JP2010535277A - 調節可能架橋ヒアルロン酸組成物 - Google Patents
調節可能架橋ヒアルロン酸組成物 Download PDFInfo
- Publication number
- JP2010535277A JP2010535277A JP2010520076A JP2010520076A JP2010535277A JP 2010535277 A JP2010535277 A JP 2010535277A JP 2010520076 A JP2010520076 A JP 2010520076A JP 2010520076 A JP2010520076 A JP 2010520076A JP 2010535277 A JP2010535277 A JP 2010535277A
- Authority
- JP
- Japan
- Prior art keywords
- hyaluronic acid
- crosslinking agent
- polyethylene glycol
- multifunctional
- composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Images
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
- C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
- C08B37/0072—Hyaluronic acid, i.e. HA or hyaluronan; Derivatives thereof, e.g. crosslinked hyaluronic acid (hylan) or hyaluronates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/20—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/34—Materials or treatment for tissue regeneration for soft tissue reconstruction
Abstract
Description
1gのヒアルロン酸ナトリウムファイバー(NaHA、Mw=0.5〜3MDa)を、5〜10gの0.01〜1%水酸化ナトリウム溶液と混合し、混合物を1〜5時間水和させる。次に、20〜200mgの1,4-ブタンジオールジグリシジルエーテル(BDDE)および0.05〜2gの4-Arm Star PEGエポキシド(Mw=200〜10,000Da)を、NaHAゲルに添加する。混合物を機械的に均質化し、次に、40〜70℃のオーブンに1〜10時間入れる。得られた架橋ヒドロゲルを、等モル量の塩酸で中和し、リン酸塩緩衝液(PBS、pH=7.4)中で膨潤させる。次に、このヒドロゲルを機械的に均質化しうる。
Claims (37)
- 架橋ヒアルロン酸の製造法であって、ヒアルロン酸を、ポリエチレングリコール系架橋剤と接触させることを含んで成る方法。
- ポリエチレングリコール系架橋剤が、二官能性である請求項1に記載の方法。
- ポリエチレングリコール系架橋剤が、多官能性である請求項1に記載の方法。
- ヒアルロン酸を、非ポリエチレングリコール系架橋剤と接触させることをさらに含んで成る請求項1に記載の方法。
- ヒアルロン酸を、BDDEと接触させることを含んで成る請求項4に記載の方法。
- ポリエチレングリコール系架橋剤が四官能性であり、ヒアルロン酸をBDDEと接触させることをさらに含んで成る請求項1に記載の方法。
- 請求項1に記載の方法によって得られる軟組織増大用の組成物。
- 請求項6に記載の方法によって得られる軟組織増大用の組成物。
- 架橋ヒアルロン酸の製造法であって、ヒアルロン酸を多官能性架橋剤と接触させることを含んで成る方法。
- 多官能性架橋剤が、四官能性である請求項9に記載の方法。
- 多官能性架橋剤が、4-Arm Star PEGエポキシドである請求項9に記載の方法。
- ヒアルロン酸を、二官能性架橋剤と接触させることをさらに含んで成る請求項11に記載の方法。
- 請求項9に記載の方法によって得られる軟組織増大用の組成物。
- 請求項12に記載の方法によって得られる軟組織増大用の組成物。
- 架橋ヒアルロン酸を、ポリエチレングリコール系ペンダントコーティングでコーティングすることをさらに含んで成る請求項9に記載の方法。
- 請求項15に記載の方法によって得られる軟組織増大用の組成物。
- 軟組織増大用の組成物であって、少なくとも1種類のポリエチレングリコール系架橋剤で架橋されたヒアルロン酸を含んで成る組成物。
- 少なくとも1種類のポリエチレングリコール系架橋剤が、二官能性である請求項17に記載の組成物。
- 少なくとも1種類のポリエチレングリコール系架橋剤が、多官能性である請求項17に記載の組成物。
- 少なくとも1種類のポリエチレングリコール系架橋剤が、4-Arm Star PEGエポキシドである請求項17に記載の組成物。
- ヒアルロン酸が、少なくとも2種類のポリエチレングリコール系架橋剤で架橋され、該少なくとも2種類のポリエチレングリコール系架橋剤の少なくとも1つが多官能性である請求項17に記載の組成物。
- ポリエチレングリコール系ペンダントコーティングをさらに含んで成る請求項17に記載の組成物。
- 皮膚フィラーとして使用される請求項21に記載の組成物。
- 皮膚フィラーとして使用される請求項17に記載の組成物。
- 少なくとも1つの多官能性架橋剤を使用して架橋されたヒアルロン酸を含んで成る皮膚フィラー組成物。
- 少なくとも1つの多官能性架橋剤が、四官能性ポリエチレングルコール系架橋剤である請求項25に記載の皮膚フィラー組成物。
- ヒアルロン酸が、四官能性ポリエチレングルコール系架橋剤および二官能性架橋剤で架橋されている請求項26に記載の皮膚フィラー組成物。
- 二官能性架橋剤が、BDDEである請求項27に記載の皮膚フィラー組成物。
- 患者の軟組織を修復または増大する方法であって、
修復または増大すべき軟組織を選択し、少なくとも1つの多官能性架橋剤を使用して架橋されたヒアルロン酸を含んで成る組成物を、選択された軟組織に注入するステップ
を含んで成る方法。 - 少なくとも1つの多官能性架橋剤が、ポリエチレングリコール系架橋剤である請求項29に記載の方法。
- ヒアルロン酸が、少なくとも1つの多官能性架橋剤および少なくとも1つの二官能性架橋剤を使用して架橋されている請求項29に記載の方法。
- ポリエチレングリコール系ペンダントコーティングでコーティングされたヒアルロン酸を含んで成る軟組織増大用の組成物。
- ヒアルロン酸が、ポリエチレングリコール系架橋剤で架橋されている請求項32に記載の組成物。
- ポリエチレングリコール系架橋剤が、多官能性である請求項33に記載の組成物。
- ヒアルロン酸を架橋する架橋剤であって、ポリエチレングリコール系架橋剤を含んで成る架橋剤。
- 架橋剤が多官能性である請求項35に記載の架橋剤。
- 架橋剤が4-Arm Star PEGエポキシドである請求項35に記載の架橋剤。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US95277007P | 2007-07-30 | 2007-07-30 | |
US60/952,770 | 2007-07-30 | ||
PCT/US2008/070985 WO2009018076A1 (en) | 2007-07-30 | 2008-07-24 | Tunably crosslinked hyaluronic acid compositions |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2014075988A Division JP2014194018A (ja) | 2007-07-30 | 2014-04-02 | 調節可能架橋ヒアルロン酸組成物 |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2010535277A true JP2010535277A (ja) | 2010-11-18 |
JP5518709B2 JP5518709B2 (ja) | 2014-06-11 |
Family
ID=39769477
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2010520076A Expired - Fee Related JP5518709B2 (ja) | 2007-07-30 | 2008-07-24 | 調節可能架橋ヒアルロン酸組成物 |
JP2014075988A Pending JP2014194018A (ja) | 2007-07-30 | 2014-04-02 | 調節可能架橋ヒアルロン酸組成物 |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2014075988A Pending JP2014194018A (ja) | 2007-07-30 | 2014-04-02 | 調節可能架橋ヒアルロン酸組成物 |
Country Status (12)
Country | Link |
---|---|
US (2) | US8318695B2 (ja) |
EP (1) | EP2178923A1 (ja) |
JP (2) | JP5518709B2 (ja) |
KR (1) | KR20100046038A (ja) |
CN (2) | CN101790542B (ja) |
AU (1) | AU2008282541B2 (ja) |
BR (1) | BRPI0815045A2 (ja) |
CA (1) | CA2695179A1 (ja) |
HK (1) | HK1142917A1 (ja) |
MX (1) | MX2010001219A (ja) |
NZ (2) | NZ599888A (ja) |
WO (1) | WO2009018076A1 (ja) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2014515307A (ja) * | 2011-06-03 | 2014-06-30 | アラーガン、インコーポレイテッド | 抗酸化物質を含む皮膚充填剤組成物 |
JP2016515159A (ja) * | 2013-03-15 | 2016-05-26 | レイク リージョン マニュファクチュアリング インコーポレイテッド | 変性ヒアルロネート親水性組成物、コーティングおよび方法 |
US11083684B2 (en) | 2011-06-03 | 2021-08-10 | Allergan Industrie, Sas | Dermal filler compositions |
Families Citing this family (62)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2861734B1 (fr) | 2003-04-10 | 2006-04-14 | Corneal Ind | Reticulation de polysaccharides de faible et forte masse moleculaire; preparation d'hydrogels monophasiques injectables; polysaccharides et hydrogels obtenus |
US20060073208A1 (en) * | 2004-10-01 | 2006-04-06 | Allergan, Inc. | Cosmetic neurotoxin compositions and methods |
CA2687990A1 (en) * | 2007-05-23 | 2008-12-04 | Allergan, Inc. | Cross-linked collagen and uses thereof |
US20110077737A1 (en) * | 2007-07-30 | 2011-03-31 | Allergan, Inc. | Tunably Crosslinked Polysaccharide Compositions |
US20120071437A1 (en) * | 2007-07-30 | 2012-03-22 | Allergan, Inc. | Tunable crosslinked polysaccharide compositions |
US8318695B2 (en) | 2007-07-30 | 2012-11-27 | Allergan, Inc. | Tunably crosslinked polysaccharide compositions |
US8697044B2 (en) | 2007-10-09 | 2014-04-15 | Allergan, Inc. | Crossed-linked hyaluronic acid and collagen and uses thereof |
EP3498299A1 (en) | 2007-11-16 | 2019-06-19 | Aclaris Therapeutics, Inc. | Compositions and methods for treating purpura |
US8394782B2 (en) | 2007-11-30 | 2013-03-12 | Allergan, Inc. | Polysaccharide gel formulation having increased longevity |
US8394784B2 (en) * | 2007-11-30 | 2013-03-12 | Allergan, Inc. | Polysaccharide gel formulation having multi-stage bioactive agent delivery |
US20090143348A1 (en) * | 2007-11-30 | 2009-06-04 | Ahmet Tezel | Polysaccharide gel compositions and methods for sustained delivery of drugs |
US8357795B2 (en) | 2008-08-04 | 2013-01-22 | Allergan, Inc. | Hyaluronic acid-based gels including lidocaine |
EP3184552B1 (en) | 2008-09-02 | 2020-08-12 | Tautona Group LP | Threads of hyaluronic acid, methods of making thereof and uses thereof |
US20100098772A1 (en) * | 2008-10-21 | 2010-04-22 | Allergan, Inc. | Drug delivery systems and methods for treating neovascularization |
JP4885245B2 (ja) * | 2009-01-15 | 2012-02-29 | 日本航空電子工業株式会社 | Rdコンバータ及び角度検出装置 |
KR101551681B1 (ko) | 2009-07-30 | 2015-09-09 | 카르빌란 테라퓨틱스, 인코포레이티드 | 변형된 히알루론산 폴리머 조성물 및 관련방법 |
KR101756493B1 (ko) | 2009-10-29 | 2017-07-10 | 아센디스 파마 에이에스 | 생분해성 하이드로겔의 살균 |
US20110171310A1 (en) * | 2010-01-13 | 2011-07-14 | Allergan Industrie, Sas | Hydrogel compositions comprising vasoconstricting and anti-hemorrhagic agents for dermatological use |
US20110171286A1 (en) * | 2010-01-13 | 2011-07-14 | Allergan, Inc. | Hyaluronic acid compositions for dermatological use |
US20110171311A1 (en) * | 2010-01-13 | 2011-07-14 | Allergan Industrie, Sas | Stable hydrogel compositions including additives |
US20110172180A1 (en) | 2010-01-13 | 2011-07-14 | Allergan Industrie. Sas | Heat stable hyaluronic acid compositions for dermatological use |
US9114188B2 (en) | 2010-01-13 | 2015-08-25 | Allergan, Industrie, S.A.S. | Stable hydrogel compositions including additives |
CA2792729C (en) | 2010-03-12 | 2016-06-28 | Allergan Industrie, Sas | Fluid compositions for improving skin conditions |
CA2794254C (en) | 2010-03-22 | 2018-09-04 | Allergan, Inc. | Polysaccharide and protein-polysaccharide cross-linked hydrogels for soft tissue augmentation |
US8697057B2 (en) | 2010-08-19 | 2014-04-15 | Allergan, Inc. | Compositions and soft tissue replacement methods |
US9005605B2 (en) | 2010-08-19 | 2015-04-14 | Allergan, Inc. | Compositions and soft tissue replacement methods |
US8889123B2 (en) | 2010-08-19 | 2014-11-18 | Allergan, Inc. | Compositions and soft tissue replacement methods |
US8883139B2 (en) | 2010-08-19 | 2014-11-11 | Allergan Inc. | Compositions and soft tissue replacement methods |
US9408797B2 (en) | 2011-06-03 | 2016-08-09 | Allergan, Inc. | Dermal filler compositions for fine line treatment |
US9393263B2 (en) | 2011-06-03 | 2016-07-19 | Allergan, Inc. | Dermal filler compositions including antioxidants |
CN102226009B (zh) * | 2011-06-09 | 2013-04-10 | 西安力邦制药有限公司 | 一种交联透明质酸凝胶的制备方法 |
US9662422B2 (en) | 2011-09-06 | 2017-05-30 | Allergan, Inc. | Crosslinked hyaluronic acid-collagen gels for improving tissue graft viability and soft tissue augmentation |
US20130244943A1 (en) | 2011-09-06 | 2013-09-19 | Allergan, Inc. | Hyaluronic acid-collagen matrices for dermal filling and volumizing applications |
TWI561535B (en) * | 2011-10-06 | 2016-12-11 | Bvw Holding Ag | Copolymers of hydrophobic and hydrophilic segments that reduce protein adsorption |
JP6174690B2 (ja) | 2012-06-15 | 2017-08-02 | メルツ ファーマ ゲゼルシャフト ミット ベシュレンクテル ハフツング ウント コンパニー コマンディト ゲゼルシャフト アウフ アクティーン | ヒアルロン酸に基づく組成物の調製方法 |
CN102784414B (zh) * | 2012-08-02 | 2014-07-23 | 东华大学 | 一种可用于组织工程的可注射性双交联水凝胶的制备方法 |
WO2014055895A1 (en) * | 2012-10-05 | 2014-04-10 | Allergan, Inc. | Injectable device and method for sculpting, augmenting or correcting facial features such as the chin |
BR112015017040B1 (pt) * | 2013-01-17 | 2020-11-03 | Jeffrey Hagel | uso de ácido hialurônico para aumentar volume muscular de músculo e alterar contorno de músculo em um ser humano |
US20140315828A1 (en) | 2013-04-22 | 2014-10-23 | Allergan, Inc. | Cross-linked silk-hyaluronic acid compositions |
JP6056111B2 (ja) | 2013-05-22 | 2017-01-11 | 国立研究開発法人産業技術総合研究所 | 光分解性架橋剤、光分解性ゲル、細胞培養器具、細胞配列・分別装置、細胞配列方法、細胞分別方法、組織体形成方法および組織体 |
EP3013865B1 (en) * | 2013-06-28 | 2019-10-23 | Galderma S.A. | Method for manufacturing a shaped cross-linked hyaluronic acid product |
CN103920182B (zh) * | 2014-04-16 | 2015-10-21 | 华熙福瑞达生物医药有限公司 | 一种生物可吸收止血膜 |
CN103923229B (zh) * | 2014-04-30 | 2016-02-03 | 苏州金诺生物技术有限公司 | 一种交联透明质酸钠及其制备方法 |
WO2016051219A1 (en) | 2014-09-30 | 2016-04-07 | Allergan Industrie, Sas | Stable hydrogel compositions including additives |
WO2016128783A1 (en) | 2015-02-09 | 2016-08-18 | Allergan Industrie Sas | Compositions and methods for improving skin appearance |
WO2017001057A1 (en) | 2015-06-30 | 2017-01-05 | Merz Pharma Gmbh & Co. Kgaa | Method of preparing a composition based on hyaluronic acid |
KR20170090965A (ko) * | 2016-01-29 | 2017-08-08 | 한미약품 주식회사 | 복합 히알루론산 가교물 및 그 제조방법 |
EP3503841A4 (en) | 2016-08-24 | 2020-04-22 | Allergan, Inc. | CO-CROSSLINKED HYALURONIC ACID-FIBROIN HYDROGELS FOR IMPROVING THE SUSTAINABILITY OF TISSUE GRAFTS AND FOR INCREASING SOFT TISSUES |
CN106589424B (zh) * | 2016-12-12 | 2020-06-02 | 华熙生物科技股份有限公司 | 一种注射用交联透明质酸凝胶及其制备方法 |
AR111190A1 (es) | 2017-03-22 | 2019-06-12 | Genentech Inc | Composiciones en hidrogel de prodrogas entrecruzadas de ácido hialurónico y métodos relacionados |
US20230190997A1 (en) | 2017-06-26 | 2023-06-22 | Evolved By Nature, Inc. | Silk-hyaluronic acid based tissue filers and methods of using the same |
CN109096483B (zh) * | 2017-06-28 | 2020-09-04 | 北京键凯科技股份有限公司 | 分枝型多元甘醇环氧衍生物交联透明质酸钠凝胶及其制备和应用 |
CN107936272B (zh) * | 2017-11-27 | 2020-11-10 | 华熙生物科技股份有限公司 | 一种用于放疗防护的3d交联透明质酸盐凝胶的制备方法及其产品 |
CN107955194A (zh) * | 2017-11-29 | 2018-04-24 | 桂林华诺威生物科技有限公司 | 高质量交联透明质酸钠凝胶的制备方法 |
CN111918640A (zh) | 2017-12-29 | 2020-11-10 | 马特克斯拉比有限公司 | 具有透明质酸基的填充物的制备方法 |
KR102524417B1 (ko) * | 2017-12-29 | 2023-04-24 | 마텍스 랩 에스.피.에이 | 특정한 가교제를 사용하여 히알루론산 염기를 가지는 필러를 제조하는 방법 |
US20210402064A1 (en) | 2018-05-09 | 2021-12-30 | The Johns Hopkins University | Nanofiber-hydrogel composites for enhanced soft tissue replacement and regeneration |
CN112384258A (zh) | 2018-05-09 | 2021-02-19 | 约翰·霍普金斯大学 | 用于细胞和组织递送的纳米纤维-水凝胶复合物 |
CN108774329A (zh) * | 2018-06-13 | 2018-11-09 | 浙江景嘉医疗科技有限公司 | 一种医用交联透明质酸钠凝胶的制备方法 |
CN113677320A (zh) * | 2018-12-19 | 2021-11-19 | 自然进化公司 | 丝-透明质酸组织填充物及其制备和使用方法 |
CN112480483B (zh) * | 2020-11-27 | 2022-02-01 | 华熙生物科技股份有限公司 | 一种依克多因-透明质酸复合凝胶的制备方法及所得产品 |
TW202333793A (zh) | 2022-01-11 | 2023-09-01 | 義大利商Gpq有限公司 | 作為創新填充劑之新玻尿酸衍生物 |
Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS61234864A (ja) * | 1985-03-01 | 1986-10-20 | バイオマトリクス・インコーポレイテツド | 架橋ヒアルロン酸の成形物 |
JPH0853548A (ja) * | 1994-05-02 | 1996-02-27 | Collagn Corp | 多段階反応を用いて調製されるコラーゲン−合成ポリマーマトリックス |
JP2003055401A (ja) * | 2001-08-21 | 2003-02-26 | Japan Science & Technology Corp | 多官能性架橋剤によって架橋したグリコサミノグリカン−ポリカチオン複合体とその製造法 |
WO2004022603A1 (en) * | 2002-09-03 | 2004-03-18 | Lg Life Sciences Ltd. | Hyaluronic acid derivatives and processes for preparing the same |
US20040127698A1 (en) * | 2002-12-31 | 2004-07-01 | Industrial Technology Research Institute | Method for producing double-crosslinked hyaluronate material |
JP2006523731A (ja) * | 2003-04-17 | 2006-10-19 | ウルトラシューティカルズ アールアンドディー ピーティーワイ リミテッド | 架橋多糖類組成物 |
Family Cites Families (130)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2128827A (en) | 1938-03-09 | 1938-08-30 | Frank B Killian | Method and apparatus for manufacturing thin rubber articles |
JPS4838158B1 (ja) | 1970-10-05 | 1973-11-15 | ||
CA949965A (en) | 1971-12-03 | 1974-06-25 | Robert H. Marchessault | Method of preparing cross-linked starch and starch derivatives |
JPS6050128A (ja) * | 1983-08-25 | 1985-03-19 | Daihachi Kagaku Kogyosho:Kk | 水溶液からの鉄(3)の抽出方法および抽出溶媒からの鉄(3)の逆抽出方法 |
SE442820B (sv) | 1984-06-08 | 1986-02-03 | Pharmacia Ab | Gel av tverbunden hyaluronsyra for anvendning som glaskroppssubstitut |
SE456346B (sv) | 1984-07-23 | 1988-09-26 | Pharmacia Ab | Gel for att forhindra adhesion mellan kroppsvevnader och sett for dess framstellning |
US4636524A (en) | 1984-12-06 | 1987-01-13 | Biomatrix, Inc. | Cross-linked gels of hyaluronic acid and products containing such gels |
US4582865A (en) | 1984-12-06 | 1986-04-15 | Biomatrix, Inc. | Cross-linked gels of hyaluronic acid and products containing such gels |
US4605691A (en) | 1984-12-06 | 1986-08-12 | Biomatrix, Inc. | Cross-linked gels of hyaluronic acid and products containing such gels |
US4713448A (en) | 1985-03-12 | 1987-12-15 | Biomatrix, Inc. | Chemically modified hyaluronic acid preparation and method of recovery thereof from animal tissues |
FR2608456B1 (fr) | 1986-12-18 | 1993-06-18 | Mero Rousselot Satia | Microcapsules a base de gelatine et de polysaccharides et leur procede d'obtention |
US5091171B2 (en) | 1986-12-23 | 1997-07-15 | Tristrata Inc | Amphoteric compositions and polymeric forms of alpha hydroxyacids and their therapeutic use |
US5385938B1 (en) | 1986-12-23 | 1997-07-15 | Tristrata Inc | Method of using glycolic acid for treating wrinkles |
FR2623167B2 (fr) | 1987-08-14 | 1992-08-07 | Genus Int | Perfectionnement aux articles munis d'articulations elastiques se rigidifiant lors de leur mise en tension |
US5643464A (en) | 1988-11-21 | 1997-07-01 | Collagen Corporation | Process for preparing a sterile, dry crosslinking agent |
SE462587B (sv) | 1988-11-30 | 1990-07-23 | Wiklund Henry & Co | Anordning vid maerkning av arbetsstycken med skrift- eller andra tecken |
JPH02215707A (ja) | 1989-02-15 | 1990-08-28 | Chisso Corp | 皮膚化粧料 |
DE69019779T2 (de) | 1989-05-19 | 1995-12-14 | Hayashibara Biochem Lab | Alpha-Glycosyl-L-ascorbinsäure und ihre Herstellung und Verwendungen. |
EP0416250A3 (en) | 1989-08-01 | 1991-08-28 | The Research Foundation Of State University Of New York | N-acylurea and o-acylisourea derivatives of hyaluronic acid |
US5356883A (en) | 1989-08-01 | 1994-10-18 | Research Foundation Of State University Of N.Y. | Water-insoluble derivatives of hyaluronic acid and their methods of preparation and use |
CA2023922A1 (en) | 1989-09-05 | 1991-03-06 | James M. Curtis | Method of manufacturing an implantable article provided with a micropillared surface |
JP2832848B2 (ja) | 1989-10-21 | 1998-12-09 | 株式会社林原生物化学研究所 | 結晶2―O―α―D―グルコピラノシル―L―アスコルビン酸とその製造方法並びに用途 |
US5143724A (en) | 1990-07-09 | 1992-09-01 | Biomatrix, Inc. | Biocompatible viscoelastic gel slurries, their preparation and use |
US5246698A (en) | 1990-07-09 | 1993-09-21 | Biomatrix, Inc. | Biocompatible viscoelastic gel slurries, their preparation and use |
JP3115625B2 (ja) | 1991-03-30 | 2000-12-11 | 帝國製薬株式会社 | リドカイン含有外用貼付剤 |
US5314874A (en) | 1991-04-19 | 1994-05-24 | Koken Co., Ltd. | Intracorporeally injectable composition for implanting highly concentrated cross-linked atelocollagen |
JP3366994B2 (ja) | 1993-01-20 | 2003-01-14 | イー アール スクイブ アンド サンズ インコーポレーテッド | ファイバー |
WO1994021299A1 (en) | 1993-03-19 | 1994-09-29 | Medinvent | A composition and a method for tissue augmentation |
US5531716A (en) | 1993-09-29 | 1996-07-02 | Hercules Incorporated | Medical devices subject to triggered disintegration |
US5616568A (en) | 1993-11-30 | 1997-04-01 | The Research Foundation Of State University Of New York | Functionalized derivatives of hyaluronic acid |
AU706434B2 (en) | 1994-10-18 | 1999-06-17 | Ethicon Inc. | Injectable liquid copolymers for soft tissue repair and augmentation |
FR2733427B1 (fr) | 1995-04-25 | 2001-05-25 | W K Et Associes | Compositions biphasiques injectables renfermant de l'acide hyaluronique, notamment utiles en chirurgies reparatrice et esthetique |
US6214331B1 (en) | 1995-06-06 | 2001-04-10 | C. R. Bard, Inc. | Process for the preparation of aqueous dispersions of particles of water-soluble polymers and the particles obtained |
US5571503A (en) | 1995-08-01 | 1996-11-05 | Mausner; Jack | Anti-pollution cosmetic composition |
US6063405A (en) | 1995-09-29 | 2000-05-16 | L.A.M. Pharmaceuticals, Llc | Sustained release delivery system |
IT1277707B1 (it) | 1995-12-22 | 1997-11-11 | Chemedica Sa | Formulazione oftalmica a base di ialuronato di sodio per uso nella chirurgia oculare |
US5980948A (en) | 1996-08-16 | 1999-11-09 | Osteotech, Inc. | Polyetherester copolymers as drug delivery matrices |
US6066325A (en) | 1996-08-27 | 2000-05-23 | Fusion Medical Technologies, Inc. | Fragmented polymeric compositions and methods for their use |
IT1287967B1 (it) | 1996-10-17 | 1998-09-10 | Fidia Spa In Amministrazione S | Preparazioni farmaceutiche per uso anestetico locale |
FR2759576B1 (fr) | 1997-02-17 | 1999-08-06 | Corneal Ind | Implant de sclero-keratectomie pre-descemetique |
FR2759577B1 (fr) | 1997-02-17 | 1999-08-06 | Corneal Ind | Implant de sclerectomie profonde |
US5935164A (en) | 1997-02-25 | 1999-08-10 | Pmt Corporaton | Laminated prosthesis and method of manufacture |
FR2764514B1 (fr) | 1997-06-13 | 1999-09-03 | Biopharmex Holding Sa | Implant injectable en sous-cutane ou intradermique a bioresorbabilite controlee pour la chirurgie reparatrice ou plastique et la dermatologie esthetique |
US7192984B2 (en) | 1997-06-17 | 2007-03-20 | Fziomed, Inc. | Compositions of polyacids and polyethers and methods for their use as dermal fillers |
US6391336B1 (en) | 1997-09-22 | 2002-05-21 | Royer Biomedical, Inc. | Inorganic-polymer complexes for the controlled release of compounds including medicinals |
FR2780730B1 (fr) | 1998-07-01 | 2000-10-13 | Corneal Ind | Compositions biphasiques injectables, notamment utiles en chirurgies reparatrice et esthetique |
DK172900B1 (da) | 1998-12-18 | 1999-09-27 | Per Julius Nielsen | Præparat samt kit til brug ved intraoculære operationer |
GB9902412D0 (en) * | 1999-02-03 | 1999-03-24 | Fermentech Med Ltd | Process |
GB9902652D0 (en) | 1999-02-05 | 1999-03-31 | Fermentech Med Ltd | Process |
US6767928B1 (en) | 1999-03-19 | 2004-07-27 | The Regents Of The University Of Michigan | Mineralization and biological modification of biomaterial surfaces |
US6372494B1 (en) | 1999-05-14 | 2002-04-16 | Advanced Tissue Sciences, Inc. | Methods of making conditioned cell culture medium compositions |
US6521223B1 (en) | 2000-02-14 | 2003-02-18 | Genzyme Corporation | Single phase gels for the prevention of adhesions |
KR20010096388A (ko) | 2000-04-19 | 2001-11-07 | 진세훈 | 귀두확대성형재료 및 이 재료를 이용한 귀두의 확대시술방법 |
FR2811996B1 (fr) | 2000-07-19 | 2003-08-08 | Corneal Ind | Reticulation de polysaccharide(s), preparation d'hydrogel(s) ; polysaccharide(s) et hydrogel(s) obtenus,leurs utilisations |
US6620196B1 (en) | 2000-08-30 | 2003-09-16 | Sdgi Holdings, Inc. | Intervertebral disc nucleus implants and methods |
US6773723B1 (en) | 2000-08-30 | 2004-08-10 | Depuy Acromed, Inc. | Collagen/polysaccharide bilayer matrix |
US6924273B2 (en) | 2000-10-03 | 2005-08-02 | Scott W. Pierce | Chondroprotective/restorative compositions and methods of use thereof |
AU2001294459A1 (en) | 2000-10-06 | 2002-04-15 | Jagotec Ag | A controlled-release, parenterally administrable microparticle preparation |
WO2003053325A2 (en) | 2000-12-13 | 2003-07-03 | Purdue Research Foundation | Microencapsulation of drugs by solvent exchange |
US6979440B2 (en) | 2001-01-29 | 2005-12-27 | Salvona, Llc | Compositions and method for targeted controlled delivery of active ingredients and sensory markers onto hair, skin, and fabric |
US7119062B1 (en) | 2001-02-23 | 2006-10-10 | Neucoll, Inc. | Methods and compositions for improved articular surgery using collagen |
TW574301B (en) * | 2001-05-02 | 2004-02-01 | Ind Tech Res Inst | Manufacturing method of epoxide crosslinked polysaccharides matrix |
JP4490095B2 (ja) | 2001-06-29 | 2010-06-23 | メドグラフト マイクロテック インコーポレイテッド | 生体分解性の注入可能な移植物およびそれに関連する製造方法ならびに使用方法 |
US6749841B2 (en) | 2001-07-26 | 2004-06-15 | Revlon Consumer Products Corporation | Stabilized aqueous acidic antiperspirant compositions and related methods |
US6780366B2 (en) | 2002-08-15 | 2004-08-24 | Mentor Corporation | Drip retainer |
US20040127932A1 (en) | 2002-09-12 | 2004-07-01 | Shah Tilak M. | Dip-molded polymeric medical devices with reverse thickness gradient, and method of making same |
DE10246340A1 (de) | 2002-10-04 | 2004-04-29 | Wohlrab, David, Dr. | Kombinationspräparat aus Hyaluronsäure und mindestens einem Lokalanästhetikum und dessen Verwendung |
US20040101959A1 (en) | 2002-11-21 | 2004-05-27 | Olga Marko | Treatment of tissue with undifferentiated mesenchymal cells |
EP1581270A2 (en) | 2002-12-30 | 2005-10-05 | Angiotech International Ag | Silk-containing stent graft |
FR2861734B1 (fr) | 2003-04-10 | 2006-04-14 | Corneal Ind | Reticulation de polysaccharides de faible et forte masse moleculaire; preparation d'hydrogels monophasiques injectables; polysaccharides et hydrogels obtenus |
JP2004323453A (ja) | 2003-04-25 | 2004-11-18 | Chisso Corp | 分解性ゲル及びその製造法 |
CN100352031C (zh) | 2003-05-13 | 2007-11-28 | 三益半导体工业株式会社 | 晶片分离方法、晶片分离装置及晶片分离转移机 |
CA2534033A1 (fr) | 2003-07-30 | 2005-02-10 | Anteis S.A. | Matrice complexe a usage biomedical |
ES2406555T3 (es) | 2003-10-29 | 2013-06-07 | Teijin Limited | Compuesto de ácido hialurónico, hidrogel del mismo y material para tratar articulaciones |
US20090148527A1 (en) | 2007-12-07 | 2009-06-11 | Robinson Michael R | Intraocular formulation |
US20070224278A1 (en) | 2003-11-12 | 2007-09-27 | Lyons Robert T | Low immunogenicity corticosteroid compositions |
US20060141049A1 (en) | 2003-11-12 | 2006-06-29 | Allergan, Inc. | Triamcinolone compositions for intravitreal administration to treat ocular conditions |
US20050101582A1 (en) | 2003-11-12 | 2005-05-12 | Allergan, Inc. | Compositions and methods for treating a posterior segment of an eye |
WO2005051451A2 (en) | 2003-11-20 | 2005-06-09 | Angiotech International Ag | Electrical devices and anti-scarring agents |
US8124120B2 (en) | 2003-12-22 | 2012-02-28 | Anika Therapeutics, Inc. | Crosslinked hyaluronic acid compositions for tissue augmentation |
WO2005066215A1 (en) | 2003-12-30 | 2005-07-21 | Genzyme Corporation | Cohesive gels form cross-linked hyaluronan and/or hylan, their preparation and use |
DE102004002001A1 (de) | 2004-01-14 | 2005-08-11 | Reinmüller, Johannes, Dr.med. | Mittel zur Behandlung von entzündlichen Erkrankungen |
CA2536096A1 (en) | 2004-01-30 | 2005-08-18 | Angiotech International Ag | Compositions and methods for treating contracture |
US20050226936A1 (en) | 2004-04-08 | 2005-10-13 | Q-Med Ab | Method of soft tissue augmentation |
US8288362B2 (en) | 2004-05-07 | 2012-10-16 | S.K. Pharmaceuticals, Inc. | Stabilized glycosaminoglycan preparations and related methods |
ES2609105T3 (es) | 2004-05-20 | 2017-04-18 | Mentor Worldwide Llc | Método de enlance covalente de ácido hialurónico y quitosano |
CN101027065A (zh) | 2004-06-15 | 2007-08-29 | 陈献 | 磷脂组合物及其制备和使用方法 |
AU2005258231A1 (en) * | 2004-06-23 | 2006-01-05 | Angiotech Pharmaceuticals (Us), Inc. | Methods and crosslinked polymer compositions for cartilage repair |
JP2008509935A (ja) | 2004-08-13 | 2008-04-03 | アンジオテック インターナショナル アーゲー | ヒアルロン酸およびヒアルロン酸インヒビターを用いる組成物および方法 |
US7414021B2 (en) | 2004-10-01 | 2008-08-19 | Vincent Carmine Giampapa | Method and composition for restoration of age related tissue loss in the face or selected areas of the body |
KR100762928B1 (ko) | 2004-10-29 | 2007-10-04 | 재단법인서울대학교산학협력재단 | 견 피브로인 나노섬유로 이루어진 부직포 형태의 골조직유도 재생용 차폐막 및 그 제조방법 |
FR2878444B1 (fr) | 2004-11-30 | 2008-04-25 | Corneal Ind Soc Par Actions Si | Solutions viscoelastiques renfermant du hyaluronate de sodiu et de l'hydroxypropylmethylcellulose, preparation et utilisations |
US20060257488A1 (en) | 2005-05-10 | 2006-11-16 | Cytophil, Inc. | Injectable hydrogels and methods of making and using same |
EP1726299A3 (en) | 2005-05-27 | 2007-04-18 | StratoSphere Pharma AB | Cores and microcapsules suitable for parenteral administration as well as process for their manufacture |
CN102266274B (zh) | 2005-08-11 | 2016-05-18 | 株式会社林原 | 胶原产生增强剂及其用途 |
JP4982718B2 (ja) | 2005-08-31 | 2012-07-25 | 株式会社林原 | 美肌用の経口摂取用組成物 |
EP3015101B1 (en) | 2005-10-03 | 2019-08-21 | PINSKY, Mark A. | Non-phospholipid liposomes comprising hyaluronic acid |
US20070203095A1 (en) | 2005-12-14 | 2007-08-30 | Anika Therapeutics, Inc. | Treatment of arthritis and other musculoskeletal disorders with crosslinked hyaluronic acid |
FR2894827B1 (fr) | 2005-12-21 | 2010-10-29 | Galderma Res & Dev | Preparations pharmaceutiques ou cosmetiques pour application topique et/ou parenterale, leurs procedes de preparation,et leurs utilisations |
US20070184087A1 (en) | 2006-02-06 | 2007-08-09 | Bioform Medical, Inc. | Polysaccharide compositions for use in tissue augmentation |
US20070212385A1 (en) | 2006-03-13 | 2007-09-13 | David Nathaniel E | Fluidic Tissue Augmentation Compositions and Methods |
CA2645324A1 (en) | 2006-03-15 | 2007-09-27 | Surmodics, Inc. | Hydrophobic derivatives of natural biodegradable polysaccharides and uses thereof |
US20070298005A1 (en) | 2006-06-22 | 2007-12-27 | Marie-Josee Thibault | Injectable composition for treatment of skin defects or deformations |
US20100035838A1 (en) | 2006-09-19 | 2010-02-11 | Geoffrey Kenneth Heber | Cross-linked polysaccharide gels |
FR2908415B1 (fr) | 2006-11-10 | 2009-01-23 | Abr Dev Sarl | Acide hyaluronique reticule et son procede de preparation |
KR100759091B1 (ko) | 2006-12-13 | 2007-09-17 | 조강선 | 피부 충전제 조성물 |
US20080188416A1 (en) | 2007-02-05 | 2008-08-07 | Freedom-2, Inc. | Tissue fillers and methods of using the same |
US7776840B2 (en) | 2007-02-21 | 2010-08-17 | Cutanea Life Sciences, Inc. | Methods of use of biomaterial and injectable implant containing biomaterial |
US7939578B2 (en) | 2007-02-23 | 2011-05-10 | 3M Innovative Properties Company | Polymeric fibers and methods of making |
US8642067B2 (en) | 2007-04-02 | 2014-02-04 | Allergen, Inc. | Methods and compositions for intraocular administration to treat ocular conditions |
US11078262B2 (en) | 2007-04-30 | 2021-08-03 | Allergan, Inc. | High viscosity macromolecular compositions for treating ocular conditions |
CA2687990A1 (en) | 2007-05-23 | 2008-12-04 | Allergan, Inc. | Cross-linked collagen and uses thereof |
AU2008256864A1 (en) | 2007-05-23 | 2008-12-04 | Allergan, Inc. | Coated hyaluronic acid particles |
EP2520309A1 (en) | 2007-07-27 | 2012-11-07 | Humacyte, Inc. | Compositions and methods for soft tissue augmentation |
US8318695B2 (en) | 2007-07-30 | 2012-11-27 | Allergan, Inc. | Tunably crosslinked polysaccharide compositions |
FR2920000B1 (fr) | 2007-08-13 | 2010-01-29 | Oreal | Composition cosmetique ou pharmaceutique contenant de l'acide hyaluronique, et procede cosmetique pour diminuer les signes du vieilissement |
US8697044B2 (en) | 2007-10-09 | 2014-04-15 | Allergan, Inc. | Crossed-linked hyaluronic acid and collagen and uses thereof |
US7910134B2 (en) | 2007-10-29 | 2011-03-22 | Ayman Boutros | Alloplastic injectable dermal filler and methods of use thereof |
US20090143348A1 (en) | 2007-11-30 | 2009-06-04 | Ahmet Tezel | Polysaccharide gel compositions and methods for sustained delivery of drugs |
US8394784B2 (en) | 2007-11-30 | 2013-03-12 | Allergan, Inc. | Polysaccharide gel formulation having multi-stage bioactive agent delivery |
US8394782B2 (en) | 2007-11-30 | 2013-03-12 | Allergan, Inc. | Polysaccharide gel formulation having increased longevity |
FR2924615B1 (fr) | 2007-12-07 | 2010-01-22 | Vivacy Lab | Hydrogel cohesif biodegradable. |
US9161970B2 (en) | 2007-12-12 | 2015-10-20 | Allergan, Inc. | Dermal filler |
US20090169615A1 (en) | 2007-12-26 | 2009-07-02 | Pinsky Mark A | Collagen Formulations for Improved Skin Care |
US20090291986A1 (en) | 2008-05-22 | 2009-11-26 | Apostolos Pappas | Composition and method of treating facial skin defect |
US20090297632A1 (en) | 2008-06-02 | 2009-12-03 | Waugh Jacob M | Device, Methods and Compositions to Alter Light Interplay with Skin |
US8357795B2 (en) | 2008-08-04 | 2013-01-22 | Allergan, Inc. | Hyaluronic acid-based gels including lidocaine |
US20100111919A1 (en) | 2008-10-31 | 2010-05-06 | Tyco Healthcare Group Lp | Delayed gelation compositions and methods of use |
WO2010065784A2 (en) | 2008-12-03 | 2010-06-10 | Jakk Group, Inc. | Methods, devices, and compositions for dermal filling |
PL2236523T3 (pl) | 2009-03-30 | 2018-07-31 | Scivision Biotech Inc. | Sposób wytwarzania usieciowanego kwasu hialuronowego |
-
2008
- 2008-07-23 US US12/178,574 patent/US8318695B2/en not_active Expired - Fee Related
- 2008-07-24 CN CN200880104839.2A patent/CN101790542B/zh not_active Expired - Fee Related
- 2008-07-24 CA CA2695179A patent/CA2695179A1/en not_active Abandoned
- 2008-07-24 BR BRPI0815045-1A2A patent/BRPI0815045A2/pt not_active IP Right Cessation
- 2008-07-24 MX MX2010001219A patent/MX2010001219A/es not_active Application Discontinuation
- 2008-07-24 NZ NZ599888A patent/NZ599888A/xx not_active IP Right Cessation
- 2008-07-24 NZ NZ583031A patent/NZ583031A/en not_active IP Right Cessation
- 2008-07-24 AU AU2008282541A patent/AU2008282541B2/en not_active Ceased
- 2008-07-24 EP EP08782305A patent/EP2178923A1/en not_active Withdrawn
- 2008-07-24 KR KR1020107004192A patent/KR20100046038A/ko not_active Application Discontinuation
- 2008-07-24 CN CN2012103527224A patent/CN102850468A/zh active Pending
- 2008-07-24 JP JP2010520076A patent/JP5518709B2/ja not_active Expired - Fee Related
- 2008-07-24 WO PCT/US2008/070985 patent/WO2009018076A1/en active Application Filing
-
2010
- 2010-09-27 HK HK10109227.4A patent/HK1142917A1/xx not_active IP Right Cessation
-
2012
- 2012-09-21 US US13/624,700 patent/US20130023658A1/en not_active Abandoned
-
2014
- 2014-04-02 JP JP2014075988A patent/JP2014194018A/ja active Pending
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS61234864A (ja) * | 1985-03-01 | 1986-10-20 | バイオマトリクス・インコーポレイテツド | 架橋ヒアルロン酸の成形物 |
JPH0853548A (ja) * | 1994-05-02 | 1996-02-27 | Collagn Corp | 多段階反応を用いて調製されるコラーゲン−合成ポリマーマトリックス |
JP2003055401A (ja) * | 2001-08-21 | 2003-02-26 | Japan Science & Technology Corp | 多官能性架橋剤によって架橋したグリコサミノグリカン−ポリカチオン複合体とその製造法 |
WO2004022603A1 (en) * | 2002-09-03 | 2004-03-18 | Lg Life Sciences Ltd. | Hyaluronic acid derivatives and processes for preparing the same |
US20040127698A1 (en) * | 2002-12-31 | 2004-07-01 | Industrial Technology Research Institute | Method for producing double-crosslinked hyaluronate material |
JP2006523731A (ja) * | 2003-04-17 | 2006-10-19 | ウルトラシューティカルズ アールアンドディー ピーティーワイ リミテッド | 架橋多糖類組成物 |
Cited By (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2014515307A (ja) * | 2011-06-03 | 2014-06-30 | アラーガン、インコーポレイテッド | 抗酸化物質を含む皮膚充填剤組成物 |
JP2017008097A (ja) * | 2011-06-03 | 2017-01-12 | アラーガン、インコーポレイテッドAllergan,Incorporated | 抗酸化物質を含む皮膚充填剤組成物 |
JP2017217500A (ja) * | 2011-06-03 | 2017-12-14 | アラーガン、インコーポレイテッドAllergan,Incorporated | 抗酸化物質を含む皮膚充填剤組成物 |
JP2020179280A (ja) * | 2011-06-03 | 2020-11-05 | アラーガン・アンデュストリー・ソシエテ・パール・アクシオン・サンプリフィエAllergan Industrie Sas | 抗酸化物質を含む皮膚充填剤組成物 |
US11083684B2 (en) | 2011-06-03 | 2021-08-10 | Allergan Industrie, Sas | Dermal filler compositions |
JP6995946B2 (ja) | 2011-06-03 | 2022-01-17 | アラーガン・アンデュストリー・ソシエテ・パール・アクシオン・サンプリフィエ | 抗酸化物質を含む皮膚充填剤組成物 |
JP2016515159A (ja) * | 2013-03-15 | 2016-05-26 | レイク リージョン マニュファクチュアリング インコーポレイテッド | 変性ヒアルロネート親水性組成物、コーティングおよび方法 |
Also Published As
Publication number | Publication date |
---|---|
NZ583031A (en) | 2012-05-25 |
CN102850468A (zh) | 2013-01-02 |
US8318695B2 (en) | 2012-11-27 |
JP5518709B2 (ja) | 2014-06-11 |
JP2014194018A (ja) | 2014-10-09 |
AU2008282541A1 (en) | 2009-02-05 |
AU2008282541B2 (en) | 2013-09-26 |
WO2009018076A1 (en) | 2009-02-05 |
BRPI0815045A2 (pt) | 2015-02-10 |
CA2695179A1 (en) | 2009-02-05 |
EP2178923A1 (en) | 2010-04-28 |
US20090036403A1 (en) | 2009-02-05 |
US20130023658A1 (en) | 2013-01-24 |
NZ599888A (en) | 2013-08-30 |
CN101790542B (zh) | 2014-03-12 |
HK1142917A1 (en) | 2010-12-17 |
MX2010001219A (es) | 2010-03-01 |
KR20100046038A (ko) | 2010-05-04 |
CN101790542A (zh) | 2010-07-28 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JP5518709B2 (ja) | 調節可能架橋ヒアルロン酸組成物 | |
Li et al. | Self-healing hyaluronic acid hydrogels based on dynamic Schiff base linkages as biomaterials | |
Pandit et al. | Periodate oxidized hyaluronic acid-based hydrogel scaffolds for tissue engineering applications | |
AU773628B2 (en) | Process for cross-linking hyaluronic acid to polymers | |
CA2361981C (en) | Process for the production of multiple cross-linked hyaluronic acid derivatives | |
AU757102B2 (en) | Cross-linked hyaluronic acids and medical uses thereof | |
Saraiva et al. | Synthesis and characterization of a photocrosslinkable chitosan–gelatin hydrogel aimed for tissue regeneration | |
CN111194218B (zh) | 生物可相容材料以及用于制备和使用所述生物可相容材料的方法 | |
Sato et al. | Catechol-modified hyaluronic acid: in situ-forming hydrogels by auto-oxidation of catechol or photo-oxidation using visible light | |
CN112535766A (zh) | 基于人间充质干细胞细胞外基质来源复合胶原蛋白提取液水凝胶及其制备方法 | |
AU2013273820A1 (en) | Tunably crosslinked hyaluronic acid compositions | |
JP2023081477A (ja) | 多糖誘導体、多糖誘導体を含む架橋構造体、架橋構造体の製造方法 | |
WO2024016079A1 (en) | Methods for transforming polysaccharides to cross-linkable polysaccharides and products thereof |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20110721 |
|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20130514 |
|
A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20130813 |
|
A602 | Written permission of extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A602 Effective date: 20130820 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20130912 |
|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20131008 |
|
A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20140107 |
|
A602 | Written permission of extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A602 Effective date: 20140115 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20140206 |
|
TRDD | Decision of grant or rejection written | ||
A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20140304 |
|
A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20140402 |
|
R150 | Certificate of patent or registration of utility model |
Ref document number: 5518709 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
LAPS | Cancellation because of no payment of annual fees |