21 | 2003-08-27 | Seibutsu Yuki Kagaku Kenkyusho:Kk | インスリン抵抗性解除剤 |
| US6916802B2 (en) * | 2002-04-29 | 2005-07-12 | Genzyme Corporation | Amino ceramide-like compounds and therapeutic methods of use |
| US20060217560A1 (en) | 2002-04-29 | 2006-09-28 | Shayman James A | Amino ceramide-like compounds and therapeutic methods of use |
| WO2004007453A1 (en) | 2002-07-17 | 2004-01-22 | Oxford Glycosciences (Uk) Ltd | Piperidinetriol derivatives as inhibitors of glycosylceramide synthase |
| CN1681527A (zh) | 2002-07-17 | 2005-10-12 | 比奥根艾迪克Ma公司 | 使用干扰素－β治疗肾衰竭 |
| WO2004078194A1 (en) | 2003-02-28 | 2004-09-16 | Intermune, Inc. | Interferon drug therapy for the treatment of viral diseases and liver fibrosis |
| GB0313678D0 (en) * | 2003-06-13 | 2003-07-16 | Oxford Glycosciences Uk Ltd | Novel compounds |
| EP1528056A1 (en) * | 2003-10-29 | 2005-05-04 | Academisch Ziekenhuis bij de Universiteit van Amsterdam | Deoxynojirimycin analogues and their uses as glucosylceramidase inhibitors |
| AU2004283631A1 (en) | 2003-10-29 | 2005-05-06 | Genzyme Corporation | Use of a deoxynojirimycin derivative or a pharmaceutically salt thereof |
| US20070270350A1 (en) | 2003-12-23 | 2007-11-22 | Musc Foundation For Research Development | Methods and Compositions for the Prevention and Treatment of Inflammatory Diseases or Conditions |
| GB0400812D0 (en) | 2004-01-14 | 2004-02-18 | Celltech R&D Ltd | Novel compounds |
| EP1576894A1 (en) | 2004-03-16 | 2005-09-21 | Nederlandse Organisatie voor toegepast-natuurwetenschappelijk Onderzoek TNO | The use of sphingolipids in the treatment and prevention of type 2 diabetes mellitus, insulin resistance and Metabolic Syndrome |
| ATE500752T1 (de) | 2004-03-16 | 2011-03-15 | Tno | Verwendung von sphingolipiden bei der behandlung und vorbeugung von typ-2-diabetes mellitus, insulinresistenz und metabolismussyndrom |
| US20070224200A1 (en) | 2004-05-07 | 2007-09-27 | Samer Elbawab | Gm3 Synthase as a Therapeutic Target in Microvascular Complications of Diabetes |
| ZA200700024B (en) * | 2004-05-26 | 2008-06-25 | Fasgen Llc | Novel compounds, pharmaceutical compositions containing same, and methods of use for same |
| US20090111812A1 (en) | 2004-06-14 | 2009-04-30 | Musc Foundation For Research Development | Methods for treating inflammatory disorders |
| CA2581173A1 (en) | 2004-08-20 | 2006-03-02 | The Johns Hopkins University | Methods for treatment of angiogenesis |
| BRPI0517701A8 (pt) | 2004-11-10 | 2018-01-23 | Genzyme Corp | métodos de tratamento de diabetes mellitus |
| US8013000B2 (en) | 2005-01-26 | 2011-09-06 | Allergan, Inc. | 3-heteroaryl-3-hydroxy-2-amino-propyl amines and related compounds having analgesic and/or immuno stimlant activity |
| US8389472B2 (en) | 2005-08-19 | 2013-03-05 | Amylin Pharmaceuticals, Llc | Exendin-4 to treat nonalcoholic steatohepatitis and nonalcoholic fatty liver disease |
| US8716327B2 (en) | 2006-05-09 | 2014-05-06 | Genzyme Corporation | Methods of treating fatty liver disease |
| WO2008011478A2 (en) | 2006-07-19 | 2008-01-24 | Allergan, Inc. | Methods for treating chronic pain using 3-aryl-3-hydroxy-2-amino-propionic acid amides, 3-heteroaryl-3-hydroxy-2-amino-propionic acid amides and related compounds |
| WO2008011487A2 (en) | 2006-07-19 | 2008-01-24 | Allergan, Inc. | L-benzyl-l-hydr0xy-2, 3-diamin0-propyl amines and 3-benzyl-3-hydroxy-2-amino-propionicacid amides for chronic pain |
| GB0614947D0 (en) | 2006-07-27 | 2006-09-06 | Isis Innovation | Epitope reduction therapy |
| TWI389895B (zh) | 2006-08-21 | 2013-03-21 | Infinity Discovery Inc | 抑制ｂｃｌ蛋白質與結合夥伴間之交互作用的化合物及方法 |
| JP2010518097A (ja) | 2007-02-09 | 2010-05-27 | アイアールエム・リミテッド・ライアビリティ・カンパニー | チャネル活性化プロテアーゼ阻害剤としての化合物および組成物 |
| EP2594565B1 (en) | 2007-05-31 | 2018-10-24 | Genzyme Corporation | 2-acylaminopropanol-type glucosylceramide synthase inhibitors |
| CN102940627A (zh) | 2007-10-05 | 2013-02-27 | 简詹姆公司 | 使用脑酰胺衍生物治疗多囊性肾疾病的方法 |
| WO2009117150A2 (en) | 2008-03-20 | 2009-09-24 | Genzyme Corporation | Method of treating lupus with ceramide derivatives |
| CA2731685A1 (en) * | 2008-07-28 | 2010-02-04 | Genzyme Corporation | Glucosylceramide synthase inhibition for the treatment of collapsing glomerulopathy and other glomerular disease |
| MX2011003517A (es) * | 2008-10-03 | 2011-05-25 | Genzyme Corp | Inhibidores de la glucosilceramida sintasa tipo 2-acilaminopropanol. |
-
2008
- 2008-10-03 CN CN2012104075563A patent/CN102940627A/zh active Pending
- 2008-10-03 AU AU2008307516A patent/AU2008307516B2/en not_active Ceased
- 2008-10-03 EP EP12007327.5A patent/EP2550965B1/en not_active Not-in-force
- 2008-10-03 CA CA2701649A patent/CA2701649C/en not_active Expired - Fee Related
- 2008-10-03 EP EP08835678.7A patent/EP2209473B1/en not_active Not-in-force
- 2008-10-03 CN CN2008801192139A patent/CN101888840A/zh active Pending
- 2008-10-03 MX MX2012003498A patent/MX337396B/es unknown
- 2008-10-03 JP JP2010527996A patent/JP5896601B2/ja not_active Expired - Fee Related
- 2008-10-03 KR KR1020157018509A patent/KR20150085139A/ko not_active Ceased
- 2008-10-03 RU RU2010117585/15A patent/RU2517345C9/ru not_active IP Right Cessation
- 2008-10-03 KR KR1020107009935A patent/KR101640263B1/ko not_active Expired - Fee Related
- 2008-10-03 SG SG2012065983A patent/SG184721A1/en unknown
- 2008-10-03 BR BRPI0817864-0A patent/BRPI0817864A2/pt not_active Application Discontinuation
- 2008-10-03 KR KR1020167018039A patent/KR20160085917A/ko not_active Ceased
- 2008-10-03 MX MX2010003603A patent/MX2010003603A/es active IP Right Grant
- 2008-10-03 ES ES08835678.7T patent/ES2660690T3/es active Active
- 2008-10-03 WO PCT/US2008/011450 patent/WO2009045503A1/en not_active Ceased
- 2008-10-03 BR BRPI0823522-8A2A patent/BRPI0823522A2/pt not_active Application Discontinuation
- 2008-10-03 SG SG10201707161PA patent/SG10201707161PA/en unknown
- 2008-10-03 US US12/681,291 patent/US8912177B2/en not_active Expired - Fee Related
-
2010
- 2010-03-25 IL IL204741A patent/IL204741A/en active IP Right Grant
-
2013
- 2013-10-04 JP JP2013209652A patent/JP2014024858A/ja active Pending
-
2014
- 2014-01-29 RU RU2014102885/15A patent/RU2014102885A/ru not_active Application Discontinuation
- 2014-11-04 US US14/532,432 patent/US20150216872A1/en not_active Abandoned
-
2015
- 2015-12-22 JP JP2015249968A patent/JP2016041761A/ja not_active Withdrawn
-
2017
- 2017-01-25 US US15/414,838 patent/US10220039B2/en not_active Expired - Fee Related
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2010540638A5 (enExample) | ||
| JP2011529500A5 (enExample) | ||
| JP2018087232A5 (enExample) | ||
| RU2010117585A (ru) | Способ лечения поликистозных заболеваний почек с помощью производных церамида | |
| RU2010116253A (ru) | Производные n-гидроксилсульфонамида как новые физиологически применимые доноры нитроксила | |
| RU2011117028A (ru) | Ингибиторы глюкозилцерамидсинтазы 2-ациламинопропанольного типа | |
| JP2008530099A5 (enExample) | ||
| RU2009115963A (ru) | Производные оксадиазола, обладающие противовоспалительными и иммунодепрессантными свойствами | |
| BRPI0707491B8 (pt) | compostos úteis como agentes moduladores de receptores de mineralocorticóides, os referidos agentes compreendendo os mesmos e composições farmacêuticas | |
| JP2012504608A5 (enExample) | ||
| CY1112997T1 (el) | ΝΕΑ ΠΑΡΑΓΩΓΑ ΙΜΙΔΑΖΟ[1,5-α]ΠΥΡΙΔΙΝΩΝ, Η ΔΙΑΔΙΚΑΣIΑ ΠΑΡΑΣΚΕΥΗΣ ΤΟΥΣ ΚΑΙ ΟΙ ΦΑΡΜΑΚΕΥΤΙΚΕΣ ΣΥΝΘΕΣΕΙΣ ΠΟΥ ΤΑ ΠΕΡΙΕΧΟΥΝ | |
| WO2003074091A3 (en) | Near infrared fluorescent contrast agent and method for fluorescence imaging | |
| PE20010632A1 (es) | Derivados de ter-butil-(7-metil-imidazol[1,2-a]piridin-3-il)-amina, procedimiento para su preparacion, medicamentos y composiciones farmaceuticas que los contienen | |
| EA201490580A1 (ru) | Пирролбензодиазепины и их конъюгаты | |
| TW200745058A (en) | MMP-13 selective inhibitors | |
| AR049277A1 (es) | Compuestos para inhibir l a progresion mitotica | |
| JP2008525416A5 (enExample) | ||
| JP2008508360A5 (enExample) | ||
| WO2003057688A3 (en) | Oxo or oxy-pyridine compounds as 5-ht4 receptor modulators | |
| AR036875A1 (es) | Acidos hidroxamicos ciclicos como inhibidores de las metaloproteinasas de matriz y/o de la enzima de conversion del factor de necrosis de tumor alfa | |
| AR081426A1 (es) | Derivados de pirazol inhibidores del receptor sigma | |
| HUP9901403A1 (hu) | Új benzotiofén-, benzofurán- és indolszármazékok, eljárás előállításukra, valamint ezeket tartalmazó gyógyszerkészítmények | |
| RU2004122094A (ru) | Производные азаиндолилалкиламина и применение указанных соединений в качестве лигандов 5-гидрокситриптамина-6 | |
| TW200612920A (en) | Novel imidazolidine derivatives | |
| HRP20080542T3 (en) | (poly) aminoacetamide derivatives of epipodophyllotoxin, their process of preparation and their applications in therapeutics as anticancer agents |