JP2010540453A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2010540453A5 JP2010540453A5 JP2010526011A JP2010526011A JP2010540453A5 JP 2010540453 A5 JP2010540453 A5 JP 2010540453A5 JP 2010526011 A JP2010526011 A JP 2010526011A JP 2010526011 A JP2010526011 A JP 2010526011A JP 2010540453 A5 JP2010540453 A5 JP 2010540453A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- antibody
- targeting moiety
- interferon
- linker comprises
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 claims 25
- 230000008685 targeting Effects 0.000 claims 10
- 102000014150 Interferons Human genes 0.000 claims 8
- 108010050904 Interferons Proteins 0.000 claims 8
- 229940079322 interferon Drugs 0.000 claims 8
- 206010028980 Neoplasm Diseases 0.000 claims 7
- 125000003275 alpha amino acid group Chemical group 0.000 claims 6
- 201000011510 cancer Diseases 0.000 claims 6
- 150000001413 amino acids Chemical class 0.000 claims 4
- 239000000427 antigen Substances 0.000 claims 3
- 102000036639 antigens Human genes 0.000 claims 3
- 108091007433 antigens Proteins 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 3
- 108020004707 nucleic acids Proteins 0.000 claims 3
- 150000007523 nucleic acids Chemical class 0.000 claims 3
- 102000039446 nucleic acids Human genes 0.000 claims 3
- 238000004519 manufacturing process Methods 0.000 claims 2
- 125000000539 amino acid group Chemical group 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000013612 plasmid Substances 0.000 claims 1
- 108090000765 processed proteins & peptides Proteins 0.000 claims 1
- 230000035755 proliferation Effects 0.000 claims 1
- 229960004641 rituximab Drugs 0.000 claims 1
- 239000000439 tumor marker Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US99471707P | 2007-09-21 | 2007-09-21 | |
| US60/994,717 | 2007-09-21 | ||
| PCT/US2008/077074 WO2009039409A1 (en) | 2007-09-21 | 2008-09-19 | Targeted interferon demonstrates potent apoptotic and anti-tumor activities |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014154820A Division JP6087871B2 (ja) | 2007-09-21 | 2014-07-30 | ターゲティング化インターフェロンは強力なアポトーシス活性および抗腫瘍活性を示す |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010540453A JP2010540453A (ja) | 2010-12-24 |
| JP2010540453A5 true JP2010540453A5 (OSRAM) | 2011-11-10 |
| JP5591701B2 JP5591701B2 (ja) | 2014-09-17 |
Family
ID=40468388
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010526011A Active JP5591701B2 (ja) | 2007-09-21 | 2008-09-19 | 強力なアポトーシス活性および抗腫瘍活性を示すターゲティング化インターフェロン |
| JP2014154820A Expired - Fee Related JP6087871B2 (ja) | 2007-09-21 | 2014-07-30 | ターゲティング化インターフェロンは強力なアポトーシス活性および抗腫瘍活性を示す |
| JP2016215048A Pending JP2017031215A (ja) | 2007-09-21 | 2016-11-02 | ターゲティング化インターフェロンは強力なアポトーシス活性および抗腫瘍活性を示す |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014154820A Expired - Fee Related JP6087871B2 (ja) | 2007-09-21 | 2014-07-30 | ターゲティング化インターフェロンは強力なアポトーシス活性および抗腫瘍活性を示す |
| JP2016215048A Pending JP2017031215A (ja) | 2007-09-21 | 2016-11-02 | ターゲティング化インターフェロンは強力なアポトーシス活性および抗腫瘍活性を示す |
Country Status (12)
| Country | Link |
|---|---|
| US (5) | US9139634B2 (OSRAM) |
| EP (3) | EP2200634B1 (OSRAM) |
| JP (3) | JP5591701B2 (OSRAM) |
| KR (2) | KR101661770B1 (OSRAM) |
| CN (3) | CN103880965B (OSRAM) |
| AU (1) | AU2008302111B2 (OSRAM) |
| BR (1) | BRPI0817108B8 (OSRAM) |
| CA (1) | CA2699944C (OSRAM) |
| ES (1) | ES2536772T3 (OSRAM) |
| IL (2) | IL204644A (OSRAM) |
| MX (2) | MX2010003099A (OSRAM) |
| WO (1) | WO2009039409A1 (OSRAM) |
Families Citing this family (91)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2565834T3 (es) | 2007-06-01 | 2016-04-07 | University Of Maryland, Baltimore | Agentes de unión a receptor de Fc de región constante de inmunoglobulina |
| US20090304719A1 (en) | 2007-08-22 | 2009-12-10 | Patrick Daugherty | Activatable binding polypeptides and methods of identification and use thereof |
| MX2010003099A (es) * | 2007-09-21 | 2010-05-17 | Univ California | Interferon de objetivo demuestra actividades potentes apoptoticas y antitumorales. |
| CA2749339A1 (en) | 2009-01-12 | 2010-07-15 | Cytomx Therapeutics, Llc | Modified antibody compositions, methods of making and using thereof |
| RU2011138951A (ru) | 2009-02-23 | 2013-03-27 | Сайтомкс Терапьютикс, Инк. | Пропротеины и способы их применения |
| KR20140015152A (ko) * | 2009-12-02 | 2014-02-06 | 악셀레론 파마 인코포레이티드 | Fc 융합 단백질의 혈청 반감기를 증가시키는 조성물들 및 방법들 |
| JP2013538042A (ja) * | 2010-06-16 | 2013-10-10 | ユニバーシティ オブ ピッツバーグ − オブ ザ コモンウェルス システム オブ ハイヤー エデュケイション | エンドプラスミンに対する抗体およびその使用 |
| KR102066996B1 (ko) | 2010-07-28 | 2020-01-17 | 글리크닉 인코포레이티드 | 순차적으로 다중화된 면역글로불린 fc 조성물을 제조하기 위한 천연 인간 단백질 단편들의 융합 단백질 |
| TW201302793A (zh) | 2010-09-03 | 2013-01-16 | Glaxo Group Ltd | 新穎之抗原結合蛋白 |
| WO2012097313A2 (en) | 2011-01-14 | 2012-07-19 | The Regents Of The University Of California | Therapeutic antibodies against ror-1 protein and methods for use of same |
| US9534056B2 (en) | 2011-06-06 | 2017-01-03 | Immungene Inc | Engineered TAA antibody-TNFSF member ligand fusion molecules |
| EP2718328A4 (en) * | 2011-06-08 | 2014-12-24 | Acceleron Pharma Inc | COMPOSITIONS AND METHODS FOR INCREASING THE HALF TIME OF SERUM |
| WO2013059885A2 (en) | 2011-10-28 | 2013-05-02 | Cephalon Australia Pty Ltd | Polypeptide constructs and uses thereof |
| US8961971B2 (en) | 2011-12-22 | 2015-02-24 | Development Center For Biotechnology | Bispecific T-cell activator antibody |
| CA2861927C (en) | 2012-01-20 | 2021-01-26 | Vib Vzw | Targeted mutant alpha-helical bundle cytokines |
| EP3799880A3 (en) * | 2012-03-03 | 2021-06-23 | ImmunGene, Inc. | Engineered antibody-interferon mutant fusion molecules |
| ES2938182T3 (es) | 2012-04-30 | 2023-04-05 | Biocon Ltd | Proteínas de fusión dirigidas/inmunomoduladoras y métodos de preparación de las mismas |
| CN107759686A (zh) | 2012-05-30 | 2018-03-06 | 中外制药株式会社 | 靶组织特异性抗原结合分子 |
| CN103505722B (zh) * | 2012-06-19 | 2016-04-13 | 苏州丁孚靶点生物技术有限公司 | 干扰素在治疗/预防对常规抗肿瘤疗法有抗性的肿瘤中的用途及相关的产品和方法 |
| US9783589B2 (en) * | 2012-08-13 | 2017-10-10 | Immungene Inc | Engineered antibody-interferon fusion molecules for treatment of autoimmune diseases |
| KR20150058236A (ko) * | 2012-08-20 | 2015-05-28 | 글리크닉 인코포레이티드 | 항원 결합 및 다가 fc 감마 수용체 결합 활성을 가진 분자 |
| WO2014089354A1 (en) * | 2012-12-07 | 2014-06-12 | The Regents Of The University Of California | Cd138-targeted interferon demonstrates potent apoptotic and anti-tumor activities |
| EP2970512B1 (en) | 2013-03-12 | 2018-10-10 | Biocon Limited | Fusion immunomodulatory proteins and methods for making same |
| US11117975B2 (en) | 2013-04-29 | 2021-09-14 | Teva Pharmaceuticals Australia Pty Ltd | Anti-CD38 antibodies and fusions to attenuated interferon alpha-2B |
| EP2992013B1 (en) | 2013-04-29 | 2019-12-04 | Teva Pharmaceuticals Australia Pty Ltd | Anti-cd38 antibodies and fusions to attenuated interferon alpha-2b |
| US10093745B2 (en) | 2013-05-29 | 2018-10-09 | The Regents Of The University Of California | Anti-CSPG4 fusions with interferon for the treatment of malignancy |
| CN112225817B (zh) | 2013-07-11 | 2025-02-25 | 斯克利普斯研究所 | 卷曲螺旋免疫球蛋白融合蛋白及其组合物 |
| CN110835376B (zh) | 2013-07-18 | 2023-08-04 | 弗拉芒区生物技术研究所 | 涉及具有强烈降低的受体结合亲和力的细胞因子的融合因子 |
| WO2015007903A1 (en) | 2013-07-19 | 2015-01-22 | Vib Vzw | Targeted modified tnf family members |
| SG11201600167SA (en) | 2013-07-19 | 2016-02-26 | Vib Vzw | Targeted modified il-1 family members |
| AU2014292355B2 (en) | 2013-07-19 | 2019-08-01 | Centre Hospitalier Regional Universitaire De Montpellier | Targeting of cytokine antagonists |
| US11446516B2 (en) | 2013-08-09 | 2022-09-20 | The Trustees Of The University Of Pennsylvania | Methods of increasing response to cancer radiation therapy |
| EP4137519A1 (en) * | 2013-08-09 | 2023-02-22 | The Trustees Of The University Of Pennsylvania | Fusion protein comprising ifn-gamma and anti-erbb antibody for the treatment of cancers |
| CN104193828B (zh) * | 2013-09-12 | 2017-04-05 | 北京韩美药品有限公司 | 同时阻断her2和vegfr信号通路的重组融合蛋白 |
| CN105829349B (zh) * | 2013-10-15 | 2023-02-03 | 斯克利普斯研究所 | 肽嵌合抗原受体t细胞开关和其用途 |
| CN103536917B (zh) * | 2013-10-30 | 2015-03-11 | 苏州丁孚靶点生物技术有限公司 | 干扰素在治疗肿瘤中的用途及相关的产品和方法 |
| KR20240134226A (ko) | 2013-12-04 | 2024-09-06 | 추가이 세이야쿠 가부시키가이샤 | 화합물의 농도에 따라 항원 결합능이 변화되는 항원 결합 분자 및 그의 라이브러리 |
| WO2015168474A1 (en) | 2014-04-30 | 2015-11-05 | President And Fellows Of Harvard College | Fusion proteins for treating cancer and related methods |
| UA119352C2 (uk) | 2014-05-01 | 2019-06-10 | Тева Фармасьютикалз Острейліа Пті Лтд | Комбінація леналідоміду або помалідоміду і конструкції анти-cd38 антитіло-атенуйований інтерферон альфа-2b та спосіб лікування суб'єкта, який має cd38-експресуючу пухлину |
| IL251822B2 (en) | 2014-10-29 | 2023-03-01 | Teva Pharmaceuticals Australia Pty Ltd | Variants of interferon alpha-2-b |
| EP3221351B1 (en) * | 2014-11-19 | 2024-11-13 | Memorial Sloan-Kettering Cancer Center | Methods and compositions for cancer treating conditions relating to over expressions of epha2 |
| CN104403004B (zh) * | 2014-11-24 | 2017-10-13 | 苏州丁孚靶点生物技术有限公司 | 抗体‑干扰素异二聚体的制备和用途 |
| US20170002057A1 (en) * | 2015-02-26 | 2017-01-05 | Nal Pharmaceutical Group Limited | Compositions containing fusion protein of albumin and analogs thereof, methods for making and using the same |
| US20210009720A1 (en) * | 2015-03-03 | 2021-01-14 | Genopharm Inc. | Human interferon-beta variant conjugated immunocytokine and method for preparing same |
| KR101838919B1 (ko) * | 2015-03-03 | 2018-03-15 | 에이비온 주식회사 | 인간 인터페론-베타 변이체가 접합된 면역사이토카인 및 이의 제조방법 |
| WO2016154621A1 (en) | 2015-03-26 | 2016-09-29 | The California Institute For Biomedical Research | SWITCHABLE NON-scFv CHIMERIC RECEPTORS, SWITCHES, AND USES THEREOF |
| US11091546B2 (en) | 2015-04-15 | 2021-08-17 | The Scripps Research Institute | Optimized PNE-based chimeric receptor T cell switches and uses thereof |
| EP3307301A4 (en) * | 2015-06-12 | 2019-04-10 | ImmunGene, Inc. | FOCUSED INTERFERON IMMUNOTHERAPY FOR THE TREATMENT OF CANCER |
| MX394116B (es) | 2015-07-24 | 2025-03-19 | Gliknik Inc | Proteinas de fusion de fragmentos de proteina humana para crear composiciones de fc de inmunoglobulina multimerizada de forma ordenada con union al complemento aumentada. |
| JP6452577B2 (ja) * | 2015-08-27 | 2019-01-16 | 株式会社沖データ | 画像形成装置 |
| WO2017077382A1 (en) | 2015-11-06 | 2017-05-11 | Orionis Biosciences Nv | Bi-functional chimeric proteins and uses thereof |
| WO2017123548A1 (en) * | 2016-01-14 | 2017-07-20 | Seattle Children's Hospital (dba Seattle Children's Research Institute) | Tumor-specific ifna secretion by car t-cells to reprogram the solid tumor microenvironment |
| CN115850521A (zh) | 2016-02-05 | 2023-03-28 | 奥里尼斯生物科学私人有限公司 | 靶向性治疗剂及其用途 |
| US11661455B2 (en) | 2016-02-05 | 2023-05-30 | Orionis Biosciences BV | Chimeric protein comprising an interferon alpha 2mutant and a PD-L1 binding moiety |
| WO2017153402A1 (en) | 2016-03-07 | 2017-09-14 | Vib Vzw | Cd20 binding single domain antibodies |
| WO2017180764A1 (en) * | 2016-04-12 | 2017-10-19 | Immungene, Inc. | Focused interferon immunotherapy |
| CN109563141A (zh) | 2016-05-13 | 2019-04-02 | 奥里尼斯生物科学公司 | 对非细胞结构的治疗性靶向 |
| WO2017194783A1 (en) | 2016-05-13 | 2017-11-16 | Orionis Biosciences Nv | Targeted mutant interferon-beta and uses thereof |
| AU2017279538A1 (en) | 2016-06-07 | 2019-01-03 | Gliknik Inc. | Cysteine-optimized stradomers |
| WO2018014067A1 (en) | 2016-07-19 | 2018-01-25 | Teva Pharmaceuticals Australia Pty Ltd | Anti-cd47 combination therapy |
| AU2017345479B2 (en) | 2016-10-19 | 2024-03-21 | The Scripps Research Institute | Chimeric antigen receptor effector cell switches with humanized targeting moieties and/or optimized chimeric antigen receptor interacting domains and uses thereof |
| CA3040802A1 (en) | 2016-10-24 | 2018-05-03 | Orionis Biosciences Nv | Targeted mutant interferon-gamma and uses thereof |
| IL317014A (en) | 2016-12-09 | 2025-01-01 | Gliknik Inc | Production optimization of GL-2045, a multimerization sterol. |
| CN110022898B (zh) | 2016-12-09 | 2023-07-04 | 格利克尼克股份有限公司 | 用多价Fc化合物治疗炎性疾病的方法 |
| WO2018119475A1 (en) * | 2016-12-23 | 2018-06-28 | Remd Biotherapeutics, Inc. | Immunotherapy using antibodies that bind programmed death ligand-1 (pd-l1) |
| MX2019009255A (es) | 2017-02-06 | 2019-11-05 | Orionis Biosciences Nv | Proteínas quiméricas dirigidas y sus usos. |
| CN110573172A (zh) | 2017-02-06 | 2019-12-13 | 奥里尼斯生物科学有限公司 | 靶向的工程化干扰素及其用途 |
| CA3050601A1 (en) | 2017-02-07 | 2018-08-16 | Vib Vzm | Immune-cell targeted bispecific chimeric proteins and uses thereof |
| AU2018313810B2 (en) | 2017-08-09 | 2025-05-15 | Orionis Biosciences BV | Clec9A binding agents and use thereof |
| CA3069930A1 (en) | 2017-08-09 | 2019-02-14 | Orionis Biosciences Inc. | Cd8 binding agents |
| CN111328286B (zh) | 2017-08-09 | 2024-08-23 | 奥里尼斯生物科学有限公司 | Pd-1和pd-l1结合剂 |
| WO2019051204A1 (en) | 2017-09-08 | 2019-03-14 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | SYNERGISTIC COMBINATION OF IL4, INTERFERON GAMMA AND INTERFERON ALPHA RECEPTOR AGENTS FOR USE IN THE TREATMENT OF OVARIAN CANCER |
| US12415843B2 (en) * | 2018-03-19 | 2025-09-16 | The Regents Of The University Of California | Antibody-interferon fusion proteins for enhancing adoptive T cell therapies for the treatment of cancer |
| CA3108795A1 (en) | 2018-08-08 | 2020-02-13 | Orionis Biosciences, Inc. | Sirp1a targeted chimeric proteins and uses thereof |
| SG10202106830VA (en) | 2018-08-10 | 2021-08-30 | Chugai Pharmaceutical Co Ltd | Anti-cd137 antigen-binding molecule and utilization thereof |
| CA3118892A1 (en) | 2018-11-08 | 2020-05-14 | Orionis Biosciences, Inc. | Modulation of dendritic cell lineages |
| CN114072164A (zh) * | 2019-03-06 | 2022-02-18 | 德卡生物科学公司 | Il-10变体分子和治疗炎性疾病和肿瘤的方法 |
| US12351614B2 (en) | 2019-03-28 | 2025-07-08 | Orionis Biosciences, Inc. | CLEC9A-based chimeric protein complexes |
| CA3133643A1 (en) * | 2019-03-28 | 2020-10-01 | Orionis Biosciences, Inc. | Therapeutic interferon alpha 1 proteins |
| JP2022529943A (ja) | 2019-04-15 | 2022-06-27 | クウィクセル セラピューティクス リミテッド ライアビリティ カンパニー | がんの処置における使用のための、標的指向性のマスクされたi型インターフェロン(ifnaおよびifnb)と腫瘍抗原に対する抗体とを含む融合タンパク質組成物 |
| KR20210021861A (ko) * | 2019-08-19 | 2021-03-02 | (주)제노팜 | 사람 표피성장인자수용체 2 양성 암을 치료하기 위한 인터페론-베타 변이체 면역사이토카인의 용도 및 환자 선별 방법 |
| MX2022005666A (es) * | 2019-11-14 | 2022-10-07 | Werewolf Therapeutics Inc | Polipeptidos de citocina activables y metodos de uso de los mismos. |
| CN115052625B (zh) | 2019-12-03 | 2024-11-01 | 埃沃特克国际有限责任公司 | 干扰素相关抗原结合蛋白及其用途 |
| US20230310581A1 (en) * | 2020-04-27 | 2023-10-05 | Ohio State Innovation Foundation | A live attenuated measles virus vectored vaccine for sars-cov-2 |
| EP4181957A4 (en) | 2020-07-20 | 2024-08-07 | Deka Biosciences, Inc. | TWO-CYTOKINE FUSION PROTEIN COMPRISING IL-10 |
| EP4386007A1 (en) * | 2021-08-12 | 2024-06-19 | Shanghai TTM-BIO Technology Co., Ltd. | Bispecific recombinant protein and use thereof |
| KR20240015037A (ko) * | 2022-07-25 | 2024-02-02 | 충남대학교산학협력단 | Vc1 분비를 위한 재조합 발현 벡터 및 이로 형질전환된약독화 살모넬라 균주 |
| CN120051483A (zh) | 2022-08-18 | 2025-05-27 | 再生元制药公司 | 干扰素前蛋白及其用途 |
| US20240067691A1 (en) | 2022-08-18 | 2024-02-29 | Regeneron Pharmaceuticals, Inc. | Interferon receptor agonists and uses thereof |
| WO2024238415A1 (en) | 2023-05-12 | 2024-11-21 | Regeneron Pharmaceuticals, Inc. | Interferon receptor antagonists and uses thereof |
| WO2025106883A1 (en) * | 2023-11-15 | 2025-05-22 | President And Fellows Of Harvard College | Engineered fc-prolactin fusions to increase lactation |
Family Cites Families (70)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4458066A (en) | 1980-02-29 | 1984-07-03 | University Patents, Inc. | Process for preparing polynucleotides |
| FR2504010B1 (fr) | 1981-04-15 | 1985-10-25 | Sanofi Sa | Medicaments anticancereux contenant la chaine a de la ricine associee a un anticorps antimelanome et procede pour leur preparation |
| US4474893A (en) | 1981-07-01 | 1984-10-02 | The University of Texas System Cancer Center | Recombinant monoclonal antibodies |
| US4671958A (en) | 1982-03-09 | 1987-06-09 | Cytogen Corporation | Antibody conjugates for the delivery of compounds to target sites |
| EP0092227B1 (en) | 1982-04-19 | 1988-07-27 | Nissan Motor Co., Ltd. | Method for controlling reduction ratio of continuously variable transmission with acceleration compensation |
| US4545985A (en) | 1984-01-26 | 1985-10-08 | The United States Of America As Represented By The Secretary, Dept. Of Health And Human Services | Pseudomonas exotoxin conjugate immunotoxins |
| US4894443A (en) | 1984-02-08 | 1990-01-16 | Cetus Corporation | Toxin conjugates |
| US4542225A (en) | 1984-08-29 | 1985-09-17 | Dana-Farber Cancer Institute, Inc. | Acid-cleavable compound |
| US4659839A (en) | 1984-10-10 | 1987-04-21 | Mallinckrodt, Inc. | Coupling agents for radiolabeled antibody fragments |
| EP0188256B1 (en) | 1985-01-14 | 1991-08-21 | NeoRx | Metal radionuclide labeled proteins for diagnosis and therapy |
| US4680338A (en) | 1985-10-17 | 1987-07-14 | Immunomedics, Inc. | Bifunctional linker |
| US4699784A (en) | 1986-02-25 | 1987-10-13 | Center For Molecular Medicine & Immunology | Tumoricidal methotrexate-antibody conjugate |
| US4892827A (en) * | 1986-09-24 | 1990-01-09 | The United States Of America As Represented By The Department Of Health And Human Services | Recombinant pseudomonas exotoxins: construction of an active immunotoxin with low side effects |
| US6893625B1 (en) * | 1986-10-27 | 2005-05-17 | Royalty Pharma Finance Trust | Chimeric antibody with specificity to human B cell surface antigen |
| US5091513A (en) | 1987-05-21 | 1992-02-25 | Creative Biomolecules, Inc. | Biosynthetic antibody binding sites |
| US5132405A (en) | 1987-05-21 | 1992-07-21 | Creative Biomolecules, Inc. | Biosynthetic antibody binding sites |
| JPS6412935A (en) | 1987-07-02 | 1989-01-17 | Mitsubishi Electric Corp | Constant-speed travel device for vehicle |
| WO1989006692A1 (en) | 1988-01-12 | 1989-07-27 | Genentech, Inc. | Method of treating tumor cells by inhibiting growth factor receptor function |
| US5976531A (en) | 1990-04-19 | 1999-11-02 | The Dow Chemical Company | Composite antibodies of human subgroup IV light chain capable of binding to tag-72 |
| ATE247168T1 (de) | 1991-03-06 | 2003-08-15 | Merck Patent Gmbh | Humanisierte monoklonale antikörper |
| SE9400088D0 (sv) | 1994-01-14 | 1994-01-14 | Kabi Pharmacia Ab | Bacterial receptor structures |
| CZ292061B6 (cs) | 1994-03-17 | 2003-07-16 | Merck Patent Gmbh | Jednořetězcové fragmenty protilátek a protilátky proti receptoru epidermálního růstového faktoru, způsob jejich přípravy a farmaceutický prostředek, který je obsahuje |
| PT706799E (pt) | 1994-09-16 | 2002-05-31 | Merck Patent Gmbh | Imunoconjugados ii |
| US6428788B1 (en) * | 1995-03-15 | 2002-08-06 | Penn State University | Compositions and methods for specifically targeting tumors |
| EP0873363B1 (en) * | 1995-06-14 | 2010-10-06 | The Regents of The University of California | High affinity human antibodies to tumor antigens |
| JPH11513669A (ja) * | 1995-10-13 | 1999-11-24 | アメリカ合衆国 | ジスルフィド安定化抗体フラグメントを含む免疫毒素 |
| US5723125A (en) | 1995-12-28 | 1998-03-03 | Tanox Biosystems, Inc. | Hybrid with interferon-alpha and an immunoglobulin Fc linked through a non-immunogenic peptide |
| US6193972B1 (en) * | 1996-02-20 | 2001-02-27 | Applied Research Systems Ars Holding N.V. | Hybrid heterodimeric protein hormone |
| US6645490B2 (en) * | 1998-03-02 | 2003-11-11 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Chimeric proteins with cell-targeting specificity and apoptosis-inducing activities |
| US6365408B1 (en) | 1998-06-19 | 2002-04-02 | Maxygen, Inc. | Methods of evolving a polynucleotides by mutagenesis and recombination |
| EE200100203A (et) * | 1998-10-05 | 2002-10-15 | M & E Biotech A/S | Meetod immuunvastuse indutseerimiseks polüpeptiidse antigeeni vastu ja rakuga seotud polüpeptiidse antigeeni mahasurumiseks loomorganismil, selle meetodi kasutamine eesnäärme- ja rinnavähi raviks ning immunogeenne kompositsioon |
| MXPA01003790A (es) * | 1998-10-16 | 2002-09-18 | Biogen Inc | Proteinas de fusion beta - interferon y sus usos. |
| JP4944324B2 (ja) * | 1999-07-13 | 2012-05-30 | ボルダー バイオテクノロジー, インコーポレイテッド | 免疫グロブリン融合タンパク質 |
| AU2001266557A1 (en) * | 2000-04-12 | 2001-10-23 | Human Genome Sciences, Inc. | Albumin fusion proteins |
| AU2001265418B2 (en) * | 2000-06-22 | 2006-03-30 | Biogen Idec Inc. | Bispecific fusion protein and method of use for enhancing effector cell killing of target cells |
| WO2002046227A2 (en) * | 2000-12-07 | 2002-06-13 | Eli Lilly And Company | Glp-1 fusion proteins |
| US7183388B2 (en) * | 2001-03-30 | 2007-02-27 | The Regents Of The University Of California | Anti-MUC-1 single chain antibodies for tumor targeting |
| US20020193569A1 (en) * | 2001-06-04 | 2002-12-19 | Idec Pharmaceuticals Corporation | Bispecific fusion protein and method of use for enhancing effector cell killing of target cells |
| CN100522999C (zh) | 2002-02-14 | 2009-08-05 | 免疫医疗公司 | 抗cd20抗体及其融合蛋白和使用方法 |
| US7736652B2 (en) * | 2002-03-21 | 2010-06-15 | The Regents Of The University Of California | Antibody fusion proteins: effective adjuvants of protein vaccination |
| US7332585B2 (en) | 2002-04-05 | 2008-02-19 | The Regents Of The California University | Bispecific single chain Fv antibody molecules and methods of use thereof |
| US7332580B2 (en) | 2002-04-05 | 2008-02-19 | The Regents Of The University Of California | Bispecific single chain Fv antibody molecules and methods of use thereof |
| US20070003514A1 (en) | 2002-04-05 | 2007-01-04 | The Regents Of The University Of California | Mono-and bi-functional antibody conjugates as effective adjuvants of protein vaccination |
| JP2004093527A (ja) * | 2002-09-04 | 2004-03-25 | Center For Advanced Science & Technology Incubation Ltd | 蛍光共鳴エネルギー転移を用いた蛋白質の分析方法 |
| PL376673A1 (pl) | 2003-02-18 | 2006-01-09 | Merck Patent Gmbh | Białka fuzyjne mutein interferonu alfa o ulepszonych właściwościach |
| WO2005021710A2 (en) * | 2003-06-02 | 2005-03-10 | University Of Miami | Chimeric molecules and methods of use |
| US20050232931A1 (en) * | 2003-06-13 | 2005-10-20 | Oncomax Acquisition Corp. | Preparation and application of anti-tumor bifunctional fusion proteins |
| US7670595B2 (en) * | 2004-06-28 | 2010-03-02 | Merck Patent Gmbh | Fc-interferon-beta fusion proteins |
| EP2940043A1 (en) | 2004-07-15 | 2015-11-04 | Xencor, Inc. | Optimized fc variants |
| AU2005266184A1 (en) * | 2004-07-26 | 2006-02-02 | Asterion Limited | Linkers |
| JP2008526889A (ja) * | 2005-01-10 | 2008-07-24 | リサーチ ディベロップメント ファウンデーション | 癌治療のための標的化キメラ分子 |
| US20120237442A1 (en) | 2005-04-06 | 2012-09-20 | Ibc Pharmaceuticals, Inc. | Design and Construction of Novel Multivalent Antibodies |
| CN101484182B (zh) * | 2005-04-06 | 2014-06-11 | Ibc药品公司 | 由同二聚体、同四聚体或二聚体的二聚体组成的稳定连接复合体的生产方法及用途 |
| US20060269516A1 (en) * | 2005-05-26 | 2006-11-30 | Schering Corporation | Interferon-IgG fusion |
| EP1909822B1 (en) * | 2005-06-29 | 2013-09-25 | Yeda Research And Development Co., Ltd. | Recombinant interferon alpha 2 (ifn alpha 2) mutants |
| NZ542111A (en) | 2005-08-30 | 2008-04-30 | Otago Innovation Ltd | Novel assay |
| JP4860703B2 (ja) | 2005-10-06 | 2012-01-25 | ゼンコー・インコーポレイテッド | 最適化された抗cd30抗体 |
| KR101866623B1 (ko) | 2005-11-28 | 2018-07-04 | 젠맵 에이/에스 | 재조합 1가 항체 및 그의 제조 방법 |
| MX2010003099A (es) * | 2007-09-21 | 2010-05-17 | Univ California | Interferon de objetivo demuestra actividades potentes apoptoticas y antitumorales. |
| US20100047164A1 (en) | 2008-04-11 | 2010-02-25 | Duke University | Anti-Tumor Antibodies |
| WO2009134870A1 (en) | 2008-04-30 | 2009-11-05 | Immunogen, Inc. | Potent cell-binding agent drug conjugates |
| AU2009293007B2 (en) | 2008-09-19 | 2015-10-08 | University Of Pittsburgh-Of The Commonwealth System Of Higher Education | Monoclonal antibodies for cspg4 for the diagnosis and treatment of basal breast carcinoma |
| CA2761120A1 (en) | 2009-05-06 | 2010-11-11 | Biotest Ag | Uses of immunoconjugates targeting cd138 |
| US20110165122A1 (en) * | 2009-11-10 | 2011-07-07 | The Regents Of The University Of California | Method for targeted and sustained antiviral therapy |
| WO2012075324A1 (en) | 2010-12-02 | 2012-06-07 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Methods for treating a tumor using an antibody that specifically binds hmw-maa |
| MX2013009151A (es) | 2011-02-10 | 2013-08-29 | Roche Glycart Ag | Inmunoterapia mejorada. |
| WO2013050725A1 (en) | 2011-10-04 | 2013-04-11 | King's College London | Ige anti -hmw-maa antibody |
| EP3799880A3 (en) * | 2012-03-03 | 2021-06-23 | ImmunGene, Inc. | Engineered antibody-interferon mutant fusion molecules |
| WO2014089354A1 (en) | 2012-12-07 | 2014-06-12 | The Regents Of The University Of California | Cd138-targeted interferon demonstrates potent apoptotic and anti-tumor activities |
| US10093745B2 (en) | 2013-05-29 | 2018-10-09 | The Regents Of The University Of California | Anti-CSPG4 fusions with interferon for the treatment of malignancy |
-
2008
- 2008-09-19 MX MX2010003099A patent/MX2010003099A/es active IP Right Grant
- 2008-09-19 MX MX2014010567A patent/MX349306B/es unknown
- 2008-09-19 WO PCT/US2008/077074 patent/WO2009039409A1/en not_active Ceased
- 2008-09-19 KR KR1020107008737A patent/KR101661770B1/ko active Active
- 2008-09-19 CN CN201410160383.9A patent/CN103880965B/zh active Active
- 2008-09-19 ES ES08831632.8T patent/ES2536772T3/es active Active
- 2008-09-19 EP EP20080831632 patent/EP2200634B1/en active Active
- 2008-09-19 US US12/678,981 patent/US9139634B2/en active Active
- 2008-09-19 BR BRPI0817108A patent/BRPI0817108B8/pt active IP Right Grant
- 2008-09-19 KR KR1020167014105A patent/KR101759460B1/ko active Active
- 2008-09-19 CA CA2699944A patent/CA2699944C/en active Active
- 2008-09-19 JP JP2010526011A patent/JP5591701B2/ja active Active
- 2008-09-19 EP EP16195608.1A patent/EP3150218B1/en active Active
- 2008-09-19 CN CN200880117225A patent/CN101868246A/zh active Pending
- 2008-09-19 EP EP14180412.0A patent/EP2853267B1/en active Active
- 2008-09-19 AU AU2008302111A patent/AU2008302111B2/en active Active
- 2008-09-19 CN CN201810058393.XA patent/CN108129573B/zh active Active
-
2009
- 2009-12-30 US US12/650,329 patent/US8258263B2/en active Active
-
2010
- 2010-03-21 IL IL20464410A patent/IL204644A/en active IP Right Grant
-
2011
- 2011-01-05 US US12/985,122 patent/US8563692B2/en not_active Expired - Fee Related
-
2013
- 2013-08-30 US US14/015,838 patent/US9534033B2/en active Active
-
2014
- 2014-06-22 IL IL233305A patent/IL233305B/en active IP Right Grant
- 2014-07-30 JP JP2014154820A patent/JP6087871B2/ja not_active Expired - Fee Related
-
2016
- 2016-11-02 JP JP2016215048A patent/JP2017031215A/ja active Pending
- 2016-11-22 US US15/359,456 patent/US10182984B2/en active Active
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2010540453A5 (OSRAM) | ||
| JP2010516290A5 (OSRAM) | ||
| JP2012100677A5 (OSRAM) | ||
| JP2010516708A5 (OSRAM) | ||
| CN105142663A (zh) | 用于癌症靶向治疗的含有结合白蛋白的精氨酸脱亚胺酶的药物组合物 | |
| JP2009507470A5 (OSRAM) | ||
| CN110981958B (zh) | 一种pd-l1抗体 | |
| JP2013513377A5 (OSRAM) | ||
| JP2009540852A5 (OSRAM) | ||
| JP2010509931A5 (OSRAM) | ||
| CN110300766A (zh) | 新型重组双功能融合蛋白及其制备方法和用途 | |
| CN105111314A (zh) | 一种新型融合蛋白、药物组合物及其制备方法和用途 | |
| CN103582494A (zh) | 靶向e-钙粘着蛋白的可溶性细胞外结构域的组合物和用于癌症治疗的有关方法 | |
| CN111278847A (zh) | 分子导向系统肽及其用途 | |
| JP2021517472A (ja) | 抗pd−l1ワクチン組成物 | |
| JP2015512247A5 (OSRAM) | ||
| CN111218443B (zh) | 合成核酸药物偶联物的方法 | |
| CN115916839A (zh) | 抗pdl1×egfr的双特异性抗体 | |
| JP2006345867A5 (OSRAM) | ||
| CN115028738B (zh) | 一种Fc融合蛋白双重靶向降解剂及应用 | |
| CN108341854A (zh) | 一种肿瘤靶向的新型多肽及其用途 | |
| CN101143902B (zh) | 抗HER2单链抗体-力达霉素强化融合蛋白HER2(Fv-LDM) | |
| WO2023020537A1 (zh) | 一种双特异性抗体及其用途 | |
| CN117964760B (zh) | 抗人cll1/cd3的双特异性抗体及其应用 | |
| JP2015533372A5 (OSRAM) |