JP2010538062A5 - - Google Patents
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- Publication number
- JP2010538062A5 JP2010538062A5 JP2010523991A JP2010523991A JP2010538062A5 JP 2010538062 A5 JP2010538062 A5 JP 2010538062A5 JP 2010523991 A JP2010523991 A JP 2010523991A JP 2010523991 A JP2010523991 A JP 2010523991A JP 2010538062 A5 JP2010538062 A5 JP 2010538062A5
- Authority
- JP
- Japan
- Prior art keywords
- formulation
- azithromycin
- release solid
- sustained
- less
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Revoked
Links
- 238000009472 formulation Methods 0.000 claims description 43
- 239000000203 mixture Substances 0.000 claims description 43
- MQTOSJVFKKJCRP-BICOPXKESA-N azithromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)N(C)C[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 MQTOSJVFKKJCRP-BICOPXKESA-N 0.000 claims description 42
- 229960004099 azithromycin Drugs 0.000 claims description 42
- 230000009246 food effect Effects 0.000 claims description 12
- 235000021471 food effect Nutrition 0.000 claims description 12
- 239000002775 capsule Substances 0.000 claims description 11
- 239000007787 solid Substances 0.000 claims 57
- 239000012730 sustained-release form Substances 0.000 claims 54
- 238000013268 sustained release Methods 0.000 claims 53
- 238000002360 preparation method Methods 0.000 claims 40
- 238000000034 method Methods 0.000 claims 27
- 235000020925 non fasting Nutrition 0.000 claims 8
- 208000002874 Acne Vulgaris Diseases 0.000 claims 7
- 206010000496 acne Diseases 0.000 claims 7
- 239000002702 enteric coating Substances 0.000 claims 7
- 238000009505 enteric coating Methods 0.000 claims 7
- 239000002245 particle Substances 0.000 claims 7
- 239000012729 immediate-release (IR) formulation Substances 0.000 claims 4
- 229920002785 Croscarmellose sodium Polymers 0.000 claims 3
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 claims 3
- 239000011230 binding agent Substances 0.000 claims 3
- FUFJGUQYACFECW-UHFFFAOYSA-L calcium hydrogenphosphate Chemical compound [Ca+2].OP([O-])([O-])=O FUFJGUQYACFECW-UHFFFAOYSA-L 0.000 claims 3
- 229960001681 croscarmellose sodium Drugs 0.000 claims 3
- 235000010947 crosslinked sodium carboxy methyl cellulose Nutrition 0.000 claims 3
- 235000019700 dicalcium phosphate Nutrition 0.000 claims 3
- 229940095079 dicalcium phosphate anhydrous Drugs 0.000 claims 3
- 239000007884 disintegrant Substances 0.000 claims 3
- 239000000945 filler Substances 0.000 claims 3
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims 3
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims 3
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims 3
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims 3
- 229920001223 polyethylene glycol Polymers 0.000 claims 3
- 239000002202 Polyethylene glycol Substances 0.000 claims 2
- 230000003111 delayed effect Effects 0.000 claims 2
- 229920003145 methacrylic acid copolymer Polymers 0.000 claims 2
- 229940117841 methacrylic acid copolymer Drugs 0.000 claims 2
- 229910000831 Steel Inorganic materials 0.000 claims 1
- 229940085314 azithromycin 250 mg Drugs 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 239000006186 oral dosage form Substances 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 239000007909 solid dosage form Substances 0.000 claims 1
- 239000012439 solid excipient Substances 0.000 claims 1
- 239000010959 steel Substances 0.000 claims 1
- 238000006677 Appel reaction Methods 0.000 description 1
- 229960000074 biopharmaceutical Drugs 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 230000002496 gastric effect Effects 0.000 description 1
- 239000002547 new drug Substances 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US96750407P | 2007-09-05 | 2007-09-05 | |
| US12/002,417 US8124123B2 (en) | 2007-09-05 | 2007-12-17 | Controlled release azithromycin solid dosages forms |
| PCT/US2008/009169 WO2009032037A1 (en) | 2007-09-05 | 2008-07-30 | Controlled release azithromycin solid dosages forms |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2010538062A JP2010538062A (ja) | 2010-12-09 |
| JP2010538062A5 true JP2010538062A5 (https=) | 2011-09-15 |
Family
ID=40407900
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010523991A Revoked JP2010538062A (ja) | 2007-09-05 | 2008-07-30 | 徐放性アジスロマイシン固形製剤 |
| JP2010524023A Withdrawn JP2010538066A (ja) | 2007-09-05 | 2008-09-04 | 皮膚疾患治療用アジスロマイシン |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010524023A Withdrawn JP2010538066A (ja) | 2007-09-05 | 2008-09-04 | 皮膚疾患治療用アジスロマイシン |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US8124123B2 (https=) |
| EP (2) | EP2197420A4 (https=) |
| JP (2) | JP2010538062A (https=) |
| KR (2) | KR20100063088A (https=) |
| CN (2) | CN101861138A (https=) |
| AR (1) | AR068368A1 (https=) |
| AU (2) | AU2008295579A1 (https=) |
| BR (1) | BRPI0816268A2 (https=) |
| CA (2) | CA2697496A1 (https=) |
| RU (2) | RU2010109358A (https=) |
| WO (2) | WO2009032037A1 (https=) |
| ZA (2) | ZA201001649B (https=) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE482695T1 (de) | 2002-12-13 | 2010-10-15 | Durect Corp | Orale darreichungsform mit flüssigen hochviskosen trägersystemen |
| JP2011506319A (ja) | 2007-12-06 | 2011-03-03 | デュレクト コーポレーション | 疼痛、関節炎症状、または慢性疾患に伴う炎症の治療に有用な方法 |
| US20100260844A1 (en) | 2008-11-03 | 2010-10-14 | Scicinski Jan J | Oral pharmaceutical dosage forms |
| AU2014233453A1 (en) | 2013-03-15 | 2015-10-01 | Durect Corporation | Compositions with a rheological modifier to reduce dissolution variability |
| US12274794B2 (en) | 2016-07-06 | 2025-04-15 | Orient Pharma Co., Ltd. | Oral dosage form with drug composition, barrier layer and drug layer |
| JP7262118B2 (ja) * | 2016-10-06 | 2023-04-21 | オーバス セラピューティクス インコーポレイテッド | 医薬組成物およびその使用 |
| CN109875970B (zh) * | 2019-01-08 | 2021-08-06 | 石家庄四药有限公司 | 阿奇霉素固体制剂及其制备方法 |
| CN113116859B (zh) * | 2021-04-12 | 2022-08-30 | 海南普利制药股份有限公司 | 阿奇霉素丸芯包衣制剂 |
| WO2023283427A2 (en) * | 2021-07-09 | 2023-01-12 | Verdure Biotech, Inc. | Enteric and delayed release formulations of locally bioavailable drugs (lbd) targeting the colon |
| US12605349B2 (en) | 2024-09-05 | 2026-04-21 | Orbus Therapeutics, Inc. | Methods of treating grade 3 astrocytoma |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4474768A (en) * | 1982-07-19 | 1984-10-02 | Pfizer Inc. | N-Methyl 11-aza-10-deoxo-10-dihydro-erytromycin A, intermediates therefor |
| US5605889A (en) * | 1994-04-29 | 1997-02-25 | Pfizer Inc. | Method of administering azithromycin |
| EP0758244B2 (en) * | 1994-05-06 | 2008-02-13 | Pfizer Inc. | Controlled-release dosage forms of azithromycin |
| US5543417A (en) * | 1994-10-21 | 1996-08-06 | Merck & Co., Inc. | Combination method of treating acne using 4-AZA-5α-cholestan-ones and 4-AZA-5α-androstan-ones as selective 5α-reductase inhibitors with anti-bacterial, keratolytic, or anti-inflammatory agents |
| EP0951278A2 (en) * | 1997-01-03 | 1999-10-27 | ELAN CORPORATION, Plc | Sustained release cisapride mini-tablet formulation |
| US6368628B1 (en) * | 2000-05-26 | 2002-04-09 | Pharma Pass Llc | Sustained release pharmaceutical composition free of food effect |
| US7670627B2 (en) * | 2002-12-09 | 2010-03-02 | Salvona Ip Llc | pH triggered targeted controlled release systems for the delivery of pharmaceutical active ingredients |
| DE602004028023D1 (de) * | 2003-08-29 | 2010-08-19 | Lifecycle Pharma As | Tacrolimus enthaltende feste dispersionen |
| US20050239723A1 (en) * | 2004-04-27 | 2005-10-27 | Amin Avinash N | Compositions and methods useful for treatment of acne |
| CA2591923A1 (en) | 2004-12-21 | 2006-06-29 | Pfizer Products Inc. | Enteric coated azithromycin multiparticulates |
| US20060280789A1 (en) * | 2004-12-27 | 2006-12-14 | Eisai Research Institute | Sustained release formulations |
| CN101217944A (zh) * | 2005-04-08 | 2008-07-09 | 艾博特公司 | 包含非诺贝酸和/或其盐的口服药物制剂 |
| BRPI0617693A2 (pt) * | 2005-11-09 | 2011-08-02 | Dow Pharmaceutical Sciences | azitromicina para o tratamento de rosácea granulomatosa |
| US7704959B2 (en) * | 2006-10-03 | 2010-04-27 | Dow Pharmaceutical Sciences | Azithromycin for the treatment of nodular acne |
-
2007
- 2007-12-17 US US12/002,417 patent/US8124123B2/en not_active Expired - Fee Related
-
2008
- 2008-07-30 JP JP2010523991A patent/JP2010538062A/ja not_active Revoked
- 2008-07-30 KR KR1020107006490A patent/KR20100063088A/ko not_active Withdrawn
- 2008-07-30 BR BRPI0816268A patent/BRPI0816268A2/pt not_active IP Right Cessation
- 2008-07-30 CN CN200880105792A patent/CN101861138A/zh active Pending
- 2008-07-30 WO PCT/US2008/009169 patent/WO2009032037A1/en not_active Ceased
- 2008-07-30 AU AU2008295579A patent/AU2008295579A1/en not_active Abandoned
- 2008-07-30 EP EP08780336A patent/EP2197420A4/en not_active Withdrawn
- 2008-07-30 CA CA2697496A patent/CA2697496A1/en not_active Abandoned
- 2008-07-30 RU RU2010109358/15A patent/RU2010109358A/ru unknown
- 2008-09-04 RU RU2010109359/15A patent/RU2010109359A/ru not_active Application Discontinuation
- 2008-09-04 KR KR1020107006491A patent/KR20100054842A/ko not_active Withdrawn
- 2008-09-04 CN CN200880105803A patent/CN101835475A/zh active Pending
- 2008-09-04 AU AU2008296903A patent/AU2008296903A1/en not_active Abandoned
- 2008-09-04 JP JP2010524023A patent/JP2010538066A/ja not_active Withdrawn
- 2008-09-04 WO PCT/US2008/010355 patent/WO2009032268A1/en not_active Ceased
- 2008-09-04 CA CA2697537A patent/CA2697537A1/en not_active Abandoned
- 2008-09-04 AR ARP080103847A patent/AR068368A1/es not_active Application Discontinuation
- 2008-09-04 EP EP08829925A patent/EP2197453A4/en not_active Withdrawn
-
2010
- 2010-03-08 ZA ZA2010/01649A patent/ZA201001649B/en unknown
- 2010-03-10 ZA ZA2010/01705A patent/ZA201001705B/en unknown
-
2012
- 2012-01-25 US US13/357,722 patent/US20120121702A1/en not_active Abandoned
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